Angiopoietin 1 inhib 
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  • ||||||||||  Journal:  Exploring the management of recurrent angioedema caused by different mechanisms. (Pubmed Central) -  Nov 28, 2024   
    For its potentially life-threatening and disfiguring features, angioedema should be promptly recognized and effectively treated. For this reason, enhancing awareness about various angioedema subtypes and their management provide a useful tool for the clinical practice.
  • ||||||||||  Journal:  One Copy Number Variation within the Angiopoietin-1 Gene Is Associated with Leizhou Black Goat Meat Quality. (Pubmed Central) -  Sep 29, 2024   
    Furthermore, the gain-of-copies genotype of CNV-1 demonstrated significant correlations with various phenotypic traits, including carcass weight, body weight, shear stress, chest circumference, and cross-sectional area of longissimus dorsi muscle. These findings indicate that the CNV-1 gain-of-copies genotype in the ANGPT1 gene may serve as a valuable marker for selecting Leizhou black goats exhibiting enhanced growth and muscular development characteristics, thereby holding potential applications in targeted breeding programs aimed at improving meat quality.
  • ||||||||||  Preclinical, Journal:  VEPTP inhibition with an extracellular domain targeting antibody did not restore albuminuria in a mouse model of diabetic kidney disease. (Pubmed Central) -  Sep 26, 2024   
    These findings indicate that the CNV-1 gain-of-copies genotype in the ANGPT1 gene may serve as a valuable marker for selecting Leizhou black goats exhibiting enhanced growth and muscular development characteristics, thereby holding potential applications in targeted breeding programs aimed at improving meat quality. Here, we show that VEPTP inhibition with an extracellular domain targeting VEPTP antibody induced Tie2 phosphorylation and improved VEGF-A induced vascular permeability both in
  • ||||||||||  Inflammatory and Angiogenic Serum Profile of Refractory Rheumatoid Arthritis (In Person) -  Sep 25, 2024 - Abstract #ACRConvergence2024ACR_Convergence_2002;    
    Moreover, refractory and active RA patients exhibited only few correlations with disease activity markers, despite the persistence of clinical and biological signs of disease activity. This may suggest that additional molecules may be implicated in refractory disease outside those herein selected.
  • ||||||||||  Review, Journal:  Research Advances in Neuroblast Migration in Traumatic Brain Injury. (Pubmed Central) -  Sep 20, 2024   
    However, the precise role of blood vessels in the migration of neuroblasts needs to be further explored. The in-depth study of neuroblast migration will most probably provide theoretical basis and breakthrough for the clinical treatment of brain injury diseases.
  • ||||||||||  dimethyl fumarate / Generic mfg.
    Review, Journal:  NINJ1: A new player in multiple sclerosis pathogenesis and potential therapeutic target. (Pubmed Central) -  Sep 17, 2024   
    Finally, the review examines potential therapeutic strategies targeting NINJ1 for improved MS management. Abbreviations: MS, Multiple sclerosis; CNS, Central nervous system; BBB, Blood-brain barrier; GSDMD, Gasdermin-D; EAE, Experimental autoimmune encephalitis; HMGB-1, High mobility group box-1 protein; LDH, Lactate dehydrogenase; PMR, Plasma membrane rupture; DMF, Dimethyl fumarate; DUSP1, Dual-specificity phosphatase 1; PAMPs, Pathogen-associated molecular patterns; DAMPs, Danger-associated molecular patterns; PRRs, Pattern recognition receptors; GM-CSF, Granulocyte-macrophage colony stimulating factor; IFN-?, Interferon gamma; TNF, Tumor necrosis factor; APCs, Antigen-presenting cells; ECs, Endothelial cells; TGF-?, Transforming growth factor-?; PBMCs, Peripheral blood mononuclear cells; FACS, Fluorescence-activated cell sorting; MCP-1, Monocyte chemoattractant protein-1; NLRP3, Pyrin domain-containing 3; TCR, T cell receptor; ROS, Reactive oxygen species; AP-1, Activator protein-1; ANG1, Angiopoietin 1; BMDMs, Bone marrow-derived macrophages; Arp2/3, actin-related protein 2/3; EMT, epithelial-mesenchymal transition; FAK, focal adhesion kinase; LIMK1, LIM domain kinase 1; PAK1, p21-activated kinases 1; Rac1, Ras-related C3 botulinum toxin substrate 1; ?-cat, ?-caten; MyD88, myeloid differentiation primary response gene 88; TIRAP, Toll/interleukin-1 receptor domain-containing adapter protein; TLR4, Toll-like receptor 4; IRAKs, interleukin-1 receptor-associated kinases; TRAF6, TNF receptor associated factor 6; TAB2/3, TAK1 binding protein 2/3; TAK1, transforming growth factor-?-activated kinase 1; JNK, c-Jun N-terminal kinase; ERK1/2, Extracellular Signal Regulated Kinase 1/2; IKK, inhibitor of kappa B kinase; I?B, inhibitor of NF-?B; NF-?B, nuclear factor kappa-B; AP-1, activator protein-1; ASC, Apoptosis-associated Speck-like protein containing a CARD; NEK7, NIMA-related kinase 7; NLRP3, Pyrin domain-containing 3; CREB, cAMP response element-binding protein.
  • ||||||||||  Journal:  Characterizing placental pericytes: Hypoxia and proangiogenic signalling. (Pubmed Central) -  Sep 15, 2024   
    Hypoxic conditions altered placental pericyte, endothelial, and syncytialized BeWo secretion of angiogenic factors. We speculate that pericyte dropout and, by extension, the loss of pericyte-derived angiogenic factors in hypoxic conditions may contribute to compromised fetal vascular development observed in placental pathologies.
  • ||||||||||  Journal:  HIF-1?-dependent regulation of angiogenic factor expression in M (Pubmed Central) -  Sep 12, 2024   
    Furthermore, RNA-sequencing analysis showed that the expression of angiogenesis-related pathway genes was upregulated by stretch stimulation. Our results thus suggest that mechanical stress induces VEGF production in M
  • ||||||||||  Journal:  Protein corona dynamicity contributes to biological destiny disparities of nanoparticles. (Pubmed Central) -  Sep 2, 2024   
    Moreover, the differential evolution of the two exPCs during cellular internalization leads to distinct autophagy and glycolysis activities, which can be attributed to the altered depletion of angiopoietin 1 during the formation of intracellular protein coronas, which ultimately impacts the PI3K/AKT-mTOR signaling. These findings offer valuable insights into the dynamic characteristics of exPCs during cellular internalization, and their consequential implications for cellular internalization and intracellular metabolism activity, which may facilitate the comprehension of PCs on biological effects of NPs and expedite the design and application of biomedical nanoparticles.
  • ||||||||||  Preclinical, Journal:  Platelet Angiopoietin-1 Protects Against Murine Models of Tumor Metastasis. (Pubmed Central) -  Aug 21, 2024   
    Serum from Angpt1Plt KO mice increased endothelial permeability and reduced VE-cadherin expression at endothelial junctions compared with serum from control mice (Angpt1WT). Platelets provide an intravascular source of Angpt1 that restrains tumor metastasis by preserving the lung microvasculature to limit tumor cell extravasation.
  • ||||||||||  Review, Journal:  Roles of astrocytic sonic hedgehog production and its signal for regulation of the blood-brain barrier permeability. (Pubmed Central) -  Jul 20, 2024   
    Furthermore, activation of astrocytic Shh signaling reduces reactive astrogliosis, neuroinflammation, and increases the production of vascular protective factors, which alleviates BBB disruption in the damaged brain. These findings suggest that astrocytic Shh and Shh signaling protect BBB function in the damaged brain and that target drugs for Shh signaling are expected to be novel therapeutic drugs for acute brain injuries.
  • ||||||||||  Biomarker, Journal, IO biomarker:  Potential biomarkers for multiple sclerosis stage from targeted proteomics and microRNA sequencing. (Pubmed Central) -  Jul 9, 2024   
    Conversion to secondary progressive disease is marked by a peak in granzyme B levels and enrichment for immune-related microRNAs. This indicates that specific immune cell-driven processes may contribute to the conversion of relapsing-remitting multiple sclerosis to secondary progressive multiple sclerosis.
  • ||||||||||  Dysregulated Angiopoietin-Tie signalling contributes to neurovascular dysfunction in Alzheimer (Exhibit (Pennsylvania Convention Center); In-Person) -  Jun 19, 2024 - Abstract #AAIC2024AAIC_4451;    
    The expression of the stabilising receptor, TIE-2, was reduced in early-stage AD and ANGPT2 expression was differentially related to perfusion and BBB leakiness dependent on disease stage. The study highlights important differences in ANGPT/TIE signalling in relation to disease stage and illustrates a complex relationship between brain, microvascular, and CSF changes that warrants further investigation.
  • ||||||||||  Biomarker, Journal:  Changes in plasma concentrations of novel vascular and inflammatory biomarkers in obstructive sleep apnea patients pre- and post-stroke. (Pubmed Central) -  Jun 16, 2024   
    The study highlights important differences in ANGPT/TIE signalling in relation to disease stage and illustrates a complex relationship between brain, microvascular, and CSF changes that warrants further investigation. In summary, our study has identified a novel set of plasma biomarkers including PDGF-AA, CXCL10 and Ang-1 for their potential prognostic value for disease outcomes pre- and post-stroke in OSA patients and use as surrogate markers to measure efficacy of treatment modalities.
  • ||||||||||  Biomarker, Clinical, Review:  Angiopoietin as A Novel Prognostic Marker in Kidney Disease. (Pubmed Central) -  Jun 3, 2024   
    This pilot work demonstrates that acute exercise modulated two-hit hypothesis mediators associated with GI bleeding in patients with CF-LVADs. There is a need for further large-scale randomized clinical trials in order to have a better understanding of the significance of angiopoietin-2 and for the determination of its potential clinical implications.
  • ||||||||||  ALTERED SERUM INFLAMMATORY AND ANGIOGENIC SIGNATURES IN REFRACTORY RHEUMATOID ARTHRITIS () -  May 29, 2024 - Abstract #EULAR2024EULAR_3406;    
    These results highlight the potential constraints of serum analysis in refractory RA. The lack of correlations between serum markers, CRP, and DAS28, in contrast to active non-refractory RA, may provide insights into the treatment resistance observed in refractory RA, especially in the context of therapies targeting angiogenesis and inflammation molecules.
  • ||||||||||  Vabysmo (faricimab-svoa) / Roche
    Review, Journal:  Beyond VEGF: Angiopoietin-Tie Signaling Pathway in Diabetic Retinopathy. (Pubmed Central) -  May 25, 2024   
    Short term outcomes of previously treated and treatment-naive eyes with DME that were treated with faricimab during routine clinical practice suggest a beneficial effect of faricimab over other agents. Targeting of Ang2 has been reported by several other means including VE-PTP inhibitors, integrin binding peptide and surrobodies.