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8 Companies | 5 Products |
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5 Products | |
691 Diseases | |
2 Trials |  |
536 News |  |
- The anti-inflammatory and skin barrier function recovery effects of fermented Centella aisatica extract (Poster Zone) - Apr 21, 2024 - Abstract #EAACI2024EAACI_2561;
The 0.5% FCA containing cream had no irritation on the human skin by 24 hours single patch test. Conclusion From these results, FCA is proposed as a useful functional ingredient to alleviate atopic dermatitis through skin topical application and oral administration.
- | Journal: Diterpenoid WT-29 isolated from Wedelia exerted anti-inflammatory and anti-allergic activities. (Pubmed Central) - Nov 27, 2023
Conclusion From these results, FCA is proposed as a useful functional ingredient to alleviate atopic dermatitis through skin topical application and oral administration. WT-29 isolated from Wedelia exerts anti-inflammatory and anti-allergic effects mainly through NF-?B, Nrf2/Keap-1, MAPK pathways and regulating of autophagy, suggesting that it might be a potential anti-inflammatory and anti-allergic agent and could be used as medicine or health benefit product.
- GI-301 / GI Innovation, Yuhan Corp
Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of YH35324, a Novel Long-Acting High-Affinity IgETrap-Fc protein in Subjects with Atopy: Results from the First-in-Human Study (Poster Zone C) - Apr 30, 2023 - Abstract #EAACI2023EAACI_1143;
YH35324 rapidly suppressed serum free IgE level to a greater extent than omalizumab. Median duration of serum-free IgE concentration maintained at < 82.8 ng/mL increased with increasing dose of YH35342 and were longer in all YH35324 dose groups than in the omalizumab and placebo groups (P<0.05).
- Propolis (Exhibit Hall; Poster Board No. P715) - Apr 11, 2023 - Abstract #IMMUNOLOGY2023IMMUNOLOGY_1223;
Median duration of serum-free IgE concentration maintained at < 82.8 ng/mL increased with increasing dose of YH35342 and were longer in all YH35324 dose groups than in the omalizumab and placebo groups (P<0.05). Keywords: Propolis, mast cell, anaphylaxis, histamine,
- | Journal: Effects of G-Rh2 on mast cell-mediated anaphylaxis via AKT-Nrf2/NF-κB and MAPK-Nrf2/NF-κB pathways. (Pubmed Central) - Jul 15, 2022
Meanwhile, G-Rh2 reduced the levels of p-AKT, p38MAPK and Nrf2 in RBL-2H3 sensitized IgE cells and inhibited NF-κB signaling pathway activation by activating the AKT-Nrf2 and p38MAPK-Nrf2 pathways. G-Rh2 inhibits mast cell-induced allergic inflammation, which might be mediated by the AKT-Nrf2/NF-κB and p38MAPK-Nrf2/NF-κB signaling pathways.
- | Journal: Effects of Deacetylasperulosidic Acid on Atopic Dermatitis through Modulating Immune Balance and Skin Barrier Function in HaCaT, HMC-1, and EOL-1 Cells. (Pubmed Central) - Jun 23, 2021
Furthermore, DAA increased the expression of proteins involved in skin barrier functions such as filaggrin and involucrin in HaCaT cells. These results confirmed that DAA could relieve AD by controlling immune balance and recovering skin barrier function.
- | Journal: Humulene Inhibits Acute Gastric Mucosal Injury by Enhancing Mucosal Integrity. (Pubmed Central) - Jun 3, 2021
α-Humulene may attenuate HCl/ethanol-induced gastritis by inhibiting histamine release and NF-κB activation and stimulating antioxidants and mucosal protective factors, particularly Muc5ac and Muc6. Therefore, these data suggest that α-humulene is a potential drug candidate for the treatment of stress-induced or alcoholic gastritis.
- || Review, Journal: Anti-Allergic Rhinitis Effects of Medicinal Plants and Their Bioactive Metabolites via Suppression of the Immune System: A Mechanistic Review. (Pubmed Central) - May 1, 2021
The terms or keywords used to find relevant studies were allergic rhinitis OR pollinosis OR hay fever, AND medicinal plant OR single plant OR single herb OR phytotherapy. This comprehensive review serves as a useful resource for medicinal plants with anti-allergic rhinitis potential, understanding the underlying mechanisms of action and for future exploration to find natural product candidates in the development of novel anti-allergic rhinitis agents.
- | Journal: Tripterine is a potential anti-allergic compound. (Pubmed Central) - Feb 9, 2021
This comprehensive review serves as a useful resource for medicinal plants with anti-allergic rhinitis potential, understanding the underlying mechanisms of action and for future exploration to find natural product candidates in the development of novel anti-allergic rhinitis agents. TRI, as an active immunoregulatory factor, has great potential in the treatment of mast cell-mediated allergic diseases.
- | Journal: A novel MRGPRX2-targeting antagonistic DNA aptamer inhibits histamine release and prevents mast cell-mediated anaphylaxis. (Pubmed Central) - Dec 20, 2020
This study demonstrated that aptamer-X35 selected by the modified SELEX approach reduced histamine release by inhibiting the MRGPRX2 pathway. Overall, our findings establish aptamer-X35 as a potential therapeutic candidate against perioperative anaphylaxis.
- | Journal: The Effect of Aerosolized Chlorpheniramine Maleate on Exercise Induced Bronchospasm and Gas Exchange in Asthmatics. (Pubmed Central) - Aug 8, 2020
This study shows that Chlorpheniramine causes bronchodilation during resting period by acting on the circulating or tissue histamine in asthmatics which contributes to an increase in resting bronchomotor tone. As there is incomplete inhibition of EIA by Chlorpheniramine, there may be some other associated mediator release for pathogenesis of EIA.
- || Clinical, Journal: Efficacy and safety of So-Cheong-Ryong-Tang in patients with atopic dermatitis and respiratory disorders: Study protocol of a double-blind randomized placebo-controlled trial. (Pubmed Central) - Jan 30, 2020
This will be the first clinical trial to assess the efficacy and safety of SCRT in patients with AD and respiratory disorders. We hope that the results of this trial will provide evidence for the use of SCRT as a new treatment for AD with respiratory disorders.
- | Preclinical, Journal: Ethanol Induces Sedation and Hypnosis via Inhibiting Histamine Release in Mice. (Pubmed Central) - Aug 15, 2019
Neurochemistry experimental data indicated that ethanol inhibited histamine release in the FrCx in a dose-dependent manner. These findings suggest that ethanol induces sedation and hypnosis via inhibiting histamine release in mice.