COX inhib News - LARVOL Sigma

«1 2...12 13 14 15 161718 19 20 21 22...31 32 »

|||||||||| morphine sulphate / Generic mfg.
EVALUATION OF INTRAVENOUS KETOROLAC IN CARDIOTHORACIC SURGERY PATIENTS ([VIRTUAL]) - Mar 23, 2022 - Abstract #SCCM2022SCCM_1934;
The use of IV ketorolac did not reduce post-operative opioid use in CABG patients compared to CPM at POD2. Further studies are warranted to fully understand if ketorolac plays a meaningful role in the post-operative pain management of patients undergoing CABG.

|||||||||| Journal: Biological effect and chemical monitoring of Watch List substances in European surface waters: Steroidal estrogens and diclofenac - Effect-based methods for monitoring frameworks. (Pubmed Central) - Mar 17, 2022
Comparison between effect-based and conventional analytical chemical methods showed that the chemical analytical approach for steroidal estrogens resulted in more (76%) non-quantifiable data, i.e., concentrations were below detection limits, compared to the EBMs (28%). These results demonstrate the excellent and sensitive screening capability of EBMs.

|||||||||| indomethacin / Generic mfg., sulindac / Generic mfg.
Preclinical, Journal: Assessment of NSAIDs as potential inhibitors of the fatty acid amide hydrolase I (FAAH-1) using three different primary fatty acid amide substrates in vitro. (Pubmed Central) - Mar 17, 2022
These results demonstrate the excellent and sensitive screening capability of EBMs. Our data therefore suggest potential for study of these compounds as combined FAAH-1-COX inhibitors.

|||||||||| Journal: Neurotoxic, biotransformation, oxidative stress and genotoxic effects in Astyanax altiparanae (Teleostei, Characiformes) males exposed to environmentally relevant concentrations of diclofenac and/or caffeine. (Pubmed Central) - Mar 17, 2022
Caffeine alone produces genotoxicity on this species but, when combined with diclofenac, it potentiates hepatic lipoperoxidation and the inhibition of oxidative stress enzymes, while diclofenac alone or in combination produces a general inhibition of important enzymes. This study suggests that aquatic contamination produced by these pharmaceuticals has the potential to affect homeostasis and locomotion in A. altiparanae and compromise their immune system and general health.

|||||||||| Victoza (liraglutide) / Novo Nordisk
Preclinical, Journal: Noninvasive assessment of coronary microvascular dysfunction using SPECT myocardial perfusion imaging and myocardial perfusion entropy quantification in a rodent model of type 2 diabetes. (Pubmed Central) - Mar 15, 2022
Both MPE and capillary density quantification suggested that LIR did not improve T2D-induced CMVD. The relevance of MPE for CMVD assessment warrants further clinical investigation.

|||||||||| Journal: Myeloid cyclooxygenase-2/prostaglandin E2/E-type prostanoid receptor 4 promotes transcription factor MafB-dependent inflammatory resolution in acute kidney injury. (Pubmed Central) - Mar 12, 2022
Myeloid Mafb deletion recapitulated the effects seen with either myeloid COX-2 or EP4 deletion following acute kidney injury, with delayed recovery, persistent presence of pro-inflammatory kidney macrophages, and increased kidney fibrosis. Thus, our studies identified a previously unknown mechanism by which prostaglandins modulate macrophage phenotype following acute organ injury and provide new insight into mechanisms underlying detrimental kidney effects of non-steroidal anti-inflammatory drugs that inhibit cyclooxygenase activity.

|||||||||| cisplatin / Generic mfg.
Preclinical, Journal: Development of methylated cobalt-alkyne complexes with selective cytotoxicity against COX-positive cancer cell lines. (Pubmed Central) - Mar 12, 2022
The reduced growth-inhibitory potency in T-24 cells, which express distinctly fewer COX enzymes (COX-1/COX-2 = 50/1) than HT-29 cells (COX-1/COX-2 = 50/50), and the only marginal activity in COX-negative MCF-7 breast cancer cells point to an interference in the arachidonic acid cascade through COX-2 inhibition as part of the mode of action, especially as the cellular uptake was even higher in MCF-7 cells than in T-24 cells. These findings clearly demonstrate that the methylated cobalt-alkyne complexes possess promising potential for further development as reasonable alternatives to the limited platinum-based antitumor agents.

|||||||||| ibuprofen / Generic mfg.
Review, Journal: Management of the patent ductus arteriosus in preterm infants. (Pubmed Central) - Mar 12, 2022
High-dose ibuprofen may be preferable, especially for preterm infants beyond the first 3 to 5 days of age. If pharmacotherapy fails (after two courses) or is contraindicated, procedural closure may be considered for infants with a persistent PDA with significant clinical symptoms in addition to echocardiographic signs of a large PDA shunt volume and pulmonary over-circulation.

|||||||||| carfilzomib / Generic mfg.
Journal, IO biomarker: Carfilzomib inhibits the proliferation and apoptosis of multiple myeloma cells by inhibiting STAT1/COX-2/iNOS signaling pathway. (Pubmed Central) - Mar 11, 2022
Western blot also verified that carfilzomib promoted STAT1 inhibition and subsequently inhibited COX-2 and iNOS. Inhibition of the STAT1/COX-2/iNOS signaling pathway by carfilzomib not only inhibited MM cell proliferation, but was also an important mechanism of inducing MM cell apoptosis.

|||||||||| Quantification of oxylipins as biomarkers of inflammation and cancer risk in breast tissue (E-Poster Website) - Mar 9, 2022 - Abstract #AACR2022AACR_5298;
We conclude that eicosanoids can be readily measured in small frozen breast tissue samples obtained via percutaneous biopsy or at surgery. Future studies to assess the associations of eicosanoid levels with BC risk factors and development of BC after a benign biopsy may inform risk prediction and potentially inhibitable inflammatory mechanisms of breast carcinogenesis.

|||||||||| In vivo CRISPR screening identifies mediators of immune evasion in KRAS-mutant lung cancer (Section 37) - Mar 9, 2022 - Abstract #AACR2022AACR_3378;
Together these data suggest that targeting KRAS-driven mechanisms of immune evasion could broaden the clinical efficacy of immunotherapy in KRAS-mutant NSCLC.Since the approval of immunotherapy, a novel class of mutant-specific KRAS-G12C inhibitors have recently been approved for the treatment of KRAS-mutant NSCLC, however acquired drug resistance is common. We are therefore also currently investigating whether the inhibition of the COX-2/PGE2 axis enhances the therapeutic benefit of KRAS-G12C inhibitors.

|||||||||| Effects of sulindac on inflammatory and cellular responses in mammary tumors from obese mice (Section 36) - Mar 9, 2022 - Abstract #AACR2022AACR_3347;
The study suggests that sulindac can reverse transcriptional changes in mammary tumors from obese mice and restore immunosurveillance. Sulindac, or potentially other NSAIDs, may protect against obesity--driven mammary tumor growth via remodeling of antitumor immune function.

|||||||||| ibuprofen / Generic mfg.
Journal: Selenium Ameliorates Ibuprofen Induced Testicular Toxicity by Redox Regulation: Running Head: Se protects against NSAID induced testicular toxicity. (Pubmed Central) - Mar 8, 2022
Alternatively, Se supplementation through antioxidant enzymes mediated protective effects. Se as essential antioxidant selenoproteins ameliorates Ibuprofen induced male reproductive toxicity.

|||||||||| cisplatin / Generic mfg., ibuprofen / Generic mfg.
Preclinical, Journal: Cisplatin-cyclooxygenase inhibitor conjugates, free and immobilised in mesoporous silica SBA-15, prove highly potent against triple-negative MDA-MB-468 breast cancer cell line. (Pubmed Central) - Mar 8, 2022
Flow cytometry assays clearly show that all compounds induce apoptotic cell death elevating the levels of both early and late apoptotic cells. Furthermore, autophagy as well as formation of reactive oxygen species (ROS) and nitric oxide (NO) were elevated to a similar or greater extent than with cisplatin.

|||||||||| Preclinical, Journal: Intact prostaglandin signaling through EP2 and EP4 receptors in stromal progenitor cells is required for normal development of the renal cortex in mice. (Pubmed Central) - Mar 8, 2022
This study shows the distinct localization of EP receptors in mice. Functionally we could identify EP2 and EP4 receptors in stromal FoxD1 progenitor cells as essential receptor subtypes for normal renal development.

|||||||||| Journal: Flavonoids: Antiplatelet Effect as Inhibitors of COX-1. (Pubmed Central) - Mar 5, 2022
The results obtained showed that quercetin and diosmetin aglycones have a greater antiplatelet effect and inhibit the COX enzyme activity to a greater extent than their heterosides; however, the fact that greater inhibition of the pure recombinant enzyme was achieved by heterosides suggests that these compounds may have difficulty in crossing biological membranes. In any case, in view of the results obtained, it can be concluded that flavonoids could be useful as coadjuvants in the treatment of cardiovascular pathologies.

|||||||||| indomethacin / Generic mfg.
Preclinical, Journal: Cyclooxygenase-dependent mechanisms mediate in part the anti-dilatory effects of perivascular adipose tissue in uterine arteries from pregnant rats. (Pubmed Central) - Mar 3, 2022
Arteries were exposed to Krebs-Henseleit solution (control) or PVAT-conditioned media (PVATmedia) in the presence of the following inhibitors: L-NAME (NOS inhibitor), indomethacin (COX inhibitor), SC560 (COX-1 inhibitor), NS398 (COX-2 inhibitor), SQ 29,548 (thromboxane receptor (TP) inhibitor)...Incubation of uterine arteries from pregnant rats with PVATmedia increased production of thromboxane B (TxB, p=0.01) but thromboxane receptor (TP) inhibition did not affect the anti-dilatory properties of PVATmedia. In conclusion, inhibition of COX signaling suppressed the anti-dilatory effects of PVATmedia, while PVATmedia had no effect on the contribution of the NOS/NO pathway to ACh-induced relaxation in uterine arteries from pregnant rats, indicating that the anti-dilatory effects of uterine PVAT are mediated in part by COX-dependent mechanisms.

|||||||||| Journal: Different forms of vitamin E and metabolite 13'-carboxychromanols inhibit cyclooxygenase-1-catalyzed thromboxane in platelets, and tocotrienols and 13'-carboxychromanols are competitive inhibitors of 5-lipoxygenase. (Pubmed Central) - Feb 26, 2022
Our study reveals inhibitory effects of vitamin E forms and 13'-COOHs on COX-1 activity and thromboxane formation in platelets, and elucidates mechanisms underlying their inhibition of 5-LOX. These observations are useful for understanding the role of these compounds in disease prevention and therapy.

|||||||||| Journal: Enhancement of the Colorectal Chemopreventive and Immunization Potential of Northern Thai Purple Rice Anthocyanin Using the Biotransformation by β-Glucosidase-Producing Lactobacillus. (Pubmed Central) - Feb 26, 2022
Moreover, it also showed a potent inhibitory effect on proinflammatory cytokine interleukin-6 (IL-6) secretion and an induction effect on anti-inflammatory cytokine IL-10 secretion. These documents highlight the potential to be used of the anthocyanin extract after 12 h of biotransformation by L. plantarum FR332 as a natural active pharmaceutical ingredient (NAPI) for colorectal chemoprevention and immunization.

|||||||||| Journal: Effects of short-term heat acclimation on whole-body heat exchange, and local NOS- and COX-dependent heat loss responses in exercising older men. (Pubmed Central) - Feb 25, 2022
NOS inhibition alone reduced cutaneous vascular conductance to a similar extent before and after acclimation (p < 0.040), whereas separate and combined NOS and COX inhibition had no significant effects on sweating relative to the control site (p = 0.745). Our preliminary results may suggest that short-term heat acclimation improves evaporative heat loss, but it does not significantly modulate NOS or COX contributions to cutaneous vasodilation or sweating on the forearm in older men during an exercise-heat stress.

|||||||||| celecoxib oral / Generic mfg.
Review, Journal: New horizons in the roles and associations of COX-2 and novel natural inhibitors in cardiovascular diseases. (Pubmed Central) - Feb 24, 2022
The combination of galangin-like flavonol compounds with these prodrug metabolites may lead to the development of novel COX-2 inhibitors. This review focuses on the most compelling evidence regarding the role and mechanism of COX-2 in cardiovascular diseases and demonstrates that quercetin-like compounds exert potential cardioprotective effects by serving as cofactors of COX-2.

|||||||||| Journal: LC-ESI-MS/MS Characterization of Concentrated Polyphenolic Fractions from Rhododendron luteum and Their Anti-Inflammatory and Antioxidant Activities. (Pubmed Central) - Feb 24, 2022
It reveals, for the first time, the presence of dihydromyricetin, afzelin, and laricitrin in the plant material. It indicates biologically active polyphenolic fractions that should be further investigated or which could be efficiently used in pharmaceutical, cosmetic, or nutraceutical applications.

|||||||||| fluconazole oral / Generic mfg., ibuprofen / Generic mfg., voriconazole / Generic mfg.
Journal: Fluconazole-COX Inhibitor Hybrids: A Dual-Acting Class of Antifungal Azoles. (Pubmed Central) - Feb 19, 2022
The hybrids were active against a mutant lacking CYP51, the target of azole drugs, indicating that these agents act via a dual mode of action. This study established that azole-COX inhibitor hybrids are a novel class of potent antifungals with clinical potential.

|||||||||| Journal: Antiarthritic activity of OA-DHZ; a gastroprotective NF-κB/MAPK/COX inhibitor. (Pubmed Central) - Feb 17, 2022
In contrast to the results obtained from in vivo experimentation, there is a disparity in the pharmacokinetic profile of OA-DHZ, where it showed low oral exposure and high clearance rate. OA-DHZ being antiarthritic acting via NF-κB /MAPK/ COX inhibition while showing gastroprotective effects, can be a suitable candidate to be in the drug pipeline and further exploration.

|||||||||| Journal: Activity-Guided Characterization of COX-2 Inhibitory Compounds in Waltheria indica L. Extracts. (Pubmed Central) - Feb 17, 2022
The results of the predictive models further suggested that the compounds contribute to COX-2 inhibition in the order linoleic acid > alpha linolenic acid > steroidal saponins > triterpenoid saponins. The characterization of substances contributing to COX-2 inhibition in this study enables a more targeted development of extraction processes to obtain Waltheria indica extracts with superior anti-inflammatory properties.

|||||||||| Clinical, Journal: Genotoxic effects of Dukhan: A smoke bath from the wood of Acacia seyal used traditionally by Sudanese women. (Pubmed Central) - Feb 15, 2022
The findings indicated a dose dependent genotoxic potential of the smoke condensate in the bacterial and human C3A cells and may pose a health risk to women since the smoke bath is frequently practised. The study highlighted the need for further rigorous assessment of the risks associated with the smoke bath practice.

|||||||||| celecoxib oral / Generic mfg.
Journal: Effects of Celecoxib Adjunct to Selective Serotonin Reuptake Inhibitors on Obsessive-Compulsive Disorder. (Pubmed Central) - Feb 15, 2022
There was a significant difference between the study groups in obsession (F= 49.19, df= 1, P≤0.001), compulsion (F= 13.78, df= 1, P= 0.001), and OCD (F= 57.25, df= 1, P≤0.001), i.e., higher in the celecoxib group. This study showed that adjuvant treatment with celecoxib can further improve the symptoms of OCD in individuals receiving SSRIs.

|||||||||| paracetamol / Generic mfg.
Review, Journal: Pharmacological hypotheses: Is acetaminophen selective in its cyclooxygenase inhibition? (Pubmed Central) - Feb 12, 2022
Thus, we suggest with specificity to human in vivo physiology that ACT: (i) does not act on a third COX isoform; (ii) is not selective in its COX inhibition; and (iii) inhibition of COX isoforms are determined by subtle and nuanced physiological variations. Robust research designs are required in humans to objectively confirm these hypotheses.

|||||||||| celecoxib oral / Generic mfg.
Review, Journal: Recent advances in molecular pathways and therapeutic implications targeting neuroinflammation for Alzheimer's disease. (Pubmed Central) - Feb 12, 2022
Non-selective COX inhibitor indomethacin is also potent inhibitor of inflammatory mediators released from microglia...Mitophagy induction is also beneficial in the removal of damaged mitochondria and reduction of infiltration of inflammatory molecules at the site of accumulation of the damaged mitochondria. Targeting these pathways and eventually ameliorating the activation of microglia can mitigate neuroinflammation and come out as a better therapeutic option for the treatment of Alzheimer's disease.

|||||||||| meloxicam / Generic mfg.
Journal: Marek's Disease Virus Modulates T Cell Proliferation via Activation of Cyclooxygenase 2-Dependent Prostaglandin E2. (Pubmed Central) - Feb 12, 2022
Interestingly, oral administration of a COX-2 inhibitor, meloxicam, during MDV infection inhibited COX-2 activation and rescued T cell proliferation at day 21 post infection. Taken together, our results reveal a novel mechanism that contributes to immunosuppression in the MDV-infected chickens.

|||||||||| flurbiprofen / Generic mfg.
Journal: Effects of flurbiprofen on the functional regulation of serotonin transporter and its misfolded mutant. (Pubmed Central) - Feb 11, 2022
In HRD1 E3 ubiquitin ligase knockdown cells, flurbiprofen affected the ER-associated degradation system. Collectively, the findings suggest that flurbiprofen may function as an inducer of molecular chaperones, in addition to functioning as a chemical chaperone.

|||||||||| ibuprofen / Generic mfg.
Preclinical, Journal: Airway hyperresponsiveness induced by intermittent hypoxia in rats. (Pubmed Central) - Feb 10, 2022
IH-induced AHR and lung inflammation were completely abolished by daily intraperitoneal injection of N-acetylcysteine (an antioxidant) or ibuprofen (a cyclooxygenase inhibitor), but not by apocynin (an inhibitor of NADPH oxidase) or vehicle. In conclusion, AHR and lung inflammation occur after 14-day IH exposure, with endogenous reactive oxygen species and cyclooxygenase metabolites being responsible for these responses.

|||||||||| meloxicam / Generic mfg., etoricoxib / Generic mfg.
Journal: The hyperthermic effect of central cholecystokinin is mediated by the cyclooxygenase-2 pathway. (Pubmed Central) - Feb 9, 2022
Finally, the CCK receptor antagonist YM022 (10 µg/kg; icv) attenuated the late phases of fever induced by bacterial lipopolysaccharide (10 µg/kg; intravenously). We conclude that centrally administered CCK causes hyperthermia through changes in the activity of "classical" thermoeffector pathways, and that the activation of COX-2 is required for the development of this response.

|||||||||| Journal, IO biomarker: A Cornflower Extract Containing N-Feruloylserotonin Reduces Inflammation in Human Skin by Neutralizing CCL17 and CCL22 and Inhibiting COX-2 and 5-LOX. (Pubmed Central) - Feb 8, 2022
The cornflower extract was shown to neutralize the two chemokines in vitro, inhibited COX-2 and 5-LOX, and demonstrated anti-inflammatory activities due mainly to the presence of N-feruloylserotonin. Although these findings would need to be confirmed in an in vivo study, the in vitro studies lay the foundation to explain the benefits of the cornflower extract when applied topically to individuals with atopic-prone skin.

|||||||||| Clinical, Review, Journal: Efficacy and safety of cyclooxygenase 2 inhibitors for desmoid tumor management: a systematic review. (Pubmed Central) - Feb 8, 2022
Three adverse effects were identified from the records of the six extracted studies. The strategy of watchful waiting using COX2 inhibitors with few side effects is weakly recommended for DF, especially DF patients with pain.

|||||||||| meloxicam / Generic mfg., piroxicam / Generic mfg.
Journal: Biological Evaluation and Molecular Docking Studies of Novel 1,3,4-Oxadiazole Derivatives of 4,6-Dimethyl-2-sulfanylpyridine-3-carboxamide. (Pubmed Central) - Feb 8, 2022
Furthermore, the results of cytotoxicity assay indicated that all of the tested compounds exhibited potent anti-cancer activity against A549, MCF-7, LoVo, and LoVo/Dx cell lines, compared with piroxicam and meloxicam. Moreover, our experimental study was supported by density functional theory (DFT) and molecular docking to describe the binding mode of new structures to cyclooxygenase.

|||||||||| celecoxib oral / Generic mfg.
Journal: Docking Study, Synthesis, and Anti-Inflammatory Potential of Some New Pyridopyrimidine-Derived Compounds. (Pubmed Central) - Feb 8, 2022
Moreover, the gastric ulcerogenic potential assay of compounds IIIf-h revealed their lower ulcerogenic liability than indomethacin with comparable effect to celecoxib. Virtual docking investigation of the most active candidates IIId, IIIf, IIIg and IIIi in the active site of COX-2 enzyme showed that these compounds implied interaction and binding motif similar to the cocrystallized ligand bromocelecoxib.

|||||||||| indomethacin / Generic mfg.
Preclinical, Journal: Design, synthesis, and in vitro antiplatelet aggregation activities of taiwanin C. (Pubmed Central) - Feb 8, 2022
These results demonstrate that taiwanin C acts very efficiently in two different signaling pathways of platelet aggregation. Although preliminary, these results indicate that taiwanin C has potential for further studies on its use for the development of new antiplatelet.

|||||||||| aspirin / Generic mfg., paracetamol / Generic mfg.
Prevalence Of Acetaminophen Intolerance Among Patients With Aspirin Exacerbated Respiratory Disease At A Tertiary Care Institution () - Feb 4, 2022 - Abstract #AAAAI2022AAAAI_2099;
Although preliminary, these results indicate that taiwanin C has potential for further studies on its use for the development of new antiplatelet. Acetaminophen intolerance should be assessed among AERD patients as it may signal the presence of more severe sinus disease and be a risk factor for recurrent sinus surgeries.

|||||||||| Journal: Automatic evaluation of cyclooxygenase 2 inhibition induced by metal-based anticancer compounds. (Pubmed Central) - Feb 3, 2022
The results obtained in this work provide significant information about the mechanism of the studied compounds, mostly ruthenium-based compounds, and the role of COX-2 in their mode of action. Moreover, this work confirmed the potential of the μSIA-LOV system as a simple, versatile, robust, and rapid analytical tool for automating the determination of IC values of metal-based compounds.

|||||||||| flurbiprofen / Generic mfg.
Preclinical, Journal: Akt / GSK3β / Nrf2 / HO-1 pathway activation by flurbiprofen protects the hippocampal neurons in a rat model of glutamate excitotoxicity. (Pubmed Central) - Feb 3, 2022
These findings suggest that FB has a neuroprotective effect in glutamate-induced excitotoxicity model through reduction of the glutamate excitotoxicity damage and activation of the survival pathway. These may occur due to modulation the survival pathway (Akt/GSK3β/Nrf2/HO-1) and inhibition of COX-2.

|||||||||| Clinical, Journal: Current practice of stress ulcer prophylaxis in a surgical patient cohort in a German university hospital. (Pubmed Central) - Feb 3, 2022
Still today, SUP is widely overused in non-ICU surgical patients. Information campaigns on risk factors for stress ulcer development and standard operating procedures for SUP are required to limit potential side effects and increased treatment costs.

|||||||||| montelukast / Generic mfg., etoricoxib / Generic mfg.
Preclinical, Journal: Effect of arachidonic acid cascade inhibitors on body temperature and cognitive functions in rats in the Morris water maze after acute cold injury. (Pubmed Central) - Feb 1, 2022
Montelukast tended to improve, etoricoxib and darbufelone mesylate did not improve cognitive functions of rats with CI. The results experimentally substantiate the possibility of effective pharmacoprophylaxis of CI and its negative effects on cognitive functions while applying arachidonic acid cascade inhibitors, particularly the non-selective COX inhibitor diclofenac sodium.

|||||||||| Vampex (carbenoxolone gel) / York Pharma
Preclinical, Journal: Involvement of Gap Junctions in Acetylcholine-Induced Endothelium-Derived Hyperpolarization-Type Dilation of Retinal Arterioles in Rats. (Pubmed Central) - Feb 1, 2022
Moreover, the retinal arteriolar response to ACh was attenuated by 18β-glycyrrhetinic acid under treatment with a combination of N-nitro-L-arginine methyl ester (a nitric oxide (NO) synthase inhibitor; 30 mg/kg) and indomethacin (a cyclooxygenase inhibitor; 5 mg/kg)...Treatment with 18β-glycyrrhetinic acid revealed no significant effect on NOR3 (an NO donor)-induced retinal vasodilator response. These results suggest that gap junctions contribute to the ACh-induced, EDH-type dilation of rat retinal arterioles in vivo.

|||||||||| Journal: Comparison of bioactive compounds and health promoting properties of fruits and leaves of apple, pear and quince. (Pubmed Central) - Jan 28, 2022
Leaves of apples and pears most effectively inhibited COX-1, COX-2, α-amylase, and α-glucosidase enzyme but quince leaves showed the most effective inhibition of pancreatic lipase, AChE and BuChE, 15-LOX, and antioxidant capacity, which particularly correlated with bioactive compounds. Present study shows that leaves are promising sources of valuable compounds and may be used to produce functional foods as well as for medical purposes.

|||||||||| Selective dietary plant extract as inhibitors of cyclooxygenase -1 and cyclooxygenase-2 activities (Zoom Room 1 (Virtual Room)) - Jan 28, 2022 - Abstract #ACSSp2022ACS_Sp_8086;
Selective inhibition of COX2 over COX1 were found to be better by minimizing gastrointestinal effects associated with COX-1. This study of screening of various food product as potential inhibitors against COX1 and CO2 is expected to guide us to develop effective natural dietary plant products that provide anti-inflammatory properties with limited or no side effects.

|||||||||| glibenclamide / Generic mfg., nifedipine immediate release / Generic mfg.
Preclinical, Journal: Mechanisms of inhibitory activity of root extract of Carpolobia lutea G. Don on in vitro contractile responses of rabbit corpus carvernosum. (Pubmed Central) - Jan 27, 2022
This study of screening of various food product as potential inhibitors against COX1 and CO2 is expected to guide us to develop effective natural dietary plant products that provide anti-inflammatory properties with limited or no side effects. Concentration-dependent relaxant effect of CLRE in rabbit CC involves the soluble guanylate cyclase/cyclase Guanosine Monophosphate system, and activation of ATP-dependent K channels.

|||||||||| Journal: Cytochrome c oxidase-modulatory near-infrared light penetration into the human brain: Implications for the noninvasive treatment of ischemia/reperfusion injury. (Pubmed Central) - Jan 27, 2022
We conclude that the transmission of 750 and 940 nm IRL through 4 cm of cadaver head supports the viability of IRL to treat human brain ischemia/reperfusion injury and is similar for skin with different skin pigmentation. We discuss experimental difficulties of working with fresh cadavers and strategies to overcome them as a guide for future studies.

|||||||||| temozolomide / Generic mfg.
Journal: N-2-(phenylamino) benzamide derivatives as novel anti-glioblastoma agents: Synthesis and biological evaluation. (Pubmed Central) - Jan 27, 2022
More importantly, I-1 showed higher safety than temozolomide and different mechanism from temozolomide in the C6 glioma orthotopic model. All the evidence demonstrated that N-2-(phenylamino) benzamide derivatives as novel anti-glioblastoma agents could be promising for the glioma management.

|||||||||| meloxicam / Generic mfg.
Journal: Synthesis, Spectroscopic and Biological Investigation of a New Ca(II) Complex of Meloxicam as Potential COX-2 Inhibitor. (Pubmed Central) - Jan 26, 2022
Moreover, Ca(II) complex significantly reduced the number of writhes induced by acetic acid (P < 0.05). The in silico molecular docking data revealed that Ca(II) complex obstructed COX-2 (dock score 6438) more effectively than COX-1 (dock score 5732) as compared to meloxicam alone.



	Diseases Companies Products Productz Mechanisms of Action Sites