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78 Companies | 115 Products |
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115 Products | |
266 Diseases | |
841 Trials |  |
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- | celecoxib oral / Generic mfg.
Journal: Selective cyclooxygenase inhibition and ulcerogenic liability of some newly prepared anti-inflammatory agents having thiazolo[4,5-d]pyrimidine scaffold. (Pubmed Central) - Sep 24, 2020
The in vivo potent compounds (9e, 9g and 9k) caused variable ulceration effect (ulcer index = 5-12.25) in comparison to that of celecoxib (ulcer index = 3). Molecular docking was performed to the most potent COX-2 inhibitors (9e, 9g and 9k) to explore the binding mode of these derivatives with Cyclooxygenase-2 enzyme.
- | Journal: Molecular docking and experimental investigation of new indole derivative cyclooxygenase inhibitor to probe its binding mechanism with bovine serum albumin. (Pubmed Central) - Sep 24, 2020
Molecular docking and the experimental results corroborated one another. The study can prove as an insight for future IND drug development.
- | Journal: COX-1/COX-2 inhibition activities and molecular docking study of newly designed and synthesized pyrrolo[3,4-c]pyrrole Mannich bases. (Pubmed Central) - Sep 24, 2020
In order to analyse the intermolecular interactions between theligands and cyclooxygenase, experimental data were supported with the results of molecular docking simulations. According to the results, all of the tested compounds inhibited the activity of COX-1 and COX-2.
- | indomethacin / PLx Pharma Inc, Generic mfg.
Journal: The TNF-derived TIP peptide activates the epithelial sodium channel and ameliorates experimental nephrotoxic serum nephritis. (Pubmed Central) - Sep 23, 2020
The protective effect was blocked by the cyclooxygenase inhibitor indomethacin, indicating involvement of prostaglandins...In the later autologous phase of NTN, TIP peptide blunted the infiltration of Th17 cells. By countering the deleterious effects of TNF through direct actions in GEC, TIP peptide could provide a novel strategy to treat glomerular inflammation.
- | Journal: Isolation, characterization and anti-inflammatory mechanism of probiotics in lipopolysaccharide-stimulated RAW 264.7 macrophages. (Pubmed Central) - Sep 23, 2020
Further, these selected LAB isolates reduced the level of pro-inflammatory cytokines, TNF-α, IL-1β and IL-6, inhibited the phosphorylation of Mitogen Activated Protein Kinases (MAPKs) i.e. p38 MAPK, ERK1/2 and SAPK/JNK and expression of cyclooxygenase-2 (COX-2) in LPS stimulated RAW 264.7 cells. The in vitro analysis suggested that the selected probiotic isolates attenuated the LPS-induced inflammation by downregulating MAPK pathway vis-a-vis inhibiting COX-2 and can be employed as anti-inflammatory agents in various inflammatory diseases.
- | celecoxib oral / Generic mfg.
Journal: Ferulic Acid Prevents Angiogenesis Through Cyclooxygenase-2 and Vascular Endothelial Growth Factor in the Chick Embryo Chorioallantoic Membrane Model. (Pubmed Central) - Sep 20, 2020
Celecoxib (60 μg) was used as the reference drug...Reductions in VEGF-2 and COX-2 expression due to treatment with FA at the dose range 30-90 μg appeared to be related to angiogenesis inhibition, which was shown by two parameters, namely inhibition of neovascularization and endothelial cell growth in blood vessels. It was concluded that FA is a promising antiangiogenic therapeutic agent especially at the early stage, and this activity can arise from inhibitory action on COX-2 and VEGF-2 proteins.
- | Journal: Design, synthesis and biological evaluation of novel benzodioxole derivatives as COX inhibitors and cytotoxic agents. (Pubmed Central) - Sep 20, 2020
This was tenfold more than its IC values of 2.36 and 2.73 µM against COX1 and COX2, respectively. In general, the synthesized library has moderate activity against both enzymes (i.e., COX1 and COX2) and ortho halogenated compounds were more potent than the meta ones.
- | Journal: (±) Gancochlearols A and B: cytotoxic and COX-2 inhibitory meroterpenoids from Ganoderma cochlear. (Pubmed Central) - Sep 13, 2020
Their structures were identified by spectroscopic methods. Biological assessments show that the enantiomers of 1 and 2 are cytotoxic against three human cancer cell lines (A549, K562, Huh-7) and could inhibit COX-2 expression with IC values less than 10 μM.
- | Journal: Cyclooxygenase-2 inhibitor rofecoxib prevents chondrocytes against hypertrophy via Wnt/β-catenin pathway. (Pubmed Central) - Sep 12, 2020
Furthermore, Rofecoxib suppressed Axin2, β-catenin, and GSK3β expression of the Wnt pathway, which was activated by IL-1β or human recombinant Wnt-1 protein treatment. Therefore, Rofecoxib is an effective COX-2 inhibitor that protects CHs from hypertrophy by suppression of the Wnt/β-catenin pathway.
- | indomethacin / PLx Pharma Inc, Generic mfg., Miostat (carbachol) / Novartis
Journal: Insight into the Mechanisms Underlying the Tracheorelaxant Properties of the Sideritis raeseri Extract. (Pubmed Central) - Sep 12, 2020
These data suggest that the tracheorelaxant effect of the SRE is mediated at least partly by NO/cyclic guanosine monophosphate and cyclooxygenase-1-prostaglandin E2-dependent signaling. These findings indicate that the SRE may be used in various respiratory disorders.
- | Journal: Contribution of prostaglandins to exercise hyperaemia: Workload, ethnicity and sex matter! (Pubmed Central) - Sep 10, 2020
At the same relative force, these mechanical effects are greater in young men than young women, both in those of White European (WE) and Black African (BA) ethnicity. However, the dilator effects of PGs are deficient in BA women implying endothelial dysfunction.
- | indomethacin / PLx Pharma Inc, Generic mfg.
Preclinical, Journal: Bothrops leucurus venom induces acute hypotension in rats by means of its phospholipase A (blD-PLA). (Pubmed Central) - Sep 10, 2020
These effects were partially counteracted by pre-treatment with indomethacin (cyclooxygenase inhibitor)...Taken together, our results show that, at low doses, the venom of B. leucurus induces transient, acute hypotension in anesthetized rats following systemic vasodilation in a dose-dependent way. In addition, we provide clear evidence of the involvement of the enzymatic activity of blD-PLA in this cardiovascular response, acting via the production of vasodilating prostanoids.
- | Journal: Inhibition of PI3K-AKT Signaling Blocks PGE-Induced COX-2 Expression in Lung Adenocarcinoma. (Pubmed Central) - Sep 10, 2020
Simultaneous targeting of COX-2 and PI3K-AKT effectively suppressed PGE-induced cell proliferation and migration and both acted in a synergistic manner. Targeting the COX-2-PGE positive feedback loop may be therapeutically beneficial to lung adenocarcinoma.
- | Review, Journal: Free radical-dependent inhibition of prostaglandin endoperoxide H Synthase-2 by nitro-arachidonic acid. (Pubmed Central) - Sep 8, 2020
This literature revision as well as the results presented here strongly suggest a free radical-dependent inhibitory mechanism of PGHS-2 by NOAA. This is of relevance towards understanding the underlying mechanism of inhibition of PGHS by NOAA and its anti-inflammatory potential.
- | Preclinical, Journal: Cyclooxygenase inhibition in mice heightens adaptive- and innate-type responses against inhaled protease allergen and IL-33. (Pubmed Central) - Sep 5, 2020
This is of relevance towards understanding the underlying mechanism of inhibition of PGHS by NOAA and its anti-inflammatory potential. No abstract available
- | indomethacin / PLx Pharma Inc, Generic mfg.
Journal: Novel Series of Methyl 3-(Substituted Benzoyl)-7-Substituted-2-Phenylindolizine-1-Carboxylates as Promising Anti-Inflammatory Agents: Molecular Modeling Studies. (Pubmed Central) - Sep 4, 2020
Compound 4e was identified as the most active compound of the series with an IC of 6.71 M, which is comparable to the IC of indomethacin, a marketed non-steroidal anti-inflammatory drug (NSAID)...The pharmacokinetic properties and potential toxic effects were predicted for all the synthesized compounds, which indicated good drug-like properties. Thus, these synthesized compounds can be considered as potential lead compounds for developing effective anti-inflammatory therapeutic agents.
- | indomethacin / PLx Pharma Inc, Generic mfg.
Preclinical, Journal: Targeting cyclooxygenase by indomethacin decelerates progression of acute lymphoblastic leukemia in a xenograft model. (Pubmed Central) - Sep 2, 2020
The progression was monitored by noninvasive in vivo imaging of the engrafted leukemic cells, as well as by analyses of CD19+CD10+ leukemic blasts present in spleen or bone marrow at the termination of the experiments. The indomethacin treatment increased the level of p53 in the leukemic cells, implying that COX inhibition might reduce progression of ALL by attenuating protective paracrine PGE2 signaling from bone marrow stroma to leukemic cells.
- || celecoxib oral / Generic mfg.
Clinical, Journal: Anti-inflammatory compound shows therapeutic safety and efficacy against flavivirus infection. (Pubmed Central) - Sep 1, 2020
Furthermore, administering 5 mg/kg compound 2d to DENV-2-infected AG129 mice prolonged survival and reduced viremia and serum cytokine levels. Overall, compound 2d showed therapeutic safety and efficacy in vitro and in vivo and could be further developed as a potential therapeutic agent for flavivirus infection.
- | indomethacin / PLx Pharma Inc, Generic mfg.
Journal: Gastroprotective effect of the alkaloid boldine: Involvement of non-protein sulfhydryl groups, prostanoids and reduction on oxidative stress. (Pubmed Central) - Sep 1, 2020
The gastroprotective effect of Boldine was evaluated on gastric ulcer induced by 60% ethanol/0.3 M HCl or indomethacin (100 mg/kg) in mice...Moreover, the alkaloid reduced oxidative stress and inflammatory mediators in ethanol-ulcerated tissue, beyond has increased mucin-like glycoprotein amount. Finally, Boldine effect is dependent on non-protein sulfhydryl groups and prostanoids but does not involve the inhibition of H+/K + -ATPase activity, being a promising natural resource for gastric ulcer treatment.
- [VIRTUAL] Platelets Drive Anti-tumor Immunity in Non-alcoholic Fatty Liver Disease Associated Hepatocellular Carcinoma (Virtual Meeting Room 2) - Sep 1, 2020 - Abstract #SSO2020SSO_49;
Specifically, P2Y12 mediated platelet activation appears to be essential to optimal immune surveillance in NAFLD. P2Y12 PRI usage is high in NAFLD patients and therefore careful selection of anti-platelet agents may be warranted when caring for NAFLD and NAFLD-HCC patients.
- | Journal: Beta-ionone-inhibited proliferation of breast cancer cells by inhibited COX-2 activity. (Pubmed Central) - Aug 30, 2020
In addition, BI also significantly decreased the expression of COX-2 protein in rat mammary tumor tissues. Therefore, our findings indicate that BI possesses inhibitory proliferation of breast cancer cells through down-regulation of COX-2 activity.
- | Preclinical, Journal: Extracts from Cephalaria Uralensis (Murray) Roem. & Schult. and Cephalaria Gigantea (Ledeb.) Bobrov as Potential Agents for Treatment of Acne Vulgaris: Chemical Characterization and In Vitro Biological Evaluation. (Pubmed Central) - Aug 30, 2020
Taking into account the value of calculated therapeutic index (>10), it is worth noting that CUE can be subjected to in vivo study. Thus, CUE constitutes a very promising antiacne agent.
- | clopidogrel / Generic mfg.
Preclinical, Journal: Disorders on cardiovascular parameters in rats and in human blood cells caused by Lachesis acrochorda snake venom. (Pubmed Central) - Aug 29, 2020
Acetylsalicylic acid (ASA, a cyclooxygenase inhibitor) or clopidogrel (an ADP receptor blocker) inhibited the aggregating effect of SVLa...Altogether, under experimental conditions, SVLa induced blood coagulation, platelet aggregation, hypotension and bradycardia. Part of the effects presented here may be explained by the presence of snake venom metalloproteinases (SVMPs) and snake venom serine proteases (SVSPs), constituents of SVLa.
- | Journal: Exploring Biological Activity of 4-Oxo-4H-furo[2,3-h]chromene Derivatives as Potential Multi-Target-Directed Ligands Inhibiting Cholinesterases, β-Secretase, Cyclooxygenase-2, and Lipoxygenase-5/15. (Pubmed Central) - Aug 19, 2020
The two compounds were found to moderately inhibit COX-2 and lipoxygenases (LOX-5 and LOX-15). Compounds 3b and 3e were also evaluated for cytotoxicity against the breast cancer MCF-7 cell line and Hek293-T cells.
- | celecoxib oral / Generic mfg.
Preclinical, Journal: Arylidene analogues as selective COX-2 inhibitors: synthesis, characterization, in silico and in vitro studies. (Pubmed Central) - Aug 17, 2020
Molecular docking was carried out on COX-2 structures, which revealed that NDP-4011 to NDP-4016 targets allosteric binding site similar to the binding mode of the selective COX inhibitor Celecoxib. Furthermore, results of in vitro COX-2 inhibition assay supports arylidene analogues as COX-2 inhibitors.
- | ibuprofen / Generic mfg.
Journal: Interplay between inflammation and neural plasticity: both immune activation and suppression impair LTP and BDNF expression. (Pubmed Central) - Aug 15, 2020
We tested this hypothesis experimentally, by acute treatment of C57BL/6 adult male mice with different doses of two inflammatory modulators: lipopolysaccharide (LPS), an endotoxin, and ibuprofen (IBU), a nonselective cyclooxygenase inhibitor, which are respectively a pro- and an anti-inflammatory agent...Such effect appears to be dose-dependent since only the higher, but not the lower, dose of both compounds led to a plasticity impairment. Overall, the present findings indicate that acute treatment with pro- and anti-inflammatory agents impair neural plasticity in a dose dependent manner.
- [VIRTUAL] Cyclooxygenase inhibition in mice heightens adaptive- and innate-type responses against inhaled protease allergen and IL-33 () - Aug 14, 2020 - Abstract #WAC2020WAC_410;
Overall, the present findings indicate that acute treatment with pro- and anti-inflammatory agents impair neural plasticity in a dose dependent manner. The password to see abstracts was announced to registrants by email.
- | Journal, IO Biomarker: Rheumatoid arthritis synovial fibroblasts promote TREM-1 expression in monocytes via COX-2/PGE pathway. (Pubmed Central) - Aug 11, 2020
The password to see abstracts was announced to registrants by email. Our data is the first report to reveal the critical role of RASF in upregulating TREM-1 expression in monocytes, which indicates that TREM-1 might be a novel target for RA therapy.
- | Journal: (+/-)-Lucidumone, a COX-2 Inhibitory Caged Fungal Meroterpenoid from Ganoderma lucidum. (Pubmed Central) - Aug 11, 2020
A plausible biosynthetic pathway for 1 is proposed. A chemical biology approach reveals that (-)-1 selectively inhibits COX-2 by directly binding with an amino acid residue of Tyr385, representing a new structure scaffold of COX-2 inhibitors.
- || indomethacin / PLx Pharma Inc, Generic mfg.
Clinical, Journal: Reactive oxygen species and cyclooxygenase products explain the majority of hypoxic cerebral vasodilation in healthy humans. (Pubmed Central) - Aug 7, 2020
Current data indicate reactive oxygen species and cyclooxygenase together may account for the majority of the increase in cerebral blood flow through the middle cerebral artery during hypoxia. These data are the first to demonstrate compensatory hypoxic vasodilatory signaling in human cerebral circulation.
- | dexamethasone / Generic mfg.
Journal: Anti-Inflammatory Polymeric Nanoparticles Based on Ketoprofen and Dexamethasone. (Pubmed Central) - Aug 6, 2020
The RT-qPCR analysis shows that the ketoprofen nanoparticles were able to reduce to almost basal levels the expression of tested pro-inflammatory markers and increase the gene expression of anti-inflammatory cytokines under inflammatory conditions. However, the synergistic inhibition of Il12b observed in nanoparticles that combine dexamethasone and naproxen was not observed in nanoparticles that combine dexamethasone and ketoprofen, suggesting that the synergistic trans-repression of Il12b observed in the first case was not mediated by cyclooxygenase-dependent pathways.
- | Journal: Carboxyamidotriazole exerts anti-inflammatory activity in lipopolysaccharide-induced RAW264.7 macrophages by inhibiting NF-κB and MAPKs pathways. (Pubmed Central) - Aug 4, 2020
The results in the present study indicate that CAI alleviates the inflammatory responses of RAW 264.7 macrophages in response to LPS stimulation via attenuating the activation of NF-κB and MAPK signaling pathways and decreasing the levels of pro-inflammatory mediators. This offers a novel perspective for understanding the anti-inflammatory mechanism of CAI and suggests its potential use as a therapeutic treatment in inflammatory diseases with excessive macrophage activation.
- [VIRTUAL] Anti-Amyloidogenic and Cyclooxygenase Inhibitory Activity of Indigofera zollingeriana Miq () - Aug 2, 2020 - Abstract #AAIC2020AAIC_3417;
This offers a novel perspective for understanding the anti-inflammatory mechanism of CAI and suggests its potential use as a therapeutic treatment in inflammatory diseases with excessive macrophage activation. The results suggest that Indigofera zollingeriana Miq possesses anti-inflammatory and anti-neurodegenerative properties and a promising lead as a source of pharmacologically active compounds.
- | indomethacin / PLx Pharma Inc, Generic mfg., Tectin (tetrodotoxin) / WEX
Journal: TRPA1 causes rapid bronchodilation via non-epithelial PGE. (Pubmed Central) - Jul 29, 2020
Finally, AITC blocked airway hyperreactivity in two animal models of allergic asthma. These data demonstrate that stimulation of TRPA1 causes bronchodilation of intact airways and suggest that the TRPA1 pathway is a potential pharmacologic target for bronchodilation.
- | sulindac / Generic mfg.
Journal: Ellagic Acid Inhibits Extracellular Acidity-Induced Invasiveness and Expression of COX1, COX2, Snail, Twist 1, and c-myc in Gastric Carcinoma Cells. (Pubmed Central) - Jul 21, 2020
In addition, acidity increased the mRNA protein expression of transcription factors snail, twist1, and c-myc; these were also reduced by ellagic acid. Together, these results suggest that ellagic acid suppresses acidity-enhanced migration and invasion of gastric cancer cells via inhibition of the expression of multiple factors (COX1, COX2, snail, twist1, and c-myc); for this reason, it may be an effective agent for cancer treatment under acidosis.
- | Preclinical, Journal: Inhibition of lipolysis: a novel explanation for the hypothermic actions of Acetaminophen in Non-Febrile Rodents. (Pubmed Central) - Jul 21, 2020
These novel observations combined with the known limited inhibition of the COX enzymes by acetaminophen suggest both the antipyretic and hypothermia induced by acetaminophen and related compounds could be attributed to the direct inhibition of lipolysis and mitochondrial function, rather than cyclooxygenase inhibition centrally. Further these observations could provide new drug targets for reducing fever with the added bonus of fewer individuals being hospitalized by accidental acetaminophen overdose.
- | verapamil / Generic mfg.
Preclinical, Journal: Vasorelaxant effect of osthole on isolated thoracic aortic rings in rats. (Pubmed Central) - Jul 21, 2020
Further these observations could provide new drug targets for reducing fever with the added bonus of fewer individuals being hospitalized by accidental acetaminophen overdose. Osthole has a vasorelaxant effect on isolated rat thoracic aortic rings, via inhibition of both receptor-operated and voltage-dependent Ca2+ channels in arterial smooth muscle, leading to decreased Ca2+ influx, and via inhibition of nitric oxide release on arterial endothelial cells.
- | celecoxib oral / Generic mfg.
Preclinical, Journal: Anti-nociceptive and Anti-inflammatory Activities of Asparacosin A Involve Selective Cyclooxygenase 2 and Inflammatory Cytokines Inhibition: An in-vitro, in-vivo, and in-silico Approach. (Pubmed Central) - Jul 16, 2020
However, in formalin test, Asparacosin A (10-40 mg/kg, p.o) produced anti-nociceptive effects only in the late phase, similar to the effect observed with the reference drug celecoxib (50 mg/kg, p.o)...In conclusion, Asparacosin A exhibits anti-inflammatory and peripheral anti-nociceptive activities which are likely mediated via inhibition of COX-2 enzyme and inflammatory cytokines. Furthermore, Asparacosin A can serve as a model to obtain new and more selective potent anti-inflammatory and anti-nociceptive drugs.
- | celecoxib oral / Generic mfg.
Journal: 2,5-Dimethylcelecoxib prevents isoprenaline-induced cardiomyocyte hypertrophy and cardiac fibroblast activation by inhibiting Akt-mediated GSK-3 phosphorylation. (Pubmed Central) - Jul 16, 2020
Moreover, we found that phosphatase and tensin homolog on chromosome 10 (PTEN) could be a molecule to mediate the effect of DM-celecoxib on Akt. These results suggest that DM-celecoxib directly improves the structure and function of cardiomyocytes and cardiac fibroblasts and that this compound could be clinically useful for the treatment of β -adrenergic receptor-mediated maladaptive cardiac remodeling.
- | Preclinical, Journal: Protective Effects of Sesamin against UVB-Induced Skin Inflammation and Photodamage In Vitro and In Vivo. (Pubmed Central) - Jul 16, 2020
These results demonstrate that sesamin had antiphotodamage and anti-inflammatory activities. Sesamin has potential for use as a skin protection agent in antiphotodamage and skin care products.
- | ibuprofen / Generic mfg.
Journal: Ester coupling of ibuprofen in hydrogel matrix: a facile one-step strategy for controlled anti-inflammatory drug release. (Pubmed Central) - Jul 16, 2020
In particular, we tested the biological activity of cleaved ibuprofen in terms of cyclooxygenase inhibition, reporting that chemical tethering did not alter the efficiency of the NSAID. Moreover, due to the sol-gel transition of the hydrogel matrix, these ibuprofen-functionalized hydrogels could be used as injectable tools in several clinical scenarios, performing a localized drug release and opening advanced avenues for in situ treatments.
- | aspirin / Generic mfg.
Journal: Cardiovascular Biology of Prostanoids and Drug Discovery. (Pubmed Central) - Jul 16, 2020
Substantial variation in clinical responses to aspirin exists and is associated with cardiovascular risk...mPGES-1-derived PGE critically regulates microcirculation via its receptor EP (receptor for prostanoid E) 4. This review summarizes the actions and associated mechanisms for modulating the biosynthesis of prostanoids in thrombosis, vascular remodeling, and ischemic heart disease as well as their therapeutic relevance.
- || cisplatin / Generic mfg., methotrexate / Generic mfg., sulfasalazine / Generic mfg.
Clinical, Journal, Relative risk: Relative risk of end-stage renal disease requiring dialysis in treated ankylosing spondylitis patients compared with individuals without ankylosing spondylitis: A nationwide, population-based, matched-cohort study. (Pubmed Central) - Jul 16, 2020
This review summarizes the actions and associated mechanisms for modulating the biosynthesis of prostanoids in thrombosis, vascular remodeling, and ischemic heart disease as well as their therapeutic relevance. The risk of ESRD was not significantly different between treated AS patients and non-AS individuals matched for age, sex, year of index date and dose of NSAID.
- Opdivo (nivolumab) / Ono Pharma, BMS
[VIRTUAL] Association between cyclooxygenase inhibitor use and efficacy of immunotherapy: a retrospective study (Pre-congress content) - Jul 15, 2020 - Abstract #ERS2020ERS_2257;
In total, 214 patients with NSCLC received ICIs: nivolumab (137, 64%), pembrolizumab (52, 24%), or atezolizumab (25, 12%). There was no additional effect of COX-I use on the efficacy of ICIs in NSCLC.
- Prexige (lumiracoxib) / Novartis, indomethacin / PLx Pharma Inc, Generic mfg.
[VIRTUAL] A novel protective role of prostaglandin D2 in antigen-induced bronchoconstriction (Pre-congress content) - Jul 15, 2020 - Abstract #ERS2020ERS_2155;
In GPT, challenge with OVA (100 µg/mL) induced a constrition (Emax of 54±6%) that was enhanced by the unselective COX inhibitor indomethacin (Emax:94±2%; p<0.05)...Selective inhibition of COX-2 by lumiracoxib did not inhibit release of PGD2 or TXA2... Endogenous PGD2 is generated via COX-1 and mediates a previously unknown inhibitory effect of the antigen-induced bronchoconstriction via DP1 receptors inhibiting mast cell release.
- | indomethacin / PLx Pharma Inc, Generic mfg.
Journal: The effect of pulmonary surfactant on the airway smooth muscle after lipopolysaccharide exposure and its mechanisms. (Pubmed Central) - Jul 9, 2020
The exogenous surfactant has relaxing effect on the ASM, but does not reverse LPS-induced smooth muscle contraction. The results further indicate participation of prostanoids and potential involvement of leukotriene and histamine H1 receptors in the airway smooth muscle contraction during LPS exposure.
- [VIRTUAL] Human Rhinovirus Infection of Primary Bronchial Epithelial Cells Upregulates Prostaglandin E2 Production That Attenuates Transforming Growth Factor Beta-1-Induced Fibroblast-to-Myofibroblast Transition (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_1443;
Lack of FMT-stimulation by HRV may be because HBEC and HBF were from healthy donors who did not display airway remodeling when infected in vivo with HRV. Future studies using HBEC and HBF from asthmatic individuals are planned to determine if a different pattern is observed.
- lorazepam / Generic mfg.
[VIRTUAL] Chronic Lorazepam-Induced Pro-Relaxant Signaling in ASM Cells Is Cyclooxygenase Dependent (ATS 2020 Virtual) - Jul 6, 2020 - Abstract #ATSI2020ATS-I_832;
Chronic, but not necessarily acute, treatment of human ASM cells with lorazepam activates both COX-1 and COX-2-mediated pathway. Future studies will be aimed at examining downstream synthesis of prostaglandin E2 and the role of E-type prostanoid receptor subtypes in mediating lorazepam-induced pro-relaxant signals in ASM cells.
- | glibenclamide / Generic mfg., dalfampridine / Generic mfg.
Preclinical, Journal: 4-Aminopyridine, a Voltage-Gated K Channel Inhibitor, Attenuates Nitric Oxide-Mediated Vasodilation of Retinal Arterioles in Rats. (Pubmed Central) - Jul 3, 2020
Intravitreal injection of indomethacin (a non-selective cyclooxygenase inhibitor) also reduced the NOR3-induced retinal vasodilator response...These results suggest that the vasodilatory effects of NO are mediated, at least in part, through the activation of 4-aminopyridine-sensitive K channels in the retinal arterioles of rats. NO exerts its dilatory effect on the retinal vasculature of rats through at least two mechanisms, activation of the K channels and enhancement of prostaglandin production.
- | Journal: Evaluation of Analgesic and Antiplatelet Activity of 2-((3-(chloromethyl)benzoyl)oxy)benzoic acid. (Pubmed Central) - Jul 2, 2020
Overall, this study demonstrated a successful synthesis of pure 2-((3-(chloromethyl)benzoyl)oxy) benzoic acid. We postulated that this compound was better than acetylsalicylic acid, exhibiting excellent analgesic and antiplatelet activity with no toxicity impact.