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- | quercetin (LY294002) / Eli Lilly
Journal: A recombinant Chinese measles virus vaccine strain rMV-Hu191 inhibits human colorectal cancer growth through inducing autophagy and apoptosis regulating by PI3K/AKT pathway. (Pubmed Central) - Apr 14, 2021
And inhibition of PI3K/AKT pathway using LY294002 was accompanied by enhanced apoptosis and decreased autophagy which suggested that PI3K/AKT pathway promoted rMV-Hu191-induced autophagy and inhibited rMV-Hu191-induced apoptosis...As part of the underlying cellular mechanisms, apoptosis and autophagy were involved in the oncolytic effects generated by rMV-Hu191. And the cross-talk between these two processes and the PI3K/AKT signaling pathway was well identified.
- | quercetin (LY294002) / Eli Lilly, PD98059 / Wayne State University
Preclinical, Journal: In vitro phagocytosis of liquid-stored red blood cells requires serum and can be inhibited with fucoidan and dextran sulphate. (Pubmed Central) - Apr 13, 2021
RBCs damaged during liquid storage may be recognized by macrophage SR-A and serum-dependent mechanisms. This species-independent recognition mechanism may help to further understand the rapid clearance of stored RBCs shortly after transfusion.
- | Journal, Cancer stem cells: PIK3C3 regulates the expansion of liver CSCs and PIK3C3 inhibition counteracts liver cancer stem cell activity induced by PI3K inhibitor. (Pubmed Central) - Apr 13, 2021
Although PIK3C3 plays a critical role in autophagy, we find that PIK3C3 regulates liver CSCs independent of the autophagy process. These findings uncover the effective suppression of liver CSCs by targeting PIK3C3, and targeting PIK3C3 in combination with PI3K inhibitor inhibits the expansion of liver CSCs efficiently, which is an attractive therapeutic regimen for the treatment of HCC.
- | sirolimus / Generic mfg.
Journal: Ginsenoside Rg3 promotes regression from hepatic fibrosis through reducing inflammation-mediated autophagy signaling pathway. (Pubmed Central) - Apr 13, 2021
Taken together, G-Rg3 exerted anti-fibrosis effect through the inhibition of autophagy in TAA-treated mice and LPS-stimulated HSC-T6 cells. These data collectively unravel that G-Rg3 may serve a promising anti-hepatic fibrosis drug.
- | Journal: Oncogene PRR14 promotes breast cancer through activation of PI3K signal pathway and inhibition of CHEK2 pathway. (Pubmed Central) - Apr 13, 2021
Collectively, our study is the first to document the oncogenetic role of PRR14 in breast cancer, which protects cells from apoptosis and stimulates proliferation by activating the PI3-kinase/Akt/mTOR pathway and inhibiting the CHEK2 pathway. Both of these pathways are of great influence in breast cancer and PRR14 appears to be their novel interacting node, which renders patients more resistance to chemotherapy and provides a potential therapeutic target in breast cancer.
- | Journal: LncRNA HAND2-AS1 inhibits proliferation and promotes apoptosis of non-small cell lung cancer cells by inactivating PI3K/Akt pathway. (Pubmed Central) - Apr 13, 2021
Both of these pathways are of great influence in breast cancer and PRR14 appears to be their novel interacting node, which renders patients more resistance to chemotherapy and provides a potential therapeutic target in breast cancer. we conclude that HAND2-AS1 may suppress the proliferation of NSCLC cells by targeting PI3K/Akt pathway.
- | Journal: Deficiency of C-X-C chemokine receptor type 5 (CXCR5) gene causes dysfunction of retinal pigment epithelium cells. (Pubmed Central) - Apr 13, 2021
Inhibition of FOXO1, however, reverts the degradation of ZO-1 caused by CXCR5 deficiency. Collectively, these findings suggest that CXCR5 maintains PI3K/AKT signaling, which controls FOXO1 activation, thereby regulating the expression of genes involved in RPE EMT and autophagy deregulation.
- | cisplatin / Generic mfg.
Journal, PD(L)-1 Biomarker, IO biomarker: Circadian rhythm and Period2 regulate the chemotherapy effect and multidrug resistance of ovarian cancer through PI3K signaling pathway. (Pubmed Central) - Apr 13, 2021
Methylation of CpG islands in the promoter of Per2 could result in its decreased expression in SKOV3/DDP（Cisplatin） cells. Dysrhythmia of the circadian clock: (i) had a negative effect on the chemotherapy effect against ovarian cancer; (ii) affected expression of immune factors and the phosphoinositide 3-kinase/protein kinase B (PI3K/Akt) signaling pathway. The Per2 gene can affect the drug resistance of ovarian cancer by inhibiting the PI3K/Akt signaling pathway and then acting on its downstream drug-resistance factors, thereby providing a new target for ovarian-cancer treatment.
- | Journal, PARP Biomarker, IO biomarker: The Flavonol Isoquercitrin Promotes Mitochondrial-Dependent Apoptosis in SK-Mel-2 Melanoma Cell via the PI3K/AKT/mTOR Pathway. (Pubmed Central) - Apr 13, 2021
The anti-proliferative activity of IQ against SK-MEL-2 can also be attributed to the downregulation of the PI3K/AktmTOR signaling pathway. These findings showed that IQ can be developed into a chemopreventive therapeutic agent against the melanoma cells.
- | Preclinical, Journal: Imperatorin alleviated endometriosis by inhibiting the activation of PI3K/Akt/NF-κB pathway in rats. (Pubmed Central) - Apr 13, 2021
These findings showed that IQ can be developed into a chemopreventive therapeutic agent against the melanoma cells. Our findings revealed that imperatorin is a significant multi-target natural active ingredient for treatment endometriosis.
- | quercetin (LY294002) / Eli Lilly
Journal: Gigantol inhibits proliferation and enhances DDP-induced apoptosis in breast-cancer cells by downregulating the PI3K/Akt/mTOR signaling pathway. (Pubmed Central) - Apr 13, 2021
Our data might provide new insights into the underlying antitumor effect of gigantol in BC cells. This enhancement effect in the combination of gigantol and DDP may provide many therapeutic benefits in clinical treatment regimens against BC.
- | dactolisib (RTB101) / Adicet Bio
Journal: The oncogene AAMDC links PI3K-AKT-mTOR signaling with metabolic reprograming in estrogen receptor-positive breast cancer. (Pubmed Central) - Apr 13, 2021
Lastly, we provide evidence that AAMDC can interact with the RabGTPase-activating protein RabGAP1L, and that AAMDC, RabGAP1L, and Rab7a colocalize in endolysosomes. The discovery of the RabGAP1L-AAMDC assembly platform provides insights for the design of selective blockers to target malignancies having the AAMDC amplification.
- | Journal: SET Domain-Containing Protein 5 Enhances the Cell Stemness of Non-Small Cell Lung Cancer via the PI3K/Akt/mTOR Pathway. (Pubmed Central) - Apr 13, 2021
The discovery of the RabGAP1L-AAMDC assembly platform provides insights for the design of selective blockers to target malignancies having the AAMDC amplification. In this study, SETD5 promoted the cancer stem cell property of NSCLC through mitigating the activation of the PI3K/Akt/mTOR pathway, suggesting a candidate target role for SETD5 in NSCLC treatment.
- | Aliqopa (copanlisib) / Bayer, Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
Journal: NHL Progression Risk Cut with Copanlisib-Rituximab Combo. (Pubmed Central) - Apr 13, 2021
According to results from the phase III CHRONOS-3 trial, patients with relapsed indolent non-Hodgkin lymphoma may benefit significantly from the addition of copanlisib, a pan-PI3K inhibitor, to standard rituximab. The combination was safe and nearly halved the risk of disease progression or death, compared with placebo and rituximab.
- | chloroquine phosphate / Generic mfg.
Journal: Fisetin inhibits inflammation and induces autophagy by mediating PI3K/AKT/mTOR signaling in LPS-induced RAW264.7 cells. (Pubmed Central) - Apr 13, 2021
Western blot analysis and immunofluorescence assay showed that fisetin decreased microtubule-associated protein 1 light-chain 3B (LC3B) and lysosome-associated membrane protein 1 (LAMP1) expression in LPS-treated cells, while the autophagy inhibitor chloroquine (CQ) could partially reverse this effect...Fisetin diminished the expression and secretion of inflammatory cytokines and facilitated autophagosome-lysosome fusion and degradation in LPS-treated RAW264.7 cells via inhibition of the PI3K/AKT/mTOR signaling pathway. Overall, the results of this study provide new clues for the anti-inflammatory mechanism of fisetin and explain the crosstalk between autophagy and inflammation to some extent.
- | Journal: Upregulation of circRNA_100395 sponges miR-142-3p to inhibit gastric cancer progression by targeting the PI3K/AKT axis. (Pubmed Central) - Apr 13, 2021
These findings also showed that miRNA-142-3p rescued the antitumor effects induced by circRNA_100395-overexpression. cirRNA_100395-overexpression had antitumor effects via regulating the miR-142-3p signaling pathway, which might be a promising treatment target for GC.
- | Journal: Heregulin-β1 Activates NF-E2-related Factor 2 and Induces Manganese Superoxide Dismutase Expression in Human Breast Cancer Cells via Protein Kinase B and Extracellular Signal-regulated Protein Kinase Signaling Pathways. (Pubmed Central) - Apr 13, 2021
The pharmacological inhibitors of phosphatidylinositol 3-kinase and mitogen-activated protein kinase kinase 1/2, which are upstream of Akt and ERK, respectively, attenuated heregulin-β1-induced MnSOD expression and nuclear localization of Nrf2. In conclusion, heregulin-1 induces upregulation of MnSOD and activation of Nrf2 via the Akt and ERK signaling in MCF-7 cells, which may confer metastatic potential and invasiveness of these cells.
- | epirubicin / Generic mfg.
Journal, IO biomarker: PIK3CA mutation confers resistance to chemotherapy in triple-negative breast cancer by inhibiting apoptosis and activating the PI3K/AKT/mTOR signaling pathway. (Pubmed Central) - Apr 13, 2021
Epirubicin was used as the chemotherapeutic agent...Moreover, prognostic analysis of 50 patients with TNBC indicated that PIK3CA mutation might be linked with relapse and death. PIK3CA mutation confers resistance to chemotherapy in TNBC by inhibiting apoptosis and activating the PI3K/AKT/mTOR signaling pathway.
- | TL117 / Suzhou Junde Biotechnology
New P1/2 trial, Combination therapy, Metastases: Study of TL117 in Patients With Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma (clinicaltrials.gov) - Apr 12, 2021
P1/2, N=108, Not yet recruiting, Sponsor: Suzhou Junde Biotechnology Co., Ltd
- ||| Aliqopa (copanlisib) / Bayer
全ての種類のインドレント非ホジキンリンパ腫に対して、リツキシマブとの併用でPI3K阻害薬の有効性が初めて示されました。 #AACR21 #リンパ腫 #インドレント非ホジキンリンパ腫 #copanlisib https://t.co/EVdZ3vkdSS (Twitter) - Apr 11, 2021
- | The usual Sunday list of #PI3K research and beyond. Thanks to the pre-sort of @BiomedNew! Enjoy :-) https://t.co/Jys4T7NbvD (Twitter) - Apr 11, 2021
- Ukoniq (umbralisib) / TG Therap
[VIRTUAL] UMBRALISIB IMPROVES TOLERABILITY AND ASSOCIATED COST BURDEN OF ADVERSE EVENTS OVER PI3K INHIBITORS IN RELAPSED/ REFRACTORY (R/R) FOLLICULAR LYMPHOMA (FL) PATIENTS: RESULTS FROM MATCHING-ADJUSTED INDIRECT COMPARISON () - Apr 11, 2021 - Abstract #AMCP2021AMCP_76;
P2b
PIK3CA mutation confers resistance to chemotherapy in TNBC by inhibiting apoptosis and activating the PI3K/AKT/mTOR signaling pathway. In an indirect treatment comparison accounting for differences in cross-trial characteristics, umbralisib demonstrated significantly lower AE discontinuations (~3 times lower), favorable DoR, and a lower AE management cost burden (>2 times lower) than currently approved PI3Kis for R/R FL patients.
- | Journal: SOX4 and SMARCA4 cooperatively regulate PI3k signaling through transcriptional activation of TGFBR2. (Pubmed Central) - Apr 11, 2021
We further report that SOX4 and the SWI/SNF ATPase SMARCA4, which are uniformly overexpressed in basal-like tumors, form a previously unreported complex that is required to maintain an open chromatin conformation at the TGFBR2 regulatory regions in order to mediate TGFBR2 expression and PI3K signaling. Collectively, our findings delineate the mechanism by which SOX4 and SMARCA4 cooperatively regulate PI3K/Akt signaling and suggest that this complex may play an essential role in TNBC genesis and/or progression.
- ||||| Aliqopa (copanlisib) / Bayer, Rituxan (rituximab) / Biogen, Zenyaku Kogyo, Roche
Clinical: At #AACR21 @DrMatasar concluded that copanlisib+rituximab had superior efficacy over rituximab in rel iNHL. Copanlisib is the first PI3K inhibitor to be safely combined with rituximab in iNHL Copanlisib + rituximab presents a new treatment option in rel iNHL. #lymsm #lymphoma (Twitter) - Apr 10, 2021
- || Great point; do you have a sense @DrMatasar of how much R added to PI3K (esp. w/ progression on prior R)? (Twitter) - Apr 10, 2021
- | clarithromycin / Generic mfg.
Journal: Clarithromycin inhibits autophagy in colorectal cancer by regulating the hERG1 potassium channel interaction with PI3K. (Pubmed Central) - Apr 10, 2021
We conclude that Cla affects the autophagic flux by impairing the signaling pathway linking hERG1 and PI3K. Combining Cla with 5-FU might be a novel therapeutic option in CRC.
- | Journal: MiR-145 reduces the activity of PI3K/Akt and MAPK signaling pathways and inhibits adipogenesis in bovine preadipocytes. (Pubmed Central) - Apr 10, 2021
Furthermore, insulin, as a powerful inducer initiating adipogenesis and an activator of the PI3K/Akt and MAPK signaling pathways, was able to rescue the downregulation of Akt and ERK1/2 phosphorylation levels caused by miR-145. Taken together, our findings suggest that miR-145 is a potent inhibitor of adipogenesis that may function by reducing the activity of PI3K/Akt and MAPK signaling pathways.
- | Journal: Inhibition of PI3K/AKT molecular pathway mediated by membrane estrogen receptor GPER accounts for cryptotanshinone induced antiproliferative effect on breast cancer SKBR-3 cells. (Pubmed Central) - Apr 10, 2021
The current study showed that the antiproliferative action of CPT on SKBR-3 cells was realized by inhibition of GPER mediated PI3K/AKT pathway. These findings provide further validation of GPER serving as useful therapeutic target.
- | Journal: The novel miR-1269b-regulated protein SVEP1 induces hepatocellular carcinoma proliferation and metastasis likely through the PI3K/Akt pathway. (Pubmed Central) - Apr 10, 2021
SVEP1 could serve as a promising prognostic marker of HCC. MiR-1269b downregulates SVEP1 expression and promotes HCC proliferation and metastasis likely through the PI3k/Akt signaling pathway.
- | Zyclara (imiquimod) / Mochida, Mylan, Bausch Health, quercetin (LY294002) / Eli Lilly
Preclinical, Journal: 18β-Glycyrrhetinic acid induces human HaCaT keratinocytes apoptosis through ROS-mediated PI3K-Akt signaling pathway and ameliorates IMQ-induced psoriasis-like skin lesions in mice. (Pubmed Central) - Apr 10, 2021
MiR-1269b downregulates SVEP1 expression and promotes HCC proliferation and metastasis likely through the PI3k/Akt signaling pathway. GA inhibits proliferation and induces apoptosis in HaCaT keratinocytes through ROS-mediated inhibition of PI3K-Akt signaling pathway, and ameliorates IMQ-induced psoriasis-like skin lesions in mice.
- | Journal: MiT/TFE factors control ER-phagy via transcriptional regulation of FAM134B. (Pubmed Central) - Apr 10, 2021
Notably, FAM134B is required for protein secretion in chondrocytes, and cartilage growth and bone mineralization in medaka fish. This study identifies a new signaling pathway that allows ER-phagy to respond to both metabolic and developmental cues.
- | Lynparza (olaparib) / Merck (MSD), AstraZeneca
Journal, BRCA Biomarker, PARP Biomarker: ClC-3/SGK1 regulatory axis enhances the olaparib-induced antitumor effect in human stomach adenocarcinoma. (Pubmed Central) - Apr 10, 2021
Altogether, our findings illustrate that olaparib exerts antitumor effect in human STAD, and ClC-3/SGK1 regulatory axis enhances the olaparib-induced antitumor effect. Up-regulation of the ClC-3/SGK1 axis may provide promising therapeutic potential for the clinical application of olaparib in STAD treatment.
- | Journal: HPV E7-mediated NCAPH ectopic expression regulates the carcinogenesis of cervical carcinoma via PI3K/AKT/SGK pathway. (Pubmed Central) - Apr 10, 2021
In conclusion, our results revealed the role of NCAPH in the carcinogenesis of cervical cancer in vitro and in vivo. The interaction between E7 and NCAPH expands the mechanism of HPV induced tumorigenesis and that of host genes regulating HPV E7.
- | sirolimus / Generic mfg.
Journal: LPAR5 Promotes Thyroid Carcinoma Cells Proliferation and Migration by Activating Class IA PI3K Catalytic Subunit p110β. (Pubmed Central) - Apr 10, 2021
We also found that LPAR5-specific antagonist TC LPA5 4, PI3K inhibitor wortmannin, or mTOR inhibitor rapamycin pretreatment abrogated phosphorylation of Akt and p70S6K1 stimulated by LPA in CGTH-W3 and TPC-1 cells...Overall, we provide new insights that the downregulation of LPAR5 decreased the proliferation and migration phenotype via the PI3K/Akt pathway. Inhibition of LPAR5 or PI3K/Akt signal may be the novel therapeutic strategy for treating thyroid cancer.
- | Biomarker, Preclinical, Journal: A novel gastroprotective effect of zeaxanthin against stress-induced gastritis in male rats targeting the expression of HIF-1α, TFF1 and MMP-9 through PI3K/Akt/JNK signaling pathway. (Pubmed Central) - Apr 10, 2021
These all positive effects of ZE reflected on reduction of microscopic gastric mucosal damage and inflammatory cell infiltration with improvement of ulcer score index. Our results discover a new gastroprotective effect of ZE against stress-induced gastritis in rats mainly via its antioxidative and anti-inflammatory effects which reflected on regulating MMP-9 and HIF-1α signaling pathway.
- ||| Add-On PI3K Inhibitor Wins in Relapsed, Indolent NHL. #lymphoma #lysm @DrMatasar @AACR #AACR21 https://t.co/IvAD8rrjxG (Twitter) - Apr 10, 2021
- ||||| Jakafi oral (ruxolitinib) / Novartis, Incyte, parsaclisib (INCB50465) / Incyte
Clinical: Hello #AACR21! E-poster sessions open at 8:30 a.m. EDT. Don’t miss @AYACOUB7 presenting “A Phase 3, Randomized, Double-Blind, Placebo-Controlled Study of Ruxolitinib Plus Parsaclisib in Patients with JAK- and PI3K-Inhibitor Treatment-Naïve Myelofibrosis.” https://t.co/kN0iz5Dl3m (Twitter) - Apr 10, 2021
- | Journal: LINC00657 promotes the development of colon cancer by activating PI3K/AKT pathway. (Pubmed Central) - Apr 10, 2021
The Publisher apologizes for any inconvenience this may cause. https://www.europeanreview.org/article/16042.
- | Journal: Macrophage MSR1 promotes BMSC osteogenic differentiation and M2-like polarization by activating PI3K/AKT/GSK3β/β-catenin pathway. (Pubmed Central) - Apr 7, 2021
Our findings revealed a previously unrecognized function of MSR1 in macrophages during fracture repair. Targeting MSR1 might, therefore, be a new therapeutic strategy for fracture repair.
- | Journal: Rian/miR-210-3p/Nfkb1 feedback loop promotes hypoxia-induced cell apoptosis in myocardial infarction via deactivating PI3K/Akt signaling pathway. (Pubmed Central) - Apr 7, 2021
Further, rescue assays revealed that Nfkb1 and PI3K/Akt pathway both engaged in the Rian-mediated cell proliferation and apoptosis in hypoxia-treated H9c2 cells. In conclusion, Rian/miR-210-3p/Nfkb1 feedback loop enhances hypoxia-induced cell apoptosis in MI via deactivating PI3K/Akt pathway.
- | Journal: Long Non-coding RNA THRIL Mediates Cell Growth and Inflammatory Response of Fibroblast-Like Synoviocytes by Activating PI3K/AKT Signals in Rheumatoid Arthritis. (Pubmed Central) - Apr 7, 2021
Moreover, the reduced THRIL remarkably reduced the expression of p-PI3K and p-AKT (p < 0.05) in TNF-α-treated RA-FLSs. The present study revealed that THRIL could regulate cell growth and inflammatory response of FLSs by activating the PI3K/AKT signaling pathway, subsequently playing important roles in promoting the occurrence and development of RA.
- | Journal: Cyanidin-3-O-Glucoside Attenuates Lipopolysaccharide-Induced Inflammation in Human Corneal Epithelial Cells by Inducing Let-7b-5p-Mediated HMGA2/PI3K/Akt Pathway. (Pubmed Central) - Apr 7, 2021
It was inferred that the C3G could ameliorate the LPS-induced disorders in HCECs. The effect depended on the induced level of let-7b-5p, which then inhibited HMGA2/PI3K/Akt pathway.
- |||| Clinical: 👏👏 wow!! Excellent paper and analysis @AzadOncology about PI3K and AR pathway correlation in mCRPC pts more if CNVs were easily detected by cfDNA!! ..what about in mCSPC or HR-LAPC setting? @neerajaiims @shilpaonc @NazliDizman (Twitter) - Apr 7, 2021
- | Journal: NLRC3 inhibits PDGF-induced PASMCs proliferation via PI3K-mTOR pathway. (Pubmed Central) - Apr 7, 2021
Our data suggest that PDGF can induce abnormal proliferation of PASMCs, and NLRC3 suppresses activation of the PI3K-mTOR signaling thus inhibits PASMCs proliferation. These findings unveiled the effect of NLRC3 as an inhibitor of the PI3K-mTOR pathway mediating protection against PASMCs proliferation.
- | quercetin (LY294002) / Eli Lilly
Journal: HBSP protects cardiomyocytes from hypoxia/reoxygenation-induced autophagy through the PI3K/Akt pathway. (Pubmed Central) - Apr 7, 2021
HBSP inhibits excessive autophagy and apoptosis induced by H/R by activating the PI3K/Akt pathway. HBSP may potentially be a therapeutic intervention for myocardial ischemia/reperfusion injury.
- | sirolimus / Generic mfg.
Journal: Mibefradil alleviates high glucose-induced cardiac hypertrophy by inhibiting PI3K/Akt/mTOR-mediated autophagy. (Pubmed Central) - Apr 7, 2021
In conclusion, mibefradil ameliorated high-glucose-induced cardiac hypertrophy by activating the PI3K/Akt/mTOR pathway and inhibiting excessive autophagy. Our study suggests that mibefradil can be used therapeutically to ameliorate cardiac hypertrophy in patients with DM.
- | Journal: miR-34a/c induce caprine endometrial epithelial cell apoptosis by regulating circ-8073/CEP55 via the RAS/RAF/MEK/ERK and PI3K/AKT/mTOR pathways. (Pubmed Central) - Apr 7, 2021
miR-34a/c regulated the levels of RE marker genes, including forkhead box M1, vascular endothelial growth factor, and osteopontin (OPN). These results suggest that miR-34a/c not only induce CEEC apoptosis by binding to circ-8073 and CEP55 via the RAS/RAF/MEK/ERK and PI3K/AKT/mTOR pathways, but may also regulate RE establishment in dairy goats.
- | quercetin (LY294002) / Eli Lilly
Journal: FoxA2 inhibits the proliferation of hepatic progenitor cells by reducing PI3K/Akt/HK2-mediated glycolysis. (Pubmed Central) - Apr 7, 2021
Blocking the PI3K/Akt pathway by Ly294002 inhibited HK2 activities, aerobic glycolysis, and cell proliferation in FoxA2-knockdown cells. Therefore, FoxA2 plays an important role in the proliferation and inhibition of HPCs by suppressing PI3K/Akt/HK2-regulated aerobic glycolysis.
- | Journal: Paeoniflorin promotes angiogenesis and tissue regeneration in a full-thickness cutaneous wound model through the PI3K/AKT pathway. (Pubmed Central) - Apr 7, 2021
In summary, the capacity for angiogenesis in endothelial cells could be enhanced by PF treatment via the PI3K/AKT pathway in vitro and could accelerate the wound healing process in vivo through collagen deposition and angiogenesis in regenerated tissue. This study provides evidence that application of PF represents a novel therapeutic approach for the treatment of cutaneous wounds.