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- | Journal: Influence of traumatic brain injury on extracellular tau elimination at the blood-brain barrier. (Pubmed Central) - Feb 22, 2022
Lastly, angiopoietin-1, a mural cell-derived protein governing endothelial Mfsd2a expression, was secreted from r-mTBI cerebrovessels to a greater extent than r-sham animals. Altogether, in the chronic phase post-injury, release of angiopoietin-1 from degenerating mural cells downregulates caveolin-1 expression in brain endothelia, resulting in decreased tau elimination across the BBB, which may describe the accumulation of tau species in the brain following head trauma.
- | Journal: Endothelial Dysfunction in Fabry Disease Is Related to Glycocalyx Degradation. (Pubmed Central) - Feb 17, 2022
We conclude that chronic inflammation, including the release of heparanases, appears to be responsible for the degradation of the endothelial glycocalyx and may explain the endothelial dysfunction in FD. This process is partially reversible by FD-specific and anti-inflammatory treatment, such as targeted protective Tie2 treatment.
- || Review, Journal: Endothelial Dysfunction after Hematopoietic Stem Cell Transplantation: A Review Based on Physiopathology. (Pubmed Central) - Feb 16, 2022
In the second part, we review the abnormalities of these factors found in the ED complications associated with HSCT. In the third part, a review of agents used in the treatment of ED after HSCT is presented.
- | Journal: The angiopoietin-Tie2 pathway regulates Purkinje cell dendritic morphogenesis in a cell-autonomous manner. (Pubmed Central) - Feb 10, 2022
Functionally, mice with deletion of Tie2 in PCs present alterations in PC network functionality. Altogether, our data propose Ang/Tie2 signaling as a mediator of intercellular communication between neural cells, ECs, and PCs, required for proper PC dendritic morphogenesis and function.
- || Clinical, Journal: Circulating lncRNAs HIF1A-AS2 and LINLK-A: Role and Relation to Hypoxia-Inducible Factor-1α in Cerebral Stroke Patients. (Pubmed Central) - Feb 8, 2022
Serum levels of phosphatidylinositol 3-kinase (PI3K), phosphorylated-Akt (p-Akt), vascular endothelial growth factor (VEGF), and angiopoietin-1 (ANG1) as well as their receptors, malondialdehyde (MDA), and total antioxidant capacity (TAC) were significantly increased, whereas brain-derived neurotrophic factor (BDNF) levels were significantly decreased particularly in hemorrhagic stroke versus ischemic groups. Eventually, these findings support the role of lncRNAs HIF1A-AS2 and LINK-A as well as HIF1-α in activation of angiogenesis, neovascularization, and better prognosis of stroke, especially the hemorrhagic type.
- | Preclinical, Journal: Secretome from Human Mesenchymal Stem Cells-Derived Endothelial Cells Promotes Wound Healing in a Type-2 Diabetes Mouse Model. (Pubmed Central) - Feb 5, 2022
Functional analysis demonstrated that a cocktail of these proteins enhanced the wound healing process similar to hMSC-EC secretome in HFD mice. Overall, our results show that hMSC-EC secretome or a combination of specific proteins enriched in the hMSC-EC secretome enhanced wound healing process under hyperglycemic conditions.
- | Biomarker, Journal, IO biomarker: Immune-related gene ANGPT1 is an adverse biomarker for endometrial carcinoma. (Pubmed Central) - Feb 5, 2022
A high-infiltrating regulatory T cell would improve the prognosis for EC patients. The gene ANGPT1 can increase the infiltration of T cells and improve the prognosis of EC patients.
- An Open-label Trial With Plasma Prekallikrein Oligonucleotide Antisense Therapy To Control Angioedema Attacks In Hereditary Angioedema Patients With Normal C1-inhibitor () - Feb 4, 2022 - Abstract #AAAAI2022AAAAI_2081;
The gene ANGPT1 can increase the infiltration of T cells and improve the prognosis of EC patients. Prophylactic treatment with PKK-LRx in patients with nC1-INH-HAE was well tolerated and resulted in significantly improved disease control.
- | Journal: Angiopoietin 1 release from human neutrophils is independent from neutrophil extracellular traps (NETs). (Pubmed Central) - Jan 29, 2022
Prophylactic treatment with PKK-LRx in patients with nC1-INH-HAE was well tolerated and resulted in significantly improved disease control. Our study suggests that severely ill patients with HFpEF and diabetes synthesize and release a greater abundance of NETs while Ang1 exocytosis is independent of NETs synthesis.
- || Clinical, Journal: Mapping Angiopoietin1 expression in the developing and adult brain. (Pubmed Central) - Jan 28, 2022
Our study suggests that severely ill patients with HFpEF and diabetes synthesize and release a greater abundance of NETs while Ang1 exocytosis is independent of NETs synthesis. No abstract available
- | Preclinical, Journal: Local intramuscular administration of ANG1 and VEGF genes using plasmid vectors mobilizes CD34+ cells to peripheral tissues and promotes angiogenesis in an animal model. (Pubmed Central) - Jan 28, 2022
Our study confirmed that therapy with ANG1 plasmid alone or ANG1/VEGF bicistronic construct is safe and effective in a rat model. The therapy resulted in the recruitment of more CD34+ vascular endothelial cells than in the control group receiving naked plasmid.
- | Journal: Angiopoietin-1 enhanced myocyte mitosis, engraftment, and the reparability of hiPSC-CMs for treatment of myocardial infarction. (Pubmed Central) - Jan 27, 2022
The therapy resulted in the recruitment of more CD34+ vascular endothelial cells than in the control group receiving naked plasmid. Transient overexpression of Ang-1 enhanced hiPSC-aCM mitosis and engraftment and increased the reparability potency of hiPSC-aCMs for treatment of MI.
- | Journal: Strontium-calcium phosphate hybrid cement with enhanced osteogenic and angiogenic properties for vascularised bone regeneration. (Pubmed Central) - Jan 27, 2022
Sr-CPHC also exhibited enhancement of neovascularization in subcutaneous connective tissue in a rat subcutaneous implantation model. Thus, the Sr-CPHC with the dual effects of osteogenesis and angiogenesis shows great potential for clinical applications such as the repair of ischemic osteonecrosis and critical-size bone defects.
- | Preclinical, Journal: HPLC/MS Profiling and Healing Activity of a Muco-Adhesive Formula of Salvadora persica against Acetic Acid-Induced Oral Ulcer in Rats. (Pubmed Central) - Jan 27, 2022
This can be attributed, at least partly, to its anti-inflammatory, antioxidant, procollagen and angiogenic activities. These findings provide support and validity for the use of S. persica as a traditional and conventional treatment for oral disorders.
- | Journal: Angiopoietin-1 Mimetic Nanoparticles for Restoring the Function of Endothelial Cells as Potential Therapeutic for Glaucoma. (Pubmed Central) - Jan 26, 2022
NPs with a ligand density of 25% opposed VEGF-induced Ca influx in HUVECs significantly which could possibly increase cell relaxation and thus aqueous humor drainage, whereas the expression and synthesis of eNOS was not significantly altered. Therefore, we suggest Angpt-1 mimetic NPs as a first step towards a causative therapy to recover the loss of SC cell function during glaucoma.
- | Journal: Macrophage-polarizing stimuli differentially modulate the inflammatory profile induced by the secreted phospholipase A group IA in human lung macrophages. (Pubmed Central) - Jan 19, 2022
Moreover, IL-10 inhibited LPS-induced ANGPT2 production. In conclusion, we demonstrated a fine-tuning modulation of svGIA-activated HLMs differentially exerted by the classical macrophage-polarizing cytokines.
- | Journal: An autophagic deficit in the uterine vessel microenvironment provokes hyperpermeability through deregulated VEGFA, NOS1, and CTNNB1. (Pubmed Central) - Jan 14, 2022
We showed that autophagic deficit in the uterine vessel microenvironment provokes hyperpermeability through the deregulation of VEGFA, NOS1, and CTNNB1. ACTA2: actin, alpha 2, smooth muscle, aortic; Amhr2: anti-Mullerian hormone type 2 receptor; ANGPT1: angiopoietin 1; ATG: autophagy-related; CDH5: cadherin 5; CLDN5: claudin 5; COL1A1: collagen, type I, alpha 1; CSPG4/NG2: chondroitin sulfate proteoglycan 4; CTNNB1: catenin (cadherin associated protein), beta 1; DES: desmin; EDN1: endothelin 1; EDNRB: endothelin receptor type B; F3: coagulation factor III; KDR/FLK1/VEGFR2: kinase insert domain protein receptor; LYVE1: lymphatic vessel endothelial hyaluronan receptor 1; MAP1LC3B: microtubule-associated protein 1 light chain 3 beta; MCAM/CD146: melanoma cell adhesion molecule; MYL2: myosin, light polypeptide 2, regulatory, cardiac, slow; MYLK: myosin, light polypeptide kinase; NOS1/nNOS: nitric oxide synthase 1, neuronal; NOS2/iNOS: nitric oxide synthase 2, inducible; NOS3/eNOS: nitric oxide synthase 3, endothelial cell; OVX: ovariectomy; PECAM1/CD31: platelet/endothelial cell adhesion molecule 1; POSTN: periostin, osteoblast specific factor; SQSTM1: sequestosome 1; TEK/Tie2: TEK receptor tyrosine kinase; TJP1/ZO-1: tight junction protein 1; TUBB1, tubulin, beta 1 class VI; USC: uterine stromal cell; VEGFA: vascular endothelial growth factor A; VSMC: vascular smooth muscle cell.
- || Clinical, Journal, Pleural effusion: Diagnostic and Prognostic Utility of the Extracellular Vesicles Subpopulations Present in Pleural Effusion. (Pubmed Central) - Jan 13, 2022
The corresponding ratios of Mesothelin, Galectin-1, Osteopontin, and VEGF were higher in MPM effusions compared to those in the benign group. These findings demonstrate that relevant diagnostic markers can be recovered from exosomes.
- | Journal: Pericyte insulin receptors modulate retinal vascular remodeling and endothelial angiopoietin signaling. (Pubmed Central) - Jan 12, 2022
Hence, insulin signaling in pericytes promotes angiopoietin-1 secretion and endothelial Tie2 signaling and perturbation of this leads to excessive vascular sprouting and venous plexus abnormalities. This phenotype mimics elements of diabetic retinopathy, and future work should evaluate pericyte insulin signaling in this disease.
- ||||| Clinical: This study found that, among patients with AKI, the ratio of 2 markers of blood vessel stability—angiopoietin-1 to angiopoietin-2—may help predict future risk of chronic kidney disease progression, heart failure, and death https://t.co/FmVXzBp4ya @KidneydrChirag @AlpIkizler (Twitter) - Jan 11, 2022
- | Journal: Extracellular signal-regulated kinase 5 regulates the malignant phenotype of cholangiocarcinoma cells. (Pubmed Central) - Jan 11, 2022
This phenotype mimics elements of diabetic retinopathy, and future work should evaluate pericyte insulin signaling in this disease. ERK5 is a key mediator of growth and migration of CCA cells and supports a pro-tumorigenic cross-talk between the tumor and the microenvironment.
- | Journal: Apelin Promotes Endothelial Progenitor Cell Angiogenesis in Rheumatoid Arthritis Disease via the miR-525-5p/Angiopoietin-1 Pathway. (Pubmed Central) - Dec 30, 2021
Importantly, infection with APLN shRNA mitigated EPC angiogenesis, articular swelling, and cartilage erosion in ankle joints of mice with collagen-induced arthritis. APLN is therefore a novel therapeutic target for RA.
- | Journal: Bioactive decellularized cardiac extracellular matrix-based hydrogel as a sustained-release platform for human adipose tissue-derived stromal cell-secreted factors. (Pubmed Central) - Dec 29, 2021
APLN is therefore a novel therapeutic target for RA. The use of dECM hydrogels as a platform to bind and release paracrine factors secreted by (mesenchymal) cells is a potential alternative in the context of cardiovascular regeneration.
- | Journal: Biomimetic Hydrogels Loaded with Nanofibers Mediate Sustained Release of pDNA and Promote In Situ Bone Regeneration. (Pubmed Central) - Dec 22, 2021
The cell experiment shows that this system can significantly promote MC3T3-E1 cell attachment, proliferation, as well as osteogenic-related and angiogenic-related genes expression of MC3T3-E1 cells. Moreover, the in vivo results show that the composite scaffold with activated gene fibers can significantly promote osteogenesis and vascularization leading to favorable capacity of bone regeneration, meaning that the resulting biomimetic composite hydrogel scaffolds are excellent candidates for bone repair materials.
- Remote Ischemic Conditioning With Exercise (RICE) Induced Better Neurorehabilitation After Ischemic Stroke (Hall B2, Poster Hall; Board No. MP65) - Dec 21, 2021 - Abstract #ISC2022ISC_911;
RICE induced a better rehabilitation after ischemic stroke by promoting neuroplasticity. This study established the RICE strategy and provided novel clues to pave future endeavors in stroke rehabilitation.
- | Journal: Inhibition of Notch signaling pathway reduces angiogenesis in hypertrophic scar. (Pubmed Central) - Dec 17, 2021
The expressions of angiogenesis-related factors appeare to be up-regulated during the formation of proliferative scar. When the Notch signaling pathway is inhibited, the up-regulated angiogenic factors show a decreasing trend and the proliferative scar is alleviated, which suggests that Notch signaling pathway may affect the formation of hyperplastic scar by regulating the expression of angiogenic factors.
- | Preclinical, Journal: Effects of Different Target Temperatures on Angiogenesis and Neurogenesis Following Resuscitation in a Porcine Model After Cardiac Arrest. (Pubmed Central) - Dec 17, 2021
When the Notch signaling pathway is inhibited, the up-regulated angiogenic factors show a decreasing trend and the proliferative scar is alleviated, which suggests that Notch signaling pathway may affect the formation of hyperplastic scar by regulating the expression of angiogenic factors. Lower target temperature showed greater protective effects against cerebral injuries after CPR, and the improved neurological outcomes after TTM may be associated with decreased expression of pro-inflammatory cytokines and increased expression of blood-brain barrier and neurogenesis regulatory factors in this porcine model of CA following resuscitation.
- | Preclinical, Journal: Treatment with an Angiopoietin-1 mimetic peptide promotes neurological recovery after stroke in diabetic rats. (Pubmed Central) - Dec 16, 2021
Lower target temperature showed greater protective effects against cerebral injuries after CPR, and the improved neurological outcomes after TTM may be associated with decreased expression of pro-inflammatory cytokines and increased expression of blood-brain barrier and neurogenesis regulatory factors in this porcine model of CA following resuscitation. Delayed VT treatment (24 h after stroke) significantly improves neurological function, promotes vascular and white matter remodeling, and decreases inflammation in the ischemic brain after stroke in T1DM rats.
- | Preclinical, Journal: Heightened activation of embryonic megakaryocytes causes aneurysms in the developing brain of mice lacking podoplanin. (Pubmed Central) - Dec 16, 2021
Blocking platelet activation prevented the PDPN-deficient embryo from developing vascular defects. Our data reveal a new role for PDPN in regulating eMk function during midgestation.
- Observational data, Journal: Serum Angiopoietin-1 and -2 and VEGF are associated with severe disease in vivax malaria. (Pubmed Central) - Dec 16, 2021
Our data reveal a new role for PDPN in regulating eMk function during midgestation. We conclude that Ang-1, Ang-2 and VEGF are markers of disease severity in vivax malaria.
- | Journal: Regulatory role of TIGAR on endothelial metabolism and angiogenesis. (Pubmed Central) - Dec 16, 2021
In addition, knockout of TIGAR blunted TAC-induced cardiac hypertrophy and dysfunction seen in the WT mice. In conclusion, knockout of TIGAR improves endothelial angiogenetic capabilities by enhancing the endothelial glycolytic function, mitochondrial respiration, and proangiogenic signaling, which leads to increased coronary capillary density and vascular function and protects against chronic stress.
- | Journal: Overexpression of COMP-Angiopoietin-1 in K14-Expressing Cells Impairs Hematopoiesis and Disturbs Erythrocyte Maturation. (Pubmed Central) - Dec 16, 2021
COMP-Ang1 protein did not alter the frequency or GATA-1 expression of erythroblasts in recipient mice or in cultured BM cells. Together, our findings suggest that excessive COMP-Ang1 impairs the functions of BM HSCs and MSCs and hematopoietic processes, eventually leading to abnormal erythropoiesis via imbalanced SDF-1/CXCR4 axis and GATA-1 expression rather than Ang1/Tie2 signaling axis alterations.
- | Journal: CD44 Sorted Cells Have an Augmented Potential for Proliferation, Epithelial-Mesenchymal Transition, Stemness, and a Predominantly Inflammatory Cytokine and Angiogenic Secretome. (Pubmed Central) - Dec 16, 2021
The CD44+ CSCs cells demonstrated significant increased levels of EMT-related genes TWIST1 and CDH2 (N-cadherin), CSC-related genes CD44 and CD133 (PROM1), stemness-related genes OCT4, SOX2, inflammatory cytokines IL-1ß, IL-12, IL-18 and TNF-α and angiogenic factors Angiopoietin-1, Angiopoietin-2, bFGF and VEGF while levels of epithelial gene CDH1 (E-cadherin) decreased in comparison to mixed cell population. The genetic and secretome profiling of the CD44+ CSCs could serve as diagnostic and prognostic tools in the treatment of oral cancers.
- || Clinical, Journal: Diagnostic and prognostic significance of serum angiopoietin-1 and -2 concentrations in patients with pulmonary hypertension. (Pubmed Central) - Dec 16, 2021
Higher ANGP-2 concentration was a significant worse prognostic factor (hazard ratio = 6.063, p = 0.037), while serum ANGP-1 concentration was not. In conclusion, serum ANGP-2 may be a useful diagnostic and prognostic biomarker in patients with PH, especially in patients with group 3 PH.
- || Review, Journal: Update Overview of the Role of Angiopoietins in Lung Cancer. (Pubmed Central) - Dec 6, 2021
The present review focuses on the clinical impact of the Angiopoietin-1, Angiopoietin-2, and Angiopoietin-4 levels in patients diagnosed with NSCLC, emphasizing the interaction between them, and how they affect the development, progression, and metastasis of lung disease. Finally, it estimates the role of angiopoietins levels in the effective therapy of lung cancer patients.
- | Journal: New Soluble Angiopoietin Analog of Hepta-ANG1 Prevents Pathological Vascular Leakage. (Pubmed Central) - Nov 29, 2021
The new Hepta-ANG1 fusion is easy to produce and displays remarkable stability with high multimericity that can potently activate Tie2. It could be a new candidate ANG1 mimetic therapy for treatments of inflammatory vascular leak, such as acute respiratory distress syndrome and sepsis.
- || Biomarker, Review, Journal, Tumor microenvironment: Targeting Tie2 in the Tumor Microenvironment: From Angiogenesis to Dissemination. (Pubmed Central) - Nov 29, 2021
Therefore, Ang-Tie2 signaling functions as an angiogenic switch during tumor progression and metastasis. Here we review the recent advances and complexities of targeting Tie2 signaling in the tumor microenvironment as a possible anti-angiogenic, and anti-metastatic, therapy and describe its use in combination with chemotherapy.
- | Journal: An engineered tetra-valent antibody fully activates the Tie2 receptor with comparable potency to its natural ligand angiopoietin-1. (Pubmed Central) - Nov 25, 2021
Additionally, single administration of ASP4021 significantly suppressed mustard-oil-induced vascular permeability in rats. ASP4021 may thus be a potential therapeutic candidate for diseases associated with vascular weakness such as diabetic retinopathy, diabetic macular edema and critical limb ischemia.
- | Preclinical, Journal: Combined treatment with C16 peptide and angiopoietin-1 confers neuroprotection and reduces inflammation in 3-nitropropionic acid-induced dystonia mice. (Pubmed Central) - Nov 25, 2021
We found that C16+Ang-1 treatment alleviated 3-NP-induced behavioral, biochemical, and cellular alterations in the central nervous system and promoted function recovery by restoring vascular permeability and reducing inflammation in the micro-environment. In conclusion, our results confirmed the neuroprotective effect of combined C16+Ang-1 treatment and suggest their potential as a complementary therapeutic against 3-NP-induced dystonia.
- AV-GBM-1 / AiVita Biomedical
PHASE II TRIAL OF VACCINE IMMUNOTHERAPY IN PRIMARY GLIOBLASTOMA: ADJUNCTIVE AUTOLOGOUS DENDRITIC CELLS PULSED WITH LYSATE FROM IRRADIATED SELF-RENEWING AUTOLOGOUS TUMOR CELLS (AV-GBM-1) () - Nov 16, 2021 - Abstract #SNO2021SNO_1215;
P2
A phase III trial is in development. Clinicaltrials.gov NCT03400917.
- Avastin (bevacizumab) / Roche
Immunohistological analysis of angiogenic factors other than VEGF in glioblastomas in relation to the use of bevacizumab (Exhibit Hall D) - Nov 16, 2021 - Abstract #SNO2021SNO_887;
Angiopoietin1, angiopoietin2 and ephrinA2 were characteristically expressed in the microvessels less than 15μm. The increased expression of PlGF might be associated with the recurrence after bevacizumab.
- || Clinical, Journal: Exercise Training Enhances Angiogenesis-Related Gene Responses in Skeletal Muscle of Patients with Chronic Heart Failure. (Pubmed Central) - Nov 16, 2021
Changes in capillary-to-fibre ratio were found to be strongly associated with Tie2 and HIF-1α expression. This was the first study demonstrating that both HIIT and combined HIIT with strength training enhanced similarly the expression profile of angiogenic factors in skeletal muscle of HF patients, possibly driving the angiogenic program in the trained muscles, although those gene expression increases were found to be only partially related with muscle capillarization.
- || Clinical, Review, Journal: The Critical Role of Growth Factors in Gastric Ulcer Healing: The Cellular and Molecular Mechanisms and Potential Clinical Implications. (Pubmed Central) - Nov 16, 2021
Local therapy with cDNA of human recombinant VEGF165 in combination with angiopoietin1, or with the NGF protein, dramatically accelerates GU healing and improves the quality of mucosal restoration within ulcer scars. The future directions for accelerating and improving healing include local gene and protein therapies with growth factors, their combinations, and the use of stem cells and tissue engineering.
- | thalidomide / Generic mfg.
Journal: Thalidomide Inhibits Angiogenesis via Downregulation of VEGF and Angiopoietin-2 in Crohn's Disease. (Pubmed Central) - Nov 11, 2021
Therefore, our study suggests that VEGF and Ang-2 levels are up-regulated in pediatric CD patients. It also indicated that thalidomide can be able to deactivate endothelium by the downregulation effect on angiogenic factors by targeting VEGF and Ang-2.
- | Avastin (bevacizumab) / Roche
Journal: Interleukin-6 as an enhancer of anti-angiogenic therapy for ovarian clear cell carcinoma. (Pubmed Central) - Nov 11, 2021
Although bevacizumab (Bev) is a widely used anti-angiogenic agent for EOC, the efficacy of Bev and the role of IL-6 in modulating angiogenesis in OCCC are unknown. We performed tube formation assays using human umbilical vein endothelial cells (HUVEC) cultured in OCCC cell-conditioned medium and using cells directly co-cultured with OCCC cells...Finally, depletion of Ang1 abrogated the effects of IL-6 inhibition on Bev activity, demonstrating that IL-6 supports the anti-angiogenic activity of Bev by suppressing Ang1 expression and promoting dependence on VEGF for angiogenesis. Altogether, our data suggest that OCCC tumors with high IL-6 levels are candidates for Bev therapy.
- | Journal: Long Non-coding RNA Rhabdomyosarcoma 2-Associated Transcript Regulates Angiogenesis in Endothelial Cells. (Pubmed Central) - Nov 10, 2021
We conclude that RMST is expressed in human ECs and that this expression is upregulated in response to hypoxia and during differentiation into capillary-like structures. We also conclude that RMST plays important roles in EC survival and migration.
- | Journal: Angiopoietins stimulate pancreatic islet development from stem cells. (Pubmed Central) - Nov 10, 2021
We also discovered the formation of endothelium within the islets under Ang2 stimulation. These results strongly suggest that angiopoietin acts as a signaling molecule to endorse in vitro islet development from iPSCs.
- | Preclinical, Journal: Neutralizing antibody to proNGF rescues erectile function by regulating the expression of neurotrophic and angiogenic factors in a mouse model of cavernous nerve injury. (Pubmed Central) - Nov 4, 2021
These results strongly suggest that angiopoietin acts as a signaling molecule to endorse in vitro islet development from iPSCs. The preservation of damaged cavernous neurovasculature through inhibition of the proNGF/p75 pathway may be a novel strategy to treat radical prostatectomy-induced erectile dysfunction.
- | Journal: Associations of angiopoietins with heart failure incidence and severity. (Pubmed Central) - Nov 4, 2021
Ang2 was associated with incident heart failure or death among adults without cardiovascular disease at baseline and with disease severity in individuals with existing heart failure. Our findings that Ang2 is elevated prior to disease onset and that elevations reflect disease severity, suggest Ang2 may contribute to heart failure pathogenesis.
- | Biomarker, Journal: Angiopoietin-1: an early biomarker of diabetic nephropathy? (Pubmed Central) - Nov 4, 2021
Our findings that Ang2 is elevated prior to disease onset and that elevations reflect disease severity, suggest Ang2 may contribute to heart failure pathogenesis. No abstract available