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3 Companies | 4 Products |
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4 Products | |
66 Diseases | |
91 Trials |  |
3673 News |  |
- CALCIUM-DEPENDENT MECHANISMS OF A NOVEL ANTI-FIBROTIC AGENT, M10, IN SCLERODERMA AND NORMAL LUNG FIBROBLASTS (Poster Area) - Feb 13, 2024 - Abstract #SSWC2024SSWC_330;
M10 peptide reduces ECM proteins, inhibits TGF-beta-mediated Ca2+, regulates MMPs and TIMPs and reduces endogenous TGF-beta1. These data suggest that repression of Smad-independent calcium-mediated TGF-beta signaling represents one of the antifibrotic mechanisms of M10.
- | Journal: Disruption of Atrial Rhythmicity by the Air Pollutant 1,2-Naphthoquinone: Role of Beta-Adrenergic and Sensory Receptors. (Pubmed Central) - Jan 27, 2024
Capsazepine, a TRPV1 blocker but not a TRPC5 blocker, reversed 1,2-NQ-induced cardiac changes. In conclusion, neonate mice exposure to AP 1,2-NQ results in an elevated risk of developing cardiac adrenergic dysfunction, potentially leading to atrial arrhythmia at a young age.
- | flecainide / Generic mfg.
Journal: Flecainide Is Associated With a Lower Incidence of Arrhythmic Events in a Large Cohort of Patients With Catecholaminergic Polymorphic Ventricular Tachycardia. (Pubmed Central) - Dec 20, 2023
In conclusion, neonate mice exposure to AP 1,2-NQ results in an elevated risk of developing cardiac adrenergic dysfunction, potentially leading to atrial arrhythmia at a young age. For patients with catecholaminergic polymorphic ventricular tachycardia, adding flecainide to beta-blocker therapy was associated with a lower incidence of AEs in the overall cohort, in symptomatic patients, and particularly in patients with breakthrough AEs while on beta-blocker therapy.
- | Journal: Kinin B1 receptor controls maternal adiponectin levels and influences offspring weight gain. (Pubmed Central) - Dec 7, 2023
Furthermore, fasting insulinemia also increased, which was associated with placental insulin resistance, reduced placental glycogen accumulation, and heavier offspring. Therefore, we propose the combination of chronic hyperinsulinemia and reduced adiponectin secretion in B1KO female mice create a maternal obesogenic environment that results in heavier pups.
- || Bystolic (nebivolol) / Menarini, AbbVie
PK/PD data, Review, Journal: Clinical pharmacokinetics of nebivolol: a systematic review. (Pubmed Central) - Oct 30, 2023
Nebivolol showed higher C, AUC and half-life (t) when co-administered with bupropion, duloxetine, fluvoxamine, paroxetine, lansoprazole, and fluoxetine. This concise review of nebivolol would be advantageous in assessing all PK parameters, which may be crucial for clinicians to avoid drug-drug interactions, prevent adverse drug events and optimize the dosage regimen in diseased patients diagnosed with hypertension and cardiovascular disorders.
- | Preclinical, Journal: Beta1-receptor blockade attenuates atherosclerosis progression following traumatic brain injury in apolipoprotein E deficient mice. (Pubmed Central) - May 30, 2023
In conclusion, accelerated atherosclerosis following TBI is reduced with beta-adrenergic receptor antagonism. Beta blockers may be useful to reduce vascular risk associated with TBI.
- | bisoprolol / Generic mfg.
Journal: Beta-Adrenergic Receptor Blockade Effects on Cardio-Pulmonary Exercise Testing in Healthy Young Adults: A Randomized, Placebo-Controlled Trial. (Pubmed Central) - Dec 21, 2022
The present results suggest that a single dose of bisoprolol does not affect metabolism, respiratory response and exercise capacity. However, beta-adrenergic blockade dose dependently reduces exercise hemodynamic response by lowering BP and the chronotropic response.
- | Preclinical, Journal: Kinin B1 receptor blockade attenuates hepatic fibrosis and portal hypertension in chronic liver diseases in mice. (Pubmed Central) - Dec 16, 2022
However, beta-adrenergic blockade dose dependently reduces exercise hemodynamic response by lowering BP and the chronotropic response. B1Rs merits consideration as a novel therapeutic target for chronic liver fibrosis and PH.
- | Journal: Research advance of the mechanism and treatment of septic cardiomyopathy (Pubmed Central) - Dec 7, 2022
It is one of the major complications that threaten the life of patients with sepsis. The existing research shows that the mechanism of SCM includes myocardial mitochondrial dysfunction, myocardial cell apoptosis, calcium circulation disorder and its treatment including conventional treatment, β1 receptor blocker treatment and traditional Chinese medicine treatment,etc. This paper reviewed the pathogenesis of SCM and its related, in order to provide references for the rational diagnosis and treatment of SCM.
- | Journal: Influence of β Adrenergic Receptor Genotype on Longitudinal Measures of Left Ventricular Ejection Fraction and Responsiveness to ß-Blocker Therapy in Patients With Duchenne Muscular Dystrophy. (Pubmed Central) - Sep 3, 2022
Despite previous literature suggesting a positive influence of ß-blocker use on cardiac function in DMD patients and of an ADRB1 genotypic difference in responsiveness to ß-blocker use, we did not observe this in our cohort. Interestingly, our cohort did not demonstrate a positive influence of ß-blocker use on LVEF measures.
- | galunisertib (LY2157299) / Eli Lilly
Preclinical, Journal: TGF-β1 receptor blockade attenuates unilateral ureteral obstruction-induced renal fibrosis in C57BL/6 mice through attenuating Smad and MAPK pathways. (Pubmed Central) - Aug 18, 2022
These UUO-induced changes were markedly attenuated by oral administration of galunisertib, the TGFβRI small molecule inhibitor. In conclusion, we demonstrated that TGF-β1 receptor blockade can prevent UUO-induced renal fibrosis through indirect modulation of Smad and MAPKs signaling pathways and may be useful as a therapeutic agent in treatment and/or prevention of renal fibrosis.
- bisoprolol / Generic mfg.
Bisoprolol Alters Chorionic Plate Artery Reactivity. () - Apr 6, 2022 - Abstract #SRI2022SRI_610;
Detection of beta-1 adrenergic receptors in the fetoplacental vasculature suggests that bisoprolol may increase CPA vascular resistance by blocking beta-1 receptors and impeding nitric oxide release. Further study is needed to understand whether increased rates of FGR in women exposed to beta blockers associates with mechanisms mediated by beta-1 adrenergic receptors.
- | Journal: Cx43 upregulation in HUVECs under stretch via TGF-β1 and cytoskeletal network. (Pubmed Central) - Mar 31, 2022
Importantly, the upregulation of Cx43 induced by stretch was blocked by the administration of actin and microtubule inhibitors, while NEDD4, a key element in mediating Cx43 protein ubiquitination and degradation, was not changed under the stretch condition. In conclusion, upregulation of Cx43 expression under the 24 h stretch condition is mediated via TGF beta1 receptor signaling pathway, and it also involves the actin and microtubule cytoskeletal network.
- | Journal: Reversal of pulmonary arterial hypertension and neointimal formation by kinin B1 receptor blockade. (Pubmed Central) - Mar 15, 2022
In conclusion, upregulation of Cx43 expression under the 24 h stretch condition is mediated via TGF beta1 receptor signaling pathway, and it also involves the actin and microtubule cytoskeletal network. We conclude that BI113823 reverses preexisting severe experimental pulmonary hypertension via inhibition of macrophage infiltration, cytokine production, as well as down regulation of matrix metalloproteinase proteins.
- | Journal: Metoprolol Protects Against Arginine Vasopressin-Induced Cellular Senescence in H9C2 Cardiomyocytes by Regulating the Sirt1/p53/p21 Axis. (Pubmed Central) - Mar 3, 2022
Finally, Metoprolol was able to downregulate the AVP-induced expression of acetylated p53 and p21. Taken together, our data reveal that Metoprolol protected the cardiomyocytes from AVP-induced senescence.
- || bisoprolol / Generic mfg.
Useful info. Ty. Typo: bisoprolol is beta1 receptor blocker . (Twitter) - Oct 18, 2021
- || Onoact (landiolol) / Ono Pharma
Clinical, Journal: Anaphylactic shock in a patient with severe aortic stenosis treated with adrenaline and landiolol for circulatory management: A case report. (Pubmed Central) - Sep 12, 2021
Landiolol may help control the heart rate of patients with aortic stenosis and anaphylactic shock. The combined use of landiolol and adrenaline may improve patient outcomes; however, their efficacy and risks must be evaluated by studying additional cases.
- | bisoprolol / Generic mfg.
Preclinical, Journal: Contribution of sympathetic activation to antihypertrophic memory after regression of exercise-induced physiological myocardial hypertrophy in mice (Pubmed Central) - May 15, 2021
Seventy-two mice were randomized equally into 6 groups, including sedentary sham-operated group, exercise hypertrophic preconditioning (EHP) + sham operation group, bisoprolol (an adrenergic β1 receptor blocker) + EHP + sham operation group (biso+Exe+Sham group), sedentary group with transverse aortic constriction (TAC) (Sed+TAC group), EHP+ TAC group (Exe+TAC group), and bisoprolol+EHP+TAC group (biso+Exe+TAC group)...No significant difference was found in these parameters between biso + Exe + TAC group and Sed + TAC group. Anti-hypertrophic memory exists even after the regression of exercise-induced PMH, which may be attributed to the activation of sympathetic nervous system during exercise.