- |||||||||| Journal: Bone Density in Transgender Youth on Gender-Affirming Hormone Therapy. (Pubmed Central) - Apr 2, 2024
BMD Z-score was negatively correlated with GnRHa duration (male norms: r = -0.5, P = .005; female norms: r = -0.4, P = .029) and positively correlated with BMI (male norms: r = 0.4, P = .003; female norms: r = 0.4, P = .004). In this cross-sectional cohort, total body BMD Z-scores were slightly below average, but lowest in the AMAB group on GnRHa monotherapy.
- |||||||||| Journal: In Silico Evaluation of the Binding Energies of Androgen Receptor Agonists in Wild-Type and Mutational Models. (Pubmed Central) - Jun 9, 2023
Our results also show the differences and equivalences between the different agonists, in addition to evaluating the difference between the DHT ligand in complex with the wild-type and mutant receptor, presenting the main amino acid residues that involve the interaction with the ligands. The computational methodology used proves to be an operative and sophisticated choice to help in the search for pharmacological agents for various therapies that have androgen as a target.
- |||||||||| goserelin acetate / Generic mfg.
Journal: Sex Hormone Suppression and Physical Activity: Possible Implications for Transgender Individuals. (Pubmed Central) - Jan 17, 2023
Female and male rats received 4 weeks of sex hormone suppression using the GnRHa goserelin acetate (GA) or received a placebo as a control (CON)...Reduced sex hormone availability reduced wheel running activity in female and male rats. Understanding the role that sex hormone manipulation has on physical activity may be an important consideration in promoting physical activity in transgender individuals receiving treatments that reduce sex hormone availability.
- |||||||||| Eligard (leuprolide acetate) / Tolmar, Sanofi, Recordati
Journal: Advanced delivery of leuprorelin acetate for the treatment of prostatic cancer. (Pubmed Central) - Jul 6, 2022
The development of second-generation leuprorelin acetate (LA) depot formulation (Eligard®, Recordati S.p.A) allowed a consistent and controlled release of leuprorelin between injections and a more efficient reduction of testosterone levels with respect to conventional LHRH agonists...Results of the registration studies and post-marketing clinical trials demonstrate that the LA gel depot provides long-term efficacy in the clinical practice and a good degree of tolerability. Overall, collected data suggest that the LA gel depot can represent the ADT reference therapy in advanced PCa.
- |||||||||| Preclinical, Journal: Phytochemical analysis, in silico study and toxicity profile of Cycas pectinata Buch.-Ham fruit in mice. (Pubmed Central) - Feb 5, 2022
Thus, it can be suggested that CPFE at a dose of 100 and 300 mg/kg would be safe for consumption. The phytochemicals analysis by LC-MS, NMR and FTIR showed the presence of 32 major chemical compounds with certain biological activity like anti-neoplastic, antioxidant, and possible modulator of steroid metabolism (cholesterol antagonist and agonist of testosterone 17β-dehydrogenase) as predicted by PASS analysis.
- |||||||||| Journal: Osteocalcin: A Protein Hormone Connecting Metabolism, Bone and Testis Function. (Pubmed Central) - Feb 5, 2021
In this review, experimental data supporting the inter-organ communication roles of this protein are discussed, together with the available data supporting the consistency between experimental data obtained in animals and those reported in humans. In addition, a specific session has been devoted to the possible significance the OCN as a template agonist on its receptor GPRC6A, for the development of novel therapeutic and pharmacological approaches for the treatment of dismetabolic states and male infertility.
- |||||||||| nilutamide / Generic mfg.
Journal: Stromal-AR influences the growth of epithelial cells in the development of benign prostate hyperplasia. (Pubmed Central) - Feb 3, 2021
The secretome (conditioned media-CM) was collected from AR agonist (testosterone-propionate-TP) and antagonist (Nilutamide-Nil) treated BPH patient-derived stromal cells and exposed to BPH epithelial cells...Hence, the present study highlighted the restricted disease progression and retains the basal/progenitor state of BPH epithelial cells through the activation of stromal-AR. On the contrary, AR-independent aggressive BPH epithelial cell growth due to paracrine action of loss stromal-AR directs us to reform AR pertaining treatment regimes for better clinical outcomes.
- |||||||||| bicalutamide / Generic mfg.
Journal: Structural Dynamics of Agonist and Antagonist Binding to the Androgen Receptor. (Pubmed Central) - Aug 13, 2020
Antiandrogens, such as the pharmaceuticals bicalutamide and hydroxyflutamide, act as agonists in the absence of androgens and as antagonists in their presence or in high concentration...A new site was also identified as a potential surface for allosteric binding. These results shed light on the effect of agonists and antagonists on the structure and dynamics of AR.
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