- |||||||||| Preclinical, Journal, Metastases: The Therapeutic Efficacy and Mechanism of Action of Gnetin C, a Natural Compound from the Melinjo Plant, in a Preclinical Mouse Model of Advanced Prostate Cancer. (Pubmed Central) - Apr 13, 2024
Further, in addition to decreasing MTA1 levels in prostate epithelial cells, gnetin C significantly reduced mTOR signaling activity in prostate tissues, including the activity of mTOR-target proteins: p70 ribosomal protein S6 kinase (S6K) and eukaryotic translational initiation factor 4E (elF4E)-binding protein 1 (4EBP1). Collectively, these findings established gnetin C as a new natural compound with anticancer properties against MTA1/AKT/mTOR-activated prostate cancer, with potential as monotherapy and as a possible adjunct to clinically approved mTOR pathway inhibitors in the future.
- |||||||||| Preclinical, Journal: Effect of miR-1297 on Kidney Injury in Rats with Diabetic Nephropathy through the PTEN/PI3K/AKT Pathway. (Pubmed Central) - Apr 11, 2024
Collectively, these findings established gnetin C as a new natural compound with anticancer properties against MTA1/AKT/mTOR-activated prostate cancer, with potential as monotherapy and as a possible adjunct to clinically approved mTOR pathway inhibitors in the future. AntagomiR-1297 can mitigate renal fibrosis, renal inflammation, apoptosis, and oxidative stress levels through the PTEN/PI3K/AKT pathway.
- |||||||||| Journal: Bibliometric analysis of PTEN in neurodevelopment and neurodegeneration. (Pubmed Central) - Apr 8, 2024
These findings can assist new researchers in developing their research interests and gaining basic information. Moreover, our findings also may provide precise clinical guidelines and strategies for treating nervous system injuries and diseases caused by PTEN dysfunction.
- |||||||||| bleomycin / Generic mfg.
Journal: MicroRNA-21a-5p inhibition alleviates systemic sclerosis by targeting STAT3 signaling. (Pubmed Central) - Apr 6, 2024
ERG rearrangements and PTEN deletions detected on biopsy samples are associated with poorer oncologic outcomes in prostate cancer patients treated with SBRT and merit further study in a dedicated prospective trial. MiRNA-21a-5p promotes fibrosis in an in vivo murine SSc model, suggesting that its inhibition may be a therapeutic strategy for improving fibrosis in SSc.
- |||||||||| Journal: FGF4 protects the liver from immune-mediated injury by activating CaMKK?-PINK1 signal pathway to inhibit hepatocellular apoptosis. (Pubmed Central) - Apr 4, 2024
The beneficial effects of FGF4 were mediated by hepatocellular FGF receptor 4, which activated the Ca2+/calmodulin-dependent protein kinasekinase 2 (CaMKK?) and its downstream phosphatase and tensin homologue-induced putative kinase 1 (PINK1)-dependent B-cell lymphoma 2-like protein 1-isoform L (Bcl-XL) signalling axis in the mitochondria. Hence, FGF4 serves as an early response factor and plays a protective role against ILI, suggesting a therapeutic potential of FGF4 and its analogue for treating clinical immune disorder-related liver injuries.
- |||||||||| Journal: Knowledge Mapping of Cowden Syndrome: a Bibliometric Analysis. (Pubmed Central) - Apr 1, 2024
This study was the first comprehensive bibliometric overview of the current state and development of Cowden disease. The mutation of PTEN and associated cancers, especially breast, thyroid and endometrial cancer, could be the focus of future research in this field.
- |||||||||| tamoxifen / Generic mfg.
Journal: Phosphatase and Tensin Homolog Inhibition in Proteolipid Protein 1-Expressing Cells Stimulates Neurogenesis and Gliogenesis in the Postnatal Enteric Nervous System. (Pubmed Central) - Apr 1, 2024
To investigate this, we generated two tamoxifen-inducible Cre recombinase murine models in which Pten was conditionally ablated, (1) in glia (Plp1-expressing cells) and (2) in neurons (Calb2-expressing cells)...Pten inhibition in Calb2-expressing cells did not induce enteric neuro- or gliogenesis, and no alterations were detected in CMMC or whole gut transit times when compared to the control at baseline or post-DSS (early and late). Our results merit further research into Pten modulation where increased glia and/or slower intestinal transit times are desired (e.g., short-bowel syndrome and rapid-transit disorders).
- |||||||||| Preclinical, Journal: Pten knockout in mouse preosteoblasts leads to changes in bone turnover and strength. (Pubmed Central) - Mar 20, 2024
On the cellular level, both proliferation and osteogenic differentiation capacity of Pten cKO BMSCs were significantly increased compared to controls. Our findings suggest that Pten knockout in osteoprogenitor cells increases bone stability and elasticity by increasing trabecular bone mass and leads to increased proliferation and osteogenic differentiation of BMSCs.
- |||||||||| Journal: Clinicopathological Evaluation of Papillary Thyroid Microcarcinoma. (Pubmed Central) - Mar 19, 2024
There might be a possibility that the natural progression of PMC seems to be controlled by the facilitation of PTEN. However, a tumor in the lateral peripheral region of the thyroid parenchyma might be associated with capsule invasion followed by lymphatic spread.
- |||||||||| prinaberel (ERB-041) / Pfizer
Journal, IO biomarker, Tumor cell: Synergistic Anti-Cancer Effects of ERB-041 and Genistein through Estrogen Receptor Suppression-Mediated PI3K/AKT Pathway Downregulation in Canine Mammary Gland Tumor Cells. (Pubmed Central) - Mar 17, 2024
We also found a synergistic decrease in the expression of ER?, and the expression of proteins involved in the PI3K/AKT pathway, including p-PI3K, phosphatase and tensin homolog (PTEN), AKT, and mechanistic target of rapamycin (mTOR). In conclusion, ERB-041 and genistein exhibited a synergistic anticancer effect on CMTs, suggesting that cotreatment with ERB-041 and genistein is a promising treatment for CMTs.
- |||||||||| voxtalisib (SAR245409) / Sanofi
A genome wide CRISPR-Cas9 screen identifies mediators of resistance to dual PI3K/mTOR inhibition in glioblastoma multiforme (Section 23) - Mar 5, 2024 - Abstract #AACR2024AACR_8085;
The current standard of care, consisting of surgery, radiation, and temozolomide (TMZ), has remained unchanged for over the past 15 years despite its limited efficacy and the serious therapy-related adverse events associated to this regimen...To elucidate mechanisms of resistance to PI3K inhibition in GBM, we used a genome-wide functional CRISPR-Cas9 knockout screen to identify genes that mediate resistance to the dual PI3K/mTOR inhibitor XL765 in PTEN-null SF295 GBM cells...Using orthogonal approaches, we will functionally validate our candidate hits through mechanistic studies, with patient-derived models, and with in vivo orthotopic xenografts. Our findings will elucidate novel mechanisms of resistance to PI3K/mTOR inhibition in GBM and will streamline rational drug combinations aimed to overcome resistance, thus eventually maximizing therapeutic responses to PI3K inhibitors in GBM.
- |||||||||| The Prognostic Event for MAFLD: CVD or Extrahepatic Cancers? () - Mar 5, 2024 - Abstract #APASL2024APASL_2950;
Accumulation of fat at ectopic locations and adipose tissue dysfunction have also been implicated in the development of MAFLD. Secretion of various hepatokines such as retinol-binding protein-4, fetuin-A, fibroblast-growth factor 21 and inflammatory cytokines, tumor-necrosisfactor alpha, C-reactive protein and interleukin-6 cause hepatic gluconeogenesis, glycogen synthesis and insulin resistance which together drives complications in these patients.
- |||||||||| everolimus / Generic mfg.
Journal: FOXO3a Induces Myocardial Fibrosis by Upregulating Mitophagy. (Pubmed Central) - Mar 4, 2024
Secretion of various hepatokines such as retinol-binding protein-4, fetuin-A, fibroblast-growth factor 21 and inflammatory cytokines, tumor-necrosisfactor alpha, C-reactive protein and interleukin-6 cause hepatic gluconeogenesis, glycogen synthesis and insulin resistance which together drives complications in these patients. FOXO3a promotes the progress of myocardial fibrosis by triggering mitophagy in cardiac fibroblasts.
- |||||||||| Journal: PTEN Mediates the Silencing of Unintegrated HIV-1 DNA. (Pubmed Central) - Feb 28, 2024
Finally, the knockout of PTEN increases the levels of active epigenetic marks (H3ac and H3K4me3) and the recruitment of PolII on unintegrated HIV-1 DNA chromatin. Our experiments reveal that PTEN targets transcription factors (NF-?B, Sp1, and AP-1) by negatively regulating the PI3K-Akt pathway to promote the silencing of unintegrated HIV-1 DNA.
- |||||||||| Biomarker, Review, Journal: Tissue-Based Diagnostic Biomarkers of Aggressive Variant Prostate Cancer: A Narrative Review. (Pubmed Central) - Feb 24, 2024
The understanding of the biologic heterogeneity of castration-resistant PC (CRPC) and the need to identify the subset of patients that would potentially benefit from specific therapies necessitate the development of prognostic and predictive biomarkers. This review aims to discuss the possible pathophysiologic mechanisms of AVPC development and the potential use of emerging tissue-based biomarkers in clinical practice.
- |||||||||| MAGI2 Is Involved in the Pathogenesis of Pulmonary Fibrosis (San Diego Convention Center, Area E (Hall A-B2, Ground Level)) - Feb 20, 2024 - Abstract #ATS2024ATS_2057;
This competition attenuates USP8 mRNA stability and protein expression, leading to PTEN protein degradation, consequently, this process drives urothelial cell malignant transformation and fosters BMIBC growth and primary BMIBC formation. Collectively, current observations support the hypothesis that MAGI2 is a negative regulator of fibroblast to myofibroblast differentiation via PTEN stability.
- |||||||||| Journal: Multiple bronchial carcinoids associated with Cowden syndrome. (Pubmed Central) - Feb 14, 2024
Our patient is the first published case of Cowden syndrome, associated with multifocal pulmonary carcinoids. Besides multiple endocrine neoplasia type 1, we propose Cowden syndrome as another hereditary condition predisposing to multiple pulmonary tumorlets and carcinoid tumours.
- |||||||||| Review, Journal: Angiogenic activity of mitochondria; beyond the sole bioenergetic organelle. (Pubmed Central) - Feb 14, 2024
Despite the existence of a close relationship between mitochondrial donation and angiogenic response in different cell types, the precise molecular mechanisms associated with this phenomenon remain unclear. Here, we aimed to highlight the possible role of mitochondria concerning angiogenesis, especially the role of mitochondrial transport and the possible relation of this transfer with autophagy, the housekeeping phenomenon of cells, and angiogenesis.
- |||||||||| Journal, PARP Biomarker: Use of antioxidant nanoliposomes for co-delivery of PTEN plasmids and plumbagin to induce apoptosis in hepatic cancer cells. (Pubmed Central) - Feb 6, 2024
Other cellular events such as Caspase-7 overexpression and PI3K, AKT, PARP, and mTOR inhibition led to the apoptosis in hepatic cancer cells. The mRNA expression profile of PTEN, PI3K, AKT3, caspase-7, PARP and mTOR proteins, primarily controlling the cancer cell proliferation and apoptosis, suggest that exogenous supply of PTEN could regulate the expression of oncogenic proteins and thus cancer progression.
- |||||||||| Review, Journal: Cadmium Exposure Induces Apoptosis and Necrosis of Thyroid Cells via the Regulation of miR-494-3p/PTEN Axis. (Pubmed Central) - Jan 26, 2024
This study demonstrates the role of microRNAs in regulating Cd toxicity in pig thyroid tissue and provides evidence of Cd's negative effects. It further provides an assessment of the toxicological impact of Cd as an environmental endocrine disruptor (ED) that threatens public health and safety, which forms a basis for the development of Cd poisoning treatment therapies.
- |||||||||| Journal: Integrative Analysis of circRNA Networks in Postoperative Cognitive Dysfunction. (Pubmed Central) - Jan 23, 2024
The ensuing competing endogenous RNA (ceRNA) network, featuring pivotal players like Homo sapiens(hsa)_circ_0003424 and hsa-miR-193b-5p, provided a comprehensive understanding of the molecular players at play in POCD. Additionally, the Protein-Protein Interaction (PPI) network spotlighted 10 core Hub genes, including phosphatase and tensin homolog (PTEN) and signal transducer and activator of transcription 3(STAT3), shedding light on potential therapeutic targets.
- |||||||||| Journal, PD(L)-1 Biomarker, IO biomarker: Combination of AAV-delivered tumor suppressor PTEN with anti-PD-1 loaded depot gel for enhanced antitumor immunity. (Pubmed Central) - Jan 23, 2024
In order to effectively inhibit the recurrence of melanoma, we further applied a triple therapy based on AAV6-PTEN, PPSG and CpG, and showed that this triple therapy strategy enhanced the synergistic antitumor immune effect and also induced robust immune memory, which completely rejected tumor recurrence. We anticipate that this triple therapy could be used as a new tumor combination therapy with stronger immune activation capacity and tumor inhibition efficacy.
|
