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- | mirdametinib (PD-0325901) / SpringWorks Therap, BeiGene
Journal: EBV down-regulates COX-2 expression via TRAF2 and ERK signal pathway in EBV-associated gastric cancer. (Pubmed Central) - Jul 2, 2020
Furthermore, si-ERK1/2 and the MEK inhibitor PD0325901 were used to investigate whether p-ERK participate in the regulation of COX-2 in SGC7901...And the decrease of p-ERK also mediates the inhibitory effect of LMP1 on COX-2. In summary, overexpression of LMP1 and LMP2A inhibits COX-2, which is mediated by a decrease of TRAF2, and p-ERK is involved in the inhibition of COX-2 by LMP1 in gastric cancer.
- | indomethacin / PLx Pharma Inc, Generic mfg.
Journal: Crth2 receptor signaling down-regulates lipopolysaccharide-induced NF-κB activation in murine macrophages via changes in intracellular calcium. (Pubmed Central) - Jul 2, 2020
Targeting the endogenous biosynthetic pathway of CyPGs with indomethacin or HQL79, which inhibit cyclooxygenases or hematopoietic prostaglandin D synthase, respectively, or use of Crth2 antagonists recapitulated the proinflammatory phenotype as in Crth2 KO cells...Interestingly, Crth2 signaling down-regulated the Ca-regulated heat stable protein 1 that stabilizes Tnf-α mRNA via the increased expression of microRNA 155 to dampen inflammatory responses triggered through the TNF-α-NF-κB axis. In summary, these studies present a novel regulatory role for Crth2 during inflammatory response in macrophages.-Diwakar, B. T., Yoast, R., Nettleford, S., Qian, F., Lee, T.-J., Berry, S., Huffnagle, I., Rossi, R. M., Trebak, M., Paulson, R. F., Prabhu, K. S. Crth2 receptor signaling down-regulates lipopolysaccharide-induced NF-κB activation in murine macrophages via changes in intracellular calcium.
- [VIRTUAL] Non-steroidal anti-inflammatory drugs act as adjuvant in allergic sensitization () - Jul 1, 2020 - Abstract #SID2020SID_67;
NSAID-treated animals, regardless of sex or strain, produced high levels of OVA-specific IgE and IgG1 during sensitization, and anaphylaxed to OVA, but not NSAID, challenge. This suggests that the widespread use of NSAIDs may be a major contributor to the development of allergic disease and has broad implications for their judicious use as supportive therapy in a wide variety of common clinical settings.
- | Journal: Molecular insights into benzene sulphonamide substituted diarylpyrazoles as cyclooxygenase-2 inhibitor and its structural modifications. (Pubmed Central) - Jul 1, 2020
The study suggests crucial properties and key interactions that are essential for potent enzyme inhibition and finds this series as a promising lead for further development as novel cyclooxygenase agents. Communicated by Ramaswamy H. Sarma.
- | Journal: Profiling the interaction of 1-phenylbenzimidazoles to cyclooxygenases. (Pubmed Central) - Jun 26, 2020
While inhibitors produce different local structural changes at the COX ligand binding site, induced fit allows inhibitors in diverse chemical classes to share characteristic interaction patterns that ensure key contacts to be achieved. Different interaction patterns may also be associated with different inhibitory mechanisms.
- | aspirin / Generic mfg., celecoxib oral / Generic mfg.
Journal: Arg-513 and Leu-531 Are Key Residues Governing Time-Dependent Inhibition of Cyclooxygenase-2 by Aspirin and Celebrex. (Pubmed Central) - Jun 26, 2020
AA binds in a C-shaped pose, facilitated by the rotation of the Leu-531 side chain. Ile-349 is positioned to sterically shield antarafacial oxygen addition at carbon-15 in a manner similar to that proposed for the acetylated Ser-530 side chain.
- | Journal: Examining barbiturate scaffold for the synthesis of new agents with biological interest. (Pubmed Central) - Jun 25, 2020
Compound 8b was profiled as a drug-like candidate. The barbiturate core represents a new scaffold for lipoxygenases inhibition, and the undertaken derivatives show promise as multiple-target agents to combat inflammatory diseases.
- | sulindac / Generic mfg.
Journal: Radioprotective Potential of Sulindac Sulfide to Prevent DNA Damage Due to Ionizing Radiation. (Pubmed Central) - Jun 19, 2020
On the other hand, pretreatment at 250 μM of SS inhibited IR-induced oxidative stress, which led to a decrease in the MN frequencies and MDA levels, while SOD activity showed an increase in the exposed cells. It could be concluded that SS as a good radioprotective agent protects the human normal cells against the oxidative stress and genetic damage induced by IR.
- | aspirin / Generic mfg.
Review, Journal: Aspirin sensitivity: Lessons in the regulation (and dysregulation) of mast cell function. (Pubmed Central) - Jun 18, 2020
Recent studies in both human subjects and animal models have revealed a complex and multifactorial process culminating in dysregulation of MC function and an aberrant dependency on COX-1-derived prostaglandin E to maintain a tenuous homeostasis. This article reviews the factors most likely to contribute to MC dysregulation in patients with AERD and the potential diagnostic and therapeutic implications.
- | Journal: Mechanistic study on the use of the L-type amino acid transporter 1 for brain intracellular delivery of ketoprofen via prodrug: a novel approach supporting the development of prodrugs for intracellular targets. (Pubmed Central) - Jun 10, 2020
l-Type amino acid transporter 1 (LAT1), selectively expressed at the blood-brain barrier (BBB) and brain parenchymal cells, mediates brain delivery of drugs and prodrugs such as l-dopa and gabapentin...The overall efficiency of plasma to brain intracellular delivery of prodrug-released ketoprofen was 11 times higher than after ketoprofen dosing. In summary, this study provides quantitative information supporting the use of the LAT1-mediated prodrug approach for enhanced brain delivery of drugs with intracellular targets.
- ||| indomethacin / PLx Pharma Inc, Generic mfg.
Journal, Adverse events: Effects of antenatal indomethacin on ductus arteriosus early closure and on adverse outcomes in preterm neonates. (Pubmed Central) - Jun 8, 2020
This result, which has never been evidenced in previous studies, has great clinical importance. It is well known that PDA is more frequent at lower gestational ages, thus reducing the incidence of PDA could lead to an improvement of overall outcomes in extremely preterm newborns.
- | celecoxib oral / Generic mfg.
Journal: Celecoxib aggravates atherogenesis and upregulates leukotrienes in ApoE mice and lipopolysaccharide-stimulated RAW264.7 macrophages. (Pubmed Central) - Jun 8, 2020
It is well known that PDA is more frequent at lower gestational ages, thus reducing the incidence of PDA could lead to an improvement of overall outcomes in extremely preterm newborns. The COX-2-selective inhibitor celecoxib can aggravate atherogenesis, an effect that may be related to upregulation of LTs via a 5-LO pathway shunt.
- || indomethacin / PLx Pharma Inc, Generic mfg.
Clinical, Journal: Indomethacin attenuates mechanical allodynia during the organization but not the maintenance of the peripheral neuropathic pain induced by nervus ischiadicus chronic constriction injury. (Pubmed Central) - Jun 8, 2020
The data showed that indomethacin decreased the mechanical allodynia threshold of rats on the first, second, and fourth days after CCI (P<0.05). These findings suggested that inflammatory mechanisms are involved in the induction of NP and that COX-1 and COX-2 are involved in the induction but not in the maintenance of NP.
- | dalfampridine / Generic mfg.
Journal: K and K channels modulate the venoarteriolar reflex in non-glabrous human skin with no roles of K channels, NOS, and COX. (Pubmed Central) - Jun 4, 2020
The venoarteriolar reflex was assessed at the following forearm skin sites: Experiment 1 (n = 11): 1) lactated Ringer solution (Control), 2) 10 mM N-nitro--arginine (NOS inhibitor), 3) 10 mM ketorolac (COX inhibitor), and 4) combined NOS + COX inhibition; Experiment 2 (n = 15): 1) lactated Ringer solution (Control), 2) 50 mM tetraethylammonium (K channel blocker), 3) 5 mM glybenclamide (K channel blocker), and 4) 10 mM 4-aminopyridine (K channel blocker)...We showed that K and K channels modulate the venoarteriolar reflex with minimum roles of NOS, COX, and K channels in human non-glabrous forearm skin in vivo. Thus, cutaneous venoarteriolar reflex changes could reflect altered K channel function.
- | Biomarker, Preclinical, Journal: Coffee, but Neither Decaffeinated Coffee nor Caffeine, Elicits Chemoprotection Against a Direct Carcinogen in the Colon of Wistar Rats. (Pubmed Central) - May 31, 2020
Both decaffeinated coffee and caffeine decreased hepatic α-tocopherol levels. We suggest that coffee may have other compounds that elicit greater chemoprotective effects than caffeine reducing the CRC risk.
- || meloxicam / Generic mfg., celecoxib oral / Generic mfg.
PK/PD data, Preclinical, Journal: Development of an in Vivo Lipopolysaccharide Inflammation Model to Study the Pharmacodynamics of COX-2 Inhibitors Celecoxib, Mavacoxib, and Meloxicam in Cockatiels (Nymphicus hollandicus). (Pubmed Central) - May 31, 2020
All three NSAIDs were able to inhibit the increase in LPS-induced PGE2 plasma concentrations, yet the effect was most pronounced in the birds treated with meloxicam. Consequently, the presented model opens perspectives for future dose-effect PD studies to optimize analgesic protocols in cockatiels.
- | glibenclamide / Generic mfg.
Journal: Propofol-Induced Vasodilation in Human Internal Mammary Artery: Role of Potassium Channels. (Pubmed Central) - May 27, 2020
This study clearly reveals that propofol relaxes the IMA, and propofol-induced vasodilation may be related to large conductance calcium ion-activated potassium ion channel activation. Propofol use in coronary artery bypass surgery can be valuable via its favorable vasodilator effect to overcome perioperative vasospasm of IMA.
- ||| indomethacin / PLx Pharma Inc, Generic mfg.
Tociluzumab is a specific IL 6 Monoclonal ab inhibitor. Indomethacin is a non specific Cyclooxygenase inhibitor with significant Gastric, renal toxicity. (Twitter) - May 27, 2020
- | Preclinical, Journal: Brain Prostaglandin D2 Increases Neurogenic Pressor Activity and Mean Arterial Pressure in Angiotensin II-Salt Hypertensive Rats. (Pubmed Central) - May 25, 2020
Blockade of DP1R with BWA868C, however, increased the magnitude of Ang II-salt hypertension and significantly increased neurogenic pressor activity. In summary, we establish that the development of Ang II-salt hypertension requires increased COX- and L-PGDS-derived PGD2 production in the brain, making L-PGDS a possible target for treating neurogenic hypertension.
- || fluorouracil / Generic mfg.
Clinical, Journal: Management of Non-melanoma Skin Cancer in Transplant Recipients. (Pubmed Central) - May 23, 2020
Adjusting the immunosuppressive regimen is also an important adjuvant therapeutic strategy for managing skin cancers in transplant recipients and requires integrated multidisciplinary care with the entire transplant team. This article reviews the epidemiology of non-melanoma skin cancer in transplant patients, discusses the prevention strategies and highlights the management and treatment strategies of both field cancerisation and non-melanoma skin cancers.
- | Preclinical, Journal: Lipidomes of brain from rats acutely intoxicated with diisopropylfluorophosphate identifies potential therapeutic targets. (Pubmed Central) - May 23, 2020
Following acute DFP intoxication, most of the pro-inflammatory lipid mediators (e.g., PGD2 and PGE2) increased rapidly from day 1, while the concentrations of some anti-inflammatory lipid mediators (e.g. 14,15 EpETrE) decreased after DFP intoxication but recovered by day 14 post-exposure. The lipidomics results suggest two potential treatment targets: blocking the formation of prostaglandins by inhibiting COX and stabilizing the anti-inflammatory lipid mediators containing epoxides by inhibiting the enzyme soluble epoxide hydrolase (sEH).
- || aspirin / Generic mfg.
Review, Journal: Effects of Antiplatelet and Nonsteroidal Anti-inflammatory Medications on Platelet-Rich Plasma: A Systematic Review. (Pubmed Central) - May 20, 2020
Search terms consisted of 1 item selected from "platelet-rich plasma," "platelet-derived growth factor," and "platelet-rich plasma AND growth factor" combined with 1 item from "antiplatelet," "aspirin," "anticoagulant," and "NSAID." Only studies published within the past 25 years were included...Eight of 15 studies found a decrease in growth factors or mitogenesis. However, more studies are needed to comprehensively understand antiplatelet effects on the PRP secretome.
- naproxen ER / Generic mfg., ibuprofen / Generic mfg., naproxen / Generic mfg.
[VIRTUAL] Fixed exanthema to naproxen with tolerance to ibuprofen and dexketoprofen () - May 19, 2020 - Abstract #EAACI2020EAACI_1582;
However, more studies are needed to comprehensively understand antiplatelet effects on the PRP secretome. We have demonstrated a fixed exanthema due with selective reactivity to an NSAID derived from arylpropionic acid (naproxen) with tolerance to other NSAIDs in the same group (ibuprofen and dexketoprofen).
- [VIRTUAL] Allergy to lysine clonixinate with positive prick test () - May 19, 2020 - Abstract #EAACI2020EAACI_1577;
Cross-reactivity between drugs of the nicotinic group could not be demonstrated as authorization by patient therefore could not be obtained. Prick test to LC is a useful tool for the diagnosis of immediate acute urticaria allergy due to sensitization to LC.
- aspirin / Generic mfg.
[VIRTUAL] Oral aspirin provocation test and clinical characteristics of patients with chronic rhinosinusitis, nasal polyps and asthma () - May 19, 2020 - Abstract #EAACI2020EAACI_1223;
Therefore, we reinforce EAACI's Position Paper on the need for PT with ASA in all patients with CRS, even in the absence of a history of reaction to NSAIDs. Patients with AERD seem to be more atopic and have more severe asthma.
- | Journal: Isoalantolactone inhibits IKKβ kinase activity to interrupt the NF-κB/COX-2-mediated signaling cascade and induces apoptosis regulated by the mitochondrial translocation of cofilin in glioblastoma. (Pubmed Central) - May 17, 2020
In conclusion, the current study indicated that IATL inhibited the expression of COX-2 through the NF-κB signaling pathway and induced the apoptosis of glioma cells by increasing actin transformation. These results suggested that IATL could be greatly effective in GBM treatment.
- Inhibition of nitric oxide synthase and cyclooxygenase potentiate immune responses that control aggressive mammary tumor in a murine model (Virtual Meeting II: E-Posters) - May 16, 2020 - Abstract #AACRII2020AACR-II_4517;
COX inhibition can treat aggressive TNBC directly by reducing cancer cell proliferation and indirectly by immune activation. Tandem NOS2 inhibition can render the pulmonary microenvironment unfavorable for metastatic spread and induce a favorable systemic cytokine storm that further improves outcome.
- nalbuphine / Endo
[VIRTUAL] The Effect of Postoperative Analgesia on the Hemostatic System in Gerontological Patients with Multiple Trauma (Virtual Meeting Room 6) - May 14, 2020 - Abstract #ISTH2020ISTH_2312;
Conclusions. The use of a combination of COX-2 and COX-3 inhibitors for postoperative analgesia in gerontological patients with polytrauma has a positive effect on the hemostatic system: the concentration of RFMC is significantly reduced and the concentration of AT-III is significantly increased.
- | Journal: A crystallographic and theoretical study of an (E)-2-Hydroxyiminoethanone derivative: prediction of cyclooxygenase inhibition selectivity of stilbenoids by MM-PBSA and the role of atomic charge. (Pubmed Central) - May 13, 2020
The binding conformation of the hydroxyiminoethanone derivative is highly correlated with the type of COX isoform inhibited. Our predictive approach can truly predict the cyclooxygenase inhibition selectivity of stilbenoid inhibitors.
- | ibuprofen / Generic mfg.
Biomarker, Journal: Variability in the Analgesic Response to Ibuprofen is Associated with Cyclooxygenase Activation in Inflammatory Pain. (Pubmed Central) - May 13, 2020
Differentially expressed genes in peripheral blood mononuclear cells were enriched for inflammation-related pathways. These findings suggest that a less pronounced activation of the inflammatory prostanoid system is associated with insufficient pain relief on ibuprofen alone and the need for additional therapeutic intervention.
- | indomethacin / PLx Pharma Inc, Generic mfg.
Journal: Differential contribution of cyclooxygenase to basal cerebral blood flow and hypoxic cerebral vasodilation. (Pubmed Central) - May 13, 2020
Hypoxia (SO 80-83%) increased CVC (p<0.01), reflected as a similar relative increase in reactivity (%DCVC/ DSO) across arteries (p<0.05), due in part to increases in CSA (p<0.05). Indomethacin did not alter DCVC or DCVC/DSO to hypoxia.These findings indicate: 1) COX contributes, in a largely uniform fashion, to cerebrovascular tone during normoxia, and 2) COX is not obligatory for hypoxic vasodilation in any regions supplied by large extracranial or intracranial arteries.
- | Preclinical, Journal: Dietary supplementation with procyanidin-rich Pinus pinaster extract is associated with attenuated Ehrlich tumor development in mice. (Pubmed Central) - May 11, 2020
Only Pyc significantly inhibited COX-2. Pyc attenuated oxidative and inflammation mediators and impaired tumor development, supporting our hypothesis and suggesting Pyc as a candidate for future studies in multitargeted dietary-based cancer prevention approaches.
- | oxaliplatin / Generic mfg., cisplatin / Generic mfg.
Journal: Development of a series of 4-hydroxycoumarin platinum(IV) hybrids as antitumor agents: Synthesis, biological evaluation and action mechanism investigation. (Pubmed Central) - May 9, 2020
Furthermore, the conversion of platinum(II) drugs to platinum(IV) form via the conjunction with 4-hydroxycoumarin enhances the drug uptake in whole cells and DNA simultaneously. Moreover, the 4-hydroxycoumarin platinum(IV) complex could combine with human serum albumin via van der Waals force and hydrogen bond, which would influence their transport and bioactivities in vivo.
- | celecoxib oral / Generic mfg.
Journal: c-Met inhibition is required for the celecoxib-attenuated stemness property of human colorectal cancer cells. (Pubmed Central) - May 7, 2020
Silence of c-Met blocked whereas overexpression of c-Met enhanced the celecoxib-inhibited CSC property. Collectively, these results not only first elucidate the mechanism underlying celecoxib-inhibited CSC but also indicate c-Met as a critical factor for the CSC property of CRC cells.
- | Clinical, Review, Journal: Maintenance tocolysis: a reappraisal of clinical evidence. (Pubmed Central) - May 7, 2020
Basically, the value of studies regarding maintenance tocolysis is limited by a considerable heterogeneity, its mostly low quality, significant differences in methodology as well as the inadequate statistical power due to the small number of women studied. So far, maintenance tocolysis is a case-by-case decision outweighing the benefits and harms of tocolytic treatment.
- | indomethacin / PLx Pharma Inc, Generic mfg.
Preclinical, Journal: Multiple In vitro biological effects of phenolic compounds from Morus alba root bark. (Pubmed Central) - May 7, 2020
So far, maintenance tocolysis is a case-by-case decision outweighing the benefits and harms of tocolytic treatment. Experimental investigation showed promising antiviral, antibacterial, and/or anti-inflammatory activities of the phenolic mulberry constituents, often with multiple inhibitory effects that might be used as a potential source of new medicine.
- | nitroprusside / Generic mfg.
Journal: Prostanoids contribute to regulation of inwardly rectifying K channels in intrarenal arterial smooth muscle cells. (Pubmed Central) - May 6, 2020
The present results reveal that vasoconstrictor stimulation augments RIRA contraction induced by Kir closure with Ba and indicate that prostanoid synthesis followed by TPR activation is involved in the modulation of the myocyte Kir activity. This study suggests that prostanoid synthesis and TPR may be potential targets for dysfunctions in renal blood circulation.
- | Preclinical, Journal: RP-HPLC estimation of flavonol derivatives and phenolic acids in Capsicum annuum L. and their correlation with in vitro anti-inflammatory activity. (Pubmed Central) - May 2, 2020
Therefore, the role of FD and PA has been postulated to be an active phytochemical of CA accountable for its anti-inflammatory activity. However further work is desirable to fully elucidate the phytochemicals responsible for their anti-inflammatory activity and to develop better herbal drug formulations.
- Rebif (human IFN-β-1a) / EMD Serono
[VIRTUAL] Cyclooxygenase inhibitor use during checkpoint immunotherapy and effect on time to progression and overall survival for metastatic melanoma and non-small cell lung cancer patients. () - Apr 29, 2020 - Abstract #ASCO2020ASCO_5723;
NSCLC patients using COXi had prolonged OS. Furthermore, COXi use appears to reverse the negative prognostic effect of a high NLR by prolonging TTP in melanoma patients.
- | cyclophosphamide intravenous / Generic mfg.
Preclinical, Journal: Hypoactivity of rat detrusor muscle in a model of cystitis: exacerbation by non-selective COX inhibitors and amelioration by a selective DP receptor antagonist. (Pubmed Central) - Apr 27, 2020
This study aims to compare the potential effects of some COX inhibitors with varying COX-1/COX-2 selectivities (indomethacin, ketoprofen, and diclofenac) with that of the selective COX-2 inhibitor (DFU) on bladder function...A model of hemorrhagic cystitis was induced by single injection of cyclophosphamide (300 mg/kg) in rats, and confirmed by histophathological examination...DP receptors as COX-2, on the other hand, gain an important role only in case of cystitis. The use of non-selective COX inhibitors in cystitis may be associated with bladder hypoactivity; selective COX-2 inhibitors may be a safer option.
- || Clinical, Journal: A case of acute kidney injury secondary to black cherry concentrate in a patient with chronic kidney disease secondary to type 2 diabetes mellitus. (Pubmed Central) - Apr 26, 2020
Patient's kidney injury and metabolic disturbances improved after the discontinuation of black cherry concentrate. This is the second case report that presents a correlation between consumption of cherry concentrate in a patient with chronic kidney disease and acute kidney injury.
- | Journal: Effect of Novel Pyrrolo[3,4-d]pyridazinone Derivatives on Lipopolysaccharide-Induced Neuroinflammation. (Pubmed Central) - Apr 26, 2020
The compounds improved neuronal features, such as neurite length and outgrowth, and they also increased cell viability and mitochondrial activity. Our results suggest that derivatives 2a and 2b may also act additionally on mechanisms other than 3a and 3b.
- indomethacin / PLx Pharma Inc, Generic mfg.
COX inhibition enhances allergen-induced IL-33 release and ILC2 responses in mouse lungs (Board Number: P451) - Apr 25, 2020 - Abstract #IMMUNOLOGY2020IMMUNOLOGY_243;
Indomethacin also increased reactive oxygen species (ROS) production in the lung, providing a possible mechanism for the increased IL-33 release. Although contrasting effects of PGD2 and PGE2/PGI2 on ILC2 responses have been previously reported, the overall effect of COX pathway on ILC2 function is inhibitory in Alternaria extract-induced airway innate type 2 responses.
- ||| indomethacin / PLx Pharma Inc, Generic mfg., ibuprofen / Generic mfg.
Putting all three under cyclooxygenase inhibitors... Although acetaminophen is not an Nsaid it poses the a selective cox2 inhibition properties making it similar to the indomethacin and ibuprofen (Twitter) - Apr 22, 2020
- || I would go for COX inhibitors ( non specific ). Acetaminophen is documented to have COX-2 inhibition effect . Or prostaglandin generation inhibitors ( pcm acts mainly on the POX site if I recall correctly ) (Twitter) - Apr 22, 2020
- | Journal: Endothelial prostacyclin protects the kidney from ischemia-reperfusion injury. (Pubmed Central) - Apr 17, 2020
Folic acid also induced marked kidney injury; however, endothelial PGIS deletion did not worsen kidney injury compared with wild-type mice. These studies indicate that PGIS-derived PGI can protect the kidney from acute injury caused by ischemia and reperfusion and PGIS/PGI is a potential intervention target for AKI.
- The Microbiome-Immune-Brain Axis and Cognitive Side Effects of Electroconvulsive Therapy (Americas Hall I & II) - Apr 17, 2020 - Abstract #SOBP2020SOBP_1584;
This connection suggests the possibility of the microbiome affecting inflammatory pathways related to the cognitive side effects of ECT. Nonetheless, further work is needed to evaluate the neurobiological underpinnings of ECT-induced cognitive side effects as facilitated by neuroinflammatory pathways and changes in the microbiome.
- | celecoxib oral / Generic mfg.
Journal: Anti-inflammatory drug approach: Synthesis and biological evaluation of novel pyrazolo[3,4-d]pyrimidine compounds. (Pubmed Central) - Apr 14, 2020
Our best hit, 4d (COX-1 IC of 28 µM, COX-2 IC of 23 µM), appears to adopt similar binding modes to the standard COX-2 inhibitor, celecoxib, proposing room for possible selectivity...Interestingly, they showed greater potency than the famous non-steroidal anti-inflammatory drug, Diclofenac sodium. In summary, these novel pyrazolo[3,4-d]pyrimidine analogues showed interesting anti-inflammatory activity and could act as a starting point for future drugs.
- | Journal: Anti-Amyloidogenic and Cyclooxygenase Inhibitory Activity of Guettarda speciosa. (Pubmed Central) - Apr 14, 2020
The putative compounds from the LC-MS analysis could be responsible for the observed activities. The results suggest that G. speciosa possesses anti-inflammatory and anti-neurodegenerative properties and a promising lead as a source of pharmacologically active compounds.
- celecoxib oral / Generic mfg.
[VIRTUAL] A phase 1b, multicenter, randomized, blinded, placebo-controlled study to evaluate the efficacy of guselkumab in subjects with familial adenomatous polyposis (Virtual Meeting: All Session Times Are U.S. EDT) - Apr 13, 2020 - Abstract #AACRI2020AACR-I_417;
P1b
Multiple studies with both nonselective and selective cyclooxygenase inhibitors (such as sulindac or celecoxib) have shown that anti-inflammatory agents may prevent the formation and inhibit the growth of colorectal adenomatous polyps...As of January 2019, 18% of the planned 72 subjects have been enrolled. ClinicalTrials.gov Identifier: NCT03649971.