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78 Companies | 115 Products |
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115 Products | |
266 Diseases | |
841 Trials |  |
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- | fluconazole / Generic mfg.
Journal: Glechoma curviflora Volatile Oil from Palestine: Chemical Composition and Neuroprotective, Antimicrobial, and Cyclooxygenase Inhibitory Activities. (Pubmed Central) - Dec 12, 2020
It also showed anti-Candida (MIC = 6.25 μg/mL) and antimold (MIC = 3.125 μg/mL) activities compared with fluconazole (antifungal positive control). Likewise, our results showed an inhibition and biophysical impact of G. curviflora on all AMPARs subunits.
- | Preclinical, Journal: Phytochemical investigation, anti-inflammatory, antipyretic and antinociceptive activities of Zanthoxylum armatum DC extracts-in vivo and in vitro experiments. (Pubmed Central) - Dec 10, 2020
This study rationalize the usage of this spice in traditional medicine for management of pain and inflammation involving LOX and COX inhibition as possible mechanism. GC-MS analysis revealed the presence of various constituents which might contributed towards the pain and inflammation alleviation.
- || RQ-00317076 (AAT-076) / RaQualia
#EuropeanPatentOffice Approves Formulation Patent for #AskAts #COX2Inhibitor (#AAT076) https://t.co/pw36bGrHuY (Twitter) - Dec 4, 2020
- | Journal, IO Biomarker: Aloperine suppresses LPS-induced macrophage activation through inhibiting the TLR4/NF-κB pathway. (Pubmed Central) - Dec 2, 2020
GC-MS analysis revealed the presence of various constituents which might contributed towards the pain and inflammation alleviation. Taken together, our findings show that Aloperine could suppress LPS-induced macrophage activation by inhibiting the TLR4/Myd-88/NF-κB pathway.
- | Journal: Design and efficient synthesis of pyrazoline and isoxazole bridged indole C-glycoside hybrids as potential anticancer agents. (Pubmed Central) - Dec 2, 2020
Mechanistic studies showed that, active compounds inhibit COX-2 enzyme, which was also supported by molecular docking studies. These findings are expected to provide new leads towards anticancer drug discovery.
- | deferiprone / Generic mfg.
Journal: Antiplatelet activity of deferiprone through cyclooxygenase-1 inhibition. (Pubmed Central) - Nov 27, 2020
Moreover, the results from molecular docking showed that deferiprone interacted closely with key residues in the peroxidase active site of COX-1. These results suggested that deferiprone possessed antiplatelet activity mainly through the inhibition of COX-1 activity.
- | naproxen / Generic mfg.
Preclinical, Journal: Naproxen platinum(iv) hybrids inhibiting cycloxygenases and matrix metalloproteinases and causing DNA damage: synthesis and biological evaluation as antitumor agents in vitro and in vivo. (Pubmed Central) - Nov 26, 2020
The naproxen platinum(iv) complex could easily undergo reduction and liberate the platinum(ii) complex and naproxen as well as exert a multifunctional antitumor mechanism: (i) the liberated platinum(ii) fragment would cause serious DNA injury; (ii) naproxen would inhibit COX-2 and decrease tumor-associated inflammation; and (iii) the naproxen platinum(iv) complex exhibited remarkable MMP-9 inhibition in tumor tissues. These antitumor functions can help reduce the growth and metastasis of malignancy.
- | Journal: Sex-differences in cholinergic, nicotinic, and β-adrenergic cutaneous vasodilation: Roles of nitric oxide synthase, cyclooxygenase, and K channels. (Pubmed Central) - Nov 26, 2020
Irrespective of sex, NOS inhibition or K channel blockade attenuated isoproterenol-mediated cutaneous vasodilation, whereas K channel blockade decreased nicotine-induced cutaneous vasodilation. Tagen together, our findings indicate that while the mechanisms underlying cutaneous vasodilation are comparable between young men and women, sex-related differences in the magnitude of cutaneous vasodilation do exist and this response differs as a function of the receptor agonist.
- | indomethacin / PLx Pharma Inc, Generic mfg.
Journal: Tocolytic effect of the monoterpenic phenol isomer, carvacrol, on the pregnant rat uterus. (Pubmed Central) - Nov 26, 2020
The aim of this study was to evaluate the in vitro tocolytic effect of CAR on the contractility of isolated pregnant rat uterus in the presence of a calcium channel antagonist (nifedipine) and a cyclooxygenase inhibitor (indomethacin)...Therefore, the tocolytic effect induced by CAR was associated with the blockade of the calcium channels in the pregnant rat uterus. This property placed CAR as a potentially safe and effective adjuvant agent in cases of preterm labor, an area of pharmacological treatment that requires urgent improvement.
- | Journal: The combination of bromelain and curcumin as an immune-boosting nutraceutical in the prevention of severe COVID-19. (Pubmed Central) - Nov 21, 2020
Notably, bromelain substantially increases the absorption of curcumin after oral administration. To the best of our knowledge, this is the first report highlighting the significance of bromelain and, most importantly, the potential preventive value of the synergistic effects of bromelain and curcumin against severe COVID-19.
- | Preclinical, Journal: Oral Intake of EPA:DHA 6:1 by Middle-Aged Rats for One Week Improves Age-Related Endothelial Dysfunction in Both the Femoral Artery and Vein: Role of Cyclooxygenases. (Pubmed Central) - Nov 19, 2020
Both the non-selective cyclooxygenase inhibitor indomethacin and the COX-1 inhibitor SC-560 increased the relaxation to acetylcholine in the middle-aged femoral artery whereas the COX-2 inhibitor NS-398 increased that in the middle-aged femoral vein. In conclusion, our results indicate that aging is associated with an endothelial dysfunction in the femoral artery and vein, which can be improved by EPA:DHA 6:1 treatment-most likely via a cyclooxygenase-dependent mechanism.
- | Preclinical, Journal: Nicotinic acid promotes sleep through prostaglandin synthesis in mice. (Pubmed Central) - Nov 14, 2020
Systemic administration of monomethyl fumarate, another agonist of the nicotinic acid receptor GPR109A, fully recapitulated the somnogenic and thermoregulatory effects of nicotinic acid suggesting that they are mediated by the GPR109A receptor. The cyclooxygenase inhibitor indomethacin completely abolished the effects of nicotinic acid indicating that prostaglandins play a key role in mediating the sleep and thermoregulatory responses of nicotinic acid.
- | Journal: Structure-Activity Relationships of Pentacyclic Triterpenoids as Inhibitors of Cyclooxygenase and Lipoxygenase Enzymes. (Pubmed Central) - Nov 14, 2020
Also, the presence of an α-hydroxy group at C-2 or a carboxylic acid group at C-23 markedly suppressed the 5-LOX activity. The present findings reveal that the types and configurations of polar moieties at positions C-2, -3, -11, -24, and -30 are important structural aspects of pentacyclic triterpenes for their potential as anti-inflammatory lead compounds.
- | Nevanac (nepafenac) / Novartis
Journal: Mechanisms and Treatment of Light-Induced Retinal Degeneration-Associated Inflammation: Insights from Biochemical Profiling of the Aqueous Humor. (Pubmed Central) - Nov 14, 2020
Interestingly, the most prominent antioxidant and anti-inflammatory benefits and overall retinal protective effects are achieved by simultaneous administrating of both drugs indicating their synergistic action. Taken together, these findings provide a rationale for using a combination of mitochondria-targeted antioxidant and cyclooxygenase inhibitor for the treatment of inflammatory components of retinal degenerative diseases.
- | Journal: Inhibition of cyclooxygenase-1 by nonsteroidal anti-inflammatory drugs demethylates MeR2 enhancer and promotes Mbnl1 transcription in myogenic cells. (Pubmed Central) - Nov 14, 2020
These results suggest that COX-1 inhibition upregulates Mbnl1 transcription through demethylation of the MeR2 enhancer. Taken together, our study provides new insights into the transcriptional regulation of Mbnl1 by the COX-1-mediated pathway.
- | Journal: Metabolite profiling and mechanisms of bioactivity of snake autolysate - A traditional Uzbek medicine. (Pubmed Central) - Nov 7, 2020
The results from GC-MS analyses of SNA lead us to the identification of a wide range of major chemical structures of the metabolites and their derivatives with several categories. Pharmacological studies support the traditional use of SNA and show one of its possible mechanisms of activity via inhibition of hyaluronidase.
- | glibenclamide / Generic mfg.
Journal: Blood pressure lowering effect and vascular activity of Phyllanthus niruri extract: The role of NO/cGMP signaling pathway and β-adrenoceptor mediated relaxation of isolated aortic rings. (Pubmed Central) - Nov 7, 2020
Pharmacological studies support the traditional use of SNA and show one of its possible mechanisms of activity via inhibition of hyaluronidase. This study indicates that the antihypertensive activity of P. niruri extract is mediated by vasoactive phytoconstituents that dilate the arterial wall via endothelium-dependent pathways and β-adrenoceptor activity which, in turn, cause vasorelaxation and reduce blood pressure.
- | indomethacin / PLx Pharma Inc, Generic mfg.
Preclinical, Journal: Gastroprotective activity of hydroalcoholic extract of the leaves of Urera baccifera in rats. (Pubmed Central) - Nov 7, 2020
Together, the results confirmed that the gastroprotection elicited by HEU was due reduction in oxidative damage, neutrophil migration, and peptic activity. This work validates the popular use of U. baccifera to treat gastric disorders and supports important future research for the identification of gastroprotective molecules from this species.
- | ibuprofen / Generic mfg.
Preclinical, Journal: Cyclooxygenase activity in bradykinin-induced dermal extravasation. A study in mice and humans. (Pubmed Central) - Nov 7, 2020
These data suggest that COX activity contributes to bradykinin-induced dermal extravasation in mice and humans. In addition, our findings may open new treatment options and point to a potential activity of drugs interfering with the release of the COX substrate arachidonic acid, e.g. glucocorticoids.
- | Journal: Evaluation of Cytotoxic Potentials of Novel Cyclooxygenase-2 Inhibitor Against ALL Lymphocytes and Normal Lymphocytes and Its Anticancer Effect Through Mitochondrial Pathway. (Pubmed Central) - Nov 6, 2020
Taken together, the results of this study suggest that cancerous mitochondria are a potential target for the ALL B-lymphocytes. Selective toxicity of COX-2 inhibitor in cancerous mitochondria could be an attractive therapeutic option for the effective clinical management of therapy-resistant ALL.
- | Preclinical, Journal: Pellucidin A promotes antinociceptive activity by peripheral mechanisms inhibiting COX-2 and NOS: In vivo and in silico study. (Pubmed Central) - Nov 6, 2020
Our results demonstrate that the antinociceptive activities of Pellucidin A operate under mechanism(s) of peripheral action, involving inflammatory mediators. This work provides insightful novel evidence of the biological properties of Pellucidin A, and leads to a better understanding of its mechanism of action, pointing to potential pharmacological use.
- | Scenesse (afamelanotide) / Clinuvel
Journal: Topical MTII Therapy Suppresses Melanoma Through PTEN Upregulation and Cyclooxygenase II Inhibition. (Pubmed Central) - Nov 3, 2020
Melanotan II (MTII), a synthetic analogue of the alpha-melanocyte stimulating hormone (α-MSH), has been applied for skin tanning in humans...Together, these results indicate that MTII elicits PTEN upregulation via MC1R, thereby suppressing melanoma progression through downregulating COX-2/PGE2 signaling. Hence, topical MTII therapy may facilitate a novel therapeutic strategy against melanoma.
- | Journal: Design, synthesis and biological evaluation of novel pyrazole sulfonamide derivatives as dual COX-2/5-LOX inhibitors. (Pubmed Central) - Nov 2, 2020
The prodrug ester derivatives 6c and 6d showed equipotent activity to their parent compound 5b with no gastric ulcerogenicity. Molecular docking simulations confirmed that the newly synthesized compounds possess the structural features required for binding to the target enzymes COX-2 and 5-LOX.
- | ibuprofen / Generic mfg.
Journal: Short-term application of ibuprofen before ovulation. (Pubmed Central) - Nov 1, 2020
Logistic regression showed no significant association of ibuprofen intake, LH- level or reason for infertility on embryo quality. Based on our results, we suggest that, particularly within natural cycle IVF, ibuprofen does no harm around ovulation as analgesic treatment.
- | doxorubicin hydrochloride / Generic mfg.
Journal: Synthesis, antitumor activity, and molecular docking study of 2-cyclopentyloxyanisole derivatives: mechanistic study of enzyme inhibition. (Pubmed Central) - Oct 30, 2020
Compounds 4a, 7b, and 13 inhibited PDE4B (IC values: 5.62, 5.65, and 3.98 μM, respectively) compared with the reference drug roflumilast (IC=1.55 μM). The molecular docking of compounds 4b and 13 with the COX-2 and PDE4B binding pockets was studied.HighlightsAntitumor activity of new synthesized cyclopentyloxyanisole scaffold was evaluated.The powerful antitumor 4a, 4b, 6b, 7b & 13 were assessed as COX-2, PDE4B & TNF-α inhibitors.Compounds 4a, 7b, and 13 exhibited COX-2, PDE4B, and TNF-α inhibition.Compounds 4b and 13 showed strong interactions at the COX-2 and PDE4B binding pockets.
- | ibuprofen / Generic mfg.
Journal: Exploring the fatty acid amide hydrolase and cyclooxygenase inhibitory properties of novel amide derivatives of ibuprofen. (Pubmed Central) - Oct 30, 2020
However, this concentration of Ibu-AM68 greatly reduced the ability of the COX-2 to catalyse the cyclooxygenation of the endocannabinoid 2-arachidonoylglycerol. It is concluded that Ibu-AM68 is a dual-acting FAAH/substrate-selective COX inhibitor.
- | indomethacin / PLx Pharma Inc, Generic mfg.
Journal: Sex differences in vascular reactivity of coronary artery bypass graft conduits. (Pubmed Central) - Oct 28, 2020
(1) Concentration response curves for PE and ET-1 were generated in an intact IMA and SV and endothelium denuded IMA segments, (2) in the presence of the nitric oxide synthase inhibitor (L-NAME) or the cyclooxygenase inhibitor (indomethacin) in an endothelium-intact IMA and (3) the activity state (abundance and phosphorylation) of the α-adrenergic receptor was investigated using Phos-tag™ western blot analysis...Female IMA and SV graft conduits are hypersensitive to α-adrenergic stimuli. This endothelial cyclooxygenase pathway-mediated hypersensitivity may produce excessive IMA and SV graft constriction in females administered catecholamines and could contribute to their poorer CABG outcomes.
- | Preclinical, Journal: Eukaryotic elongation factor 2 kinase inhibitor, A484954 lowered blood pressure in spontaneously hypertensive rats via inducing vasorelaxation. (Pubmed Central) - Oct 28, 2020
A484954 promoted the dimerization of eNOS in human endothelial cells. In summary, we have revealed A484954 lowers BP in SHR perhaps through the vasorelaxation via the production of endothelium-derived relaxing factors.
- | allopurinol / Generic mfg.
Journal: Large health benefits can be achieved by better treatment of gout (Pubmed Central) - Oct 27, 2020
Allopurinol is the first line choice of ULT and should be started with low dose, which is increased until the treatment target is reached...NSAID/cox-inhibitors, colchicine and glucocorticoids are all valid short-term treatments of gout attacks...Recent RCTs of ULT treatment have demonstrated the importance of thorough and adequate information to the patient and regular follow-up until treatment targets are reached. Such a strategy improve both compliance and outcomes of ULT treatment.
- | Journal: In Vivo Effects of Nonselective, Partially Selective, and Selective Non Steroidal Anti-Inflammatory Drugs on Lipid Peroxidation and Antioxidant Enzymes in Patients with Rheumatoid Arthritis: A Clinical Study. (Pubmed Central) - Oct 26, 2020
Diclofenac, meloxicam, and celecoxib carry antioxidant effects to a variable extent. NSAID possesses additional mechanism independent of COX inhibition which modulates oxidative stress.
- | ibuprofen / Generic mfg.
Journal: Anti-Inflammatory and Anticoagulant Activities of Synthesized NSAID Prodrug Esters. (Pubmed Central) - Oct 26, 2020
The results showed an improved COX inhibition and anticoagulant activity compared with their parent drugs. The synthesized drugs are expected to improve patient's compliance in terms of administration frequency and will have better pharmacokinetic properties with fewer side effects.
- | Journal: Synthesis and biological evaluation of tetrazole derivatives as TNF-α, IL-6 and COX-2 inhibitors with antimicrobial activity: Computational analysis, molecular modeling study and region-specific cyclization using 2D NMR tools. (Pubmed Central) - Oct 24, 2020
Appreciable binding interactions were observed for compound 7c containing COX-2 pharmacophore (SONH), with binding energy -10.6652 Kcal/mol, forming two hydrogen bonding interactions with His90 and Tyr355 amino acids. It was fully fitted within COX-2 active site having the highest COX-2 selectivity index between all the test compounds (S.I. = 16.91).
- | Journal: NF-κB "decoy" inhibits COX-2 expression in epileptic rat brain. (Pubmed Central) - Oct 24, 2020
In the experimental group compared to the control group, the nuclear factor-kappa B expression in the hippocampal dentate gyrus, cerebral cortex, piriform cortex, and other brain regions was significantly lower (P < 0.01), with the accompanying decrease in cyclooxygenase-2 protein and mRNA expression (P < 0.01) in the hippocampus. In conclusion, κB-decoy can inhibit nuclear factor kappa B activation in epileptic rat brain and cyclooxygenase-2 overexpression.
- | Journal: Essential role of prostaglandin E and the EP3 receptor in lymphatic vessel development during zebrafish embryogenesis. (Pubmed Central) - Oct 22, 2020
Finally, we generated EP3-deficient zebrafish, which also showed defect in lymphatic specification and development. Thus, we demonstrated that COX1-derived PGE-EP3 pathway is required for embryonic lymphatic development by upregulating the expression of key factors for the lymphatic specification.
- | Journal: Molecular Imaging of Inflammation in Osteoarthritis Using a Water-Soluble Fluorocoxib. (Pubmed Central) - Oct 20, 2020
COX-2-selectivity was verified either by blocking the enzyme's active site with celecoxib or by molecular imaging with nontargeted 5-carboxy-X-rhodamine dye. These data indicate that fluorocoxib D is an ideal candidate for early detection of inflammatory or neoplastic lesions expressing elevated levels of COX-2.
- | Preclinical, Journal: Co-nanoencapsulated meloxicam and curcumin improves cognitive impairment induced by amyloid-beta through modulation of cyclooxygenase-2 in mice. (Pubmed Central) - Oct 20, 2020
This study was approved by the Committee on Care and Use of Experimental Animal Resources, the Federal University of Pampa, Brazil (approval No. 02-2015) on April 16, 2015.
- | Journal: Pyridine- and Thiazole-Based Hydrazides with Promising Anti-inflammatory and Antimicrobial Activities along with Their In Silico Studies. (Pubmed Central) - Oct 15, 2020
The in silico molecular docking study revealed their COX-inhibitory action. Compound 5j emerged as a significant bioactive molecule among the synthesized analogues.
- [VIRTUAL] ANGINA AND ATRIAL FIBRILLATION IN MELOXICAM USE () - Oct 12, 2020 - Abstract #CHEST2020CHEST_976;
Given the negative work up and resolution following discontinuation of the agent, the patient’s angina and atrial fibrillation were likely associated with meloxicam use. Further prospective studies should be performed to assess association of non selective COX inhibitors in development of acute cardiac events and long term cardiovascular mortality.
- | Journal: TRAIL-Receptor 4 Modulates γδ T Cell-Cytotoxicity Toward Cancer Cells. (Pubmed Central) - Oct 10, 2020
In conclusion, we uncovered an unexpected novel role of TRAIL-R4 in tumor cells. In contrast to its known pro-tumoral, anti-apoptotic function, TRAIL-R4 augments the anti-tumoral cytotoxic activity of γδ T cells.
- ||| Clinical: Anyone using NSAIDs/COX inhibitors for prevention in FAP patients outside the setting of a clinical trial? @agrothey @evilarsan (Twitter) - Oct 9, 2020
- [VIRTUAL] Treatment with Selective Cyclooxygenase-2 Inhibitors Is Associated with Inhibition of Radiographic Spinal Progression in Patients with Axial Spondyloarthritis: Long-term Results from the German Spondyloarthritis Inception Cohort (Feed 11) - Oct 8, 2020 - Abstract #ACRARHP2020ACR_ARHP_2762;
Coxibs (i.e., celecoxib, etoricoxib and rofecoxib) were considered selective COX-2 inhibitors, all other NSAIDs – as non-selective ones. An inhibitory effect of NSAIDs on radiographic spinal progression in this axSpA cohort was attributable to the COX-2 selective inhibitors.
- | cisplatin / Generic mfg.
Journal: A coassembled peptide hydrogel boosts the radiosensitization of cisplatin. (Pubmed Central) - Oct 3, 2020
We constructed a novel supramolecular hydrogel by carrying out a coassembly of cisplatin and short naproxen-capped peptides. This procedure boosted the radiosensitization effect of cisplatin by increasing the number of Pt-DNA adducts, arresting the cell cycle, and inhibiting cyclooxygenase-2.
- | pioglitazone / Generic mfg.
Journal: Suppressive role of PPARγ in the IgE-dependent activation of mast cells. (Pubmed Central) - Oct 2, 2020
Oral administration of pioglitazone (PPARγ agonist) significantly suppressed body temperature change of mice in passive systemic anaphylaxis, supporting the inhibitory functions of PPARγ in IgE/Ag-dependent activation of MCs in vivo...Knockdown of COX-1 and/or COX-2 by siRNA showed that suppression of IgE/Ag-mediated activation was mainly dependent on COX-1. Taken together, these results indicate that PPARγ suppresses IgE/Ag-induced transactivation of cytokine genes and the Ptgs2 gene in MCs in a manner distinguishable from that of PGs.
- | Review, Journal: Introduction: Druggable Lipid Signaling Pathways. (Pubmed Central) - Oct 2, 2020
The review chapters include lipid signaling pathways (prostanoids, leukotrienes, epoxy fatty acids, sphingolipids, lysophospholipids, endocannabinoids, and phosphoinositides) and lipid signaling proteins (lysophospholipid acyltransferases, phosphoinositide 3-kinase, and G protein-coupled receptors (GPCRs)). Drugs targeting lipid signaling pathways promise to be life changing magic for the future of human health and well-being.
- | doxorubicin hydrochloride / Generic mfg., irinotecan / Generic mfg., ibuprofen / Generic mfg.
Journal: Thiohydantoin derivatives incorporating a pyrazole core: Design, synthesis and biological evaluation as dual inhibitors of topoisomerase-I and cycloxygenase-2 with anti-cancer and anti-inflammatory activities. (Pubmed Central) - Oct 1, 2020
Regarding anti-cancer activity, most of the target derivatives showed activities against A-549, MCF-7 and HCT-116 cell lines (IC = 5.32-17.90, 3.67-19.04 and 3.19-14.87 µM respectively) in comparison with doxorubicin (IC = 0.20, 0.50 and 2.44 µM respectively)...respectively in comparison with camptothecin (IC = 20.2 µg/ml). Additionally, COX-2 and human topoisomerase-1 docking studies were carried out to explain the interaction of the synthesized hybrid structures 14a-l with the target enzymes.
- | indomethacin / PLx Pharma Inc, Generic mfg.
Journal: Role of Arginase in Selective Impairment of Endothelium-Dependent Nitric Oxide Synthase-Mediated Dilation of Retinal Arterioles during Early Diabetes. (Pubmed Central) - Sep 30, 2020
In the presence of L-NAME and COX inhibitor indomethacin, histamine-induced dilations of control and diabetic vessels were reduced similarly...Arginase, rather than superoxide, impairs endothelium-dependent NOS-mediated dilation of retinal arterioles during diabetes, whereas vasodilation mediated by COX remains intact. Blockade of vascular arginase may improve endothelial function of retinal arterioles during early onset of diabetes.
- | Dynastat (parecoxib) / Pfizer
Preclinical, Journal: Parecoxib improves the cognitive function of POCD rats via attenuating COX-2. (Pubmed Central) - Sep 27, 2020
Blockade of vascular arginase may improve endothelial function of retinal arterioles during early onset of diabetes. Parecoxib improves the cognitive function of POCD rats via inhibiting COX-2 overexpression in rat brain.
- | Journal: Nonsteroidal Anti-Inflammatory Drugs (NSAIDs) and Their Effect on Musculoskeletal Soft-Tissue Healing: A Scoping Review. (Pubmed Central) - Sep 26, 2020
In contrast, the majority of studies demonstrate that nonselective COX inhibitors have no negative effect on musculoskeletal soft-tissue healing. Additional high-quality human clinical trials are necessary to provide more definitive conclusions.
- | imipramine / Generic mfg., indomethacin / Generic mfg.
Preclinical, Journal: Indomethacin, a nonselective cyclooxygenase inhibitor, does not interact with MTEP in antidepressant-like activity, as opposed to imipramine in CD-1 mice. (Pubmed Central) - Sep 25, 2020
We found that, in contrast to COX-2 inhibition, indomethacin - acting both through COX-1 and COX-2 - did not release antidepressant-like potential of MTEP. The opposite effect was shown when imipramine was used.
- | celecoxib oral / Generic mfg.
Preclinical, Journal: 5-Thioxoimidazolidine-2-one derivatives: Synthesis, anti-inflammatory activity, analgesic activity, COX inhibition assay and molecular modelling study. (Pubmed Central) - Sep 24, 2020
Mostly, all of our synthesized compounds have greater activity more than celecoxib toward both cyclooxygenase enzymes...Furthermore, the analgesic activity of such compounds was also determined. Molecular modeling study was also conducted to rationalize the potential as anti-inflammatory agents of our synthesized compounds by predicting their binding modes, binding affinities and optimal orientation at the active site of the COX enzymes.