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- | Journal: Limonin inhibits the stemness of cancer stem-like cells derived from colorectal carcinoma cells potentially via blocking STAT3 signaling. (Pubmed Central) - Mar 8, 2024
Taken together, these results indicate that limonin is a promising compound that targets CSCs and could be used to combat CRC recurrence and metastasis.
- | Journal: Quality and applicability of cadaveric donor eyes for molecular biology research: An Indian experience. (Pubmed Central) - Mar 8, 2024
Taken together, these results indicate that limonin is a promising compound that targets CSCs and could be used to combat CRC recurrence and metastasis. The cadaver donor tissues collected within 24 hours of death can be effectively utilized for gene expression profiling.
- | Journal: Exogenous betaine enhances salt tolerance of Glycyrrhiza uralensis through multiple pathways. (Pubmed Central) - Mar 7, 2024
The cadaver donor tissues collected within 24 hours of death can be effectively utilized for gene expression profiling. In summary, the exogenous addition of GB significantly enhances the salt tolerance of G. uralensis seedlings, promoting osmoregulatory substances, antioxidant enzyme activities, excess salt discharge especially the significant promotion of the secretion of Na+Future studies should aim to elucidate the molecular mechanisms that operate when GB regulates saline stress tolerance.
- | Journal: Comprehensive analysis of the aldehyde dehydrogenase gene family in Phaseolus vulgaris L. and their response to saline-alkali stress. (Pubmed Central) - Mar 7, 2024
The influence of PvALDHs potentially modulates abiotic stress response, particularly in the context of saline-alkali stress. These findings establish a basis for future research into the potential roles of ALDHs in the common bean.
- | Journal, Cancer stem: The role of telocytes and miR-21-5p in tumorigenicity and metastasis of breast cancer stem cells. (Pubmed Central) - Mar 6, 2024
These findings establish a basis for future research into the potential roles of ALDHs in the common bean. In our study, by gene/protein level analysis we demonstrated that telocytes may have the potential to reduce cancer metastasis through miR-21-5p in breast cancer progression and reduce EMT transition.
- | Journal, Immune cell: Mitochondrial-related genes PDK2, CHDH, and ALDH5A1 served as a diagnostic signature and correlated with immune cell infiltration in ulcerative colitis. (Pubmed Central) - Mar 6, 2024
Then, immunofluorescence analysis confirmed the augmented expression of CD86 in the tissue of mice subjected to DSS, while a diminished expression of ALDH5A1, CHDH, and PDK2 was observed. Consequently, it can be inferred that targeting mitochondria-associated genes, namely PDK2, CHDH, and ALDH5A1, holds potential as a viable strategy for prognostic prediction and the implementation of immune therapy for UC.
- | Journal: Development of substituted benzimidazoles as inhibitors of human aldehyde dehydrogenase 1A isoenzymes. (Pubmed Central) - Mar 6, 2024
Optimization of the CM10 scaffold, aided by ALDH1A1 crystal structures, led to improved biochemical potencies, improved cellular efficacy as demonstrated by reduction in ALDEFLUOR signal in HGSOC cells, and substantial improvements in liver microsomal stability. Based on this work we identified two compounds 17 and 25 suitable for future in vivo proof of concept experiments.
- SLC1A4 is associated with metabolic reprogramming in triple-negative breast cancer (Section 14) - Mar 5, 2024 - Abstract #AACR2024AACR_9652;
Taken together, SLC1A4 is a potential oncogene that not only induces rapid proliferation, aggressive invasion, and migration through metabolic reprogramming but also contributes to increasing cancer stem cell capabilities. In addition, it shows the sensitive response to ADR when SLC1A4 is low or absent, so it can be used as a treatment strategy for TNBC.
- Venclexta (venetoclax) / Roche, AbbVie
Isatin analogs potentiate the cytotoxicity of venetoclax in acute myeloid leukemia cells (Section 26) - Mar 5, 2024 - Abstract #AACR2024AACR_9289;
Furthermore, our aim will be to demonstrate activity in primary patient cells along with preclinical efficacy in AML animal models. To summarize, in vitro findings showed synergetic cooperation between ISA and VEN in combination for effective induction of apoptosis and anti-leukemic activity in AML cells that are sensitive and resistant to VEN.
- Transformative pathomics in oncology: Harnessing FFPE tissue slide imagery for clinically relevant gene expression prediction in invasive breast carcinoma (Section 51) - Mar 5, 2024 - Abstract #AACR2024AACR_8911;
To summarize, in vitro findings showed synergetic cooperation between ISA and VEN in combination for effective induction of apoptosis and anti-leukemic activity in AML cells that are sensitive and resistant to VEN. Abstract is embargoed at this time.
- AXIN2 differentially modulates stem cell subpopulations providing a potential therapeutic opportunity for targeting colorectal cancer stem cells (Section 8) - Mar 5, 2024 - Abstract #AACR2024AACR_8648;
It also promotes the RA-signaling component expression - a pathway known to regulate SC differentiation. As a potential treatment strategy for CRC, therapeutically inducing high levels of AXIN2 could shift the balance between SC populations towards ALDH+ SCs, which may provide a way to target cancer SCs with retinoids to induce their differentiation.
- Down regulation of cysteine glutamate antiporter in ALDH1A1 expressing oral and breast cancer stem cells induced oxidative stress triggered ferroptosis (Section 8) - Mar 5, 2024 - Abstract #AACR2024AACR_8638;
As a potential treatment strategy for CRC, therapeutically inducing high levels of AXIN2 could shift the balance between SC populations towards ALDH+ SCs, which may provide a way to target cancer SCs with retinoids to induce their differentiation. In the present study, we demonstrate that SAS potentially induced ferroptosis accompanied with oxidative stress in both OCSCs as well as BCSCs by lowering GPx 4 activity, a key enzyme that scavenges the products produced as a result of oxidative stress.
- TM4SF1 maintains cancer stemness in cholangiocarcinoma (Section 8) - Mar 5, 2024 - Abstract #AACR2024AACR_8637;
In addition, the results from flow cytometry and RT-PCR showed a corresponding decrease in CD24 and CD133 expression with TM4SF1 knockdown when comparing to TM4SF1 wild type. In conclusion, TM4SF1 is associated with the stemness of CCA and could be a therapeutic target for CCA therapy to overcome therapy resistance in future.
- temozolomide / Generic mfg.
Metastasis-enhancing protein KITENIN confers temozolomide resistance in glioblastoma with unmethylated MGMT via upregulation of cancer stem cell makers (Section 8) - Mar 5, 2024 - Abstract #AACR2024AACR_8636;
KITENIN might contribute to TMZ resistance in GBM patients with unmethylated MGMT, potentially through AP-1 activation and subsequent upregulation of CSC markers. Hence, targeting KITENIN could provide a novel strategy to overcome TMZ resistance in GBM patients with unmethylated MGMT.
- CUEDC2 involved in the inhibitory effect of dandelion on triple-negative breast cancer stem cells (Section 8) - Mar 5, 2024 - Abstract #AACR2024AACR_8632;
CUEDC2 played a crucial role in maintaining the stem cell properties of TNBC. DE inhibit the self-renewal of TNBC stem cells by regulating the CUEDC2 related signaling pathway.
- Discovery of CYP26A1 as a link between WNT and retinoic acid signaling pathways that modulates retinoid-induced differentiation of APC-mutant colorectal cancer cells (Section 8) - Mar 5, 2024 - Abstract #AACR2024AACR_8627;
Thus, by inducing wt-APC expression and exogenously activating RA signaling, we found a way to increase differentiation of SCs along the NEC (and other) lineage(s). Translating this strategy in vivo might lead to new, more effective treatments involving retinoids for CRC patients.
- FOSL1 promotes glioma tumorigenesis and stemness through NF-?B and STAT3 pathways (Section 6) - Mar 5, 2024 - Abstract #AACR2024AACR_8571;
Translating this strategy in vivo might lead to new, more effective treatments involving retinoids for CRC patients. The FOSL1 molecular pathway is functionally connected to NF-?B and STAT3 activation, enhances stemness, and FOSL1 is a novel GBM drug target.
- Role of HOX gene expression in differentiation of colon cancer stem cells (Section 13) - Mar 5, 2024 - Abstract #AACR2024AACR_8483;
Bioinformatics analysis predicted that these HOX genes (plus HOXA4, HOXA10, HOXC8) are regulated by RA signaling. Accordingly, we studied how ATRA influences HOX expression in CRC cells (HT29 & SW480).
- albumin-bound paclitaxel / Generic mfg., gemcitabine / Generic mfg.
Disulfiram and its metal complexes reversed hypoxia induced stemness and synergized with first line drugs in primary patient derived pancreatic ductal adenocarcinoma cells (Section 24) - Mar 5, 2024 - Abstract #AACR2024AACR_8062;
Alb-CuDDC targets CSCs and overcomes resistance in PDAC, similar to free DSF-Cu. Alb-ZnDDC may have alternative mechanisms which are yet to be elucidated.
- gemcitabine / Generic mfg.
ALDH3A1 as a predictive marker for gemcitabine treatment in pancreatic cancer (Section 24) - Mar 5, 2024 - Abstract #AACR2024AACR_8061;
Alb-ZnDDC may have alternative mechanisms which are yet to be elucidated. In this study, we demonstrated the negative correlation between ALDH3A1 and gemcitabine resistant in pancreatic cancer cell lines and suggesting that it may serves as a predictive marker for gemcitabine treatment in pancreatic cancer patients.
- Developing a novel humanized anti-FABP4 antibody for breast cancer treatment (Section 25) - Mar 5, 2024 - Abstract #AACR2024AACR_8035;
Notably, the humanized variant, 12G2-variant 9 (12G2-vt9), effectively inhibited mammary tumor growth and progression by reducing the activity of FABP4/ALDH1 in different breast cancer mouse models. Our findings suggest that 12G2-Vt9 is a promising neutralizing mAb targeting FABP4-mediated cancer stemness through ALDH1 signaling, offering potential as a targeted therapeutic antibody for the clinical treatment of breast cancer.
- Early-onset CRC, vitamin A deficiency, and stem cell origin of cancer (Section 36) - Mar 5, 2024 - Abstract #AACR2024AACR_7543;
We previously reported that RA signaling mainly occurs in aldehyde dehydrogenase-positive (ALDH+) SCs and that APC mutation leads to overpopulation of ALDH+ SCs and incomplete differentiation during CRC development. Thus, our findings suggest that APC mutation attenuates RA signaling in ALDH+ SCs, which might explain how vitamin A deficiency contributes to EOCRC development.
- Establishing CAF-like and TAM-like transformation induced by TNBC culture supernatant in 3D in-vitro culture as a model for targeted drug testing (Section 10) - Mar 5, 2024 - Abstract #AACR2024AACR_7448;
To further investigate, a series of experiments using mono- and co-cultures of these cells are underway, specifically targeting the transformed macrophages and fibroblasts with the aim of either re-educating or eliminating them. This treatment involves drug combinations that specifically target the identified signaling pathway intermediates, offering novel therapeutic intervention strategies.
- AZD5991 / AstraZeneca, Koselugo (selumetinib) / Merck (MSD), AstraZeneca
Combined inhibition of MCL-1 and MEK reduces tumor growth in a triple-negative/inflammatory breast cancer, MEK-resistant xenograft mouse model (Section 27) - Mar 5, 2024 - Abstract #AACR2024AACR_6791;
Further, we treated resistant cells with MEKi AZD6244 and an MCL-1i (AZD5991) that confirmed restoration of MEK sensitivity in both resistant cell lines, resulting in decreased cell viability, colony formation and increased apoptosis. Our results suggest that MCL-1 is important for inducing acquired MEK resistance and combining an MCL-1i with a MEKi could improve treatment outcomes of patients with TNBC or IBC who have developed resistance to single-agent MEKi.
- Talzenna (talazoparib) / Pfizer
Identification of a novel agnostic predictive multiomic signature via Elastic Net/Machine Learning in TALAPRO-2 (TP-2), a phase 3 study of talazoparib (TALA) + enzalutamide (ENZA) vs placebo (PBO) + ENZA as first-line (1L) treatment in patients (pts) with metastatic castration-resistant prostate cancer (mCRPC) (Section 50) - Mar 5, 2024 - Abstract #AACR2024AACR_6674;
Our results suggest that MCL-1 is important for inducing acquired MEK resistance and combining an MCL-1i with a MEKi could improve treatment outcomes of patients with TNBC or IBC who have developed resistance to single-agent MEKi. Abstract is embargoed at this time.
- Immunological targeting of integrin ?1high/?3high melanoma (Section 8) - Mar 5, 2024 - Abstract #AACR2024AACR_5972;
On-going experiments include the investigation of experimental evidence to verify that ITGB1 and ITGB3-targeted vaccines have induced targeting of ITGB1high/ITGB3high melanoma CSCs; and both the cellular and humoral mechanisms underlining the anti- ITGB1high/ITGB3high melanoma CSC immunity. At the same time, generation and use of ITGB2 deficient DCs for the vaccine preparation to improve the efficacy of DC vaccine targeting integrin ITGB1high/ITGB3high melanoma and melanoma CSCs warranty further investigation.
- Heme oxygenase 1 pulls the brake on stemness-induced properties by prostate cancer-bone crosstalk (Section 8) - Mar 5, 2024 - Abstract #AACR2024AACR_5971;
We also performed multiple survival analyses including progression-free, metastasis-free, biochemical relapse-free and overall survival (TCGA-PRAD, GSE116918, GSE70770) which revealed that CD44 expression is associated with increased risk of metastasis (p<0.05), while patients with high expression of SOX2, ALDH1B1 and ALDH1L2 showed shorter times to biochemical relapse (p<0.05) Altogether, HO-1 expression modulates stemness and metastasis-related genes in PCa cells, steering tumor cells towards a more differentiated state and counteracting the pro-stemness effect inherent to the communication with bone progenitors. These findings support the antitumoral role of HO-1 in PCa and underscores CD44 as an HO-1-modulated compelling candidate for further investigations.
- The significance of TIMP-1 and hypoxia in cancer stemness: A synergistic role in chemoresistance (Section 8) - Mar 5, 2024 - Abstract #AACR2024AACR_5963;
Furthermore, we determined the mRNA levels of CD44, another CSC marker also expressed in lung cancer is upregulated under hypoxia (1% O2) in both the NT and KD clones of TIMP1. Thus, we postulate that TIMP1 enhances chemoresistance by promoting CSC propagation within a hypoxic tumor microenvironment.
- A potential oncogenic role and immunoregulatory mechanisms of MZB1 in melanoma (Section 25) - Mar 5, 2024 - Abstract #AACR2024AACR_5390;
Overall, our study suggests MZB1 promotes oncogenic signaling in melanoma to drive proliferation and dedifferentiation, as well as regulates a wide range of immune-related genes that may be responsible for immune evasion in melanoma cells. Thus, MZB1 merits further investigation to determine if the immune consequences yielded by targeting MZB1 can complement ICB approaches in the management of melanoma.
- oxaliplatin / Generic mfg.
A novel signaling axis of APE1-redox-sensitive SOX9 activation underlying reflux-condition-associated chemoresistance in esophageal adenocarcinoma (Section 26) - Mar 5, 2024 - Abstract #AACR2024AACR_5356;
Cell models, patient tissue arrays, pL2-IL1? transgenic mice, and de-identified xenografts derived from EAC patients (PDXs) were employed to investigate the signaling axis of APE1-redox-SOX9 in oxaliplatin resistance of EAC...This study sheds light on a novel signaling axis involving APE1-redox-AKT-GSK3
- Cancer metastasis and stemness: The metastasis-inducer MACC1 regulates LGR5 to promote cancer stem cell-like properties in colorectal cancer (Section 10) - Mar 5, 2024 - Abstract #AACR2024AACR_4586;
Taken together, this study indicates that the metastasis-inducer MACC1 act as a cancer stem cell-associated marker. Interventional approaches targeting MACC1 would potentially improve further targeted therapies for colorectal cancer patients to eradicate CSCs, prevent cancer recurrence and distant metastasis formation.
- Exposure of arsenic promotes malignant stemness and induces bladder malignancy in preclinical models (Section 7) - Mar 5, 2024 - Abstract #AACR2024AACR_4553;
We have also observed similar molecular signatures (MTF1 and ALDH1A1 expression) in arsenic-exposed versus non-exposed mice and bladder cancer patients. In conclusion, our studies suggest that activation of stem cells is a critical step in arsenic-induced bladder carcinogenesis.
- ALDH2 deficiency and alcohol intake: Opportunity for precision cancer prevention (Section 33) - Mar 5, 2024 - Abstract #AACR2024AACR_4472;
Our study shows that ALDH2 deficiency is fairly common among Asian Americans and that many affected individuals still drink alcohol. With the growing population of Asian Americans in the U.S. (currently >7% of the total U.S. population, projected to be ~38 million individuals by 2050), our findings suggest a significant opportunity for precision cancer prevention for a substantial portion of the population.
- NT219 / Purple Biotech
NT219, a dual inhibitor of IRS1/2 and STAT3, suppresses cancer stem cell mediated resistance to KRASG12C and KRASG12D inhibitors in solid tumors (Section 24) - Mar 5, 2024 - Abstract #AACR2024AACR_4025;
Initial results suggest involvement of NT219 target proteins in resistance to mKRASG12C/D inhibitors. Treatment with sotorasib induced enhancement in stemness potential of mKRASG12C NSCLC, which NT219 efficiently suppressed, suggesting a novel therapy for this unmet need and a novel mechanism to combat resistance to mKRAS inhibitors
- Targeting chromatin in ovarian cancer stem cells (Section 46) - Mar 5, 2024 - Abstract #AACR2024AACR_3834;
In conclusion, OCSCs harbor highly packed chromatin, contributing to chemoresistance and cell plasticity. Epigenetic modifiers (such as Dot1Li) inhibit stemness by regulating chromatin organization and transcriptional malleability.
- CD133 expression is associated with less DNA repair, better response to chemotherapy, and survival in ER-positive/ER-negative breast cancer (Section 44) - Mar 5, 2024 - Abstract #AACR2024AACR_3667;
Epigenetic modifiers (such as Dot1Li) inhibit stemness by regulating chromatin organization and transcriptional malleability. CD133-high ER+/HER2- BC is associated with CSC phenotype, reduced cell proliferation, and impaired DNA repair, but enhanced inflammation, potentially explaining the better response to NAC and favorable patient prognosis.
- The Oxford Classic can identify HGSOC patients who may benefit from EMT-targeting therapies (Section 43) - Mar 5, 2024 - Abstract #AACR2024AACR_3641;
1) The Oxford Classic-based EMT is a robust prognostic biomarker of overall survival in HGSOC, that faithfully represents the complex circuitry of pathways which are a hallmark of Epithelial to Mesenchymal Transition. 2) OxC-EMT risk stratification can identify HGSOC patients who may benefit from EMT-targeting therapies.Reference: 1) Hu Z. Cancer Cell 2020 2) Hu Z. Clin Cancer Res 2021 3) Hollis R. Clin Cancer Res 2022
- Optimization of Lin28 inhibitors: A promising therapeutic approach for the suppression of cancer cell proliferation, stemness properties, and spheroid growth (Section 20) - Mar 5, 2024 - Abstract #AACR2024AACR_3594;
We discovered a novel Ln15 derivative named Ln268, which has a better metabolism profile and increased inhibitory activity to distrust Lin28-Let7 interaction and cancer cell proliferation. Ln268 has the potential to be improved and used as an anti-cancer treatment for a variety of malignancies, such as prostate cancer.
- The effects of retinoid agents and retinoic acid receptor genotype on proliferation, differentiation, and stem cells in colorectal cancer (Section 10) - Mar 5, 2024 - Abstract #AACR2024AACR_3222;
Overall, our findings indicate that colon SCs are regulated by RA signaling mechanisms and dysregulation of RA signaling contributes to the SC overpopulation that drives CRC growth. Thus, therapeutically sensitizing CSCs to differentiation-inducing effects of retinoid agents should provide insight into designing new SC-targeted therapies for CRC.
- Fusobacterium nucleatum in saliva of oral cancer patients induces tumor stemness defense phenotype in cancer stem cells (Section 4) - Mar 5, 2024 - Abstract #AACR2024AACR_2857;
Importantly presence of live bacteria in ABCG2+ CSCs indicates that FN selectively infects ABCG2+ CSCs but not ABCG2- cells. High clonogenicity of ABCG2+ CSCs confirms the TSD phenotypic attributes of the CSCs.
- napabucasin (BBI608) / Sumitomo Pharma
NCX 4040 and napabucasin synergistically inhibits stemness in human prostate cancer (PCa) cellular models and potently targets transgenic murine PCa cells via inducing oxidative stress (Section 39) - Mar 5, 2024 - Abstract #AACR2024AACR_2494;
By investigating the ROS production, cell death and cell cycle mechanism using flow cytometric analysis, it was observed that the combination therapy synergistically induces cellular oxidative stress which causes cancer cells to undergo late apoptosis and halts the growth of Myc-Cap cells in G2M phase of cell cycle. In conclusion, our data suggests that combination therapy of NCX 4040 and napabucasin can be potential treatment strategy for PCa warranting further evaluation in in vivo models.
- tamoxifen / Generic mfg.
The impact of tamoxifen on autophagic and epigenetic regulation in endometrial cancer (Section 41) - Mar 5, 2024 - Abstract #AACR2024AACR_2386;
Our findings demonstrate tamoxifen's influence on cellular and molecular pathways, highlighting the complex interplay between drug treatment and cancer progression. The observed epigenetic changes provide insight into the mechanisms by which tamoxifen may contribute to endometrial cancer risk, suggesting potential targets for therapeutic intervention.
- Buccal mucosal remodeling predicts esophageal cancer risk (Section 43) - Mar 5, 2024 - Abstract #AACR2024AACR_2353;
The prediction model for ESCC using sequencing data outperformed a model using self-reported lifestyle and alcohol flushing reaction and a model using lifestyle and germline risk variants (AUC of 0.94, 0.72, and 0.88, respectively). In conclusion, this is the first study to use clonal expansion in normal tissues to predict the presence of solid organ cancer, and our study successfully established a prediction model for ESCC based on buccal mucosal remodeling and germline variants.
- Development of non-smoking lung cancers by indoor carcinogenic aerosols through epigenetic reprogramming of lung stem cells: Bioinformatics and artificial intelligence analysis. (Section 36) - Mar 5, 2024 - Abstract #AACR2024AACR_2194;
The heterogenic adult stem cell reprogramming is regulated by epigenetic bivalent histone modifications at transcript starts sequences (TSS) of target genes and our current study revealed that CD44, CD80, ALDH2, ALDH3A1, ALDH3B2 are epigenetically reprogrammed with close interaction of other genes by these toxic ingredients of indoor aerosols. Therefore, our results are significant for the carcinogenic effects of indoor aerosols causing for development of lung cancer epigenetically, which may give a clue for the prevention and treatment of nonsmoking lung cancer.
- | Journal: A functional variant of ALDH1A2 is associated with hand osteoarthritis in the Chinese population. (Pubmed Central) - Mar 5, 2024
Variant rs12915901 of ALDH1A2 contributed to the susceptibility of HOA in the Chinese population. Allele A of rs12915901 can add to the risk of HOA possibly via down-regulation of ALDH1A2 expression.
- | Invokana (canagliflozin) / J&J, Daiichi Sankyo, Mitsubishi Tanabe
Preclinical, Journal: Canagliflozin combined with aerobic exercise protects against chronic heart failure in rats. (Pubmed Central) - Mar 5, 2024
Additionally, canagliflozin combined with aerobic exercise decreased the phosphorylation of AKT and ERK1/2. Canagliflozin combined with aerobic exercise has a positive effect on the development of CHF via the regulation of retinol metabolism and the AKT/ERK signaling pathway.
- | Strensiq (asfotase alfa) / AstraZeneca
Journal: Pyridoxine challenge reflects pediatric hypophosphatasia severity and thereby examines tissue-nonspecific alkaline phosphatase's role in vitamin B metabolism. (Pubmed Central) - Mar 5, 2024
In contrast, the plasma levels and increments of PA and PL from the PN challenge became less pronounced with HPP severity. We discuss how our findings suggest TNSALP elsewhere than in the skeleton conditioned the PN challenge responses, and explain why they caution against overzealous B supplementation of HPP.
- | Journal: CD19, ALDH18A1, and CACNA1G as Significant Hub Genes in End-Stage Osteoarthritis. (Pubmed Central) - Mar 4, 2024
Additionally, the microRNAs targeting the 4 aforementioned genes were predicted. The present study is the first to provide fresh insights into the potential therapeutic targets of key genes, namely CD19, CACNA1G, and ALDH18A1, differentially expressed in end-stage osteoarthritis and their relevant signaling pathways and interactive microRNAs.
- | pracinostat (SB939) / Helsinn, MEI, Menarini
Journal: ALDH1A3 contributes to tumorigenesis in high-grade serous ovarian cancer by epigenetic modification. (Pubmed Central) - Mar 4, 2024
CHIP assay demonstrated a significant enrichment of H3K27ac at the PITX1 promoter, and ALDH1A3 knockdown reduced the binding between H3K27ac and PITX1. Taken together, our data suggest that ALDH1A3, transcriptional activated by HIF-1?, promotes tumorigenesis and decreases chemosensitivity by increasing H3K27ac of PITX1 promoter in HGSOC.
- | Preclinical, Journal: Golden bile powder prevents drunkenness and alcohol-induced liver injury in mice via the gut microbiota and metabolic modulation. (Pubmed Central) - Mar 3, 2024
Taken together, our data suggest that ALDH1A3, transcriptional activated by HIF-1?, promotes tumorigenesis and decreases chemosensitivity by increasing H3K27ac of PITX1 promoter in HGSOC. GBP is a potent intervention for alcohol-induced pathology and offers hepatoprotective benefits, at least in part, through the modulation of the gut microbiota and related metabolic cascades.