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17 Companies | 12 Products |
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36 Diseases | |
50 Trials |  |
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- | Journal: Accelerated Bone Regeneration by an Astaxanthin-Modified Antioxidant Aerogel through Relieving Oxidative Stress via the NRF2 Signaling Pathway. (Pubmed Central) - Oct 12, 2022
Taken together, ATX-Col aerogels can accelerate bone regeneration by relieving oxidative stress via the NRF2 signaling pathway and act as a potential bone graft for CSBD. This study provides a simple method of developing antioxidant aerogels for bone regeneration.
- | Journal: Plants powering muscle: The effects of phytochemical PB125 on mitochondrial function and skeletal muscle health. (Pubmed Central) - Oct 12, 2022
This study provides a simple method of developing antioxidant aerogels for bone regeneration. No abstract available
- | Preclinical, Journal: Agmatine-mediated inhibition of NMDA receptor expression and amelioration of dyskinesia via activation of Nrf2 and suppression of HMGB1/RAGE/TLR4/MYD88/NF-κB signaling cascade in rotenone lesioned rats. (Pubmed Central) - Oct 11, 2022
No abstract available The current investigated data signifies the novel role of agmatine in ameliorating both PD and dyskinesia through mediating NMDA receptors, Nrf2, and HMGB1/RAGE/TLR4/NF-κB signaling pathways.
- | palmatine / LKT Labs
Preclinical, Journal: Tianhuang formula reduces the oxidative stress response of NAFLD by regulating the gut microbiome in mice. (Pubmed Central) - Oct 11, 2022
Tianhuang formula (TH) has been proved to have a lipid-lowering effect in which constituents of ginsenoside Rb1, ginsenoside Rg1, ginsenoside Rb, ginsenoside Re, and ginsenoside R1 from Panax notoginseng and berberine, palmatine, and coptisine from Coptis chinensis have low drug permeability, which results in poor intestinal absorption into the human body, and are thus able to come into contact with the gut microflora for a longer time...The traditional Chinese medicine TH improved NAFLD by regulating the gut microbiome, and its mechanism was related to the "Lactobacillus-5-MIAA-Nrf2" pathway. It provided a promising way for the intervention of NAFLD.
- | Preclinical, Journal: Antioxidant activity and protective effect of wheat germ peptides in an in vitro celiac disease model via Keap1/Nrf2 signaling pathway. (Pubmed Central) - Oct 11, 2022
By studying the key protein expression levels of the Kelch-like ECH-associated protein 1 (Keap1)/NF-E2-related factor 2 (Nrf2) pathway, the results show that WGPs could activate Nrf2 and glutamate-cysteine ligase catalytic subunit (GCLC) up-regulation. For glutamate-cysteine ligase modifier (GCLM), WGP2 and WGP7 lead to its down-regulation, while WGP11 leads to its significant up-regulation.The present study found that peptides from wheat germ can effectively mitigate the cellular damage induced by the ɑ-gliadin peptide, which provides a new perspective for the prevention and treatment of CD.
- | Journal: miR-602 Activates NRF2 Antioxidant Pathways to Protect HBMECs from OGD/R-Induced Oxidative Stress via Targeting KEAP1 and HRD1. (Pubmed Central) - Oct 11, 2022
Besides, it was found that KEAP1 and HRD1 were downstream factors of miR-602, and the increase of both KEAP1 and HRD1 could reverse the effects of miR-602 on the OGD/R-induced HMBECs. Therefore, miR-602 may be a potential target for research and treatment of the oxidative stress injury induced by apoptosis in HMBECs.
- | acetylcysteine solution / Generic mfg.
Preclinical, Journal: N-Acetylserotonin is an oxidation-responsive activator of Nrf2 ameliorating colitis in rats. (Pubmed Central) - Oct 11, 2022
Chromatographic and mass analyses demonstrated that Oxi-NAS was the iminoquinone form of NAS and could react with N-acetylcysteine possessing a nucleophilic thiol to form a covalent adduct...Rectal NAS mitigated colonic damage and inflammation. The anti-colitic effects were significantly compromised by the co-administration of an HO-1 inhibitor.
- Activation of Nrf2-mediated protective pathways by nature-inspired hybrids improves proteostasis in retinal pigment epithelial cells () - Oct 10, 2022 - Abstract #EVER2022EVER_611;
- Activation of Nrf2-mediated protective pathways by nature-inspired hybrids improves proteostasis in retinal pigment epithelial cells (Gaudi 1) - Oct 10, 2022 - Abstract #EVER2022EVER_454;
- Vumerity (diroximel fumarate) / Biogen
Diroximel fumarate protects against opioid-induced hyperalgesia and tolerance in mice (SDCC Halls B-H) - Oct 10, 2022 - Abstract #Neuroscience2022NEUROSCIENCE_12597;
Therefore, our study shows that DRF has the potential to partially prevent the development of OIH and tolerance, thereby suggesting that DRF has opioid-sparing properties. Future studies will investigate the effects of DRF on other adverse effects of opioids.
- Inflammasome activation after peripheral nerve injury and its prevention by nuclear factor erythroid 2-related factor 2 (NRF2) (SDCC Halls B-H) - Oct 10, 2022 - Abstract #Neuroscience2022NEUROSCIENCE_8317;
Different inflammasomes may be responsible for IL-1β processing and release in males and females. Although inflammasome components are upregulated in DRG, there is little pore formation, suggesting additional regulation of IL-1β release at this site.
- Bdnf can cross the cell membrane to control the keap1-nrf2 cytoprotective system (SDCC Halls B-H) - Oct 10, 2022 - Abstract #Neuroscience2022NEUROSCIENCE_8312;
This study challenges dogma and establishes a new concept in which a protein known to exert its effects by activating its receptors, can also cross the cell membrane to induce a direct cytosolic action. This novel form of communication, whereby a receptor ligand-protein exerts a biological activity by crossing the cell membrane, opens new avenues for cell signaling.
- Ssh1-mediated suppression of the nrf2 antioxidant pathway in cellular and in vivo models of tauopathy (SDCC Halls B-H) - Oct 10, 2022 - Abstract #Neuroscience2022NEUROSCIENCE_8264;
In the PS19 mouse model of tauopathy, loss of SSH1 significantly mitigates markers of oxidative stress, increases Nrf2 nuclear to cytosol ratio, mitigates tauopathy, and rescues long-term synaptic plasticity deficits. These results elucidate a new function of SSH1 that plays a significant negative regulatory role in the Nrf2 antioxidant pathway relevant for AD and other tauopathies.
- Non-electrophilic Bach1 inhibitor attenuates progression of Alzheimer's Disease-like pathology in the APP/PS1 mouse model. (SDCC Halls B-H) - Oct 10, 2022 - Abstract #Neuroscience2022NEUROSCIENCE_8158;
Functional genomics analysis demonstrated that the neuroprotective effects of Bach1 inhibition was due to upregulation of Bach1-targeted pathways that are associated with both Nrf2-dependent antioxidants response element (ARE) and Nrf2-independent non-ARE genes. Our findings suggest that HPPE treatment after the onset of AD pathology can reverse/slow further progression of AD-like pathology and that Bach1 inhibition is a promising therapeutic approach.
- Gulf War toxicant exposure dysregulates Arc and dendritic arborization in the mouse hippocampus (SDCC Halls B-H) - Oct 10, 2022 - Abstract #Neuroscience2022NEUROSCIENCE_5439;
GWI mice also presented chronic dendritic arbor reduction loss of spines in granule cells at 14 weeks post-exposure which was reversed by the neuroprotective treatment. Our results suggest that IEGs may only be dysregulated immediately following exposure but could contribute to long-term detrimental effects on hippocampal neuroplasticity, which may be improved with induction of neuroprotective factors.
- 4-octyl itaconate attenuates toxins-induced neuronal cell death via activation of the glial nrf2 pathway in the cellular model of parkinson's disease (SDCC Halls B-H) - Oct 10, 2022 - Abstract #Neuroscience2022NEUROSCIENCE_2687;
Our present study provides compelling evidence that OI exerts a dramatic anti-inflammatory effect on microglia, resulting in neuron survival against toxin-induced cell death in vitro. Our results of OI’s ability to curb neuronal degeneration via microglia cells call for future research to pursue itaconate and its derivatives as a therapeutic strategy against PD.
- Curcumin activates p62-mediated autophagy via regulating Nrf2-Keap1 pathway in rotenone-induced parkinsonian mouse model (SDCC Halls B-H) - Oct 10, 2022 - Abstract #Neuroscience2022NEUROSCIENCE_1478;
Whereas, curcumin treatment showed significant decrease in expression of autophagy substrate p62 along with down-regulation of α-syn expression and increased level of LC3-II. Consequently, the findings reveal the neuroprotective role of curcumin in rotenone-intoxicated mice by activating p62-dependent Keap1-Nrf2 autophagy pathway.Keywords: Parkinson’s disease; Autophagy; Nrf2-Keap1 Pathway; Oxidative stress; Protein aggregation
- | Journal: Curcumin: A potential exogenous additive for the prevention of LPS-induced duck ileitis by the alleviation of inflammation and oxidative stress. (Pubmed Central) - Oct 9, 2022
In conclusion, dietary CUR has beneficial effects on LPS-induced ileal damage, oxidative damage, and inflammatory response by inhibiting the TLR/NF-κB and activating the Nrf2 signaling pathways in ducks. This study provides valuable information regarding the therapeutic uses of CUR in duck ileitis.
- Genomic and Epigenomic Profiling for Target Discovery in Translocation Renal Cell Carcinoma () - Oct 8, 2022 - Abstract #KCRS2022KCRS_3;
Modulation of this pathway may a potential strategy for overcoming drug resistance in tRCC. Keywords Translocation renal cell carcinoma; genomics; TFE3; TFEB; MITF; NRF2; VEGFR; immune checkpoint inhibition; immunotherapy; oxidative stress
- | Preclinical, Journal: Gingerenone A Alleviates Ferroptosis in Secondary Liver Injury in Colitis Mice via Activating Nrf2-Gpx4 Signaling Pathway. (Pubmed Central) - Oct 7, 2022
Mechanistic experiments revealed that GA activated Nrf2 in mice. Taken together, this study demonstrates that GA can alleviate ferroptosis in SLI in DSS-induced colitis mice, and its protective effects are associated with activating the Nrf2-Gpx4 signaling pathway.
- | mitomycin / Generic mfg.
Journal, IO biomarker, Synthetic lethality: Novel NRF2-activated cancer treatments utilizing synthetic lethality. (Pubmed Central) - Oct 7, 2022
An important clinical feature of these tumours is their defiance to all current anti-cancer treatment regimens, highlighting the need for the development of new therapeutic strategies to target NRF2-activated cancers. In this review, we discuss the mechanisms through which acquired NRF2 hyperactivation can result in resistance of tumours to immune checkpoint inhibitor therapies in addition to classical chemotherapeutics, and propose with examples that using a synthetic lethal strategy mediated by NRF2-target gene-dependent bioactivation of prodrugs represents a promising strategy to specifically enhance toxicity to heretofore untreatable NRF2-hyperactivated human tumours.
- | Journal: Near-infrared Nrf2 activator IR-61 dye alleviates radiation-induced lung injury. (Pubmed Central) - Oct 7, 2022
In summary, our study suggests that IR-61 effectively mitigates RILI by activating Nrf2 signalling in irradiated lung tissues. In particular, Nrf2-mediated anti-inflammatory and antioxidant effects in irradiated lung tissue macrophages play critical roles in protecting against RILI.
- | Preclinical, Journal: Mitochondrial dysfunction and impaired growth of glioblastoma cell lines caused by antimicrobial agents inducing ferroptosis under glucose starvation. (Pubmed Central) - Oct 6, 2022
Under this condition, antimicrobial agents cause cell death via ferroptosis. The findings hold promise for the treatment of glioblastoma.
- | Journal, IO biomarker: DBDPE and ZnO NPs synergistically induce neurotoxicity of SK-N-SH cells and activate mitochondrial apoptosis signaling pathway and Nrf2-mediated antioxidant pathway. (Pubmed Central) - Oct 6, 2022
The bioinformatics analysis further indicated that co-exposure affected Nrf2 activation, apoptotic factors expression and mitochondrial fusion. The findings enrich the risk perception of neurotoxicity caused by DBDPE and ZnO NPs.
- | 5-fluorouracil / Generic mfg.
Journal: Protective effect of quercetin against 5-fluorouracil-induced cardiac impairments through activating Nrf2 and inhibiting NF-κB and caspase-3 activities. (Pubmed Central) - Oct 6, 2022
However, all these changes were significantly ameliorated in Qu pre-administered rats. Conclusively, Qu counteracted 5-FU-mediated cardiotoxicity through potent antioxidant, anti-inflammatory, and anti-apoptotic effects.
- | Journal, IO biomarker: Lycopene attenuates the inflammation and apoptosis in aristolochic acid nephropathy by targeting the Nrf2 antioxidant system. (Pubmed Central) - Oct 6, 2022
It was concluded that lycopene was able to activate the Nrf2 antioxidant signaling pathway to maintain the homeostasis of renal oxidative stress and ultimately attenuated renal inflammatory response and apoptosis. These results suggested that lycopene can be used as a drug to relieve AAN.
- Reduced Myocardial Remodeling and Oxidative Stress by Cardiac Beta3-Adrenergic Receptors Through NRF2 Activation and the Pentose Phosphate Pathway (Virtual Only) - Oct 5, 2022 - Abstract #AHA2022AHA_8015;
Mechanistically, this could result from an increase in both the transcript abundance and nuclear activity of the transcription factor NRF2 observed in B3-tg AMVM (1,47 ± 0,13 fold increase). We conclude that moderate expression of cardiac B3AR, as seen in human hearts, exerts antioxidant effects through activation of the PPP and NRF2 pathway, thereby preserving myocardial function and integrity under hemodynamic stress.
- | nitrofurantoin / Generic mfg.
Journal: Stimulation of de novo glutathione synthesis by nitrofurantoin for enhanced resilience of hepatocytes. (Pubmed Central) - Oct 5, 2022
Repurpose of the antibiotic NFT as activator of Nrf2 could thus be a promising strategy for a transient and targeted activation of the endogenous antioxidant machinery. Graphical abstract.
- | LY294002 / Eli Lilly
Preclinical, Journal: Chronic infusion of ELABELA alleviates vascular remodeling in spontaneously hypertensive rats via anti-inflammatory, anti-oxidative and anti-proliferative effects. (Pubmed Central) - Oct 5, 2022
We further revealed that exogenous ELA-21-induced inhibition of proliferation and PI3K/Akt signaling were amplified by the PI3K/Akt inhibitor LY294002, while the APJ receptor antagonist F13A abolished ELA-21-induced PI3K/Akt inhibition and Nrf2 activation in VSMCs. In conclusion, we demonstrate that ELA-21 alleviates vascular remodeling through anti-inflammatory, anti-oxidative and anti-proliferative effects in SHRs, indicating that ELA-21 may be a therapeutic agent for treating hypertension.
- | doxorubicin hydrochloride / Generic mfg.
Journal: PRMT4 promotes ferroptosis to aggravate doxorubicin-induced cardiomyopathy via inhibition of the Nrf2/GPX4 pathway. (Pubmed Central) - Oct 5, 2022
Importantly, the detrimental role of PRMT4 in DOX-induced cardiomyocyte ferroptosis was abolished by Nrf2 activation or Fer-1 administration. Collectively, our data reveal that PRMT4 inhibits Nrf2/GPX4 signaling to accelerate ferroptosis in DIC, suggesting that targeting PRMT4 may present as a potential preventive strategy against the development of DIC.
- || Review, Journal: Exploring Nrf2 as a therapeutic target in testicular dysfunction. (Pubmed Central) - Oct 5, 2022
The Nrf2 activation could serve as a promising therapeutic target for testicular dysfunction. This review explored the effect of Nrf2 on testicular function while highlighting potential activators and inhibitors of Nrf2.
- | acetylcysteine solution / Generic mfg.
Journal: Pyrogallol enhances therapeutic effect of human umbilical cord mesenchymal stem cells against LPS-mediated inflammation and lung injury via activation of Nrf2/HO-1 signaling. (Pubmed Central) - Oct 5, 2022
Moreover, the modulation of Keap1 and Nrf2 as well as HO-1 upregulation by pyrogallol was reversed by pretreatment with N-acetylcysteine (NAC) and a P38 kinase inhibitor (SB203580)...Compared to untreated hUCMSCs, Sprague-Dawley (SD) rats with pyrogallol-primed hUCMSCs transplantation showed enhanced improvements in LPS-mediated lung pathological alterations, the increased lung index (lung/body ratio), apoptosis of epithelial cells, the activation of TLR4/NF-κB signaling as well as the release of pro-inflammatory mediators. Together, these results suggested that hUCMSCs with pyrogallol pretreatment enhanced the therapeutic efficacy of hUCMSCs, which may provide a promising therapeutic strategy to maximize the therapeutic efficacy of hUCMSC-based therapy for treating LPS-associated ALI.
- | Preclinical, Journal: Conjugated linoleic acid downregulates Alzheimer's hallmarks in aluminum mouse model through an Nrf2-mediated adaptive response and increases brain glucose transporter levels. (Pubmed Central) - Oct 5, 2022
Interestingly, animal pre-treatment with an allometric CLA dose led to significant downregulation of the toxic effects elicited by L or H, likely through the activation of an adaptive response. In conclusion, CLA ability to increase the level of glucose transporters - along with its antioxidant and anti-inflammatory effect - expands the therapeutic targets of these molecules and comes out as an intriguing suitable candidate for the treatment of multifactorial disease.
- | Journal: Mechanisms underlying Nrf2 nuclear translocation by non-lethal levels of hydrogen peroxide: p38 MAPK-dependent neutral sphingomyelinase2 membrane trafficking and ceramide/PKCζ/CK2 signaling. (Pubmed Central) - Oct 5, 2022
We propose that Cav1serves as a signaling hub for the control of HO-mediated phosphorylation of Nrf2 by kinases, which results in release of Nrf2 from Cav1 to facilitate nuclear translocation. In summary, HO induces GSH depletion which is recovered by Nrf2 activation dependent on p38/nSMase2/ceramide signaling.
- | Journal: Biotinylation of an acetylenic tricyclic bis(cyanoenone) lowers its potency as an NRF2 activator while creating a novel activity against BACH1. (Pubmed Central) - Oct 5, 2022
TBE56 degrades BACH1 in lung and breast cancer cells, impairing breast cancer cell migration and invasion in a BACH1-dependent manner, while TBE31 has no significant effect. Altogether, our study identifies that the biotinylation of TBE31 provides novel activities with potential therapeutic value, providing a rationale for further characterisation of this and related compounds.
- | Journal: Sinomenine pretreatment alleviates hepatic ischemia/reperfusion injury through activating Nrf-2/HO-1 pathway. (Pubmed Central) - Oct 5, 2022
Altogether, our study identifies that the biotinylation of TBE31 provides novel activities with potential therapeutic value, providing a rationale for further characterisation of this and related compounds. Altogether, our results demonstrate that SIN might be a useful therapeutic drug for preventing hepatic IR-induced injury during clinical liver transplantation.
- | Journal: Melatonin alleviates arginine vasopressin-induced cardiomyocyte apoptosis via increasing Mst1-Nrf2 pathway activity to reduce oxidative stress. (Pubmed Central) - Oct 4, 2022
These findings were supported by siRNA gene suppression, where knocking down either Nrf2 or Mst1 abrogated the anti-apoptotic effects of Mel in cardiomyoblasts. Therefore, Mel could reduce cardiomyoblast apoptosis under high AVP levels, via Mst1-Nrf2 pathway re-activation, to enhance anti-oxidative responses.
- | Kinedak (epalrestat) / Ono Pharma
Journal: Elucidation and Application of Novel Action of Therapeutic Agents for Diabetic Neuropathy (Pubmed Central) - Oct 4, 2022
The results can be applied to the development of existing drugs for use as medicines for the treatment of other diseases. This review provides useful findings for future expansion of indications as research leading to drug repurposing of epalrestat.
- | Journal, IO biomarker: Forsythiaside Protected H9c2 Cardiomyocytes from HO-Induced Oxidative Stress and Apoptosis via Activating Nrf2/HO-1 Signaling Pathway. (Pubmed Central) - Oct 4, 2022
SiNrf2 reversed the functions of HO or Forsythiaside in cell viability, MDA, SOD, GSH-Px, CAT, Nrf2, and HO-1 in H9c2 cells, whereas Forsythiaside reversed the aforementioned effects of siNrf2. In sum, Forsythiaside protected H9c2 cells from oxidative stress and apoptosis induced by HO by activating the Nrf2/HO-1 pathway.
- | Journal: Traditional Chinese medicine prescriptions (XJZ, JSS) ameliorate spleen inflammatory response and antioxidant capacity by synergistically regulating NF-κB and Nrf2 signaling pathways in piglets. (Pubmed Central) - Oct 4, 2022
Notably, the results of PCA and network correlation analysis indicated that XJZ and JSS treatment altered the expression profiles of inflammatory and antioxidant-related factors in the spleen of weaned-piglets, which may involve the synergy of NF-κB and Nrf2 signaling pathways. In summary, our study showed that TCM prescriptions, XJZ and JSS could ameliorate inflammatory response and antioxidant capacity in the spleen by synergistically regulating NF-κB and Nrf2 signaling pathways in piglets.
- | Journal: Ginkgo biloba extracts (GBE) protect human RPE cells from t-BHP-induced oxidative stress and necrosis by activating the Nrf2-mediated antioxidant defence. (Pubmed Central) - Oct 4, 2022
This study revealed that GBE pre-treatment attenuates pro-oxidant stress and protects human RPE cells from oxidative injury by modulating ERK1/2-Nrf2 axis. These findings suggest that GBE has the potential to be developed as a agent that may be valuable in decreasing AMD progression.
- | cisplatin / Generic mfg.
Journal: Knockout of NRF2 triggers prostate cancer cells death through ROS modulation and sensitizes to cisplatin. (Pubmed Central) - Oct 4, 2022
Reduced levels of KU70 and phospho-CHK2 (p < 0.05) were also detected. The data presented here support that NRF2 is a mediator of oncogenesis and could be a potential target to sensitize PCa cells to chemotherapy, reinforcing the importance of knowing the specific genetic and biochemical characteristics of the cancer cells for a more effective approach against cancer.
- | Journal: ACE2 deficiency exacerbates obesity-related glomerulopathy through its role in regulating lipid metabolism. (Pubmed Central) - Oct 2, 2022
By contrast, ACE2 overexpression reactivated Nrf2 pathway and ameliorated ORG symptoms by decreasing fat deposition and reducing inflammatory responses. Our data demonstrated that ACE2 exerted the beneficial effects by acting through Nrf2 signaling pathway, suggesting the protective role of ACE2 against lipid accumulation and inflammatory responses in ORG pathogenesis.
- | Journal: Icariin protects vertebral endplate chondrocytes against apoptosis and degeneration via activating Nrf-2/HO-1 pathway. (Pubmed Central) - Oct 1, 2022
In conclusion, our study demonstrated that ICA could protect against CEP degeneration and calcification under IVDD pathological conditions, the associated mechanism may be related to Nrf-2/HO-1-mediated mitophagy activation and ferroptosis inhibition. Our results suggest that ICA may be a potential effective medicine for IVDD prevention and treatment.
- | sirolimus / Generic mfg., captopril / Generic mfg., acarbose / Generic mfg.
Preclinical, Journal, Heterogeneity: Lifespan benefits for the combination of rapamycin plus acarbose and for captopril in genetically heterogeneous mice. (Pubmed Central) - Oct 1, 2022
None of the other 4 tested agents led to any lifespan benefit. The C2017 ITP dataset shows that combinations of anti-aging drugs may have effects that surpass the benefits produced by either drug used alone, and that additional studies of captopril, over a wider range of doses, are likely to be rewarding.
- | paracetamol / Generic mfg.
Journal: Astaxanthin Activated the Nrf2/HO-1 Pathway to Enhance Autophagy and Inhibit Ferroptosis, Ameliorating Acetaminophen-Induced Liver Injury. (Pubmed Central) - Oct 1, 2022
Furthermore, we developed ASX-loaded hollow mesoporous silica nanoparticles (HMSN@ASX) to improve the aqueous solubility of ASX and targeted delivery of ASX to the liver and then significantly improve the therapeutic effects. Taken together, we found that ASX can protect against AILI by activating the Nrf2/HO-1 pathway, which mainly affects oxidative stress, autophagy, and ferroptosis processes, and the HMSN@ASX nanosystem can target the liver to enhance the treatment efficiency of AILI.
- | Journal: Phenolic Metabolites from a Deep-Sea-Derived Fungus Aspergillus puniceus A2 and Their Nrf2-Dependent Anti-Inflammatory Effects. (Pubmed Central) - Oct 1, 2022
We further found that pharmacological inhibition of Nrf2 by ML385 largely abrogated the effects of 1-6 on RAW264.7 cells. Therefore, 1-6 may share a common anti-inflammatory mechanism via Nrf2 upregulation and activation.
- | selenomethionine (SLM) / University of Iowa, Holden Comprehensive Cancer Center
Preclinical, Journal: Protective Effect of SeMet on Liver Injury Induced by Ochratoxin A in Rabbits. (Pubmed Central) - Oct 1, 2022
Recent studies have shown that selenomethionine (SeMet) has a protective effect on mycotoxin-induced toxicity...In addition, OTA poisoning inhibits Nrf2 and HO-1 levels, ultimately leading to peroxide reaction, while SeMet activates the Nrf2 signaling pathway and enhances the expression of the HO-1 downstream Nrf2 gene. These results suggest that Se protects the liver from OTA-induced hepatotoxicity by regulating Nrf2/HO-1 expression.
- || bardoxolone methyl (RTA 402) / Kyowa Kirin, Reata
Review, Journal: Oxidative Stress and NRF2/KEAP1/ARE Pathway in Diabetic Kidney Disease (DKD): New Perspectives. (Pubmed Central) - Oct 1, 2022
However, limitations regarding the lack of larger clinical trials, solubility or delivery hamper their implementation for clinical use. Therefore, in this review, we will discuss DKD mechanisms, especially oxidative stress (OS) and NRF2/KEAP1/ARE involvement, while highlighting the potential of therapeutic approaches that target DKD via OS.
- | Preclinical, Journal: Melatonin Attenuates Spinal Cord Injury in Mice by Activating the Nrf2/ARE Signaling Pathway to Inhibit the NLRP3 Inflammasome. (Pubmed Central) - Oct 1, 2022
Therefore, in this review, we will discuss DKD mechanisms, especially oxidative stress (OS) and NRF2/KEAP1/ARE involvement, while highlighting the potential of therapeutic approaches that target DKD via OS. In conclusion, melatonin inhibits the NLRP3 inflammasome through stimulation of the Nrf2/ARE pathway, thereby suppressing neuroinflammation, reducing mitochondrial dysfunction, and improving the recovery of nerve function after SCI.