 |
8 Companies | 6 Products |
|
|
6 Products | |
212 Diseases | |
72 Trials |  |
2067 News |  |
| «12345678910111213» |
- | Journal: TGFβ2-induced formation of lipid droplets supports acidosis-driven EMT and the metastatic spreading of cancer cells. (Pubmed Central) - Apr 26, 2020
We show that upon TGF-β2 stimulation, PKC-zeta-mediated translocation of CD36 facilitates the uptake of fatty acids that are either stored as triglycerides in LD through DGAT1 or oxidized to generate ATP to fulfill immediate cellular needs. We also address how, by preventing fatty acid mobilization from LD, distant metastatic spreading may be inhibited.
- | Journal: Vitamin D produces a perilipin 2-dependent increase in mitochondrial function in C2C12 myotubes. (Pubmed Central) - Apr 22, 2020
PLIN2 was required for a calcitriol-induced increase in oxygen consumption driven by mitochondrial complex II. We conclude that calcitriol increases mitochondrial function in myotubes and that this increase is at least in part mediated by PLIN2.
- | Journal, IO Biomarker: Cardamonin suppresses lipogenesis by activating protein kinase A-mediated browning of 3T3-L1 cells. (Pubmed Central) - Apr 22, 2020
We conclude that calcitriol increases mitochondrial function in myotubes and that this increase is at least in part mediated by PLIN2. Our findings demonstrate novel effects of cardamonin to stimulate adipocyte browning, suppress lipogenesis, and promote lipolysis, implying it may have potential as an anti-obesity agent.
- | Journal: Evaporative cooling provides a major metabolic energy sink. (Pubmed Central) - Apr 14, 2020
In particular, we turn attention to widely different rates of evaporative cooling as the result of trans-epidermal water loss; higher rates of heat loss by evaporative cooling leads to increased demand for thermogenesis. We speculate that this physiology could be harnessed to create an energy sink to assist with strategies aimed at treating metabolic diseases.
- || Clinical, Journal: Phenotype and Genotype of a Cohort of Chinese Children with Early-Onset Protein-Losing Enteropathy. (Pubmed Central) - Apr 12, 2020
We speculate that this physiology could be harnessed to create an energy sink to assist with strategies aimed at treating metabolic diseases. Monogenic diseases may be observed in children with early-onset protein-losing enteropathy, and genetic evaluation with next-generation sequencing should be considered.
- || BOS-356 / Boston Pharma, GSK
Clinical, Journal: A Population Analysis of the DGAT1 Inhibitor GSK3008356 and its Effect on Endogenous and Meal-Induced Triglyceride Turnover in Healthy Subjects. (Pubmed Central) - Apr 10, 2020
The current analysis presents a PKPD modeling strategy of time-varying TG data coming from both endogenous and exogenous sources. In general, the presented model could be utilized in the model-based drug development of drugs that influence TG levels in blood.
- | Journal: Rewiring Neuronal Glycerolipid Metabolism Determines the Extent of Axon Regeneration. (Pubmed Central) - Mar 31, 2020
In addition, peripheral neurons adopted this mechanism for their spontaneous axon regeneration. Our study reveals a critical role of lipin1 and DGATs as intrinsic regulators of glycerolipid metabolism in neurons and indicates that directing neuronal lipid synthesis away from TG synthesis and toward PL synthesis may promote axon regeneration.
- | Journal: Exploring novel single nucleotide polymorphisms and haplotypes of the diacylglycerol O-acyltransferase 1 (DGAT1) gene and their effects on protein structure in Iranian buffalo. (Pubmed Central) - Mar 20, 2020
Our study reveals a critical role of lipin1 and DGATs as intrinsic regulators of glycerolipid metabolism in neurons and indicates that directing neuronal lipid synthesis away from TG synthesis and toward PL synthesis may promote axon regeneration. Our results suggest that genetic diversity exists and could be useful in examining the association between the DGAT1 gene and milk production traits in buffalo.
- | Journal: Effect of DNA markers on the fertility traits of Japanese Black cattle for improving beef quantity and quality. (Pubmed Central) - Mar 14, 2020
However, previous studies reported that the effects of DNA markers could differ among populations. Therefore, it is necessary to confirm the effect of the marker in each population before it is used for improvement.
- | Journal: Genome-wide analysis and functional characterization of Acyl-CoA:diacylglycerol acyltransferase from soybean identify GmDGAT1A and 1B roles in oil synthesis in Arabidopsis seeds. (Pubmed Central) - Mar 13, 2020
Our results reveal the functions of soybean DGATs in seed oil synthesis using transgenic Arabidopsis. The implications for the biotechnological modification of the oil contents in soybeans by altering DGAT expression are discussed.
- DGAT1 MUTATION OF LIPID TRAFFICKING ASSOCIATED WITH A RARE CASE OF CONGENITAL DIARRHEA () - Mar 8, 2020 - Abstract #CDDW2020CDDW_110;
Management strategies currently focus on growth with dietary lipid restriction, while substituting fat-soluble vitamins and essential fatty acids. Funding Agencies CAG
- | Journal: A novel mutation in the promoter region of RPL8 regulates milk fat traits in dairy cattle by binding transcription factor Pax6. (Pubmed Central) - Mar 2, 2020
Altogether, our study indicated that g.-931G > T at RPL8 promoter altered its expression by affecting the interplay between Pax6 and RPL8, which may account for the association with milk fat traits. Findings herein first elucidated the biological function of RPL8 gene in milk fat and the identified SNP g.-931G > T may be considered as genetic makers for breeding in dairy cattle.
- | Journal: Benzimidazole-based DGAT1 inhibitors with a [3.1.0] bicyclohexane carboxylic acid moiety. (Pubmed Central) - Feb 26, 2020
Our results show that single isomer 3A maintains in vitro and in vivo inhibition against DGAT1. In contrast to previous lead compounds, 3A does not undergo isomerization during in vitro hepatocyte incubation study or in vivo mouse study.
- | Journal: Maternal heat stress regulates the early fat deposition partly through modification of mA RNA methylation in neonatal piglets. (Pubmed Central) - Feb 25, 2020
In conclusion, our findings showed that heat stress increased expression of genes involved in lipogenesis, which provided scientific evidence to the observation of increased fatness in pigs under heat stress. We also demonstrated a possible mechanism that mA RNA modification may be associated with these changes in lipid metabolism upon heat stress.
- | Journal: A new bioactive coumestan from the seeds of Psoralea corylifolia. (Pubmed Central) - Feb 24, 2020
Among them, compounds 1-2, 5-6 showed potential inhibitory activity on DGAT1 with IC values ranging from 52.3 ± 1.3 to 81.0 ± 1.0 μM. Compounds 1-3, 6 displayed the significant inhibitory activity on α-glucosidase with IC values ranging from 31.2 to 89.1 μM.
- | Journal: Two new isoflavones from the seeds of Psoralea corylifolia with diacylglycerol acyltransferase inhibitory activity. (Pubmed Central) - Feb 24, 2020
All the isolates were evaluated for in vitro inhibitory activity against diacylglycerol acyltransferase (DGAT). And compounds 1-7 displayed significant inhibitory activity on DGAT1 with IC values ranging from 51.2 ± 1.1 to 116.4 ± 1.3 μM.
- | Journal: Gene polymorphisms influencing on yield, composition and technological properties of milk from Czech Simmental and Holstein cows. (Pubmed Central) - Feb 15, 2020
The findings revealed the potential of some polymorphic loci for use in dairy cattle breeding and for the management of milk quality. In field research, the pivotal role of farms in milk yield, composition and technological properties was confirmed.
- Cholestasis reduced hepatic lipid content in HBsAg transgenic mice () - Feb 15, 2020 - Abstract #PLCECNT2020PLC_ECNT_56;
The hepatic lipid metabolism in HBs mice is altered by con- comitant cholestasis as induced by Abcb4 KO. Whether the suppression of de novo lipogenesis is of advantage has to be carved out.
- | Journal: Hepatic VLDL secretion: DGAT1 determines particle size but not particle number which is supported by DGAT2 activity in the absence of DGAT1. (Pubmed Central) - Feb 14, 2020
Therefore, our findings show that DGAT1 is essential for the complete lipidation and maturation of VLDL particles within the lumen of the ER, consistent with its dual topology within the ER membrane. In the mouse, DGAT2 can support apoB secretion (particle number) even when TAG availability for full VLDL lipidation is restricted in the absence of DGAT1.
- | Clinical, Journal: Combining multi-population datasets for joint genome-wide association and meta-analyses: The case of bovine milk fat composition traits. (Pubmed Central) - Feb 14, 2020
Our results show that combining multi-population data set can be a powerful tool to enhance detection power in GWAS for seldom-recorded traits. Detection of a higher number of regions using the meta-analysis, compared with any of the population-specific analyses also emphasizes the utility of these methods in the absence of raw multi-population data sets to undertake joint GWAS.
- | Journal: Interaction of DGAT1 and PDAT1 to enhance TAG assembly in Arabidopsis. (Pubmed Central) - Feb 7, 2020
Here, we further found that DGAT1 and PDAT1 physically associate, possibly to enhance the efficiency of TAG production. Overall, our findings suggest that TAG biosynthesis is intricately regulated at multiple levels, and these molecular strategies can potentially be used for metabolic engineering in plants.
- | Journal: Genome-wide association analysis for β-hydroxybutyrate concentration in Milk in Holstein dairy cattle. (Pubmed Central) - Feb 7, 2020
Overall, our findings suggest that TAG biosynthesis is intricately regulated at multiple levels, and these molecular strategies can potentially be used for metabolic engineering in plants. The results of this study confirmed several SNPs and genes identified in previous studies as associated with ketosis susceptibility and immune response, and also found a novel region that can be used for further analysis to identify causal variations and key regulatory genes that affect clinical/ subclinical ketosis.
- | Preclinical, Journal: Wheat Flour, Enriched with γ-Oryzanol, Phytosterol, and Ferulic Acid, Alleviates Lipid and Glucose Metabolism in High-Fat-Fructose-Fed Rats. (Pubmed Central) - Jan 30, 2020
Western blot analysis of proteins from liver samples reveals that these enriched flours alleviated hepatic lipid accumulation and insulin resistance through their elevation in the phosphorylation of AMPK and Akt. (4) Our study indicates that these enriched flours can serve as a health-promoting functional food to regulate obesity-related lipid/glucose metabolic dysfunction in rats.
- | Review, Journal: Obesity medications in development. (Pubmed Central) - Jan 29, 2020
Combining medications targeting more than one of the redundant mechanisms driving obesity increases efficacy. However, targeting peripheral mechanisms to overcome the trickle-down effects of centrally acting drugs may be the key to success in treating obesity.
- | Journal: Analysis of Candidate Genes for Growth and Milk Performance Traits in the Egyptian Barki Sheep. (Pubmed Central) - Jan 26, 2020
In ewes, significant effects on milk yield and composition have been estimated for LEP (rs420693815), STAT5A (rs161082816), PRL (rs422713690), and GHRHR (rs414991449). The results indicated that these genes might be considered as interesting candidates for further investigations to improve growth and milk performance in Barki sheep.
- LUMINAL RARE DISEASES IMPACTING ABSORPTION : CFTR, NHE3, DGAT-1 (Room: E353a - McCormick Place) - Jan 23, 2020 - Abstract #DDW2020DDW_741;
- | Journal: Synthesis and biological evaluation of novel thienopyrimidine derivatives as diacylglycerol acyltransferase 1 (DGAT-1) inhibitors. (Pubmed Central) - Jan 15, 2020
Oral administration of 17a led to a significant reduction in plasma triacylglycerol level during an oral lipid tolerance test (OLTT) in murine and canine models. Taken together, 17a is a high-quality candidate that deserves further investigation.
- | Journal: Extracellular Fatty Acids are the Major Contributor to Lipid Synthesis in Prostate Cancer. (Pubmed Central) - Jan 11, 2020
These outcomes highlight for the first-time heterogeneity of lipid metabolism in prostate cancer cells and the potential influence that obesity-associated dyslipidemia or host circulating has on prostate cancer progression. Implications: Extracellular-derived FAs are primary building blocks for complex lipids and heterogeneity in FA metabolism exists in prostate cancer that can influence tumor cell behavior.
- | Journal: Western Diet-Induced Metabolic Alterations Affect Circulating Markers of Liver Function before the Development of Steatosis. (Pubmed Central) - Jan 11, 2020
Significant changes in hepatic lipid and drug metabolism are early induced by the Western diet, prior to steatosis development. Such changes are associated with a peculiar alteration in circulating bile acids, which could represent an early marker of non-alcoholic fatty liver disease (NAFLD) development.
- | Journal: New polyacetylenes glycoside from Eclipta prostrate with DGAT inhibitory activity. (Pubmed Central) - Jan 1, 2020
All the isolates were evaluated inhibitory activity on DGAT in an in vitro assay. Compounds 1-8 were found to exhibit inhibitory activity of DGAT1 with IC values ranging from 74.4 ± 1.3 to 101.1 ± 1.1 μM.
- | Journal: Anti-diabetic compounds from the seeds of Psoralea corylifolia. (Pubmed Central) - Dec 25, 2019
Compounds 1, 2 and 3 showed potential inhibitory activities on DGAT1 with IC values of 35.2 ± 1.3, 51.3 ± 1.1 and 43.4 ± 0.7 μM, respectively. Compounds 6 and 8 displayed the significant inhibitory activities on α-glucosidase with IC value of 28.0 and 23.0 μM, respectively.
- | sirolimus / Generic mfg.
Journal: mTORC2 Regulates Lipogenic Gene Expression through PPARγ to Control Lipid Synthesis in Bovine Mammary Epithelial Cells. (Pubmed Central) - Dec 20, 2019
The mechanistic target of rapamycin complex 2 (mTORC2) primarily functions as an effector of insulin/PI3K signaling to regulate cell proliferation and is associated with cell metabolism...In the present study, mTORC2 was inactivated by the ATP-competitive mTOR inhibitor AZD8055 or shRNA targeting RICTOR in primary bovine mammary epithelial cells (pBMECs)...Overall, mTORC2 plays a critical role in regulating lipogenic gene expression, lipid synthesis, and secretion in pBMECs, and this process probably is through PPARγ. This finding provides a model by which lipogenesis is regulated in pBMECs.
- | Journal: Crambe hispanica Subsp. abyssinica Diacylglycerol Acyltransferase Specificities Towards Diacylglycerols and Acyl-CoA Reveal Combinatorial Effects That Greatly Affect Enzymatic Activity and Specificity. (Pubmed Central) - Dec 8, 2019
This finding implies that the use of artificial acyl acceptors (e.g. di-6:0-DAG) may not always reflect the actual acyl-CoA specificities of DGATs in planta. The relevance of the here reported pronounced specificities for specific DAG species exerted by DGAT enzymes is discussed in the context of the findings of DAG pools of distinct catalytic origin in triacylglycerol biosynthesis in the seed oil.
- | Journal: Comprehensive assessment of candidate genes associated with fattening performance in Holstein-Friesian bulls. (Pubmed Central) - Dec 8, 2019
The results of this study confirm some previously reported associations. Moreover, novel associations have been identified, which may be incorporated into breeding programs to improve fattening performance.
- | Journal: Mangifera indica L. Leaf Extract Induces Adiponectin and Regulates Adipogenesis. (Pubmed Central) - Dec 6, 2019
Consistently with these results, MLE resulted in a significant decrease of the expression of genes involved in lipid metabolism (FAS, PPARG, DGAT1, DGAT2, and SCD-1). In conclusion, our results suggest that MLE may represent a possible pharmacological tool for obese or metabolic syndrome patients.
- | Journal: A Comprehensive Analysis of Runs of Homozygosity of Eleven Cattle Breeds Representing Different Production Types. (Pubmed Central) - Dec 1, 2019
In regions of the genome with a high frequency of ROH occurrence, which may reflect the impact of directional selection, a number of genes were observed that can be potentially related to the production traits which are under selection pressure for specific production types. The most important detected genes were GHR, MSTN, DGAT1, FABP4, and TRH, with a known influence on the milk and meat traits of the studied cattle breeds.
- || Clinical, Journal: Genetic variants in DGAT1 cause diverse clinical presentations of malnutrition through a specific molecular mechanism. (Pubmed Central) - Dec 1, 2019
This report adds on to the database for existing mutations known within DGAT1, a gene recently implicated with CDD, and also expands its clinical spectrum. Identification of these DGAT1 mutations by WES has allowed for changes in the patients' nutritional rehabilitation, reversed growth failure and enabled them to be weaned off of total parenteral nutrition (TPN).
- | Journal: Effect of estradiol on hepatopancreatic lipid metabolism in the swimming crab, Portunus trituberculatus. (Pubmed Central) - Nov 29, 2019
Histological observations indicated the size of B cell became larger under estradiol treatment. The results indicated that estradiol promoted lipid catabolism in the hepatopancreas of P. trituberculatus.
- | Journal: Triglycerides Promote Lipid Homeostasis during Hypoxic Stress by Balancing Fatty Acid Saturation. (Pubmed Central) - Nov 28, 2019
Disrupting this process derails lipid homeostasis, causing overproduction of toxic saturated ceramides and acyl-carnitines as well as activation of the NF-κB transcription factor. Our work demonstrates that triglycerides promote homeostasis by "buffering" specific fatty acids.
- | Journal: Genome-wide association for milk production traits and somatic cell score in different lactation stages of Ayrshire, Holstein, and Jersey dairy cattle. (Pubmed Central) - Nov 27, 2019
Therefore, our results suggest evidence of differential sets of candidate genes underlying the phenotypic expression of the analyzed traits across breeds, parities, and lactation stages. Further functional studies are needed to validate our findings in independent populations.
- | Journal: Genome-Wide Association Study for Milk Fatty Acids in Holstein Cattle Accounting for the DGAT1 Gene Effect. (Pubmed Central) - Nov 24, 2019
When fitting the DGAT1 gene in the model, only the MGST1 and PLBD1 genes were identified. Thus, this study suggests that the DGAT1 gene accounts for most of the variability in milk fatty acid composition and the PLBD1 and MGST1 genes are important additional candidate genes in Holstein cattle.
- | Journal: In silico design of diacylglycerol acyltransferase-1 (DGAT1) inhibitors based on SMILES descriptors using Monte-Carlo method. (Pubmed Central) - Nov 22, 2019
The molecular fragments, which were promoter of endpoint increase or decrease were also determined. Thirteen new DGAT1 inhibitors were designed from the lead compound DGAT011.
- DGAT1: a novel and potent driver of melanoma growth and progression. () - Nov 21, 2019 - Abstract #SMR2019SMR_355;
Conversely, over-expression of DGAT1 increases formation of lipid droplets, and protects against cell death induced by both hypoxia and ROS inducing agents, while also increasing cellular proliferation through S6K. Overall these data demonstrate that DGAT1 plays a key and previously unappreciated role in melanoma development and progression.
- | Journal: Dietary macronutrient composition determines the contribution of DGAT1 to alcoholic steatosis. (Pubmed Central) - Nov 8, 2019
Overall these data demonstrate that DGAT1 plays a key and previously unappreciated role in melanoma development and progression. dietary macronutrient composition influences the relative contribution of DGAT1 and DGAT2 to alcoholic steatosis, such that in the context of alcohol and a high-fat diet, DGAT1 predominates.
- | PF-04620110 / Pfizer
Journal: PF-04620110, a Potent Antidiabetic Agent, Suppresses Fatty Acid-Induced NLRP3 Inflammasome Activation in Macrophages. (Pubmed Central) - Nov 7, 2019
dietary macronutrient composition influences the relative contribution of DGAT1 and DGAT2 to alcoholic steatosis, such that in the context of alcohol and a high-fat diet, DGAT1 predominates. Our results suggest that PF-04620110 suppresses fatty acid-induced NLRP3 inflammasome activation.
- | Journal: Genome wide association study identifies novel potential candidate genes for bovine milk cholesterol content. (Pubmed Central) - Nov 6, 2019
This is the first GWAS on bovine milk CHL. The identified markers and candidate genes need further validation in a larger cohort for use in the selection of cows with desired milk CHL content.
- | Journal: Scans for signatures of selection in Russian cattle breed genomes reveal new candidate genes for environmental adaptation and acclimation. (Pubmed Central) - Nov 2, 2019
We found genomic signatures of selective sweeps near key genes related to economically important traits, such as the milk production (e.g., DGAT1, ABCG2), growth (e.g., XKR4), and reproduction (e.g., CSF2). Our data point to candidate genes which should be included in future studies attempting to identify genes to improve the extant breeds and facilitate generation of commercial breeds that fit better into the environments of Russia and other countries with similar climates.
- | Journal: Identification of microRNAs involved in lipid biosynthesis and seed size in developing sea buckthorn seeds using high-throughput sequencing. (Pubmed Central) - Oct 30, 2019
An integrated analysis of mRNA and miRNA transcriptome and qRT-PCR identified some key miRNAs and their targets (miR164d-ARF2, miR168b-Δ9D, novelmiRNA-108-ACC, novelmiRNA-23-GPD1, novelmiRNA-58-DGAT1, and novelmiRNA-191-DGAT2) potentially involved in seed size and lipid biosynthesis of sea buckthorn seed. These results indicate the potential importance of miRNAs in regulating lipid biosynthesis and seed size in sea buckthorn.
- | Journal: Intrinsic disorder in the regulatory N-terminal domain of diacylglycerol acyltransferase 1 from Brassica napus. (Pubmed Central) - Oct 29, 2019
This domain interacts with allosteric modulators of DGAT1, CoA and oleoyl-CoA, at micromolar concentrations. While solution scattering studies indicate conformational heterogeneity in the N-terminal domain of DGAT1, there is a small gain of secondary structure induced by ligand binding.
- | Journal: The DGAT1 K232A polymorphism and feeding modify milk fat triacylglycerol composition. (Pubmed Central) - Oct 27, 2019
We show that, regardless of preference for DGAT1 genotype (AA or KK) and depending on the availability of FA according to season, UFA (C18:1 cis-9), short-chain FA (C6:0 and C10:0), and medium-chain FA might be esterified on the glycerol backbone of the TAG, keeping the structure characteristics of each TAG species. To our knowledge, this is the first report on the interaction effect of DGAT1 K232A polymorphism and season on the TAG composition in milk fat.