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- || Review, Journal: An insight into the therapeutic effects of isoliquiritigenin in breast cancer. (Pubmed Central) - Nov 21, 2024
ILN emerges as a promising natural option, offering therapeutic advantages with minimal side effects. However, it is important to note that current research on ILN is primarily limited to preclinical models, underscoring the need for further investigation to validate its potential efficacy.
- | paclitaxel / Generic mfg.
Journal: FATS inhibits the Wnt pathway and induces apoptosis through degradation of MYH9 and enhances sensitivity to paclitaxel in breast cancer. (Pubmed Central) - Nov 18, 2024
Finally, we provide in vivo evidence that the combination of paclitaxel with IWR-1, a novel Wnt pathway inhibitor, synergistically suppresses breast cancer growth, laying the foundation for future trials with this drug combination. These results therefore provide a number of potential solutions for more precise treatment of patients with breast cancer in the future.
- | Journal: Dietary plant microRNAs as potential regulators of cellular cholesterol efflux. (Pubmed Central) - Nov 16, 2024
These results therefore provide a number of potential solutions for more precise treatment of patients with breast cancer in the future. Health-promoting properties attributed to cruciferous vegetables, might be mediated (at least in part) through miRNA-related mechanisms.
- | Preclinical, Journal: Airway epithelial cells promote in vitro airway smooth muscle cell proliferation by activating the Wnt/?-catenin pathway. (Pubmed Central) - Nov 16, 2024
This finding suggests that AECs may promote ASMCsproliferation by activating the Wnt pathway in ASMCs. The Wnt/?-catenin pathway appears to play an important role in ASMCs proliferation, indicating that future pathological studies should consider the potential involvement of the Wnt pathway in airway remodeling.
- | Journal: Basic Fibroblast Growth Factor Supports the Function of Limbal Niche Cells via the Wnt/?-Catenin Pathway. (Pubmed Central) - Nov 16, 2024
Wnt/?-catenin inhibitor LF3 treatment reversed the abovementioned effect of bFGF. bFGF could maintain and promote the stemness of LNC via the FGFR1/Wnt2/FZD7/LRP6 axis in a concentration-dependent manner.
- | XAV-939 / Novartis
Journal: Network toxicology and cell experiments reveal the mechanism of DEHP-induced diabetic nephropathy via Wnt signaling pathway. (Pubmed Central) - Nov 15, 2024
XAV-939 effectively mitigated these effects, underscoring the Wnt pathway's central role in DN progression under DEHP influence. These findings highlight the complex multi-target, multi-pathway interactions of DEHP in DN pathophysiology, offering deeper mechanistic insights and potential targets for therapeutic intervention against DEHP-induced nephrotoxicity.
- | Journal: Progranulin Facilitates Corneal Repair Through Dual Mechanisms of Inflammation Suppression and Regeneration Promotion. (Pubmed Central) - Nov 13, 2024
In conclusion, our findings underscored the potential of PGRN in facilitating corneal wound healing by promoting corneal epithelial cell proliferation, trigeminal ganglion cell axon regeneration, and suppressing ocular inflammation. These results suggest that PGRN could potentially expedite the healing process and improve visual outcomes in patients with corneal injuries.
- | Journal: TRIM25 activates Wnt/?-catenin signalling by destabilising MAT2A mRNA to drive thoracic aortic aneurysm development. (Pubmed Central) - Nov 7, 2024
IWR-1 partially counteracted the regulatory effects of shMAT2A. Collectively, TRIM25 destabilises the mRNA of MAT2A to activate Wnt/?-catenin signaling and ultimately exacerbate TAA injury.
- doxorubicin hydrochloride / Generic mfg.
Overcoming Immune Escape Via Targeting Akt-Wnt/?-Catenin By Artificial-Intelligence-Powered Peptide-Producing mRNAs (Marriott Grand Ballroom 2-4 (Marriott Marquis San Diego Marina)) - Nov 6, 2024 - Abstract #ASH2024ASH_1783;
Our lab previously discovered that low-dose doxorubicin (DXR) can selectively inhibit the Akt-mediated activation of ?-catenin...Overall, this innovative approach aims to modulate the signaling pathway, leading to the attenuation of ?-catenin's transcriptional activity. By targeting Wnt/?-catenin signaling, this approach holds the potential to influence the function of cancer stem cells and improve therapeutic responses in cancer treatment.
- | arecoline / Cogent Pharma
Journal: SFRP1 reduces neutrophil infiltration and inhibits the Wnt/?-catenin pathway to alleviate oral submucous fibrosis. (Pubmed Central) - Nov 4, 2024
We constructed an arecoline-induced OSF mice model...In vitro, the Wnt/?-catenin pathway activator further reversed the effect of SFRP1 overexpression on OSF. SFRP1 attenuates OSF by reducing neutrophil infiltration and inhibiting the Wnt/?-catenin pathway.
- | Journal: Associations of serum sclerostin levels with body composition, pulmonary function, and exacerbations in COPD patients. (Pubmed Central) - Nov 3, 2024
SOST levels are associated with body composition and lung function in patients with COPD. Furthermore, lower SOST levels predict a higher risk of exacerbations and hospitalization.
- | Journal: Targeting Wnt Pathways with Small Molecules as New Approach in Cardiovascular Disease. (Pubmed Central) - Nov 1, 2024
Many small-molecule inhibitors specifically target various components within the Wnt signaling pathways, such as Frizzled, Disheveled, Porcupine, and Tankyrase. This study aims to present an overview of the latest findings regarding the functions of Wnt signaling in human cardiac disorders and possible inhibitors of Wnt, which could lead to novel approaches for treating cardiac ailments.
- | Journal, IO biomarker: GPA33 expression in colorectal cancer can be induced by WNT inhibition and targeted by cellular therapy. (Pubmed Central) - Oct 30, 2024
GPA33-targeted therapy may be improved by simultaneous WNT inhibition to enhance GPA33 expression. Furthermore, GPA33 is a promising target for cellular immunotherapy in CRC.
- | Preclinical, Journal: The miR-665/SOST Axis Regulates the Phenotypes of Bone Marrow Mesenchymal Stem Cells and Osteoporotic Symptoms in Female Mice. (Pubmed Central) - Oct 27, 2024
miR-665 was down-regulated in osteoporotic BMSCs and up-regulated in osteogenically differentiated BMSCs. In conclusion, the miR-665/SOST axis modulates BMSC proliferation, osteogenic differentiation, and OVX-induced osteoporosis in mice, possibly through Wnt signaling.
- | Journal: Chemical and Biological Characterization of Metabolites from Silene viridiflora Using Mass Spectrometric and Cell-Based Assays. (Pubmed Central) - Oct 26, 2024
2-Deoxy-20-hydroxyecdysone with submicromolar IC50 was identified as a result. The structure-activity relationship derived from the data from the in vitro proliferation assay showed that the hydroxyl group present at position C-2 of steroid core reduces the ecdysteroids' cytotoxicity against cancer cells.
- | R-(-)-gossypol (AT 101) / Ascentage Pharma
Journal: Natural Small Molecule Compounds Targeting Wnt Signaling Pathway Inhibit HPV Infection. (Pubmed Central) - Oct 24, 2024
Wnt signaling pathway is involved in the process of HPV infection of host cells. 6-Gingerol, gossypol, tanshinone II2A, and EGCG inhibited HPV16-GFP pseudovirus infection and suppressed Wnt/?-catenin pathway in HaCat cells.
- | Zyclara (imiquimod) / Mochida, Viatris, Bausch Health
Journal: WIF-1 contributes to lupus-induced neuropsychological deficits via the CRYAB/STAT4-SHH axis. (Pubmed Central) - Oct 24, 2024
6-Gingerol, gossypol, tanshinone II2A, and EGCG inhibited HPV16-GFP pseudovirus infection and suppressed Wnt/?-catenin pathway in HaCat cells. In conclusion, WIF-1 exacerbates lupus-induced cognitive dysfunction in mice by triggering aberrant microglial activation and BBB disruption through the CRYAB/STAT4-SHH axis, highlighting the potential therapeutic effects of SDMA for the treatment of NPSLE.
- | Journal: Rebooting the Adaptive Immune Response in Immunotherapy-Resistant Lung Adenocarcinoma Using a Supramolecular Albumin. (Pubmed Central) - Oct 21, 2024
Furthermore, ABCA exhibits minimal adverse effects during treatment and high-dose toxicity tests, underscoring its excellent potential for clinical translation. Collectively, the present work possesses the potential to provide innovative perspectives on the advancement of optimized immunotherapies targeting drug resistance, while also presenting a promising avenue for translating Wnt inhibitors into immunotherapeutic drugs for their clinical application.
- | Journal: WNT1/ROR2 pathway enhances the Triple-Negative breast cancer invasion, migration, and Epithelial-Mesenchymal transition. (Pubmed Central) - Oct 21, 2024
Finally, the mouse model experiments further validated the anticancer effect of PP on TNBC. Generally speaking, the malignant progression of TNBC could be stimulated by the WNT1/ROR2 signaling pathway which can be inhibited by PP, suggesting the potential value of PP in controlling TNBC.
- | Journal: Knockdown of the Non-canonical Wnt Gene Prickle2 Leads to Cerebellar Purkinje Cell Abnormalities While Cerebellar-Mediated Behaviors Remain Intact. (Pubmed Central) - Oct 19, 2024
These structural cerebellar abnormalities did not impair cerebellar-associated behaviors as eyeblink conditioning and interval timing remained intact. Therefore, although Prickle mice show classic phenotypes of ASD, they do not recapitulate the involvement of the adult cerebellum and may not represent the pathophysiological heterogeneity of the disorder.
- Deciphering Neuronal Network Defects in Schizophrenia Using Microfluidic Cultures (Summit 2, 3rd Floor) - Oct 19, 2024 - Abstract #WCPG2024WCPG_30;
We identified hundreds of transcripts that were localized and enriched in the neurites with RNAseq. Gene ontology -term analysis highlighted mitochondrial and ribosomal function in the neurites, as well as biological processes related to translation and protein stability, synaptic signaling, axonal transport, and intracellular iron homeostasis, suggesting that translation in neurites is important in locally regulating these functions.
- || Review, Journal: Belling the "cat": Wnt/?-catenin signaling and its significance in future cancer therapies. (Pubmed Central) - Oct 17, 2024
Additionally, we have proposed strategies for future WNT/?-catenin-based drug discovery trials, emphasizing the potential of combination therapies and AI/ML-driven prediction approaches. Overall, here we showcased the opportunities, possibilities, and potentialities of WNT/?-catenin signaling modulatory therapeutic regimes as promising precision cancer medicines for the future.
- | Journal: Editorial: Natural products from plants or microorganisms for treatment of non- communicable diseases. (Pubmed Central) - Oct 16, 2024
Overall, here we showcased the opportunities, possibilities, and potentialities of WNT/?-catenin signaling modulatory therapeutic regimes as promising precision cancer medicines for the future. No abstract available
- | Journal: Asiaticoside Inhibits Growth and Metastasis in Non-Small Cell Lung Cancer by Disrupting EMT via Wnt/?-Catenin Pathway. (Pubmed Central) - Oct 15, 2024
Moreover, ATS administration repressed tumorigenesis in tumor-bearing mice. In conclusion, ATS represses growth and metastasis in NSCLC by blocking EMT via the inhibition of Wnt/?-catenin signaling.
- | 5-fluorouracil / Generic mfg.
Journal: Combinatorial Effects of 5-Fluorouracil and Menadione on Wnt/?-Catenin Pathway in Human Colorectal Cancer Cells. (Pubmed Central) - Oct 15, 2024
Docking and experimental results suggest that the drug combination interfered with key protein-protein interactions in the ?-catenin-TCF complex, exerted synergistic anti-cancerous effects in CRC cells, and downregulated the expression of Wnt signaling proteins. Taken together, our data suggest that the simultaneous binding of 5FU and menadione to ?-catenin can block Wnt signaling by disrupting ?-catenin-TCF interaction and inhibit the proliferation of CRC cells.
- | Journal: COLEC10 inhibits the stemness of hepatocellular carcinoma by suppressing the activity of ?-catenin signaling. (Pubmed Central) - Oct 13, 2024
Taken together, our data suggest that the simultaneous binding of 5FU and menadione to ?-catenin can block Wnt signaling by disrupting ?-catenin-TCF interaction and inhibit the proliferation of CRC cells. COLEC10 inhibits HCC stemness by downregulating the Wnt/?-catenin pathway, which is a promising target for liver CSC therapy.
- | Journal: O-GlcNAcylation mediates Wnt-stimulated bone formation by rewiring aerobic glycolysis. (Pubmed Central) - Oct 10, 2024
Mechanistically, Wnt3a induces O-GlcNAcylation at Serine 174 of PDK1 to stabilize the protein, resulting in increased glycolysis and osteogenesis. These findings highlight O-GlcNAcylation as an important mechanism regulating Wnt-induced glucose metabolism and bone anabolism.
- | Journal: Characterization of a chromatin-associated TCF7L1 complex in human embryonic stem cells. (Pubmed Central) - Oct 10, 2024
- | Journal: Implementation of a MSRE ddPCR method for the detection of methylated WIF1 and NPY genes in colorectal cancer patients. (Pubmed Central) - Oct 7, 2024
We implemented a ddPCR method to assess the methylation status of Wnt inhibitory factor 1 and neuropeptide y using the methylation sensitive restriction enzyme approach that does not impact on DNA quality and guarantees the discrimination of DNA methylation independent of bisulfite conversion. We showed that this method is robust and sensitive also allowing the monitoring of CRC disease progression when applied to circulating free DNA samples from liquid biopsies, proving to be a fast and easy to implement assay to be used for the monitoring of the methylation pattern of clinically relevant target genes.
- Cancer-associated fibroblast-derived Dickkopf-1 impairs anti-tumor immunity in breast cancer by suppressing NK cell-mediated cytotoxicity (Exhibit Halls AB - George R. Brown Convention Center) - Oct 4, 2024 - Abstract #SITC2024SITC_1529;
Samples were deidentified prior to sharing with collaborators. All studies were conducted in compliance with the Declaration of Helsinki.
- Cancer-associated fibroblast-derived Dickkopf-1 impairs anti-tumor immunity in breast cancer by suppressing NK cell-mediated cytotoxicity (Grand Ballroom AB - George R. Brown Convention Center) - Oct 4, 2024 - Abstract #SITC2024SITC_1526;
Samples were deidentified prior to sharing with collaborators. All studies were conducted in compliance with the Declaration of Helsinki.
- Cancer-associated fibroblast-derived Dickkopf-1 impairs anti-tumor immunity in breast cancer by suppressing NK cell-mediated cytotoxicity (George R. Brown Convention Center - Level 3 - Grand Ballroom B) - Oct 4, 2024 - Abstract #SITC2024SITC_1474;
Samples were deidentified prior to sharing with collaborators. All studies were conducted in compliance with the Declaration of Helsinki.
- | Journal: Nervonic acid improves fat transplantation by promoting adipogenesis and angiogenesis. (Pubmed Central) - Oct 4, 2024
In conclusion, the present study demonstrated that NA may not only stimulate adipogenesis by regulating signaling pathways in human MSCs, but could improve the outcome of fat transplantation by reducing inflammation and stimulating angiogenesis. It was thus hypothesized that NA could serve as an adjuvant strategy to enhance fat engraftment in regenerative surgery.
- | Journal: Establishment of goat mammary organoid cultures modeling the mammary gland development and lactation. (Pubmed Central) - Oct 1, 2024
This study is the first to establish a mammary organoid culture system modeling the mammary gland development and lactation process in ruminants. The efficient induction of lactation in ruminant mammary organoids holds promises for advancing the field of cell-based milk bio-manufacture in the food industry.
- | Niagen (nicotinamide riboside) / ChromaDex
Journal: Nicotinamide Riboside Promotes the Proliferation of Endogenous Neural Stem Cells to Repair Spinal Cord Injury. (Pubmed Central) - Oct 1, 2024
In addition, administration of Wnt pathway inhibitors also eliminated the proliferative effect of nicotinamide riboside. Collectively, these findings demonstrate that nicotinamide promotes the proliferation of neural stem cells by targeting the LGR5 gene to activate the Wnt pathway, which provides a new way to repair spinal cord injury.
- | Journal: miR-27a-3p regulates intestinal cell proliferation and differentiation through Wnt/?-catenin signalling. (Pubmed Central) - Sep 27, 2024
These alterations were attenuated or blocked by Wnt inhibition. Our study demonstrates an miR-27a-3p/RXR?/Wnt/?-catenin pathway that is important for the maintenance of enterocyte homeostasis in the small intestine.
- ADT-030 / ADT Pharma
A novel pan-RAS/?-catenin inhibitor, ADT-030, produces tumor regression in PDX models of pancreatic cancer (American Ballroom South) - Sep 26, 2024 - Abstract #AACRPanCa2024AACRPanCa_268;
ADT-030, novel dual pan-RAS/?-catenin inhibitor, showed strong and durable antitumor activity in clinically relevant and aggressive murine models of PDAC and lung cancer. ADT-030 is a promising development candidate for treatment of PDAC and other RAS-driven cancers, particularly given the complex KRAS mutation landscape of many cancers.
- Paracrine WNT Signaling Drives Pro-fibrotic Metabolic Activation of Systemic Sclerosis Macrophages (In Person) - Sep 25, 2024 - Abstract #ACRConvergence2024ACR_Convergence_3047;
Here we provide evidence for the emerging role of immunometabolic dysfunction in SSc. Our data suggest that paracrine WNT-signaling induces metabolic shift in M
- bleomycin / Generic mfg.
Secreted Frizzled-Related Protein 2 (sFRP2) Regulates Wnt Signaling to Affect Mesenchymal Transition of Lung Epithelial Cells Participates in Interstitial Lung Disease (In Person) - Sep 25, 2024 - Abstract #ACRConvergence2024ACR_Convergence_1767;
The SFRP2 gene is found to be excessively transcribed in the early stages of ILD and maintains high expression throughout the disease progression. 2.
- Uremic Toxin Indoxyl Sulfate Increases Osteocyte Wnt Inhibitor Signaling and Decreases RANKL and Mineralization, Effects Negated by PTH (Exhibit Hall, Convention Center) - Sep 23, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_3727;
In summary, IS in the absence of PTH, activated canonical and non-canonical AhR signaling to increase osteocyte Wnt inhibitor signaling and decrease RANKL osteoclast activation and mineralization, which would translate to low remodeling. However, in the presence of PTH, these effects were reversed, suggesting IS is likely an important factor in the low turnover bone disease observed in CKD.
- Wnt5a Promotes AKI to CKD Transition via p-JNK/Snai1 Signaling (Exhibit Hall, Convention Center) - Sep 23, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_2426;
However, in the presence of PTH, these effects were reversed, suggesting IS is likely an important factor in the low turnover bone disease observed in CKD. Our data revealed that Wnt5a is a key molecule mediating the progression from AKI to CKD, which shed light on the new Wnt5a/p-JNK/Snai1 pathway in AKI to CKD transition.
- foscenvivint (PRI724) / PRISM Pharma, Ohara Pharma, GSK2816126 / GSK
SALL1 Is Essential for Histone H3K27 Methyltransferase EZH2 to Regulate Apoptotic Responses in Kidney Ischemia-Reperfusion Injury (Exhibit Hall, Convention Center) - Sep 23, 2024 - Abstract #KIDNEYWEEK2024KIDNEY_WEEK_2420;
Our results indicate that silencing EZH2 can protect renal function by relieving transcriptional inhibition of SALL1, activating the Wnt/?-catenin pathway, and attenuating tubular epithelial apoptosis response. These results highlight the potential therapeutic value of targeting EZH2 in ischemia/reperfusion-induced AKI.
- || Review, Journal: Unravelling the Road to Recovery: Mechanisms of Wnt Signalling in Spinal Cord Injury. (Pubmed Central) - Sep 20, 2024
In this review, an attempt is made to dissect the impact of canonical and non-canonical Wnt pathways in relation to individual aspects of glial and fibrotic scar formation. Furthermore, it is also highlighted how modulating Wnt activity at chronic time points may aid in limiting lesion expansion and promoting axonal repair.
- || Review, Journal: Bone-fat linkage via interleukin-11 in response to mechanical loading. (Pubmed Central) - Sep 20, 2024
The increased circulating IL-11 acts like a hormone to enhance adipolysis as an energy source with a reduction in adipogenic differentiation via a suppression of Dkk1/2 expression in the adipose tissue. Such bone-fat linkage can be a mechanism whereby exercise increases bone mass and, at the same time, maintains energy supply from the adipose tissue.
- ||| WNT974 / Novartis
Trial completion: A Study of LGK974 in Patients With Malignancies Dependent on Wnt Ligands (clinicaltrials.gov) - Sep 20, 2024
P1, N=185, Completed, Sponsor: Novartis Pharmaceuticals
Such bone-fat linkage can be a mechanism whereby exercise increases bone mass and, at the same time, maintains energy supply from the adipose tissue. Active, not recruiting --> Completed
- | Journal: Teatime: epigallocatechin gallate targets fibroblast-epithelial cell crosstalk to combat lung fibrosis. (Pubmed Central) - Sep 20, 2024
Understanding and simultaneous targeting of interlinked signaling pathways, such as TGF-? and WNT, paves the road for future treatment options for pulmonary fibrosis.
- | Journal: The synergistic effect of phototherapy and active substances on hair growth. (Pubmed Central) - Sep 11, 2024
and IL-6) and cell pro apoptotic factor (TGF-?2) reduction, but also Wnt pathway inhibition by decreasing DKK1 level, and pro-hair growth factors (vascular endothelial growth factor (VEGF) and ?-catenin) increase. This innovative combination therapy offers a potential solution for the treatment of AGA, addressing both hormonal and cellular factors involved in hair loss.
- | Journal: Increased Activity of Epithelial Cdc42 Rho GTPase and Tight Junction Permeability in the Cftr Knockout Intestine. (Pubmed Central) - Sep 11, 2024
In contrast, inhibition of Cdc42 with ML141 increased permeability to both 3kD dextran and tight-junction impermeant 500 kD dextran in Cftr KO enteroids. These data suggest that increased constitutive Cdc42 activity may alter the stability of paracellular permeability in Cftr KO crypt epithelium.
- || Review, Journal: Blocking the WNT/?-catenin pathway in cancer treatment:pharmacological targets and drug therapeutic potential. (Pubmed Central) - Sep 10, 2024
The review provides a comprehensive understanding of inhibitors of WNT/?-catenin pathway in various cancer therapeutics. This will benefit novel WNT inhibitor development and optimal clinical use of WNT signaling-related drugs in synergistic cancer therapy.
- Altered epithelial Cdc42 Rho GTPase activity as an underlying cause of barrier permeability in Cftr KO intestine () - Sep 4, 2024 - Abstract #NACFC2024NACFC_1048;
Barrier integrity is maintained with moderate compromise in the absence of the CF intestinal environment. However, products of low-grade inflammation and dysbiosis (e.g., TNF-?, IL-1