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78 Companies | 115 Products |
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115 Products | |
266 Diseases | |
841 Trials |  |
49644 News |  |
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- | celecoxib oral / Generic mfg.
Review, Journal, IO biomarker: Celecoxib in oncology: targeting the COX-2/PGE2 axis to reprogram the tumor immune microenvironment and enhance multimodal therapy. (Pubmed Central) - Dec 12, 2025
Despite the breakthrough of celecoxib in the field of oncology treatment, large-scale trials are warranted to validate its long-term safety and biomarker-driven accuracy. This work underscores the potential of celecoxib as a cornerstone in multimodal cancer therapy and provides a roadmap for its integration into personalized treatment paradigms.
- | indomethacin / Generic mfg., naproxen / Generic mfg., celecoxib oral / Generic mfg.
Journal: Celecoxib and naproxen disrupt autophagy and activate EGR1 in kidney tubules. (Pubmed Central) - Dec 11, 2025
Our study reveals dose-dependent tubulotoxic effects of NSAIDs unrelated to their COX-selectivity, suggesting an interplay between pro-fibrotic transcription factor EGR1, autophagy pathways and oxidative stress. These findings underscore the need for meticulous dose optimization especially in kidney disease patients in order to reduce nephrotoxicity.
- | indomethacin / Generic mfg., omeprazole / Generic mfg.
Journal, IO biomarker: Syringic acid protects against indomethacin-induced gastric injury via NF-?B and apoptotic pathway modulation. (Pubmed Central) - Dec 11, 2025
Syringic acid may confer gastroprotective effects against indomethacin-induced gastric injury by modulating oxidative stress, inflammation, and apoptosis. While less potent than omeprazole, its multi-target actions suggest potential value as an adjunctive strategy for COX inhibitor-induced gastric damage.
- | pentoxifylline / Generic mfg.
Review, Journal: Role of brain-gut axis in mechanism of gastrointestinal defense. (Pubmed Central) - Dec 9, 2025
Pharmacological agents, affecting mucosal blood flow, such as cyclooxygenase (COX) products, COX inhibitors and pentoxifylline, are also able to modify functions of the brain-gut axis. We conclude that brain-gut axis plays a particularly important role in maintaining of mucosal barrier in GI-tract and alteration in its functions is implicated in pathogenesis of various diseases of the gut.
- | Journal: Neuro-protection of swertisin against impairment induced by A?25-35 by acting on COX-2 to up-regulate 2-AG and suppressing neuroinflammation. (Pubmed Central) - Dec 5, 2025
Finally, it was confirmed that swertisin alleviated BV-2 cell apoptosis induced by A?25-35. These results help us understand the mechanism of swertisin against AD and promote the development of related drugs and healthy products.
- | dexamethasone / Generic mfg., indomethacin / Generic mfg., celecoxib oral / Generic mfg.
Preclinical, Journal: Anti-inflammatory activity of 7-methoxycoumarin isolated from Ayapana triplinervis Vahl (Compositae) via inhibition of inflammatory mediators - In-vivo, in-vitro and in-silico studies. (Pubmed Central) - Nov 27, 2025
These results help us understand the mechanism of swertisin against AD and promote the development of related drugs and healthy products. The present study demonstrated the anti-inflammatory potential of 7-methoxycoumarin and provide pharmacological support for the traditional use of Ayapana triplinervis in wound healing.
- | Preclinical, Journal: Exploring the Analgesic and Antidiarrheal Properties of Angelicin Through Cyclooxygenase Inhibition and ?-Opioid Receptor Interaction: In Vivo and In Silico Studies. (Pubmed Central) - Nov 26, 2025
These results strongly suggest that AGN is a promising dual-action therapeutic candidate for pain and diarrhea, likely mediated through COX inhibition and MOR interaction. Further studies are warranted to validate these mechanisms and develop optimized AGN-based formulations for clinical translation.
- | Journal: Trans-cinnamaldehyde alleviates IFN-?-induced depressive-like behaviors by restoring astrocytic Cx43 gap junction. (Pubmed Central) - Nov 21, 2025
Crucially, astrocyte-specific Cx43 knockout (Gfap-Cre; Cx43fl/fl) mice exhibited depression-like phenotypes and hyperactivated neuroinflammation, abolishing TCA's therapeutic effects. These results demonstrate that TCA mitigates IFN-?-induced depression by modulating astrocytic Cx43 gap junctions and inhibiting COX-2/NF-?B-driven neuroinflammation, positioning it as a novel immunopharmacological agent for inflammation-associated depression and highlighting Cx43 as a potential therapeutic target.
- | Journal: Cyanide overproduction impairs cellular bioenergetics in Down syndrome. (Pubmed Central) - Nov 19, 2025
Cyanide and H2S may act cooperatively on the same molecular target. These results open the possibility of developing therapeutic strategies that target cyanide or both cyanide and H2S to counteract DS-associated metabolic impairment.
- | dexamethasone injection / Generic mfg.
Journal: Implication of Preoperative Intravenous Dexamethasone on Pain and Nausea in Late-Stage Elderly Total Knee Arthroplasty Patients: a randomized double-blind trial. (Pubmed Central) - Nov 19, 2025
Preoperative administration of 10 mg IV dexamethasone to relatively healthy late-stage elderly patients (American Society of Anesthesiologists Physical Status I to II) undergoing TKA significantly reduced postoperative pain and PONV without increasing wound complications or infections. However, caution should be exercised when extrapolating these results to more comorbid populations, and further research is needed to assess long-term outcomes and broader applicability.
- | indomethacin / Generic mfg.
Preclinical, Journal: Cyclooxygenase Inhibitor 4-Methylthiazole Derivative Compound Alleviates Lipopolysaccharides-Induced Neuroinflammation in Male Rats With Regulating Cytokine Levels. (Pubmed Central) - Nov 19, 2025
The efficacy of the MET compound was also compared with one of the reference drugs, the nonselective COX inhibitor indomethacin (INDO)...Especially when TNF-?, IL-6 and IL-10 results were compared with INDO, anti-inflammatory activity was found to be high. Our results revealed that MET compound may suppress LPS-induced neuroinflammation via COX enzyme inhibition as well as downregulation of pro-inflammatory cytokines and M1 phenotype microglia.
- | Review, Journal: Do nonsteroidal anti-inflammatory drugs increase the risk of atrial fibrillation after non-cardiac surgery? Insights from translational and clinical research. (Pubmed Central) - Nov 19, 2025
In this context, perioperative clinicians face the challenge of optimizing pain control while mitigating cardiovascular risk. This review synthesizes preclinical, translational, and clinical data to delineate the potential impact of NSAIDs on POAF risk after non-cardiac surgery, providing a framework for evidence-informed perioperative management.
- | caffeine citrate / Generic mfg.
Journal: Caffeine-Associated Reduction in Patent Ductus Arteriosus (PDA) is Mediated in Part by Adenosine Receptor Antagonism. (Pubmed Central) - Nov 19, 2025
Pressure myography was used to examine responses of the isolated ductus to adenosine, caffeine (citrate or base), or preincubation with either caffeine or adenosine...In conclusion, caffeine did not induce direct ductus constriction ex vivo. However, caffeine exposure prevented adenosine-induced ductus relaxation, suggesting inhibition of an endogenous vasodilator as a mechanism for reduction in PDA.
- | Review, Journal: Post-Operative Bleed Risks Associated with Perioperative Nonsteroidal Anti-Inflammatory Drugs: A Narrative Review. (Pubmed Central) - Nov 19, 2025
COX-2 selective NSAIDs may be a safer alternative to nonselective NSAIDs, with some studies indicating a lower risk of post-operative bleeding following their use. Ultimately, the decision to use NSAIDs in the perioperative period should be tailored to the specific surgical procedure and individual patient factors.
- | Journal, HEOR, Real-world evidence: Herbal analgesic patches versus NSAIDs in soft tissue injury management: real-world comparative effectiveness from a 35-center chinese prospective cohort of 1378 participants. (Pubmed Central) - Nov 17, 2025
GTP is a safe NSAIDs alternative, especially for patients with comorbidities. Monotherapy or a 2-week SCI-to-GTP transition is recommended because of the lack of combination synergy.
- || Clinical, Retrospective data, Journal: Do Nonsteroidal Anti-Inflammatory Drugs Increase Bleeding Risk After Craniotomy for Brain Surgery? A Systematic Review and Meta-Analysis. (Pubmed Central) - Nov 14, 2025
Monotherapy or a 2-week SCI-to-GTP transition is recommended because of the lack of combination synergy. Our findings suggest that NSAIDs are a safe option for postoperative analgesia in patients undergoing craniotomy for brain surgery, because they do not significantly increase the risk of bleeding complications, including those requiring surgical intervention, compared with non-NSAID analgesics.
- | Journal: Exploiting the 2-(1,3,4,9-tetrahydropyrano[3,4-b]indol-1-yl)acetic Acid Scaffold to Generate COXTRANs: A New Class of Dual Cyclooxygenase Inhibitors-Thromboxane Receptor Antagonists. (Pubmed Central) - Nov 13, 2025
Further studies in human whole blood and physicochemical profiling allowed the prioritization of 51 (CXT29) as a suitable candidate for in vivo studies. Compound 51, after oral administration, was able to prevent TP receptor-mediated platelet aggregation and to reduce inflammatory pain in mice.
- | flurbiprofen / Generic mfg., ibuprofen / Generic mfg.
Journal: Novel Ruthenacarborane-NSAID Conjugates. (Pubmed Central) - Nov 13, 2025
Notably, the conjugates demonstrated low COX inhibition and no cytotoxic potential against different cancer cell lines, probably due to oxidative deactivation confirmed by cyclic voltammetry (CV). This indicates that the conjugation of this type of ruthenacarborane with NSAIDs does not result in novel anticancer drugs.
- | Review, Journal: Therapeutic approach to COPD by targeting pulmonary associated cell signaling pathways. (Pubmed Central) - Nov 12, 2025
This has important implications in terms of Cyclooxygenase inhibitor use in asthma and COPD. Understanding these molecular mechanisms can pave the way for precision medicine approaches in COPD management.
- | Journal: A Cautionary Tale: Non-steroidal anti-inflammatory drug use and localized provoked vulvodynia. (Pubmed Central) - Nov 12, 2025
PERSPECTIVE: Taking NSAIDs to manage chronic vulvar pain may downregulate levels of specialized pro-resolving lipid mediators, thereby resulting in prolonged pain and delayed inflammation resolution. This study provides one possible explanation for clinical reports of the ineffectiveness of NSAIDs in the mitigation of vulvodynia-associated pain.
- || PK/PD data, Journal: Pharmacokinetics of carprofen in Siamese crocodiles (Crocodylus siamensis). (Pubmed Central) - Nov 12, 2025
These findings indicate sustained systemic exposure and high bioavailability of CAR in C. siamensis, supporting its potential as a long-acting analgesic. Future studies should assess pharmacodynamic responses and therapeutic efficacy in clinical settings to optimize dosing regimens.
- | Preclinical, Journal: Xiaoke Decoction Inhibits COX-2-Mediated LDLr Pathway Dysfunction and Protects Renal Function in Diabetic Nephropathy Rats. (Pubmed Central) - Nov 4, 2025
Future studies should assess pharmacodynamic responses and therapeutic efficacy in clinical settings to optimize dosing regimens. XKD alleviates renal tissue damage by regulating the COX-2-mediated LDLr pathway, thereby reducing the release of inflammatory factors and lipid accumulation in DN rats and protecting renal function.
- Risk of secondary chronic myeloid leukemia in cancer survivors: A nationwide population-based study in Taiwan (OCCC - West Halls B3-B4) - Nov 4, 2025 - Abstract #ASH2025ASH_3278;
Male sex, diabetes, andheart failure were independently associated with increased risk. These findings support long-termhematologic surveillance in high-risk cancer survivors.
- | dexamethasone / Generic mfg.
Journal: Enhanced corneal permeation of diclofenac through an ophthalmic nanocrystal suspension. (Pubmed Central) - Nov 2, 2025
Clinical studies show it provides anti-inflammatory benefits comparable to dexamethasone but with a lower risk of increasing intraocular pressure...In summary, the developed nanosuspensions offer a promising strategy for improving DCF ocular delivery and therapeutic efficacy. Further clinical studies are needed to confirm long-term safety and effectiveness in humans.
- | Journal: Antimicrobial effects and mechanisms of hydrogen sulphide against nail pathogens. (Pubmed Central) - Nov 1, 2025
COX inhibition likely causes electron leakage, generating ROS and oxidising cysteine residues, which then react with H2S to form S-sulfhydrated proteins. This novel mechanism, along with the ability of H2S to penetrate the nail, suggests topical delivery of an H2S donor is a promising new treatment for onychomycosis.
- | Journal, IO biomarker: Cardioprotective effects of Bassia indica via NF-?B and BCL-2/BAX modulation in isoproterenol-induced myocardial injury. (Pubmed Central) - Oct 30, 2025
Pretreatment with BiE significantly reduced the infarct size; preserved cardiac tissue architecture; lowered cardiac biomarkers (cTnI, CK-MB, LDH, and AST); downregulated NF-?B, COX-2, TNF-?, and IL-1?; and upregulated IL-10 and BCL-2. These findings suggest that BiE has cardioprotective effects that are mediated by the suppression of inflammation and apoptosis.
- | Journal: Trifluoromethyl-pyrazole-carboxamides as COX inhibitors: synthesis, microed structural analysis, computational profiling, and biological evaluation. (Pubmed Central) - Oct 30, 2025
Additionally, compound 3a displayed moderate cytotoxic effects against several cancer cell lines, suggesting possible dual anti-inflammatory and anticancer potential. Overall, the favorable drug-like properties and low toxicity profiles justify further preclinical investigation of these pyrazole-carboxamide derivatives.
- | Preclinical, Journal: Kaempferol Regulates Lipid Homeostasis, Endocannabinoid System, and PPAR? in Rat Cerebral Cortex Following BCCAO/R. (Pubmed Central) - Oct 29, 2025
In summary, these findings demonstrate that KAM exerts dual anti-inflammatory effects by inhibiting COX-2-mediated prostanoid synthesis and promoting PPAR?-driven lipid signaling. This dual mechanism highlights the potential of KAM as a dietary intervention to reduce neuroinflammation associated with hypoperfusion-reperfusion challenges.
- | Journal: Protective Effects of Microsorum scolopendria (Burm.f.) Copel. Leaf and Rhizome Extracts on Oxidative Stress and Inflammation Induced by Staphylococcus aureus and Staphylococcus epidermidis. (Pubmed Central) - Oct 29, 2025
These results highlight differential biological performance between leaf and rhizome extracts, with RH showing slightly higher anti-inflammatory activity but also a modest cytotoxic effect at intermediate concentrations. Overall, MS extracts demonstrated protective effects against oxidative and inflammatory damage induced by bacterial infection, supporting their potential as safe natural therapeutic agents for managing infection-associated skin stress and inflammation.
- | Journal: Harmaline attenuates pain and inflammation: role of IL-1?, oxidative stress, nitric oxide and cyclo-oxygenase. (Pubmed Central) - Oct 26, 2025
Overall, this study demonstrates that harmaline effectively alleviates pain and inflammation through the inhibition of COX and nitric oxide pathways, alongside the activation of Nrf-2-antioxidant signaling. These findings support harmaline's potential as a therapeutic agent for pain and inflammation, warranting further research into its clinical applications.
- | Journal: Platelet COX and LOX Enzymes Orchestrate Amyloid-? Secretion via RhoA Signaling: Implications for Neurodegenerative Diseases. (Pubmed Central) - Oct 19, 2025
Given the vascular deposition of A?40 in CAA, our results position platelets as important peripheral contributors to neurovascular amyloidosis. This study should therefore be viewed as hypothesis-generating, underscoring the therapeutic potential of targeting platelet signaling pathways to mitigate A?-driven vascular pathology.
- | Review, Journal: Traditional Applications, Phytochemical Constituents, and Pharmacological Properties of Lavandula multifida L.: A Review. (Pubmed Central) - Oct 16, 2025
This review concludes by identifying key research priorities for L. multifida, including a detailed analysis of its non-volatile compounds, mechanistic elucidation, toxicological assessments, and standardization of extracts. Addressing these gaps is essential to validate its traditional applications and advance its development into evidence-based phytomedicines, adjuvant therapies, and natural agrochemicals.
- | Preclinical, Journal: Hepatoprotective potential of Diospyros melanoxylon (Roxb.) leaf extract by inhibition of IL-6, COX-2, and 5-LOX expression in paracetamol intoxicated rats. (Pubmed Central) - Oct 10, 2025
Addressing these gaps is essential to validate its traditional applications and advance its development into evidence-based phytomedicines, adjuvant therapies, and natural agrochemicals. MDML shows dose-dependent hepatoprotection against PCM-induced toxicity, likely due to the presence of UA, supporting its traditional use in liver disorders.
- indomethacin / Generic mfg.
Pharmacologically-induced neurovascular uncoupling in rats: model development challenges and insights (Poster Area; In-person) - Oct 10, 2025 - Abstract #ECNP2025ECNP_1436;
In the current study, we employed a translationally relevant cohort of aged (~27.5 months old), cognitively experienced Long Evans rats (n=25). The three inhibitors were combined into a single-solution ("cocktail") and administered intraperitoneally twice daily for 14 days at individually tailored dosages.
- | ibuprofen / Generic mfg.
Journal: Hybrid Conjugates of Ibuprofen and 3,5-Diarylidene-4-Piperidone: A New Avenue in Anti-Inflammatory Drug Discovery. (Pubmed Central) - Oct 7, 2025
Computational studies, including molecular docking and ADME (absorption, distribution, metabolism, and excretion) analyses, are performed to clarify the mechanisms of action and to predict pharmacokinetic properties. The findings indicate that some hybrid conjugates display promising anti-inflammatory properties, necessitating further investigation for their potential therapeutic applications.
- | Zyflo (zileuton) / Chiesi
Journal: Flufenamic acid-based sulfonohydrazide and acetamide derivatives NSAI as inhibitors of multi-targets COX-1/COX-2/5-LOX: design, synthesis, in (Pubmed Central) - Oct 4, 2025
The findings indicate that some hybrid conjugates display promising anti-inflammatory properties, necessitating further investigation for their potential therapeutic applications. Meclofenamic and Zileuton are examples of dual COX/LOX inhibitors that provide improved stomach protection and safer cardiovascular characteristics...The COX-1 inhibition of compounds 14 and 15 was higher than that of Celecoxib (IC50?=?77.4
- | indomethacin / Generic mfg.
Journal: Theory for the structural relaxation and self-diffusion of amorphous indomethacin under various thermodynamic conditions. (Pubmed Central) - Oct 1, 2025
This cost-saving approach helps satisfactorily explain experimental observations without any fitting procedures. Our theoretical results would have profound implications for enhancing the applicability of amorphous indomethacin to disease treatment and prevention.
- | Journal: Lipidomics-Guided Ultrasound-Assisted Ethanol Extraction of Avocado Pulp and Evaluation of Bioactive Properties. (Pubmed Central) - Sep 30, 2025
This method is greener than traditional ones and produces extracts with antioxidant and anti-inflammatory benefits. These natural extracts can be used food, cosmetic, and nutraceutical or supplement industries as natural ingredients applications.
- | naproxen / Generic mfg., celecoxib oral / Generic mfg.
Journal: Nitrogen Monoxide Releasing Nitric Ester Derivatives of Ibuprofen and Naproxen as COX Inhibitors, Anti-Inflammatory and Hypolipidemic Compounds. (Pubmed Central) - Sep 27, 2025
In conclusion, the performed structural modifications resulted not only in the improvement of the anti-inflammatory activity, compared with the parent NSAID, but also acquired strong hypolipidemic activity. Thus, the combination of structural characteristics resulting in a decrease in lipidemia, with possible inhibition of atherosclerosis, due to their anti-inflammatory activity and vasodilatation ability, via the liberated NO, may constitute a useful rationale for new compounds.
- | Journal: Impact of Adding GLP-1 Receptor Agonists to Insulin Therapy on Cardiovascular and Microvascular Outcomes in Type 2 Diabetes: A Nationwide Cohort Study from Taiwan. (Pubmed Central) - Sep 27, 2025
In this nationwide cohort, adding GLP-1 RAs to insulin therapy in patients with T2D was associated with significantly lower risks of cardiovascular events, major microvascular complications, and all-cause mortality compared with adding DPP-4 inhibitors. These findings suggest that incorporating GLP-1 RAs into insulin regimens may optimize treatment, lessen disease burden, and improve survival.
- || aspirin / Generic mfg., ibuprofen / Generic mfg., naproxen / Generic mfg.
Retrospective data, Journal, Adverse events: Pharmacovigilance Insights into Ibuprofen's Neuropsychiatric Safety: A Retrospective Analysis of EudraVigilance Reports. (Pubmed Central) - Sep 27, 2025
A limitation of the study can be noted as due to suspected causality, not an established one, and EV reports cannot accurately determine adverse drug reaction frequencies. Considering that ibuprofen is easily accessible as an OTC drug and the higher probability of reporting several neuropsychiatric adverse effects as shown by this study, patient counseling, when possible, and general education for the public are valuable tools in managing these adverse reactions.
- | Journal: From By-Product to Bioactive Molecular Ingredient: The Impact of Cranberry Pomace on Antioxidant Properties and Enzyme Modulation in Functional Biscuits. (Pubmed Central) - Sep 27, 2025
Moreover, extracts from digested biscuits reduced oxidative stress in Saccharomyces cerevisiae and inhibited COX-1, COX-2, and AChE activities, suggesting potential anti-inflammatory and neuroprotective effects. These findings highlight cranberry pomace as a sustainable, high-value ingredient for functional foods, aligning with circular economy strategies.
- | Journal: Inhibitory Infrared Light Attenuates Mitochondrial Hyperactivity and Accelerates Restoration of Mitochondrial Homeostasis in an Oxygen-Glucose Deprivation/Reoxygenation Model. (Pubmed Central) - Sep 27, 2025
IRL treatment suppressed ROS production, decreased the level of cell death, and reduced the time to normalize mitochondrial activity to baseline levels from 4-5 to 2.5 h of reperfusion time. We show that IRL treatment is protective by limiting ??m hyperpolarization and ROS production, and by speeding up cellular recovery.
- | indomethacin / Generic mfg.
Journal: Extracellular Vesicles from Post-COVID-19 Patients Alter Endothelial Function Under Protein Restriction. (Pubmed Central) - Sep 26, 2025
These findings suggest that EVs from patients 1 and 6 months after severe COVID-19 impact aortic endothelial function by increasing H?O? contribution under conditions of malnutrition.
- | Journal: Prostacyclin assists in the repair of ruptured amnions through the proliferation and migration of amnion mesenchymal cells. (Pubmed Central) - Sep 25, 2025
In vitro, the proliferation and migration of cultured human amnion mesenchymal cells were stimulated by an IP agonist and inhibited by an IP antagonist. These findings suggest that PGI2 facilitates amnion repair by promoting the proliferation and migration of amnion mesenchymal cells.
- || ketorolac / Generic mfg.
PK/PD data, Journal: Pharmacokinetic Comparison of Novel Tablet-in-Tablet and Conventional Ketorolac Tromethamine Tablets in Beagle Dogs. (Pubmed Central) - Sep 24, 2025
These findings suggest that PGI2 facilitates amnion repair by promoting the proliferation and migration of amnion mesenchymal cells. The results of this study suggest that the development of a novel KT tablet formulation utilizing the push-pull osmotic pump (PPOP) and tablet-in-tablet techniques warrants further investigation in clinical trials.
- | Journal: Angiotensinogen II Receptor Blockers May Decrease Risk of Adhesive Capsulitis After Rotator Cuff Repair. (Pubmed Central) - Sep 22, 2025
Once diagnosed with AC, there was no difference in odds of undergoing MUA or LOA among any of the medication groups. Level III, retrospective cohort study.
- | celecoxib oral / Generic mfg.
Preclinical, Journal: Multi-scale investigation of PQ3-quinoxaline derivatives as selective COX-2 inhibitors: synthesis, structural analysis, DFT, MD simulations, and in silico/in vitro evaluation. (Pubmed Central) - Sep 18, 2025
Level III, retrospective cohort study. In contrast, the remaining derivatives (PQ3b-d) demonstrated weak or non-selective COX inhibition compared to the reference drug celecoxib (COX-2 IC50
- | naproxen / Generic mfg.
Journal: Self-Assembling Hydrogels of Naproxen-Conjugated Peptides for Osteoarthritis Treatment. (Pubmed Central) - Sep 18, 2025
In vivo experiments demonstrate the NpxFFK hydrogel significantly mitigated articular degradation in OA rats, outperforming clinical treatments (naproxen treatment or hyaluronic acid treatment), thereby validating its therapeutic potential for OA. By integrating NSAID pharmacology with self-assembling peptide hydrogel delivery platform, we present a multifunctional strategy that significantly improves upon current OA treatments, underscoring its promise for translational healthcare innovation in OA management.
- | meropenem / Generic mfg.
Journal: Single and Combined Effects of Meropenem, Valproic Acid, and Ketoprofen on Adult Zebrafish Behavior, Oxidative Stress, and Acetylcholinesterase Activity. (Pubmed Central) - Aug 28, 2025
Moreover, AChE activity was more strongly inhibited in zebrafish exposed to the binary and ternary mixtures than to individual drugs. The results indicate that acute exposure to individual and/or combined pharmaceuticals induces behavioral changes, oxidative damage, and AChE inhibition in zebrafish, highlighting the need to assess the effects of pharmaceutical mixtures for comprehensive ecosystem risks evaluation.