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78 Companies | 115 Products |
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115 Products | |
266 Diseases | |
841 Trials |  |
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- | Journal: A new series of thiosemicarbazone-based anti-inflammatory agents exerting their action through cyclooxygenase inhibition. (Pubmed Central) - Sep 10, 2022
In silico pharmacokinetic studies suggest that compounds 2b and 2c possess favorable drug-likeness and oral bioavailability. It can be concluded that these compounds may act as orally bioavailable anti-inflammatory and antioxidant agents.
- | Retrospective data, Journal: "Use of sodium-glucose co-transporter 2 inhibitors, changes in body mass index and risk of fracture: a population-based cohort study". (Pubmed Central) - Sep 10, 2022
SGLT-2 inhibitor use was not associated with increased osteoporotic fracture risk, irrespective of change in BMI. However, a high cumulative dose could be an important risk factor.
- | Journal: Inhibiting peripheral and central MAO-B ameliorates joint inflammation and cognitive impairment in rheumatoid arthritis. (Pubmed Central) - Sep 10, 2022
Moreover, a newly developed reversible inhibitor of MAO-B ameliorated joint inflammation by inhibiting cyclooxygenase (Cox)-2. Therefore, MAO-B can be an effective therapeutic target for joint inflammation and cognitive impairment in patients with RA.
- | piceatannol / New York Medical College, Kyushu University
Preclinical, Journal: Mechanisms underlying the methylglyoxal-induced enhancement of uridine diphosphate-mediated contraction in rat femoral artery. (Pubmed Central) - Sep 10, 2022
Moreover, in the endothelium-denuded arteries, the Syk tyrosine kinase inhibitor piceatannol (10 M) suppressed the UDP-induced contraction. These results suggest that MGO augments UDP-induced contraction in rat femoral arteries and that this may be partly due to the alterations in the activities of Syk tyrosine kinase and p38 MAPK in the smooth muscle.
- | MitoQ (mitoquinone) / Antipodean
Journal: Increased COX-1 expression in benign prostate epithelial cells is triggered by mitochondrial dysfunction. (Pubmed Central) - Sep 3, 2022
COX-1 can be induced in benign prostate epithelial cells in response to mitochondrial complex I inhibition, and knockdown of the complex 1 protein NDUFS3. COX-1 and mitochondrial dysfunction may play more of a role than previously recognized in the development of age-related benign prostatic disease.
- | aspirin / Generic mfg.
Retrospective data, Journal, Checkpoint inhibition: Adding Cyclooxygenase Inhibitors to Immune Checkpoint Inhibitors Did Not Improve Outcomes in Metastatic Renal Cell Carcinoma. (Pubmed Central) - Sep 3, 2022
Among 188 included patients, 120 patients received either an NSAID or aspirin for at least three weeks during ICI therapies...Instead, the concurrent use of NSAIDs was associated with worse outcomes. Larger studies are needed to validate our observation.
- | Journal: Potential of Anti-inflammatory Molecules in the Chemoprevention of Breast Cancer. (Pubmed Central) - Sep 1, 2022
The merits of anti-inflammatory chemopreventive agents in prevention of cardiotoxicity have been described. We have also highlighted the ongoing research and advancements in improving the efficacy of using anti-inflammatory molecules as chemopreventive agents.
- | aspirin / Generic mfg.
Journal: Aspirin Ameliorates Pancreatic Inflammation and Fibrosis by Inhibiting COX-2 Expression in Experimental Chronic Pancreatitis. (Pubmed Central) - Aug 30, 2022
The therapeutic effect of ASA was also observed in caeruelin-induced CP. ASA has an ameliorating effect in murine models of CP through inhibition of pancreatic inflammation and fibrosis, which may be a promising option for clinical treatment.
- | indomethacin / Generic mfg.
Journal: AUGMENTED PROSTAGLANDIN E2 SIGNALING CAUSES PODOCYTE DAMAGE AND ALBUMINURIA-LIKE PHENOTYPE IN A ZEBRAFISH DISEASE MODEL OF GLOMERULAR HYPERFILTRATION. (Pubmed Central) - Aug 27, 2022
ASA has an ameliorating effect in murine models of CP through inhibition of pancreatic inflammation and fibrosis, which may be a promising option for clinical treatment. Our results support a role of augmented PGE2/EP2/EP4 signaling in the setting of glomerular hyperfiltration and albuminuria.
- | Journal: UPLC-ESI-QTRAP-MS/MS Analysis to Quantify Bioactive Compounds in Fennel (Foeniculum vulgare Mill.) Waste with Potential Anti-Inflammatory Activity. (Pubmed Central) - Aug 26, 2022
Phenolic acids and glycosylated flavonoids were quantified for their known possible anti-inflammatory activities; in fact, due to this reason their ability to inhibit COX-1 and COX-2 isoforms was evaluated through a fluorometric assay, resulting in specific inhibitors of COX-2 at certain concentrations. In conclusion, as the leaf of fennel may be beneficial to human health, clinical studies should include it in nutraceuticals or functional foods for human consumption.
- | ibuprofen / Generic mfg.
Journal: Randomized controlled trial of NSAID prior to cystoscopic ureteral stent removal in a pediatric population. (Pubmed Central) - Aug 24, 2022
In conclusion, as the leaf of fennel may be beneficial to human health, clinical studies should include it in nutraceuticals or functional foods for human consumption. Research to understand the etiology of pain after stent removal and techniques to minimize or prevent discomfort should continue in order to optimize patient outcomes.
- || Review, Journal: The Role of Resveratrol in Mild Cognitive Impairment and Alzheimer's Disease: A Systematic Review. (Pubmed Central) - Aug 24, 2022
Both anti-inflammatory and antioxidant effects can be related to preventing neurodegenerative diseases, doing maintenance, and enabling the recovery of these conditions directly related to inflammation and oxidative stress. We suggest that the use of RSV can bring beneficial effects to patients with MCI or AD.
- | paclitaxel / Generic mfg.
Journal: Neuroprotective Effect of Natural Compounds in Paclitaxel-Induced Chronic Inflammatory Pain. (Pubmed Central) - Aug 22, 2022
Hematoxylin and eosin (H and E) and immunohistochemistry (IHC) examinations confirmed that the medication reversed the abnormal alterations. The aforementioned natural substances inhibited cyclooxygenase-2 (COX-2), tumor necrosis factor-alpha (TNF-α), and nuclear factor kappa B (NF-κb) overexpression, as evidenced by enzyme-linked immunosorbant assay (ELISA) and Western blot and hence provide neuroprotection in chronic constriction damage.
- Perioperative Cyclooxygenase Inhibition And Post-operative Pancreatic Fistula After Pancreatoduodenectomy: A Systematic Review And Meta-analysis Of Comparative Studies (SDCC - 6A - Upper) - Aug 21, 2022 - Abstract #ACSCLINCON2022ACS_CLINCON_3130;
The aforementioned natural substances inhibited cyclooxygenase-2 (COX-2), tumor necrosis factor-alpha (TNF-α), and nuclear factor kappa B (NF-κb) overexpression, as evidenced by enzyme-linked immunosorbant assay (ELISA) and Western blot and hence provide neuroprotection in chronic constriction damage. NSAID use was not associated with increased morbidity, including POPF, and may reduce length of stay when implemented for multimodal pain control after PD.
- | Journal: The protective effects of NE 52-QQ57 against interleukin-33-induced inflammatory response in activated synovial mast cells. (Pubmed Central) - Aug 18, 2022
Mechanistically, NE 52-QQ57 mitigated IL-33-induced activation of the p38/nuclear factor-κB signaling pathway. We conclude that targeting GPR4 might be a promising strategy for RA treatment.
- | sulindac / Generic mfg.
Preclinical, Journal: Chemo-photodynamic Activity of Silicon Phthalocyanines Bearing Cyclooxygenase Inhibitors on Colorectal Cancer Cell Lines. (Pubmed Central) - Aug 18, 2022
In the present study, the anti-cancer activity of two different NSAIDs, sulindac- (Pc-1) or diclofenac-substituted (Pc-2) asymmetric silicon phthalocyanine derivatives, was evaluated in four different colorectal cancer cell lines bearing various carcinogenic mutations...In addition, the photophysical and photochemical properties of a synthesized Pc derivative bearing axial diclofenac and triethylene glycol groups (Pc-2) have been investigated, and the compound has been characterized by using different analytical techniques. Our results indicated that both compounds inhibit COX protein expression levels, activate apoptosis in all cell lines, and lead to cell cycle arrest in the G2/M phase, depending on the COX expression profiles of the cell lines, indicating that NSAIDs can be coupled with Pc's to achieve increased anti-cancer activity, especially on cancer cells known to have high COX activity.
- || Retrospective data, Review, Journal: Tocolytics for delaying preterm birth: a network meta-analysis (0924). (Pubmed Central) - Aug 18, 2022
Tocolytic drugs were associated with a range of adverse effects (from minor to potentially severe) compared with placebo or no tocolytic treatment, although betamimetics and combination tocolytics were more likely to result in cessation of treatment. The effects of tocolytic use on neonatal outcomes such as neonatal and perinatal mortality, and on safety outcomes such as maternal and neonatal infection were uncertain.
- | Journal: Anti-Inflammatory and Anti-oxidant Functions of Cornuside by Regulating NF-[Formula: see text] B, STAT-1, and Nrf2-HO-1 Pathways. (Pubmed Central) - Aug 14, 2022
The results indicated that CNS increased HO-1 expression, reduced LPS-activated NF-[Formula: see text]B-luciferase activity, and inhibited iNOS/NO and COX-2/PGE2, all of which contributed to the inhibition of STAT-1 phosphorylation. Thus, CNS can be a potential new substance for treating inflammatory disorders.
- | Journal: Structure-guided approach on the role of substitution on amide-linked bipyrazoles and its effect on their anti-inflammatory activity. (Pubmed Central) - Aug 12, 2022
In silico molecular dynamics simulations of the fluoro and methyl poses complexed with COX-2 for 50 ns indicated stable binding to COX-2. Generally, our approach delivers a fruitful matrix for the development of further amide-linked bipyrazole anti-inflammatory candidates.
- | aspirin / Generic mfg.
Journal: Risk factor management matters more than pharmaceutical cyclooxygenase-2 inhibition in the prevention of de novo intracranial aneurysms. (Pubmed Central) - Aug 10, 2022
Generally, our approach delivers a fruitful matrix for the development of further amide-linked bipyrazole anti-inflammatory candidates. For the prevention of de novo sIA formation, risk factor management with focus on cessation of smoking and treating hypertension adequately seems more important than pharmaceutical COX-2 inhibition.
- | aspirin / Generic mfg.
Journal: Aspirin protects against UVB-induced DNA damage through activation of AMP kinase. (Pubmed Central) - Aug 5, 2022
Unlike ASA, neither its immediate metabolite salicylate nor the COX inhibitor indomethacin reduced UVB-induced 8-OG or CPD in melanocyte Melan-a or keratinocyte HaCat cells in vitro...Finally, injection of Comp C partially reversed the protective effect of ASA on UVB-treated mouse skin in vivo. These studies suggest that ASA confers protection against UVB-induced DNA damage through activation of AMPK rather than COX inhibition.
- | meloxicam / Generic mfg., indomethacin / Generic mfg.
Journal: Effects of different cyclooxygenase inhibitors on prostaglandin E production, steroidogenesis and ovulation of bovine preovulatory follicles. (Pubmed Central) - Aug 4, 2022
This may contradict the generally accepted hypothesis that PGE is a key mediator of ovulation and progesterone production. Our results suggest a connection between ovarian disorders and inflammatory actions in early postpartum cows.
- || aspirin / Generic mfg.
Clinical, Journal: Plasma Metabolomics Analysis of Aspirin Treatment and Risk of Colorectal Adenomas. (Pubmed Central) - Aug 4, 2022
Metabolites whose levels increased with 81 mg/day aspirin treatment and were also associated with decreased risk of adenomas during follow-up included certain forms of lysophosphotidylcholine (LysoPC) and lysophosphotidylethanolamine (LysoPE) as well as trihydroxyoctadecenoic acid (TriHOME), which is a derivative of linoleic acid and is upstream of cyclooxygenase inhibition by aspirin in the linoleate and arachidonic acid metabolism pathways. In conclusion, our findings regarding lysophospholipids and metabolites in the linoleate metabolism pathway may provide novel insights into the chemopreventive effects of aspirin in the colorectum, although they should be considered hypothesis-generating at this time.
- | metamizole / Generic mfg.
Journal: Metamizole-Associated Risks in Decompensated Hepatic Cirrhosis. (Pubmed Central) - Aug 2, 2022
In conclusion, our findings regarding lysophospholipids and metabolites in the linoleate metabolism pathway may provide novel insights into the chemopreventive effects of aspirin in the colorectum, although they should be considered hypothesis-generating at this time. Metamizole therapy, especially at high doses, should only be used with a high level of caution in patients with decompensated cirrhosis.
- | Journal: Antibacterial and Anti-inflammatory Activity of Extracts and Major Constituents Derived from Stachytarpheta indica Linn. Leaves and Their Potential Implications for Wound Healing. (Pubmed Central) - Jul 30, 2022
Plant extracts (6.25-100 μg/mL) and individual compounds (3.125-50 μg/mL) elicited strong anti-inflammatory effects by suppressing the expression of interleukin-8 and inhibiting cyclooxygenase-1 and 5-lipoxygenase enzymes. Collectively, these results indicate that plant extracts and isolated compounds derived from S. indica have the potential to inhibit bacterial growth, promote tissue regeneration and reduce inflammation, hence, potentially providing the basis for a novel therapeutic for the treatment of wounds.
- | Journal: Design, Synthesis and Evaluation of Benzimidazole Hybrids to Inhibit Acetylcholinesterase and COX for Treatment of Alzheimer's Disease. (Pubmed Central) - Jul 29, 2022
Collectively, these results indicate that plant extracts and isolated compounds derived from S. indica have the potential to inhibit bacterial growth, promote tissue regeneration and reduce inflammation, hence, potentially providing the basis for a novel therapeutic for the treatment of wounds. The findings indicate that Benzimidazole hybrids utilizing ibuprofen and pyrrolidine moiety may prove a useful template for the development of new chemical moieties against AD with multiple potencies.
- capecitabine / Generic mfg., sorafenib / Generic mfg., celecoxib oral / Generic mfg.
Prophylactic strategies for hand-foot syndrome/skin reaction associated with systemic cancer treatment: A meta-analysis of randomized controlled trials (Poster Area, Hall 4) - Jul 28, 2022 - Abstract #ESMO2022ESMO_2565;
Studies investigating optimal dosing for celecoxib and urea cream are recommended. There is inadequate evidence to make recommendations regarding pyridoxine.
- | aspirin / Generic mfg.
Biomarker, Journal, Tumor microenvironment, IO biomarker: Salicylic acid-based hypoxia-responsive chemodynamic nanomedicines boost antitumor immunotherapy by modulating immunosuppressive tumor microenvironment. (Pubmed Central) - Jul 28, 2022
Meanwhile, as a class of inhibitors of COX-2/PGE, the potential mechanism of aspirin or 5-aminosalicylic acid has been a mystery in tumor therapy and chemoprevention. To expand the application of aspirin family nanomedicine in biomedicine, herein, we firstly developed a hypoxia-sensitive Fe-5,5'-azosalicylic acid nanoscale coordination polymer nanomedicines via a "old drugs new tricks" strategy for synergistic chemodynamic therapy and remodulation of immunosuppressive tumor microenvironment to elevate antitumor immunotherapy effect.
- | sirolimus / Generic mfg.
Preclinical, Journal: Influences of Rapamycin on Retinal Ganglion Cells in Rats with Acute High Intraocular Pressure Through Regulating COX-2. (Pubmed Central) - Jul 27, 2022
Compared with that in the normal group, the content of IL-6 and TNF-α was elevated in the other two groups and their content in the rapamycin group was lower. Rapamycin inhibits COX-2 to repress inflammation and apoptosis, thereby exerting a protective effect on the retinal ganglion cells in rats with acute high intraocular pressure.
- | mefenamic acid / Generic mfg.
Journal: Carboranyl Analogues of Mefenamic Acid and Their Biological Evaluation. (Pubmed Central) - Jul 27, 2022
The ortho-, meta-, and para-carborane derivatives were synthesized in three steps: halogenation of the respective cluster, followed by a Pd-catalyzed B-N coupling and hydrolysis of the nitrile derivatives under acidic conditions. The COX inhibitory activity and cytotoxicity for different cancer cell lines revealed that the carborane analogues have stronger antitumor potential compared to their parent organic compound.
- | Journal: A New EGFR Inhibitor from Ficus benghalensis Exerted Potential Anti-Inflammatory Activity via Akt/PI3K Pathway Inhibition. (Pubmed Central) - Jul 26, 2022
Furthermore, the molecular docking study proposed the potential direct binding of FAG with EGFR with a high affinity. This study showed that FAG is a natural EGFR inhibitor, NO-releasing, and COX-inhibiting anti-inflammatory agent via EGFR/Akt/PI3K pathway inhibition.
- | Preclinical, Journal: LiuweiDihuang improved cognitive functions in SAMP8 mice by inhibiting COX-2 expression and subsequent neuroinflammation. (Pubmed Central) - Jul 23, 2022
This study showed that FAG is a natural EGFR inhibitor, NO-releasing, and COX-inhibiting anti-inflammatory agent via EGFR/Akt/PI3K pathway inhibition. Taken together, the present data not only indicated that LW is an effective agent on improving the learning and memory deficits through mitigating neuroinflammation but highlighted the LW can be a potential therapeutic drug for AD therapy.
- | Journal: Discovery of a Redox-Activatable Chemical Probe for Detection of Cyclooxygenase-2 in Cells and Animals. (Pubmed Central) - Jul 20, 2022
FQ exhibits high circulation half-life and metabolic stability sufficient for target site accumulation and demonstrates COX-2-targeted uptake and retention in cancer cells and pathologic tissues. Once taken up, it undergoes redox-mediated transformation into a fluorescent compound fluorocoxib Q-H that results in high signal-to-noise contrast and differentiates pathologic tissues from non-pathologic tissues for real-time in vivo imaging.
- | Journal: Stimuli-responsive prodrug of non-steroidal anti-inflammatory drug diclofenac: self-immolative drug release with turn-on near-infrared fluorescence. (Pubmed Central) - Jul 16, 2022
The non-toxic prodrug exhibited turn-on red fluorescence with endogenous ROS in cancer cells and inhibited COX-2 expression in the inflammation-induced macrophage cells. The prodrug strategy thus would be helpful for the controlled fluorogenic delivery of DCF for inflammatory diseases.
- || Review, Journal: Resolution-promoting autacoids demonstrate promising cardioprotective effects against heart diseases. (Pubmed Central) - Jul 15, 2022
This review discussed (I) the preclinical and clinical evidence of inflammation-resolution in cardiac disorders including atrial fibrillation; (II) how and why many traditional antiinflammatory treatments failed to prevent or cure cardiac inflammation and fibrosis; and (III) whether new therapeutic strategies may interact with the resolution machinery to have cardioprotective effects. RvD D-series resolving, RvE E-series resolving, LXA4 lipoxin A4, MaR1 maresin-1.
- | Journal: Dyhidro-β-agarofurans natural and synthetic as acetylcholinesterase and COX inhibitors: interaction with the peripheral anionic site (AChE-PAS), and anti-inflammatory potentials. (Pubmed Central) - Jul 12, 2022
The molecular docking, and the propidium displacement assay suggested that the compounds do not bind to the active site of the enzyme AChE, but rather bind to the peripheral anionic site (PAS) of the enzyme, on the other hand, the natural compound 8, showed the best inhibitory activity on the COX-2 enzyme with an IC value of 0.04 ± 0.007 µM. The pharmacokinetic profile calculated in silico using the SWISSADME platform shows that these molecules could be considered as potential drugs for the treatment of neurodegenerative diseases such as AD.
- | aspirin / Generic mfg., celecoxib oral / Generic mfg.
Preclinical, Journal: Whole-body PET imaging in humans shows that C-PS13 is selective for cyclooxygenase-1 and can measure the in vivo potency of nonsteroidal anti-inflammatory drugs. (Pubmed Central) - Jul 10, 2022
C-PS13 selectively binds to COX-1 in humans and can measure the in vivo potency of NSAIDs that competitively inhibit arachidonic acid binding to COX-1. These in vivo studies, which reflect the net effect of drug absorption and metabolism in all organs of the body, demonstrated that ketoprofen had unexpectedly high potency, that celecoxib substantially inhibited COX-1, and that aspirin acetylation of COX-1 did not block binding of the representative non-steroidal inhibitor C-PS13.
- || Review, Journal: Neuroaxonal and cellular damage/protection by prostanoid receptor ligands, fatty acid derivatives and associated enzyme inhibitors. (Pubmed Central) - Jul 10, 2022
Several classes of prostaglandins are implicated (or are considered beneficial) in certain central nervous system dysfunctions (e.g., Alzheimer's, Parkinson's, and Huntington's diseases; amyotrophic lateral sclerosis and multiple sclerosis; stroke, traumatic brain injuries and pain) and in ocular disorders (e.g., ocular hypertension and glaucoma; allergy and inflammation; edematous retinal disorders). This review endeavors to address the physiological/pathological roles of prostaglandins in the central nervous system and ocular function in health and disease, and provides insights towards the therapeutic utility of some prostaglandin agonists and antagonists, polyunsaturated fatty acids, and cyclooxygenase inhibitors.
- | Journal, HEOR: Drug utilization, clinical and economic outcomes of patients with osteoarthritis of the hip and/or knee treated with long-term use of traditional NSAIDs, topical NSAIDs, and COX-2 inhibitors. (Pubmed Central) - Jul 9, 2022
Analyses characterize the long-term real-world utilization of NSAIDs and associated outcomes for patients with OA of the hip and/or knee. Study results highlight the likelihood of switching and risk of negative clinical outcomes associated with long-term use.
- | indomethacin / Generic mfg.
Journal: Novel benzofurane-pyrazole derivatives with anti-inflammatory, cyclooxygenase inhibitory and cytotoxicity evaluation. (Pubmed Central) - Jul 6, 2022
This activity was found close to indomethacin COX-2 inhibition measured as 7.4 μM IC...Only compound was the 4, which showed a low inhibition on IL-6 levels. Cell viability was up to 60% at 100 μM for all compounds (1-9) on RAW 264.7 and NIH3T3 cell lines, thus compounds were reported to be noncytotoxic.
- | cimetidine / Generic mfg., ibuprofen / Generic mfg.
Preclinical, Journal, IO biomarker: Cimetidine and Ibuprofen Modulate T Cell Responses in a Mouse Model of Breast Cancer. (Pubmed Central) - Jul 6, 2022
Cimetidine and ibuprofen correct some effector T cell-related parameters in cancerous mice. Immunotherapeutic potentials cimetidine and ibuprofen in cancers need investigations.
- | Journal: Prostaglandin 2α Promotes Autophagy and Mitochondrial Energy Production in Fish Hepatocytes. (Pubmed Central) - Jul 2, 2022
Moreover, PGF2α enhanced mitochondrial accumulation and ATP production, and increased the transcript levels of β-oxidation- and mitochondrial respiratory chain-related genes. Collectively, these findings demonstrate that the COX pathway is implicated in lipid degradation induced by energy deprivation, and that PGF2α is a key molecule triggering autophagy, lipolysis, and mitochondrial development in zebrafish hepatocytes.
- | Preclinical, Journal: Delta-9-tetrahydrocannabinol increases vascular endothelial growth factor (VEGF) secretion through a cyclooxygenase-dependent mechanism in rat granulosa cells. (Pubmed Central) - Jul 1, 2022
Alterations in granulosa cell function, such as the ones observed after THC exposure, may impact essential ovarian processes including folliculogenesis and ovulation, which could in turn affect female reproductive health and fertility. With the ongoing increase in cannabis use and potency, further study on the impact of cannabis and its constituents on female reproductive health is required.
- | ketorolac / Generic mfg.
Journal: Ketorolac tromethamine represses senescence in aging articular chondrocytes. (Pubmed Central) - Jun 29, 2022
Lastly, the inhibitory effects of ketorolac tromethamine on the activation of β-galactosidase and the upregulation of p21 and p53 were greatly abolished by the overexpression of COX-2. Collectively, ketorolac tromethamine repressed cellular senescence in aging articular chondrocytes by inhibiting COX-2.
- || Preclinical, Review: Antidepressant Effects of NSAIDs in Rodent Models of Depression-A Systematic Review. (Pubmed Central) - Jun 28, 2022
When comparing the different classes of NSAIDs, selective COX-2 inhibitors were shown to provide the most stable antidepressant effect compared to non-selective COX-inhibitors. Suggested mechanisms behind the antidepressant effects were attenuation of neuroinflammation, HPA-axis dysregulation and altered monoamine expression.
- || Review, Journal: Recent development on COX-2 inhibitors as promising anti-inflammatory agents: The past 10 years. (Pubmed Central) - Jun 28, 2022
In this review, we highlight the various structural classes of organic and natural scaffolds with efficient COX-2 inhibitory activity reported during 2011-2021. It will be valuable for pharmaceutical scientists to read up on the current chemicals to pave the way for subsequent research.
- THE COX-2/PGE2 PATHWAY AS AN INDEPENDENT IMMUNE CHECKPOINT (Poster Area) - Jun 28, 2022 - Abstract #EACR2022EACR_616;
Altogether, these data reveal an essential role of IFN-γ signalling and effector NK/cDC1/T cell axis in orchestrating the therapeutic benefit of combining inhibitors of COX-2/PGE2 pathway with ICIs. Conclusion PGE2 signalling via EP2/EP4 receptors on tumour infiltrating leucocytes represents a readily targetable independent immune checkpoint to increase the efficacy of currently approved immunotherapies.
- | Journal: Fluorochrome Selection for Imaging Intraoperative Ovarian Cancer Probes. (Pubmed Central) - Jun 25, 2022
Fluorescent probes RR11 and 23 (MSA14), were used for preliminary near-infrared (NIR) fluorescent imaging (FLI) in human ovarian cancer (OVCAR-3 and SKOV-3) xenograft models. Surprisingly, a tumor-specific signal was observed for both tested fluorescent probes, even though this signal is not linked to the presence of COX-1.
- Tavalisse (fostamatinib) / Rigel, Kissei
P2Y receptor antagonists and tyrosine kinase inhibitors reduce oxLDL-mediated procoagulant platelet activity (Exhibition) - Jun 25, 2022 - Abstract #ISTH2022ISTH_2726;
Our study further demonstrates that CD36 signaling from oxLDL activation overlaps with the GPVI signaling pathway, in such that the phosphorylation of proteins along the Syk-BTK-PI3K/Akt axis is enhanced. P2Y antagonists (e.g., ticagrelor), BTK inhibitors (e.g., ibrutinib), and Syk inhibitors (e.g.
- || Review, Journal: Acute kidney injury associated with non-steroidal anti-inflammatory drugs. (Pubmed Central) - Jun 24, 2022
AKI from NSAIDs is usually reversible with favorable prognosis after discontinuation of NSAIDs. Avoidance of NSAIDs exposure is extremely important, especially among high-risk patients.