NRF2 activator 
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  • ||||||||||  Journal:  Insight into the regulation of the Nrf2 pathway in response to ascovirus infection in Spodoptera exigua. (Pubmed Central) -  Nov 10, 2022   
    HvAV-3h activated Nrf2/ARE pathway of S. exigua, and ROS was found to respond to ascovirus infection by regulating the alteration of antioxidant enzyme genes mediated by the host Nrf2/ARE pathway. These findings enhance our knowledge of ascovirus-host interaction and lay the foundation for the application of ascoviruses in biological pest control.
  • ||||||||||  Journal:  Nuclear factor erythroid 2-related factor 2 and autophagy regulation in cancer development. (Pubmed Central) -  Nov 9, 2022   
    In addition to inducers that disrupt the Keap1-Nrf2 complex, defective autophagy has recently been shown to upregulate endogenous p62, which interacts with Keap1 triggering transcriptional activation of Nrf2 in several cancers. This regulation by Nrf2-dependent transactivation of cytoprotective genes needs to be validated by clinical trials in view of its persistent activation in a p62-dependent manner when there is deregulation of autophagy.
  • ||||||||||  Preclinical, Review, Journal:  NRF2 modulation in TRAMP mice: an in vivo model of prostate cancer. (Pubmed Central) -  Nov 8, 2022   
    Our work thus provides a new research avenue for the study of traditional Chinese medicine in the treatment of PCOS. We can conclude that specific natural and synthetic compounds can downregulate DNMTs and/or HDACs inhibiting the methylation status of NRF2 promoter, then reactivating the expression of NRF2 protecting normal prostatic cells from ROS damage and tumorigenesis.
  • ||||||||||  Review, Journal:  Nrf2: An all-rounder in depression. (Pubmed Central) -  Nov 8, 2022   
    Meanwhile, we summarize some natural and synthetic compounds targeting Nrf2 in depression therapy. All the above may provide new insights into targeting Nrf2 for the treatment of depression and provide a broad basis for clinical transformation.
  • ||||||||||  Preclinical, Journal:  Sulforaphane recovers cone function in an Nrf2-dependent manner in middle-aged mice undergoing RPE oxidative stress. (Pubmed Central) -  Nov 8, 2022   
    In both genotypes, SFN treatment reduced morphological markers of RPE atrophy and degeneration, although these improvements did not correlate proportionally with functional recovery. These findings highlight the capacity of SFN to preserve cone function, as well as the potential challenges of using the compound as a standalone treatment for age-related retinal degeneration under conditions associated with reduced Nrf2 function.
  • ||||||||||  Journal:  p62 bodies: phase separation, NRF2 activation, and selective autophagic degradation. (Pubmed Central) -  Nov 5, 2022   
    One is effective autophagic degradation of ubiquitinated proteins and the other is antioxidant stress response, both of which contribute to cellular homeostasis. In this review, I review the history of p62 research in relation to autophagy and outline the formation, degradation, and physiological functions of the p62 body.
  • ||||||||||  Extracellular DEK Activates NRF2 Antioxidant Targets and Drives Expansion of Functional and ROS-Low Human Hematopoietic Stem Cells (ENMCC - Hall D) -  Nov 4, 2022 - Abstract #ASH2022ASH_5647;    
    These data have important implications for the regulation of HSCs/HPCs in stress conditions, where DEK is most likely to be secreted. Further, DEK may present a novel way to mimic physiologic oxygen conditions for enhancement of functional HSC expansion, and the elucidated mechanisms may be exploited for more efficient targeting of molecular programs critical for functional HSC competency, potentially providing new ways to enhance HCT.
  • ||||||||||  azacitidine / Generic mfg.
    Re-Sensitization of Azacytidine-Resistant MDS/AML Cells Via Modulation of KEAP1-NRF2 Redox Pathway (ENMCC - Hall D) -  Nov 4, 2022 - Abstract #ASH2022ASH_4065;    
    We also demonstrated our findings of enhanced AZA efficacy by KEAP1 inhibition in vivo in an experimental CDX mouse model. This preliminary evidence supports the initiation of a randomized clinical trial to block KEAP1-NRF2 pathway in patients with high-risk-MDS progressing on AZA therapy.
  • ||||||||||  hydroxyurea / Generic mfg.
    Inhibition of MRP1 Induces Fetal Hemoglobin through NRF2 Activation to Protect Human Erythroid Cells from Sickling (ENMCC - 343-345) -  Nov 4, 2022 - Abstract #ASH2022ASH_3349;    
    In summary, we identified MRP1 as a HbF modulator in human erythroid cells and demonstrated that MRP1 inhibition induces HbF and prevents sickling of CD34+ cells through NRF2-mediated oxidative stress pathway activation without affecting erythroid differentiation, establishing MRP1 as a potential new therapeutic target for SCD. Future directions include replication of the ABCC1 genetic association in an independent cohort, and in vivo studies aiming to confirm the efficacy of MRP1 inhibition on improving SCD disease biomarkers.
  • ||||||||||  methotrexate / Generic mfg.
    Preclinical, Journal:  Methotrexate Induces an Antioxidant Hormetic Response in Primary Rat Astrocytes. (Pubmed Central) -  Nov 4, 2022   
    Our results showed that 20 nM MTX pre-conditioning for 12 h augmented the GSH/GSSG ratio and protected cellular viability against a toxic MTX and HO insult, which was abrogated when Nrf2 was inhibited by brusatol. Hence, MTX subsequent studies as a drug to counteract the progression of some stress-associated neurodegenerative diseases are suggested.
  • ||||||||||  dexmedetomidine / Generic mfg.
    Journal, IO biomarker:  Dexmedetomidine attenuates airway inflammation and oxidative stress in asthma via the Nrf2 signaling pathway. (Pubmed Central) -  Nov 3, 2022   
    To the best of our knowledge, the present study is the first to demonstrate the protective effect of DEX on Th2‑dominant asthma through the activation of the Nrf2 signaling pathway. The results suggested that the antioxidative properties of DEX could be beneficial in clinical application of DEX for the relief of asthmatic symptoms.
  • ||||||||||  Journal, IO biomarker:  Time‑dependent changes in NLRP3 and Nrf2 levels in lipopolysaccharide‑induced acute lung injury. (Pubmed Central) -  Nov 3, 2022   
    Moreover, LPS promoted Toll like receptor‑4 expression and reactive oxygen species production, thus activating NLRP3/Nrf2 signaling and pyroptosis. Collectively, the present study demonstrates that LPS triggers multiple inflammatory molecules and immune cells during ALI, which may be closely involved in the irregular redox status, NLRP3/Nrf2 pathway and pyroptosis.
  • ||||||||||  Review, Journal:  Transcription factor NRF2 as potential therapeutic target for preventing muscle wasting in aging chronic kidney disease patients. (Pubmed Central) -  Nov 3, 2022   
    Whether deficiency of nuclear factor erythroid 2-related factor 2 (NRF2), which regulates expression of antioxidant proteins protecting against oxidative damage triggered by inflammation, may exacerbate PEW has yet to be examined in aging patients with CKD. This review focuses on the hypothesis that NRF2 is involved in the maintenance of muscle mass and explores whether sustained activation of NRF2 by non-pharmacological interventions using nutraceutical activators to improve redox homeostasis could be a plausible strategy to prevent skeletal muscle disorders, including muscle wasting, sarcopenia and frailty associated with PEW in aging CKD patients.
  • ||||||||||  Journal:  Daidzein supplementation improved fecundity in sows via modulation of ovarian oxidative stress and inflammation. (Pubmed Central) -  Nov 2, 2022   
    Additionally, DAI supplementation not only increased the protein expressions of Nrf2, HO-1, and NQO1, but also decreased the protein expressions of TLR-4, p-NFκB, p-AKT, and p-IκBα. Altogether, our results indicated that DAI could ameliorate ovarian oxidative stress and inflammation in sows, which might be mediated by suppressing the TLR4/NF-κB signaling pathway and activating the Nrf2/HO-1 signaling pathway.