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  • ||||||||||  Journal:  Mechanisms involved in the muscle relaxing effects of STW 5 in guinea pig stomach. (Pubmed Central) -  Oct 17, 2024   
    STW 5 inhibited SOCE, most likely ORAI channels, which are modulated by IP3- and PKC-dependent mechanisms. Our findings impact on the design of drugs to induce muscle relaxation and help identify phytochemicals with similar modes of actions to treat gastrointestinal disturbances.
  • ||||||||||  Review, Journal:  Some Aspects and Convergence of Human and Veterinary Drug Repositioning. (Pubmed Central) -  Sep 29, 2024   
    Oncology is one of the disease areas where this platform can significantly support the development of new drugs for human and dog (or other companion animals) anticancer therapies. As an example of the utilization of human and veterinary drugs for veterinary repositioning, the use of COX inhibitors to treat dog cancers is reviewed.
  • ||||||||||  aspirin / Generic mfg.
    A DRAMATIC RESPONSE TO ANTIFUNGAL THERAPY IN A PATIENT WITH AERD (Monitor 14; Hall A) -  Sep 29, 2024 - Abstract #ACAAI2024ACAAI_1115;    
    Introduction : Aspirin-exacerbated respiratory disease (AERD) is a condition characterized by the triad of asthma, nasal polyposis, and sensitivity to aspirin and other non-selective COX inhibitors...This case illustrates the potential efficacy of antifungals in patients with AERD and culture-proven airway mycosis who do not respond to first-line therapies. CT Sinuses Before and After Terbinafine Abstracts: Medically Challenging Case Abstracts / Ann Allergy Asthma Immunol 00 (2024) 1?110 99
  • ||||||||||  Dupixent (dupilumab) / Sanofi, Regeneron
    CASE REPORT: SUCCESSFUL REINTRODUCTION OF IBUPROFEN IN A PATIENT WITH NERD FOLLOWING TREATMENT WITH DUPILUMAB (Monitor 7; Hall A) -  Sep 29, 2024 - Abstract #ACAAI2024ACAAI_696;    
    Given that aspirin and ibuprofen have similar mechanisms of action, we hypothesized dupilumab could induce tolerance to ibuprofen and other selective and/or non-selective cyclooxygenase inhibitors. While the success of this case shows promising therapeutic potential, further investigation is required to evaluate the reproducibility and efficacy of dupilumab to induce ibuprofen tolerance on a larger scale.
  • ||||||||||  Tarlige (mirogabalin) / Daiichi Sankyo
    Preclinical, Journal:  Analgesic effects of co-administration of mirogabalin and diclofenac sodium on neuropathic pain in rats. (Pubmed Central) -  Sep 22, 2024   
    Diclofenac sodium inhibits cyclooxygenase-2 and prostaglandin production, related to allodynia. These effects of mirogabalin and diclofenac sodium, respectively, inhibited glia cells strongly, which is presumed to be one of the mechanisms for the effectiveness of their co-administration for neuropathic pain.
  • ||||||||||  Review, Journal, Adverse events:  Design, classification, and adverse effects of NSAIDs: A review on recent advancements. (Pubmed Central) -  Sep 11, 2024   
    The review also presents an integrated classification of NSAIDs incorporating both traditional chemical-based and function-based approaches, including a brief overview of the NSAIDs of natural origins. Additionally, the review addresses adverse effects associated with different NSAIDs, including effects associated with cardiovascular, renal, and hepatic complications emphasizing the need for the development of new and safer COX inhibitors.
  • ||||||||||  ketamine / Generic mfg., clozapine / Generic mfg.
    Biomarker, Journal:  Next-generation precision medicine for suicidality prevention. (Pubmed Central) -  Sep 7, 2024   
    Lastly, we compared that to machine learning approaches, to optimize predictive ability and identify key features. We propose that our findings and comprehensive approach can have transformative clinical utility.
  • ||||||||||  flurbiprofen / Generic mfg.
    Journal:  Sequential Targeted Enzyme-Instructed Self-Assembly Supramolecular Nanofibers to Attenuate Intervertebral Disc Degeneration. (Pubmed Central) -  Sep 2, 2024   
    In this study, drug-loaded nanofibers with sequential targeting functions are constructed through intelligent response, hydrophilicity, and in situ self-assembly empowerment of flurbiprofen...In vivo, drug-loaded nanofibers delay intervertebral disc degeneration by inhibiting inflammation and preventing the accumulation of senescent cells. Therefore, the sequentially targeted self-assembled drug-loaded nanofibers can delay intervertebral disc degeneration by blocking the synergistic effect of inflammatory cytokines and cellular senescence.
  • ||||||||||  Kineret (anakinra) / SOBI
    Journal:  Repeated seizure-induced brainstem neuroinflammation contributes to post-ictal ventilatory control dysfunction. (Pubmed Central) -  Aug 23, 2024   
    Therefore, the sequentially targeted self-assembled drug-loaded nanofibers can delay intervertebral disc degeneration by blocking the synergistic effect of inflammatory cytokines and cellular senescence. To further test the role of inflammation in physiological responses to seizures and seizure-related mortality, additional groups of SS kcnj16-/- rats were treated with anakinra (IL-1R antagonist), ketoprofen (non-selective COX inhibitor), or saline for 3
  • ||||||||||  Prostaglandins induce sleep through peripheral sleep-promoting mechanisms (MCP Hall A) -  Aug 22, 2024 - Abstract #Neuroscience2024Neuroscience_6511;    
    The results suggest that the sleep-inducing effects of PGE2 are mediated by a sensory mechanism located in the liver and/or in the portal vein wall. Hepatoportal prostaglandin-sensitive pathways likely contribute to sleep modulation by the intestinal microbiota.
  • ||||||||||  meloxicam / Generic mfg.
    NSAID-Induced Diaphragm Disease on Capsule Endoscopy: A Case Series (Exhibit Hall E) -  Aug 20, 2024 - Abstract #ACG2024ACG_5509;    
    Case 2: A 58 year-old woman with osteoarthritis on meloxicam 15 mg daily presented with acute cramping abdominal pain, nausea and vomiting...Figure: Figure 1. Circumferential ulcers with stricturing in the ileum captured on video capsule endoscopy in patient cases 1 (A, B) and 2 (C).
  • ||||||||||  Olumiant (baricitinib) / Eli Lilly
    Review, Journal:  Rheumatoid arthritis-recent advances in pathogenesis and the anti-inflammatory effect of plant-derived COX inhibitors. (Pubmed Central) -  Aug 17, 2024   
    This review lists various phytochemicals and discusses their potential molecular targets in RA treatment, as demonstrated by various in vitro, in vivo (pre-clinical), and clinical studies. Several pre-clinical and clinical studies suggest that various phytochemicals can be an alternative promising intervention for attenuating and managing inflammation-associated pathogenesis of rheumatoid arthritis.
  • ||||||||||  Journal:  Effects of Total Parenteral Nutrition on Serum Osmolality and Patent Ductus Arteriosus. (Pubmed Central) -  Aug 12, 2024   
    Thus, the prevention of hypernatremia might reduce the incidence of PDA. Nonetheless, the findings in this study revealed that no statistically significant differences in serum osmolality were observed between the pre-and post-TPN periods, indicating that TPN had little effect on serum osmolality.
  • ||||||||||  Journal, PD(L)-1 Biomarker, IO biomarker, Metastases:  PD-1 blockade plus COX inhibitors in dMMR metastatic colorectal cancer: Clinical, genomic, and immunologic analyses from the PCOX trial. (Pubmed Central) -  Aug 10, 2024   
    P2
    The clinical management of PDA in Japan featured (1) COX-I administration based on echocardiographic findings before symptomatic or hemodynamically significant PDA appeared and (2) frequent discontinuation of therapeutic COX-I before completing the standard three doses course. Thus, COX inhibitors combined with PD-1 blockade may be effective and safe treatment options for patients with dMMR metastatic colorectal cancer, and TAPBP may serve as a biomarker for immune checkpoint inhibitor therapy (this study was registered at ClinicalTrials.gov: NCT03638297).
  • ||||||||||  flurbiprofen / Generic mfg., ibuprofen / Generic mfg.
    Journal:  Anticancer potential of NSAID-derived tris(pyrazolyl)methane ligands in iron(II) sandwich complexes. (Pubmed Central) -  Jul 29, 2024   
    The ligands and complexes were investigated for their ability to inhibit COX-2 (cyclooxygenase) and HNE (4-hydroxynonenal) enzymes. Complexes 3 and 4 exhibited cytotoxicity that may be attributed predominantly to their bioactive fragments, while DNA binding and enhancement of ROS production do not appear to play any significant role.
  • ||||||||||  Preclinical, Journal:  Spontaneous vascular dysfunction in Dahl salt-sensitive male rats raised without a high-salt diet. (Pubmed Central) -  Jul 26, 2024   
    Despite showing some differences in their responses to various vasoactive substances, both SS/Jr rats and SHRs exhibited key features of vascular dysfunction, including endothelial dysfunction and hyperresponsiveness to vasocontractile agonists. In conclusion, this study provides evidence to support the utility of the SS/Jr rat strain maintained on a low-salt diet as a valid experimental model for vascular dysfunction, a key feature of human hypertension.
  • ||||||||||  RQ-00317076 (AAT-076) / RaQualia
    Discovery and Development of a Centrally Active, Structurally Unique COX-2 Inhibitor (Exhibition Hall/Poster Area) -  Jul 18, 2024 - Abstract #IASP2024IASP_2172;    
    AAT-076 is clinically validated, i.e., superior efficacy v. ibuprofen in terms of onset, potency, and duration of action, with a substantial safety database in clinical studies with ~800 subjects. AAT-076, with unique pharmacological properties, has the potential to offer patients an effective analgesic medication for acute and chronic pain conditions, and in so doing could help end the prescription opioid crisis.
  • ||||||||||  Review, Journal:  Chemoprevention of head and neck cancer: a review of current approaches and future perspectives. (Pubmed Central) -  Jul 9, 2024   
    The published results reaffirm the promise of chemoprevention in head and neck cancer and suggest that continued exploration is needed to overcome the limitations. Since the current focus on chemopreventive agents is limited, major efforts in precision oncology approaches and substantial increase in funding will promote research into chemoprevention which will eventually decrease the incidence of HNSCC.
  • ||||||||||  piroxicam / Generic mfg.
    P1 data, PK/PD data, Journal:  Exploring the pharmacokinetics and tolerability of cyclooxygenase inhibitor ampiroxicam: a phase I study on single and multiple oral doses. (Pubmed Central) -  Jul 8, 2024   
    Plasma levels of piroxicam, a key metabolite of ampiroxicam, were measured using ultra-performance liquid chromatography...No significant differences were noted across the dosage groups, and sex-specific differences were minimal, with the exception of mean residence time (MRT) in the multiple-dose group, which appeared influenced by body weight variations. The findings affirm the safety and efficacy of ampiroxicam across different dosing regimens, validating its clinical utility and potential for personalized medicine in the treatment of pain and inflammation.