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  • ||||||||||  Journal:  Early results of the integrative epigenomic-transcriptomic landscape of colorectal adenoma and cancer. (Pubmed Central) -  Mar 1, 2024   
    Finally, these findings emphasize the importance of assessing admixed populations to facilitate novel findings and alleviate disparities. Our results suggest that genome-wide alterations in DNA methylation occur during the early stages of CRC and demonstrate the methylation signatures associated with colorectal ADEs and CRC, suggesting prognostic biomarkers for CRC.
  • ||||||||||  Journal:  Alleviating hypertension by selectively targeting angiotensin receptor expressing vagal sensory neurons. (Pubmed Central) -  Mar 1, 2024   
    Here, we characterize the structure and function of vagal sensory neurons that express the angiotensin-II type 1a receptor (AT1aR) and provide evidence that these neurons are involved in blood pressure control. The implication is that AT1aR serve as a phenotypic marker for a subset of vagal baroreceptive neurons that may serve as a novel route to understand and alleviate hypertension.
  • ||||||||||  Review, Journal:  Autoantibodies Targeting G-Protein-Coupled Receptors: Pathogenetic, Clinical and Therapeutic Implications in Systemic Sclerosis. (Pubmed Central) -  Feb 28, 2024   
    This review aims to clarify the potential pathogenetic significance of GPCR-targeting autoantibodies in SSc, focusing on their associations with the different clinical manifestations of scleroderma. An extensive examination of functional autoimmunity targeting GPCRs might provide valuable insights into the underlying pathogenetic mechanisms of SSc, thus enabling the development of novel therapeutic strategies tailored to target GPCR-mediated pathways.
  • ||||||||||  Journal:  The Role of Local Angiotensin II/Angiotensin Type 1-receptor Mechanisms in Adipose Tissue Dysfunction to Promote Pancreatic Cancer. (Pubmed Central) -  Feb 13, 2024   
    Due to the role of local angiotensin II in the dysfunction of adipose tissue, angiotensin receptor blockers may be considered a new therapeutic strategy in the amelioration of the complications related to adipose tissue dysfunction and prevention of pancreatic cancer. This review aims to consider the biological roles of local angiotensin II and angiotensin II receptors in adipose tissue dysfunction to promote pancreatic cancer progression with a focus on adipose tissue inflammation and metabolic reprogramming.
  • ||||||||||  Actemra IV (tocilizumab) / Roche, JW Pharma
    Use of Tocilizumab for AT1R Antibody Mediated Rejection in a Heart Transplant Recipient (Poster Hall) -  Jan 9, 2024 - Abstract #ISHLT2024ISHLT_1677;    
    He was discharged with augmented maintenance immunosuppression (tacrolimus, sirolimus, & prednisone)...He was initiated on losartan for AT1R...Angiogram (LHC) following discontinuation demonstrated mild CAV whereas LHCs at 1-3y post HT demonstrated no vasculopathy (CAV).Summary We report a case of short term success using tocilizumab for non-HLA associated AMR due to AT1R. These results are promising, however, further study is needed to examine the short & long term treatment options for AT1R antibodies.
  • ||||||||||  hydrocortisone / Generic mfg.
    IMPACT OF ANGIOTENSIN II ON MORTALITY IN SEPTIC SHOCK () -  Jan 4, 2024 - Abstract #SCCM2024SCCM_2244;    
    Patients who received Ang2 had a lower in-hospital mortality and shorter ICU and hospital lengths of stay. Larger studies are necessary to determine statistical significance.
  • ||||||||||  Journal:  Genetic Variants Associated with High Susceptibility of Premature Ischemic Stroke. (Pubmed Central) -  Dec 3, 2023   
    We suggest that those polymorphisms should be determined in individuals with a family history of thrombosis to avoid the stroke development. Therefore, genotype-environmental combination could determine several possible phenotypes at different moments in life.
  • ||||||||||  Review, Journal:  Unraveling the relationship between the renin-angiotensin system and endometrial cancer: a comprehensive review. (Pubmed Central) -  Oct 24, 2023   
    Interestingly, the increased expression of AngII, AGTR1, and AGTR2 showed advancement in the stages and progression of EC via the prorenin/ATP6AP2 and AngII/AGTR1 pathway. Therefore, this review corresponds to unraveling the relationship between the progression and development of endometrial cancer with the dysfunction in the expression of various components associated with RAS in maintaining blood pressure.
  • ||||||||||  Journal:  Molecular docking analysis of AGTR1 antagonists. (Pubmed Central) -  Oct 9, 2023   
    These compounds were found to interact with crucial AGTR1 residues, indicating their potential as AGTR1 inhibitors. Moreover, the hit compounds demonstrated favorable drug-like characteristics and warrant further investigation for their potential use in managing CVD.
  • ||||||||||  Preclinical, Journal:  Diabetes-induced stimulation of the renin-angiotensin system in the rat brain cortex. (Pubmed Central) -  Sep 7, 2023   
    Thus, the aging-induced MPP1 exerts a previously unrecognized role in heart failure pathogenesis by upregulation of the angiotensin II AT1 receptor (AGTR1) protein. However, the AT1R level was increased in diabetic and hypertensive rats compared to controls, whereas the MAS receptor was downregulated (p
  • ||||||||||  Journal:  Association between AGTR1 (c.1166 A>C) Polymorphisms and Kidney Injury in Hypertension. (Pubmed Central) -  Aug 5, 2023   
    ogether, these data indicate that SFO and PVN contribute to blood pressure in the DOCA-salt model of hypertension through AT1aR signaling, while the DMV role was independent from AT1aR. Our study identified the relationship of AGTRA (c.1166 A>C) with hypertension combined with renal injury, and compared the susceptibility of different genetic models, which may provide novel targets for precision gene therapy of hypertension.
  • ||||||||||  Review, Journal:  The Role of Renin-Angiotensin System in Diabetic Cardiomyopathy: A Narrative Review. (Pubmed Central) -  Jul 29, 2023   
    Experimental studies also show beneficial effects for Ang-(1-7) and angiotensin-converting enzyme 2 infusion in improving heart functioning and tissue injury. Further research is necessary to fully understand the pathophysiology of diabetic cardiomyopathy and to translate experimental findings into clinical practice.
  • ||||||||||  Journal:  Identification of Cuproptosis Clusters and Integrative Analyses in Parkinson's Disease. (Pubmed Central) -  Jul 29, 2023   
    This study systematically evaluated the relationship between cuproptosis and PD and established a predictive model for assessing the risk of cuproptosis subtypes and the outcome of PD patients. This study provides a new understanding of PD-related molecular mechanisms and provides new insights into the treatment of PD.
  • ||||||||||  losartan / Generic mfg.
    Journal:  Unveiling Angiotensin II and Losartan-Induced Gene Regulatory Networks Using Human Urine-Derived Podocytes. (Pubmed Central) -  Jul 18, 2023   
    Co-stimulation with losartan and ANG II induced the exclusive expression of 106 genes associated with DNA methylation or demethylation, cell differentiation, the developmental process, response to muscle stretch, and calcium ion transmembrane transport. These findings highlight the usefulness of UdRPC-derived podocytes in studying the RAAS pathway and nephrotoxicity in various kidney diseases.
  • ||||||||||  Preclinical, Journal:  Ang-(1-7) attenuates podocyte injury induced by high glucose in vitro. (Pubmed Central) -  Jun 30, 2023   
    This study reveals that binding of Ang-(1-7) to its specific receptor MasR may counteract the effects of Ang II mediated by AT1R to significantly attenuate podocyte injury induced by high glucose. Ang-(1-7)/MasR targeting in podocytes may be a therapeutic approach to attenuate renal injury in DN.