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17 Companies | 12 Products |
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36 Diseases | |
50 Trials |  |
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- | Journal: Banana peel ameliorated hepato-renal damage and exerted anti-inflammatory and anti-apoptotic effects in metal mixture mediated hepatic nephropathy by activation of Nrf2/ Hmox-1 and inhibition of Nfkb pathway. (Pubmed Central) - Oct 22, 2022
BP was protective against metal mixture induced histopathological distortions. HMM exposure significantly distorted hepatorenal functions and BP treatment reduced metal bioavailability and abrogated most of these alterations.
- | Journal: Activation of Nrf2 signaling by 4-octyl itaconate attenuates the cartilaginous endplate degeneration by inhibiting E3 ubiquitin ligase ZNF598. (Pubmed Central) - Oct 22, 2022
4OI may alleviate IVDD by suppressing CEP degeneration and macrophage-associated inflammation. 4OI may be an alternative therapy for degenerative CEPs/IVDs.
- | Journal: Trehalose prevents glyphosate-induced hepatic steatosis in roosters by activating the Nrf2 pathway and inhibiting NLRP3 inflammasome activation. (Pubmed Central) - Oct 21, 2022
Additionally, Tre treatment evidently mitigated Gly-induced inflammasome response via inhibiting NLRP3 inflammasome activation. Overall, these observations provide novel insights that the protective action of Tre against Gly-induced hepatic steatosis is attributed to activation of Nrf2 pathway and inhibition of NLRP3 inflammasome activation.
- | Journal: Naringenin Alleviates Renal Ischemia Reperfusion Injury by Suppressing ER Stress-Induced Pyroptosis and Apoptosis through Activating Nrf2/HO-1 Signaling Pathway. (Pubmed Central) - Oct 21, 2022
Importantly, the application of 4-PBA showed that renal I/R-generated pyroptosis and apoptosis were able to be regulated by ER stress in vivo and in vitro. In conclusion, naringenin suppressed ER stress by activating Nrf2/HO-1 signaling pathway and further alleviated pyroptosis and apoptosis to protect renal against I/R injury.
- | deferoxamine / Generic mfg.
Preclinical, Journal: Protective effects of Salvianolic acid B on rat ferroptosis in myocardial infarction through upregulating the Nrf2 signaling pathway. (Pubmed Central) - Oct 21, 2022
Importantly, treatment of ferroptosis inhibitors ferrostatin-1 (Fer-1) or deferoxamine (DFO) reversed typical changes of ferroptosis, including iron overload, lipid peroxide accumulation, mitochondrial damage, and specific expression levels of ferroptosis-related proteins, thereby alleviating myocardial injury in rats...Furthermore, Sal B administration was unable to significantly reverse expression levels of target genes of Nrf2 that were associated with iron homeostasis and oxidative stress (e.g., HO-1, xCT, Gpx4, Fth1, and Fpn1) in MI rats after knockdown of Nrf2. Taken together, Sal B contributed to protecting MI by inhibiting ferroptosis via activating the Nrf2 signaling pathway.
- | Journal: Free and Bound Phenolics of Laird Lentil (Lens culinaris) Hulls and the Anti-inflammatory Activity of their Digestive Products via Crosstalk between NF-κB and Keap1-Nrf2 Signaling Pathways in HT-29 Cells. (Pubmed Central) - Oct 21, 2022
These digestive products could reduce inflammatory mediators and exert anti-inflammatory activity by inhibiting NF-κB and activating Keap1-Nrf2 signaling pathways, and there was crosstalk between them, which was a mutual inhibition effect. The results show that polyphenols in lentil hulls are a good source of anti-inflammatory ingredients and have a promising development potential.
- | Journal: Akebia Saponin D Inhibits the Inflammatory Reaction by Inhibiting the IL-6-STAT3-DNMT3b Axis and Activating the Nrf2 Pathway. (Pubmed Central) - Oct 21, 2022
Furthermore, DNMT3b siRNA and Nrf2 siRNA significantly promoted the anti-inflammatory effect of ASD. Our study demonstrates for the first time that ASD inhibits the IL-6-STAT3-DNMT3b axis and activates the nuclear factor-E2-related factor 2 (Nrf2) signaling pathway to achieve its inhibitory effect on inflammatory reactions.
- | bardoxolone methyl (RTA 402) / Kyowa Kirin, Reata
Preclinical, Journal: Gastrodin Ameliorates Cognitive Dysfunction in Vascular Dementia Rats by Suppressing Ferroptosis via the Regulation of the Nrf2/Keap1-GPx4 Signaling Pathway. (Pubmed Central) - Oct 21, 2022
Furthermore, compared with GAS alone, GAS combined with Bardoxolone (an agonist of Nrf2) did not further affect the increase in GPx4 levels and decrease in COX2 levels, nor did it further affect the regulation of GAS on the biochemical parameters of ferroptosis in HT22 hypoxia injury. These findings revealed that GAS inhibited ferroptosis in hippocampal neurons by activating the Nrf2/Keap1-GPx4 signaling pathway, suggesting its possible application as a functional food for improving vascular dementia by inhibiting ferroptosis.
- | selisistat (SEN-196) / AOP Orphan Pharma
Preclinical, Journal: Mesenchymal Stem Cell-Derived Exosomes Ameliorate Delayed Neurocognitive Recovery in Aged Mice by Inhibiting Hippocampus Ferroptosis via Activating SIRT1/Nrf2/HO-1 Signaling Pathway. (Pubmed Central) - Oct 21, 2022
Interestingly, the above effects of MSCs-Exo on dNCR aged mice were abolished by SIRT1 selective inhibitor EX-527. In conclusion, these findings indicated that MSCs-Exo can ameliorate cognitive impairment by inhibiting hippocampus ferroptosis in dNCR aged mice via activating SIRT1/Nrf2/HO-1 signaling pathway, providing a potential avenue for the treatment of dNCR.
- | Journal: Protective Role of Corticosterone against Hydrogen Peroxide-Induced Neuronal Cell Death in SH-SY5Y Cells. (Pubmed Central) - Oct 20, 2022
Furthermore, pretreatment of CORT attenuated HO-mediated oxidative damages by upregulation of antioxidant enzymes via activation of nuclear factor erythroid 2-related factor 2 (Nrf2). These findings suggest that low concentration of CORT with eustressed condition enhances intracellular self-defense against HO-mediated oxidative cell death, suggesting a role of low concentration of CORT as one of key molecules for resilience and neuronal cell survival.
- | Preclinical, Journal: Melatonin protects porcine oocyte from copper exposure potentially by reducing oxidative stress potentially through the Nrf2 pathway. (Pubmed Central) - Oct 19, 2022
Notably, Nrf2 protein expression was significantly increased by copper exposure, meanwhile, Nrf2 signaling pathway inhibitor ML385 significantly attenuated the protective role of melatonin on oxidative stress induced by copper exposure. In summary, our study demonstrates that copper activates the Nrf2 pathway and impairs oocyte maturation by inducing oxidative stress, leading to poor quality of porcine oocytes, and the changes can be reversed by melatonin.
- | Journal, IO biomarker: Total terpenoids of Inula japonica activated the Nrf2 receptor to alleviate the inflammation and oxidative stress in LPS-induced acute lung injury. (Pubmed Central) - Oct 19, 2022
In summary, our study demonstrates that copper activates the Nrf2 pathway and impairs oocyte maturation by inducing oxidative stress, leading to poor quality of porcine oocytes, and the changes can be reversed by melatonin. TTIJ could activate the Nrf2 receptor to alleviate the inflammatory response and oxidative stress in LPS-induced ALI mice, which suggested that TTIJ could serve as the potential agent in the treatment of ALI.
- | Journal: Caspase-8 mutants activate Nrf2 via phosphorylating SQSTM1 to protect against oxidative stress in esophageal squamous cell carcinoma. (Pubmed Central) - Oct 19, 2022
Therefore, our study demonstrated that caspase-8 mutants gain a new function of protecting against oxidative stress via the mTOR/SQSTM1/Keap1/Nrf2 axis in ESCC. Caspase-8 status may be a new prognostic factor for survival in ESCC patients.
- | Preclinical, Journal: Knockdown of CBX7 inhibits ferroptosis in rats with cerebral ischemia and improves cognitive dysfunction by activating the Nrf2/HO-1 pathway. (Pubmed Central) - Oct 19, 2022
Lastly, expressions of Nrf2, HO-1 and NAD(P)H:quinone oxidoreductase 1 (NQO1) were up-regulated in ischemic rats post sh-CBX7 injection. In conclusion, suppression of CBX7 attenuated I/R injury, improved cognitive dysfunction and inhibited ferroptosis through the activation of the Nrf2/HO-1 signaling pathway.
- | Journal: Zhen Wu decoction represses renal fibrosis by invigorating tubular NRF2 and TFAM to fuel mitochondrial bioenergetics. (Pubmed Central) - Oct 19, 2022
ZWD maintains mitochondrial integrity and improves OXPHOS which represents an innovative insight into "strengthening Yang-Qi" theory. ZWD limits tubular fibrogenesis by reinvigorating tubular bioenergetic capacity.
- | Journal: Activation of Nrf2 modulates protective immunity against Mycobacterium tuberculosis infection in THP1-derived macrophages. (Pubmed Central) - Oct 18, 2022
Combined, our results extend the understanding of the complex innate immunity regulation by Nrf2 against mycobacterial infection. Also, these findings suggested that the regulation of Nrf2 signaling cascade could be used as a therapeutic target for the treatment of TB patients and the development of better anti-TB vaccines.
- | Journal: Sulforaphane promotes white matter plasticity and improves long-term neurological outcomes after ischemic stroke via the Nrf2 pathway. (Pubmed Central) - Oct 18, 2022
Our results support that Nrf2 is critical for Sfn-afforded neuroprotection after ischemic stroke. Thus, targeting Nrf2 may be a promising strategy for the treatment of PSCI.
- || Review, Journal: Regulation of nuclear factor erythroid-2-related factor 2 as a potential therapeutic target in intracerebral hemorrhage. (Pubmed Central) - Oct 18, 2022
We further reviewing the efficacy of several Nrf2 activators in the treatment of ICH in experimental ICH models. Activation of Nrf2 might produce antioxidant, anti-inflammatory, and neuron-protection effects, which could potentially be a focus for developing future treatments and prevention of ICH.
- | Journal: BRD4 Silencing Protects Angiotensin II-Induced Cardiac Hypertrophy by Inhibiting TLR4/NF-κB and Activating Nrf2-HO-1 Pathways. (Pubmed Central) - Oct 18, 2022
Additionally, TLR4 overexpression attenuated an increase in Nrf2 and HO-1 proteins and decreased phosphorylated NF-kappa B in H9c2 cells. Our results speculate that the BRD4/TLR4 axis might be a promising strategy for treating cardiovascular diseases with cardiac hypertrophy, including HF.
- | Preclinical, Journal: Analysis of the Renal Protection and Antioxidative Stress Effects of Panax notoginseng Saponins in Diabetic Nephropathy Mice. (Pubmed Central) - Oct 18, 2022
Compared with the model group, PNS dose-dependently increased Nrf2 and HO-1 levels in DN mice. PNS is protective of HFF + STZ-induced DN mice against kidney tissue damage and can reduce the excretion of UPro and relieve the OS state of mice, possibly by activating Nrf2/HO-1 axis to play an antioxidant and anti-inflammatory role.
- | Journal: Apomorphine Reduces A53T α-Synuclein-Induced Microglial Reactivity Through Activation of NRF2 Signalling Pathway. (Pubmed Central) - Oct 18, 2022
Suppressing NRF2 recruitment (trigonelline exposure) or silencing specifically Nfe2l2 gene (siRNA treatment) abolished or strongly decreased the anti-inflammatory activity of apomorphine. In conclusion, apomorphine, which is already used in PD patients to mimic dopamine activity, may also be suitable to decrease α-synuclein-induced microglial reactivity.
- | Journal: Hace1 overexpression mitigates myocardial hypoxia/reoxygenation injury via the effects on Keap1/Nrf2 pathway. (Pubmed Central) - Oct 18, 2022
In short, these data demonstrated that Hace1 overexpression mitigated myocardial H/R injury by enhancing the Nrf2 pathway via Keap1. This work underlines a possible role of Hace1 in myocardial ischemia/reperfusion injury and suggests Hace1 as a candidate target for exploiting cardioprotective therapy.
- | Preclinical, Journal: Cycloastragenol suppresses M1 and promotes M2 polarization in LPS-stimulated BV-2 cells and ischemic stroke mice. (Pubmed Central) - Oct 18, 2022
Together, our results suggested that CAG promoted microglial M2 and suppressed M1 polarization through activating Nrf2 and inhibiting NF-κB, respectively, in LPS-stimulated BV-2 cells and ischemic mouse brain. CAG is a promising candidate for the treatment of neuroinflammation-related diseases, including ischemic stroke.
- | Preclinical, Journal: Investigation of the toxicity of a glyphosate-based herbicide in a human liver cell line: Assessing the involvement of Nrf2 pathway and protective effects of vitamin E and α-lipoic acid. (Pubmed Central) - Oct 18, 2022
Investigation of the protective effects of antioxidants vitamin E (Vit E) and α-lipoic acid (LA) against Roundup toxicity showed that both antioxidants significantly reduced the cytotoxicity, ROS formation, HO-1 downregulation, and apoptosis and that Vit E did so more efficiently than LA. In conclusion, our findings highlight the ROS producing and apoptosis inducing effects associated with GBHs, the activation of Nrf2 pathway as a defense mechanism and the protective effects of Vit E and LA against GBH toxicity.
- | Journal: Dual Antioxidant DH-217 Mitigated Cerebral Ischemia-Reperfusion Injury by Targeting IKKβ/Nrf2/HO-1 Signal Axis. (Pubmed Central) - Oct 17, 2022
Dual antioxidant DH-217 not only has the ability of directly scavenging ROS, but also can clear it by targeting IKKβ/Nrf2/HO-1 signal axis. Inhibition of IKKβ phosphorylation and activation of Nrf2/HO-1 may be a promising antioxidant pathway for CIRI.
- || Review, Journal: The KEAP1-NRF2 System and Esophageal Cancer. (Pubmed Central) - Oct 15, 2022
In this review, we will summarize the current knowledge of the KEAP1-NRF2 system and the treatment of ESCC. We propose three main strategies for the treatment of NRF2-addicted cancer: (1) NRF2 inhibitors, (2) synthetic lethal drugs for NRF2-addicted cancers, and (3) NRF2 inducers of the host defense system.
- | Preclinical, Journal: Trypsin inhibitor LH011 inhibited DSS-induced mice colitis via alleviating inflammation and oxidative stress. (Pubmed Central) - Oct 15, 2022
Mechanically, LH011 downregulated the nuclear localization of NF-κB p65 and upregulated the protein expression of Nrf2. These results demonstrated that LH011 alleviated inflammation and oxidative stress during UC by inhibiting TLR4/NF-κB and activating Nrf2/Keap1/HO-1 signaling pathways.
- | dimethyl fumarate / Generic mfg., paclitaxel / Generic mfg.
Preclinical, Journal: Dimethyl Fumarate Ameliorates Paclitaxel-Induced Neuropathic Pain in Rats. (Pubmed Central) - Oct 14, 2022
DMF treatment significantly upregulated the gene expression of Nrf2 in the sciatic nerve. Conclusion These findings suggest that DMF prevented the development of PIPN in rats through the activation of Nrf2 and the inhibition of p38 MAPK and BDNF.
- | Journal: Jia-ga-song-tang protection against alcoholic liver and intestinal damage. (Pubmed Central) - Oct 14, 2022
repaired the intestinal barrier, and inhibited Nrf2 in IEC-6, but protect the HepG2 by activating Nrf2 to balance cellular homeostasis. Our results reinforce that JGST provides an effective protective method for alcoholic liver disease (ALD) by regulating Gut-liver axis and cellular homeostasis.
- | Preclinical, Journal: Nattokinase attenuates bisphenol A or gamma irradiation-mediated hepatic and neural toxicity by activation of Nrf2 and suppression of inflammatory mediators in rats. (Pubmed Central) - Oct 14, 2022
Furthermore, NK alleviated the neuroinflammation via modulating NF-κB/Nrf2/HO-1 pathway and glial cell activation in addition to their antiapoptotic effect. Collectively, the current results revealed the protective effect of NK against hepatic and neurotoxicity derived from BPA or IR.
- | Journal: Dendrobine protects HACAT cells from HO-induced oxidative stress and apoptosis damage via Nrf2/Keap1/ARE signaling pathway. (Pubmed Central) - Oct 14, 2022
However, this antioxidant effect of dendrobine was abolished after Nrf2 gene being silenced. The results showed that dendrobine could resist the oxidative damage of skin cells, and its antioxidant function is related to the up-regulation of antioxidant enzymes as well as activation of Nrf2/Keap1 signaling pathway.
- | Preclinical, Journal: Melatonin Prevents against Ethanol-Induced Liver Injury by Mitigating Ferroptosis via Targeting Brain and Muscle ARNT-like 1 in Mice Liver and HepG2 Cells. (Pubmed Central) - Oct 14, 2022
Altogether, this study revealed that melatonin could alleviate ethanol-induced liver injury by impeding ferroptosis via reprogramming the circadian protein BMAL1 and subsequently activating the Nrf2-ARE anti-ferroptosis pathway. The emergence of novel liver protective effects and mechanism of melatonin on ethanol-induced ferroptosis may provide a new dimension for prevention or intervention against liver injury associated with ethanol.
- | sevoflurane / Generic mfg.
Journal: Echinatin mitigates sevoflurane-induced hippocampal neurotoxicity and cognitive deficits through mitigation of iron overload and oxidative stress. (Pubmed Central) - Oct 14, 2022
Ech alleviates Sev-induced neurotoxicity and cognitive deficits by mitigation of ferroptosis and oxidative stress. Ech may be developed as a new promising therapeutic drug for treatment of cerebral nerve injury caused by surgical anaesthesia.
- | NexoBrid (bromelain) / MediWound, Kaken Pharma, Teva
Journal: Bromelain ameliorates D-galactosamine-induced acute liver injury: role of SIRT1/LKB1/AMPK, GSK3β/Nrf2 and NF-κB p65/TNF-α/caspase-8, -9 signalling pathways. (Pubmed Central) - Oct 14, 2022
Ech may be developed as a new promising therapeutic drug for treatment of cerebral nerve injury caused by surgical anaesthesia. Our results highlight the significant hepatoprotective effects of bromelain against acute liver injury through modulation of SIRT1/LKB1/AMPK, GSK3β/Nrf2 signalling in addition to NF-κB p65/TNF-α/ caspase-8 and -9 pathway.
- bardoxolone methyl (RTA 402) / Kyowa Kirin, Reata
ND-13, a DJ-1 Derived Peptide, as a Novel Pharmacological Approach to Activated Nrf2 in the Prevention of Inflammasome Activation in Diabetic Nephropathy (Exhibit Hall, Orange County Convention Center, West Building) - Oct 13, 2022 - Abstract #KIDNEYWEEK2022KIDNEY_WEEK_3644;
Methods Mouse bone marrow macrophages (BMM) were treated with Bardoxolone, an Nrf2 inducer, and ND-13...PBMCs isolated from the blood of patients were plate and stimulated with LPS/ATP, and patients with diabetic nephropathy presented a trend to increase IL-1β release compared to controls and diabetic individuals and ND-13 could have a role in the prevention of inflammasome activation. Conclusion All these data point out that DJ-1/Nrf2 pathway stimulation is a promising approach to decreasing immune cells inflammasome activation, and ND-13 could be a new approach to attenuate inflammation in renal diseases.
- bardoxolone methyl (RTA 402) / Kyowa Kirin, Reata
Results of Phase 2 MERLIN: An Evaluation of Safety, Tolerability, and Efficacy of Bardoxolone Methyl in Patients With Rapidly Progressing CKD (Exhibit Hall, Orange County Convention Center, West Building) - Oct 13, 2022 - Abstract #KIDNEYWEEK2022KIDNEY_WEEK_3316;
P2
Bard was found to be safe and well tolerated. Overall, no new safety signals emerged during the study.
- cisplatin / Generic mfg.
Keap1 Inhibition Ameliorates Cisplatin-Induced Mitochondrial Injury and Oxidative Stress in Renal Proximal Tubule Epithelial Cells Through a Glutathione-Dependent Mechanism (Exhibit Hall, Orange County Convention Center, West Building) - Oct 13, 2022 - Abstract #KIDNEYWEEK2022KIDNEY_WEEK_1954;
Notably, BSO treatment negated the protective effects of the Keap1−Nrf2 PPI inhibitor against cisplatin-induced mitochondrial depolarization and apoptosis, while not affecting its ability to induce the transcriptional activation of NRF2 target genes. Conclusion Together, our results show that inhibition of the Keap1–Nrf2 PPI activates the antioxidant machinery for ROS scavenging in RPTECs, and that increased levels of intracellular GSH plays an important protective role against cisplatin-induced mitochondrial dysfunction and cellular death.
- Arginine Metabolism Regulates the Transcription Factor Nrf2 and Prevents Renal Interstitial Fibrosis Through Tubular Spermidine Production (Exhibit Hall, Orange County Convention Center, West Building) - Oct 13, 2022 - Abstract #KIDNEYWEEK2022KIDNEY_WEEK_1822;
An activation of Nrf2 and downstream gene expression were suppressed in Arg2 knockout UUO kidneys. Conclusion Our data support that arginine metabolism is activated to produce Spd, which activates Nrf2 and autophagy, resulting in a protective effect against kidney fibrosis.
- sublingual immunotherapy / UNC School of Medicine
Oxidative Stress Is a Mediator of Slit Diaphragm Defects Initiated by Disruption of Endocytosis (Exhibit Hall, Orange County Convention Center, West Building) - Oct 13, 2022 - Abstract #KIDNEYWEEK2022KIDNEY_WEEK_1586;
Conclusion Our data indicate that disruption of endocytosis leads to increased ROS levels, which disrupt slit diaphragm integrity. Thus, in addition to its direct role in the trafficking of slit diaphragm proteins, endocytosis also affects slit diaphragm integrity by promoting redox balance.
- Single Cell Chromatin Accessibility Atlas During Murine Kidney Injury and Repair (Exhibit Hall, Orange County Convention Center, West Building) - Oct 13, 2022 - Abstract #KIDNEYWEEK2022KIDNEY_WEEK_1005;
Conclusion The first comprehensive snATAC-seq atlas of mouse IRI kidneys catalogued phase-specific and cell-specific activation of regulatory genomic regions and transcription factors that shape cell-specific responses to ischemic injury. Epigenetic mechanisms driving FR-PTC revealed in this study implicate potential novel therapeutic targets in AKI and its transition to chronic kidney disease.
- | Journal: Sulforaphane alleviated vascular remodeling in hypoxic pulmonary hypertension via inhibiting inflammation and oxidative stress. (Pubmed Central) - Oct 13, 2022
SFN also prevented the apoptosis of pulmonary microvascular ECs caused by hypoxia. Therefore, these data suggested that SFN could significantly restrain the inflammation and oxidative stress, thereby inhibiting PASMCs proliferation, promoting PASMCs apoptosis, and reversing hypoxia injury in ECs to improve pulmonary vascular remodeling.
- An efficient smart polymer encapsulated drug nanostructure attenuates neuroinflammation in Alzheimer’s disease via nrf2 signaling pathway (Corner 2 (Hall X1) [IN-PERSON]) - Oct 13, 2022 - Abstract #ECNP2022ECNP_1500;
These findings suggest the ability of EGCG nanoparticles in inhibiting microglia-mediated neuroinflammation by Nrf2 activation and upregulation of antioxidant genes in Aβ-induced neurotoxicity. Our present research data also provide a facile strategy for synthesizing polymeric nanoparticles as an innovative drug-delivery system for the brain delivery of potent drugs for AD treatment.
- An efficient smart polymer encapsulated drug nanostructure attenuates neuroinflammation in Alzheimer’s disease via nrf2 signaling pathway (Poster area [IN-PERSON]) - Oct 13, 2022 - Abstract #ECNP2022ECNP_660;
These findings suggest the ability of EGCG nanoparticles in inhibiting microglia-mediated neuroinflammation by Nrf2 activation and upregulation of antioxidant genes in Aβ-induced neurotoxicity. Our present research data also provide a facile strategy for synthesizing polymeric nanoparticles as an innovative drug-delivery system for the brain delivery of potent drugs for AD treatment.
- | Preclinical, Journal: Lycium barbarum polysaccharide promotes proliferation of human melanocytes via activating the Nrf2/p62 signaling pathway by inducing autophagy in vitro. (Pubmed Central) - Oct 13, 2022
We firstly confirmed the anti-vitiligo effects of L. barbarum polysaccharide (LBP) by inducing autophagy and promoted proliferation of human melanocytes, and LBP induced autophagy via activating the Nrf2/p62 signaling pathway in this study. These results proved that LBP can be an effective therapy for vitiligo treatment.
- | Preclinical, Journal: The effect of curcumin on NRF2/Keap1 signalling pathway in the epididymis of mouse experimental cryptorchidism. (Pubmed Central) - Oct 13, 2022
The expression of HO1, NQO1, and Nrf2 genes, which had decreased in the cryptorchidism group, showed a significant increase after administration of Cur in a dose-dependent manner. Cur, by inducing the expression of genes involved in the Nrf2/Keap1 pathway, could reduce the adverse effects of cryptorchidism and might be used as adjuvant therapy for decreasing cryptorchidism complications before surgery.
- | doxorubicin hydrochloride / Generic mfg.
Preclinical, Journal, IO biomarker: The protection afforded by Berberine against chemotherapy-mediated nephropathy in rats involves regulation of the antioxidant axis. (Pubmed Central) - Oct 13, 2022
Doxorubicin (DOX) treatment in cancer patients leads to nephrotoxicity...All these effects disappeared by brusatol. In conclusion, BBR prevents DOX-induced renal damage by activating Nrf2.
- | methamphetamine / Generic mfg.
Journal: Methamphetamine and HIV-1 Tat proteins synergistically induce microglial autophagy via activation of the Nrf2/NQO1/HO-1 signal pathway. (Pubmed Central) - Oct 13, 2022
And the Nrf2 pathway plays a vital role in regulating the synergistic induction of microglial autophagy by METH and HIV-1Tat protein. This study may provide a theoretical basis and new ideas for effective targets for pharmacological intervention in HIV-infected patients with drug abuse.
- | Preclinical, Journal: Avenanthramide-C Activates Nrf2/ARE Pathway and Inhibiting Ferroptosis Pathway to Improve Cognitive Dysfunction in Aging Rats. (Pubmed Central) - Oct 13, 2022
AVC pretreatment has a preventive effect on cognitive dysfunction induced by repeated propofol anesthesia in aging rats, and the preventive effect of AVC may be realized by activating the Nrf2/ARE signaling pathway activity. Our results demonstrate that AVC preconditioning reduces postoperative neuronal loss and neuroinflammation, activates the Nrf2/ARE pathway, reduces oxidative stress injury, and improves POCD in aged rats.
- |||| sapanisertib (CB-228) / Calithera
New potential targeted therapy for squamous NSCLC? TAK-228 (TORC1/2 inhibitor) in NRF2 activated NSCLC @JTOonline. In NFE2L2 mutant squamous NSCLC, RR 25% (3 out of 12) with impressive mPFS of 8.9m. Looking forward to larger studies. #LCSM https://t.co/wSSXfgCL8V (Twitter) - Oct 12, 2022
- | Journal: Pharmacological characterization of a novel peptide inhibitor of the Keap1-Nrf2 protein-protein interaction. (Pubmed Central) - Oct 12, 2022
Moreover, in cells exposed to cigarette smoke, LAS200813 shows an antioxidant effect by increasing the production of glutathione and prevents cellular apoptosis. In conclusion, the results described herein demonstrate that LAS200813 is a potent non-electrophilic Nrf2-activating peptide designed to be administered by inhaled route which may be a potential therapeutic strategy for respiratory diseases driven by oxidative stress.