UZ Antwerpen
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 12 Trials 
46 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Wolf, Florian
NCT06218875: Endovascular AAA Intervention Using the GORE® EXCLUDER® Conformable AAA Endoprosthesis or Iliac Branch Endoprosthesis

Recruiting
N/A
3500
Europe, US
W.L.Gore & Associates
AAA - Abdominal Aortic Aneurysm
09/42
09/42
NCT06507865: Post Market Registry for GORE® TAG® Thoracic Branch Endoprosthesis

Not yet recruiting
N/A
200
Europe
GORE® TAG® Thoracic Branch Endoprosthesis, TBE device
W.L.Gore & Associates
Aneurysm, Dissection, Aortic, TAA Thoracoabdominal Aortic Aneurysm, Thoracic Aortic Aneurysm, Transection Aorta
04/31
04/31
NCT06914648: The Dragon PLC Trial (DRAGON-PLC)

Not yet recruiting
N/A
358
Europe, Canada, RoW
Portal Vein Embolization, Hepatic Vein Embolization
Maastricht University
Primary Liver Cancer, Hepatocellular Carcinoma (HCC), Cholangiocarcinoma
11/32
11/32
Altintas, Sevilay
ELAINE 3, NCT05696626: Evaluation of Lasofoxifene Combined With Abemaciclib Compared With Fulvestrant Combined With Abemaciclib in Locally Advanced or Metastatic ER+/HER2- Breast Cancer With an ESR1 Mutation

Recruiting
3
500
Europe, Canada, US, RoW
Lasofoxifene in combination with abemaciclib, Fulvestrant in combination with abemaciclib
Sermonix Pharmaceuticals Inc.
Metastatic Breast Cancer
04/27
04/28
FLORA-4, NCT04498117 / 2020-002270-26: Oregovomab Plus Chemo in Newly Diagnosed Patients With Advanced Epithelial Ovarian Cancer Following Optimal Debulking Surgery

Active, not recruiting
3
615
Europe, Canada, US, RoW
Oregovomab, MAb-B43.13, Paclitaxel, Taxol, Carboplatin, Paraplatin, Placebo
CanariaBio Inc., Gynecologic Oncology Group, Iqvia Pty Ltd
Carcinoma, Ovarian Epithelial, Ovarian Neoplasms, Ovarian Cancer, Ovarian Serous Adenocarcinoma, Fallopian Tube Neoplasms, Fallopian Tube Adenocarcinoma, Fallopian Tube Serous Adenocarcinoma, Peritoneal Cancer, Peritoneal Carcinoma, Peritoneal Neoplasms
09/25
08/27
NCT05085002 / 2021-005238-40: A Study of Lerociclib in Participants With Advanced Breast Cancer

Terminated
2
100
Europe, US, RoW
Lerociclib + Letrozole or Fulvestrant
EQRx, Inc.
Advanced Breast Cancer
11/23
11/23
ABBICAR, NCT06365788: Bicalutamide and Abemaciclib in Inoperable or Metastatic Androgen Receptor-positive Triple-negative Breast Cancer

Recruiting
2
53
Europe
Abemaciclib, Verzenios, Bicalutamide, Bicalutamide Teva
Universitaire Ziekenhuizen KU Leuven, Kom Op Tegen Kanker, Eli Lilly and Company, Teva Pharma
Triple Negative Breast Neoplasms
12/27
12/28
LESLIE, NCT06831955: LifEStyle Intervention to Enhance Efficacy of Neoadjuvant Therapy in Patients with Triple Negative Breast Cancer

Not yet recruiting
2
356
Europe
Exercise Therapy, Fasting-Mimicking Diet, SOC
Universitaire Ziekenhuizen KU Leuven, KU Leuven, AZ Groeninge, Jessa Ziekenhuis Hasselt, UZ Gent, Belgium, UZ Antwerpen, Ziekenhuis ad Stroom, Antwerpen, Institute Gustave Roussy Paris, Universitair Ziekenhuis Brussel
Triple Negative Breast Cancer (TNBC), Early Setting
03/28
03/31
Moreels, Tom
SAMISEN-B, NCT05129449: A Clinical Study With the Medical Device PowerSpiral for Endoscopic Retrograde Cholangio-Pancreatography (ERCP)

Completed
N/A
89
Europe
Endoscopic Retrograde Cholangio-Pancreatography (ERCP)
Olympus Europe SE & Co. KG
Cholangiopancreatography, Endoscopic Retrograde
06/23
06/23
NCT06174805: AXIOS™ Gastroenterostomy for Gastric Outlet Obstruction IDE

Recruiting
N/A
67
Europe, Canada, US, RoW
AXIOS(TM) Stent and Electrocautery Enhanced Delivery System
Boston Scientific Corporation
Gastric Outlet Obstruction
02/27
03/27
Jorens, Philippe
TGC-fast, NCT03665207 / 2018-000756-17: Tight Versus Liberal Blood Glucose Control in Adult Critically Ill Patients

Active, not recruiting
3
9230
Europe
Insulin
KU Leuven, Universitaire Ziekenhuizen KU Leuven, Research Foundation Flanders
Critical Illness, Hyperglycemia
11/22
11/26
REMAP-CAP, NCT02735707 / 2015-002340-14: Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia

Recruiting
3
20000
Europe, Canada, Japan, US, RoW
Ceftriaxone, Moxifloxacin or Levofloxacin, Piperacillin-tazobactam, Ceftaroline, Amoxicillin-clavulanate, Standard course macrolide, Extended course macrolide, No systemic corticosteroid, Fixed-duration Hydrocortisone, Shock-dependent hydrocortisone, Fixed-duration higher dose Hydrocortisone, No antiviral agent for influenza, Five-days oseltamivir, Ten-days oseltamivir, No antiviral agent for COVID-19, Lopinavir / Ritonavir, Hydroxychloroquine, Hydroxychloroquine + lopinavir/ritonavir, Ivermectin, No immune modulation for COVID-19, Interferon beta-1a, IFN-β1a, Anakinra, Tocilizumab, Sarilumab, Local standard venous thromboprophylaxis, Therapeutic dose anticoagulation, Conventional low dose thromboprophylaxis, Intermediate dose thromboprophylaxis, Continuation of therapeutic dose anticoagulation, No immunoglobulin, Convalescent plasma, Delayed administration of convalescent plasma, No vitamin C, Vitamin C, No antiplatelet, Aspirin, acetylsalicylic acid, P2Y12 inhibitor, Clopidogrel, Prasugrel, Ticagrelor, No simvastatin, Simvastatin, Eritoran, Apremilast, Clinician-preferred mechanical ventilation strategy, Protocolised mechanical ventilation strategy, No renin-angiotensin system inhibitor, Angiotensin converting enzyme inhibitor, Ramipril, Lisinopril, Perindopril, Enalapril, Trandolapril, Captopril, Angiotensin Receptor Blockers, Losartan, Valsartan, Candesartan, Irbesartan, Telmisartan, Olmesartan, ARB + DMX-200, No cysteamine, Cysteamine, Fixed-duration dexamethasone, Baloxavir Marboxil, Five-days oseltamivir + baloxavir marboxil, Ten-days oseltamivir + baloxavir marboxil, No endothelial modulator, Imatinib, No Immune Modulator for Influenza, Baricitinib, Nirmatrelvir/ritonavir, Paxlovid, Remdesivir, Nirmatrelvir/ritonavir + remdesivir
UMC Utrecht, Australian and New Zealand Intensive Care Research Centre, Medical Research Institute of New Zealand, Unity Health, Berry Consultants, Global Coalition for Adaptive Research, University of Pittsburgh Medical Center, Intensive Care National Audit & Research Centre, St. Marianna University School of Medicine, Nat Intensive Care Surveillance - MORU, National University Hospital, Singapore
Community-acquired Pneumonia, Influenza, COVID-19
02/26
02/28
NCT02916004: The Use of Nociception Flexion Reflex and Pupillary Dilatation Reflex in ICU Patients.

Completed
N/A
40
Europe
Measurement of NFR and PDR
University Hospital, Antwerp
Critical Illness
11/17
07/18
PLASTIC-NICU, NCT05404815: Exposure to Plasticisers in the Neonatal Intensive Care Unit

Completed
N/A
132
Europe
University Hospital, Antwerp, Research Foundation Flanders, Universiteit Antwerpen
Preterm Birth, Premature Birth, Neurodevelopmental Disorders, Pulmonary Disease, Bronchopulmonary Dysplasia, Harm Reduction, Environmental Exposure, Development, Infant
12/23
12/23
ICU-FERRO, NCT06928649: Stratifying Critically Ill Patients for Novel Ferroptosis or Pyroptosis Intervention Strategies

Recruiting
N/A
600
Europe
Blood sampling, Urine sampling, Bronchoalveolar lavage sampling, Cerebrospinal fluid sampling
University Hospital, Antwerp, Universiteit Antwerpen
Sepsis, Trauma Related Injuries, Subarachnoid Haemorrhage (SAH)
08/26
08/26
VIREM, NCT05459116: Visualization of Inspiratory Effort and Respiratory Mechanics to Promote Lung- and Diaphragm Protective Ventilation

Recruiting
N/A
150
Europe, Canada
Placement of nasogastric balloon
University Hospital, Antwerp, Research Foundation Flanders, Universitaire Ziekenhuizen KU Leuven, The Hospital for Sick Children, University of Toronto, Universiteit Antwerpen, KU Leuven
Respiratory Muscles, Respiration, Artificial, Respiratory Function Tests
06/25
12/25
MMUSCLE, NCT06345547: Muscle Mass Via UltraSound in Cirrhosis

Recruiting
N/A
60
Europe
ultrasound, hand grip strength
University Hospital, Antwerp
Sarcopenia, Cirrhosis, Malnutrition
08/26
09/27
DeXFLoW, NCT06024993: Dead Space in Mechanical Ventilation With Constant Expiratory Flow

Not yet recruiting
N/A
13
Europe
Flow-controlled ventilation (FCV), Conventional volume-controlled ventilation (VCV)
University Hospital, Antwerp, Universiteit Antwerpen
Mechanical Ventilation, Artificial Respiration
11/24
12/24
TONES, NCT05380687: Time Course of Neuro-ventilatory Efficiency During a Spontaneous Breathing Training

Completed
N/A
1
Europe
Inspiratory hold, Expiratory hold, Ultrasound of respiratory muscles, PEEP 10, PEEP 5, PEEP 0
University Hospital, Antwerp, Research Foundation Flanders
Ventilator Weaning, Respiration, Artificial, Respiratory Muscles, Respiratory Failure, Critical Care
12/23
12/23
Sabato, Vito
HARBOR, NCT04910685 / 2020-005173-28: () Study to Evaluate Efficacy and Safety of BLU-263 Versus Placebo in Patients With Indolent Systemic Mastocytosis

Recruiting
2/3
463
Europe, US, RoW
Elenestinib, BLU-263, Placebo
Blueprint Medicines Corporation
Indolent Systemic Mastocytosis, Monoclonal Mast Cell Activation Syndrome, Smoldering Systemic Mastocytosis
06/28
06/28
FEBRIS, NCT05670301: Flemish Joint Effort for Biomarker PRofiling in Inflammatory Systemic Diseases

Recruiting
N/A
2500
Europe
cytokine and lipidomic profiling
University Hospital, Ghent, University Hospital, Antwerp, Ziekenhuis Netwerk Antwerpen (ZNA), Universitair Ziekenhuis Brussel, Jessa Hospital, Hasselt University
Autoinflammatory Disease, Autoimmune Diseases, Inflammation
12/29
12/29
Vandamme, Timon
SAUNA, NCT05701241: Continuing Somatostatin Analogues Upon Progression in Neuroendocrine Tumour pAtients

Recruiting
4
270
Europe
Somatostatin analog, lanreotide, octreotide, sandostatin, somatuline
University Hospital, Antwerp, Erasmus Medical Center, ZonMw: The Netherlands Organisation for Health Research and Development, Belgium Health Care Knowledge Centre
Gastroenteropancreatic Neuroendocrine Tumor
04/29
04/34
BALLAD, NCT04257461: A Trial to Evaluate the Potential Benefit of Adjuvant Chemotherapy for Small Bowel Adenocarcinoma

Active, not recruiting
3
30
Europe
Fluoropyrimidine, Capecitabine, LV5FU2, Oxaliplatin, Xeloda
Belgian Group of Digestive Oncology, Kom Op Tegen Kanker, Cancer Research UK
Small Bowel Adenocarcinoma
12/25
12/25
SAFIR-ABC10, NCT05615818: Personalized Medicine for Advanced Biliary Cancer Patients

Recruiting
3
800
Europe
Futibatinib, Ivosidenib, Tibsovo, Zanidatamab, Trastuzumab, Zercepac, Neratinib, Nerlynx, Encorafenib, Braftovi, Binimetinib, Mektovi, Niraparib, Zejula, Cisplatin, Gemcitabine
UNICANCER, Cancer Research UK & UCL Cancer Trials Centre, Belgian Group of Digestive Oncology, National Cancer Institute, France, Cancer Research UK, Taiho Oncology, Inc., Servier, Zymeworks BC Inc., Accord Healthcare, Inc., Pierre Fabre Medicament
Biliary Tract Neoplasms
06/27
06/28
Actuate 1801, NCT03678883 / 2018-003739-32: 9-ING-41 in Patients with Advanced Cancers

Active, not recruiting
2
350
Europe, Canada, US
9-ING-41, Gemcitabine - 21 day cycle, Gemzar, Doxorubicin., Doxil, Adriamycin, Lomustine, CCNU, Gleostine, Carboplatin., Paraplatin, Nab paclitaxel., Abraxane, Protein-bound paclitaxel, Nanoparticle albumin-bound paclitaxel, Paclitaxel., Taxol, Gemcitabine - 28 day cycle, Irinotecan, Camptosar
Actuate Therapeutics Inc., Actuate Therapeutics Inc
Cancer, Pancreatic Cancer, Sarcoma, Renal Cancer, Refractory Cancer, Refractory Neoplasm, Refractory Non-Hodgkin Lymphoma, Pancreatic Adenocarcinoma, Resistant Cancer, Neoplasm Metastasis, Neoplasm of Bone, Neoplasm, Breast, Neoplasm of Lung, Neoplasms,Colorectal, Neoplasms Pancreatic, Malignant Glioma, Malignancies, Malignancies Multiple, Bone Metastases, Bone Neoplasm, Bone Cancer, Pancreas Cancer, Pancreatic Neoplasms, Breast Neoplasms, Acute T Cell Leukemia Lymphoma
01/25
01/26
NALPAC, NCT05472259 / 2020-003889-39: A Study Evaluating the Efficacy of 5-FU + NALIRI and 5-FU + NALIRINOX for PDAC

Recruiting
2
134
Europe
Nanoliposomal irinotecan, Onyvide, 5 FU, Fluorouracil, Leucovorin, Folinate, Elvorine, Oxaliplatin
Belgian Group of Digestive Oncology, University Hospital St Luc, Brussels
Metastatic Pancreatic Ductal Adenocarcinoma
12/26
12/27
STEREOPAC, NCT05083247: Preoperative mFOLFIRINOX (or Gem-Nab-P) +/- Isotoxic High-dose SBRT for Borderline Resectable Pancreatic Adenocarcinoma

Recruiting
2
256
Europe
mFOLFIRINOX or Gemcitabine nab-paclitaxel, mFFX or Gem/Nab-p, Isotoxic High-Dose (iHD)-SBRT, Surgery
Erasme University Hospital, Jules Bordet Institute, Belgian Group of Digestive Oncology, University Hospital St Luc, Brussels
Pancreatic Neoplasm, Pancreatic Adenocarcinoma, Borderline Resectable Pancreatic Adenocarcinoma
12/27
12/30
IL15-TransDC, NCT05964361: First-in-human Interleukin-15-transpresenting Wilms' Tumor Protein 1-targeting Autologous Dendritic Cell Vaccination in Cancer Patients

Recruiting
1/2
10
Europe
IL15-transpresenting WT1-targeted Dendritic Cell Vaccine, IL15/IL15Ra/WT1 DC vaccine, IL15-transpresenting WT1-targeting DC vaccine
University Hospital, Antwerp, Kom Op Tegen Kanker, Stichting tegen Kanker
Esophageal Cancer, Pancreas Cancer, Ovarian Cancer, Liver Cancer
04/25
09/25
BE-FORCE, NCT06541080: Collection of Liquid Biopsy Samples of Neuroendocrine Neoplasms (NEN) Patients - Collection of NET (CollectNET) 2.0, a Study by the Consortium

Recruiting
N/A
550
Europe
Shallow Whole Genome Sequencing (sWGS)-GIPXplore, methylation-sensitive restriction enzymes (MSRE)-Single-molecule molecular inversion probes (smMIP)-seq assay
University Hospital, Antwerp, Universitaire Ziekenhuizen KU Leuven, Universiteit Antwerpen, KU Leuven
Neuroendocrine Neoplasms
12/28
12/30
TORPEDO, NCT06691425: Stereotactic Body Radiation Therapy for Inoperable Non-metastasized Pancreatic Adenocarcinoma

Recruiting
N/A
160
Europe
Stereotactic Body Radiation Therapy (SBRT), Chemotherapy
Cancer Research Antwerp, Kom Op Tegen Kanker, Naslund Medical AB, Varian Medical Systems
Non-metastasized Unresectable Pancreatic Carcinoma
07/30
07/30
eCAN, NCT06007001: Telerehabilitation and Tele-psychological Support in Cancer Patients JA

Recruiting
N/A
354
Europe, RoW
Telemedicine
Sciensano, European Commission
Cancer
09/24
09/24
NCT05268952: A Study to Evaluate the Value of Circulating Tumour DNA in Follow-up of Patients With an Advanced Gastroenteropancreatic or Lung Neuroendocrine Tumour Under Everolimus +- SSA Treatment (Liquid-NET 2.0)

Recruiting
N/A
100
Europe, RoW
Liquid biopsies, Scans (CT, gallium-68 DOTATE/TOC/NOC PET-CT)
University Hospital, Antwerp, Universiteit Antwerpen
Neuroendocrine Tumors
05/25
12/25
NCT05704530: Liquid Biopsies in Esophageal Cancer

Recruiting
N/A
248
Europe
Blood sample
Universitaire Ziekenhuizen KU Leuven, Kom Op Tegen Kanker
Esophageal Cancer
09/25
12/26
COPERNIC, NCT05487248: A Study of On-treatment CtDNA Changes in Chemo-refractory Colorectal Cancer Patients

Recruiting
N/A
103
Europe
Blood Sample Collection
Jules Bordet Institute, Hoffmann-La Roche
Unresectable Locally Advanced Colorectal Cancer, Metastatic Colorectal Cancer, Candidate for Third-line or Subsequent Lines of Therapy
04/26
12/26
SHAPERS, NCT06052332: Efficacy and Safety of SCRT Versus TNT in Older Patients With Locally Advanced Rectal Cancer

Recruiting
N/A
230
Europe
Short course radiotherapy, Adjuvant chemotherapy (optional), Total mesorectal excision, Total neoadjuvant therapy
Jules Bordet Institute
Locally Advanced Rectal Cancer, Older People
12/29
12/33
Quali-NET, NCT05268783: Patient-reported Outcomes in Neuroendocrine Neoplasms: a Prospective Quality of Life and Quality of Care Study Within NETwerk

Recruiting
N/A
1000
Europe
EORTC QLQ-C30, EORTC QLQ-GI.NET21, Satisfaction survey
University Hospital, Antwerp
Quality of Life
12/29
12/29
Ogunjimi, Benson
AIDA, NCT05200715: AutoInflammatory Disease Alliance Registry

Recruiting
N/A
3500
Europe, US, RoW
No intervention is foreseen by the protocol.
University of Siena
Hereditary Autoinflammatory Diseases, Schnitzler Syndrome, Behcet Syndrome, PFAPA Syndrome, Still Disease, Autoinflammatory Syndrome, Unspecified, Uveitis, Scleritis, Vexas Syndrome
08/23
08/30
FEBRIS, NCT05670301: Flemish Joint Effort for Biomarker PRofiling in Inflammatory Systemic Diseases

Recruiting
N/A
2500
Europe
cytokine and lipidomic profiling
University Hospital, Ghent, University Hospital, Antwerp, Ziekenhuis Netwerk Antwerpen (ZNA), Universitair Ziekenhuis Brussel, Jessa Hospital, Hasselt University
Autoinflammatory Disease, Autoimmune Diseases, Inflammation
12/29
12/29
Holvoet, Liesbeth
NALPAC, NCT05472259 / 2020-003889-39: A Study Evaluating the Efficacy of 5-FU + NALIRI and 5-FU + NALIRINOX for PDAC

Recruiting
2
134
Europe
Nanoliposomal irinotecan, Onyvide, 5 FU, Fluorouracil, Leucovorin, Folinate, Elvorine, Oxaliplatin
Belgian Group of Digestive Oncology, University Hospital St Luc, Brussels
Metastatic Pancreatic Ductal Adenocarcinoma
12/26
12/27
Wouters, Sanne
NALPAC, NCT05472259 / 2020-003889-39: A Study Evaluating the Efficacy of 5-FU + NALIRI and 5-FU + NALIRINOX for PDAC

Recruiting
2
134
Europe
Nanoliposomal irinotecan, Onyvide, 5 FU, Fluorouracil, Leucovorin, Folinate, Elvorine, Oxaliplatin
Belgian Group of Digestive Oncology, University Hospital St Luc, Brussels
Metastatic Pancreatic Ductal Adenocarcinoma
12/26
12/27
CAVACI, NCT05699915: Extensive CArdioVAscular Characterization and Follow-up of Patients Receiving Immune Checkpoint Inhibitors

Terminated
N/A
105
Europe
Cardiology consultation, Chest Computed Tomography (CT) without contrast, Cardiac CT, Non-invasive endothelial function tests, Flow mediated dilatation (FMD), Peripheral arterial tonometry (PAT), Electrocardiogram, ECG, Extra serum sample (7.5 mL)
Algemeen Ziekenhuis Maria Middelares
Cancer, Immune-related Adverse Event, Cardiac Abnormalities, Variable, Immune Checkpoint Inhibitor-Related Myocarditis, Diastolic Dysfunction, Atherosclerosis, Cardiotoxicity
07/24
07/24
Guerti, Khadija
FEBRIS, NCT05670301: Flemish Joint Effort for Biomarker PRofiling in Inflammatory Systemic Diseases

Recruiting
N/A
2500
Europe
cytokine and lipidomic profiling
University Hospital, Ghent, University Hospital, Antwerp, Ziekenhuis Netwerk Antwerpen (ZNA), Universitair Ziekenhuis Brussel, Jessa Hospital, Hasselt University
Autoinflammatory Disease, Autoimmune Diseases, Inflammation
12/29
12/29
Komen, Nikolaas
NCT04940611: A Study of Surgical Interventions in Fistulizing Conditions

Active, not recruiting
N/A
750
Europe, Canada, US, RoW
Takeda
Crohns Disease, Fistula, Rectovaginal Fistula, Complex Perianal Fistula, Complex Cryptoglandular Fistula
05/26
05/26
Beysen, Diane
NCT04833894 / 2020-005841-18: Evaluating the Pharmacokinetics, Pharmacodynamics, and Safety of Efgartigimod Administered Intravenously in Children with Generalized Myasthenia Gravis

Recruiting
2/3
12
Europe, Canada, US, RoW
Efgartigimod IV
argenx
Generalized Myasthenia Gravis
03/27
03/27
NCT05374590 / 2021-002460-46: Evaluating Long-term Safety of Efgartigimod Administered Intravenously and Efgartigimod PH20 Administered Subcutaneously in Children with Generalized Myasthenia Gravis

Enrolling by invitation
2/3
12
Europe, US
Efgartigimod IV or Efgartigimod PH20 SC
argenx
Generalized Myasthenia Gravis
09/28
09/28
Geert, Anja
DHELIVER, NCT04229901: Study to Evaluate the Efficacy and Safety of HepaStem in Patients With Acute on Chronic Liver Failure (ACLF)

Terminated
2
133
Europe, RoW
HepaStem, Placebo
Cellaion SA
Acute on Chronic Liver Failure
05/24
05/24
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Wolf, Florian
NCT06218875: Endovascular AAA Intervention Using the GORE® EXCLUDER® Conformable AAA Endoprosthesis or Iliac Branch Endoprosthesis

Recruiting
N/A
3500
Europe, US
W.L.Gore & Associates
AAA - Abdominal Aortic Aneurysm
09/42
09/42
NCT06507865: Post Market Registry for GORE® TAG® Thoracic Branch Endoprosthesis

Not yet recruiting
N/A
200
Europe
GORE® TAG® Thoracic Branch Endoprosthesis, TBE device
W.L.Gore & Associates
Aneurysm, Dissection, Aortic, TAA Thoracoabdominal Aortic Aneurysm, Thoracic Aortic Aneurysm, Transection Aorta
04/31
04/31
NCT06914648: The Dragon PLC Trial (DRAGON-PLC)

Not yet recruiting
N/A
358
Europe, Canada, RoW
Portal Vein Embolization, Hepatic Vein Embolization
Maastricht University
Primary Liver Cancer, Hepatocellular Carcinoma (HCC), Cholangiocarcinoma
11/32
11/32
Altintas, Sevilay
ELAINE 3, NCT05696626: Evaluation of Lasofoxifene Combined With Abemaciclib Compared With Fulvestrant Combined With Abemaciclib in Locally Advanced or Metastatic ER+/HER2- Breast Cancer With an ESR1 Mutation

Recruiting
3
500
Europe, Canada, US, RoW
Lasofoxifene in combination with abemaciclib, Fulvestrant in combination with abemaciclib
Sermonix Pharmaceuticals Inc.
Metastatic Breast Cancer
04/27
04/28
FLORA-4, NCT04498117 / 2020-002270-26: Oregovomab Plus Chemo in Newly Diagnosed Patients With Advanced Epithelial Ovarian Cancer Following Optimal Debulking Surgery

Active, not recruiting
3
615
Europe, Canada, US, RoW
Oregovomab, MAb-B43.13, Paclitaxel, Taxol, Carboplatin, Paraplatin, Placebo
CanariaBio Inc., Gynecologic Oncology Group, Iqvia Pty Ltd
Carcinoma, Ovarian Epithelial, Ovarian Neoplasms, Ovarian Cancer, Ovarian Serous Adenocarcinoma, Fallopian Tube Neoplasms, Fallopian Tube Adenocarcinoma, Fallopian Tube Serous Adenocarcinoma, Peritoneal Cancer, Peritoneal Carcinoma, Peritoneal Neoplasms
09/25
08/27
NCT05085002 / 2021-005238-40: A Study of Lerociclib in Participants With Advanced Breast Cancer

Terminated
2
100
Europe, US, RoW
Lerociclib + Letrozole or Fulvestrant
EQRx, Inc.
Advanced Breast Cancer
11/23
11/23
ABBICAR, NCT06365788: Bicalutamide and Abemaciclib in Inoperable or Metastatic Androgen Receptor-positive Triple-negative Breast Cancer

Recruiting
2
53
Europe
Abemaciclib, Verzenios, Bicalutamide, Bicalutamide Teva
Universitaire Ziekenhuizen KU Leuven, Kom Op Tegen Kanker, Eli Lilly and Company, Teva Pharma
Triple Negative Breast Neoplasms
12/27
12/28
LESLIE, NCT06831955: LifEStyle Intervention to Enhance Efficacy of Neoadjuvant Therapy in Patients with Triple Negative Breast Cancer

Not yet recruiting
2
356
Europe
Exercise Therapy, Fasting-Mimicking Diet, SOC
Universitaire Ziekenhuizen KU Leuven, KU Leuven, AZ Groeninge, Jessa Ziekenhuis Hasselt, UZ Gent, Belgium, UZ Antwerpen, Ziekenhuis ad Stroom, Antwerpen, Institute Gustave Roussy Paris, Universitair Ziekenhuis Brussel
Triple Negative Breast Cancer (TNBC), Early Setting
03/28
03/31
Moreels, Tom
SAMISEN-B, NCT05129449: A Clinical Study With the Medical Device PowerSpiral for Endoscopic Retrograde Cholangio-Pancreatography (ERCP)

Completed
N/A
89
Europe
Endoscopic Retrograde Cholangio-Pancreatography (ERCP)
Olympus Europe SE & Co. KG
Cholangiopancreatography, Endoscopic Retrograde
06/23
06/23
NCT06174805: AXIOS™ Gastroenterostomy for Gastric Outlet Obstruction IDE

Recruiting
N/A
67
Europe, Canada, US, RoW
AXIOS(TM) Stent and Electrocautery Enhanced Delivery System
Boston Scientific Corporation
Gastric Outlet Obstruction
02/27
03/27
Jorens, Philippe
TGC-fast, NCT03665207 / 2018-000756-17: Tight Versus Liberal Blood Glucose Control in Adult Critically Ill Patients

Active, not recruiting
3
9230
Europe
Insulin
KU Leuven, Universitaire Ziekenhuizen KU Leuven, Research Foundation Flanders
Critical Illness, Hyperglycemia
11/22
11/26
REMAP-CAP, NCT02735707 / 2015-002340-14: Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community- Acquired Pneumonia

Recruiting
3
20000
Europe, Canada, Japan, US, RoW
Ceftriaxone, Moxifloxacin or Levofloxacin, Piperacillin-tazobactam, Ceftaroline, Amoxicillin-clavulanate, Standard course macrolide, Extended course macrolide, No systemic corticosteroid, Fixed-duration Hydrocortisone, Shock-dependent hydrocortisone, Fixed-duration higher dose Hydrocortisone, No antiviral agent for influenza, Five-days oseltamivir, Ten-days oseltamivir, No antiviral agent for COVID-19, Lopinavir / Ritonavir, Hydroxychloroquine, Hydroxychloroquine + lopinavir/ritonavir, Ivermectin, No immune modulation for COVID-19, Interferon beta-1a, IFN-β1a, Anakinra, Tocilizumab, Sarilumab, Local standard venous thromboprophylaxis, Therapeutic dose anticoagulation, Conventional low dose thromboprophylaxis, Intermediate dose thromboprophylaxis, Continuation of therapeutic dose anticoagulation, No immunoglobulin, Convalescent plasma, Delayed administration of convalescent plasma, No vitamin C, Vitamin C, No antiplatelet, Aspirin, acetylsalicylic acid, P2Y12 inhibitor, Clopidogrel, Prasugrel, Ticagrelor, No simvastatin, Simvastatin, Eritoran, Apremilast, Clinician-preferred mechanical ventilation strategy, Protocolised mechanical ventilation strategy, No renin-angiotensin system inhibitor, Angiotensin converting enzyme inhibitor, Ramipril, Lisinopril, Perindopril, Enalapril, Trandolapril, Captopril, Angiotensin Receptor Blockers, Losartan, Valsartan, Candesartan, Irbesartan, Telmisartan, Olmesartan, ARB + DMX-200, No cysteamine, Cysteamine, Fixed-duration dexamethasone, Baloxavir Marboxil, Five-days oseltamivir + baloxavir marboxil, Ten-days oseltamivir + baloxavir marboxil, No endothelial modulator, Imatinib, No Immune Modulator for Influenza, Baricitinib, Nirmatrelvir/ritonavir, Paxlovid, Remdesivir, Nirmatrelvir/ritonavir + remdesivir
UMC Utrecht, Australian and New Zealand Intensive Care Research Centre, Medical Research Institute of New Zealand, Unity Health, Berry Consultants, Global Coalition for Adaptive Research, University of Pittsburgh Medical Center, Intensive Care National Audit & Research Centre, St. Marianna University School of Medicine, Nat Intensive Care Surveillance - MORU, National University Hospital, Singapore
Community-acquired Pneumonia, Influenza, COVID-19
02/26
02/28
NCT02916004: The Use of Nociception Flexion Reflex and Pupillary Dilatation Reflex in ICU Patients.

Completed
N/A
40
Europe
Measurement of NFR and PDR
University Hospital, Antwerp
Critical Illness
11/17
07/18
PLASTIC-NICU, NCT05404815: Exposure to Plasticisers in the Neonatal Intensive Care Unit

Completed
N/A
132
Europe
University Hospital, Antwerp, Research Foundation Flanders, Universiteit Antwerpen
Preterm Birth, Premature Birth, Neurodevelopmental Disorders, Pulmonary Disease, Bronchopulmonary Dysplasia, Harm Reduction, Environmental Exposure, Development, Infant
12/23
12/23
ICU-FERRO, NCT06928649: Stratifying Critically Ill Patients for Novel Ferroptosis or Pyroptosis Intervention Strategies

Recruiting
N/A
600
Europe
Blood sampling, Urine sampling, Bronchoalveolar lavage sampling, Cerebrospinal fluid sampling
University Hospital, Antwerp, Universiteit Antwerpen
Sepsis, Trauma Related Injuries, Subarachnoid Haemorrhage (SAH)
08/26
08/26
VIREM, NCT05459116: Visualization of Inspiratory Effort and Respiratory Mechanics to Promote Lung- and Diaphragm Protective Ventilation

Recruiting
N/A
150
Europe, Canada
Placement of nasogastric balloon
University Hospital, Antwerp, Research Foundation Flanders, Universitaire Ziekenhuizen KU Leuven, The Hospital for Sick Children, University of Toronto, Universiteit Antwerpen, KU Leuven
Respiratory Muscles, Respiration, Artificial, Respiratory Function Tests
06/25
12/25
MMUSCLE, NCT06345547: Muscle Mass Via UltraSound in Cirrhosis

Recruiting
N/A
60
Europe
ultrasound, hand grip strength
University Hospital, Antwerp
Sarcopenia, Cirrhosis, Malnutrition
08/26
09/27
DeXFLoW, NCT06024993: Dead Space in Mechanical Ventilation With Constant Expiratory Flow

Not yet recruiting
N/A
13
Europe
Flow-controlled ventilation (FCV), Conventional volume-controlled ventilation (VCV)
University Hospital, Antwerp, Universiteit Antwerpen
Mechanical Ventilation, Artificial Respiration
11/24
12/24
TONES, NCT05380687: Time Course of Neuro-ventilatory Efficiency During a Spontaneous Breathing Training

Completed
N/A
1
Europe
Inspiratory hold, Expiratory hold, Ultrasound of respiratory muscles, PEEP 10, PEEP 5, PEEP 0
University Hospital, Antwerp, Research Foundation Flanders
Ventilator Weaning, Respiration, Artificial, Respiratory Muscles, Respiratory Failure, Critical Care
12/23
12/23
Sabato, Vito
HARBOR, NCT04910685 / 2020-005173-28: () Study to Evaluate Efficacy and Safety of BLU-263 Versus Placebo in Patients With Indolent Systemic Mastocytosis

Recruiting
2/3
463
Europe, US, RoW
Elenestinib, BLU-263, Placebo
Blueprint Medicines Corporation
Indolent Systemic Mastocytosis, Monoclonal Mast Cell Activation Syndrome, Smoldering Systemic Mastocytosis
06/28
06/28
FEBRIS, NCT05670301: Flemish Joint Effort for Biomarker PRofiling in Inflammatory Systemic Diseases

Recruiting
N/A
2500
Europe
cytokine and lipidomic profiling
University Hospital, Ghent, University Hospital, Antwerp, Ziekenhuis Netwerk Antwerpen (ZNA), Universitair Ziekenhuis Brussel, Jessa Hospital, Hasselt University
Autoinflammatory Disease, Autoimmune Diseases, Inflammation
12/29
12/29
Vandamme, Timon
SAUNA, NCT05701241: Continuing Somatostatin Analogues Upon Progression in Neuroendocrine Tumour pAtients

Recruiting
4
270
Europe
Somatostatin analog, lanreotide, octreotide, sandostatin, somatuline
University Hospital, Antwerp, Erasmus Medical Center, ZonMw: The Netherlands Organisation for Health Research and Development, Belgium Health Care Knowledge Centre
Gastroenteropancreatic Neuroendocrine Tumor
04/29
04/34
BALLAD, NCT04257461: A Trial to Evaluate the Potential Benefit of Adjuvant Chemotherapy for Small Bowel Adenocarcinoma

Active, not recruiting
3
30
Europe
Fluoropyrimidine, Capecitabine, LV5FU2, Oxaliplatin, Xeloda
Belgian Group of Digestive Oncology, Kom Op Tegen Kanker, Cancer Research UK
Small Bowel Adenocarcinoma
12/25
12/25
SAFIR-ABC10, NCT05615818: Personalized Medicine for Advanced Biliary Cancer Patients

Recruiting
3
800
Europe
Futibatinib, Ivosidenib, Tibsovo, Zanidatamab, Trastuzumab, Zercepac, Neratinib, Nerlynx, Encorafenib, Braftovi, Binimetinib, Mektovi, Niraparib, Zejula, Cisplatin, Gemcitabine
UNICANCER, Cancer Research UK & UCL Cancer Trials Centre, Belgian Group of Digestive Oncology, National Cancer Institute, France, Cancer Research UK, Taiho Oncology, Inc., Servier, Zymeworks BC Inc., Accord Healthcare, Inc., Pierre Fabre Medicament
Biliary Tract Neoplasms
06/27
06/28
Actuate 1801, NCT03678883 / 2018-003739-32: 9-ING-41 in Patients with Advanced Cancers

Active, not recruiting
2
350
Europe, Canada, US
9-ING-41, Gemcitabine - 21 day cycle, Gemzar, Doxorubicin., Doxil, Adriamycin, Lomustine, CCNU, Gleostine, Carboplatin., Paraplatin, Nab paclitaxel., Abraxane, Protein-bound paclitaxel, Nanoparticle albumin-bound paclitaxel, Paclitaxel., Taxol, Gemcitabine - 28 day cycle, Irinotecan, Camptosar
Actuate Therapeutics Inc., Actuate Therapeutics Inc
Cancer, Pancreatic Cancer, Sarcoma, Renal Cancer, Refractory Cancer, Refractory Neoplasm, Refractory Non-Hodgkin Lymphoma, Pancreatic Adenocarcinoma, Resistant Cancer, Neoplasm Metastasis, Neoplasm of Bone, Neoplasm, Breast, Neoplasm of Lung, Neoplasms,Colorectal, Neoplasms Pancreatic, Malignant Glioma, Malignancies, Malignancies Multiple, Bone Metastases, Bone Neoplasm, Bone Cancer, Pancreas Cancer, Pancreatic Neoplasms, Breast Neoplasms, Acute T Cell Leukemia Lymphoma
01/25
01/26
NALPAC, NCT05472259 / 2020-003889-39: A Study Evaluating the Efficacy of 5-FU + NALIRI and 5-FU + NALIRINOX for PDAC

Recruiting
2
134
Europe
Nanoliposomal irinotecan, Onyvide, 5 FU, Fluorouracil, Leucovorin, Folinate, Elvorine, Oxaliplatin
Belgian Group of Digestive Oncology, University Hospital St Luc, Brussels
Metastatic Pancreatic Ductal Adenocarcinoma
12/26
12/27
STEREOPAC, NCT05083247: Preoperative mFOLFIRINOX (or Gem-Nab-P) +/- Isotoxic High-dose SBRT for Borderline Resectable Pancreatic Adenocarcinoma

Recruiting
2
256
Europe
mFOLFIRINOX or Gemcitabine nab-paclitaxel, mFFX or Gem/Nab-p, Isotoxic High-Dose (iHD)-SBRT, Surgery
Erasme University Hospital, Jules Bordet Institute, Belgian Group of Digestive Oncology, University Hospital St Luc, Brussels
Pancreatic Neoplasm, Pancreatic Adenocarcinoma, Borderline Resectable Pancreatic Adenocarcinoma
12/27
12/30
IL15-TransDC, NCT05964361: First-in-human Interleukin-15-transpresenting Wilms' Tumor Protein 1-targeting Autologous Dendritic Cell Vaccination in Cancer Patients

Recruiting
1/2
10
Europe
IL15-transpresenting WT1-targeted Dendritic Cell Vaccine, IL15/IL15Ra/WT1 DC vaccine, IL15-transpresenting WT1-targeting DC vaccine
University Hospital, Antwerp, Kom Op Tegen Kanker, Stichting tegen Kanker
Esophageal Cancer, Pancreas Cancer, Ovarian Cancer, Liver Cancer
04/25
09/25
BE-FORCE, NCT06541080: Collection of Liquid Biopsy Samples of Neuroendocrine Neoplasms (NEN) Patients - Collection of NET (CollectNET) 2.0, a Study by the Consortium

Recruiting
N/A
550
Europe
Shallow Whole Genome Sequencing (sWGS)-GIPXplore, methylation-sensitive restriction enzymes (MSRE)-Single-molecule molecular inversion probes (smMIP)-seq assay
University Hospital, Antwerp, Universitaire Ziekenhuizen KU Leuven, Universiteit Antwerpen, KU Leuven
Neuroendocrine Neoplasms
12/28
12/30
TORPEDO, NCT06691425: Stereotactic Body Radiation Therapy for Inoperable Non-metastasized Pancreatic Adenocarcinoma

Recruiting
N/A
160
Europe
Stereotactic Body Radiation Therapy (SBRT), Chemotherapy
Cancer Research Antwerp, Kom Op Tegen Kanker, Naslund Medical AB, Varian Medical Systems
Non-metastasized Unresectable Pancreatic Carcinoma
07/30
07/30
eCAN, NCT06007001: Telerehabilitation and Tele-psychological Support in Cancer Patients JA

Recruiting
N/A
354
Europe, RoW
Telemedicine
Sciensano, European Commission
Cancer
09/24
09/24
NCT05268952: A Study to Evaluate the Value of Circulating Tumour DNA in Follow-up of Patients With an Advanced Gastroenteropancreatic or Lung Neuroendocrine Tumour Under Everolimus +- SSA Treatment (Liquid-NET 2.0)

Recruiting
N/A
100
Europe, RoW
Liquid biopsies, Scans (CT, gallium-68 DOTATE/TOC/NOC PET-CT)
University Hospital, Antwerp, Universiteit Antwerpen
Neuroendocrine Tumors
05/25
12/25
NCT05704530: Liquid Biopsies in Esophageal Cancer

Recruiting
N/A
248
Europe
Blood sample
Universitaire Ziekenhuizen KU Leuven, Kom Op Tegen Kanker
Esophageal Cancer
09/25
12/26
COPERNIC, NCT05487248: A Study of On-treatment CtDNA Changes in Chemo-refractory Colorectal Cancer Patients

Recruiting
N/A
103
Europe
Blood Sample Collection
Jules Bordet Institute, Hoffmann-La Roche
Unresectable Locally Advanced Colorectal Cancer, Metastatic Colorectal Cancer, Candidate for Third-line or Subsequent Lines of Therapy
04/26
12/26
SHAPERS, NCT06052332: Efficacy and Safety of SCRT Versus TNT in Older Patients With Locally Advanced Rectal Cancer

Recruiting
N/A
230
Europe
Short course radiotherapy, Adjuvant chemotherapy (optional), Total mesorectal excision, Total neoadjuvant therapy
Jules Bordet Institute
Locally Advanced Rectal Cancer, Older People
12/29
12/33
Quali-NET, NCT05268783: Patient-reported Outcomes in Neuroendocrine Neoplasms: a Prospective Quality of Life and Quality of Care Study Within NETwerk

Recruiting
N/A
1000
Europe
EORTC QLQ-C30, EORTC QLQ-GI.NET21, Satisfaction survey
University Hospital, Antwerp
Quality of Life
12/29
12/29
Ogunjimi, Benson
AIDA, NCT05200715: AutoInflammatory Disease Alliance Registry

Recruiting
N/A
3500
Europe, US, RoW
No intervention is foreseen by the protocol.
University of Siena
Hereditary Autoinflammatory Diseases, Schnitzler Syndrome, Behcet Syndrome, PFAPA Syndrome, Still Disease, Autoinflammatory Syndrome, Unspecified, Uveitis, Scleritis, Vexas Syndrome
08/23
08/30
FEBRIS, NCT05670301: Flemish Joint Effort for Biomarker PRofiling in Inflammatory Systemic Diseases

Recruiting
N/A
2500
Europe
cytokine and lipidomic profiling
University Hospital, Ghent, University Hospital, Antwerp, Ziekenhuis Netwerk Antwerpen (ZNA), Universitair Ziekenhuis Brussel, Jessa Hospital, Hasselt University
Autoinflammatory Disease, Autoimmune Diseases, Inflammation
12/29
12/29
Holvoet, Liesbeth
NALPAC, NCT05472259 / 2020-003889-39: A Study Evaluating the Efficacy of 5-FU + NALIRI and 5-FU + NALIRINOX for PDAC

Recruiting
2
134
Europe
Nanoliposomal irinotecan, Onyvide, 5 FU, Fluorouracil, Leucovorin, Folinate, Elvorine, Oxaliplatin
Belgian Group of Digestive Oncology, University Hospital St Luc, Brussels
Metastatic Pancreatic Ductal Adenocarcinoma
12/26
12/27
Wouters, Sanne
NALPAC, NCT05472259 / 2020-003889-39: A Study Evaluating the Efficacy of 5-FU + NALIRI and 5-FU + NALIRINOX for PDAC

Recruiting
2
134
Europe
Nanoliposomal irinotecan, Onyvide, 5 FU, Fluorouracil, Leucovorin, Folinate, Elvorine, Oxaliplatin
Belgian Group of Digestive Oncology, University Hospital St Luc, Brussels
Metastatic Pancreatic Ductal Adenocarcinoma
12/26
12/27
CAVACI, NCT05699915: Extensive CArdioVAscular Characterization and Follow-up of Patients Receiving Immune Checkpoint Inhibitors

Terminated
N/A
105
Europe
Cardiology consultation, Chest Computed Tomography (CT) without contrast, Cardiac CT, Non-invasive endothelial function tests, Flow mediated dilatation (FMD), Peripheral arterial tonometry (PAT), Electrocardiogram, ECG, Extra serum sample (7.5 mL)
Algemeen Ziekenhuis Maria Middelares
Cancer, Immune-related Adverse Event, Cardiac Abnormalities, Variable, Immune Checkpoint Inhibitor-Related Myocarditis, Diastolic Dysfunction, Atherosclerosis, Cardiotoxicity
07/24
07/24
Guerti, Khadija
FEBRIS, NCT05670301: Flemish Joint Effort for Biomarker PRofiling in Inflammatory Systemic Diseases

Recruiting
N/A
2500
Europe
cytokine and lipidomic profiling
University Hospital, Ghent, University Hospital, Antwerp, Ziekenhuis Netwerk Antwerpen (ZNA), Universitair Ziekenhuis Brussel, Jessa Hospital, Hasselt University
Autoinflammatory Disease, Autoimmune Diseases, Inflammation
12/29
12/29
Komen, Nikolaas
NCT04940611: A Study of Surgical Interventions in Fistulizing Conditions

Active, not recruiting
N/A
750
Europe, Canada, US, RoW
Takeda
Crohns Disease, Fistula, Rectovaginal Fistula, Complex Perianal Fistula, Complex Cryptoglandular Fistula
05/26
05/26
Beysen, Diane
NCT04833894 / 2020-005841-18: Evaluating the Pharmacokinetics, Pharmacodynamics, and Safety of Efgartigimod Administered Intravenously in Children with Generalized Myasthenia Gravis

Recruiting
2/3
12
Europe, Canada, US, RoW
Efgartigimod IV
argenx
Generalized Myasthenia Gravis
03/27
03/27
NCT05374590 / 2021-002460-46: Evaluating Long-term Safety of Efgartigimod Administered Intravenously and Efgartigimod PH20 Administered Subcutaneously in Children with Generalized Myasthenia Gravis

Enrolling by invitation
2/3
12
Europe, US
Efgartigimod IV or Efgartigimod PH20 SC
argenx
Generalized Myasthenia Gravis
09/28
09/28
Geert, Anja
DHELIVER, NCT04229901: Study to Evaluate the Efficacy and Safety of HepaStem in Patients With Acute on Chronic Liver Failure (ACLF)

Terminated
2
133
Europe, RoW
HepaStem, Placebo
Cellaion SA
Acute on Chronic Liver Failure
05/24
05/24

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