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- ELD607 / Eldec Pharma
Eld607 Attenuates Pulmonary Fibrosis By Suppressing Orai1-mediated Ca (W414AB (Level IV, OCCC West Concourse); Poster Board # 913) - Mar 3, 2026 - Abstract #ATS2026ATS_8083;
Our data indicate a hitherto unrecognized role for Orai1/Ca2+ signaling in the initiation of fibrosis. Further, our data suggest that inhibition of Orai1 with inhaled ELD607 may be a novel therapeutic approach to reverse fibrosis in IPF patients.
- The Transcriptome of CD14+CD163-HLA-DRlow Monocytes Predicts Mortality in Idiopathic Pulmonary Fibrosis and Suggests Potential Therapeutic Targets (W230 (Level II, OCCC West Concourse); Poster Board # 402) - Mar 3, 2026 - Abstract #ATS2026ATS_7953;
The transcriptome of CD14+CD163-HLA-DRlow monocytes is associated with increased mortality in patients with IPF. Its reversal should be investigated as a precision-based-therapy in IPF.
- rentosertib (INS018_055) / Insilico Medicine
TNIK Mediates Mesenchymal Transition of Pleural Mesothelial Cells (Area K, Halls WA2-WA3 (Level II, OCCC West Concourse); Poster Board # P1886) - Mar 3, 2026 - Abstract #ATS2026ATS_6414;
A novel small molecule inhibitor of Traf2- and Nck-interacting kinase (TNIK), INS018_055, identified through generative AI methods, has recently advanced to clinical trials in patients with idiopathic pulmonary fibrosis (IPF), yielding encouraging initial results...These studies suggest that targeting TNIK may potentially reverse established MesoMT in vivo. CONCLUSIONS : The findings from this study suggest that TNIK plays an essential role in regulating MesoMT and may serve as a novel target for PF.
- treprostinil / Generic mfg.
g?12 Is Involved in Tgf-?-Induced Extracellular Matrix Production by Human Lung Fibroblasts (Area K, Halls WA2-WA3 (Level II, OCCC West Concourse); Poster Board # P1881) - Mar 3, 2026 - Abstract #ATS2026ATS_6409;
Elucidating the interplay between GPCR signaling, particularly the G?12 subunit, and TGF-? may identify novel therapeutic strategies for IPF.
- bleomycin / Generic mfg.
Novel Synthetic Biology Tools for Studying and Treating Lung Disease (West F4 (Level II, OCCC West Concourse)) - Mar 3, 2026 - Abstract #ATS2026ATS_3225;
We can target the lung (RAGE SynNotch) and specific regions of fibrosis in the lung (TNC-D CAR) using novel synthetic biology tools. These tools will enable delivery of signaling pathway modulators like TGF-b inhibitors specifically to areas of lung fibrosis in vivo and represent the first steps towards mechanism-specific cell-based therapies for IPF.
- Uncovering Molecular Mechanisms and Therapeutic Modulators of TGF-?/BMP Pathways for Resolution of Pulmonary Arterial Hypertension (Area K, Halls WA2-WA3 (Level II, OCCC West Concourse); Poster Board # P1832) - Mar 3, 2026 - Abstract #ATS2026ATS_2344;
and BMP signalling thereby restoring cellular defects such as excessive proliferation and reduction of apoptosis. Taken together, this study identifies promising therapeutic agents, clarifies the underlying molecular mechanisms and uncovers novel additional targets, which may be explored for developing novel diagnostics and therapeutics
- | Tagrisso (osimertinib) / AstraZeneca, vactosertib (TEW-7197) / National OncoVenture, Theragen Etex, nintedanib / Generic mfg.
Journal, IO biomarker: TGF-? Inhibitor Potentiates Osimertinib-Induced Anti-Tumor Immunity in Egfr-Mutant Lung Cancer. (Pubmed Central) - Feb 27, 2026
inhibitors potentiates osimertinib-induced antitumor immunity. These findings highlight a novel therapeutic strategy for EGFR-mutated NSCLC and warrant further clinical investigation.
- | bleomycin / Generic mfg.
Journal: Yizong Tongluo formula attenuates idiopathic pulmonary fibrosis and inflammatory injury by inhibiting HIF-1?/LSH/SCD1-mediated ferroptosis. (Pubmed Central) - Feb 27, 2026
Molecular and histological analyzes were performed using TGF-?-treated MRC-5 fibroblast cells and a bleomycin-induced rat model of pulmonary fibrosis...These findings indicate that YZTLF mitigates IPF progression in the context of Qi deficiency and blood stasis by suppressing ferroptosis-driven inflammation and remodeling the hypoxic microenvironment via the HIF-1?/LSH/SCD1 pathway. This provides a mechanism-based rationale for its use in this TCM-defined IPF subtype.
- | losartan / Generic mfg.
Clinical, Review, Journal: Topical Losartan in Ophthalmology: Rationale, Experimental and Clinical Evidence, and Emerging Clinical Applications. (Pubmed Central) - Feb 27, 2026
This review summarizes the biological rationale for the use of topical losartan in ophthalmology, including its molecular mechanisms of action, pharmacologic considerations, and safety profile. We critically review preclinical studies in corneal models, as well as emerging clinical applications.
- | Journal: Human Lung Allografts Experience Persistent Fibrogenic Shift Following Acute Cellular Rejection. (Pubmed Central) - Feb 26, 2026
and mTOR pathway activation following histologic ACR resolution provides molecular insight into ACR-CLAD linkage and suggests mTOR inhibition and TGF-? blockade as potential therapeutic mechanisms to prevent CLAD.
- | Journal: Emergence of a Central Nervous System: A Two-Step Evolutionary Model Suggested by Sea Urchin Experiments. (Pubmed Central) - Feb 25, 2026
These findings strongly support the "neural default model" and underscore the importance of combining Wntbased anterior patterning with TGF?-signaling-mediated neural restriction in CNS centralization. Although the idea is not entirely new, the data from sea urchins provide rare experimental evidence for how ancient axial patterning systems could have cooperatively shaped the emergence of a centralized nervous system in early bilaterians.
- | Journal: Extracellular Vesicle Cargo from Lipofibroblasts Mitigates COPD by Alveolar Type II Cell Restoration. (Pubmed Central) - Feb 25, 2026
Although the idea is not entirely new, the data from sea urchins provide rare experimental evidence for how ancient axial patterning systems could have cooperatively shaped the emergence of a centralized nervous system in early bilaterians. Our findings highlight the therapeutic potential of LipoFB-EVs as a novel regenerative therapy for COPD, offering promising avenues for future clinical interventions.
- Placental Signaling Factors Linking Early-Onset Preeclampsia to Risk of Necrotizing Enterocolitis in a High-Risk Preterm Patient Population (Poster Hall) - Feb 25, 2026 - Abstract #PAS2026PAS_2645;
Our findings highlight the therapeutic potential of LipoFB-EVs as a novel regenerative therapy for COPD, offering promising avenues for future clinical interventions. Preterm infants from PE pregnancies had a significantly higher risk of NEC compared with those from PTL pregnancies (OR 3.7, 95% CI 1.34
- | Journal: Acting on dormancy: the interplay between the actin cytoskeleton and tumor cell dormancy. (Pubmed Central) - Feb 24, 2026
The inhibition of TGF-B or gelsolin prevents the change in cell morphology, and the cells remain stiff and become susceptible to immune clearance in vivo. This study identifies a novel vulnerability of dormant tumor cells that could be exploited to eliminate dormant DTCs and prevent metastatic relapse.
- | Journal: 2-Hydroxyestradiol Regulates Extracellular Matrix Deposition Through Estrogen Receptor Beta Activation in Airway Smooth Muscle Cells. (Pubmed Central) - Feb 23, 2026
Furthermore, 2-HE significantly decreased the TGF-?-induced transcriptional activities of AP-1 and NF-?B. Overall, our findings suggest 2-HE blunts TGF-?-induced ECM through ER?; therefore, it may serve as a novel therapeutic target for airway remodeling and asthma.
- | Journal: MAGL-18c attenuates LPS-induced sepsis-associated liver injury by inhibiting TGF-?/Smad signaling and remodeling medium- and long-chain fatty acid metabolism. (Pubmed Central) - Feb 23, 2026
Moreover, MAGL-18c significantly improved liver histopathology, reduced neutrophil infiltration, modulated unsaturated fatty acid metabolism, and alleviated hepatocyte apoptosis and mitochondrial dysfunction. These findings indicate that MAGL-18c protects against LPS-induced SALI through coordinated regulation of inflammation, apoptosis, mitochondrial function, and lipid metabolism, highlighting its potential as a promising therapeutic candidate for sepsis-associated liver injury.
- | Journal: Mesenchymal Stem Cells Polarize Macrophages to an Anti-Inflammatory Phenotype to Ameliorate Diabetic Nephropathy. (Pubmed Central) - Feb 23, 2026
(TGF-?) in glomerular mesangial cells. Our study proposes and discusses a mechanism by which MSCs promote the polarization of macrophages from M1 into M2 in the kidney, thereby ameliorating DN.
- | Journal, IO biomarker: The novel MyD88 inhibitor A5S ameliorates inflammation-driven diabetic cardiorenal complications. (Pubmed Central) - Feb 19, 2026
Furthermore, cell-cell crosstalk assays demonstrated that A5S prevented macrophage-induced renal mesangial cell fibrosis and cardiomyocyte hypertrophy. These findings validated the protective effects of A5S against inflammation-driven diabetic cardiorenal complications and highlighted its potential as a drug candidate for targeting MyD88 in anti-inflammatory therapy.
- | bleomycin / Generic mfg.
Journal: RIPK3 Orchestrates Scar-Associated Macrophage Dysfunction to Drive Pulmonary Fibrosis. (Pubmed Central) - Feb 19, 2026
Subsequently, macrophage-specific RIPK3 knockout mice were established, which demonstrated resistance to bleomycin-induced fibrosis...The translational potential of this finding was validated, as lung-specific Ripk3 knockdown also attenuated lung fibrosis. Our findings extend RIPK3 biology beyond its classical role in cell death, highlighting RIPK3 as a key metabolic regulator of the fibrotic niche and suggesting that targeting this immunometabolic axis represents a promising therapeutic strategy for IPF.
- | Journal: Intermittent fasting inhibits Tp53-driven glioma through gut microbiota-mediated methionine-m6A regulation. (Pubmed Central) - Feb 18, 2026
signaling pathway, resulting in suppressing GBM progression. This study proposes a genotype-based hypothesis for the therapeutic effects of IF on tumors, and elucidates the potential RNA modification-related molecular mechanisms underlying the effective suppression of GBM by IF.
- | Journal: ECM1 protects against liver steatosis through PCBP1-mediated iron homeostasis. (Pubmed Central) - Feb 18, 2026
Our study reveals that ECM1 is a critical regulator in MASH, modulating lipid peroxidation by maintaining PCBP1-mediated intracellular iron homeostasis. Targeting ECM1 to restore PCBP1-dependent iron homeostasis may offer a novel therapeutic avenue for MASH.
- | Review, Journal: Molecular mechanisms of skeletal muscle fibrosis and potential targeted therapeutic strategies. (Pubmed Central) - Feb 16, 2026
However, current research still faces challenges such as disease heterogeneity, optimal treatment timing, drug delivery issues, and long-term safety concerns. Therefore, future studies should focus on developing highly specific targeted therapies, integrating multi-omics technologies and imaging assessments, and advancing personalized combination strategies to ultimately achieve effective prevention and treatment of skeletal muscle fibrosis.
- | 5-fluorouracil / Generic mfg.
Biomarker, Journal: ICAM2 loss drives 5-fluorouracil resistance via TGF-?/Smad/SP1/PTN-dependent apoptosis evasion and macrophage remodeling in gastric cancer. (Pubmed Central) - Feb 16, 2026
Therefore, future studies should focus on developing highly specific targeted therapies, integrating multi-omics technologies and imaging assessments, and advancing personalized combination strategies to ultimately achieve effective prevention and treatment of skeletal muscle fibrosis. Our study highlights the clinical impact of ICAM2 downregulation predicting poor outcome and NACT response in AGC patients, and reveals a novel ICAM2/TGF-?/Smad/SP1/PTN signaling mediating 5-FU resistance in GC.
- | Journal: IFN-? and TNF-? Impair Lung Development by Upregulating SMAD7 to Inhibit TGF-? Signaling Pathway and ECM Dysregulation. (Pubmed Central) - Feb 15, 2026
These data delineate a novel inflammatory axis impairing lung development, highlighting SMAD7 and TGF-? pathways as promising intervention targets.
- | Journal: Amygdalin inhibits 17?-estradiol-induced mesenchymal transition through TGF- ?/Smad signaling in normal and endometriotic endometrial epithelial cells. (Pubmed Central) - Feb 14, 2026
signaling. Its efficacy in patient?derived cells further supports its potential as a therapeutic agent for endometriosis.
- | Journal: Triphenyl phosphate accelerates collagen-rich ECM remodeling and proliferation in gastric cancer via partially TGF?/NOTCH-dependent transcription Programs. (Pubmed Central) - Feb 12, 2026
In xenograft models, TPP accelerated tumor growth. Collectively, these data position TPP as an environmental accelerator of ECM-mechanics-proliferation circuitry in GC and highlight druggable nodes of therapeutic and regulatory relevance.
- | nintedanib / Generic mfg.
Journal: Modeling cell-cell interactions to advance drug discovery in Idiopathic Pulmonary Fibrosis. (Pubmed Central) - Feb 12, 2026
inhibitor, SB431542, demonstrated dose-dependent efficacy in the model, with IC50 values comparable to those observed in the clinic, and significantly reduced secretion of fibrosis-related factors. Overall, this study shows that the three-dimensional cell co-culture organoid effectively models progressive lung fibrosis, facilitating the investigation of epithelial-mesenchymal interactions and serving as a patient-relevant model to better predict the efficacy of therapeutics in the clinic.
- | bleomycin / Generic mfg., nintedanib / Generic mfg.
Preclinical, Journal: GTX-11 attenuates lung fibrosis, inflammation and vascular remodeling in preclinical models of lung fibrotic disease. (Pubmed Central) - Feb 12, 2026
The GTX-11m anti-fibrotic and anti-inflammatory effects were comparable or better than nintedanib. Altogether, our studies reveal that GTX-11 is an effective antifibrotic both in vivo and in vitro, suggesting that GTX-11 has potential as a therapeutic option for fibrotic ILDs.
- | Journal: Bidirectional fibrogenic cross-talk revealed in a human iPSC-derived epithelial-mesenchymal co-culture model of pulmonary fibrosis. (Pubmed Central) - Feb 9, 2026
or integrins ?V?1/?V?6 attenuates both fibrotic mesenchymal activation and the presence of ABI cells in iLM/iAT2 co-cultures. Thus, we have established a human iPSC-derived co-culture system that recapitulates key molecular hallmarks of bidirectional fibrogenic epithelial-mesenchymal crosstalk in pulmonary fibrosis, and enables the identification and study of potentially druggable pathways involved in disease initiation and progression.
- | Journal: SOX8 mediates the crosstalk between KRAS and TGF-? pathways to promote the malignant progression of pancreatic cancer. (Pubmed Central) - Feb 9, 2026
This novel KRAS-SOX8-TGF-? axis plays the important role in invasion and metastasis of pancreatic cancer, suggesting SOX8 as a useful prognostic biomarker and therapeutic target.
- | Biomarker, Review, Journal, IO biomarker: Tumor microenvironment-driven drug resistance in urologic cancers: mechanisms and therapeutic targets. (Pubmed Central) - Feb 9, 2026
Novel approaches such as single-cell and spatial transcriptomics, organoid co-culture systems, and TME-derived biomarkers offer new opportunities for patient stratification and therapeutic development. Integrating TME biology into clinical practice is essential to overcome resistance and improve outcomes in urologic oncology.
- | Journal: Mind the GARP: How Glucocorticoids Unleash T Cells against Melanoma. (Pubmed Central) - Feb 6, 2026
This mechanistic insight significantly advances our understanding of how GR shapes tumor immunity and highlights new avenues for overcoming immune checkpoint blockade resistance in melanoma and other cancers. See related article by Earnshaw et al., p. 345.
- SD 208 / J&J, MLN8054 / Takeda
PRIMARY CILIA SHORTENING OF SYSTEMIC SCLEROSIS DERMAL FIBROBLASTS CAN BE MODULATED BY AURORA A KINASE ACTIVITY TO REDUCE FIBROTIC PHENOTYPE (Poster Area 2 at level 1, balcony) - Feb 5, 2026 - Abstract #SSWC2026SSWC_611;
activation can rapidly and reversibly shorten PC length, as previously reported, by a pathway partially dependent on ROCK2. Moreover, we demonstrated that inhibition of the AURKA-HDAC6 axis was able to increase PC length in SSc and shCAV1 fibroblasts to HC levels and reduced their contractile capacity.
- Jardiance (empagliflozin) / Eli Lilly, Boehringer Ingelheim
THE EFFECT OF EMPAGLIFLOZIN ON SKIN FIBROSIS IN A BLEOMYCIN-INDUCED SCLERODERMA MODEL AND COMPARISON OF DIFFERENT ROUTES OF ADMINISTRATION (Poster Area 2 at level 1, balcony) - Feb 5, 2026 - Abstract #SSWC2026SSWC_457;
Moreover, we demonstrated that inhibition of the AURKA-HDAC6 axis was able to increase PC length in SSc and shCAV1 fibroblasts to HC levels and reduced their contractile capacity. In a bleomycin-induced scleroderma model, EMPA reduced skin thickness, inflammatory infiltration, and collagen deposition regardless of administration route.These findings suggest that EMPA exerts antifibrotic and anti-inflammatory effects and may represent a potential therapeutic option for systemic sclerosis.
- SD 208 / J&J, MLN8054 / Takeda
PRIMARY CILIA SHORTENING OF SYSTEMIC SCLEROSIS DERMAL FIBROBLASTS CAN BE MODULATED BY AURORA A KINASE ACTIVITY TO REDUCE FIBROTIC PHENOTYPE (Poster Area 1 at level 0) - Feb 5, 2026 - Abstract #SSWC2026SSWC_235;
activation can rapidly and reversibly shorten PC length, as previously reported, by a pathway partially dependent on ROCK2. Moreover, we demonstrated that inhibition of the AURKA-HDAC6 axis was able to increase PC length in SSc and shCAV1 fibroblasts to HC levels and reduced their contractile capacity.
- | Journal: Bridging acute-chronic myocardial infarction treatment: Dual-regulating of ROS/fibrosis via microenvironment-responsive release of NO and curcumin. (Pubmed Central) - Feb 2, 2026
Moreover, we demonstrated that inhibition of the AURKA-HDAC6 axis was able to increase PC length in SSc and shCAV1 fibroblasts to HC levels and reduced their contractile capacity. This value approached the normal range of 81
- | bleomycin / Generic mfg., pirfenidone / Generic mfg.
Journal: Pterostilbene ameliorates pulmonary fibrogenesis and inflammation targeting IL-23/ATP6V0D2 pathway: remodel local microenvironment of alveolar epithelial cells and fibroblasts. (Pubmed Central) - Jan 30, 2026
Mice were received intratracheal instillation of bleomycin (BLM) and administered PTE or PFD...PTE also inhibited fibrogenesis, EMT, and inflammation in activated-primary LFs and blocked CM-triggered primary LFs activation by regulating IL-23-ATP6V0D2 axis. In conclusion, PTE ameliorated pulmonary fibrosis targeting IL-23/ATP6V0D2 pathway, especially remodeling the local microenvironment of alveolar epithelial cells and fibroblasts, which might be a novel therapeutic strategy against pulmonary fibrosis.
- | Reblozyl (luspatercept-aamt) / BMS, Merck (MSD)
Journal: UBE2O AS A KEY REGULATOR OF DRUG-INDUCED ERYTHROPOIESIS IN THE CONTEXT OF MYELODYSPLASTIC SYNDROMES. (Pubmed Central) - Jan 30, 2026
inhibitors, such as luspatercept, which is approved for the treatment of anemia associated with MDS or ?-thalassemia...Our findings demonstrate that GATA1 binds to the UBE2O promoter, thereby regulating UBE2O transcription and expression. Although further studies are needed to explore the implications of UBE2O in MDS treatment, our work provides potential strategies for novel therapeutic approaches in MDS.
- | Journal: Targeted degradation of MK2 is insufficient to block inflammatory cytokine production in human cells due to cooperativity with MK3 and MK5. (Pubmed Central) - Jan 30, 2026
production regardless of stimulus. The combined data suggest cooperativity between MK2 and either MK3 or MK5 for efficient, cell context-dependent modulation of inflammatory responses.
- | Review, Journal: The emerging role of decorin in pancreatic islet biology: From development to degeneration. (Pubmed Central) - Jan 29, 2026
Within the pancreatic islet microenvironment, decorin influences pancreatic islet morphogenesis and beta-cell differentiation through modulation of local matrix composition and growth factor bioavailability, while conferring protection against diabetic complications through anti-fibrotic properties that mitigate peri-islet extracellular matrix remodeling observed in progressive islet dysfunction. By synthesizing findings from developmental biology, matrix biochemistry, and diabetes research, we address this critical knowledge gap and position decorin as an underrecognized regulator of pancreatic islet biology whose multifaceted mechanisms warrant investigation to reveal therapeutic strategies for preserving beta-cell function and preventing diabetes-associated fibrotic pathology.
- | losartan / Generic mfg.
Journal: 7-Ketolithocholic Acid Exerts Anti-Renal Fibrotic Effects Through FXR-Mediated Inhibition of TGF-?/Smad and Wnt/?-Catenin Pathways. (Pubmed Central) - Jan 28, 2026
In vivo, unilateral ureteral obstruction (UUO) and adenine (Ade)-induced mouse models were treated with a low/high-dose 7-KLCA or losartan...It upregulated FXR and its downstream genes SHP and FGF15, thereby inhibiting the activation of TGF-?/Smad and Wnt/?-catenin pathways. This is the first study to clarify the molecular mechanism through which 7-KLCA targets FXR and dually suppresses the key pro-fibrotic pathways TGF-?/Smad and Wnt/?-catenin, thereby exerting anti-renal fibrosis effects.
- | Journal: Multi-Omics and Functional Analyses Identify let-7b-3p as a Negative Regulator of EMT in Lung Adenocarcinoma. (Pubmed Central) - Jan 26, 2026
signaling pathway and EMT. These findings highlight the originality of this work and underscore the potential clinical translational value of targeting let-7b-3p or the HMGA2-LIN28A axis as novel therapeutic strategies for LUAD.
- | Journal: A pH-responsive dual-drug nanoplatform for stromal remodeling and enhanced chemotherapy via MMP3/TGF-? inhibition. (Pubmed Central) - Jan 26, 2026
suppresses the pro-fibrotic MMP3/TGF-?/Smad signaling axis in our CAF model. This work therefore introduces a dual-action therapeutic concept, offering a mechanistically-defined approach to disrupt stromal barriers and improve drug efficacy at the pre-clinical proof-of-concept stage.
- | Journal: Neutrophil-derived exosomal thrombospondin-1 exacerbates endothelial progenitor cell senescence and lung injury via TGF-?/SMAD signaling in COPD. (Pubmed Central) - Jan 25, 2026
This work therefore introduces a dual-action therapeutic concept, offering a mechanistically-defined approach to disrupt stromal barriers and improve drug efficacy at the pre-clinical proof-of-concept stage. This study demonstrates that neutrophil-derived exosomal TSP-1 aggravates EPC senescence and lung injury in COPD, revealing the pathogenic role of TSP-1 in disease progression and highlighting its potential as a therapeutic target.
- | Journal: A chalcone-rich extract from licorice root inhibits liver steatosis and fibrosis via regulating PPAR? and TGF? signaling. (Pubmed Central) - Jan 23, 2026
Importantly, our study unravels the active component - Z018B and highlights the synergistic therapeutic effect of different active substances in Z018B. The potent therapeutic effect of Z018B on MASLD warrants its further development.
- | Journal, Heterogeneity: Multiomics Analysis for Predicting Pathological Complete Response in Triple-Negative Breast Cancer and Reflecting Tumor Heterogeneity. (Pubmed Central) - Jan 22, 2026
Chemotherapy combined with targeting the TGF-? pathway is a potential strategy to overcome drug resistance in TNBC.
- | Journal: Endoglin Regulates Pluripotency and Differentiation in Human Embryonic Stem Cells Through Wnt and TGF-? Signaling Crosstalk. (Pubmed Central) - Jan 22, 2026
Notably, blocking WNT secretion with IWP2 suppressed spontaneous peripheral differentiated cell formation and partially restored ectodermal and endodermal differentiation. These findings establish a novel regulatory role for ENG in balancing WNT signaling, to preserve hPSCs' developmental potential, thereby illuminating an unrecognized mechanism of stem cell fate control and revealing ENG as a critical mediator of hPSCs' self-renewal and lineage fidelity.
- | nintedanib / Generic mfg., pirfenidone / Generic mfg.
Review, Journal: Advances in the research and application of stem cell therapies for idiopathic pulmonary fibrosis. (Pubmed Central) - Jan 22, 2026
Bioengineering advancements, including hydrogel scaffolds and 3D lung organoids, enhance stem cell retention and provide platforms for IPF research and drug screening. This review explores the therapeutic potential of stem cell therapies in IPF, integrating recent bioengineering developments and clinical prospects.
- | Journal: ?-sitosterol ameliorates myocardial infarction injury via modulating the NF-?B and necroptosis signaling pathways. (Pubmed Central) - Jan 22, 2026
?-SITO demonstrates significant therapeutic potential for improving post-MI recovery. Its cardioprotective effects are likely mediated through the modulation of NF-?B and necroptosis signaling pathways, highlighting it as a promising candidate for MI treatment.
- | Biomarker, Journal: Integration of single cell and bulk transcriptomic analyses identifies FAM189A2 as a key prognostic gene in lung cancer. (Pubmed Central) - Jan 22, 2026
Integrating single-cell and bulk transcriptomes links malignant epithelial state programs to prognosis, yields a practical eight-gene risk model validated in multiple LUAD cohorts, and nominates FAM189A2 as a putative tumor suppressor and potential biomarker in lung cancer. These findings suggest testable strategies for risk stratification and therapy selection that warrant prospective evaluation.