COX inhib News - LARVOL Sigma

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|||||||||| Preclinical, Journal: Synthesis and In Vitro Biological Evaluation of p-Carborane-Based Di-tert-butylphenol Analogs. (Pubmed Central) - Jun 14, 2023
Interestingly, R-830-Cb did not affect the viability of primary cells and suppressed HCT116 cell proliferation more potently than its carbon-based R-830 counterpart. Considering all the advantages of boron cluster incorporation for enhancement of drug biostability, selectivity, and availability of drugs, R-830-Cb can be tested in further mechanistic and in vivo studies.

|||||||||| Journal: The Anti-Acne Potential and Chemical Composition of Knautia drymeia Heuff. and Knautia macedonica Griseb Extracts. (Pubmed Central) - Jun 14, 2023
Moreover, they had the most favorable low minimal inhibitory concentration values against acne strains, and importantly, they were non-toxic toward normal skin fibroblasts. In conclusion, K. drymeia extracts seem to be promising and safe agents for further biomedical applications.

|||||||||| Journal: Alterations of pain pathways by experimental sleep disturbances in humans: Central pain-inhibitory, cyclooxygenase, and endocannabinoid pathways. (Pubmed Central) - Jun 14, 2023
P=N/A
In conclusion, K. drymeia extracts seem to be promising and safe agents for further biomedical applications. These findings suggest that central pain-inhibitory and COX mechanisms through which sleep disturbances may contribute to chronic pain risk are sex specific, implicating the need for sex-differential therapeutic targets to effectively reduce chronic pain associated with sleep disturbances in both sexes.

|||||||||| aspirin / Generic mfg.
Non-steroid anti-inflammatory treatment enhances the efficacy of modulated electro hyperthermia on triple negative breast cancer and melanoma cancer models in vivo (Poster and Exhibition Hall) - Jun 13, 2023 - Abstract #EACR2023EACR_798;
Similarly, in the B16F10 melanoma model, lungs nodules were significantly less in mice treated with mEHT + Aspirin.ConclusionNSAIDs effectively enhance the mEHT anti-tumor effect in TNBC and melanoma cancer models; they increase tumor destruction, where apoptosis may play a role. Disecting the exact molecular mechanisms further is under our current investigation.

|||||||||| AM 095 / BMS
Preclinical, Journal: TXA2 mediates LPA1-stimulated uterine contraction in late pregnant mouse. (Pubmed Central) - Jun 12, 2023
Moreover, selective thromboxane receptor (TP) antagonist, SQ-29548, and Rho kinase inhibitor, Y-27632 almost eliminated LPA-induced uterine contractions. LPA1 stimulation elicits contractions in the late pregnant mouse uterus using the contractile prostanoid, TXA2 and may be targeted to induce labor in uterine dysfunctions/ dystocia.

|||||||||| celecoxib oral / Generic mfg.
Journal, Adverse events: Plasma and hepatic exposures of celecoxib and diclofenac prescribed alone in patients with cytochrome P450 2C9*3 modeled after virtual oral administrations and likely associated with adverse drug events reported in a Japanese database. (Pubmed Central) - Jun 2, 2023
The in vivo and in vitro fractions of the victim drug metabolized by a specific polymorphic P450 form is an important determining factor for estimating drug-drug interactions. Virtual hepatic and plasma exposures estimated by pharmacokinetic modeling in patients harboring the impaired CYP2C9*3 allele could represent a causal factor for adverse events induced by celecoxib or diclofenac in a manner similar to that for drug interactions.

|||||||||| simvastatin / Generic mfg.
Journal: New insights on mode of action of vasorelaxant activity of simvastatin. (Pubmed Central) - Jun 1, 2023
Furthermore, simvastatin was found to attenuate the release of calcium (Ca) from intracellular stores in the presence of ruthenium red (ryanodine receptor, RyR inhibitor) and extracellular stores via nifedipine (voltage-operated Ca channels, VOCC blocker) and SK&F96365 (receptor-operated Ca channel, ROCC blocker). Thus, it can be concluded that the vasorelaxant effect of simvastatin involves NO/cGMP pathways, ATR receptors, Ca channels, and K channels.

|||||||||| Review, Journal: Design and Development of COX-II Inhibitors: Current Scenario and Future Perspective. (Pubmed Central) - May 30, 2023
To address this gap, herein we present an overview of chemical structures and inhibitory activity of different scaffolds of known COX-II inhibitors. The insights from this article could be helpful in seeding the development of next-generation COX-II inhibitors.

|||||||||| indomethacin / Generic mfg., captopril / Generic mfg.
Preclinical, Journal: Pulegone Prevents Hypertension through Activation of Muscarinic Receptors and Cyclooxygenase Pathway in L-NAME-Induced Hypertensive Rats. (Pubmed Central) - May 26, 2023
Secondly, the mechanism involved in hypotensive activity was determined in the presence of pharmacological drugs such as atropine/muscarinic receptor blocker (1?mg/kg), L-NAME/NOS inhibitor (20?mg/kg), and indomethacin/COX inhibitor (5?mg/kg) in anesthetized rats...Rats were divided into six groups which were treated orally with tween 80 (placebo), captopril (10?mg/kg), and different doses of pulegone (20?mg/kg, 40?mg/kg, and 80?mg/kg)...Plasma mRNA expression of eNOS was reduced, whereas ACE, ICAM1, and EDN1 levels were high in the L-NAME group, which was facilitated by pulegone treatment. To conclude, pulegone prevented L-NAME-induced hypertension by demonstrating a hypotensive effect through muscarinic receptors and cyclooxygenase pathway, indicating its use as a potential candidate in managing hypertension.

|||||||||| rofecoxib (TRM-201) / Tremeau Pharma
Journal: Discovery of andrographolide hit analog as a potent cyclooxygenase-2 inhibitor through consensus MD-simulation, electrostatic potential energy simulation and ligand efficiency metrics. (Pubmed Central) - May 24, 2023
In this study, chemical and bio-informatics approaches have been employed to find a novel potent andrographolide (AGP) analog as a COX-2 inhibitor having better pharmacological properties than aspirin and rofecoxib (controls). In-depth analysis revealed that AGP analog A3 (3-[2-[(1R,4aR,5R,6R,8aR)-6-hydroxy-5,6,8a-trimethyl-2-methylidene-3,4,4a,5,7,8-hexahydro-1H-naphthalen-1-yl]ethylidene]-4-hydroxyoxolan-2-one) forms the most stable complex with the AF-COX-2 showing the least RMSD value (0.37?

|||||||||| Journal: Hybrids of carbonic anhydrase and cyclooxygenase inhibitors attenuate cardiac hypoxic inflammatory injuries. (Pubmed Central) - May 22, 2023
By inhibiting the activity of overexpressed CA under hypoxia, the acidic microenvironment can be regulated to inhibit the hypoxic injury, in which the pH-dependent primary drug resistance can be overcome to improve the anti-inflammatory effect of the COX inhibitor. Consequently, this study provides a new strategy for the treatment of cardiac inflammation accompanied by hypoxia.

|||||||||| Journal: Bergapten alleviates depression-like behavior by inhibiting cyclooxygenase 2 activity and NF-?B/MAPK signaling pathway in microglia. (Pubmed Central) - May 22, 2023
Mechanistically, we found that BG directly inhibited cyclooxygenase 2 (COX2) activity, and suppressed nuclear factor-?B (NF-?B) and mitogen-activated protein kinase (MAPK) signaling pathways in microglia. Together, these results highlight the important role of BG in microglial activation, neuroinflammation, and depression-like behavior, thus providing a new candidate drug for depression treatment.

|||||||||| STUDY OF ADVERSE REACTIONS TO COVID-19 VACCINATION IN PATIENTS WITH RHEUMATIC DISEASES () - May 19, 2023 - Abstract #EULAR2023EULAR_4167;
Based on the results of this study, we believe that adverse reactions to vaccination are acceptable. We plan to accumulate more cases and analyze them in the future.The exacerbation of disease after the first vaccination would predict the exacerbation after the second vaccination.

|||||||||| Journal: Microbial Transformation of the Sesquiterpene Lactone, Vulgarin, by Aspergillus niger. (Pubmed Central) - May 17, 2023
unsaturated carbonyl group in (1) for better COX-2 inhibitory activity. On the other hand, the selectivity of (1) as COX-1 inhibitor may be enhanced via the reduction of C-1 carbonyl group.

|||||||||| Preclinical, Journal: Hybrid Analogues of Hydrazone and Phthalimide: Design, Synthesis, In vivo, In vitro, and In silico Evaluation as Analgesic Agents. (Pubmed Central) - May 17, 2023
On the other hand, the selectivity of (1) as COX-1 inhibitor may be enhanced via the reduction of C-1 carbonyl group. High therapeutic index of these ligands is one of the valuable advantages of these compounds.

|||||||||| Journal: Serum zinc deficiency could be associated with dementia conversion in Parkinson's disease. (Pubmed Central) - May 14, 2023
Zn deficiency also contributed to a shorter time to dementia conversion (HR 0.953, 95% CI 0.919 to 0.988, p?<?0.01). This clinical study suggests that a low serum Zn level can be a risk factor for developing PD-D and could be used as a biological marker for PD-D conversion.

|||||||||| aspirin / Generic mfg.
High rates of high on-aspirin platelet reactivity in patients after transcatheter aortic valve implantation (Station 4) - May 13, 2023 - Abstract #ESC2023ESC_2332;
In this exploratory study, HAPR was not significantly associated with the occurrence of HALT. Further studies are required to evaluate the long-term risk of leaflet thrombosis or thromboembolic events in patients with HAPR.

|||||||||| Bradycardic effect of endothelial-specific bradykinin type-II receptors overexpression in mice: impact on blood pressure. (Station 8) - May 13, 2023 - Abstract #ESC2023ESC_1345;
SBP reduction is not dependent on two major vascular pathways stimulated by products of NOS and COX but appears to be related to endothelial B2R-dependent HR reduction. Hence, agonism at B2R could be a valuable target for development of new cardiovascular drugs.

|||||||||| Preclinical, Journal: Carborane-based Tebufelone Analogs and their Biological Evaluation In Vitro. (Pubmed Central) - May 9, 2023
Cell viability studies on HT29 colon adenocarcinoma cells revealed that the observed antiproliferative effect of the para-carborane analogs of tebufelone is enhanced by structural modifications that include chain elongation in combination with introduction of a methylene spacer resulting in higher anticancer activity compared to tebufelone. Hence, this strategy proved to be a promising approach to design potent 5-LO inhibitors with potential application as cytostatic agents.

|||||||||| Journal: Synthesis and biological evaluation of benzamide-chalcone hybrids as potential c-Met (Pubmed Central) - May 8, 2023
Compounds 7h, 7i, 7j, 8f, and 8j were evaluated for the serum protein binding, using the in vitro bovine serum albumin binding assay. The results indicated that the tested compounds bind to bovine serum albumin (BSA) and can be further explored by other studies.

|||||||||| Retrospective data, Review, Journal: Non-selective NSAIDs do not increase retear rates post-arthroscopic rotator cuff repair: A meta-analysis. (Pubmed Central) - May 7, 2023
The results indicated that the tested compounds bind to bovine serum albumin (BSA) and can be further explored by other studies. NSAIDs use in post-arthroscopic rotator cuff repair pain relief does not increase retear rates and can provide similar clinical outcomes compared to a non-NSAID regime.

|||||||||| capecitabine / Generic mfg.
Topical diclofenac in prevention of capecitabine-associated HFS in patients with GI cancers: An exploratory subgroup analysis of the D-ToRCH study (Poster HALL LEVEL 0) - May 6, 2023 - Abstract #ESMOGI2023ESMO_GI_447;
Applying topical diclofenac led to less frequent capecitabine dose reductions. This is the first study which convincingly established the role of a topical COX inhibitor for HFS prevention.

|||||||||| Review, Journal: Antiplatelet drugs: Potential therapeutic options for the management of neurodegenerative diseases. (Pubmed Central) - May 3, 2023
Apart from this, the review also emphasizes the recent developments of selected natural antiplatelet phytochemicals belonging to key classes of plant-based bioactive compounds, including polyphenols, alkaloids, terpenoids, and flavonoids as potential therapeutic candidates in NDDs. We believe that the broad analysis of contemporary strategies and specific approaches for plausible therapeutic treatment for NDDs presented in this review could be helpful for further successful research in this area.

|||||||||| aspirin / Generic mfg.
Journal: Molecular Ultrasound Imaging Depicts the Modulation of Tumor Angiogenesis by Acetylsalicylic Acid. (Pubmed Central) - May 2, 2023
Molecular US demonstrated an inhibitory effect of ASA on VEGFR-2 expression accompanied by a tendency towards lower vessel density. Thus, this study suggests the inhibition of angiogenesis via VEGFR-2 downregulation as one of the anti-tumor effects of ASA.

|||||||||| glibenclamide / Generic mfg., indomethacin / Generic mfg.
Preclinical, Journal: Vasorelaxant Effect of Moroccan Cannabis sativa Threshing Residues on Rat Mesenteric Arterial Bed is Endothelium and Muscarinic Receptors Dependent. (Pubmed Central) - May 1, 2023
Chemical investigation of EFCS identified potential active components namely apigenin and derivatives of luteolin skeleton and also additional components such as neophytadiene, squalene, and ?-sitosterol. In conclusion, the vasorelaxant effect of EFCS on rat mesenteric arterial bed, which is dependent of muscarinic receptor activation, nitric oxide, and EDHF, can account for potential therapeutic use against high blood pressure related cardiovascular diseases.

|||||||||| Journal: Synthesis and Anti-Inflammatory Activity of the Natural Cyclooxygenase-2 Inhibitor Axinelline A and Its Analogues. (Pubmed Central) - May 1, 2023
and reduced production of PGE, NO, and ROS. The potent in vitro anti-inflammatory activity of A1, together with its lack of cytotoxicity, makes it an attractive candidate for a new anti-inflammatory lead.

|||||||||| Review, Journal: PDE5 inhibitors and gastric mucosa: implications for the management of peptic ulcer disease. (Pubmed Central) - Apr 29, 2023
In recent years, studies have mentioned tremendous pleiotropic effects of PDE5 inhibitors on gastrointestinal, urogenital, musculoskeletal, reproductive, cutaneous, and neurologic disorders. Recent data shows that PDE5 inhibition augments gastric mucosa protection, and here, we review the most recent findings regarding the use of PDE5 inhibitors for the prevention and management of PUD.

|||||||||| clarithromycin / Generic mfg., celecoxib oral / Generic mfg.
Preclinical, Journal: Promising anti-Helicobacter pylori and anti-inflammatory metabolites from unused parts of Phoenix dactylifera CV 'Zaghloul': in (Pubmed Central) - Apr 28, 2023
The anti-inflammatory response of isolated compounds was evaluated by inhibiting cyclooxygenase-2 enzyme using TMPD Assay followed by an in silico study to validate their mechanism of action using celecoxib as a standard drug...These results were verified by molecular docking studies, where 4, 7 and 8 showed the best interactions with key amino acid residues of COX-2 active site. The present study characterizes a new sesquiterpene lactone and recommends 4 and 8 for future in

|||||||||| celecoxib oral / Generic mfg.
Preclinical, Journal: Celecoxib, a Non-Steroidal Anti-Inflammatory Drug, Exerts a Toxic Effect on Human Melanoma Cells Grown as 2D and 3D Cell Cultures. (Pubmed Central) - Apr 28, 2023
When celecoxib was tested on 3D melanoma cell cultures, the drug exerted an inhibitory effect on cell outgrowth from spheroids and reduced the invasiveness of melanoma cell spheroids into the hydrogel matrix. This work suggests that celecoxib could represent a new potential therapeutic approach in melanoma therapy.

|||||||||| nimesulide / Generic mfg.
Journal: Synergistic Combination of Citrus Flavanones as Strong Antioxidant and COX-Inhibitor Agent. (Pubmed Central) - Apr 28, 2023
Indeed, DFM proves to be the most powerful anti-inflammatory and antioxidant agent reducing, synergistically and in a statistically significant manner (p < 0.05), PGE2 release than the oxidative stress markers, also with respect to the nimesulide and trolox used as reference compounds. This leads to the hypothesis that FM could be an excellent antioxidant and COX inhibitor candidate to counteract intestinal inflammation.

|||||||||| ketorolac / Generic mfg.
Journal, Reflex: Effect of Cyclooxygenase Inhibition on Peripheral Venous Distension Reflex in Healthy Humans. (Pubmed Central) - Apr 26, 2023
The presented data show that cyclooxygenase blockade attenuates the responses in MSNA and blood pressure to peripheral venous distension reflex. The results suggest that cyclooxygenase products play a key role in evoking afferent activation responsible for the venous distension reflex.

|||||||||| aspirin / Generic mfg.
Journal: Influence of aspirin on aging skeletal muscle: Insights from a cross-sectional cohort of septuagenarians. (Pubmed Central) - Apr 24, 2023
These cross sectional data suggest that chronic aspirin consumption does not influence age-related skeletal muscle atrophy, but does influence skeletal muscle composition in septuagenarians. Prospective longitudinal investigations remain necessary to better understand the influence of chronic COX regulation on aging skeletal muscle health.

|||||||||| Preclinical, Journal: Novel, Brain-Permeable, Cross-Species Benzothiazole Inhibitors of Microsomal Prostaglandin E Synthase-1 (mPGES-1) Dampen Neuroinflammation In Vitro and In Vivo. (Pubmed Central) - Apr 21, 2023
We found that our compound significantly suppressed proinflammatory cytokines and chemokines in the hippocampus but not in the kidney. Taken together, we demonstrated the potential of UT-11 in treating neuroinflammatory conditions, including epilepsy and stroke, and warrant further optimization.

|||||||||| ticagrelor / Generic mfg., aspirin / Generic mfg., ibrutinib / Generic mfg.
Journal: Effect of antiplatelet agents and tyrosine kinase inhibitors on oxLDL-mediated procoagulant platelet activity. (Pubmed Central) - Apr 17, 2023
Studies of washed human platelets, as well as platelets from mouse and non-human primate models of hyperlipidemia, further determined that P2YR antagonists (e.g., ticagrelor) and BTK inhibitors (e.g., ibrutinib) reduced oxLDL-mediated platelet responses and procoagulant activity, whereas COX inhibitors (e.g., aspirin) had no significant effect. Together, our results demonstrate that oxLDL enhances GPVI-mediated platelet procoagulant activity in a manner that may be more effectively reduced by P2YR antagonists and tyrosine kinase inhibitors compared to COX inhibitors.

|||||||||| Review, Journal, Surgery: Can Anti-inflammatory Drugs used in Plastic Surgery Procedures Increase the Risk of Hematoma? (Pubmed Central) - Apr 5, 2023
Together, our results demonstrate that oxLDL enhances GPVI-mediated platelet procoagulant activity in a manner that may be more effectively reduced by P2YR antagonists and tyrosine kinase inhibitors compared to COX inhibitors. Based on available data, there is no significant risk of hematoma with use of anti-inflammatory drugs in plastic surgery.

|||||||||| aspirin / Generic mfg., ibuprofen / Generic mfg.
Journal: Non-steroidal anti-inflammatory drugs as a targeted therapy for bone marrow failure in Ghosal Hematodiaphyseal Dysplasia. (Pubmed Central) - Apr 3, 2023
Mass spectrometry analysis demonstrated that urinary PG metabolites were increased along with proinflammatory lipoxygenase (LOX) products 5-Hydroxyeicosatetraenoic acid and leukotriene E4. Our data show that NSAIDs at standard doses surprisingly reduced both COX and LOX products, leading to the resolution of cytopenias, and should be considered for first-line treatment for Ghosal syndrome.

|||||||||| aspirin / Generic mfg., paracetamol / Generic mfg., ibuprofen / Generic mfg.
Preclinical, Journal: The influence of cyclooxygenase inhibitors on kynurenic acid production in rat kidney: a novel path for kidney protection? (Pubmed Central) - Mar 31, 2023
Our data show that NSAIDs at standard doses surprisingly reduced both COX and LOX products, leading to the resolution of cytopenias, and should be considered for first-line treatment for Ghosal syndrome. Our study provides novel mechanisms of COX inhibitors action in the kidney, with possible implications for the treatment of kidney diseases.

|||||||||| indomethacin / Generic mfg.
Preclinical, Journal: Cuminaldehyde Effects in a MIA-Induced Experimental Model Osteoarthritis in Rat Knees. (Pubmed Central) - Mar 30, 2023
Cuminaldehyde was found to be as effective as indomethacin in reducing pain in all evaluated tests, including forced walking, functional disability of weight distribution on the legs, and spontaneous pain in animals with osteoarthritis...Its nociceptive activity occurs via central and peripheral mechanisms. Cuminaldehyde modulates the immune response of the inflammatory process and may be considered a leading compound for the development of new anti-inflammatory and analgesic drugs.

|||||||||| paracetamol / Generic mfg.
Clinical, Journal: Combination Pharmacotherapy for Patent Ductus Arteriosus: Rationale and Evidence. (Pubmed Central) - Mar 27, 2023
Combination therapy with acetaminophen and ibuprofen is a novel strategy for PDA treatment in ELGANs, as it may facilitate higher ductal closure rates via additive action on two separate pathways inhibiting prostaglandin production...In this review, we examine the potential clinical impact of treatment failure in ELGANs with significant PDA, highlight the biological rationale in support of studying combination therapy, and review the randomized and non-randomized studies to date. With the rising number of ELGANs receiving neonatal intensive care, who are vulnerable to PDA-related morbidities, there is an urgent need for adequately powered clinical trials to systematically investigate the efficacy and safety of combination therapy for PDA treatment.

|||||||||| Journal: Glycolipid-enriched fraction of Osmanthus fragrans inhibits LPS-induced expression of inflammatory genes, COX-2, E-selectin, and Interleukin-8. (Pubmed Central) - Mar 27, 2023
Taken together, the results demonstrate the anti-inflammatory potential of O. fragrans flower extracts in general, and of the glycolipid-enriched fraction in particular. The effects of glycolipid-enriched fraction are potentially mediated via the inhibition of the TLR4 receptor complex.

|||||||||| Review, Journal: Sex-differences in prostaglandin signaling: a semi-systematic review and characterization of PTGDS expression in human sensory neurons. (Pubmed Central) - Mar 25, 2023
Our semi-systematic literature review reveals a need for continued inclusivity of both male and female animals in prostaglandins studies and data analysis separated by sex in preclinical and clinical studies. Our finding of sex-differences in neuronal PTGDS expression in humans exemplifies the need for a more comprehensive understanding of how the prostaglandin system functions in the DRG in rodents and humans.

|||||||||| Anaphylactic Shock With Ketorolac-rare Case (Walter E. Washington Convention Center, Area G, Hall C (Lower Level)) - Mar 25, 2023 - Abstract #ATS2023ATS_6107;
He was treated in ER for gastroenteritis with ondansetron, Pepcid and IV fluids and Ketorolac 15 mg IV for pain...He was given Benadryl, dexamethasone, 2L IVF, 0.5mg of IM epinephrine... Ketorolac anaphylactic shock is rare but life threatening and must be considered in all who receives it.

|||||||||| indomethacin / Generic mfg., ibuprofen / Generic mfg.
Retrospective data, Review, Journal: Association between endotypes of prematurity and pharmacological closure of patent ductus arteriosus: A systematic review and meta-analysis. (Pubmed Central) - Mar 21, 2023
Our data suggest that the pathologic condition that triggers prematurity may alter the response to pharmacological treatment of PDA. The DA of infants exposed to HDP appears to be more responsive to COX inhibitors.

|||||||||| ibuprofen / Generic mfg.
Journal: Expectant Management or Early Ibuprofen for Patent Ductus Arteriosus. (Pubmed Central) - Mar 20, 2023
P=N/A
Expectant management for PDA in extremely premature infants was noninferior to early ibuprofen treatment with respect to necrotizing enterocolitis, bronchopulmonary dysplasia, or death at 36 weeks' postmenstrual age. (Funded by the Netherlands Organization for Health Research and Development and the Belgian Health Care Knowledge Center; BeNeDuctus ClinicalTrials.gov number, NCT02884219; EudraCT number, 2017-001376-28.).

|||||||||| setanaxib (GKT831) / Calliditas
Journal: Food Restriction Augmented Alpha1-Adrenergic Mediated Contraction in Mesenteric Arteries. (Pubmed Central) - Mar 20, 2023
Augmentation of ?1-adrenergic-mediated contraction via the inhibition of the eNOS-NO pathway increased the activation of ROS through NOX2/4 in response to FR. Reduced eNOS-NO signaling may be a pathophysiological counterbalance to prevent hypovolemic shock in response to FR.

|||||||||| Clinical, Preclinical, Journal: Disconnect between COX-2 selective inhibition and cardiovascular risk in preclinical models. (Pubmed Central) - Mar 16, 2023
In addition, the vascular ring model suggested possible adverse cardiovascular effects by COX-2 inhibitors, although these effects were not seen in vivo studies. These results may also suggest that COX-2 inhibition alone is not responsible for rofecoxib-mediated adverse cardiovascular outcomes.

|||||||||| Journal: Exploring the Chemical Constituents, Antioxidant, Xanthine Oxidase and COX Inhibitory Activity of Commiphora gileadensis Commonly Grown Wild in Saudi Arabia. (Pubmed Central) - Mar 16, 2023
LC-MS analysis revealed the presence of phenolic compounds such as caffeic acid phenyl ester, hesperetin, hesperidin, chrysin and transient amounts of catechin, gallic acid, rutin and caffeic acid. The chemical constituents of this plant can be explored further to investigate its wide variety of therapeutic potential.

|||||||||| metformin / Generic mfg., bleomycin / Generic mfg.
Review, Journal, IO biomarker: Chemoprevention of oral cancer: A review and future perspectives. (Pubmed Central) - Mar 15, 2023
In the era of personalized medicine, future studies will focus on identifying specific biomarkers and molecular profile to monitor and to prevent malignant transformation. Larger trials are warranted to validate the effect of chemopreventive agents.

|||||||||| aspirin / Generic mfg.
Journal: Effects of intravenous lysine acetylsalicylate versus oral aspirin on platelet responsiveness in patients with ST-segment elevation myocardial infarction: the ECCLIPSE-STEMI trial. (Pubmed Central) - Mar 15, 2023
P2/3
The administration of intravenous LA resulted in a significantly reduction of platelet reactivity compared to oral aspirin on ticagrelor inhibited platelets in patients with STEMI. Loading dose of LA achieves an earlier platelet inhibition, and with less variability than aspirin.Trial Registration: Unique identifier: NCT02929888; URL: http://www.clinicaltrials.gov.

|||||||||| Clinical: See IWK's new publication in @JAMANetworkOpen! "Evaluation of Health-Related Values and Preferences of Adults Who Were Preterm Infants and Parents of Preterm Infants Concerning Use of Prophylactic Cyclooxygenase Inhibitor Drugs" @souvik_neo @DrMCampbellYeo https://t.co/MxkQQcQZaa (Twitter) - Mar 15, 2023



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