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- | Journal: Physiopathology of late-onset fetal growth restriction. (Pubmed Central) - Oct 30, 2021
Another hypothesis suggests that the change in the trophoblastic invasion of spiral arteries would be milder. In this article, we address the main mechanisms described in the pathophysiology of FGR and, later, the specific findings in late-onset FGR.
- | Journal: Transcryptomic Analysis of Human Brain -Microvascular Endothelial Cell Driven Changes in -Vascular Pericytes. (Pubmed Central) - Oct 30, 2021
Taken together, we provide first evidence that interaction with ECs though porous membranes induces major changes in the transcriptomic and proteomic profile of PCs. ECs influence genes involved in diverse aspects of PC function including PC maturation, cell survival, anti-viral defense, blood flow regulation, immuno-modulation and ECM deposition.
- | glibenclamide / Generic mfg.
Preclinical, Journal: Efficiency of Gymnema sylvestre-derived gymnemic acid on the restoration and improvement of brain vascular characteristics in diabetic rats. (Pubmed Central) - Oct 30, 2021
Rats were divided into five groups, including control, gymnemic control rats (CGM), rats that were rendered diabetic by single injection of 60 mg/kg streptozotocin (STZ), diabetic rats treated with 400 mg/kg GM (STZ + GM) and diabetic rats treated with 4 mg/kg glibenclamide (GL; STZ + GL)...Furthermore, VEGF expression and Ang-1 secretion decreased in the STZ + GM group compared with STZ rats. The results of the present study revealed that GM treatment decreased blood vessel damage in the brain, suggesting that it may be used as a therapeutic target for the treatment of diabetes.
- || Clinical, Journal: Endothelial Dysfunction as a Component of Severe Acute Respiratory Syndrome Coronavirus 2-Related Multisystem Inflammatory Syndrome in Children With Shock. (Pubmed Central) - Oct 28, 2021
P=N/A
The results of the present study revealed that GM treatment decreased blood vessel damage in the brain, suggesting that it may be used as a therapeutic target for the treatment of diabetes. Endothelial dysfunction is associated with severe acute respiratory syndrome coronavirus 2-related multisystem inflammatory syndrome in children with shock and may constitute one of the underlying mechanisms.
- | Journal, PARP Biomarker: Autophagy Activation by Resveratrol Reduces Severity of Experimental Rheumatoid Arthritis. (Pubmed Central) - Oct 27, 2021
Dietary supplementation with resveratrol induces the non-canonical autophagy pathway and limits the cross-talk existence with inflammation, which in consequence modulates the synovial hyperplasia. Preventive strategies that incorporate dietary intervention with resveratrol may offer a potential therapeutic alternative to drugs to influence the risk of RA and influence its course.
- | fingolimod / Generic mfg.
Journal: FTY720 (Fingolimod), a modulator of sphingosine-1-phosphate receptors, increases baseline hypothalamic-pituitary adrenal axis activity and alters behaviors relevant to affect and anxiety. (Pubmed Central) - Oct 27, 2021
The antidepressant-like and anxiolytic-like effects of FTY720 may be attributed to reduced vascular remodeling as increased stress-induced blood vessel density in the brain contributes to behavior associated with vulnerability in rats. Together, these results demonstrate that FTY720 regulates baseline HPA axis activity but reduces social anxiety and despair, providing further evidence that S1PRs are important and novel regulators of stress-related functions.
- | Journal: Genetic variation implicates plasma angiopoietin-2 in the development of acute kidney injury sub-phenotypes. (Pubmed Central) - Oct 15, 2021
Together, these results demonstrate that FTY720 regulates baseline HPA axis activity but reduces social anxiety and despair, providing further evidence that S1PRs are important and novel regulators of stress-related functions. Genetic mediation analysis provides supportive evidence that angiopoietin-2 plays a causal role in risk for AKI-SP2.
- | Preclinical, Journal: Adjusting vascular permeability, leukocyte infiltration, and microglial cell activation to rescue dopaminergic neurons in rodent models of Parkinson's disease. (Pubmed Central) - Oct 10, 2021
The combination of C16 and Ang-1 yielded better results compared to the individual drugs alone in terms of reducing dopaminergic neuronal apoptosis, ameliorating cognitive impairment, and electrophysiological dysfunction, attenuating inflammation in the CNS microenvironment, and improving the functional disability in PD mice or rats. These results suggest neuroprotective and anti-inflammatory properties of the C16 peptide plus Ang-1 in PD.
- || Biomarker, Clinical, Journal: The ratio of plasma angiopoietin-2 to angiopoietin-1 as a prognostic biomarker in patients with sepsis. (Pubmed Central) - Oct 9, 2021
These results suggest neuroprotective and anti-inflammatory properties of the C16 peptide plus Ang-1 in PD. Plasma Angpt-2 was related to cytokines, but Angpt-2/1 ratio was a good predictor of 28-day mortality in patients with sepsis.
- | Journal: Temporal Dysregulation of the Angiopoietin-2/-1 Ratio After Trauma and Associations With Injury Characteristics and Outcomes. (Pubmed Central) - Oct 8, 2021
In this study, we demonstrate novel temporal associations between angiopoietin dysregulation and blunt injuries, acute coagulopathy, and hemorrhagic shock. Moreover, our findings highlight the presence of endothelial activation following traumatic insults in adults that may contribute to worse clinical outcomes.
- || Clinical, Journal: Autotaxin Activity Predicts 30 Day Mortality in Sepsis Patients and Correlates With Platelet Count and Vascular Dysfunction. (Pubmed Central) - Oct 8, 2021
Platelet count, the ratio of angiopoietin-2/1, and autotaxin activity all predicted 30 day mortality. Autotaxin activity within the plasma correlates with both platelet counts and vascular dysfunction biomarkers across both survivors and non-survivors indicating a possible involvement of autotaxin within sepsis.
- | Journal: Microtubule Stabilization Promotes Microcirculation Reconstruction After Spinal Cord Injury. (Pubmed Central) - Oct 6, 2021
Taken together, this study provides evidence for the mechanisms underlying the promotion of microcirculation reconstruction after SCI by microtubule stabilization treatment. Importantly, this study suggests the potential of microtubule stabilization as a therapeutic target to reduce microcirculation dysfunction after SCI in the clinic.
- [VIRTUAL] Low Levels Of Serum Angiopoietin-1 Are Associated With Benign And Malignant Thyroid Disease () - Oct 5, 2021 - Abstract #ACSCLINCON2021ACS_CLINCON_773;
Lower levels of Ang-1 are associated with benign and malignant thyroid disease. Further studies are required to establish whether Ang-1 can be utilized as a biomarker for thyroid disease.
- temozolomide / Generic mfg.
Changes in proteomic markers after injections of personal AV-GBM-1 dendritic cell/tumor initiating cell vaccines in a phase II trial in patients with newly diagnosed glioblastoma (Poster Hall) - Oct 1, 2021 - Abstract #SITC2021SITC_370;
P2
More sophisticated analyses of this data set, such as principal component analysis, may be needed to understand the effects of AV-GBM-1. Clinicaltrials gov NCT03400917
- || Clinical, Journal: Association between delay in intensive care unit admission and the host response in patients with community-acquired pneumonia. (Pubmed Central) - Sep 30, 2021
P=N/A
Clinicaltrials gov NCT03400917 Blood leukocytes of CAP patients with delayed ICU admission show evidence of a more immune suppressive phenotype upon ICU admission when compared with blood leukocytes from patients directly transferred to the ICU.
- | Journal: Pathophysiology and underlying mechanisms in Hereditary Angioedema. (Pubmed Central) - Sep 30, 2021
Blood leukocytes of CAP patients with delayed ICU admission show evidence of a more immune suppressive phenotype upon ICU admission when compared with blood leukocytes from patients directly transferred to the ICU. No abstract available
- | Journal: Definition and classification of hereditary angioedema. (Pubmed Central) - Sep 29, 2021
It is possible that, after an initial workup, a patient without a family history of HAE could be classified with an acquired form of angioedema (nonhereditary) that may later prove to be HAE due to a de-novo SERPING1 mutation. Because there are forms of nonhistaminergic (H-antihistamine unresponsive) angioedema that appear clinically very similar to HAE, it is essential that the patient undergoes a thorough clinical history and diagnostic evaluation to ensure that he or she is properly diagnosed and classified.
- | Journal: Hereditary angioedema: Pathophysiology (HAE type I, HAE type II, and HAE nC1-INH). (Pubmed Central) - Sep 29, 2021
The alterations in FXII and plasminogen (also a serine protease inhibited by C1-INH) like with classic HAE are the result of dysregulation of bradykinin generation. Only genetic alterations in angiopoietin-1 may not be related to bradykinin generation, rather related to the control of the effect of bradykinin on the vascular endothelium.
- | Tracleer (bosentan) / J&J, Roche
Preclinical, Journal: Endothelin receptor antagonists alleviate blood-brain barrier disruption and cerebral edema in a mouse model of traumatic brain injury: A comparison between bosentan and ambrisentan. (Pubmed Central) - Sep 25, 2021
FPI-induced alterations of the expression levels of matrix metalloproteinase-9, vascular endothelial growth factor-A, and angiopoietin-1 in the mouse cerebrum were reduced by delayed administration of bosentan, while ambrisentan had no significant effects. These results suggest that ET antagonists are effective in improving BBB disruption and cerebral edema in TBI patients and that an ET/ET non-selective type of antagonists is more effective.
- | Journal: RNA-binding protein SAMD4A inhibits breast tumor angiogenesis by modulating the balance of angiogenesis program. (Pubmed Central) - Sep 16, 2021
Mechanistically, SAMD4A was found to specifically destabilize the proangiogenic gene transcripts, including C-X-C motif chemokine ligand 5 (CXCL5), endoglin (ENG), interleukin 1β (IL1β), and angiopoietin 1 (ANGPT1), by directly interacting with the stem-loop structure in the 3' untranslated region (3'UTR) of these mRNAs through its Sterile Alpha Motif (SAM) domain, resulting in the imbalance of angiogenic genes expression. Collectively, our results suggest that SAMD4A is a novel breast tumor suppressor that inhibits tumor angiogenesis by specifically downregulating the expression of proangiogenic genes, which might be a potential anti-angiogenic target for breast cancer therapy.
- | Preclinical, Journal: IGFBP-4 enhances VEGF-induced angiogenesis in a mouse model of myocardial infarction. (Pubmed Central) - Sep 15, 2021
Our findings demonstrate that VEGF treatment alone is often not enough to protect against oxidative stress and promote post-ischemic angiogenesis, whereas the combined treatment with IGFBP4 and VEGF can utilize the dual roles of these agents to effectively protect against ischemic and oxidative injury, and promote angiogenesis. These findings provide important insights into the roles of these agents in the clinical setting, and suggest new strategies in the treatment of ischemic heart disease.
- | Journal: Mucopolysaccharide polysulfate promotes microvascular stabilization and barrier integrity of dermal microvascular endothelial cells via activation of the angiopoietin-1/Tie2 pathway. (Pubmed Central) - Sep 15, 2021
We found that MPS promoted microvascular stabilization and barrier integrity in HDMEC via Ang-1/Tie2 activation. These results suggest that MPS might improve microvascular abnormalities in various diseases accompanied by disturbances in Ang-1/Tie2 signaling.
- || tranexamic acid oral / Generic mfg.
Clinical, Journal: Early Tranexamic Acid Administration After Traumatic Brain Injury Is Associated With Reduced Syndecan-1 and Angiopoietin-2 in Patients With Traumatic Intracranial Hemorrhage. (Pubmed Central) - Sep 12, 2021
TXA may inhibit early upregulation of syndecan-1 and angiopoietin-2 in patients with MS-TBI, suggesting attenuation of protease-mediated vascular glycocalyx breakdown. The findings of this exploratory analysis should be considered preliminary and require confirmation in future studies.
- | Journal: Sodium tanshinone IIA sulfonate ameliorates cerebral ischemic injury through regulation of angiogenesis. (Pubmed Central) - Sep 11, 2021
In conclusion, STS protected against ischemic brain injury by promoting angiogenesis in ischemic areas and inhibiting neuronal apoptosis. These results provide a potential treatment for stroke recovery.
- | atorvastatin / Generic mfg.
Preclinical, Journal, IO biomarker: Atorvastatin pretreatment alleviate the ischemic brain injury linked to peroxisome proliferator-activated receptor coactivator-1α and angiogenic factors in diabetic mice. (Pubmed Central) - Sep 11, 2021
These results provide a potential treatment for stroke recovery. Impaired angiogenesis mediated by PGC-1α plays an important role in exacerbating ischemic cerebral insults in diabetic mice, and pretreatment with atorvastatin before MCAO has a protective effect through the regulation of PGC-1α and angiogenic factors.
- || Clinical, Journal: Enhancing the cardiovascular protective effects of a healthy dietary pattern with wolfberry (Lycium barbarum): A randomized controlled trial. (Pubmed Central) - Sep 9, 2021
P=N/A
Incorporating wolfberry to the diet further improves blood lipid-lipoprotein profile and may lower long-term CVD risk. This study was registered at clinicatrials.gov as NCT03535844.
- A Rare Case of Blue Rubber Bleb Nevus Syndrome (Shoreline Exhibit Hall) - Sep 8, 2021 - Abstract #ACG2021ACG_78;
Severe disease associated with bleeding should be treated with blood transfusions. Refractory disease may benefit from surgical resection of the affected bowel.This case serves to show that BRBNS, although rare, can present in the gastrointestinal system without involvement of other organ systems.Figure: Endoscopy showing multiple nevi in colon
- || Clinical, Journal: Angioedema without urticaria: novel findings which must be measured in clinical setting. (Pubmed Central) - Sep 5, 2021
The validation of biomarkers for the contact system activation could be beneficial in differentiating bradykinin - from histaminergic-mediated angioedema. Currently, the available laboratorial tests are still somewhat restricted to the evaluation of the complement activation and the mediators of nonhistaminergic and nonbradykinin-mediated angioedema remain to be identified.
- || Clinical, Journal: Plasma cytokines for predicting diabetic retinopathy among type 2 diabetic patients via machine learning algorithms. (Pubmed Central) - Sep 5, 2021
Currently, the available laboratorial tests are still somewhat restricted to the evaluation of the complement activation and the mediators of nonhistaminergic and nonbradykinin-mediated angioedema remain to be identified. Plasma angiopoietin 1, platelet-derived growth factor-BB, and vascular endothelial growth factor receptor 2 were associated with presence of non-proliferative diabetic retinopathy and may be good biomarkers that play important roles in pathophysiology of diabetic retinopathy.
- | Journal: CD34+CD146+ adipose-derived stromal cells enhance engraftment of transplanted fat. (Pubmed Central) - Sep 4, 2021
We have identified a subpopulation of CD34+ ASCs with enhanced angiogenic effects in vitro and in vivo, likely mediated by increased expression of potent proangiogenic factors. These findings suggest that enriching lipoaspirate with CD34+CD146+ ASCs may enhance fat graft vascularization and retention in the clinical setting.
- | Journal: Mesenchymal stem/stromal cells and their extracellular vesicle progeny decrease injury in post-stenotic swine kidney through different mechanisms. (Pubmed Central) - Sep 4, 2021
MSCs more effectively preserved the microcirculation, while EV bestowed better preservation of renal cellular integrity. These findings encourage further exploration of this novel approach to attenuate renal injury.
- || Review, Journal: Advances of Angiopoietin-Tie axis in vascular and lymphatic system-related diseases (Pubmed Central) - Sep 3, 2021
In light of the recent advances on the role of the Ang-Tie axis in vascular and lymphatic system-related diseases, this review summarizes the functions of the Ang-Tie axis in inflammation-induced vascular permeability, vascular remodeling, ocular angiogenesis, shear stress response, atherosclerosis, tumor angiogenesis, and metastasis. Moreover, this review summarizes the relevant therapeutic antibodies, recombinant proteins, and small molecular drugs associated with the Ang-Tie axis.
- || Clinical, Journal: Hypoxia-inducible factor 1-alpha enhances the secretome to rejuvenate adult cardiosphere-derived cells. (Pubmed Central) - Sep 2, 2021
Hypoxia-inducible factor-1α improves the functional potency of cardiosphere-derived cells to preserve myocardial function after myocardial infarction by enriching the cardiosphere-derived cells' secretome with cardioprotective factors. This strategy may be useful for improving the efficacy of allogeneic cell-based therapies in future clinical trials.
- | Journal: Bone Marrow Endothelial Cells Regulate Myelopoiesis in Diabetes. (Pubmed Central) - Sep 1, 2021
Specifically, diabetes reduces endothelial production of Cxcl12, a quiescence-promoting niche factor that reduces stem cell proliferation. We also describe a previously unknown counter-regulatory pathway, in which protective endothelial Egfr signaling curbs HSPC proliferation and myeloid cell production.
- | Journal: In Uveal Melanoma, Angiopoietin-2 but Not Angiopoietin-1 Is Increased in High-Risk Tumors, Providing a Potential Druggable Target. (Pubmed Central) - Aug 28, 2021
IHC showed that ANG-2 was expressed in macrophages as well as tumor cells. The presence of ANG-2 in the tumor and in aqueous humor, especially in high-risk tumors, make ANG-2 a potential targetable cytokine in uveal melanoma.
- | Journal: Effect of erythropoietin on angiogenic potential of dental pulp cells. (Pubmed Central) - Aug 28, 2021
Furthermore, EPO activated the ERK1/2 and p38 signaling pathways in DPCs, while inhibition of these pathways diminished the angiogenesis capacity of DPCs. The present study suggested that EPO may have an important role in the repair and regeneration of dental pulp.
- | Preclinical, Journal: Exosomal lncRNA-H19 promotes osteogenesis and angiogenesis through mediating Angpt1/Tie2-NO signaling in CBS-heterozygous mice. (Pubmed Central) - Aug 25, 2021
Treatment of BMMSC-Exo also restored the bone formation and mechanical quality in vivo. These findings provide a novel insight into how the extracellular role of exosomal lnc-H19 affects osteogenesis and angiogenesis through competing endogenous RNA networks.
- | sirolimus / Generic mfg.
Journal: Angiopoietin-1 protects neurons by inhibiting autophagy after neuronal oxygen-glucose deprivation/recovery injury. (Pubmed Central) - Aug 18, 2021
Neuronal viability was detected by using the Cell Counting Kit-8, which was then used to select the appropriate concentration of Ang-1 and rapamycin used in the OGD/R injury model...Ang-1 appears to have a neuroprotective role by inhibiting autophagy expression in OGD/R. Thus, these findings could be useful for the treatment of OGD/R injury.
- | Journal: Angiopoietin-1 is associated with a decreased risk of lymph node metastasis in early stage cervical cancer. (Pubmed Central) - Aug 15, 2021
ANG1 is associated with a significantly decreased risk of LNM in early stage cervical cancer. The predictive value and role of ANG1 in LNM needs to be further investigated in future studies.
- | Journal: Endoglin deficiency impairs VEGFR2 but not FGFR1 or TIE2 activation and alters VEGF-mediated cellular responses in human primary endothelial cells. (Pubmed Central) - Aug 15, 2021
In contrast, bFGF, angiopoietin-1 and -2 induced HUVEC migration and anti-apoptotic activities were not affected by ENG knockdown. In conclusion, ENG deficiency alters the VEGF/VEGFR2 pathway, which may play a role in HHT pathogenesis.
- | Journal: Short- and Long-Term Stability of Plasma Rich in Growth Factors Eye Drops. (Pubmed Central) - Aug 14, 2021
PRGF eye drops can be stored for up to 12 months without reduction of the main growth factors and proteins and without any microbial contamination. Furthermore, the biological activity of the PRGF eye drops is maintained after storing for 3 and 7 days at 4°C or at RT.
- | Journal: ETS1, ELK1, and ETV4 Transcription Factors Regulate Angiopoietin-1 Signaling and the Angiogenic Response in Endothelial Cells. (Pubmed Central) - Aug 13, 2021
Moreover, ETS1, ELK1, and ETV4 knockdown inhibited Ang-1-induced upregulation of thirteen, eight, and nine pro-angiogenesis genes, respectively. We conclude that ETS1, ELK1, and ETV4 transcription factors play significant angiogenic roles in Ang-1 signaling in ECs.
- | Journal: Sensory neurons from dorsal root ganglia regulate endothelial cell function in extracellular matrix remodelling. (Pubmed Central) - Aug 13, 2021
Our results suggest a role of sensory neurons, and more specifically of CGRP and SP, in the remodelling of endothelial cells extracellular matrix, thus supporting and enhancing the angiogenesis process. Video abstract.
- | Journal: Dysregulation of angiopoietin-1 and angiopoietin-2 in an infant with fatal Clarkson disease. (Pubmed Central) - Aug 13, 2021
Video abstract. No abstract available
- | Journal: Upregulation of pulmonary tissue factor, loss of thrombomodulin and immunothrombosis in SARS-CoV-2 infection. (Pubmed Central) - Aug 12, 2021
Upregulation of pulmonary TF with loss of thrombomodulin emerge as a potential link to immunothrombosis, and therapeutic targets in the disease. John Hopkins University School of Medicine.
- | Preclinical, Journal: Intracavernous delivery of Dickkopf3 gene or peptide rescues erectile function through enhanced cavernous angiogenesis in the diabetic mouse. (Pubmed Central) - Aug 11, 2021
DKK3 restored cavernous vascular integrity and improved erectile function in diabetic mice. Therapeutic cavernous angiogenesis by use of DKK3 will be a promising therapeutic strategy to treat diabetic erectile dysfunction.
- | Biomarker, Journal: Prognostic role of plasma level of angiopoietin-1, angiopoietin-2, and vascular endothelial growth factor in hepatocellular carcinoma. (Pubmed Central) - Aug 10, 2021
Therapeutic cavernous angiogenesis by use of DKK3 will be a promising therapeutic strategy to treat diabetic erectile dysfunction. The plasma levels of Ang-2 correlated with liver function, tumor stage, and tumor invasiveness, showing better performance in predicting OS and PFS than AFP, Ang-1, or VEGF.
- | Preclinical, Journal: Vasohibin-1 rescues erectile function through up-regulation of angiogenic factors in the diabetic mice. (Pubmed Central) - Aug 8, 2021
The induction of angiogenic factors, such as angiopoietin-1 and vascular endothelial growth factor, is responsible for cavernous angiogenesis and the restoration of erectile function mediated by VASH1. Altogether, these findings suggest that VASH1 is proangiogenic in diabetic penis and is a new potential target for diabetic ED.
- || Clinical, Journal: Screening for Plasminogen Mutations in Hereditary Angioedema Patients. (Pubmed Central) - Aug 5, 2021
As shown by this study, a biorepository creates the means for the ex-post analysis of recently identified genes in stored DNA samples of the patients. This makes the diagnosis more accurate with the possibility of subsequent family screening and the introduction of appropriate therapy.
- || Clinical, Clinical protocol, Journal: Effect of the oXiris membrane on microcirculation after cardiac surgery under cardiopulmonary bypass: study protocol for a randomised controlled trial (OXICARD Study). (Pubmed Central) - Aug 5, 2021
P=N/A
Results of the study will be disseminated via peer-reviewed publications and presentations at national and international conferences. NCT04201119.