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- | cisplatin / Generic mfg.
Journal: Cisplatin-Resistant Gastric Cancer Cells Promote the Chemoresistance of Cisplatin-Sensitive Cells via the Exosomal RPS3-Mediated PI3K-Akt-Cofilin-1 Signaling Axis. (Pubmed Central) - Mar 2, 2021
All these findings demonstrated that cisplatin-resistant gastric cancer cells communicate with sensitive cells through the intercellular delivery of exosomal RPS3 and activation of the PI3K-Akt-cofilin-1 signaling pathway. Targeting exosomal RPS3 protein in cisplatin-resistant gastric cancer cells may thus be a promising strategy to overcome cisplatin resistance in gastric cancer.
- | icaritin (SNG-162) / Shenogen Pharma
Journal: Effect of icaritin on proliferation and apoptosis of human ovarian cancer cells SKOV3 (Pubmed Central) - Mar 2, 2021
The protein expression of PI3K and p-Akt in icaritin groups were reduced(P<0.05). These results indicated that icarin may inhibit the proliferation of ovarian cancer SKOV3 cells in vitro, induce cell apoptosis and affect the cycle distribution of cells by inhibiting the PI3K/Akt signaling pathway.
- || The usual on a Sunday: a list of relevant articles for understanding #PI3K signalling in #development and #cancer. Also, as usual - thanks to @BiomedNew ! - https://t.co/KNPZeldj75 (Twitter) - Feb 28, 2021
- | Journal: Swimming exercise stimulates IGF1/ PI3K/Akt and AMPK/SIRT1/PGC1α survival signaling to suppress apoptosis and inflammation in aging hippocampus. (Pubmed Central) - Feb 27, 2021
Fas-dependent and mitochondrial-dependent apoptotic pathways were significantly increased in the induced-aging group relative to the control group whereas they were decreased in the aging-exercise group. This study demonstrated that swimming exercise not only reduced aging-induced brain apoptosis and inflammatory signaling activity, but also enhanced the survival pathways in the hippocampus, which provides one of the new beneficial effects for exercise training in aging brain.
- | U0126 / Promega
Journal: Apelin-13 attenuates high glucose-induced calcification of MOVAS cells by regulating MAPKs and PI3K/AKT pathways and ROS-mediated signals. (Pubmed Central) - Feb 27, 2021
Taken together, these results suggested that apelin-13 had the potential to attenuate high glucose-induced calcification of MOVAS cells by inhibiting ROS-mediated DNA damage and regulating MAPKs and PI3K/AKT pathways. Our findings validated the strategy of using apelin-13 maybe a novel way in treating high glucose-mediated VC.
- | Preclinical, Journal: Salvia miltiorrhiza stems and leaves total phenolic acids combination with tanshinone protect against DSS-induced ulcerative colitis through inhibiting TLR4/PI3K/AKT/mTOR signaling pathway in mice. (Pubmed Central) - Feb 27, 2021
Our findings validated the strategy of using apelin-13 maybe a novel way in treating high glucose-mediated VC. We demonstrated for the first time that, JF and DT alone or in combination effectively ameliorated DSS-induced ulcerative colitis in mice, possibly by inhibiting the TLR4/PI3K/AKT/mTOR signaling pathway.
- | 5-fluorouracil / Generic mfg.
Journal: Hydrazinocurcumin and 5-fluorouracil enhance apoptosis and restrain tumorigenicity of HepG2 cells via disrupting the PTEN-mediated PI3K/Akt signaling pathway. (Pubmed Central) - Feb 27, 2021
Thus, HZC and 5-Fu increase PTEN, which blocks the PI3K/Akt signaling pathway, ultimately inducing HepG2 cell apoptosis. Importantly, the synergistic combination of HZC and 5-Fu may present promising strategy for the treatment of HCC.
- | Preclinical, Journal: Huoxuezhitong capsule ameliorates MIA-induced osteoarthritis of rats through suppressing PI3K/ Akt/ NF-κB pathway. (Pubmed Central) - Feb 27, 2021
Furtherly, in LPS-induced RAW264.7 cells, HXZT could suppress NF-κB via inhibiting PI3K/Akt pathway. Taken together, HXZT capsule could ameliorate MIA-induced osteoarthritis of rats through suppressing PI3K/ Akt/ NF-κB pathway.
- | Preclinical, Journal: Paecilomyces cicadae-fermented Radix astragali activates podocyte autophagy by attenuating PI3K/AKT/mTOR pathways to protect against diabetic nephropathy in mice. (Pubmed Central) - Feb 27, 2021
In summary, RPF has better effect on delaying the development of DN than Radix astragali. RPF enhances autophagy in podocytes and delays DN probably by inhibiting the PI3K/AKT/mTOR signaling pathway.
- || Review, Journal: Marine compounds targeting the PI3K/Akt signaling pathway in cancer therapy. (Pubmed Central) - Feb 27, 2021
The great potential of the development of marine drugs provides a new direction for cancer treatment. This review focuses on marine compounds that target the PI3K/Akt signaling pathway for the prevention and treatment of cancer and provides comprehensive information for those interested in research on marine drugs.
- | Journal: Anthrax lethal factor cleaves regulatory subunits of phosphoinositide-3 kinase to contribute to toxin lethality. (Pubmed Central) - Feb 27, 2021
The LF(W271A) mutant cleaves p85α with lower efficiency and is non-toxic to mice but can regain lethality when combined with PI3K pathway inhibitors. We provide evidence that LF targets two signalling pathways that are essential for growth and metabolism and that the disabling of both pathways is likely necessary for lethal anthrax infection.
- | quercetin (LY294002) / Eli Lilly
Journal: Neuroprotection against cerebral ischemia/reperfusion by dietary phytochemical extracts from Tibetan turnip (Brassica rapa L.). (Pubmed Central) - Feb 27, 2021
AET improved the survival of OGD/R-injured HT-22 cells by activating the PI3K/Akt/mTOR pathway. Based on the results above, aqueous extract of turnip has a protective effect on focal cerebral ischemic injury.
- | Journal: EGFL7 as a novel therapeutic candidate regulates cell invasion and anoikis in colorectal cancer through PI3K/AKT signaling pathway. (Pubmed Central) - Feb 27, 2021
Based on the results above, aqueous extract of turnip has a protective effect on focal cerebral ischemic injury. Overall, our findings suggested that EGFL7 acts as an oncogene, regulated CRC invasion and anoikis through PI3K/AKT signaling, which provided a theoretical basis for EGFL7 as a potential therapeutic target of CRC treatment.
- ||||| Clinical data: Join Drs @BCJoyceO, Matthew Goetz, & Sara Hurvitz on 3/1 at 7:30pm ET for live Webinar on oral therapies for patients with HR+/HER2− breast cancer. The webinar will focus on the latest clinical data, including CDK4/6 and PI3K inhibitors. https://t.co/TUyN0bkRwI. #BreastCancer (Twitter) - Feb 26, 2021
- || Thanks Alex, I have a lot of role models :-) It’s so great seeing you at the PI3K seminars and looking forward to the next @CantleyLab retreat. (Twitter) - Feb 26, 2021
- |||| Amazing talk by Dr. Lewis Cantley @WCM_MeyerCancer who took us to his journey in discovering #PI3K and its implications in human diseases. (Twitter) - Feb 26, 2021
- | Journal: Galectin-1 Overexpression Activates the FAK/PI3K/AKT/mTOR Pathway and Is Correlated with Upper Urinary Urothelial Carcinoma Progression and Survival. (Pubmed Central) - Feb 26, 2021
We concluded that GAL1 expression was highly related to oncological survival in patients with locally advanced UTUC. GAL1 promoted UC invasion and metastasis by activating the FAK/PI3K/AKT/mTOR pathway.
- | Previfenon (epigallocatechin gallate) / MELISA Institute
Journal: The epigallocatechin gallate derivative Y inhibits human hepatocellular carcinoma by inhibiting angiogenesis in MAPK/ERK1/2 and PI3K/AKT/ HIF-1α/VEGF dependent pathways. (Pubmed Central) - Feb 26, 2021
GAL1 promoted UC invasion and metastasis by activating the FAK/PI3K/AKT/mTOR pathway. our work suggests that the new EGCG derivate Y could significantly inhibit tumor growth and angiogenesis which is possibly involved with the signaling intervention of MAPK/ERK1/2 and PI3K/AKT/HIF-1α/VEGF pathways, and is supposed to be a potential therapeutic reagent for anti-angiogenesis treatment of solid tumors.
- | Journal: Artesunate promotes the proliferation of neural stem/progenitor cells and alleviates Ischemia-reperfusion Injury through PI3K/Akt/FOXO-3a/p27 signaling pathway. (Pubmed Central) - Feb 26, 2021
The expression levels of related molecules in PI3K/Akt/FOXO-3a/p27 signaling pathway (p-AKT, p-FOXO-3a, p27) were examined using western blotting. The results suggested ART could inhibit the transcriptional function of FOXO-3a by inducing its phosphorylation, subsequently downregulating p27 and enhancing neural stem cell proliferation in the infarcted cortex via PI3K/AKT signaling, further alleviating ischemia-reperfusion injury after ischemic stroke.
- | Journal: PHLDA2 regulates EMT and autophagy in colorectal cancer via the PI3K/AKT signaling pathway. (Pubmed Central) - Feb 26, 2021
The effects of PHLDA2 on autophagy and EMT were mediated in part via the PI3K/AKT signaling pathway. Taken together, these results suggest that downregulation of PHLDA2 inhibits tumor growth and PI3K, thereby promoting autophagy and inhibiting EMT, in part through the PI3K/AKT/mTOR and PI3K/AKT/GSK-3β signaling pathways.
- | Preclinical, Journal: Portulaca oleracea L. extract reduces hyperglycemia via PI3k/Akt and AMPK pathways in the skeletal muscles of C57BL/Ksj-db/db mice. (Pubmed Central) - Feb 26, 2021
Taken together, these results suggest that downregulation of PHLDA2 inhibits tumor growth and PI3K, thereby promoting autophagy and inhibiting EMT, in part through the PI3K/AKT/mTOR and PI3K/AKT/GSK-3β signaling pathways. These results indicate that POE reduces hyperglycemia by improving insulin resistance through the PI3k/Akt and AMPK pathways in the skeletal muscle of C57BL/Ksj-db/db mice.
- | MK-2206 / Merck (MSD)
Journal: Targeting PI3K and AMPKα Signaling Alone or in Combination to Enhance Radiosensitivity of Triple Negative Breast Cancer. (Pubmed Central) - Feb 26, 2021
Together, our results demonstrate that AMPKα, p110α, and Akt1 promote TNBC proliferation and that Akt1 is a key regulator of radiosensitivity in TNBC. Importantly, combining radiotherapy with the pharmacological inhibition of Akt1 expression is a potentially promising approach for the treatment of TNBC.
- | Sutent (sunitinib) / Pfizer
Journal: Identification of low-dose multidrug combinations for sunitinib-naive and pre-treated renal cell carcinoma. (Pubmed Central) - Feb 26, 2021
We demonstrate a promising low-dose drug combination development to obtain drug combinations effective in naive as well as resistant tumours. Nevertheless, we emphasise the need for further mechanistic investigation and preclinical development.
- | Journal: Anti-breast cancer and toxicity studies of total secondary saponin from Anemone raddeana Rhizome on MCF-7 cells via ROS generation and PI3K/AKT/mTOR inactivation. (Pubmed Central) - Feb 26, 2021
This study demonstrated that TSS exhibited anti-proliferative and pro-apoptosis activities on MCF-7 cells via ROS-mediated activation of mitochondrial apoptosis pathway. TSS might be used as chemotherapeutic agent for the treatment of breast cancer with relatively low toxicity.
- | Stivarga (regorafenib) / Bayer
Preclinical, Journal: Regorafenib is effective against neuroblastoma in vitro and in vivo and inhibits the RAS/MAPK, PI3K/Akt/mTOR and Fos/Jun pathways. (Pubmed Central) - Feb 26, 2021
TSS might be used as chemotherapeutic agent for the treatment of breast cancer with relatively low toxicity. The effects of regorafenib on multiple intracellular signalling pathways and the potential additional efficacy when combined with 13-cis-retinoic acid represent opportunities to develop treatment regimens incorporating regorafenib for children with neuroblastoma.
- | Journal: 10-Gingerol Targets Lipid Rafts Associated PI3K/Akt Signaling in Radio-Resistant Triple Negative Breast Cancer Cells. (Pubmed Central) - Feb 26, 2021
The cholesterol content of the lipid rafts and rafts-resident Akt signaling were also affected by exposure to 10-gingerol. The results of the present study highlight rafts-associated PI3K/Akt signaling as a new target of 10-gingerol in MDA-MB-231/IR cells, thus rationalizing a new rafts-mediated treatment approach for radio-resistant triple negative breast cancer cells.
- | Preclinical, Journal: Wild simulated ginseng activates mouse macrophage, RAW264.7 cells through TRL2/4-dependent activation of MAPK, NF-κB and PI3K/AKT pathways. (Pubmed Central) - Feb 26, 2021
Based on the results of this study, WSG is thought to activate macrophages through the production of immunomodulators and phagocytosis activation through TLR2/4-dependent MAPK, NF-κB and PI3K/AKT signaling pathways. Therefore, it is thought that WSG have the potential to be used as an agent for enhancing immunity.
- || Review, Journal: Inositol Polyphosphate-Based Compounds as Inhibitors of Phosphoinositide 3-Kinase-Dependent Signaling. (Pubmed Central) - Feb 26, 2021
This review summarizes previously published studies that led to the identification of inositol polyphosphates as promising parent molecules to design novel inhibitors of PI3K-dependent signals. We focus our attention on the inhibition of protein-membrane interactions mediated by binding of pleckstrin homology domains and phosphoinositides that we proposed 20 years ago as a novel therapeutic strategy.
- | Journal: Lactate Lights up PI3K Inhibitor Resistance in Breast Cancer. (Pubmed Central) - Feb 26, 2021
In this issue of Cancer Cell, Ros et al. show the utility of noninvasive metabolic imaging of labeled carbon transfer from pyruvate to lactate to detect early response and FOXM1-mediated resistance to PI3K inhibition in estrogen-receptor-positive breast cancer.
- | Journal, IO biomarker: Alkaloids extracted from Uncaria rhynchophylla demonstrate neuroprotective effects in MPTP-induced experimental parkinsonism by regulating the PI3K/Akt/mTOR signaling pathway. (Pubmed Central) - Feb 26, 2021
show the utility of noninvasive metabolic imaging of labeled carbon transfer from pyruvate to lactate to detect early response and FOXM1-mediated resistance to PI3K inhibition in estrogen-receptor-positive breast cancer. These findings provide evidence that URA can effectively protect neurons from the neurotoxicity caused by MPTP in mouse models of PD by up-regulating the PI3K/Akt/mTOR signaling pathway.
- | Koselugo (selumetinib) / Merck (MSD), AstraZeneca, dactolisib (RTB101) / Adicet Bio
Journal: Horizontal Combination of MEK and PI3K/mTOR Inhibition in BRAF Mutant Tumor Cells with or without Concomitant PI3K Pathway Mutations. (Pubmed Central) - Feb 26, 2021
In conclusion, the presence of concurrent mutations alone did not predict a stronger response to combination treatment. Therefore, additional investigations are warranted to identify predictive factors that can select patients who can benefit from the horizontal combinational inhibition of these two pathways.
- | Journal: Glycolysis fuels phosphoinositide 3-kinase signaling to bolster T cell immunity. (Pubmed Central) - Feb 26, 2021
Thus, nutrient metabolism and growth factor signaling are highly integrated processes, with glycolytic ATP serving as a rheostat to gauge PI3K-Akt-Foxo1 signaling in the control of T cell immunity. Such a bioenergetic mechanism for the regulation of signaling may explain the Warburg effect.
- | Previfenon (epigallocatechin gallate) / MELISA Institute
Journal: Epigallocatechin Gallate Protects against MNNG-Induced Precancerous Lesions of Gastric Carcinoma in Rats via PI3K/Akt/mTOR Pathway. (Pubmed Central) - Feb 26, 2021
The apoptotic pathway triggered by EGCG may be related to inhibition of PI3K/Akt/mTOR pathway. It provided a theoretical basis for the PLGC treatment and gastric cancer prevention.
- | Preclinical, Journal: Agriophyllum oligosaccharides ameliorate hepatic injury in type 2 diabetic db/db mice targeting INS-R/IRS-2/PI3K/AKT/PPAR-γ/Glut4 signal pathway. (Pubmed Central) - Feb 25, 2021
It provided a theoretical basis for the PLGC treatment and gastric cancer prevention. The results suggest that AOS could protect the liver in type 2 diabetes, in part by activating insulin in the INS-R/IRS2/PI3K/AKT/Glut4/PPAR-γ signal pathway, facilitating hepatocyte proliferation, and further reducing the blood glucose levels.
- | Journal: A-kinase-interacting protein 1 promotes EMT and metastasis via PI3K/Akt/IKKβ pathway in cervical cancer. (Pubmed Central) - Feb 25, 2021
Our findings indicate that AKIP1 promotes the epithelial-mesenchymal transition and metastasis in CC by activating NF-κB signalling through the PI3K/Akt/IKKβ pathway, suggesting that AKIP1 is a pivotal regulator of an EMT axis in CC. AKIP1 could be implicated as a potential therapeutic target as well as a valuable biomarker for evaluating prognosis for patients with CC.
- | cisplatin / Generic mfg.
Journal: DMBT1 suppresses cell proliferation, migration and invasion in ovarian cancer and enhances sensitivity to cisplatin through galectin-3/PI3k/Akt pathway. (Pubmed Central) - Feb 25, 2021
We demonstrated that DMBT1 might inhibit the progression of ovarian by inhibiting cell proliferation, migration and invasion and increased the sensitivity to cisplatin through galectin-3/PI3K/AKT pathway. The findings ensure the interaction relation between DMBT1 and galectin-3 in OC, providing a novel biological marker for OC and enriching the potential strategies for OC treatment.
- | Journal: MicroRNA miR-212 regulates PDCD4 to attenuate Aβ-induced neurotoxicity via PI3K/AKT signaling pathway in Alzheimer's disease. (Pubmed Central) - Feb 25, 2021
The findings ensure the interaction relation between DMBT1 and galectin-3 in OC, providing a novel biological marker for OC and enriching the potential strategies for OC treatment. All the data in this study revealed that miR-212 modulated PDCD4 to regulate cell proliferation, apoptosis through PI3K/AKT signaling pathway in Aβ-treated SH-SY5Y and IMR-32 cells, and this new regulatory network may provide a novel mechanism of AD.
- | Journal, IO biomarker: Tongmai Yangxin pill reduces myocardial no-reflow by regulating apoptosis and activating PI3K/Akt/eNOS pathway. (Pubmed Central) - Feb 25, 2021
All the data in this study revealed that miR-212 modulated PDCD4 to regulate cell proliferation, apoptosis through PI3K/AKT signaling pathway in Aβ-treated SH-SY5Y and IMR-32 cells, and this new regulatory network may provide a novel mechanism of AD. TMYX attenuates myocardial NR after ischemia and reperfusion by activating the PI3K/Akt/eNOS pathway and regulating apoptosis, further up-regulating NO activity and relaxing coronary microvessels.
- || Previfenon (epigallocatechin gallate) / MELISA Institute
Clinical, Journal: The epigallocatechin gallate derivative Y6 reduces the cardiotoxicity and enhances the efficacy of daunorubicin against human hepatocellular carcinoma by inhibiting carbonyl reductase 1 expression. (Pubmed Central) - Feb 25, 2021
TMYX attenuates myocardial NR after ischemia and reperfusion by activating the PI3K/Akt/eNOS pathway and regulating apoptosis, further up-regulating NO activity and relaxing coronary microvessels. Y6 has the ability to inhibit CBR1 expression through the coordinate inhibition of PI3K/AKT and MEK/ERK signaling, then synergistically enhances the antitumor effect and reduces the cardiotoxicity of DNR.
- | quercetin (LY294002) / Eli Lilly, U0126 / Promega
Journal: Boesenbergia rotunda extract accelerates human keratinocyte proliferation through activating ERK1/2 and PI3K/Akt kinases. (Pubmed Central) - Feb 25, 2021
Nevertheless, data from Transwell migration assay revealed that BR extract did not promote keratinocyte migration. Altogether, we provided more evidence that BR possesses its wound healing-promoting action through the activation of proliferation and survival pathways, and our study suggests that BR is an interesting candidate to be developed as a wound healing-promoting agent.
- | Journal, IO biomarker: Protection against acute cerebral ischemia/reperfusion injury by Leonuri Herba Total Alkali via modulation of BDNF-TrKB-PI3K/Akt signaling pathway in rats. (Pubmed Central) - Feb 25, 2021
Altogether, we provided more evidence that BR possesses its wound healing-promoting action through the activation of proliferation and survival pathways, and our study suggests that BR is an interesting candidate to be developed as a wound healing-promoting agent. The study demonstrated that LHA pre-administration could regulate the PI3K/Akt pathway by increasing BDNF levels, and play a neuroprotective role in cerebral ischemia-reperfusion injury.
- | Journal, IO biomarker: Protective effects of dioscin on vascular remodeling in pulmonary arterial hypertension via adjusting GRB2/ERK/PI3K-AKT signal. (Pubmed Central) - Feb 25, 2021
GRB2 siRNA transfection in PASMCs further confirmed that the inhibitory action of dioscin in PAH was evoked by adjusting GRB2/ERK/PI3K-AKT signal. Taken together, our study indicated that dioscin attenuates PAH through adjusting GRB2/ERK/PI3K-AKT signal to inhibit PASMCs proliferation and migration, and promote apoptosis, and dioscin may be developed as a therapeutic strategy for treating PAH in the future.
- | Journal: Neuregulin-1 converts reactive astrocytes toward oligodendrocyte lineage cells via upregulating the PI3K-AKT-mTOR pathway to repair spinal cord injury. (Pubmed Central) - Feb 25, 2021
Our findings indicate that Nrg1 is sufficient to trans-differentiate reactive astrocytes to oligodendrocytes via the PI3K-AKT-mTOR signaling pathway and repair SCI. Delivery of Nrg1 for the remyelination processes could be a promising strategy for spinal cord repair.
- | Journal: miR-7a Targets Insulin Receptor Substrate-2 Gene and Suppresses Viability and Invasion of Cells in Diabetic Retinopathy Mice via PI3K-Akt-VEGF Pathway. (Pubmed Central) - Feb 25, 2021
Transfection of siRNA targeting IRS-2 caused alteration in miR-7a mediated changes in ECs suggesting that miR-7a may decrease angiogenesis in DR by inhibiting the levels of IRS-2. miR-7a suppresses PI3K/Akt cascade via targeting IRS-2, thus decreasing the viability and invasion capacity of RPs and ECs, suggesting an interesting treatment target for DR.
- quercetin (LY294002) / Eli Lilly
[VIRTUAL] NOX-4 AND SELENIUM INFLUENCES IN THYROID PI3K SIGNALING IN THYROID CELLS. () - Feb 24, 2021 - Abstract #ICE2021ICE_540;
2-IHDA induced akt phosphorylation (1.8 fold, p<0.05), the PI3K inhibitor (LY294002) and Selenium reverted the inhibitory effect of 2-IHDA on NIS and GPx mRNA gene transcription... These results suggest that NOX4 and Selenium plays a critical role in Akt phosphorylation in FRTL-5 cells that influence NIS expression.
- pictilisib (GDC-0941) / Roche
[VIRTUAL] PROLIFERATION AND SURVIVAL OF BREAST CANCER CELLS WERE ENHANCED BY A PESTICIDE, FENHEXAMID, VIA AN ESTROGEN RECEPTOR-DEPENDENT AND PI3K/AKT PATHWAYS () - Feb 24, 2021 - Abstract #ICE2021ICE_435;
The cells were cultured with 0.1% DMSO (control), 17β-estradiol (E2; 1x10-9 M) and Fen (10- 5-10-7 M) in the absence or presence of ICI 182,780 (ICI, ER antagonist, 10-8 M) or Pictilisib (Pic, PI3K inhibitor, 10-7 M)... Taken together, these results indicate that Fen, a pesticide, may induce cancer progression by increasing cell viability and survival via an ER dependent and PI3K/AKT pathways.
- pictilisib (GDC-0941) / Roche
[VIRTUAL] ESTROGEN RECEPTOR-DEPENDENT AND PI3K/AKT PATHWAYS WERE INVOLVED IN BREAST CANCER MIGRATION AND ANGIOGENESIS BY A PESTICIDE, FENHEXAMID () - Feb 24, 2021 - Abstract #ICE2021ICE_434;
The cells were treated with 0.1% DMSO (control), 17β-estradiol (E2; 1x10-9 M) and Fen (10-5- 10-7 M) in the absence or presence of ICI 182,780 (ICI, ER antagonist, 10-8 M) or Pictilisib (Pic, PI3K inhibitor, 10-7 M)... These results imply that Fen may induce breast cancer progression by increasing cell migration and angiogenesis via an ER-dependent and PI3K/AKT pathways.
- | Journal: MiR-340-5p alleviates oxygen-glucose deprivation/reoxygenation-induced neuronal injury via PI3K/Akt activation by targeting PDCD4. (Pubmed Central) - Feb 24, 2021
Collectively, our results indicate that miR-340-5p might exerted neuroprotective effects during OGDR injury by targeting PDCD4 and then activating the PI3K/Akt pathway. These results indicated a novel target for treating cerebral ischemic injury.
- | Journal: An Excitable Ras/PI3K/ERK Signaling Network Controls Migration and Oncogenic Transformation in Epithelial Cells. (Pubmed Central) - Feb 24, 2021
Wave activity was progressively enhanced across a series of increasingly metastatic breast cancer cell lines. The view that oncogenic transformation is a shift to a lower threshold of excitable Ras/PI3K/ERK network, caused by various combinations of genetic insults, can facilitate the assessment of cancer severity and effectiveness of interventions.
- | Journal: Peroxisome Proliferator-Activated Receptor γ Coactivator 1α Activates Vascular Endothelial Growth Factor That Protects Against Neuronal Cell Death Following Status Epilepticus through PI3K/AKT and MEK/ERK Signaling. (Pubmed Central) - Feb 24, 2021
These results may indicate that the PGC-1α induced VEGF/VEGFR2 pathway may trigger the neuronal survival signaling, and the PI3K/AKT and MEK/ERK signaling pathways. Thus, the axis of PGC-1α/VEGF/VEGFR2 (Flk-1) and the triggering of downstream PI3K/AKT and MEK/ERK signaling could be considered an endogenous neuroprotective effect against apoptosis in the hippocampus following status epilepticus.