COX inhib 
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  • ||||||||||  aspirin / Generic mfg.
    Mechanisms behind the increased risk of Venous Thromboembolism in Klinefelter Syndrome (301A) -  Mar 12, 2024 - Abstract #AUA2024AUA_3355;    
    Understanding these elements is vital, as it could pave the way for effective prophylaxis for this patient group, for example, through the use of anti-platelets such as Aspirin (COX inhibitor). Further research is crucial to pinpoint the exact interplay of these factors with TRT, to help guide the development of targeted strategies for patients with KS.
  • ||||||||||  De novo drug design of DNMT1 inhibitors (Virtual; Virtual Session (Virtual Only)) -  Mar 12, 2024 - Abstract #ACSSp2024ACS_Sp_12544;    
    Ligand-based and structure-based approaches are being considered as a strategy to compare both methods using different fragment libraries. Techniques, including molecular docking and classification models, are contemplated as a consensus evaluation of the designed structures.
  • ||||||||||  imipramine / Generic mfg., ketamine / Generic mfg.
    Preclinical, Journal:  Cyclooxygenase-2 inhibition affects the ratio of GluN2A/GluN2B receptor subunits through interaction with mGluR5 in the mouse brain. (Pubmed Central) -  Mar 11, 2024   
    Compounds that act by influencing NMDARs have been particularly intensively investigated following the success of ketamine in clinics...The side effects associated with imipramine administration, e.g., memory impairment, were improved when inhibiting COX-2...The observed effects were more potent when COX-2 was inhibited. The finding described here may be vital when searching for new drugs acting via NMDARs without the side effects related to cognition.
  • ||||||||||  Needle biopsy induces pro-metastatic progression and systemic dissemination of estrogen receptor-positive breast cancer cells through the COX-2/PGE2 cascade (Section 11) -  Mar 5, 2024 - Abstract #AACR2024AACR_8702;    
    We show that needle biopsy promotes systemic dissemination of cancer cells through a mechanism of sustained activation of the cyclooxygenase-2 (COX-2)/prostaglandin E2 (PGE2) cascade, which favors M2-polarization and its associated pro-metastatic changes, but are abrogated by oral treatment with COX-2 inhibitors in estrogen receptor-positive (ER+) syngeneic mouse tumor models.Therefore, we conclude that needle biopsy of ER+ breast cancer provokes progressive pro-metastatic changes, which may explain the mortality risk posed by surgery delay after diagnosis. Also, our data may provide a rationale for a pharmacologic strategy to inhibit the COX-2/PGE2 cascade in cases when delay of surgery is unavoidable.
  • ||||||||||  eltanexor (KPT-8602) / Ono Pharma, Karyopharm
    Effect of XPO1 inhibition on colorectal cancer tumorigenesis (Section 29) -  Mar 5, 2024 - Abstract #AACR2024AACR_4090;    
    Collectively, our findings underscore XPO1 as a potent target for inhibiting CRC tumorigenesis. Future studies will aim to further assess how Eltanexor is impacting COX-2's promoter, while additionally testing Eltanexor's tumorigenesis-inhibiting potential in a colitis-induced CRC mouse model.
  • ||||||||||  piroxicam / Generic mfg.
    Journal:  Do COX-inhibitors improve emergency contraception efficacy? (Pubmed Central) -  Mar 1, 2024   
    Oral emergency contraception with levonorgestrel plus piroxicam: a randomised double-blind placebo-controlled trial [correction appears in Lancet 2023;402:850]. Lancet 2023;402:851-8.
  • ||||||||||  Review, Journal:  Anti-seizure Effects and Mechanisms of Berberine: A Systematic Review. (Pubmed Central) -  Feb 22, 2024   
    BBR indicated promising anti-seizure effects with remarkable antioxidant, antiinflammatory, anti-apoptotic, and neuroprotective activity. Future studies should be based on well-designed clinical trial studies that are integrated with new methods related to increasing bioavailability.
  • ||||||||||  Journal:  Valvular Prostaglandins Are Elevated in Severe Human Aortic Valve Stenosis. (Pubmed Central) -  Feb 15, 2024   
    Our comprehensive analysis of oxylipins in the human AV identified the inflammatory and osteogenic regulating prostanoids to be positively correlated with AVS severity. This elucidation of prostanoid dysregulation warrants further research into COX inhibition to mitigate AVS.
  • ||||||||||  ketorolac / Generic mfg., morphine sulphate / Generic mfg.
    Preclinical, Journal:  The Inhibitory Effect of NSAIDs and Opioids on Spinal Fusion: An animal model. (Pubmed Central) -  Feb 13, 2024   
    Administration of opioids resulted in the lowest rate of spinal fusion. We propose this may be due to the inhibition of VEGF-A, which limits angiogenesis to the burgeoning fusion mass.
  • ||||||||||  Preclinical, Journal:  Ginsenoside Rk3 Ameliorates Obesity-Induced Colitis by Modulating Lipid Metabolism in C57BL/6 Mice. (Pubmed Central) -  Feb 1, 2024   
    Rk3 intervention markedly reduced the production of pro-inflammatory factors (PGE2, PGD2, TXB2, HETE, and HODE) by inhibiting cyclooxygenase and lipoxygenase pathways, while enhancing the production of anti-inflammatory factors (EET and diHOME) via cytochrome P450 pathways. Our findings suggest that Rk3 is a potential anti-inflammatory natural drug that can improve obesity-induced intestinal inflammation by regulating lipid metabolism.
  • ||||||||||  aspirin / Generic mfg., indomethacin / Generic mfg.
    Journal:  Association between serum prostacyclin and cerebrovascular reactivity in healthy young and older adults. (Pubmed Central) -  Jan 29, 2024   
    The acceptance of combined strategies in the real world has increased, and the occurrence of SAP has decreased annually. What is the relationship between prostacyclin and cerebrovascular reactivity to hypercapnia before and after administration of a cyclooxygenase inhibitor, indomethacin, in healthy young and older adults?...This study evaluated the relationship between a platelet inhibitor, prostacyclin, and cerebrovascular reactivity (CVR) in healthy young (n
  • ||||||||||  Review, Journal:  Prostanoids in Cardiac and Vascular Remodeling. (Pubmed Central) -  Jan 25, 2024   
    Indeed, prostanoids play an important role in modulating structural and functional changes occurring in the myocardium and in the vasculature in response to physiological and pathological stimuli. This review will summarize current knowledge of the role of the different prostanoids in myocardial and vascular remodeling and explore how maladaptive remodeling can be counteracted by targeting specific prostanoids.
  • ||||||||||  ibuprofen / Generic mfg.
    Clinical, Journal:  Trial of Selective Early Treatment of Patent Ductus Arteriosus with Ibuprofen. (Pubmed Central) -  Jan 24, 2024   
    The risk of death or moderate or severe bronchopulmonary dysplasia at 36 weeks of postmenstrual age was not significantly lower among infants who received early treatment with ibuprofen than among those who received placebo. (Funded by the National Institute for Health Research Health Technology Assessment Programme; Baby-OSCAR ISRCTN Registry number, ISRCTN84264977.).
  • ||||||||||  Journal:  Synthesis and anti-inflammatory activity of novel firocoxib analogues with balanced COX inhibition. (Pubmed Central) -  Jan 17, 2024   
    Inhibition of COX enzymes by 9d in lipopolysaccharide (LPS)-stimulated murine RAW264.7 macrophages resulted in the suppression of the NF-?B signaling pathway to reduced expression of pro-inflammatory factors such as inducible nitric oxide synthase (iNOS), COX-2, nitric oxide (NO), and reactive oxygen species (ROS). The remarkable in
  • ||||||||||  ketorolac / Generic mfg., indomethacin / Generic mfg., omeprazole / Generic mfg.
    Journal:  Neuropeptide W facilitates chronic gastric ulcer healing by the regulation of cyclooxygenase and NF-?B signaling pathways. (Pubmed Central) -  Jan 16, 2024   
    Similar findings have already been described with regard to COX-inhibition in depression and schizophrenia. In conclusion, NPW facilitated the healing of gastric injury in rats via the inhibition of pro-inflammatory cytokine production, oxidative stress and neutrophil infiltration as well as the downregulation of COX-2 protein and NF-?B gene expressions.
  • ||||||||||  Relafen (nabumetone) / GSK
    Journal:  Dissecting CYP1A2 Activation by Arylalkanoic Acid Prodrugs toward the Development of Anti-Inflammatory Agents. (Pubmed Central) -  Jan 15, 2024   
    On the basis of these findings, it is possible to argue that subtle differences in the way CYP1A2 accommodates the ligands depend on the fine details of their molecular structures. Overall, these data suggest that compounds simply formed by an aromatic moiety bearing an appropriate alkane-derived chain could lead to innovative anti-inflammatory agents.