University of Minnesota Medical Center
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 103 Trials 
187 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Miller, Jeffrey
NCT05427981: Anti-suicidal Effects of Buprenorphine In Depressed Individuals

Withdrawn
3
30
US
Belbuca Buccal Product, Placebo
New York State Psychiatric Institute
Suicidal Ideation, Major Depressive Disorder
01/24
01/24
NCT04786548: Neuroinflammation in Patients With OCD

Active, not recruiting
2
21
US
Celecoxib, Celebrex
New York State Psychiatric Institute
Obsessive-Compulsive Disorder
08/25
08/25
STAR-T, NCT04976530: Safe and Timely Antithrombotic Removal - Ticagrelor

Completed
N/A
140
Canada, US
DrugSorb-ATR system, Sorbent hemoperfusion system, Sham comparator
CytoSorbents, Inc
Hemorrhage, Surgical, Blood Loss, Surgical, Blood Loss, Postoperative, Hemorrhage Postoperative
08/23
08/23
NCT06203054: CLIP-IT Post-Market Study

Recruiting
N/A
150
US
Penditure™ Left Atrial Appendage (LAA) Exclusion System
Medtronic Cardiac Surgery
Left Atrial Appendage Exclusion
11/25
02/29
NCT04795765: SpineJack System Postmarket Registry

Completed
N/A
261
US
SpineJack system, Balloon kyphoplasty, Vertebroplasty
Stryker Instruments, Talosix
Osteoporotic Vertebral Compression Fractures
11/24
11/24
STAND, NCT04835428: - Study of the AGN1 LOEP SV Kit Compared to PMMA in Patients with Vertebral Compression Fractures

Recruiting
N/A
408
US
Treatment Group: AGN1 LOEP SV Kit, Control Group: PMMA bone cement
AgNovos Healthcare, LLC
Vertebral Compression Fracture, Compression Fracture, Vertebral Compression
12/25
12/27
Raymond, Gerald V
NCT02233257: Expanded Access for Lorenzo's Oil (GTO/GTE) in Adrenoleukodystrophy

No Longer Available
N/A
US
Lorenzo's Oil, Glyceryl trierucate
University of Minnesota
X-linked Adrenoleukodystrophy
 
 
Whitley, Chester B
STARLIGHT, NCT04573023 / 2020-003200-14: A Phase III Study of JR-141 in Patients With Mucopolysaccharidosis II

Recruiting
3
80
Europe, US, RoW
JR-141, Idursulfase, JR-141 or Idursulfase
JCR Pharmaceuticals Co., Ltd., JCR Pharmaceuticals Co., Ltd.
Mucopolysaccharidosis II
01/26
01/26
STAAR, NCT04046224 / 2019-000667-24: Dose-Ranging Study of ST-920, an AAV2/6 Human Alpha Galactosidase A Gene Therapy in Subjects With Fabry Disease

Active, not recruiting
1/2
34
Europe, Canada, US, RoW
ST-920
Sangamo Therapeutics
Fabry Disease
04/25
09/25
NCT06567769: Phase 1 Study of GC1130A in Pediatric Patients with Sanfilippo Syndrome Type a (MPS IIIA)

Recruiting
1
9
US, RoW
GC1130A
GC Biopharma Corp, Novel Pharma Inc.
Sanfilippo Syndrome Type a
06/27
06/27
NCT00668187: A Natural History Study of the Gangliosidoses

Recruiting
N/A
52
US
University of Minnesota, Rare Diseases Clinical Research Network, National Center for Advancing Translational Sciences (NCATS), National Institute of Neurological Disorders and Stroke (NINDS), National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Lysosomal Disease Network
Tay-Sachs Disease, Sandhoff Disease, Late Onset Tay-Sachs Disease, GM1 Gangliosidosis, GM2 Gangliosidosis
03/27
03/27
Orchard, Paul J
NCT02171104: MT2013-31: Allo HCT for Metabolic Disorders and Severe Osteopetrosis

Recruiting
2
100
US
Stem Cell Transplantation, IMD Preparative Regimen, Osteopetrosis Only Preparative Regimen, Osteopetrosis Haploidentical Only Preparative Regimen, cALD SR-A (Standard-Risk, Regimen A), cALD SR-B (Standard-Risk, Regimen B), cALD HR-D (High-Risk, Regimen C), cALD HR-D (High-Risk, Regimen D)
Masonic Cancer Center, University of Minnesota
Mucopolysaccharidosis Disorders, Hurler Syndrome, Hunter Syndrome, Maroteaux Lamy Syndrome, Sly Syndrome, Alpha-Mannosidosis, Fucosidosis, Aspartylglucosaminuria, Glycoprotein Metabolic Disorders, Sphingolipidoses, Recessive Leukodystrophies, Globoid Cell Leukodystrophy, Metachromatic Leukodystrophy, Niemann-Pick B, Niemann-Pick C Subtype 2, Sphingomyelin Deficiency, Peroxisomal Disorders, Adrenoleukodystrophy With Cerebral Involvement, Zellweger Syndrome, Neonatal Adrenoleukodystrophy, Infantile Refsum Disease, Acyl-CoA Oxidase Deficiency, D-Bifunctional Enzyme Deficiency, Multifunctional Enzyme Deficiency, Alpha-methylacyl-CoA Racmase Deficiency, Mitochondrial Neurogastrointestingal Encephalopathy, Severe Osteopetrosis, Hereditary Leukoencephalopathy With Axonal Spheroids (HDLS; CSF1R Mutation), Inherited Metabolic Disorders
07/25
07/28
NCT05682144: ISP-001: Sleeping Beauty Transposon-Engineered B Cells for MPS I

Recruiting
1
2
US
Autologous Plasmablasts (B cells)
Immusoft of CA, Inc.
Mucopolysaccharidosis IH/S, Mucopolysaccharidosis IS
06/25
06/39
NCT03047369: The Myelin Disorders Biorepository Project

Recruiting
N/A
12000
US
Children's Hospital of Philadelphia, National Institutes of Health (NIH), National Institute of Neurological Disorders and Stroke (NINDS), National Center for Advancing Translational Sciences (NCATS), Biogen, Eli Lilly and Company, Myrtelle Inc., Orchard Therapeutics Ltd., Passage Bio, Inc., Synaptix Biotherapeutics Ltd., Takeda, Boehringer Ingelheim, Ionis Pharmaceuticals, Inc., Sanofi Winthrop Industrie, Sana Biotechnology, Yaya Foundation for 4H Leukodystrophy, University of Pennsylvania, United MSD Foundation, Foundation to Fight H-ABC, Calliope Joy Foundation, Don't Forget Me Foundation
Leukodystrophy, White Matter Disease, Leukoencephalopathies, 4H Syndrome, Adrenoleukodystrophy, AMN, ALD, ALD Gene Mutation, ALD (Adrenoleukodystrophy), X-linked Adrenoleukodystrophy, X-ALD, Adrenomyeloneuropathy, Aicardi Goutieres Syndrome, AGS, Alexander Disease, Alexanders Leukodystrophy, AxD, ADLD, Canavan Disease, CTX, Cerebrotendinous Xanthomatoses, Krabbe Disease, GALC Deficiency, Globoid Leukodystrophy, TUBB4A-Related Leukodystrophy, H-ABC - Hypomyelination, Atrophy of Basal Ganglia and Cerebellum, HBSL, HBSL - Hypomyelination, Brain Stem, Spinal Cord, Leg Spasticity, LBSL, Leukoencephalopathy With Brain Stem and Spinal Cord Involvement and High Lactate Syndrome (Disorder), Leukoencephalopathy With Brainstem and Spinal Cord Involvement and Lactate Elevation, ALSP, CSF1R Gene Mutation, HCC - Hypomyelination and Congenital Cataract, MLC1, Megalencephalic Leukoencephalopathy With Subcortical Cysts, MLD, Metachromatic Leukodystrophy, PMD, Pelizaeus-Merzbacher Disease, PLP1 Null Syndrome, PLP1 Gene Duplication | Blood or Tissue | Mutations, Pelizaeus Merzbacher Like Disease, Peroxisomal Biogenesis Disorder, Zellweger Syndrome, Refsum Disease, Salla Disease, Sialic Storage Disease, Sjögren, Sjogren-Larsson Syndrome, Van Der Knapp Disease, Vanishing White Matter Disease, Charcot-Marie-Tooth, CMT, Mct8 (Slc16A2)-Specific Thyroid Hormone Cell Transporter Deficiency, Allan-Herndon-Dudley Syndrome, Cadasil, Cockayne Syndrome, Multiple Sulfatase Deficiency, Gangliosidoses, GM2 Gangliosidosis, BPAN, Labrune Syndrome, LCC, Mucopolysaccharidoses, TBCK-Related Intellectual Disability Syndrome
12/30
12/30
NCT05634512: Evaluation of Intravenous Laronidase Pharmacokinetics Before and After Hematopoietic Cell Transplantation in Patients With Mucopolysaccharidosis Type IH.

Recruiting
N/A
24
US
Laronidase therapy and a stem cell transplant
Masonic Cancer Center, University of Minnesota
Hematopoietic Cell Transplantation, Mucopolysaccharidosis Type I
10/25
10/26
Cheng, Edward
NCT02109952: Biomechanics of Metastatic Defects in Bone

Active, not recruiting
N/A
245
Canada, US
Beth Israel Deaconess Medical Center
Cancer Bone, Bone Tumors
12/25
12/25
BATON, NCT06123481: Autologous Bone Marrow Aspirate Treatment for Early-Stage Osteonecrosis

Not yet recruiting
N/A
192
US
Core Decompression, Core Decompression Procedure with Autologous Bone Marrow Aspirate Concentrate
Johns Hopkins University, Stanford University, Sinai Hospital of Baltimore, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Osteonecrosis of the Femoral Head, Avascular Necrosis of the Femoral Head
04/28
08/28
MacMillan, Margaret
NCT04248439: Gene Therapy for Fanconi Anemia, Complementation Group A

Active, not recruiting
2
5
US
RP-L102
Rocket Pharmaceuticals Inc.
Fanconi Anemia Complementation Group A
05/26
05/26
NCT02722668: UCB Transplant for Hematological Diseases Using a Non Myeloablative Prep

Active, not recruiting
2
16
US
Fludarabine, Fludara, Cyclophosphamide, Cytoxan, MMF, Mycophenolate Mofetil, Sirolimus, Rapamycin, TBI, Total body irradiation, Umbilical cord blood cell infusion, UCB, ATG, Anti-thymocyte Globulin
Masonic Cancer Center, University of Minnesota
Acute Leukemia, Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia/Lymphoma, Burkitt's Lymphoma, Natural Killer Cell Malignancies, Chronic Myelogenous Leukemia, Myelodysplastic Syndrome, Large-cell Lymphoma, Hodgkin Lymphoma, Multiple Myeloma, Relapsed Chronic Lymphocytic Leukemia, Relapsed Small Lymphocytic Lymphoma, Marginal Zone B-cell Lymphoma, Follicular Lymphoma, Lymphoplasmacytic Lymphoma, Mantle-cell Lymphoma, Prolymphocytic Leukemia, Bone Marrow Failure Syndromes, Myeloproliferative Neoplasms/Myelofibrosis, Biphenotypic/Undifferentiated/Prolymphocytic Leukemias, MRD Positive Leukemia, Leukemia or MDS in Aplasia, Relapsed T-Cell Lymphoma, Relapsed Multiple Myeloma, Plasma Cell Leukemia
02/23
12/29
NCT04965597: Treosulfan-Based Conditioning Regimen Before a Blood or Bone Marrow Transplant for the Treatment of Bone Marrow Failure Diseases (BMT CTN 1904)

Recruiting
2
40
US
Treosulfan, Dihydroxybusulfan, Ovastat, Treosulphan, Tresulfon, Trecondi, Fludarabine Phosphate, 2-fluoro-9-(5-O-phosphono-.beta.-D-arabinofuranosyl)-, 9H-purin-6-amine, 2-fluoro-9-(5-O-phosphono-beta-D-arabinofuranosyl), Beneflur, Fludara, Fludarabine-5'-Monophosphate, SH T 586, Tacrolimus, FK 506, Fujimycin, Hecoria, Prograf, Protopic, Methotrexate, Abitrexate, Alpha-Methopterin, Amethopterin, Brimexate, Emthexat, Emtexate, Farmitrexat, Methotrexate LPF, Methylaminopterin, Methotrexatum, Metotrexato, Novatrex, Rheumatrex, Texate, Tremetex, Trexeron, Trixilem, WR-19039, Lapine T-Lymphocyte Immune Globulin, Anti-Thymocyte Globulin Rabbit, Grafalon, Rabbit Anti-Human Thymocyte Globulin (RATG), Rabbit Anti-Thymocyte Globulin, Rabbit Antithymocyte Globulin, Rabbit ATG, rATG, Thymoglobulin, Antithymocyte globulin rabbit ATG, Imtix, Peripheral Blood Stem Cell Transplantation, PBPC transplantation, PBSCT, Peripheral Blood Progenitor Cell Transplantation, PERIPHERAL BLOOD STEM CELL TRANSPLANT, peripheral stem cell support, Peripheral Stem Cell Transplant, peripheral stem cell transplantation, Allogeneic Bone Marrow Transplantation, Allo BMT, Allogeneic Blood and Marrow Transplantation, Allogeneic BMT, Quality-of-Life Assessment, Quality of Life Assessment, Echocardiography, EC, Multigated Acquisition Scan, Blood Pool Scan, Equilibrium Radionuclide Angiography, Gated Blood Pool Imaging, Gated Heart Pool Scan, MUGA, Multi-Gated Acquisition Scan, MUGA Scan, Radionuclide Ventriculogram Scan, Radionuclide ventriculography, RNVG, SYMA Scanning, Synchronized Multigated Acquisition Scanning, Bone Marrow Biopsy, Bone Marrow Aspiration, Biospecimen Collection, Biological Sample Collection, X-Ray Imaging, Conventional X-Ray, Diagnostic Radiology, Computed Tomography, Computed Axial Tomography, CAT Scan, CT Scan
Fred Hutchinson Cancer Center, Blood and Marrow Transplant Clinical Trials Network, National Cancer Institute (NCI), National Marrow Donor Program, National Heart, Lung, and Blood Institute (NHLBI)
Bone Marrow Failure Syndrome, Congenital Amegakaryocytic Thrombocytopenia, Diamond-Blackfan Anemia, Hereditary Sideroblastic Anemia, Paroxysmal Nocturnal Hemoglobinuria, Shwachman-Diamond Syndrome, Hematologic Neoplasm With Germline GATA2 Mutation, Hematologic Neoplasm With Germline SAMD9 Mutation, Hematologic Neoplasm With Germline SAMD9L Mutation
12/25
12/26
NCT03579875: Alpha/Beta TCD HCT in Patients With Inherited BMF Disorders

Recruiting
2
48
US
Total Body Irradiation (TBI) (Plan 1), TBI, Cyclophosphamide (CY) (Plan 1), CY, Fludarabine (FLU), FLU, Methylprednisolone (MP), MP, Donor mobilized PBSC infusion, PBSC, G-CSF, Cyclophosphamide (CY) (Plan 2), Rituximab, Busulfan, BU, Alemtuzumab, Melphalan, MEL
Masonic Cancer Center, University of Minnesota
Fanconi Anemia, Severe Aplastic Anemia, Myelodysplastic Syndromes, T Cell Receptor Alpha/Beta Depletion, Telomere Biology Disorder, Bone Marrow Failure, Dyskeratosis Congenita
01/26
01/29
NCT05735717: MT2021-08T Cell Receptor Alpha/Beta Depletion PBSC Transplantation for Heme Malignancies

Recruiting
2
150
US
Fludarabine, Busulfan, Melphalan, Rituximab, Levetiracetam, Keppra
Masonic Cancer Center, University of Minnesota
Hematologic Malignancy, Acute Leukemia, Remission, Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, AML, TP53, Intrachromosomal Amplification of Chromosome 21, Cytogenetic Abnormality, CNS Leukemia, Minimal Residual Disease, Myelodysplasia, Juvenile Myelomonocytic Leukemia, Somatic Mutation, PTPN11 Gene Mutation, N-RAS Gene Amplification, Neurofibromatosis 1, NF1 Mutation, CBL Gene Mutation, Monosomy 7, Chromosome Abnormality, Fetal Hemoglobin
11/27
11/30
NCT00167219: Stem Cell Transplant for Juvenile Myelomonocytic Leukemia (JMML)

Completed
1/2
15
US
Stem Cell Transplant, Bone marrow transplantation, Preparative Regimen
Masonic Cancer Center, University of Minnesota
Juvenile Myelomonocytic Leukemia
07/22
08/23
NCT04044365: Pediatric cGVHD Symptom Scale

Recruiting
N/A
420
Canada, US
National Cancer Institute (NCI)
Graft vs Host Disease
12/25
12/25
Smith, Angela
NCT05555589: Assessment of the Safety and Efficacy of 0.1% RGN-259 Ophthalmic Solution for the Treatment of NK: SEER-2

Recruiting
3
70
US
RGN-259, Tβ4, Thymosin Beta 4, Timbetasin, Placebo, Vehicle Control
ReGenTree, LLC
Neurotrophic Keratopathy
07/24
11/24
AUGMENT-101, NCT04065399 / 2020-004104-34: A Study of Revumenib in R/R Leukemias Including Those With an MLL/KMT2A Gene Rearrangement or NPM1 Mutation

Jan 2024 - Dec 2024: Market entry for acute leukemias
Hourglass Feb 2024 - Mar 2024 : Q1'24 - PDUFA date from FDA for R/R KMT2Ar acute leukemia
Dec 2022 - Dec 2023: Submission in US for relapsed/refractory acute leukemia
Jul 2023 - Sep 2023: Data from AUGMENT-101 trial for r/r AML
Checkmark Updated data from P1 portion of P1/2 AUGMENT-101 trial for AML
More
Recruiting
1/2
413
Europe, Canada, US, RoW
revumenib, SNDX-5613, cobicistat
Syndax Pharmaceuticals, Syndax Pharmaceuticals, Inc
Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Mixed Lineage Acute Leukemia, Mixed Phenotype Acute Leukemia, Acute Leukemia of Ambiguous Lineage
12/27
12/27
FORTIS, NCT04174105: Gene Transfer Study in Patients With Late Onset Pompe Disease

Recruiting
1/2
18
Europe, US
zocaglusagene nuzaparvovec, AT845
Astellas Gene Therapies
Pompe Disease (Late-onset)
11/29
11/29
NCT04565431: Examining Effects of Tysabri on Cognitive Fatigue Using fMRI

Recruiting
N/A
25
US
Tysabri
Kessler Foundation, St. Barnabas Medical Center
Multiple Sclerosis, Relapsing-Remitting
12/24
12/24
NCT04448977: Examining Effects of Ocrevus on Cognitive Fatigue Using fMRI

Recruiting
N/A
60
US
Ocrevus
Kessler Foundation, Hackensack Meridian Health
Multiple Sclerosis, Relapsing-Remitting
12/24
12/24
NCT05399004: Evaluating Sexual Function in Women Undergoing a Radical Cystectomy for Bladder Cancer

Completed
N/A
34
NA
Survey Administration
Mayo Clinic, National Cancer Institute (NCI)
Bladder Carcinoma
06/24
06/24
NCT05045794: Bridge to HOPE: Hypothermic Oxygenated Perfusion Versus Cold Storage Prior to Liver Transplantation

Completed
N/A
219
US
VitaSmart Liver Machine Perfusion System, VitaSmart Liver Machine, Hypothermic oxygenated perfusion, Static cold storage
Bridge to Life Ltd.
End Stage Liver DIsease, Liver Failure
06/24
06/24
CISTO, NCT03933826: Comparison of Intravesical Therapy and Surgery as Treatment Options for Bladder Cancer

Active, not recruiting
N/A
572
US
University of Washington, Patient-Centered Outcomes Research Institute
Bladder Cancer, Cancer of the Bladder, Recurrent, Non-muscle Invasive Bladder Cancer
12/24
03/25
KOAR, NCT03326076: Evaluation of Patient Outcomes From the Kidney Allograft Outcomes AlloSure Registry

Active, not recruiting
N/A
4000
US
Donor-derived cell-free DNA (AlloSure®), Standard care, Peripheral blood gene expression profiling (AlloMap Kidney), Analytic platform (IBox)
CareDx
Kidney Transplant Rejection
06/25
12/25
Geller, Melissa A
NCT05708924: MT2021-27 FT538 Recurrent Ovarian, Fallopian Tube, and Primary Peritoneal Cancer

Suspended
1
33
US
FT538, Enoblituzumab, RES242, MGA271
Masonic Cancer Center, University of Minnesota, National Cancer Institute (NCI)
Cancer, Solid Tumor, Ovarian Cancer, Peritoneal Cancer, Fallopian Tube Cancer
09/26
09/28
NCT05322408: HCW9218 in Select Advanced Solid Tumors

Active, not recruiting
1
18
US
HCW9218, Monotherapy
Masonic Cancer Center, University of Minnesota
Solid Tumor
01/25
02/26
NCT05338658: Study of PAT in Patients With Solid Tumor Cancers

Suspended
1
21
US
Peptide Alarm Therapy (PAT), Pembrolizumab
Masonic Cancer Center, University of Minnesota
Metastasis, Solid Tumor
01/27
01/27
Greeno, Edward W
NCT06693986: Adenovirus (RGDCRAdCOX2F)

Recruiting
1
18
US
Replicative Adenovirus Vector (RGDCRAdCOX2F)
Masonic Cancer Center, University of Minnesota
Adenocarcinoma of Pancreas
10/28
10/29
Grant, Jon E
D1AMOND, NCT05615220: Ecopipam Tablets to Study Tourette's Disorder in Children, Adolescents and Adults

Active, not recruiting
3
196
Europe, Canada, US, RoW
Ecopipam Hydrochloride
Emalex Biosciences Inc.
Tourette Disorder
12/24
12/24
NCT05796752: Behavioral Treatment and Memantine in Body Focused Repetitive Behaviors

Recruiting
2/3
28
US
Memantine, Namenda, ComB Behavioral Therapy
University of Chicago
Skin-Picking, Trichotillomania (Hair-Pulling Disorder)
12/25
12/25
NCT02337634: Milk Thistle in Pathological Gambling

Completed
2
55
US
Placebo, Sugar Pill, Milk Thistle, Silymarin
University of Chicago
Pathological Gambling, Gambling Disorder
12/22
12/22
NCT04978428: Epidiolex in Obsessive Compulsive Disorder and Related Disorders

Recruiting
2
15
US
Cannabidiol, Epidiolex
University of Chicago
Obsessive-Compulsive Disorder, Trichotillomania (Hair-Pulling Disorder), Tourette Syndrome, Hoarding Disorder
11/25
11/25
NCT05356013: Caplyta in Borderline Personality Disorder

Recruiting
2
60
US
Caplyta, lumateperone, Placebo, no other names
University of Chicago, Intra-Cellular Therapies, Inc.
Borderline Personality Disorder
05/25
05/25
CL07-ORY-2001, NCT04932291 / 2020-003469-20: Study to Test the Efficacy and Safety of Vafidemstat in Adult Borderline Personality Disorder Population

Completed
2
210
Europe, US, RoW
vafidemstat, ORY-2001, Placebo
Oryzon Genomics S.A.
Borderline Personality Disorder
10/23
11/23
NCT05399498: Psilocybin in Co-occuring Major Depressive Disorder and Borderline Personality Disorder

Recruiting
2
10
US
Psilocybin
University of Chicago, Usona Institute
Borderline Personality Disorder, Major Depressive Disorder
03/25
04/25
NCT05545891: Aripiprazole in Body Focused Repetitive Behaviors

Not yet recruiting
2
100
US
Placebo, Aripiprazole, Abilify
University of Chicago
Trichotillomania (Hair-Pulling Disorder), Dermatillomania
10/26
10/26
CURB-2, NCT05262270: Extended-Release Naltrexone and Monthly Extended-Release Buprenorphine for Cocaine Use Disorder

Recruiting
2
426
US
Extended-Release Naltrexone, XR-NTX, Extended Release Buprenorphine, XR-BUP, Placebo (PLB) Injectable matched to XR-NTX, Injectable matching (to XR-NTX) placebo, Placebo (PLB) Injectable matched to XR-BUP, Injectable matching (to XR-BUP) placebo
University of Texas Southwestern Medical Center, National Institute on Drug Abuse (NIDA)
Cocaine Use Disorder
03/25
09/26
NCT05624528: A Clinical Trial of Tolcapone in Obsessive Compulsive Disorder

Recruiting
2
85
US
Tolcapone, Tasmar, Placebo
University of Chicago
Obsessive-Compulsive Disorder, OCD
06/25
07/25
NCT02770768: Effects of Flibanserin on the Pre- and Post-menopausal Female Brain

Terminated
N/A
57
US
Flibanserin, Addyi, Placebo, Matching placebo
University of Chicago
Hypoactive Sexual Desire Disorder
12/21
12/21
NCT01528982: Susceptibility to Pathological Gambling

Completed
N/A
588
US
Mindfulness, Training, Cognition
University of Chicago
Pathological Gambling
06/24
06/24
Verneris, Michael R
NCT05457556: Mismatched Related Donor Versus Matched Unrelated Donor Stem Cell Transplantation for Children, Adolescents, and Young Adults With Acute Leukemia or Myelodysplastic Syndrome

Recruiting
3
435
Canada, US, RoW
Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Bone Marrow Aspiration, Busulfan, 1, 4-Bis[methanesulfonoxy]butane, BUS, Busilvex, Bussulfam, Busulfanum, Busulfex, Busulphan, CB 2041, CB-2041, Glyzophrol, GT 41, GT-41, Joacamine, Methanesulfonic Acid Tetramethylene Ester, Methanesulfonic acid, tetramethylene ester, Mielucin, Misulban, Misulfan, Mitosan, Myeleukon, Myeloleukon, Myelosan, Mylecytan, Myleran, Sulfabutin, Tetramethylene Bis(methanesulfonate), Tetramethylene bis[methanesulfonate], WR-19508, Cyclophosphamide, (-)-Cyclophosphamide, 2H-1,3,2-Oxazaphosphorine, 2-[bis(2-chloroethyl)amino]tetrahydro-, 2-oxide, monohydrate, Asta B 518, B 518, B-518, B518, Carloxan, Ciclofosfamida, Ciclofosfamide, Cicloxal, Clafen, Claphene, CP monohydrate, CTX, CYCLO-cell, Cycloblastin, Cycloblastine, Cyclophospham, Cyclophosphamid monohydrate, Cyclophosphamide Monohydrate, Cyclophosphamidum, Cyclophosphan, Cyclophosphane, Cyclophosphanum, Cyclostin, Cyclostine, Cytophosphan, Cytophosphane, Cytoxan, Fosfaseron, Genoxal, Genuxal, Ledoxina, Mitoxan, Neosar, Revimmune, Syklofosfamid, WR 138719, WR- 138719, WR-138719, WR138719, Echocardiography, EC, Fludarabine, Fluradosa, Haploidentical Hematopoietic Cell Transplantation, Haploidentical Stem Cell Transplantation, HLA-Haploidentical Hematopoietic Cell Transplantation, Stem Cell Transplantation, Haploidentical, Lapine T-Lymphocyte Immune Globulin, Anti-Thymocyte Globulin Rabbit, Antithymocyte Globulin Rabbit, Antithymocyte globulin rabbit ATG, Grafalon, Imtix, Rabbit Anti-Human Thymocyte Globulin (RATG), Rabbit Anti-Thymocyte Globulin, Rabbit Antithymocyte Globulin, Rabbit ATG, Thymoglobulin, Lumbar Puncture, LP, Spinal Tap, Matched Unrelated Donor Hematopoietic Cell Transplantation, MUD-HCT, Melphalan, Alanine Nitrogen Mustard, CB-3025, L-PAM, L-Phenylalanine Mustard, L-Sarcolysin, L-Sarcolysin Phenylalanine mustard, L-Sarcolysine, Melphalan for Injection-Hepatic Delivery System, Melphalanum, Phenylalanine Mustard, Phenylalanine Nitrogen Mustard, Sarcoclorin, Sarkolysin, WR-19813, Methotrexate, Abitrexate, Alpha-Methopterin, Amethopterin, Brimexate, CL 14377, CL-14377, Emtexate, Emthexat, Emthexate, Farmitrexat, Fauldexato, Folex, Folex PFS, Lantarel, Ledertrexate, Lumexon, Maxtrex, Medsatrexate, Metex, Methoblastin, Methotrexate LPF, Methotrexate Methylaminopterin, Methotrexatum, Metotrexato, Metrotex, Mexate, Mexate-AQ, MTX, Novatrex, Rheumatrex, Texate, Tremetex, Trexeron, Trixilem, WR-19039, Multigated Acquisition Scan, Blood Pool Scan, Equilibrium Radionuclide Angiography, Gated Blood Pool Imaging, Gated Heart Pool Scan, MUGA, MUGA Scan, Multi-Gated Acquisition Scan, Radionuclide Ventriculogram Scan, Radionuclide Ventriculography, RNVG, SYMA Scanning, Synchronized Multigated Acquisition Scanning, Mycophenolate Mofetil, CellCept, MMF, Myeloablative Conditioning, Myeloablation, Myeloablative, Myeloablative Cytoreduction, Quality-of-Life Assessment, Quality of Life Assessment, Questionnaire Administration, Rituximab, ABP 798, BI 695500, BI-695500, BI695500, Blitzima, C2B8 Monoclonal Antibody, Chimeric Anti-CD20 Antibody, CT-P10, IDEC 102, IDEC-102, IDEC-C2B8, IDEC-C2B8 Monoclonal Antibody, IDEC102, Ikgdar, Mabtas, MabThera, Monoclonal Antibody IDEC-C2B8, PF 05280586, PF-05280586, PF05280586, Riabni, Ritemvia, Rituxan, Rituximab ABBS, Rituximab ARRX, Rituximab Biosimilar ABP 798, Rituximab Biosimilar BI 695500, Rituximab Biosimilar CT-P10, Rituximab Biosimilar GB241, Rituximab Biosimilar IBI301, Rituximab Biosimilar JHL1101, Rituximab Biosimilar PF-05280586, Rituximab Biosimilar RTXM83, Rituximab Biosimilar SAIT101, Rituximab Biosimilar SIBP-02, rituximab biosimilar TQB2303, Rituximab PVVR, Rituximab-abbs, Rituximab-arrx, Rituximab-blit, Rituximab-pvvr, Rituximab-rite, Rituximab-rixa, Rituximab-rixi, Rixathon, Riximyo, RTXM 83, RTXM-83, RTXM83, Ruxience, Truxima, T-Cell Depletion Therapy, T-Cell Depletion, T-Lymphocyte Depletion Therapy, Tacrolimus, FK 506, FK-506, FK506, Fujimycin, Hecoria, Prograf, Protopic, Tacforius, Thiotepa, 1,1',1''-Phosphinothioylidynetrisaziridine, Girostan, N,N', N''-Triethylenethiophosphoramide, Oncotiotepa, SH 105, SH-105, SH105, STEPA, Tepadina, Tepylute, TESPA, Tespamin, Tespamine, Thio-Tepa, Thiofosfamide, Thiofozil, Thiophosphamide, Thiophosphoamide, Thiophosphoramide, Thiotef, Tifosyl, TIO TEF, Tio-tef, Triethylene Thiophosphoramide, Triethylenethiophosphoramide, Tris(1-aziridinyl)phosphine sulfide, TSPA, WR 45312, Total-Body Irradiation, SCT_TBI, TBI, Total Body Irradiation, Whole Body, Whole Body Irradiation, Whole-Body Irradiation
Children's Oncology Group
Acute Lymphoblastic Leukemia, Acute Myeloid Leukemia, Mixed Phenotype Acute Leukemia, Myelodysplastic Syndrome
12/27
12/27
NCT03266627: Adenovirus-specific Cytotoxic T-lymphocytes for Refractory Adenovirus Infection

Recruiting
2
20
US
cytotoxic t-lymphocytes, viral specific CTLs
New York Medical College, Children's Hospital of Philadelphia, Medical College of Wisconsin, Nationwide Children's Hospital, Johns Hopkins University, University of California, San Francisco, University of Colorado, Denver, Indiana University, Washington University School of Medicine, University of California, Los Angeles
Adenovirus, Primary Immune Deficiency Disorder
12/25
12/26
NCT04197596: Treatment of Refractory BK Infections With Related Donor BK Specific Cytotoxic T-cells (CTLs)

Recruiting
1/2
40
US
BK CTL
New York Medical College, Children's Hospital of Philadelphia, Medical College of Wisconsin, Nationwide Children's Hospital, Johns Hopkins University, University of California, San Francisco
Viral Infection, Primary Immune Deficiency Disorder
12/24
06/25
17-CD33CART, NCT03971799: Study of Anti-CD33 Chimeric Antigen Receptor-Expressing T Cells (CD33CART) in Children and Young Adults With Relapsed/Refractory Acute Myeloid Leukemia

Recruiting
1/2
52
US
CD33CART autologous, CD33CART allogeneic
Center for International Blood and Marrow Transplant Research, National Marrow Donor Program, St. Baldrick's Foundation
Acute Myelogenous Leukemia
12/29
12/39
NCT04240808: Study of Feasibility and Safety of UCD19 Chimeric Antigen Receptor (CAR) T Cells in Adult Subjects With Relapsed/Refractory (R/R) B-Cell Non-Hodgkin's Lymphoma (B-NHL)

Active, not recruiting
1
11
US
UCD19 CAR T Cells
University of Colorado, Denver
Non Hodgkin Lymphoma
03/23
12/24
NCT01351545: A Multicenter Access and Distribution Protocol for Unlicensed Cryopreserved Cord Blood Units (CBUs)

Recruiting
N/A
99999
US
A multicenter access and distribution protocol for unlicensed cryopreserved cord blood units (CBUs)
Center for International Blood and Marrow Transplant Research, National Marrow Donor Program
Hematologic Malignancies, Inherited Disorders of Metabolism, Inherited Abnormalities of Platelets, Histiocytic Disorders, Acute Myelogenous Leukemia (AML or ANLL), Acute Lymphoblastic Leukemia (ALL), Other Acute Leukemia, Chronic Myelogenous Leukemia (CML), Myelodysplastic (MDS) / Myeloproliferative (MPN) Diseases, Other Leukemia, Hodgkin Lymphoma, Non-hodgkin Lymphoma, Multiple Myeloma/ Plasma Cell Disorder (PCD), Inherited Abnormalities of Erythrocyte Differentiation or Function, Disorders of the Immune System, Autoimmune Diseases, Severe Aplastic Anemia
10/41
10/41
Chlan, Linda
NCT02819141: Self-management of Sedative Therapy by Ventilated Patients

Active, not recruiting
2/3
190
US
Dexmedetomidine, Precedex
Mayo Clinic, University of Minnesota, National Heart, Lung, and Blood Institute (NHLBI)
Critical Illness, Anxiety, Respiratory Failure
04/24
12/24
ADS-ICU, NCT06172491: Automating Delirium Severity in the ICU

Recruiting
N/A
400
US
Mayo Clinic
Intensive Care Unit Delirium, Encephalopathy, Delirium
07/26
12/26
DDM, NCT04182334: Decreasing Delirium Through Music in Critically Ill Older Adults

Completed
N/A
160
US
Slow Tempo Music, Attention Control
Indiana University, National Institute on Aging (NIA)
Intensive Care Unit Delirium, Pain, Anxiety, Intensive Care Acquired Cognitive Impairment
12/23
04/24
Flaherty, James
NCT04472299: Paravertebral Block to Reduce the Incidence of New Onset Atrial Fibrillation After Cardiac Surgery

Recruiting
4
30
US
Ropivacaine 0.2% Injectable Solution
University of Minnesota
New Onset Atrial Fibrillation, Anesthesia, Local, Cardiac Disease
07/25
07/25
NCT06411795: Rectus Sheath Block With Liposomal Bupivacaine Versus Thoracic Epidural Analgesia for Pain Control Following Pancreatoduodenectomy

Recruiting
2
78
US
Bupivacaine, AH 250, Hydromorphone, (-)-Hydromorphone, Dihydromorphinone, Hydromorphon, Iopamidol, Isovue, Niopam, Solutrast, Liposomal Bupivacaine, Bupivacaine Liposome Injectable Suspension, Exparel, Medical Chart Review, Chart Review, Questionnaire Administration, Thoracic Epidural Analgesia, TEA, Thoracic Epidural, Ultrasound Imaging, 2-Dimensional Grayscale Ultrasound Imaging, 2-Dimensional Ultrasound Imaging, 2D-US, Ultrasonography, Ultrasound, Ultrasound Test, Ultrasound, Medical, US, X-Ray Imaging, Conventional X-Ray, Diagnostic Radiology, Medical Imaging, X-Ray, Plain film radiographs, Radiographic Imaging, Radiographic imaging procedure (procedure), Radiography, RG, Static X-Ray, X-Ray
Masonic Cancer Center, University of Minnesota, National Cancer Institute (NCI)
Duodenal Neoplasm, Pancreatic Neoplasm
01/26
01/26
CLASP IID, NCT03706833: Edwards PASCAL /IIF Pivotal Clinical Trial

Recruiting
N/A
1247
Europe, Canada, US
Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System
Edwards Lifesciences
Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation
01/25
04/30
NCT05425459: RESPONDER-HF Trial

Recruiting
N/A
750
Europe, Canada, US, RoW
Corvia Atrial Shunt System / IASD System II, Intra-cardiac echocardiography (ICE), or transesophageal echocardiography (TEE)
Corvia Medical
Heart Failure, Heart Failure, Diastolic
05/25
03/31
CorCinch-HF, NCT04331769: Clinical Evaluation of the AccuCinch® Ventricular Restoration System in Patients Who Present with Symptomatic Heart Failure with Reduced Ejection Fraction (HFrEF): the CORCINCH-HF Study

Recruiting
N/A
400
Europe, US, RoW
AccuCinch Ventricular Restoration System, Guideline-Directed Medical Therapy
Ancora Heart, Inc.
Heart Failure with Reduced Ejection Fraction (HFrEF), Dilated Cardiomyopathy
12/26
12/30
ALT-FLOW II, NCT05686317: Trial of the Edwards APTURE Transcatheter Shunt System

Recruiting
N/A
100
Europe, Canada, US
Edwards APTURE transcatheter shunt system, Sham procedure
Edwards Lifesciences
Heart Failure
01/26
07/30
TP-TAVR, NCT03826264: Transpacific TAVR Registry

Recruiting
N/A
10000
US, RoW
TAVR
Duk-Woo Park, MD, CardioVascular Research Foundation, Korea
Heart Valve Diseases, Aortic Valve Insufficiency
12/35
12/36
NCT05907564: Aventus Thrombectomy System Pulmonary Embolism Clinical Study

Recruiting
N/A
120
US
Thrombectomy
Inquis Medical, Inc.
Pulmonary Embolism, Embolism, Embolism and Thrombosis, Vascular Diseases, Cardiovascular Diseases, Lung Diseases, Respiratory Tract Diseases
03/25
03/25
AV-MDR, NCT04573660: Abbott Vascular Medical Device Registry

Recruiting
N/A
3784
Europe, US, RoW
Coronary and peripheral stents, Pacing catheters, Vascular plugs, Measurement and imaging (FFR and OCT), Peripheral dilatation catheters, Coronary dilatation catheters, Coronary and peripheral guidewires, Vessel closure/compression devices, Vascular access introducers
Abbott Medical Devices
Acute Myocardial Infarction, Restenoses, Coronary, Coronary Artery Lesions, Venous Embolism, Arterial Embolism
11/30
11/31
Sudel, Boris
NCT03115086: The REPLACE Registry for Cholbam® (Cholic Acid)

Active, not recruiting
N/A
55
US
Cholbam
Mirum Pharmaceuticals, Inc.
Bile Acid Synthesis Disorders
07/38
07/39
Schacker, Timothy W
NCT04269265: The Effect of Inflammation and Damage to Lymph Node Structures on Durable Protective Immunity Following Yellow Fever Vaccination

Active, not recruiting
1/2
43
US, RoW
Yellow Fever Vaccine, YF-VAX
University of Minnesota, National Institute of Allergy and Infectious Diseases (NIAID)
Yellow Fever
06/25
06/25
Weinert, Craig
NCT02819141: Self-management of Sedative Therapy by Ventilated Patients

Active, not recruiting
2/3
190
US
Dexmedetomidine, Precedex
Mayo Clinic, University of Minnesota, National Heart, Lung, and Blood Institute (NHLBI)
Critical Illness, Anxiety, Respiratory Failure
04/24
12/24
Arora, Mukta
NCT03870750: Identifying Best Approach in Improving Quality of Life and Survival After a Donor Stem Cell Transplant in Older, Medically Infirm, or Frail Patients With Blood Diseases

Active, not recruiting
2/3
455
US
Supportive Palliative Care, Comfort Care, palliation, palliative care, palliative therapy, Palliative Treatment, Symptom Management, Symptoms Management, PA-Palliative Therapy, Clinical Management, Best Practice, standard of care, standard therapy, Allogeneic Hematopoietic Stem Cell Transplantation, Allogeneic Hematopoietic Cell Transplantation, Allogeneic Stem Cell Transplantation, HSC, HSCT, Stem Cell Transplantation, Questionnaire Administration, Quality-of-Life Assessment, Quality of Life Assessment, Survey Administration
Fred Hutchinson Cancer Center, National Cancer Institute (NCI), National Institutes of Health (NIH)
Hematopoietic and Lymphoid Cell Neoplasm, Non-Neoplastic Hematologic and Lymphocytic Disorder
12/25
12/25
Hanson, Laura C
REACH PC, NCT03375489: Early Integrated Telehealth Versus In-Person Palliative Care for Patients With Lung Cancer

Active, not recruiting
N/A
1250
US
Telehealth, In-person PC
Massachusetts General Hospital, Patient-Centered Outcomes Research Institute, Palliative Care Research Cooperative Group
Lung Cancer
12/23
12/24
ADRD-PC, NCT04948866: Palliative Care for Persons With Late-stage Alzheimer's and Related Dementias and Their Caregivers

Active, not recruiting
N/A
474
US
ADRD-PC Program
University of North Carolina, Chapel Hill, National Institute on Aging (NIA)
Dementia, Dementia, Vascular, Dementia With Lewy Bodies, Dementia Frontal, Dementia, Mixed, Dementia Alzheimers, Alzheimer Disease, Dementia Severe
02/25
02/25
AD-ACP, NCT06565169: Improving PCP Advance Care Planning for People with ADRD

Not yet recruiting
N/A
120
US
Primary Care Team Advance Care Planning With People with Alzheimer's Disease or a Related Dementia Training, AD-ACP, Care as Usual
University of Pittsburgh, University of North Carolina, Chapel Hill, National Institute on Aging (NIA)
Alzheimer Disease, Dementia, Alzheimer's Disease (Incl Subtypes), Aging
05/27
05/27
SCOPE-L, NCT05237258: Specialty Compared to Oncology Delivered Palliative Care for Patients With Acute Myeloid Leukemia

Recruiting
N/A
2300
US
Specialty Palliative Care, Primary Palliative Care
Massachusetts General Hospital, Patient-Centered Outcomes Research Institute
Relapsed Adult AML, Primary Refractory Acute Myeloid Leukemia, High Risk Acute Myeloid Leukemia
04/28
04/29
Bellin, Melena
PROCEED, NCT04753255: Prospective Evaluation of Chronic Pancreatitis for Epidemiologic and Translational Studies, the Study

Recruiting
N/A
1820
US
Biospecimen Collection, Computed Tomography with Contrast, Contrast Enhanced Computed Tomography, CONTRAST ENHANCED CT SCAN, Contrast-enhanced Computed Tomography, CT Scan With Contrast, CT with Contrast, Contrast-enhanced Magnetic Resonance Imaging, CONTRAST ENHANCED MRI, Contrast-enhanced MRI, Dual X-ray Absorptiometry, BMD scan, bone mineral density scan, DEXA, DEXA Scan, dual energy x-ray absorptiometric scan, Dual Energy X-ray Absorptiometry, Dual X-Ray Absorptometry, DXA, DXA SCAN, Endoscopic Ultrasound, endosonography, EUS, Esophagogastroduodenoscopy, EGD, Questionnaire Administration
M.D. Anderson Cancer Center
Acute Pancreatitis, Chronic Pancreatitis
03/22
03/22
EXAX, NCT01606475: Islet Transplant for Type 1 or Surgical Diabetes

Available
N/A
US
Allogeneic islets of Langerhans, Islets
University of Minnesota
Type 1 Diabetes Mellitus, Hypoglycemia, Labile Diabetes, End-stage Renal Disease
 
 
DREAM-ON, NCT06401577: Diabetes RElated to Acute Pancreatitis and Its Mechanisms: Metabolic Outcomes Using Novel CGM Metrics

Not yet recruiting
N/A
800
US
Dexcom Continuous Glucose Monitor (CGM)
Milton S. Hershey Medical Center, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Benaroya Research Institute, Cedars-Sinai Medical Center, University of Southern California, Indiana University, Johns Hopkins University, Ohio State University, Stanford University, University of Florida, AdventHealth, University of Illinois at Chicago, Northwestern University, University of Minnesota, University of Pittsburgh
Acute Pancreatitis
12/26
03/27
DREAM, NCT05197920: Diabetes RElated to Acute Pancreatitis and Its Mechanisms

Recruiting
N/A
800
US
Milton S. Hershey Medical Center, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), Benaroya Research Institute, Cedars-Sinai Medical Center, University of Southern California, Indiana University, Johns Hopkins University, Ohio State University, Stanford University, University of Florida, AdventHealth, University of Illinois at Chicago, Northwestern University, University of Minnesota, University of Pittsburgh
Acute Pancreatitis
04/25
04/25
Smith, Angie
AUGMENT-101, NCT04065399 / 2020-004104-34: A Study of Revumenib in R/R Leukemias Including Those With an MLL/KMT2A Gene Rearrangement or NPM1 Mutation

Jan 2024 - Dec 2024: Market entry for acute leukemias
Hourglass Feb 2024 - Mar 2024 : Q1'24 - PDUFA date from FDA for R/R KMT2Ar acute leukemia
Dec 2022 - Dec 2023: Submission in US for relapsed/refractory acute leukemia
Jul 2023 - Sep 2023: Data from AUGMENT-101 trial for r/r AML
Checkmark Updated data from P1 portion of P1/2 AUGMENT-101 trial for AML
More
Recruiting
1/2
413
Europe, Canada, US, RoW
revumenib, SNDX-5613, cobicistat
Syndax Pharmaceuticals, Syndax Pharmaceuticals, Inc
Acute Myeloid Leukemia, Acute Lymphoblastic Leukemia, Mixed Lineage Acute Leukemia, Mixed Phenotype Acute Leukemia, Acute Leukemia of Ambiguous Lineage
12/27
12/27
Hohmann, Elizabeth L
STOMP, NCT05534984: Study of Tecovirimat for Human Mpox Virus

Active, not recruiting
3
719
Japan, US, RoW
Tecovirimat Oral Capsule, Placebo, Tecovirimat Oral Capsule (Open Label)
National Institute of Allergy and Infectious Diseases (NIAID), SIGA Technologies
MPOX
10/24
09/25
RESTORATiVE303, NCT06237452: VE303 for Prevention of Recurrent Clostridioides Difficile Infection

Recruiting
3
852
Europe, Canada, US, RoW
VE303, Placebo
Vedanta Biosciences, Inc.
Clostridium Difficile, Clostridium Difficile Infections, Clostridium Difficile Infection Recurrence, Clostridioides Difficile Infection, Clostridioides Difficile Infection Recurrence, CDI, C. Diff Infection, Recurrent Clostridium Difficile Infection, C.Difficile Diarrhea, Diarrhea Infectious
06/27
10/27
NCT06083142: Fecal Microbiota Transplant for Autobrewery Syndrome

Recruiting
1
8
US
Fecal microbiota transplantation capsules
Massachusetts General Hospital, National Institutes of Health (NIH)
Auto-Brewery Syndrome, Gut Fermentation Syndrome
08/29
08/30
Reding, Mark
ATHN 16, NCT04647227: SEVENFACT® for Bleeding Events in Hemophilia With Inhibitors

Recruiting
4
55
US
coagulation factor VIIa [recombinant]-jncw, SEVENFACT
American Thrombosis and Hemostasis Network, LFB USA, Inc.
Hemophilia A With Inhibitor, Hemophilia B With Inhibitor
09/26
03/27
KEYSTONE 1, NCT06297486: Study of a Gene Therapy Treatment for Hemophilia A

Withdrawn
3
85
US
SPK-8011, AAV-Spark200-BDD-hFVIII, Dirloctocogene samoparvovec
Spark Therapeutics, Inc.
Hemophilia A
05/27
09/35
NCT05695391: A Phase 3 Study of the Safety and Efficacy of Coagulation Factor VIIa (Recombinant) for the Prevention of Excessive Bleeding in Patients With Congenital Hemophilia A or B With Inhibitors to Factor VIII or IX Undergoing Elective Major Surgical Procedures SCOPE HIM

Recruiting
3
19
US, RoW
Coagulation Factor VIIa (Recombinant)
Laboratoire français de Fractionnement et de Biotechnologies
Hemophilia
06/25
07/25
PRESent-3, NCT05789537: A Study of SerpinPC in Participants with Hemophilia B (HemB) with Inhibitors

Active, not recruiting
2
3
Europe, US, RoW
SerpinPC, Activated Protein C (APC) inhibitor
ApcinteX Ltd, Centessa Pharmaceuticals plc
Hemophilia B with Inhibitor, Hemophilia B
11/24
02/25
PRESent-2, NCT05789524: The Efficacy and Safety of SerpinPC in Participants with Severe Hemophilia a or Moderately Severe to Severe Hemophilia B

Active, not recruiting
2
60
Europe, Canada, US, RoW
SerpinPC, Activated Protein C (APC) inhibitor
ApcinteX Ltd, Centessa Pharmaceuticals plc
Hemophilia a, Hemophilia B
11/24
02/25
Kline, Susan E
NCT06378359: Effectiveness of Screening and Decolonization of S. Aureus to Prevent S. Aureus Surgical Site Infections in Surgery Outpatients

Recruiting
N/A
250
US
Screening and decolonization for SA carriers with the 3 drug bundle, No screening for SA, no screening, Nasal povidone-iodine on surgery day plus 2 CHG pre-op showers without screening., Nasal alcohol gel on surgery day plus 2 CHG pre-op showers without screening
University of Minnesota
Staphylococcus Aureus Colonization, Surgical Site Infections, Healthcare Associated Infections
12/25
12/26
Elliott, Sean P
ROBUST-II, NCT03270384: Re-establishing Flow Via Drug Coated Balloon For The Treatment Of Urethral Stricture Disease

Active, not recruiting
N/A
16
US
Urotronic Drug Coated Balloon (DCB)
Urotronic Inc.
Urethral Stricture
11/19
12/24
ROBUST III, NCT03499964: - Re-Establishing Flow Via Drug Coated Balloon For The Treatment Of Urethral Stricture Disease

Active, not recruiting
N/A
127
Canada, US
Optilume Drug Coated Balloon (DCB), Control Treatment, Uncoated dilation balloon, Direct Vision Internal Urethrotomy (DVIU), Rigid Rod
Urotronic Inc., Laborie Medical Technologies Inc., NAMSA
Urethral Stricture
12/20
12/25
Thenappan, Thenappan
NCT05983250: LEVosimendan to Improve Exercise Limitation in Patients With PH-HFpEF

Recruiting
3
152
Canada, US
TNX-103, Placebo
Tenax Therapeutics, Inc., Medpace, Inc., Northwestern University
Pulmonary Hypertension
03/27
07/27
NCT04884971: Microbiota Transplant Therapy for Pulmonary Arterial Hypertension: Early Safety and Feasibility Study

Completed
1
11
US
Intestinal microbiota transplant (IMT)
University of Minnesota
Pulmonary Arterial Hypertension
12/23
12/23
NCT06481852: A Placebo-controlled, Randomized Clinical Trial to Assess the Safety, Feasibility, and Pharmacokinetics of Microbiota Transplant Therapy With Antibiotic Preconditioning and Fiber Supplementation in Patients With Pulmonary Arterial Hypertension

Recruiting
1
24
US
MTT with antibiotic preconditioning + fiber supplementation, MTT with antibiotic preconditioning + placebo supplementation, MTT with placebo + placebo supplementation.
University of Minnesota
Pulmonary Arterial Hypertension
09/26
09/26
PEX-NET, NCT03954574: Pulmonary Hemodynamics During Exercise - Research Network

Recruiting
N/A
1500
Europe, US, RoW
assessment of pulmonary hemodynamics during exercise by right heart catheterization
Medical University of Graz, European Respiratory Society
Pulmonary Circulation Diseases
12/29
12/29
ASPIRE PH, NCT04555161: Treatment of Pulmonary Arterial Hypertension Using the Aria CV Pulmonary Hypertension System

Recruiting
N/A
30
US
Aria CV Pulmonary Hypertension System, Aria CV PH System
Aria CV, Inc
Pulmonary Arterial Hypertension, Pulmonary Hypertension, Right Heart Dysfunction
10/25
10/26
PHAR, NCT04071327: Pulmonary Hypertension Association Registry

Recruiting
N/A
3000
US
Pulmonary Hypertension Association, Inc., University of Washington, the Collaborative Health Studies Coordinating Center
Pulmonary Arterial Hypertension, Chronic Thromboembolic Pulmonary Hypertension, Pulmonary Hypertension
10/25
10/25
Missov, Emil D
NCT03523416: Early Feasibility Study - Edwards APTURE Transcatheter Shunt System

Active, not recruiting
N/A
71
US
Transcatheter Atrial Shunt System
Edwards Lifesciences
Heart Failure
12/23
11/28
LUX-Dx TRENDS, NCT04790344: Evaluates Diagnostics Sensors in Heart Failure Patients Receiving Boston Scientific's Investigational ICM System.

Active, not recruiting
N/A
525
US
Investigational LUX-Dx ICM Implant
Boston Scientific Corporation
Heart Failure
05/26
06/26
Polly, David W
NCT06368245: Durability of Suppl. Rod Constructs-SuppleMentAry Rod Technique for Long-segment Posterior Instrumented Spinal Fusions

Not yet recruiting
N/A
1244
Europe, Canada, Japan, US, RoW
long-segment posterior TL instrumented fusion
AO Foundation, AO Spine
Spinal Fusion
12/27
07/29
 

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