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- | Preclinical, Journal: TGFB1 modulates in vitro secretory activity and viability of equine luteal cells. (Pubmed Central) - Oct 27, 2019
Finally, TGF decreased cell viability (p < 0.05) and promoted caspase 3 activity (p = 0.08) and the expression of pro-apoptotic FASL and BAX (p < 0.05). Our results suggest that TGF supports functional regression and structural luteolysis, and also confirm the importance of ALK5, ALK4 and ALK7 activation during PGF2a mediated luteolysis in mares.
- | Journal: Amniotic membrane stimulates cell migration by modulating Transforming Growth Factor-β signaling. (Pubmed Central) - Oct 20, 2019
The involvement of Smad signaling onto AM effects on HaCaT keratinocytes was further corroborated by overexpression of either Smad2 or Smad3 and the use of Smad-phosphorylation specific inhibitors, revealing a differential influence on AM induced migration for each Smad. Thus, AM TGF-ß-Smad-signaling abating is essential for optimal cell migration and wound closure.
- | Journal: A Pan-Cancer Analysis Reveals High-Frequency Genetic Alterations in Mediators of Signaling by the TGF-β Superfamily. (Pubmed Central) - Oct 18, 2019
Correlation analyses showed the contributions of mutation, amplification, deletion, DNA methylation, and miRNA expression to transcriptional activity of TGF-β signaling in each cancer type. This study provides a broad molecular perspective relevant for future functional and therapeutic studies of the diverse cancer pathways mediated by the TGF-β superfamily.
- | Journal: The prion protein is embedded in a molecular environment that modulates transforming growth factor β and integrin signaling. (Pubmed Central) - Oct 11, 2019
Strikingly, although several proteins exhibited profound co-enrichment with PrP in a given model, except for the neural cell adhesion molecule 1, no protein was highly enriched in all PrP-specific interactomes. However, Gene Ontology analyses revealed a shared association of the majority of PrP candidate interactors with cellular events at the intersection of transforming growth factor β and integrin signaling.
- | Journal: Butyrate produced by gut commensal bacteria activates TGF-beta1 expression through the transcription factor SP1 in human intestinal epithelial cells. (Pubmed Central) - Oct 11, 2019
Finally, our results showed that SP1 was the main transcription factor mediating the HDAC inhibitor effect of butyrate on TGFB1 expression. This is, to our knowledge, the first characterisation of the mechanisms underlying TGFB1 regulation in IEC by commensal bacteria derived butyrate.
- Polycomb repressive complex 2 represses pro-fibrotic activity in the decidual stroma by modulating the transforming growth factor β pathway. () - Oct 4, 2019 - Abstract #CRICIMTEATIAACR2019CRI-CIMT-EATI-AACR_158;
Transforming growth factor β (TGF-β) signaling was central to the observed defects, and in-vivo blockade of TGF-β signaling partially rescued the dysregulation caused by PRC2 deficiency. Our investigation stands at the novel crossroads of immunity, fibrotic responses, and epigenetics, and the mechanisms we uncover will give us greater insight into stromal control of its local environment.
- | Preclinical, Journal: Proteomics Reveals Rictor as a Non-Canonical TGFB Signaling Target During Aneurysm Progression in Marfan Mice. (Pubmed Central) - Sep 28, 2019
Our investigation stands at the novel crossroads of immunity, fibrotic responses, and epigenetics, and the mechanisms we uncover will give us greater insight into stromal control of its local environment. These results reveal that Rictor is a novel, context-dependent, non-canonical TGFβ-signaling effector with potential pathogenic implications in aortic aneurysm.
- | Journal: The Secretin/Secretin Receptor Axis Modulates Ductular Reaction and Liver Fibrosis through Changes in Transforming Growth Factor (TGF)-β1-Mediated Biliary Senescence. (Pubmed Central) - Aug 15, 2019
Secretin directly stimulated the senescence of cholangiocytes and regulated, by a paracrine mechanism, the senescence of hepatic stellate cells and liver fibrosis via modulation of transforming growth factor-β1 biliary secretion. Targeting senescent cholangiocytes may represent a novel therapeutic approach for ameliorating hepatic fibrosis during cholestatic liver injury.
- | Journal: CSIG is essential for PPM1A myristoylation to modulate the TGFβ signaling. (Pubmed Central) - Jun 19, 2019
Through promoting the myristoylation of PPM1A, CSIG enhanced the phosphatase activity of PPM1A and further inhibited the TGFβ signaling. This work not only extends the biological significance of CSIG but also provides new ideas and reference for the regulatory mechanism study of myristoylation.
- | Journal: Fibroblast Growth Factor-2 and Transforming Growth Factor-beta1 Oppositely Regulate miR-221 that Targets Thrombospondin-1 in Bovine Luteal Endothelial Cells. (Pubmed Central) - Jun 7, 2019
These data support the contention that FGF2 and TGFB1 modulate THBS1 via miR-221. These in vitro data propose that dynamic regulation of miR-221 throughout the cycle, affecting THBS1 and SERPINE1, can modulate vascular function in the CL.
- | Journal: Calycosin Inhibits Intestinal Fibrosis on CCD-18Co Cells via Modulating Transforming Growth Factor-β/Smad Signaling Pathway. (Pubmed Central) - Jun 6, 2019
Our study highlighted that CA-inhibited TGF-β/Smad pathway through inhibiting the expression of p-Smad2, p-Smad3, Smad4, and TGF-β1 and raised the Smad7 expression. Therefore, CA might inhibit intestinal fibrosis by inhibiting the TGF-β/Smad pathway.
- |||| Preclinical: This study indicates that the three CsA formulations effectively modulated TLR4, TGFβ1, IL1, and IL6 pathways to reduce corneal epithelium lesions in a mouse model of severe dry eye. @Dryeyemaster @DarrellWhite https://t.co/RK3lW6Sg3W (Twitter) - May 3, 2019
- | Journal: Inhibitory role of transforming growth factor β2 in experimental autoimmune anterior uveitis. (Pubmed Central) - May 2, 2019
TGF-β2 plays a critical role in regulation of intraocular inflammation in EAAU. Findings reported in this study improve our understanding of immunopathology of IAU and suggest that recombinant TGF-β2 may be a promising therapeutic agent for human IAU.
- | temozolomide / generics
Review, Journal, Tumor Mutational Burden, IO Biomarker: Irradiation to Improve the Response to Immunotherapeutic Agents in Glioblastomas. (Pubmed Central) - Apr 25, 2019
Glioblastoma (GBM) remains an incurable disease despite extensive treatment with surgical resection, irradiation, and temozolomide...Various immunotherapy agents, including immune checkpoint modulators, transforming growth factor beta receptor inhibitors, and indoleamine-2,3-dioxygenase inhibitors, have been evaluated with irradiation in preclinical GBM models, with promising results, and are being further tested in clinical trials. This review aims to present the basic rationale behind this emerging complementary therapeutic approach in GBM, appraise the current preclinical and clinical data, and discuss the future challenges in improving the antitumor immune response.
- | Journal: Early Enhanced Leucine-Rich α-2-Glycoprotein-1 Expression in Glomerular Endothelial Cells of Type 2 Diabetic Nephropathy Model Mice. (Pubmed Central) - Mar 21, 2019
At this late stage, glomerular VEGF and fibrosis-related-gene expression was also significantly increased compared with nondiabetic db/m mice. These results suggest that LRG1 plays a pivotal role in the initial development of diabetic nephropathy by promoting abnormal angiogenesis, thereby suggesting that LRG1 is a potential preemptive therapeutic target of diabetic nephropathy.