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17 Companies | 12 Products |
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36 Diseases | |
50 Trials |  |
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- | Journal: Trilobatin, a Natural Dihydrochalcone, Stabilizes Nrf2 to Protect the Heart from Angiotensin II-Induced Oxidative and Hypertrophic Stress. (Pubmed Central) - Aug 28, 2026
Redox Signal. 00, 000-000.
- Phenotype-dependent oxidative stress dysregulation and lipid peroxidation in X-linked adrenoleukodystrophy (Hall 4&5) - Aug 17, 2026 - Abstract #SSIEM2026SSIEM_970;
In contrast, GCLM expression was higher in CALD and asymptomatic cells. While NRF2 pathway activation represented the expected stress response in control cells, CALD fibroblasts exhibited decreased expression of NRF2 target genes relative to asymptomatic cells.
- | Journal: Investigation of Anti-Asthmatic Constituents and Mechanisms of Cimicifugae Rhizoma Based on LC-MS Analysis, Network Pharmacology and Experimental Validation. (Pubmed Central) - Jul 23, 2026
Triterpenoids in Cimicifugae Rhizoma exert anti-asthmatic effects by activating Keap1-Nrf2 pathway against oxidative stress and regulating STAT6/GATA3 pathway to balance immunity. These findings reveal the anti-asthmatic mechanism of Cimicifugae Rhizoma and suggest the potential of 'Ximingting' for further anti-asthmatic investigation.
- | sevoflurane / Generic mfg.
Journal: BMSC-derived exosomal METTL3 synergizes with Sevoflurane to inhibit ferroptosis in pulmonary ischemia/reperfusion injury by enhancing USP7 N6-methyladenosine modification. (Pubmed Central) - Jul 23, 2026
In conclusion, BMSC-derived exosomal METTL3 reinforced the protective effects of Sev by promoting USP7 mRNA translation via YTHDC2-dependent m6A modification. Upregulated USP7 subsequently facilitated Nrf2 deubiquitination, thereby inhibiting ferroptosis and protecting against pulmonary I/R injury.
- | Journal, IO biomarker: Immunomodulatory effects of ultrasonically lysed Bifidobacterium breve on Pam3CSK4-stimulated J774A.1 macrophages via SIRT1/NRF2 activation and NF-?B suppression. (Pubmed Central) - Jul 23, 2026
Reduced oxidative stress, apoptosis, and inflammatory cytokine production were associated with modulation of SIRT1, NRF2, HO-1, and NF-?B-related gene expression. These findings suggest that BB-UL may represent a promising postbiotic candidate for modulating macrophage-mediated inflammatory responses.
- | Journal: VSMC-derived 3HAA activates AhR to drive abdominal aortic aneurysm formation via the p62-Nrf2 axis. (Pubmed Central) - Jun 15, 2026
These findings suggest that BB-UL may represent a promising postbiotic candidate for modulating macrophage-mediated inflammatory responses. We conclude that 3HAA promotes AAA formation by activating AhR and suppressing p62-Nrf2-mediated mitochondrial homeostasis and targeting the kynurenine-AhR axis may offer new therapeutic strategies for treating AAA.
- Antioxidant Protective Effects Of Muscle-derived Estrogen On Skeletal Muscle (192; CC-Hall D) - Jun 1, 2026 - Abstract #ACSM2026ACSM_2511;
MdE2 promotes antioxidant enzyme activity, limits lipid peroxidation, and supports muscle repair. These findings highlight MdE2 as a key mediator of exercise-induced protection and a potential therapeutic target for muscle disorders in estrogen-deficient conditions.
- | cisplatin / Generic mfg.
Journal: Attenuating chemotherapy-induced nephrotoxicity while potentiating antitumor efficacy by transforming a Janus drug into dual-targeting carbonized polymer dots. (Pubmed Central) - May 31, 2026
Beyond conferring renoprotection, Api-CPDs enhance the antitumor efficacy of chemotherapeutics by modulating the p53 pathway. Collectively, this study demonstrates that transforming a Janus drug into bioactive carbonized polymer dots effectively overcomes the inherent limitations of small-molecule flavonoids, including poor aqueous solubility, rapid clearance, and lack of target specificity, enabling concurrent mitigation of chemotherapy-induced nephrotoxicity and potentiation of antitumor efficacy.
- | Clinical, Journal: Kukui nut oil (Aleurites moluccanus seed oil) promotes hair growth by activating the Nrf2/ARE-AKR1C family-PGF2? signaling axis. (Pubmed Central) - May 31, 2026
Furthermore, a randomized, double-blind, left-right comparison human testing confirmed the efficacy of AMS oil in promoting eyelash growth. These findings suggest that AMS oil holds promise for applications not only in promoting hair and eyelash growth but also in improving health through its antioxidant effects.
- | hydroquinone / Generic mfg.
Journal: Dual-mechanism vitamin C delivery by polyethylene glycol-23 glyceryl distearate-based niosomes via SVCT2 induction and enhanced transdermal penetration. (Pubmed Central) - May 31, 2026
Overall, this study shows that Nrf2 activation contributes to SVCT2 induction and that GDS-23 is a multifunctional DDS nanocarrier that enhances skin permeation and may promote intracellular uptake by upregulating antioxidant-related transporters. These findings highlight the therapeutic potential of combining functional nanocarriers with entrapped bioactive molecules, offering a promising strategy for efficient treatment of skin disorders and antioxidant-based interventions.
- Mechanisms and Clinical Applications of Ozone Therapy in Musculoskeletal and Spinal Disorders: A Comprehensive Review (302 & 303) - May 31, 2026 - Abstract #ISPRM2026ISPRM_115;
It may serve as an effective adjunct or alternative for patients who do not respond adequately to standard care or are poor candidates for surgery. Nevertheless, widespread adoption requires large, multicenter randomized trials with standardized dosing, longer follow up, and inclusion of both subjective and objective outcomes.
- | Journal: Mitochondrial transplantation protects the retinal pigment epithelial cells from the oxidative stress induced by NaIO3. (Pubmed Central) - May 29, 2026
In conclusion, mitochondrial transplantation could protect the RPE cells by maintaining mitochondrial homeostasis and promoting the antioxidant pathway via Nrf2 activation. This study suggests that mitochondrial transplantation could be a potential treatment option for improving AMD progress in the future.
- | Journal: ?-Resorcylaldehyde attenuates DSS-induced colitis by inhibiting inflammation and oxidative stress through the Keap1/Nrf2/HO-1 pathway. (Pubmed Central) - May 29, 2026
BRAL improves DSS-induced UC through targeting Keap1 to activate Nrf2 signaling, thereby restoring redox homeostasis, suppressing inflammation, and preserving epithelial barrier integrity. These findings suggest that BRAL is a promising natural candidate for treating UC.
- | Lorbrena (lorlatinib) / Pfizer
Preclinical, Journal: Lorlatinib protects dopaminergic neurons by inhibiting ALK-mediated neuroinflammation in a mouse model of Parkinson's disease. (Pubmed Central) - May 29, 2026
Collectively, these findings demonstrate that ALK inhibition confers neuroprotection by modulating microglia-mediated neuroinflammation. Given that LOR is a clinically approved anticancer drug with blood-brain barrier permeability, this study provides experimental evidence supporting its repositioning for the treatment of neuroinflammatory disorders, such as PD.
- | Journal: Lycopene alleviates zearalenone-induced endometrial ferroptosis in early pregnant sows by activating the Nrf2/GPX4 pathway. (Pubmed Central) - May 29, 2026
Mechanistically, LYC suppressed ferroptosis by activating the Nrf2/GPX4 pathway, upregulating the mRNA expression of GCLM, GPX4, and CP, and downregulating the protein levels of DMT1 and ACSL4. Collectively, LYC shows potential as a preventive or therapeutic strategy for ZEA-induced uterine damage.
- | doxorubicin hydrochloride / Generic mfg.
Journal: Ellagic Acid Attenuates Doxorubicin-induced Cardiomyocyte Ferroptosis Via Nuclear Factor Erythroid 2-Related Factor 2 Signaling. (Pubmed Central) - May 29, 2026
Mechanistically, these cardioprotective actions were mediated through the activation of the nuclear factor erythroid 2-related factor 2 signaling pathway. In conclusion, our findings identify ellagic acid as a novel nuclear factor erythroid 2-related factor 2 activator that protects against doxorubicin-induced cardiotoxicity by inhibiting ferroptosis in cardiomyocytes.
- | carbamazepine / Generic mfg., oxcarbazepine / Generic mfg.
Review, Journal: Trigeminal neuralgia: from clinical challenges to molecular insights. (Pubmed Central) - May 29, 2026
Current treatments primarily rely on ion channel modulators, while emerging strategies involve Nav1.7/Cav3.2 inhibitors, CGRP antibodies, NRF2 activators, and botulinum toxin. Future efforts should focus on establishing more clinically translational precision models, dissecting the spatiotemporal dynamics of neural circuits, promoting multi-target combination therapies based on molecular subtyping, and accelerating the transition from symptomatic control to curative treatment.
- acetylcysteine solution / Generic mfg.
Decellularized liver matrix hydrogels suppress hepatic stellate cell activation via ROS-independent NRF2 activation (Poster Area - Hall 7) - May 13, 2026 - Abstract #EASL2026EASL_3508;
LdECM hydrogels attenuate HSC activation by promoting a potent antioxidant program driven by the ROS-independent activation of NRF2. This finding reveals a novel mechanism where biomaterials can directly reprogram the cellular redox state to regulate HSC fate, offering a new therapeutic rationale for liver fibrosis.
- | Journal: Supercritical CO2-Derived Tomato Extract Activates Signaling Pathways to Reduce Oxidative Stress and Inflammation in Astrocyte Cells. (Pubmed Central) - May 13, 2026
These findings demonstrate that sCO2TE preserves the antioxidant and anti-inflammatory properties of tomato-derived bioactives. The comparable efficacy of sCO2TE and CTE supports the use of sCO2 as a sustainable and solvent-free extraction method for the development of nutraceutical formulations targeting oxidative stress and neuroinflammation.
- | Review, Journal: Molecular Mechanisms of Cadmium-Induced Apoptosis in Fish Cells: A Review. (Pubmed Central) - May 13, 2026
Current research gaps remain regarding dynamic pathway crosstalk, chronic low-dose effects, species differences, and fish-specific apoptotic molecules (e.g., caspase-12 homologs). Future studies should focus on constructing multidimensional response maps, clarifying pathway activation thresholds and interaction contributions, and developing composite protective strategies based on Nrf2 activators, metal chelators, and antioxidants, thereby promoting translation into ecological risk assessment and aquaculture pollution control.
- | 5-fluorouracil / Generic mfg.
Journal: Amelioration of 5-Fluorouracil-Induced Hepatorenal Toxicity by Epigallocatechin Gallate-Functionalized Selenium Nanoparticles: A Multi-Targeted Protective Approach. (Pubmed Central) - May 13, 2026
EGCG-SeNPs confer superior protection against 5-FU-induced hepatorenal toxicity compared to EGCG or inorganic selenium alone. The potent protective effects of EGCG-SeNPs are mediated through coordinated antioxidant, anti-inflammatory, and anti-apoptotic mechanisms, primarily via activation of the Nrf2/HO-1 axis and suppression of NF-?B signaling.
- | Preclinical, Journal: Celastrol Ameliorates Renal Injury in Spontaneously Hypertensive Rats by Activating the Nrf2/Ho-1 Signaling Pathway to Alleviate Oxidative Stress. (Pubmed Central) - May 13, 2026
Significantly, the mRNA levels of Nrf2, Nqo1, and Ho-1 in the CSL-treated groups were notably higher than those in the SHR group. These findings suggest that CSL mitigates renal pathological damage in SHR by activating the Nrf2/Ho-1 pathway, offering a potential therapeutic approach for hypertension-induced renal injury.
- | pyrimethamine / Generic mfg.
Journal: Pyrimethamine Restores KEAP1-Mediated Degradation of Select NRF2 Mutants in Esophageal Squamous Cell Carcinoma. (Pubmed Central) - May 13, 2026
P1
These findings show that PYR functionally restores KEAP1-mediated NRF2 degradation of select NRF2Mut through a glue-like effect and overcomes therapy resistance in ESCC. Although the proposed glue-like mechanism remains hypothetical, this work supports further investigation into the NRF2-KEAP1 interaction and may inform the development of KEAP1-targeted strategies for NRF2Mut cancers, including ESCC.
- | Journal: Intelligence-responsive wettability switch coating on magnesium implants for treating osteoporotic fracture. (Pubmed Central) - May 3, 2026
Mechanistically, single-cell transcriptomics reveals that the coating activates the nuclear factor erythroid 2-related factor 2 signaling pathway in bone marrow mesenchymal stromal cells and bone marrow-derived macrophages, enhancing osteogenesis while inhibiting osteoclastogenesis. Consequently, this multifunctional coating provides corrosion protection and a targeted therapeutic approach to enhance osteoporotic fracture healing under oxidative stress.
- | bleomycin / Generic mfg.
Journal: Anemoside B4 alleviates pulmonary fibrosis by targeting the Keap1/Nrf2 axis to suppress NLRP3 inflammasome-mediated pyroptosis and epithelial-mesenchymal transition. (Pubmed Central) - May 3, 2026
AB4 targets Keap1 to activate Nrf2-driven antioxidant responses, inhibits NLRP3-dependent pyroptosis, and attenuates secretome-driven EMT. AB4 thus presents a novel, mechanism-based candidate for clinical translation, specifically for the prevention or early intervention of progressive PF.
- sirolimus / Generic mfg.
NRF2-driven survival and antibody production in memory B cells: a therapeutic axis to reinstate humoral immunity in HIV infection (Poster Board Number 013) - May 2, 2026 - Abstract #AIDS2026AIDS_1007;
Pharmacological restoration of NRF2 activity offers a viable strategy to enhance humoral immunity, improve vaccine responses, and reduce susceptibility to co-infections. Targeting NRF2-dependent pathways could complement ART, moving toward full immune reconstitution and durable protection for people living with HIV.
- | hydroquinone / Generic mfg.
Preclinical, Journal: Discovery of novel tert-butylhydroquinone derivatives as potential anti-endothelial injury agents: Synthesis, in vitro, and in vivo evaluation. (Pubmed Central) - May 1, 2026
Targeting NRF2-dependent pathways could complement ART, moving toward full immune reconstitution and durable protection for people living with HIV. Tert-butyl hydroquinone (tBHQ) is widely used as a food additive due to its superior protective properties, making it a valuable component in the food, cosmetic, and pharmaceutical industries...The protective mechanisms of compound 3
- | Preclinical, Journal: Oxidative Stress in Keratoconus Is Evident in Tear Fluid and Stromal Cells and Alleviated in Cell Culture by Sulforaphane. (Pubmed Central) - May 1, 2026
NRF2-mediated anti-oxidative functions are dysregulated in KC. In the future SFN antioxidant treatments may be therapeutic in KC, while MDA and GPX3 may lead to promising biomarkers for diagnosis and severity predictions.
- | Review, Journal: Quercetin in skin burn healing: mechanisms, advanced delivery systems, and translational perspectives. (Pubmed Central) - May 1, 2026
By integrating pharmacodynamics, formulation science, and clinical feasibility, the article clarifies current evidence gaps and outlines practical directions for therapeutic development. Such synthesis is timely because research on flavonoid-based wound therapeutics is expanding rapidly but remains fragmented across disciplines.
- | Journal: Gallium-Doped Mesoporous Bioactive Glass Nanoparticles for Antibacterial and Immunomodulatory Effects in Vital Pulp Therapy. (Pubmed Central) - Apr 26, 2026
This controlled ion delivery also promotes odontogenic differentiation and dentin matrix formation, ultimately preserving pulp vitality in vivo. By integrating antimicrobial, immunoregulatory, and regenerative capabilities within a single nano-engineered platform, this study introduces a structurally defined and functionally active biomaterial with clear potential to advance vital pulp therapy and regenerative dental medicine.
- | Stendra (avanafil) / IEH Biopharma, Menarini, Endo
Journal: Therapeutic Repurposing of Avanafil Against Lipopolysaccharide-induced Depression and Autoimmune Hepatitis: Gut-brain-liver Axis Orchestration Via Regulation of TLR4/NF-?B/IDO and Nrf2/HO-1 Pathways. (Pubmed Central) - Apr 26, 2026
Mechanistically, AVA downregulated the TLR4/NF-?B/IDO pathway, restored serotonin levels, reduced quinolinic acid accumulation, and activated the Nrf2/HO-1 signaling cascade in both hippocampal and liver tissues. These findings suggest that AVA exerts neuroprotective and hepatoprotective effects by modulating intestinal permeability, inflammation, and oxidative stress, making it a promising therapeutic candidate for conditions associated with systemic inflammation such as MDD and AIH.
- | Review, Journal: Polyphenols and physical activity stimulate gut microbiota mediated Nrf2 signaling to combat neurodegeneration. (Pubmed Central) - Apr 26, 2026
Finally, we address translational challenges and highlight the potential of integrating dietary and exercise-based strategies to harness microbiota-dependent Nrf2 activation. This integrative framework provides a basis for developing personalized, microbiome-informed interventions aimed at delaying or mitigating neurodegeneration.
- | metformin / Generic mfg.
Journal: 4-HNE induces cell death through the VCP-related ubiquitination pathway in diabetic cardiomyopathy and the protective effect of metformin. (Pubmed Central) - Apr 26, 2026
Our results show that 4-HNE directly binds to VCP and disrupts its signaling pathway, induces ubiquitination accumulation, which ultimately leads to cardiomyocyte death, providing a new mechanism for the cardiac injury of 4-HNE. Meanwhile, metformin effectively alleviates 4-HNE induced ubiquitination and cell death in cardiomyocytes and diabetic cardiomyopathy models, and improves cardiac function, demonstrating potential therapeutic effects.
- | Preclinical, Journal: Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes Preserve Melanocyte Stem Cell Integrity Under Acute Neurogenic Oxidative Stress via Activation of the Nrf2-ARE Pathway in C57BL/6J Mice. (Pubmed Central) - Apr 24, 2026
Meanwhile, metformin effectively alleviates 4-HNE induced ubiquitination and cell death in cardiomyocytes and diabetic cardiomyopathy models, and improves cardiac function, demonstrating potential therapeutic effects. HUCB-MSC-Exo alleviates acute neurogenic oxidative stress and preserves melanocyte function by activating the Nrf2-ARE pathway, thereby mitigating stress-induced hair depigmentation in C57BL/6J mice.
- | selisistat (SEN-196) / AOP Orphan Pharma
Journal: Diosmetin improves myocardial ischemia/reperfusion injury via activation of the SIRT1/NRF2 axis. (Pubmed Central) - Apr 24, 2026
HUCB-MSC-Exo alleviates acute neurogenic oxidative stress and preserves melanocyte function by activating the Nrf2-ARE pathway, thereby mitigating stress-induced hair depigmentation in C57BL/6J mice. Our findings demonstrate that Dios ameliorates myocardial I/R injury by reducing oxidative stress, inflammation, DNA damage, and apoptosis via activating the SIRT1/NRF2 pathway.
- | Journal: Targeting ME1 rescues redox-metabolic coordination in ALS: A core effector of NRF2-directed therapy. (Pubmed Central) - Apr 24, 2026
Loss-of-function experiments confirmed that ME1 knockdown abolished the protective effects, indicating that the NRF2-ME1 axis is a central hub for the synergistic regulation of metabolic and oxidative homeostasis. In conclusion, MKL01351 concurrently ameliorates oxidative stress and metabolic dysregulation via the NRF2-ME1 signaling pathway, offering a novel neuroprotective strategy for ALS treatment.
- | Preclinical, Journal, IO biomarker: ?-sitosterol attenuates hyperglycemia induced apoptosis through modulating NF-?B/NLRP3 in renal proximal tubule epithelial cell line. (Pubmed Central) - Apr 24, 2026
?-sitosterol also effectively prevented high glucose-mediated apoptosis in HK-2 renal cells. ?-sitosterol exhibits nephroprotective effects through modulation of inflammatory, oxidative stress, survival, and apoptotic pathways, representing a promising therapeutic candidate for diabetic nephropathy.
- | Review, Journal: Targeting Mitochondrial Quality Control in Alzheimer's Disease: Mechanisms and Therapeutic Potential of Phytomedicines. (Pubmed Central) - Apr 24, 2026
Despite these promising preclinical findings, several challenges remain, including poor bioavailability, limited blood-brain barrier penetration, lack of standardized preparations, and insufficient clinical validation. This review provides a mechanistic rationale for targeting MQC in AD and highlights future directions for translating phytochemical-based strategies into effective therapies.
- | Journal: Zinc deficiency exacerbates and supplementation attenuates early-stage obesity-related podocyte injury via Nrf2/HO-1-mediated pyroptosis. (Pubmed Central) - Apr 24, 2026
Notably, the renoprotective effects of zinc were markedly attenuated in Nrf2-knockdown mice and in podocytes treated with an Nrf2 inhibitor ML385, supporting a functional role of Nrf2 signaling in mediating these effects. Collectively, our findings suggest that zinc supplementation alleviates ORG, at least in part, by modulating the Nrf2/HO-1-NLRP3 inflammasome-associated pyroptosis signaling in podocytes.
- | Journal: Curcumin Alleviates Myocardial Ischaemia-Reperfusion Injury by Inhibiting NLRP3 Inflammasome Activation and Pyroptosis via the Nrf2/HO-1 Pathway: An Integrated Network Pharmacology and Experimental Study. (Pubmed Central) - Apr 24, 2026
Collectively, our findings suggest that zinc supplementation alleviates ORG, at least in part, by modulating the Nrf2/HO-1-NLRP3 inflammasome-associated pyroptosis signaling in podocytes. Combining in silico and experimental evidence, Cur attenuates MIRI by activating Nrf2/HO-1 to inhibit NLRP3 inflammasome-mediated pyroptosis.
- | dimethyl fumarate / Generic mfg.
Journal: Macrophage-Targeted Nanocarriers Based on Tetrahedral DNA Nanostructure Alleviate Sepsis-Induced Acute Lung Injury by Triple-Pathway Suppression of Pyroptosis. (Pubmed Central) - Apr 19, 2026
Mechanistically, T-D@TDN integrates a triple-regulation strategy to suppress pyroptosis: the TDN framework exerts intrinsic ROS-scavenging activity, while the released DMF activates the NRF2/HO-1 axis to further eliminate intracellular ROS and directly inhibits GSDMD cleavage. Collectively, these findings demonstrate that T-D@TDN functions as a multifunctional inhalable nanotherapeutic agent capable of multidimensionally regulating oxidative stress and pyroptosis pathways, providing a promising noninvasive strategy for the treatment of SI-ALI and related inflammatory lung diseases.
- | dimethyl fumarate / Generic mfg.
Journal: Nrf2 modulates the IRF7-SLC31A1 axis to suppress neuronal cuproptosis after traumatic brain injury. (Pubmed Central) - Apr 19, 2026
The Nrf2 activator dimethyl fumarate (DMF) suppresses neuronal injury and improves neurological function in TBI mice by inhibiting cuproptosis. Our results establish that cuproptosis is an important mechanism in TBI and that activation of Nrf2 mitigates TBI-induced cuproptosis by regulating the IRF7-SLC31A1 axis.
- | Journal: Nrf2 attenuates epithelial-mesenchymal transition of lens epithelial cells in fibrotic cataract via PINK1-mediated mitophagy. (Pubmed Central) - Apr 19, 2026
We found that Nrf2 directly binds to the PINK1 promoter to drive its transcription. Collectively, our study suggests that Nrf2 activation mitigates lens fibrosis by promoting PINK1-dependent mitophagy, identifying the Nrf2-PINK1 axis as a potential therapeutic target.
- | Journal: Morusin attenuates myocardial ischemia/reperfusion injury by inhibiting ferroptosis via dual activation of the Nrf2/HO-1 pathway and mTORC1-dependent GPX4 synthesis. (Pubmed Central) - Apr 19, 2026
These findings reveal that morusin mitigates MIRI by dual modulation of ferroptosis through Nrf2/HO-1-mediated antioxidative responses and mTORC1-dependent GPX4 upregulation. This study highlights morusin's therapeutic potential for ischemic heart diseases, offering novel insights into targeting ferroptosis for cardioprotection.
- | Preclinical, Journal: GC-MS phytochemical screening, molecular docking, MD simulation, and in vitro antioxidant assay of Euphorbia thymifolia L. extract. (Pubmed Central) - Apr 19, 2026
The present study shows that Euphorbia thymifolia L. includes bioactive compounds with significant antioxidant activity, as evidenced by in vitro experiments and Keap1-Nrf2 pathway interactions discovered in silico. The stable ligand-protein interaction shows that it has potential as a natural source for antioxidant therapy development and should be investigated further.
- Urece (dotinurad) / Fuji Yakuhin, Mochida, Fortress, Eisai
Dotinurad Exerts Direct Renal Tubular Protection via Nrf2-Mediated Mitochondrial Quality Control Independent of URAT1 Inhibition (Research Zone) - Apr 13, 2026 - Abstract #ERA2026ERA_3043;
Crucially, these renoprotective effects occurred without significant changes in serum uric acid levels compared to the model group Conclusion Dotinurad confers direct protection against renal tubular injury and fibrosis via a dual mechanism involving Nrf2 activation and mitophagy restoration. These findings reposition Dotinurad as a potential therapeutic agent for CKD targeting mitochondrial quality control, independent of its URAT1-inhibitory activity
- | Journal: 4-Methylcatechol prevents deoxynivalenol-induced claudin-4 internalization and restores barrier integrity via Nrf2 activation. (Pubmed Central) - Apr 12, 2026
In the piglet model, DON exposure caused villus atrophy, fusion, and epithelial necrosis, whereas dietary 4-MC alleviated these histopathological lesions. Overall, the findings demonstrate that 4-MC significantly mitigates DON-induced intestinal epithelial damage through mechanisms largely dependent on Nrf2 activation, supporting its potential as a dietary strategy to protect intestinal health.
- | Review, Journal: Recent advances in polymeric nanoparticle-mediated drug delivery system across the blood-brain barrier in Alzheimer's disease. (Pubmed Central) - Apr 12, 2026
Addressing these issues will require interdisciplinary collaboration among materials science, neurobiology, pharmaceutical technology, and clinical research. Overall, this review highlights recent progress, therapeutic mechanisms, and the growing promise of PNP-based brain-targeted nanomedicine as a transformative approach for AD treatment.
- | Journal: 3D-printed PLA/?-TCP scaffold functionalized with PDA and neobavaisoflavone-loaded PEG hydrogel for enhanced bone repair. (Pubmed Central) - Apr 12, 2026
In vivo evaluation using a rat skull defect model demonstrated that the PT/PDA/PEG/NB scaffolds significantly enhanced bone repair compared with control scaffolds. Collectively, this multifunctional scaffold integrates immunomodulation, antioxidative defense, and osteoinduction, offering a promising platform for effective bone defect repair and advanced orthopedic implant design.
- | HibTITER (diphtheria crm197 protein conjugate) / Nuron Biotech, Mitsubishi Tanabe
Journal: Covalent modification of Keap1 Cys489 by NU6300 activates Nrf2 signaling and suppresses NLRP3 inflammasome-mediated pyroptosis. (Pubmed Central) - Apr 10, 2026
In vivo, NU6300 exhibits potent antioxidant and anti-inflammatory protection against acetaminophen (APAP)-induced acute liver injury in mice. Collectively, these findings demonstrate that NU6300 is a novel Nrf2 activator and offers a promising therapeutic strategy for pyroptosis-driven inflammatory diseases.