| Desch, Steffen |
| Recruiting | N/A | 1247 | Europe, Canada, US | Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System | Edwards Lifesciences | Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation | 01/25 | 04/30 | | |
NCT05963620: Long-term Follow-up of a Randomized Comparison of Percutaneous Coronary Intervention Versus Coronary Artery Bypass Surgery |
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| Enrolling by invitation | N/A | 201 | Europe | percutaneous coronary intervention vs bypass graft surgery | Heart Center Leipzig - University Hospital | Coronary Stenosis, Coronary Artery Disease | 02/24 | 02/24 | | |
| Thiele, Holger |
REVERSE-FLOW, NCT02739711: Glycoprotein IIb/IIIa Inhibitors Versus Standard Therapy in Patients with Myocardial Infarction and No-reflow |
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| Active, not recruiting | 4 | 120 | Europe | Glycoprotein IIb/IIIa inhibitors | University of Luebeck | Acute Myocardial Infarction | 05/24 | 12/25 | | |
EPIDAURUS, NCT04981041: Escalated Single Platelet Inhibition for One Month Plus NOAC in Patients With Atrial Fibrillation and ACS Undergoing PCI |
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| Recruiting | 4 | 2334 | Europe | Prasugrel or Ticagrelor, Clopidogrel | Ludwig-Maximilians - University of Munich | Acute Coronary Syndrome, Atrial Fibrillation | 12/24 | 06/25 | | |
NCT06292013: A Study to Investigate the Effect of Lepodisiran on the Reduction of Major Adverse Cardiovascular Events in Adults With Elevated Lipoprotein(a) - ACCLAIM-Lp(a) |
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| Recruiting | 3 | 12500 | Europe, Canada, Japan, US, RoW | Lepodisiran Sodium, LY3819469, Placebo | Eli Lilly and Company | Atherosclerotic Cardiovascular Disease (ASCVD), Elevated Lp(a) | 03/29 | 03/29 | | |
| Recruiting | 3 | 650 | Europe, Canada, RoW | Alteplase, Placebo | Assistance Publique - Hôpitaux de Paris, Johannes Gutenberg University Mainz, Life Sciences Research Partners (D Collen Research Foundation), Canadian Institutes of Health Research (CIHR), Instituto de Salud Carlos III, International Network of VENous Thromboembolism Clinical Research Networks, Boehringer Ingelheim | Pulmonary Embolism | 09/25 | 08/27 | | |
| Completed | N/A | 420 | Europe | ECLS insertion, Revascularisation and optimal medical treatment | Helios Health Institute GmbH, Heart Center Leipzig - University Hospital, IHF GmbH - Institut für Herzinfarktforschung | Acute Myocardial Infarction, Cardiogenic Shock | 12/22 | 09/24 | | |
| Completed | N/A | 888 | Europe, US, RoW | | CoreAalst BV, Abbott Medical Devices | Coronary Artery Disease | 05/24 | 05/24 | | |
| Recruiting | N/A | 1247 | Europe, Canada, US | Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System | Edwards Lifesciences | Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation | 01/25 | 04/30 | | |
| Recruiting | N/A | 400 | Europe | | Leipzig Heart Science gGmbH, Helios Health Institute GmbH, Heart Center Leipzig - University Hospital, IHF GmbH - Institut für Herzinfarktforschung, Universitätsklinikum Hamburg-Eppendorf, St. Antonius Hospital, Klinikum Ludwigshafen, University of Magdeburg, Charite University, Berlin, Germany, University Hospital of Cologne | Out-of-hospital Cardiac Arrest | 12/25 | 06/26 | | |
| Recruiting | N/A | 202 | Europe | Selective CRP apheresis using the PentraSorb®-CRP system | Medical University Innsbruck | ST Elevation Myocardial Infarction, C-Reactive Protein, Apheresis, Myocardial Injury | 03/24 | 03/25 | | |
| Completed | N/A | 692 | Europe, US | Catheter-Directed Thrombolysis, FlowTriever System | Inari Medical | Pulmonary Embolism, Pulmonary Thrombo-embolism | 03/24 | 04/24 | | |
| Recruiting | N/A | 315 | Europe | Early Catheter-Interventional Treatment, Conventional care | Leipzig Heart Science gGmbH, Heart Center Leipzig at University of Leipzig, Helios Health Institute GmbH | Pulmonary Embolism Acute Massive | 06/27 | 06/27 | | |
DOUBLE-CHOICE, NCT05036018: RanDOmized stUdy Comparing Both Latest Generation Self-Expanding Valves and a Minimalist approaCH vs. Standard Of Care In transCathEter Aortic Valve Implantation |
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| Active, not recruiting | N/A | 836 | Europe | ACURATE neo2, minimalist approach, CoreValve Evolut Pro and Pro+, Standard of care | Leipzig Heart Science gGmbH, Heart Center Leipzig - University Hospital | Aortic Valve Stenosis | 02/25 | 12/33 | | |
PROVE, NCT05539573: ACURATE neo2™ - Post Market Safety and Performance Surveillance in Aortic Stenosis |
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| Active, not recruiting | N/A | 1043 | Europe | Planned TAVI with the ACURATE neo2™ aortic bioprosthesis and ACURATE neo2™ transfemoral delivery system. | University of Leipzig, National University of Ireland, Galway | Aortic Stenosis | 04/25 | 04/25 | | |
| Recruiting | N/A | 1054 | Europe | measurement of FFR, measurement of Pd/Pa | Helios Health Institute GmbH, Heart Center Leipzig - University Hospital | Coronary Artery Disease, Coronary Artery Stenoses | 05/26 | 11/26 | | |
RIP-HIGH, NCT04844931: Remote Ischemic Conditioning With Local Ischemic Postconditioning in High-Risk ST-elevation Myocardial Infarction |
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| Active, not recruiting | N/A | 250 | Europe | RIC + PostC + Standard PCI, Standard PCI | Helios Health Institute GmbH, Heart Center Leipzig - University Hospital | ST Elevation Myocardial Infarction | 12/25 | 07/30 | | |
APOLLO-EU, NCT05496998: Transcatheter Mitral Valve Replacement in Patients With Severe Symptomatic Mitral Regurgitation - Trial |
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| Recruiting | N/A | 400 | Europe | Medtronic Intrepid™ TMVR TF System | Medtronic Cardiovascular | Mitral Regurgitation | 08/29 | 12/38 | | |
| Recruiting | N/A | 3390 | Europe | Culprit-lesion revascularization, Culprit-lesion PCI, Non-culprit-lesion revascularization, multivessel PCI | Leipzig Heart Science gGmbH, Heart Center Leipzig at University of Leipzig, German Federal Ministry of Education and Research, IHF GmbH - Institut für Herzinfarktforschung, Stiftung IHF - Institut für Herzinfarktforschung | Non-ST-elevation Myocardial Infarction, Multivessel Coronary Artery Disease | 01/27 | 07/27 | | |
| Griesinger, Georg |
NCT03507673: Clinical Cohort Study on the Endocrinology and Vaginal/Endometrial Microbiome of the Luteal Phase in Assisted Reproduction |
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| Recruiting | N/A | 1200 | Europe | Blood samples and microbiological swaps | University of Luebeck | Infertility | 12/24 | 12/24 | | |
| Eitel, Ingo |
REVERSE-FLOW, NCT02739711: Glycoprotein IIb/IIIa Inhibitors Versus Standard Therapy in Patients with Myocardial Infarction and No-reflow |
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| Active, not recruiting | 4 | 120 | Europe | Glycoprotein IIb/IIIa inhibitors | University of Luebeck | Acute Myocardial Infarction | 05/24 | 12/25 | | |
| Not yet recruiting | 3 | 3000 | NA | SGLT2, Placebo | Prof. Dr. med. Ingo Eitel | Atrial Hypertension | 05/32 | 05/32 | | |
| Recruiting | 2/3 | 130 | Europe | Mycophenolate Mofetil, MMF, Prednisolone, Mycophenolate Mofetil Placebo, MMF Placebo, Prednisolone Placebo | LMU Klinikum, Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK), Technical University of Munich, Charite University, Berlin, Germany, University Hospital, Essen, University Hospital Erlangen, University Hospital Tuebingen | Inflammatory Cardiomyopathy | 03/27 | 03/28 | | |
TriCLASP, NCT04614402: Transcatheter Repair of Tricuspid Regurgitation With Edwards PASCAL Transcatheter Valve Repair System |
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| Active, not recruiting | N/A | 300 | Europe | Edwards PASCAL Transcatheter Valve Repair System, Edwards PASCAL Precision Transcatheter Valve Repair System | Edwards Lifesciences | Tricuspid Valve Insufficiency | 04/23 | 03/28 | | |
CMR-ICD, NCT04558723: Cardiac Magnetic Resonance Guidance of Implantable Cardioverter Defibrillator Implantation in Non-ischemic Dilated Cardiomyopathy |
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| Recruiting | N/A | 760 | Europe | ICD/CRT-D implantation | Prof. Dr. med. Ingo Eitel, Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK) | Non-ischemic Dilated Cardiomyopathy | 11/27 | 11/27 | | |
| Recruiting | N/A | 1000 | Europe | Edwards PASCAL Transcatheter Valve Repair System and Edwards PASCAL Precision Transcatheter Valve Repair System | Edwards Lifesciences | Mitral Regurgitation, Mitral Insufficiency | 12/25 | 03/31 | | |
LAA-KIDNEY, NCT05204212: Left Atrial Appendage Closure in Patients With Non-valvular Atrial Fibrillation and End-stage Chronic KIDNEY Disease |
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| Recruiting | N/A | 430 | Europe | Left Atrial Appendage closure | Prof. Dr. med. Ingo Eitel | Non-valvular Atrial Fibrillation (NVAF): Paroxysmal, Persistent, Permanent | 01/26 | 01/28 | | |
| Recruiting | N/A | 202 | Europe | Selective CRP apheresis using the PentraSorb®-CRP system | Medical University Innsbruck | ST Elevation Myocardial Infarction, C-Reactive Protein, Apheresis, Myocardial Injury | 03/24 | 03/25 | | |
| Recruiting | N/A | 750 | Europe, Canada, US, RoW | Corvia Atrial Shunt System / IASD System II, Intra-cardiac echocardiography (ICE), or transesophageal echocardiography (TEE) | Corvia Medical | Heart Failure, Heart Failure, Diastolic | 05/25 | 03/31 | | |
| Recruiting | N/A | 475 | Europe, Canada, US | Amulet™ 2 Left Atrial Appendage (LAA) Occluder | Abbott Medical Devices | Atrial Fibrillation (AF), Stoke | 07/26 | 07/28 | | |
| Recruiting | N/A | 2650 | Europe, Canada, Japan, US, RoW | Left Atrial Appendage Occlusion (Amplatzer Amulet LAA Occluder), Amplatzer Amulet LAA Occluder, Non-Vitamin K Oral Antagonists, NOAC | Abbott Medical Devices | Atrial Fibrillation, Stroke, Bleeding | 08/27 | 08/30 | | |
| Recruiting | N/A | 500 | Europe | | Prof. Dr. med. Ingo Eitel, University of Foggia | Takotsubo Syndrome | 01/25 | 01/25 | | |
OCTACOR, NCT06493994: Myval TransAXillary Transcatheter Aortic Valve Replacement Multicenter Clinical Registry |
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| Recruiting | N/A | 100 | Europe | transaxillary (TAX) transcatheter aortic valve replacement | University of Luebeck, University Hopsital Schleswig Holstein Campus Lübeck | Aortic Valve Stenosis | 01/27 | 01/27 | | |
NCT05069558: Comparing PFO Outcomes of the Occlutech Flex II PFO Occluder to Standard of Care PFO Occlusion |
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| Active, not recruiting | N/A | 450 | Europe, Canada, US | Investigational PFO Closure Device, Standard of Care PFO Closure Device | Occlutech International AB | Stroke, Patent Foramen Ovale, PFO | 11/25 | 10/26 | | |
RIP-HIGH, NCT04844931: Remote Ischemic Conditioning With Local Ischemic Postconditioning in High-Risk ST-elevation Myocardial Infarction |
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| Active, not recruiting | N/A | 250 | Europe | RIC + PostC + Standard PCI, Standard PCI | Helios Health Institute GmbH, Heart Center Leipzig - University Hospital | ST Elevation Myocardial Infarction | 12/25 | 07/30 | | |
| Recruiting | N/A | 3390 | Europe | Culprit-lesion revascularization, Culprit-lesion PCI, Non-culprit-lesion revascularization, multivessel PCI | Leipzig Heart Science gGmbH, Heart Center Leipzig at University of Leipzig, German Federal Ministry of Education and Research, IHF GmbH - Institut für Herzinfarktforschung, Stiftung IHF - Institut für Herzinfarktforschung | Non-ST-elevation Myocardial Infarction, Multivessel Coronary Artery Disease | 01/27 | 07/27 | | |
CLEARANCE, NCT04298723: Comparison of LAA-Closure vs Oral Anticoagulation in Patients With NVAF and Status Post Intracranial Bleeding. |
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| Recruiting | N/A | 530 | Europe | Percutaneous closure of the LAA (Watchman / Watchman FLX) | Jena University Hospital | Atrial Fibrillation (AF), Intracranial Bleed | 06/27 | 06/27 | | |
| Klein, Christine |
| Active, not recruiting | N/A | 25000 | Europe, Canada, US, RoW | | CENTOGENE GmbH Rostock | Parkinson´s Disease | 12/25 | 12/25 | | |
| Recruiting | N/A | 4500 | Europe, Canada, US, RoW | | Michael J. Fox Foundation for Parkinson's Research, Institute for Neurodegenerative Disorders | Parkinson Disease | 12/33 | 12/33 | | |
| Videnovic, Aleksandar |
| Recruiting | 2 | 1074 | US | Modafinil, Modafinil Placebo, Solriamfetol, Solriamfetol Placebo, Melatonin, Melantonin Placebo, Tailored lighting (TL) Active, Tailored lighting (TL) Placebo | Duke University | Long COVID, Long COVID-19, Hypersomnia, Sleep Disturbance | 07/25 | 07/25 | | |
NCT02909192: Bright Light Therapy for Non-motor Symptoms in Parkinson's Disease |
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| Recruiting | N/A | 65 | US | Light Therapy Device | Massachusetts General Hospital | Parkinson's Disease | 12/21 | 12/21 | | |
| Recruiting | N/A | 30 | US | | Massachusetts General Hospital | Rapid Eye Movement Sleep Behavior Disorder | 12/21 | 12/21 | | |
| Recruiting | N/A | 4500 | Europe, Canada, US, RoW | | Michael J. Fox Foundation for Parkinson's Research, Institute for Neurodegenerative Disorders | Parkinson Disease | 12/33 | 12/33 | | |
| Bruggermann, Norbert |
| Recruiting | N/A | 4500 | Europe, Canada, US, RoW | | Michael J. Fox Foundation for Parkinson's Research, Institute for Neurodegenerative Disorders | Parkinson Disease | 12/33 | 12/33 | | |
| Center, PPMI Call |
| Recruiting | N/A | 4500 | Europe, Canada, US, RoW | | Michael J. Fox Foundation for Parkinson's Research, Institute for Neurodegenerative Disorders | Parkinson Disease | 12/33 | 12/33 | | |
| Eggersmann, Tanja |
NCT05173597: Real-world Evidence on Follitropin Delta Individual Dosing |
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| Recruiting | N/A | 850 | Europe | Follitropin delta, REKOVELLE® (follitropin delta) | University of Luebeck | Infertility, Sterility | 12/24 | 12/25 | | |
| Recruiting | N/A | 140 | Europe | autologous PRP (platelet rich plasma), Saline solution (NaCL) Injection | University of Luebeck | Premature Ovarian Insufficiency, Infertility, Female, Sterility, Female, PRP | 03/25 | 03/28 | | |
NCT03507673: Clinical Cohort Study on the Endocrinology and Vaginal/Endometrial Microbiome of the Luteal Phase in Assisted Reproduction |
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| Recruiting | N/A | 1200 | Europe | Blood samples and microbiological swaps | University of Luebeck | Infertility | 12/24 | 12/24 | | |
| Griesing, Georg |
| Recruiting | N/A | 140 | Europe | autologous PRP (platelet rich plasma), Saline solution (NaCL) Injection | University of Luebeck | Premature Ovarian Insufficiency, Infertility, Female, Sterility, Female, PRP | 03/25 | 03/28 | | |
| Edimiris, Philippos |
NCT03507673: Clinical Cohort Study on the Endocrinology and Vaginal/Endometrial Microbiome of the Luteal Phase in Assisted Reproduction |
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| Recruiting | N/A | 1200 | Europe | Blood samples and microbiological swaps | University of Luebeck | Infertility | 12/24 | 12/24 | | |
