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17 Companies | 12 Products |
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12 Products | |
36 Diseases | |
50 Trials |  |
5676 News |  |
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- | dexmedetomidine / Generic mfg.
Preclinical, Journal: Dexmedetomidine Attenuates Total Body Radiation-Induced Acute Liver Injury in Mice Through the Nrf2/HO-1 Pathway. (Pubmed Central) - Aug 22, 2022
Dex exhibits a protective effect on reducing acute radiation-induced liver injury and oxidative stress, and the mechanism may be associated with the activation of Nrf2/HO-1 pathways.
- | 4SC 301 / 4SC
Journal: Protective effects of three flavonoids from Dendrobium huoshanense flowers on alcohol-induced hepatocyte injury via activating Nrf2 and inhibiting NF-κB pathways. (Pubmed Central) - Aug 22, 2022
Flavonoids 1 - 3 could also reduce the phosphorylation levels of I κ B α and NF- κ B p65 of alcohol-induced L02 cells, while SC75741 (NF- κ B inhibitor) could not enhance the inhibitory effects of 1 - 3 on alcohol-induced L02 cells injury. The data above indicated that flavonoids 1 - 3 could inhibit alcohol-induced hepatocyte injury, which might be attributed to alleviating oxidative stress and mitigating inflammatory response by activating Nrf2 and inhibiting NF- κ B pathways.
- | selenomethionine (SLM) / University of Iowa, Holden Comprehensive Cancer Center
Journal: Selenomethionine protected BMECs from inflammatory injury and oxidative damage induced by Klebsiella pneumoniae by inhibiting the NF-κB and activating the Nrf2 signaling pathway. (Pubmed Central) - Aug 22, 2022
Moreover, the protein and gene expression levels of Nrf2, NQO-1 and HO-1 were upregulated, and the nuclear expression of Nrf2 protein was also promoted, which enhanced the activity of antioxidant enzymes. In conclusion, SeMet protected BMECs from inflammatory injury and oxidative stress induced by K. pneumoniae by inhibiting the NF-κB and activating the Nrf2 signaling pathway.
- || Review, Journal: An Overview of NRF2-Activating Compounds Bearing α,β-Unsaturated Moiety and Their Antioxidant Effects. (Pubmed Central) - Aug 22, 2022
This review provides an overview of the reaction mechanism of α,β-unsaturated moiety-bearing compounds with the NRF2/KEAP1 complex, their pharmacological properties, structural activity-relationship and their effect on antioxidant and anti-inflammatory responses. As the first of its kind, this review article offers collective and comprehensive information on NRF2-activators containing α,β-unsaturated moiety with the aim of broadening their therapeutic prospects in a wide range of oxidative stress-related diseases.
- | Journal: Anti-Inflammatory Effects of Auranamide and Patriscabratine-Mechanisms and In Silico Studies. (Pubmed Central) - Aug 22, 2022
The possible molecular targets of NRF2 activation by these two compounds were predicted using molecular docking studies and it was found that the compounds might inhibit the Kelch domain of KEAP1 and GSK-3β activity. The physicochemical and drug-like properties of the test compounds were predicted using Schrodinger small molecule drug discovery suite (v.2022-2).
- | chlorogenic acid / Jiuzhang Biotech
Journal: Chlorogenic Acid, the Main Antioxidant in Coffee, Reduces Radiation-Induced Apoptosis and DNA Damage via NF-E2-Related Factor 2 (Nrf2) Activation in Hepatocellular Carcinoma. (Pubmed Central) - Aug 22, 2022
The knockdown of Nrf2 reversed CGA-mediated radiation resistance in HCC cells. In conclusion, CGA might be a potential tumor-protective compound upon irradiation and reduce the efficacy of radiotherapy via ROS scavenging and Nrf2 activation.
- | Journal: Insufficient S-adenosylhomocysteine hydrolase compromises the beneficial effect of diabetic BMSCs on diabetic cardiomyopathy. (Pubmed Central) - Aug 22, 2022
SAHH overexpression in diabetic BMSCs significantly rescued cellular function partly via activating Nrf2/HO-1 signal. Transplantation of diabetic BMSCs with SAHH overexpression improved angiogenesis and cardiac adverse remodeling in rats.
- | losartan / Generic mfg.
Preclinical, Journal: Ginsenoside Re attenuates memory impairments in aged Klotho deficient mice via interactive modulations of angiotensin II AT1 receptor, Nrf2 and GPx-1 gene. (Pubmed Central) - Aug 18, 2022
Both GRe and the AT1 receptor antagonist losartan failed to attenuate the decrease in phosphorylation of JAK2/STAT3 in aged Klotho deficient (±) mice but significantly activated nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated signaling...Both the GPx inhibitor mercaptosuccinate and Nrf2 inhibitor brusatol counteracted the effects of GRe on all neurobehavioral impairments in aged Klotho deficient (±) mice. Our results suggest that GRe attenuates all alterations, such as AT1 receptor expression, NOX-, ROS-, and GPx-levels, and cognitive dysfunction in aged Klotho deficient (±) mice via upregulation of Nrf2/GPx-1/ERK/CREB signaling.
- | Journal: Nrf2 as a regulator of mitochondrial function: Energy metabolism and beyond. (Pubmed Central) - Aug 18, 2022
We focus on Nrf2 involvement in promoting mitochondrial quality control and regulation of basic aspects of mitochondrial function, including energy production, reactive oxygen species generation, calcium signalling, and cell death induction. Given the importance of mitochondria in the development of multiple diseases, these findings reinforce the pharmacological activation of Nrf2 as an attractive strategy to counteract mitochondrial dysfunction.
- | Preclinical, Journal: Curcumin activates Nrf2/HO-1 signaling to relieve diabetic cardiomyopathy injury by reducing ROS in vitro and in vivo. (Pubmed Central) - Aug 18, 2022
Surprisingly, we found that the activation of the Nrf2 signaling pathway significantly increased cardiomyocyte viability, reduced ROS formation, increased antioxidant enzyme activity, and inhibited cardiomyocyte apoptosis. In conclusion, these findings conclusively infer that CUR activation of the Nrf2/HO-1 signaling pathway exerts myocardial protection by reducing ROS formation.
- | Preclinical, Journal: Evaluation of Hepatoprotective Effects of Piperlongumine Derivative PL 1-3-Loaded Albumin Nanoparticles on Lipopolysaccharide/d-Galactosamine-Induced Acute Liver Injury in Mice. (Pubmed Central) - Aug 18, 2022
1-3 NPs treatment can inhibit inflammation, oxidative stress, and apoptosis via the downregulation of NF-κB signaling pathways, the activation of Nrf2/HO-1 signaling pathways, and the inhibition of expression of Bax and caspase 3 proteins. The above results demonstrated that PL 1-3-loaded bovine serum albumin nanoparticles possessed potential value in intervention of inflammation-based liver injury.
- | Journal: 6'-O-Galloylpaeoniflorin attenuates Helicobacter pylori-associated gastritis via modulating Nrf2 pathway. (Pubmed Central) - Aug 17, 2022
The anti-inflammatory and antioxidant effects of GPF on H. pylori-infected cells were attenuated by an Nrf2 inhibitor. Taken together, these data suggest that GPF reduces H. pylori-induced gastric mucosa injury by activating Nrf2 signaling and that GPF is a potential candidate for the treatment of H. pylori-associated gastritis.
- | SP600125 / BMS
Preclinical, Journal: Carveol ameliorates mercury-induced oxidative stress, neuroinflammation, and neurodegeneration in a mouse brain. (Pubmed Central) - Aug 14, 2022
Taken together, these data suggest that GPF reduces H. pylori-induced gastric mucosa injury by activating Nrf2 signaling and that GPF is a potential candidate for the treatment of H. pylori-associated gastritis. Our findings indicate that carveol can inhibit the p-JNK pathway, thereby inhibiting HgCl2-induced apoptosis and downregulating the expression of inflammatory mediators.
- || Review, Journal: A mechanistic review on immunomodulatory effects of selective type two cannabinoid receptor β-caryophyllene. (Pubmed Central) - Aug 14, 2022
Previous results indicated that the antioxidant effects of β-caryophyllene were suggested through different pathways, including activation of nuclear factor erythroid 2-related factor-2 (Nrf2)/heme oxygenase-1 (HO-1)/antioxidant axis and inhibition of the HMG-CoA reductase activity, and oxidative stress biomarkers levels. Furthermore, various results showed immunomodulatory effects of BCP through inhibiting microglial cells, CD and CD T lymphocytes, modulated Th /T immune balance through the activation of the CB receptor, and reducing mitogen-activated protein kinases (p38MAPK) and NF-kB activation and increased ionized calcium-binding adaptor molecule-1 (Iba-1) and IL-1β.
- | cisplatin / Generic mfg.
Journal: Quercetin Mitigates Cisplatin-Induced Oxidative Damage and Apoptosis in Cardiomyocytes through Nrf2/HO-1 Signaling Pathway. (Pubmed Central) - Aug 14, 2022
In conclusion, this study reports that quercetin has the potential to antagonize cisplatin-caused cardiotoxicity by reducing ROS-mediated mitochondrial damage and inflammation via the Nrf2/HO-1 and p38MAPK/NF-[Formula: see text]Bp65/IL-8 signaling pathway. This study provided the theoretical basis and experimental proof for the clinical application of quercetin as a new effective strategy to relieve chemotherapy-induced cardiotoxicity.
- | Preclinical, Journal: Nano-Selenium Alleviates Cadmium-Induced Acute Hepatic Toxicity by Decreasing Oxidative Stress and Activating the Nrf2 Pathway in Male Kunming Mice. (Pubmed Central) - Aug 14, 2022
In addition, the NSe group significantly increased mRNA expressions of Nrf2 pathway related molecules (Nrf2, HO-1, NQO-1, GST, GSH-Px, CAT and SOD) compared to the Cd group (P < 0.05). In conclusion, NSe shows its potentiality to reduce Cd-induced liver injury by inhibiting oxidative stress and activating the Nrf2 pathway.
- | Preclinical, Journal, IO biomarker: Chicoric acid attenuates tumor necrosis factor-α-induced inflammation and apoptosis via the Nrf2/HO-1, PI3K/AKT and NF-κB signaling pathways in C28/I2 cells and ameliorates the progression of osteoarthritis in a rat model. (Pubmed Central) - Aug 13, 2022
In vivo experiments also proved the therapeutic effects of CA on OA in rats. These findings indicate that CA may become a new drug for the treatment of OA.
- | dimethyl fumarate / Generic mfg.
Preclinical, Journal: ERK1 loss accelerates the progression of osteoarthritis in aged mice via NRF2/BACH1 signaling. (Pubmed Central) - Aug 13, 2022
Above all, we confirmed the effects of ERK1 on the progression of OA and clarified the mechanisms underlying these effects. DMF might has significant use in the development of novel drugs for the therapy of OA in the future.
- | Journal: Protective effect of Smilax excelsa L. pretreatment via antioxidant, anti-inflammatory effects, and activation of Nrf-2/HO-1 pathway in testicular torsion model. (Pubmed Central) - Aug 12, 2022
When the histological examinations of the tissues were evaluated, it was found that morphological structure of the tissues was retained in the treatment group. The findings indicate that SE prevents tissue damage in the torsion model by antioxidant and anti-inflammatory effects and activating Nrf-2/HO-1 pathway.
- || PK/PD data, Review, Journal: Isobavachalcone: A comprehensive review of its plant sources, pharmacokinetics, toxicity, pharmacological activities and related molecular mechanisms. (Pubmed Central) - Aug 12, 2022
IBC can inhibit the NF-κB pathway and the production of multiple inflammatory mediators by activating NRF2/HO-1 pathway, thus producing anti-inflammatory effects. Moreover, we discussed the limitations of current research on IBC and put forward some new perspectives and challenges, which provide a strong basis for clinical application and new drug development of IBC in the future.
- | Journal: Corylin from Psoralea fructus (Psoralea corylifolia L.) protects against UV-induced skin aging by activating Nrf2 defense mechanisms. (Pubmed Central) - Aug 12, 2022
Thus, Nrf2 activation might be a therapeutic target for preventing skin aging or skin diseases caused by aging. Our findings also provided evidence that warrants the further investigation of plant ingredients to facilitate the discovery of novel therapies targeting skin aging.
- | Journal: Genetic alterations of Keap1 confers chemotherapeutic resistance through functional activation of Nrf2 and Notch pathway in head and neck squamous cell carcinoma. (Pubmed Central) - Aug 11, 2022
Our findings suggest that Keap1 mutations define a distinct disease phenotype and the Keap1-Nrf2 pathway is one of the leading molecular mechanisms for clinical chemotherapeutic resistance. Targeting this pathway may provide a potential and attractive personalized treatment strategy for overcoming chemotherapeutic resistance conferred by Keap1 mutations.
- Sanbexin (edaravone dexborneol) / Simcere
Edaravone Dexborneol Protects Against Cerebral Ischemia/Reperfusion -Induced Blood-Brain Barrier Dysfunction by Inhibiting Ferroptosis via Activation of Nrf-2/HO-1/GPX4 Signaling (Zone 1, Science and Technology Hall, Level 200) - Aug 11, 2022 - Abstract #AHA2022AHA_3913;
Targeting this pathway may provide a potential and attractive personalized treatment strategy for overcoming chemotherapeutic resistance conferred by Keap1 mutations. Abstract is embargoed at this time.
- Skyclarys (omaveloxolone) / Reata
Nrf2 Agonist Omaveloxolone Improves Cardiac Function in Mice With Friedreich's Ataxia (Moderated Posters 2) - Aug 11, 2022 - Abstract #AHA2022AHA_2346;
Abstract is embargoed at this time. This is the first study to demonstrate sexual dimorphism in FA hearts and show that OMAV can improve cardiac function in FA mice with severe cardiomyopathy.
- Klotho Attenuates UVB-induced skin injuries by Concomitantly Activating Nrf2 and Brg1 (e-Poster Hall) - Aug 11, 2022 - Abstract #EADV2022EADV_2475;
- Oxidative Damage is a Hallmark of Atopic Dermatitis in Humans and Mice (Room 1) - Aug 11, 2022 - Abstract #ESDR2022ESDR_22;
Both features are aggravated by additional loss of Nrf2, suggesting a role of oxidative stress in the phenotype. Together, these results identify a potential role of an impaired Nrf2-mediated oxidative stress response in chronic skin inflammation, which could be therapeutically explored in AD patients.
- | Trial initiation date: Testing the Effect of the Broccoli Seed and Sprout Extract, Avmacol ES, on the Cancer Causing Substances of Tobacco in Heavy Smokers (clinicaltrials.gov) - Aug 11, 2022
P2, N=120, Not yet recruiting, Sponsor: National Cancer Institute (NCI)
Together, these results identify a potential role of an impaired Nrf2-mediated oxidative stress response in chronic skin inflammation, which could be therapeutically explored in AD patients. Initiation date: Aug 2022 --> Jan 2023
- | Journal: (9S,13R)-12-oxo-phytodienoic acid attenuates inflammation by inhibiting mPGES-1 and modulating macrophage polarization via NF-κB and Nrf2/HO-1 pathways. (Pubmed Central) - Aug 11, 2022
Moreover, AA-24 selectively inhibited mPGES-1 and reduced inflamed paw edema in carrageenan-induced mice. In conclusion, AA-24 attenuates inflammation by inhibiting mPGES-1 and modulating macrophage polarization via the NF-κB and Nrf2/HO-1 pathways and could be a promising candidate for developing anti-inflammatory drug.
- || Review, Journal: Flexion of Nrf2 by tea phytochemicals: A review on the chemopreventive and chemotherapeutic implications. (Pubmed Central) - Aug 11, 2022
Tea catechins show their dual Nrf2-modulatory effect by directly acting on Nrf2-Keap1 or their upstream regulators and downstream effectors in a highly case-specific manner. In this review, we have tried to present a comprehensive evaluation of the Nrf2-mediated chemopreventive and chemotherapeutic applications of tea in various preclinical cancer models, the Nrf2-modulatory mechanisms, and the limitations which need to be addressed in future research.
- | Journal: Protective effects of fraxin on cerebral ischemia-reperfusion injury by mediating neuroinflammation and oxidative stress through PPAR-γ/NF-κB pathway. (Pubmed Central) - Aug 11, 2022
In this review, we have tried to present a comprehensive evaluation of the Nrf2-mediated chemopreventive and chemotherapeutic applications of tea in various preclinical cancer models, the Nrf2-modulatory mechanisms, and the limitations which need to be addressed in future research. Fraxin could considerably ameliorate cerebral I/R damage by repressing oxidative stress, inflammatory response, and cell apoptosis through abrogating the PPARγ/ NF-κB pathway.
- | Preclinical, Journal: Rosmarinic acid relieves LPS-induced sickness and depressive-like behaviors in mice by activating the BDNF/Nrf2 signaling and autophagy pathway. (Pubmed Central) - Aug 11, 2022
Taken together, our research found that RA could effectively alleviate sickness behaviors and nerve injury caused by neuroinflammation, and its protective effects were mediated by the Nrf2 signaling pathway, which reduced cellular oxidative stress, inflammation, mitochondrial respiratory function damage, and autophagy imbalance. Therefore, RA has the potential to prevent or treat sickness and depressive-like behaviors under conditions of neuroinflammation.
- | paracetamol / Generic mfg.
Journal: Sarmentosin promotes USP17 and regulates Nrf2-mediated mitophagy and cellular oxidative stress to alleviate APAP-induced acute liver failure. (Pubmed Central) - Aug 11, 2022
Therefore, RA has the potential to prevent or treat sickness and depressive-like behaviors under conditions of neuroinflammation. In summary, our research revealed that sarmentosin could alleviate APAP-induced liver acute injury through USP17-mediated Nrf2 overexpression and PINK1-dependent mitophagy.
- | Xalkori (crizotinib) / Pfizer
Journal: MgIG exerts therapeutic effects on crizotinib-induced hepatotoxicity by limiting ROS-mediated autophagy and pyroptosis. (Pubmed Central) - Aug 11, 2022
In conclusion, CRIZO promoted autophagy activation and pyroptosis via the accumulation of ROS in HL-7702 cells. MgIG exerts therapeutic effects on CRIZO-induced hepatotoxicity by decreasing the level of ROS.
- | dexamethasone / Generic mfg.
Journal: Nrf2 signaling activation by a small molecule activator compound 16 inhibits hydrogen peroxide-induced oxidative injury and death in osteoblasts. (Pubmed Central) - Aug 11, 2022
Dexamethasone- and nicotine-caused oxidative stress and death in osteoblasts were attenuated by Cpd16 as well...Importantly, weekly Cpd16 administration largely ameliorated trabecular bone loss in ovariectomy mice. Together, Cpd16 alleviates HO-induced oxidative stress and death in osteoblasts by activating Nrf2 cascade.
- | Journal: Forsythoside B attenuates neuro-inflammation and neuronal apoptosis by inhibition of NF-κB and p38-MAPK signaling pathways through activating Nrf2 post spinal cord injury. (Pubmed Central) - Aug 10, 2022
FTS•B effectively attenuates neuro-inflammation and secondary neuronal apoptosis by inhibition of NF-κB and p38-MAPK signaling pathways through activating Nrf2 after SCI. This study demonstrates FTS•B to be a potential therapeutic for SCI.
- | cisplatin / Generic mfg.
Journal: Dioscin ameliorates cisplatin-induced intestinal toxicity by mitigating oxidative stress and inflammation. (Pubmed Central) - Aug 10, 2022
Meanwhile, dioscin potently promoted Wnt3A/β-catenin signaling to relieve cisplatin-induced proliferation inhibition. In conclusion, our study suggests that dioscin could ameliorate the cisplatin-induced intestinal toxicity by reducing oxidative stress and inflammation.
- | Journal: (±)-5-bromo-2-(5-fluoro-1-hydroxyamyl) Benzoate Protects Against Oxidative Stress Injury in PC12 Cells Exposed to HO Through Activation of Nrf2 Pathway. (Pubmed Central) - Aug 10, 2022
The inhibitory effect of BFB on oxidative stress may be partially regulated by Nrf2 activation, and the initiation and induction of autophagy. BFB inhibited HO-induced oxidative stress injury in PC12 cells by activating the Nrf2 pathway, initiating and inducing autophagy, suggesting that BFB may be a promising therapeutic agent in treating neurological disorders like cerebral ischemia.
- | Journal: Therapeutic effects of total saikosaponins from Radix bupleuri against Alzheimer's disease. (Pubmed Central) - Aug 10, 2022
Collectively, these data shows that TS may serve as a potential approach for AD treatment. Further investigation is needed to clarify the detailed mechanisms underlying TS regulating gut microbiota and oxidative stress.
- | Preclinical, Journal: The Anti-Parkinson Potential of Gingko biloba-Supplement Mitigates Cortico-Cerebellar Degeneration and Neuropathobiological Alterations via Inflammatory and Apoptotic Mediators in Mice. (Pubmed Central) - Aug 10, 2022
Also, the loss of cortico-cerebellar neurons was attenuated, marked by increase in dendritic spine length and width with numerous viable neurons. Overall findings suggest that Gb-S could be a potential pharmacotherapeutic candidate providing a strong protection for cortico-cerebellar neurocellular substances and against Parkinsonism-like non-motor and motor symptoms.
- | selenomethionine (SLM) / University of Iowa, Holden Comprehensive Cancer Center
Preclinical, Journal: SeMet attenuates AFB1-induced intestinal injury in rabbits by activating the Nrf2 pathway. (Pubmed Central) - Aug 10, 2022
The aim of this study was to investigate the role of selenomethionine (SeMet) in alleviating AFB1 induced intestinal injury by inhibiting intestinal oxidative stress...SeMet pretreatment significantly improved the performance of the rabbits, alleviated intestinal oxidative stress and the inflammatory response. Therefore, we confirmed that SeMet protects against AFB1 induced oxidative damage and improves productivity in rabbits by activating the Nrf2/HO-1 signaling pathway.
- | Journal: The Neuroprotective Effect of GM-1 Ganglioside on the Amyloid-Beta-Induced Oxidative Stress in PC-12 Cells Mediated by Nrf-2/ARE Signaling Pathway. (Pubmed Central) - Aug 10, 2022
Consistently, knock-down of Nrf-2 via siRNA abolished the beneficial decrease of Aβ-induced oxidative stress by GM-1 treatment, indicating that GM-1-improved oxidative stress was regulated by the Nrf-2 signaling pathway. Collectively, GM-1 could alleviate Aβ-induced oxidative damage mediated through the Nrf-2/ARE signaling pathway, which might be a potential agent for AD treatment.
- | Journal: Arbutin-modified microspheres prevent osteoarthritis progression by mobilizing local anti-inflammatory and antioxidant responses. (Pubmed Central) - Aug 10, 2022
Intra-articular use of GM-Lipo@ARB can effectively reduce inflammation and oxidative stress in the articular cartilage and thus, attenuating OA progression in a mouse model. The study proposed a novel ARB-laden functional microsphere, GM-Lipo@ARB, and demonstrated that this compound may be used as an alternative therapeutics for treating OA.
- Development of protein-like polymer therapeutics for modulating the Nrf2/Keap1 protein-protein interaction | Poster Board #2871 (Hall F2 (McCormick Place Convention Center)) - Aug 9, 2022 - Abstract #ACSFall2022ACS_Fall_12924;
In summary, we successfully synthesized and characterized a novel biomaterial capable of overcoming the current challenges facing peptide therapeutics by achieving cellular uptake, enhanced binding affinity, and demonstrated bioactivity. This work is a step forward in the development of methods for direct inhibition of intracellular PPIs and has potential for clinical translation.
- Q-Force (quercetin) / Quercegen, Temple University
Roles of MAPK and Nrf2 signaling pathways in quercetin alleviating redox imbalance induced by hydrogen peroxide in mammary epithelial cells (Virtual-only (Zoom)) - Aug 9, 2022 - Abstract #ACSFall2022ACS_Fall_11007;
Moreover, the inhibitors of MAPK and Nrf2 pathways reduced the protective effects of quercetin on cell viability, the activity of CAT and the expression of GCLM. In summary, the protective effect of quercetin in mammary epithelial cells was mediated via MAPK and Nrf2 pathways.
- allopurinol / Generic mfg.
Role of nuclear factor erythroid 2-related factor 2 and aldo-keto reductases in the metabolic activation of 1-nitropyrene in human lung cells (A549 and HBEC3-KT) (Regency A (Hyatt Regency McCormick Place)) - Aug 9, 2022 - Abstract #ACSFall2022ACS_Fall_7366;
Inhibitors of POR, NQO1, and XO, 2-chloroethyl ethyl sulfide (200 µM), dicoumarol (10 µM), and allopurinol (40 µM), respectively, failed to modify 1-AP production relative to control in both cell lines, suggesting the lack of involvement of POR, NQO1, and XO in 1-NP nitroreduction under aerobic conditions. Together, these data show the relevance of AKR1C1-1C3 and NRF2 in the metabolic activation of the lung carcinogen.
- Synthesis of non-electrophilic, NRF2-activating prodrugs | Poster Board #3471 (Hall F2 (McCormick Place Convention Center)) - Aug 9, 2022 - Abstract #ACSFall2022ACS_Fall_3432;
In an effort to increase cell permeability and lipophilicity of the compound, we have synthesized a series of PRL-295 prodrugs and bioisosteres, which will replace the carboxylic moiety of the original compound. With further testing, we hope to demonstrate improved pharmacological activity.
- | Journal: tert-Butylhydroquinone-induced formation of high-molecular-weight p62: A novel mechanism in the activation of Nrf2-Keap1. (Pubmed Central) - Aug 7, 2022
These results demonstrate that the Nrf2-Keap1 pathway is partially regulated by p62. tBHQ-induced HMW-p62 production may be a novel mechanism in the activation of the Nrf2-Keap1-ARE pathway.
- || Review, Journal: GSK-3β-mediated regulation of Nrf2/HO-1 signaling as a new therapeutic approach in the treatment of movement disorders. (Pubmed Central) - Aug 7, 2022
In addition to that it highlights various GSK-3β inhibitors and the Nrf2/HO-1 activators, which exert robust neuroprotection against motor disorders. Therefore, the present review will help in the discovery of new therapy for PD and HD patients.
- | Preclinical, Journal: Fn14 exacerbates acute lung injury by activating the NLRP3 inflammasome in mice. (Pubmed Central) - Aug 7, 2022
Our study first reports that the activation of Fn14 aggravates ALI by amplifying the activation of NLRP3 inflammasome. Therefore, blocking Fn14 may be a potential way to treat ALI.
- | Journal: Heme-stress activated NRF2 skews fate trajectories of bone marrow cells from dendritic cells towards red pulp-like macrophages in hemolytic anemia. (Pubmed Central) - Aug 6, 2022
The heme-induced phenotype of macrophage expansion with concurrent dendritic cell depletion was reproduced in hemolytic mice with sickle cell disease and spherocytosis and associated with reduced dendritic cell functions in the spleen. Our data provide a novel mechanistic underpinning of hemolytic stress as a driver of hyposplenism-related secondary immunodeficiency.