| Brochard, Laurent |
OWED, NCT02539732: Prediction of Outcome of Weaning From Mechanical Ventilation Using the Electrical Activity of the Diaphragm |
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| Recruiting | N/A | 110 | Europe, Canada | | Unity Health Toronto | Respiratory Insufficiency | 12/21 | 12/21 | | |
NCT03902639: Examining the Effects of Nasal High Flow Oxygen Therapy Compared to Non-invasive Ventilation in Health Volunteers |
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| Recruiting | N/A | 10 | Canada | | Unity Health Toronto | Healthy Volunteers | 12/24 | 12/24 | | |
| Recruiting | N/A | 171 | Europe, Canada, RoW | Specific lung recruitment maneuvers | Unity Health Toronto | Acute Respiratory Distress Syndrome (ARDS) | 12/21 | 06/22 | | |
HiFOLD, NCT03033251: High Flow Nasal Cannula Versus Non-Invasive Ventilation in Exacerbations of Chronic Obstructive Pulmonary Disease |
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| Recruiting | N/A | 30 | Canada | Non Invasive Ventilation, Standard of Care, High Flow Oxygen Cannula 50, HFNO 50, High Flow Oxygen Cannula 30, HFNO 30 | Unity Health Toronto | Exacerbation Copd, Acute Respiratory Distress, Acute Hypercapnic Respiratory Failure | 07/24 | 07/24 | | |
| Recruiting | N/A | 300 | Europe, Canada, RoW | | Unity Health Toronto | ARDS, Acute Hypoxemic Respiratory Failure | 08/22 | 08/22 | | |
| Not yet recruiting | N/A | 72 | Canada, US | Venovenous ECMO | University of Toronto, University Health Network, Toronto | ARDS | 06/23 | 12/23 | | |
| Recruiting | N/A | 30 | Canada | Mechanical Ventilation | Unity Health Toronto | Respiratory Support | 06/23 | 06/23 | | |
PROMIZING, NCT02447692: Proportional Assist Ventilation for Minimizing the Duration of Mechanical Ventilation: The Study |
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| Completed | N/A | 575 | Europe, Canada, RoW | PSV ventilation strategy, PAV+ ventilation strategy | Lawson Health Research Institute, Canadian Institutes of Health Research (CIHR), Medtronic, Canadian Critical Care Trials Group | Critically Ill, Acute Respiratory Failure | 07/24 | 07/24 | | |
VICTORY, NCT06196125: Ventilation dIstribution and effeCt of posTural Lateralization On Traumatic Lung injuRY: a Physiological Study |
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| Active, not recruiting | N/A | 24 | Canada | Four body positions | Unity Health Toronto | Trauma Chest, Mechanical Ventilation | 11/24 | 11/24 | | |
RENOVATE, NCT03643939: High-Flow Nasal Oxygen Cannula Compared to Non-Invasive Ventilation in Adult Patients With AcuTE Respiratory Failure |
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| Completed | N/A | 1801 | RoW | High Flow Nasal Catheter, Optiflow, Airvo, trans-nasal insufflation, Nasal High Flow, High Flow Nasal Cannula, nasal cannula with high-flow oxygen, Noninvasive ventilation, BiPAP, Non-invasive ventilation, Noninvasive positive pressure ventilation | Hospital do Coracao, Ministry of Health, Brazil, Berry Consultants | Respiratory Insufficiency, Respiratory Failure | 11/23 | 02/24 | | |
HONOUR, NCT05078034: HNFO With or Without Helmet NIV for Oxygenation Support in Acute Respiratory Failure Pilot RCT |
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| Recruiting | N/A | 200 | Canada | Helmet Non-Invasive Ventilation (HNIV), HNIV, High Flow Nasal Oxygen, HFNO | Sunnybrook Health Sciences Centre | Acute Hypoxemic Respiratory Failure | 02/25 | 02/25 | | |
| Recruiting | N/A | 40 | US | Stimit Activator 1 | Stimit AG | Diaphragm Issues | 12/24 | 03/25 | | |
| Recruiting | N/A | 299 | Canada | Acute hypoxemic respiratory failure patients on VV-ECMO | Lorenzo delSorbo, Unity Health Toronto | Acute Hypoxemic Respiratory Failure | 04/25 | 04/26 | | |
| Recruiting | N/A | 30 | Europe | EIT monitoring | Centre Hospitalier Universitaire, Amiens, Unity Health Toronto | Acute Respiratory Distress Syndrome, Acute Lung Injury | 05/24 | 05/24 | | |
SEVERE, NCT06293976: Susceptibility for Entrainment: Role of Ventilator Settings on the Occurrence of Reverse Triggering and Its Physiological Consequences - the SEVeRe Study |
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| Recruiting | N/A | 30 | Canada | Changes in the ventilator respiratory rate and tidal volume | Unity Health Toronto | Respiration, Artificial, Reverse Triggering | 03/26 | 03/26 | | |
| Recruiting | N/A | 740 | Europe, Canada, US, RoW | Respiratory Mechanics, Standard Ventilation Strategy | Unity Health Toronto, Canadian Institutes of Health Research (CIHR), University of Toronto, Applied Health Research Centre | ARDS | 11/25 | 03/26 | | |
INTRINSIC, NCT06445049: Intrinsic Respiratory Rate Assessment During Mechanical Ventilation to Accelerate Spontaneous Breathing and Extubation |
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| Not yet recruiting | N/A | 70 | NA | brief test | Unity Health Toronto | Reverse Triggering, Patient Ventilator Dyssynchrony | 06/27 | 06/27 | | |
PUMA, NCT06494085: Pressure Muscle Index and Threshold of Over-assistance During Pressure Support Ventilation |
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| Not yet recruiting | N/A | 20 | NA | Measuring Respiratory Mechanics, Randomized Pressure Support | Unity Health Toronto | Acute Hypoxemic Respiratory Failure | 02/25 | 02/25 | | |
| Recruiting | N/A | 40 | Canada | CNAP | The Hospital for Sick Children, Unity Health Toronto | Acute Respiratory Distress Syndrome | 12/24 | 12/24 | | |
| Not yet recruiting | N/A | 50 | NA | High-flow nasal cannula therapy | Unity Health Toronto | Acute Hypercapnic Respiratory Failure | 07/24 | 07/24 | | |
| Beck, Jennifer |
| Completed | N/A | 65 | Canada | | Unity Health Toronto | Evaluation of Preterm NAVA Catheter Placement | 05/23 | 05/23 | | |
| Friedrich, Jan |
| Recruiting | 3 | 200 | Canada | Magnesium sulfate and then Digoxin, Amiodarone | Sunnybrook Health Sciences Centre, Sunnybrook Research Institute | Atrial Fibrillation New Onset | 10/25 | 04/26 | | |
| Recruiting | 2/3 | 1096 | Canada, RoW | higher chloride crystalloid, lower chloride crystalloid | McMaster University, The Physicians' Services Incorporated Foundation, Canadian Institutes of Health Research (CIHR) | Sepsis, Septic Shock | 11/25 | 03/26 | | |
| Recruiting | N/A | 20 | Canada | 16h overnight duty, 24h overnight duty, Handover training | The Hospital for Sick Children, Sunnybrook Health Sciences Centre | Patient Safety, Well-being, Education | 03/26 | 06/26 | | |
| Not yet recruiting | N/A | 72 | Canada, US | Venovenous ECMO | University of Toronto, University Health Network, Toronto | ARDS | 06/23 | 12/23 | | |
| Muller, Matthew |
| Recruiting | 4 | 8000 | Europe, Canada, RoW | Cefazolin, Penicillin, Benzylpenicillin, Penicillin G, Clindamycin, Lincomycin, Vancomycin, Daptomycin, Effectiveness of early switch to oral antibiotics, Whole body FDG PET/CT Imaging | University of Melbourne, Berry Consultants, McGill University Health Centre/Research Institute of the McGill University Health Centre, Menzies School of Health Research, Aotearoa Clinical Trials, Queensland University of Technology, Sunnybrook Health Sciences Centre, Tan Tock Seng Hospital, Telethon Kids Institute, The Peter Doherty Institute for Infection and Immunity, The University of Queensland, UMC Utrecht, Radboud University Medical Center, King's College London, Rambam Health Care Campus, University College, London, Houston Medical Research Institute | Staphylococcus Aureus Bacteremia | 12/28 | 12/28 | | |
TAPER-V, NCT04138706: Initial Vancomycin Taper for the Prevention of Recurrent Clostridium Difficile Infection |
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| Active, not recruiting | 3 | 263 | Canada | Vancomycin, Placebos | McGill University Health Centre/Research Institute of the McGill University Health Centre, Canadian Institutes of Health Research (CIHR) | Clostridium Difficile Infection | 10/24 | 10/24 | | |
| Daley, Peter |
PETERPEN, NCT03671967: PipEracillin Tazobactam Versus MERoPENem for Treatment of Bloodstream Infections Caused by Cephalosporin-resistant Enterobacteriaceae |
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| Recruiting | 4 | 1084 | Canada, RoW | Piperacillin/tazobactam, Meropenem | Rambam Health Care Campus, Rabin Medical Center, University of Modena and Reggio Emilia, Tel Aviv Medical Center, Meir Medical Center, Soroka University Medical Center, The Chaim Sheba Medical Center, McGill University Health Centre/Research Institute of the McGill University Health Centre, Jewish General Hospital, Canadian Institutes of Health Research (CIHR), Hadassah Medical Organization | Beta Lactam Resistant Bacterial Infection, Enterobacteriaceae Infections, Bacteremia | 01/26 | 04/26 | | |
| Recruiting | 4 | 8000 | Europe, Canada, RoW | Cefazolin, Penicillin, Benzylpenicillin, Penicillin G, Clindamycin, Lincomycin, Vancomycin, Daptomycin, Effectiveness of early switch to oral antibiotics, Whole body FDG PET/CT Imaging | University of Melbourne, Berry Consultants, McGill University Health Centre/Research Institute of the McGill University Health Centre, Menzies School of Health Research, Aotearoa Clinical Trials, Queensland University of Technology, Sunnybrook Health Sciences Centre, Tan Tock Seng Hospital, Telethon Kids Institute, The Peter Doherty Institute for Infection and Immunity, The University of Queensland, UMC Utrecht, Radboud University Medical Center, King's College London, Rambam Health Care Campus, University College, London, Houston Medical Research Institute | Staphylococcus Aureus Bacteremia | 12/28 | 12/28 | | |
TAPER-V, NCT04138706: Initial Vancomycin Taper for the Prevention of Recurrent Clostridium Difficile Infection |
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| Active, not recruiting | 3 | 263 | Canada | Vancomycin, Placebos | McGill University Health Centre/Research Institute of the McGill University Health Centre, Canadian Institutes of Health Research (CIHR) | Clostridium Difficile Infection | 10/24 | 10/24 | | |
| Recruiting | 3 | 10000 | Canada | Paxlovid, Other | Unity Health Toronto, Health Canada, Canadian Institutes of Health Research (CIHR) | COVID-19 | 03/26 | 03/26 | | |
| Active, not recruiting | 3 | 2900 | Canada | Artesunate, Imatinib, Infliximab, Dexamethasone, LSALT Peptide | Sunnybrook Health Sciences Centre, AbbVie, Apotex Inc., World Health Organization, University of British Columbia, Arch Biopartners Inc. | COVID-19 | 03/24 | 05/24 | | |
| Recruiting | 3 | 4000 | Canada, US, RoW | Heparin | University of Manitoba, Canadian Institutes of Health Research (CIHR), Research Manitoba, Ozmosis Research Inc., Canadian Venous Thromboembolism Clinical Trials and Outcomes Research (CanVECTOR) Network, Canadian Critical Care Trials Group, AVANTI | Community-acquired Pneumonia | 03/28 | 03/29 | | |
NCT03988855: An Exploratory, Open-Label, Oligo-Center Study to Evaluate the Safety, Efficacy, and Pharmacokinetics of Intravenous DNV3837 in Subjects With Clostridium Difficile Infection |
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| Recruiting | 2 | 40 | Canada, US | DNV3837 | Deinove | Clostridium Difficile (C. Difficile) | 12/22 | 12/22 | | |
| Completed | N/A | 3622 | Europe, Canada, US, RoW | 7 days of adequate antibiotic treatment, 14 days of adequate antibiotic treatment. | Sunnybrook Health Sciences Centre | Bacteremia, Intensive Care, Critically Ill, Sepsis, Mortality, Antimicrobial | 05/23 | 08/23 | | |
NCT06537609: A Platform Trial for Gram Negative Bloodstream Infections |
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| Recruiting | N/A | 2500 | Canada | De-escalation VS No De-escalation, Oral beta-lactams VS non beta-lactams, Central vascular catheter retention VS Central vascular catheter replacement, Cephalosporin VS Carbapenem for low risk AmpC organisms, Routine follow-up blood culture VS No routine follow-up blood culture | Sunnybrook Health Sciences Centre, Canadian Institutes of Health Research (CIHR) | Gram-negative Bacteremia | 04/27 | 04/28 | | |
| Completed | N/A | 174 | Canada | De-escalation VS No De-escalation, Oral beta-lactams VS non beta-lactams, Central vascular catheter retention VS Central vascular catheter replacement, Cephalosporin VS Carbapenem for low risk AmpC organisms, Routine follow-up blood culture VS No routine follow-up blood culture | Sunnybrook Health Sciences Centre, Canadian Institutes of Health Research (CIHR) | Gram-negative Bacteremia | 07/24 | 08/24 | | |
| TBA |
| Not yet recruiting | N/A | 72 | Canada, US | Venovenous ECMO | University of Toronto, University Health Network, Toronto | ARDS | 06/23 | 12/23 | | |
NCT04762134: Doxycycline Intervention for Bacterial STI ChemoprOphylaxis (DISCO) |
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| Recruiting | N/A | 560 | Canada | Doxycycline Hyclate | Jonathan Troy Grennan, Canadian Institutes of Health Research (CIHR) | Bacterial Sexually Transmitted Diseases | 12/26 | 06/27 | | |
| Talib, Komal |
| Active, not recruiting | 3 | 187 | Canada, US | Escitalopram, Lexapro, Placebo, non-applicable | JHSPH Center for Clinical Trials, National Institute on Aging (NIA) | Dementia | 04/24 | 05/25 | | |
| James, Paula |
NCT04559880: Tranexamic Acid to Prevent Bleeding After Endoscopic Resection of Large Colorectal Polyps: A Pilot Project |
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| Completed | 4 | 25 | Canada | Tranexamic Acid Injection [Cyklokapron], Tranexamic Acid Oral Tablets [Cyklokapron] | Lawrence Charles Hookey, Queen's University | Polyp, Colorectal | 10/21 | 04/23 | | |
| Recruiting | N/A | 600 | Canada | Implementation of WAPPS-Hemo personalized dosing regimen | McMaster University | Hemophilia A, Hemophilia B | 09/22 | 09/23 | | |
| Not yet recruiting | N/A | 212 | Canada | Genetic testing for inherited bleeding disorders | Queen's University, Unity Health Toronto, The Ottawa Hospital | Bleeding Disorder | 12/26 | 04/27 | | |
| Fischer, Connie |
| Active, not recruiting | 3 | 187 | Canada, US | Escitalopram, Lexapro, Placebo, non-applicable | JHSPH Center for Clinical Trials, National Institute on Aging (NIA) | Dementia | 04/24 | 05/25 | | |
| Shanmuganathan, Arthishia |
| Active, not recruiting | 3 | 187 | Canada, US | Escitalopram, Lexapro, Placebo, non-applicable | JHSPH Center for Clinical Trials, National Institute on Aging (NIA) | Dementia | 04/24 | 05/25 | | |
NCT05563298: Neuro RX Gamma for Amnestic Mild Cognitive Impairment (aMCI) |
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| Recruiting | N/A | 20 | Canada | Neuro RX Gamma device, Sham Neuro RX Gamma device | Unity Health Toronto | MCI, Amnestic Mild Cognitive Disorder | 03/25 | 03/25 | | |
| Schwarz, Kevin |
| Recruiting | 4 | 8000 | Europe, Canada, RoW | Cefazolin, Penicillin, Benzylpenicillin, Penicillin G, Clindamycin, Lincomycin, Vancomycin, Daptomycin, Effectiveness of early switch to oral antibiotics, Whole body FDG PET/CT Imaging | University of Melbourne, Berry Consultants, McGill University Health Centre/Research Institute of the McGill University Health Centre, Menzies School of Health Research, Aotearoa Clinical Trials, Queensland University of Technology, Sunnybrook Health Sciences Centre, Tan Tock Seng Hospital, Telethon Kids Institute, The Peter Doherty Institute for Infection and Immunity, The University of Queensland, UMC Utrecht, Radboud University Medical Center, King's College London, Rambam Health Care Campus, University College, London, Houston Medical Research Institute | Staphylococcus Aureus Bacteremia | 12/28 | 12/28 | | |
| Chesney, Tyler |
| Recruiting | N/A | 210 | Canada | Self-reported online geriatric assessment (CHAMP) | University Health Network, Toronto | Cancer, Older Adults | 06/25 | 06/25 | | |
