| Zhang, Hong |
NCT03431428: Comparison of Short-term Efficacy and Long-term Prognosis for Reduction Surgery and Radical Resection in Almost-cCR Rectal Cancer Patients |
|
|
| Recruiting | 3 | 477 | RoW | transanal surgery, Miles surgery, Preoperative chemoradiotherapy | Zhang Rui | Almost-cCR, Surgery, Rectal Cancer | 01/20 | 12/22 | | |
| Completed | 3 | 1412 | RoW | Injection of recombinant human tissue plasminogen kinase derivatives, Reteplase, brand name: Ruitongli, r-PA, Recombinant human tissue plasminogen activator, Alteplase, brand name: Actilyse, rt-PA | Angde Biotech Pharmaceutical Co., Ltd., Beijing Tiantan Hospital | Acute Ischemic Stroke | 06/23 | 06/23 | | |
NCT05629390: Trial to Evaluate the Efficacy and Safety of TP-03, LIBRA Study |
|
|
| Completed | 3 | 163 | RoW | Lotilaner, TP-03, S-Misoxam, Vehicle Control | LianBio LLC | Blepharitis | 09/23 | 04/24 | | |
NCT05745259: Thrombolysis Treated With TNK-tPA in Acute Ischemic Stroke Patients （3T Stroke-Ⅲ） |
|
|
| Recruiting | 3 | 1630 | RoW | Alteplase, rt-PA, Tenecteplase, TNK-tPA | Beijing Tiantan Hospital, Jiangsu FENG HUA Biotech Pharmaceutical Co., Ltd, The Place Pharmaceutical(Jiangsu) Co., Ltd | Acute Ischemic Stroke | 11/23 | 03/24 | | |
TaLaR-02, NCT05984485: The Efficacy of Primary Total Mesorectal Excision (TME) Surgery Versus Neoadjuvant Chemotherapy Combined With TME Surgery in Low-risk Locally Advanced Rectal Cancer |
|
|
| Recruiting | 3 | 766 | RoW | neoadjuvant chemotherapy plus total mesorectal excision, total mesorectal excision | Sun Yat-sen University | Rectal Cancer | 07/28 | 07/28 | | |
NCT05702489: A Study to Evaluate the Efficacy and Safety of ZX-7101A Tablets in Adults with Uncomplicated Influenza |
|
|
| Completed | 2/3 | 900 | RoW | ZX-7101A | Nanjing Zenshine Pharmaceuticals | Influenza, Human | 05/23 | 10/23 | | |
NCT04398459: The Safety and Efficacy of Ibrutinib in Refractory/Relapsed Autoimmune Hemolytic Anemia |
|
|
| Active, not recruiting | 2 | 18 | RoW | Ibrutinib, BTK inhibitor | Institute of Hematology & Blood Diseases Hospital, China | Refractory/Relapsed Autoimmune Hemolytic Anemia | 12/24 | 06/25 | | |
NCT05292196: A Phase II Clinical Trial of TQC3721 Suspension for Inhalation |
|
|
| Recruiting | 2 | 460 | RoW | TQC3721 suspension for inhalation, TQC3721 suspension placebo for inhalation | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Chronic Obstructive Pulmonary Disease (COPD) | 01/24 | 05/24 | | |
NCT06670352: Phase II Study of Efficacy and Safety of HSK39297 Tablet in Treatment of Patients with Primary IgAN |
|
|
| Recruiting | 2 | 80 | RoW | Placebo, HSK39297 50mgBID, HSK39297 100mgBID, HSK39297 200mgQD | Haisco Pharmaceutical Group Co., Ltd. | IgA Nephropathy (IgAN) | 11/25 | 03/26 | | |
BID-PERAL, NCT04423367: Bortezomib Plus Dexamethasone for Acquired Pure Red Cell Aplasia Failure or Relapse After First-line Treatment |
|
|
| Completed | 2 | 18 | RoW | bortezomib/dexamethasone | Institute of Hematology & Blood Diseases Hospital, China | Acquired Pure Red Cell Aplasia | 07/24 | 09/24 | | |
NCT05660785: Herombopag Added to Cyclosporine in Non Severe Aplastic Anemia |
|
|
| Active, not recruiting | 2 | 54 | RoW | Herombopag, Cyclosporine A | Institute of Hematology & Blood Diseases Hospital, China, Jiangsu Hengrui Pharmaceuticals Co.,Ltd | Non Severe Aplastic Anemia, Untreated | 01/25 | 05/25 | | |
NCT06687174: Study to Evaluate the Efficacy and Safety of MY008211A in Subjects with Primary Immunoglobulin a Nephropathy (IgAN) |
|
|
| Not yet recruiting | 2 | 72 | RoW | MY008211A tablets, MY008211A tablets matched placebo | Wuhan Createrna Science and Technology Co., Ltd | IgA Nephropathy (IgAN) | 06/26 | 01/28 | | |
NCT06760182: Clinical Trial of TQH2722 Injection in Patients With Seasonal Allergic Rhinitis |
|
|
| Not yet recruiting | 2 | 168 | RoW | TQH2722 injection, TQH2722 Placebo | Shanghai Chia Tai Tianqing Pharmaceutical Technology Development Co., Ltd. | Seasonal Allergic Rhinitis | 06/25 | 08/25 | | |
NCT04688736: Efficacy of Placebo Versus Chlorpheniramine for the Prevention of Allergic Transfusion Reactions. |
|
|
| Recruiting | 2 | 6642 | RoW | Placebo, Chlorpheniramine | Institute of Hematology & Blood Diseases Hospital, China | Allergic Transfusion Reaction | 12/25 | 06/26 | | |
NCT06774664: A Clinical Study of SCTC21C in Participants With Plasma Cell-driven Autoimmune Diseases |
|
|
| Not yet recruiting | 1/2 | 99 | RoW | SCTC21C | Sinocelltech Ltd. | IgA Nephropathy | 09/27 | 03/29 | | |
NCT04481841: Head Yuanshi Dian Therapy in Burning Mouth Syndrome |
|
|
| Recruiting | 1 | 290 | RoW | oryzanol + vitamin B2 (riboflavin) + vitamin E, head yuanshi dian therapy | Second Affiliated Hospital, School of Medicine, Zhejiang University, Zhejiang Provincial Hospital of TCM, Guiyang Hospital of Stomatology | Burning Mouth Syndrome, Oral Mucosa Disease | 02/22 | 05/22 | | |
NCT06101316: A Bridging Study to Evaluate the Safety, Tolerability, and Pharmacokinetics of CB06-036 in Healthy Subjects in China |
|
|
| Recruiting | 1 | 12 | RoW | CB06-036 | Shanghai Zhimeng Biopharma, Inc. | Healthy Volunteers | 10/23 | 12/23 | | |
NCT06216041: To Evaluate the Safety, Tolerability, Pharmacokinetics and Food Effects of IMM-H014 in Healthy Subjects |
|
|
| Recruiting | 1 | 138 | RoW | IMM-H014, Placebo, IMM-H014 ( FE), Placebo ( FE) | Changchun Intellicrown Pharmaceutical Co. LTD | Nonalcoholic Steatohepatitis (NASH) | 07/24 | 12/24 | | |
NCT06160895: A Clinical Trial of TQ-A3334 Tablet After Multiple Administration in Adult Subjects |
|
|
| Completed | 1 | 40 | RoW | TQ-A3334 tablets, TQ-A3334 placebo tablets | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Hepatitis B | 06/24 | 08/24 | | |
NCT06427681: An Relative Bioavailability Study of BH006 for Injection in Healthy Subjects |
|
|
| Not yet recruiting | 1 | 40 | NA | BH006 for injection, Fosaprepitant for injection+Palonosetron hydrochloride injection, EMEND®+PALONOSETRON | Zhuhai Beihai Biotech Co., Ltd | Bioavailability | 09/24 | 12/24 | | |
| Not yet recruiting | 1 | 18 | NA | AP303 150μg, AP303 300μg, Placebo 150μg, Placebo 300μg | Alebund Pharmaceuticals | Diabetic Kidney Disease | 01/25 | 01/25 | | |
| Completed | N/A | 980 | RoW | Rotational Atherectomy | Beijing Anzhen Hospital, BSC International Medical Trading (Shanghai) Co., Ltd. | Coronary Artery Disease | 12/20 | 01/22 | | |
UltraFuture I, NCT05498740: Post-marketing Study in Femoral Popliteal Artery of Drug Coated Balloon Used for Treatment of Lower Limb Ischemia |
|
|
| Recruiting | N/A | 200 | RoW | Drug eluting Balloon | Zhejiang Zylox Medical Device Co., Ltd. | Peripheral Arterial Disease (PAD) | 12/22 | 12/24 | | |
NCT05608980: 0.01% Hypochlorous Acid in the Treatment of Blepharitis |
|
|
| Recruiting | N/A | 100 | RoW | 0.01% hypochlorous acid, 0.01%HOCI, Placebo | Eye & ENT Hospital of Fudan University, ShuGuang Hospital | Blepharitis | 12/22 | 05/23 | | |
NCT05685966: Retrospective Study of COVID-19 on Reproductive Function |
|
|
| Recruiting | N/A | 400 | RoW | no intervention | Jinling Hospital, China | COVID-19 | 03/23 | 01/24 | | |
NCT04852406: Protocol-based Management and Perioperative Outcomes in Patients With Chronic Antithrombotic Therapy |
|
|
| Recruiting | N/A | 526 | RoW | Protocol-based management of perioperative antithrombotic therapy, Protocol-based management, Routine management of perioperative antithrombotic therapy, Routine management | Peking University First Hospital | Antithrombotic Therapy, Perioperative Care, Perioperative Outcomes | 12/23 | 01/24 | | |
NCT05685992: Novel Coronavirus Infection and Reproductive Function |
|
|
| Recruiting | N/A | 400 | RoW | no intervention | Jinling Hospital, China | COVID-19 Infection | 01/24 | 01/24 | | |
CSILS, NCT04527861: Oncologic Outcomes of Single-incision Versus Conventional Laparoscopic Surgery for Colorectal Cancer |
|
|
| Recruiting | N/A | 710 | RoW | Single-incision Laparoscopic Surgery, SILS, Conventional Laparoscopic Surgery, CLS | Ruijin Hospital, Dongfang Hospital Affiliated to Tongji University, Fudan University, Changhai Hospital, Shengjing Hospital, RenJi Hospital, Liaoning Cancer Hospital & Institute, Zhejiang Provincial People's Hospital, Shandong Provincial Hospital, The General Hospital of Western Theater Command, Shanghai Jiao Tong University School of Medicine | Colorectal Cancer, Colon Cancer, Rectal Cancer | 04/24 | 04/29 | | |
NCT04645810: A Study of Focal Salvage High-Dose-Rate Brachytherapy for Prostate Gland Only Recurrence |
|
|
| Recruiting | N/A | 12 | US | High-Dose-Rate Brachytherapy | University of Rochester | Prostate Cancer, HDR | 05/26 | 05/27 | | |
SCDB, NCT06422845: Peripheral Scoring Drug-coated Balloon in the Treatment of Hemodialysis Arteriovenous Fistula Stenosis |
|
|
| Recruiting | N/A | 328 | RoW | Dissolve AV Peripheral Scoring Drug-coated Balloon, Scoring Drug-coated Balloon | DK Medical Technology (Suzhou) Co., Ltd. | Arteriovenous Fistula Stenosis | 07/27 | 07/27 | | |
| Recruiting | N/A | 1114 | RoW | TaTME, Transanal TME, LpTME, Laparoscopic TME | Sun Yat-sen University, Peking Union Medical College Hospital, The First Hospital of Jilin University, RenJi Hospital, Shengjing Hospital, The Second People's Hospital of Yibin, Daping Hospital and the Research Institute of Surgery of the Third Military Medical University, Nanchong Central Hospital, Zunyi Medical College, The First Affiliated Hospital of University of South China, Xinqiao Hospital, Nanfang Hospital, Southern Medical University, First Affiliated Hospital Xi'an Jiaotong University, Ruijin Hospital, Affiliated Hospital of Guangdong Medical University, The Third Xiangya Hospital of Central South University | Rectal Neoplasms Malignant, Surgery | 07/26 | 07/26 | | |
| Recruiting | N/A | 10000 | RoW | Installation or registration of smartphone application | Chinese Alliance Against Lung Cancer | Solitary Pulmonary Nodule | 10/25 | 10/25 | | |
NCT04995159: Optimized Antiplatelet Therapy in Patients With CHD After Implantation of NeoVasâ„¢ BRS System |
|
|
| Not yet recruiting | N/A | 2150 | RoW | Single anti-platelet therapy, SAPT strategy, Dual anti-platelet therapy, DAPT strategy | Lepu Medical Technology (Beijing) Co., Ltd. | Coronary Heart Disease | 01/26 | 01/28 | | |
| Not yet recruiting | N/A | 550 | RoW | lymph node dissection, Fluorescence-guided laparoscopic surgery, Radical operation for rectal cancer and sigmoid Cancer | Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Fudan University, Fujian Province Tumor Hospital, Guangdong Provincial People's Hospital, Shengjing Hospital, Affiliated Hospital of Qinghai University, Hebei Medical University Fourth Hospital, The Second Affiliated Hospital of Harbin Medical University, Jiangxi Provincial Cancer Hospital, The First Hospital of Jilin University, Guangdong Provincial Hospital of Traditional Chinese Medicine, Shanxi Province Cancer Hospital, Nanfang Hospital, Southern Medical University, Second People's Hospital of Yunnan Province, Binzhou Medical University, The First Affiliated Hospital of University of Science and Technology of China, First Affiliated Hospital of Chengdu Medical College, The Second People's Hospital of Yibin, The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School | Colorectal Neoplasms, Fluorescence, Lymph Node Excision | 12/26 | 06/27 | | |
| Recruiting | N/A | 366 | Canada, RoW | | The George Institute, Peking University Institute of Nephrology | IgA Nephropathy, ESRD, Glomerulonephritis, Kidney Diseases | 07/27 | 07/27 | | |
| Morschhauser, Franck |
ALLELE, NCT03394365 / 2017-002949-30: Tabelecleucel for Solid Organ or Allogeneic Hematopoietic Cell Transplant Participants with Epstein-Barr Virus-Associated Post-Transplant Lymphoproliferative Disease (EBV+ PTLD) After Failure of Rituximab or Rituximab and Chemotherapy |
|
|
| Recruiting | 3 | 66 | Europe, Canada, US, RoW | tabelecleucel, tab-cel®, ATA129, EBV-CTL | Atara Biotherapeutics | Epstein-Barr Virus+ Associated Post-transplant Lymphoproliferative Disease (EBV+ PTLD), Solid Organ Transplant Complications, Lymphoproliferative Disorders, Allogeneic Hematopoietic Cell Transplant, Stem Cell Transplant Complications | 08/25 | 06/27 | | |
|
RELEVANCE , NCT01650701 / 2011-002792-42: A Phase 3 Open Label Randomized Study to Compare the Efficacy and Safety of Rituximab Plus Lenalidomide (CC-5013) Versus Rituximab Plus Chemotherapy Followed by Rituximab in Subjects With Previously Untreated Follicular Lymphoma |
|
|
| Completed | 3 | 1030 | Europe, Canada, RoW | Rituximab, mabthera, rituxan, Lenalidomide, Revlimid, Rituximab - CHOP, Rituximab - CVP, Rituximab - Bendamustine | The Lymphoma Academic Research Organisation, Celgene Corporation | Follicular Lymphoma | 05/17 | 04/24 | | |
|
|
| Completed | 3 | 255 | Japan, US | Rituximab, Lenalidomide, Revlimid, Rituximab-CHOP, Rituximab-CVP, Rituximab-Bendamustine | Celgene, The Lymphoma Academic Research Organisation | Follicular Lymphoma | 04/24 | 04/24 | | |
|
MorningLyte, NCT06284122: Study of Mosunetuzumab Plus Lenalidomide Compared to Anti-CD20 Anti-body + Chemotherapy in Follicular Lymphoma FLIPI2-5 |
|
|
| Recruiting | 3 | 790 | Europe | Mosunetuzumab, Lenalidomide, Rituximab, Obinutuzumab, Cyclophosphamide, Doxorubicin, Vincristin, Prednisone, Bendamustin | The Lymphoma Academic Research Organisation, Lymphoma Study Association, Swiss Group for Clinical Cancer Research, Grupo Español de Linfomas y Transplante Autólogo de Médula Ósea | Follicular Lymphoma | 11/28 | 04/34 | | |
SYMPHONY-1, NCT04224493 / 2019-003333-42: A Study to Assess the Efficacy, Safety, Pharmacodynamics, and Pharmacokinetics of Tazemetostat in Combination With Lenalidomide Plus Rituximab Versus Placebo in Combination With Lenalidomide Plus Rituximab in Adult Patients at Least 18 Years of Age With Relapsed/Refractory Follicular Lymphoma. |
|
|
| Recruiting | 3 | 612 | Europe, Canada, US, RoW | Tazemetostat, EPZ-6438, IPN60200, Placebo oral tablet, Lenalidomide, Rituximab | Epizyme, Inc. | Relapsed/Refractory Follicular Lymphoma, Follicular Lymphoma, Refractory Follicular Lymphoma | 03/26 | 03/29 | | |
|
|
|
|
|
|
|
| Active, not recruiting | 2 | 74 | Europe | Pixantrone, Pixuvri, Ifosfamide, Holoxan, Etoposide, Vepeside, Rituximab, Mabthera, Transplant | The Lymphoma Academic Research Organisation | Aggressive Non-Hodgkin Lymphoma | 06/19 | 03/25 | | |
NCT03766763: Preemptive Therapy for High Risk Chronic Lymphoid Leukemia Stage a |
|
|
| Active, not recruiting | 2 | 82 | Europe | Venetoclax | French Innovative Leukemia Organisation | Chronic Lymphoid Leukemia | 01/22 | 04/30 | | |
ALYCANTE, NCT04531046: Axi-Cel as a 2nd Line Therapy in Patients With Relapsed/Refractory Aggressive B Lymphoma Ineligible to Autologous Stem Cell Transplantation |
|
|
| Active, not recruiting | 2 | 62 | Europe | axicabtagene ciloleucel, axi-cel | The Lymphoma Academic Research Organisation | B-Cell Lymphoma Refractory, B-cell Lymphoma Recurrent | 04/22 | 06/26 | | |
| Active, not recruiting | 2 | 67 | Europe | Obinutuzumab, gazyva, RO7082859, glofitamab | The Lymphoma Academic Research Organisation | Diffuse Large B-Cell Lymphoma Refractory, Refractory Indolent Adult Non-Hodgkin Lymphoma, Refractory Transformed B-cell Non-Hodgkin Lymphoma, Refractory Primary Mediastinal Large B-Cell Cell Lymphoma, Refractory Mantle Cell Lymphoma | 01/23 | 03/26 | | |
| Active, not recruiting | 2 | 141 | Europe | Valemetostat tosylate, DS-3201b | The Lymphoma Academic Research Organisation, Daiichi Sankyo | Lymphoma, B-Cell | 10/24 | 10/24 | | |
NCT06271057: Golcadomide Post-CAR T-cell in R/R Aggressive Large B-cell Lymphoma Patients With High Risk of Relapse |
|
|
| Recruiting | 2 | 65 | Europe | golcadomide, BMS-986369, CC-99282 | The Lymphoma Academic Research Organisation, Lymphoma Study Association | Diffuse Large B-cell Lymphoma Refractory, Refractory Primary Mediastinal Large B-Cell Lymphoma, Refractory Transformed B-cell Non-Hodgkin Lymphoma, Refractory High Grade B-Cell Lymphoma | 01/26 | 10/27 | | |
| Recruiting | 2 | 56 | Europe | Lacutamab, Gemcitabine, Oxaliplatine | The Lymphoma Academic Research Organisation, Innate Pharma | Peripheral T Cell Lymphoma, Relapse/Recurrence | 01/25 | 01/27 | | |
|
GLOASIS, NCT06558604: A Phase II Study Evaluating Glofitamab in Combination With Venetoclax Plus Zanubrutinib or Venetoclax Alone in Subjects With Untreated or Relapsed/Refractory High-risk Mantle-cell Lymphoma |
|
|
| Recruiting | 2 | 100 | Europe | Obinutuzumab, Glofitamab, Venetoclax Oral Product, Zanubrutinib Oral Capsule | The Lymphoma Academic Research Organisation, BeiGene, Hoffmann-La Roche | Lymphoma, Mantle-Cell | 05/28 | 03/32 | | |
| Recruiting | 2 | 180 | Europe, Japan, US, RoW | Epcoritamab, GEN3013, DuoBody®-CD3×CD20, EPKINLY™, Lenalidomide, Revlimid® | Genmab, AbbVie | Diffuse Large B-Cell Lymphoma | 01/26 | 03/27 | | |
OASIS-II, NCT04802590: Study of Ibrutinib + CD20 Antibody and Venetoclax in Patients With Untreated Mantle Cell Lymphoma |
|
|
| Recruiting | 2 | 194 | Europe | Ibrutinib 560 mg, Venetoclax 10 MG Oral Tablet [Venclexta], Venetoclax 50 MG Oral Tablet [Venclexta], Venetoclax 100 MG Oral Tablet [Venclexta] | The Lymphoma Academic Research Organisation, Institute of Cancer Research, United Kingdom | Mantle Cell Lymphoma | 03/26 | 09/31 | | |
NCT01582776 / 2011-005150-62: Study of OBINUTUZUMAB Combined to LENALIDOMIDE for the Treatment of Relapsed/Refractory Follicular and Aggressive B-cell Lymphoma |
|
|
| Completed | 1/2 | 317 | Europe | Lenalidomide and GA101, Revlimid, Obinutuzumab | The Lymphoma Academic Research Organisation | Follicular Lymphoma Patients (Phase IB), Follicular and Agressive (DLBCL&MCL) B-cell Lymphoma Patients (Phase II) | 07/18 | 05/22 | | |
| Recruiting | 1/2 | 118 | Europe, RoW | Lenalidomide, Revlimid, Ibrutinib, Imbruvica | Institut Curie, National Cancer Institute, France | Lymphoma, Large B-Cell, Diffuse, Central Nervous System Neoplasms, Primary | 02/25 | 02/35 | | |
| Recruiting | 1/2 | 184 | Europe, US, RoW | IPH6501 | Innate Pharma | Non Hodgkin Lymphoma | 12/28 | 12/28 | | |
NCT02576496: Study of Tinostamustine, First-in-Class Alkylating HDACi Fusion Molecule, in Relapsed/Refractory Hematologic Malignancies |
|
|
| Completed | 1 | 106 | Europe, US | Tinostamustine, EDO-S101 | Mundipharma Research Limited | Hematological Malignancies, Multiple Myeloma, Hodgkin's Lymphoma, Cutaneous T Cell Lymphoma | 05/23 | 11/23 | | |
ALK-OBS, NCT03603847: Prospective Study of the Prognostic Value of New Markers in Adults With ALK-positive Large Anaplastic Lymphoma |
|
|
| Completed | N/A | 41 | Europe | | The Lymphoma Academic Research Organisation, Hôpital Necker-Enfants Malades, Fondation ARC, Pfizer, Takeda | Anaplastic Large Cell Lymphoma, ALK-Positive | 06/23 | 06/23 | | |
NCT05529524: Signatures of Response and Resistance to Mosunetuzomab in Follicular Lymphomas (FL) |
|
|
| Completed | N/A | 6 | Europe | | The Lymphoma Academic Research Organisation, Roche Pharma AG | Follicular Lymphoma | 01/24 | 01/24 | | |
| Recruiting | N/A | 6000 | Europe | Real-life epidemiological platform of lymphoma in France | Hospices Civils de Lyon, The Lymphoma Academic Research Organisation | Diffuse Large B Lymphoma (DLBCL), Follicular Lymphoma (FL), Mantle Cell Lymphoma (MCL), Marginal Zone Lymphoma (MZL), T-cell Lymphoma (T-NHL), Hodgkin's Lymphoma (HL), Burkitt Lymphoma (BL)) | 11/27 | 11/27 | | |
| Recruiting | N/A | 204 | Europe | Chemotherapy + follow up, Chemotherapy + ASCT + follow up | Hospices Civils de Lyon | Peripheral T Cell Lymphoma | 04/28 | 04/28 | | |
| Thieblemont, Catherine |
MorningLyte, NCT06284122: Study of Mosunetuzumab Plus Lenalidomide Compared to Anti-CD20 Anti-body + Chemotherapy in Follicular Lymphoma FLIPI2-5 |
|
|
| Recruiting | 3 | 790 | Europe | Mosunetuzumab, Lenalidomide, Rituximab, Obinutuzumab, Cyclophosphamide, Doxorubicin, Vincristin, Prednisone, Bendamustin | The Lymphoma Academic Research Organisation, Lymphoma Study Association, Swiss Group for Clinical Cancer Research, Grupo Español de Linfomas y Transplante Autólogo de Médula Ósea | Follicular Lymphoma | 11/28 | 04/34 | | |
BRUIN CLL-322, NCT04965493 / 2021-000043-49: A Trial of Pirtobrutinib (LOXO-305) Plus Venetoclax and Rituximab (PVR) Versus Venetoclax and Rituximab (VR) in Previously Treated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) |
|
|
| Recruiting | 3 | 600 | Europe, Canada, Japan, US, RoW | Pirtobrutinib, LOXO-305, LY3527727, Venetoclax, Venclexta, Venclyxto, Rituximab, Rituxan, MabThera, Truxima, Riabni, Ruxience | Loxo Oncology, Inc., Eli Lilly and Company | Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma | 04/26 | 01/27 | | |
SYMPHONY-1, NCT04224493 / 2019-003333-42: A Study to Assess the Efficacy, Safety, Pharmacodynamics, and Pharmacokinetics of Tazemetostat in Combination With Lenalidomide Plus Rituximab Versus Placebo in Combination With Lenalidomide Plus Rituximab in Adult Patients at Least 18 Years of Age With Relapsed/Refractory Follicular Lymphoma. |
|
|
| Recruiting | 3 | 612 | Europe, Canada, US, RoW | Tazemetostat, EPZ-6438, IPN60200, Placebo oral tablet, Lenalidomide, Rituximab | Epizyme, Inc. | Relapsed/Refractory Follicular Lymphoma, Follicular Lymphoma, Refractory Follicular Lymphoma | 03/26 | 03/29 | | |
|
|
|
|
|
|
|
MARSUN, NCT06006117: Mosunetuzumab-Lenalidomide Versus Investigator Choices in Patients With Relapsed or Refractory Marginal Zone Lymphoma |
|
|
| Recruiting | 3 | 260 | Europe | Mosunetuzumab + Lenalidomide, Arm 1, - Rituximab + Lenalidomide (28-days cycles, Arm 2, - Rituximab + Bendamustine (28-days cycles), Arm 3, - Rituximab + CHOP (21-days cycles), Arm 4 | The Lymphoma Academic Research Organisation | Marginal Zone Lymphoma | 09/27 | 09/32 | | |
RITZ, NCT05735834: Comparison Between Rituximab Plus Zanubrutinib Versus Rituximab Monotherapy in Untreated SMZL Patients |
|
|
| Recruiting | 3 | 120 | Europe | Rituximab, Truxima, Zanubrutinib, Brukinsa | International Extranodal Lymphoma Study Group (IELSG) | Splenic Marginal Zone Lymphoma | 05/29 | 05/29 | | |
ALYCANTE, NCT04531046: Axi-Cel as a 2nd Line Therapy in Patients With Relapsed/Refractory Aggressive B Lymphoma Ineligible to Autologous Stem Cell Transplantation |
|
|
| Active, not recruiting | 2 | 62 | Europe | axicabtagene ciloleucel, axi-cel | The Lymphoma Academic Research Organisation | B-Cell Lymphoma Refractory, B-cell Lymphoma Recurrent | 04/22 | 06/26 | | |
| Active, not recruiting | 2 | 67 | Europe | Obinutuzumab, gazyva, RO7082859, glofitamab | The Lymphoma Academic Research Organisation | Diffuse Large B-Cell Lymphoma Refractory, Refractory Indolent Adult Non-Hodgkin Lymphoma, Refractory Transformed B-cell Non-Hodgkin Lymphoma, Refractory Primary Mediastinal Large B-Cell Cell Lymphoma, Refractory Mantle Cell Lymphoma | 01/23 | 03/26 | | |
| Active, not recruiting | 2 | 168 | Europe, RoW | MB-CART2019.1, R-GemOx or BR plus polatuzumab vedotin, Rituximab, Gemcitabine, Oxaliplatin, Polatuzumab vedotin, Bendamustine, Rituximab | Miltenyi Biomedicine GmbH, ICON plc | Diffuse Large B-cell Lymphoma | 12/24 | 07/29 | | |
NCT06271057: Golcadomide Post-CAR T-cell in R/R Aggressive Large B-cell Lymphoma Patients With High Risk of Relapse |
|
|
| Recruiting | 2 | 65 | Europe | golcadomide, BMS-986369, CC-99282 | The Lymphoma Academic Research Organisation, Lymphoma Study Association | Diffuse Large B-cell Lymphoma Refractory, Refractory Primary Mediastinal Large B-Cell Lymphoma, Refractory Transformed B-cell Non-Hodgkin Lymphoma, Refractory High Grade B-Cell Lymphoma | 01/26 | 10/27 | | |
| Active, not recruiting | 2 | 175 | Europe | Ibrutinib, Rituximab | International Extranodal Lymphoma Study Group (IELSG), Janssen-Cilag AG, F. Hoffmann La Roche Ltd, Janssen Pharmaceutica NV | Marginal Zone Lymphoma, Nodal Marginal Zone Lymphoma, Splenic Marginal Zone Lymphoma | 06/27 | 06/27 | | |
Relyage, NCT04113226: Assessment of Survival and Autonomy With Rituximab Plus Chemotherapy or Rituximab Plus Lenalidomide for Elderly Patients With Relapsed Diffuse Large B-cell Lymphoma |
|
|
| Recruiting | 2 | 114 | Europe | Rituximab, Lenalidomide 20 MG, Comprehensive Geriatric Assessment (CGA), Activities of daily living (ADL) scale | Centre Hospitalier Universitaire, Amiens, cimiez hospital Nice, Institut Bergonié, groupe hospitalier public sud de l'oise, Henri Mondor University Hospital, Centre Henri Becquerel, Hôpital Charles Foix, Saint-Louis Hospital, Paris, France | Chemotherapy, Diffuse Large B-Cell Lymphoma (DLBCL), Nos, Elderly | 12/24 | 12/24 | | |
| Recruiting | 2 | 56 | Europe | Lacutamab, Gemcitabine, Oxaliplatine | The Lymphoma Academic Research Organisation, Innate Pharma | Peripheral T Cell Lymphoma, Relapse/Recurrence | 01/25 | 01/27 | | |
|
| Recruiting | 2 | 180 | Europe, Japan, US, RoW | Epcoritamab, GEN3013, DuoBody®-CD3×CD20, EPKINLY™, Lenalidomide, Revlimid® | Genmab, AbbVie | Diffuse Large B-Cell Lymphoma | 01/26 | 03/27 | | |
OASIS-II, NCT04802590: Study of Ibrutinib + CD20 Antibody and Venetoclax in Patients With Untreated Mantle Cell Lymphoma |
|
|
| Recruiting | 2 | 194 | Europe | Ibrutinib 560 mg, Venetoclax 10 MG Oral Tablet [Venclexta], Venetoclax 50 MG Oral Tablet [Venclexta], Venetoclax 100 MG Oral Tablet [Venclexta] | The Lymphoma Academic Research Organisation, Institute of Cancer Research, United Kingdom | Mantle Cell Lymphoma | 03/26 | 09/31 | | |
| Recruiting | N/A | 350 | Europe | | International Extranodal Lymphoma Study Group (IELSG) | Marginal Zone Lymphoma | 12/25 | 12/25 | | |
ALK-OBS, NCT03603847: Prospective Study of the Prognostic Value of New Markers in Adults With ALK-positive Large Anaplastic Lymphoma |
|
|
| Completed | N/A | 41 | Europe | | The Lymphoma Academic Research Organisation, Hôpital Necker-Enfants Malades, Fondation ARC, Pfizer, Takeda | Anaplastic Large Cell Lymphoma, ALK-Positive | 06/23 | 06/23 | | |
NCT06712459: Integrated Molecular and Clinical Profiling of Transformed Splenic Marginal Zone Lymphoma |
|
|
| Not yet recruiting | N/A | 100 | Europe, US | | International Extranodal Lymphoma Study Group (IELSG) | Transformed Splenic Marginal Zone Lymphoma | 03/29 | 03/29 | | |
THEMIS, NCT05350826: Evaluation of the Ambulatory Medical Assistance Nurse Program in Chronic Lymphocytic Leukemia |
|
|
| Recruiting | N/A | 450 | Europe | Ambulatory medical assistance | University Hospital, Toulouse | Chronic Lymphoid Leukemia | 07/25 | 07/25 | | |
| Recruiting | N/A | 6000 | Europe | Real-life epidemiological platform of lymphoma in France | Hospices Civils de Lyon, The Lymphoma Academic Research Organisation | Diffuse Large B Lymphoma (DLBCL), Follicular Lymphoma (FL), Mantle Cell Lymphoma (MCL), Marginal Zone Lymphoma (MZL), T-cell Lymphoma (T-NHL), Hodgkin's Lymphoma (HL), Burkitt Lymphoma (BL)) | 11/27 | 11/27 | | |
| Recruiting | N/A | 5000 | Europe | | The Lymphoma Academic Research Organisation, Gilead Sciences, Novartis, Bristol-Myers Squibb | Hematopathology Eligible or CAR-t Cell Treatment | 12/38 | 12/38 | | |
NCT05700149: Integrated Molecular and Clinical Profiling to Improve Disease Characterization and Outcome Prediction in Nodal Marginal Zone Lymphoma |
|
|
| Recruiting | N/A | 300 | Europe, US, RoW | | International Extranodal Lymphoma Study Group (IELSG) | Nodal Marginal Zone Lymphoma | 12/26 | 12/26 | | |
| Ellard, Susan |
| Active, not recruiting | 3 | 654 | Europe, Canada, Japan, US, RoW | Tucatinib, TUKYSA, ONT-380, ARRY-380, Trastuzumab, Herceptin, Herceptin Hylecta, Pertuzumab, Perjeta, Combination product: Trastuzumab + Pertuzumab, Phesgo, Placebo | Seagen Inc., Merck Sharp & Dohme LLC | HER2 Positive Breast Cancer | 05/25 | 10/27 | | |
| Recruiting | 2 | 60 | Canada, US | Durvalumab, BA3011, BA3021, ENB003, Toripalimab | Canadian Cancer Trials Group, Cancer Research Institute, New York City, AstraZeneca, BioAtla, Inc. | Ovarian Cancer | 06/25 | 12/25 | | |
| Recruiting | 2 | 240 | Europe, Canada, US, RoW | SKB264, Pembrolizumab, Keytruda | Klus Pharma Inc., Myriad Genetics, Inc., Discovery Life Sciences, LLC, Ventana Medical Systems, Inc, Frontage Laboratories, Inc. | Solid Tumor | 11/26 | 12/27 | | |
GARNET, NCT02715284: Study of TSR-042, an Anti-programmed Cell Death-1 Receptor (PD-1) Monoclonal Antibody, in Participants With Advanced Solid Tumors |
|
|
| Recruiting | 1 | 740 | Europe, Canada, US, RoW | Dostarlimab | Tesaro, Inc. | Neoplasms | 05/26 | 10/27 | | |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
PC-PEP, NCT04895839: Predictors of Mental Health in Men With Prostate Cancer Undergoing a Patient Empowerment Program |
|
|
| Recruiting | N/A | 500 | Canada, RoW | Patient Empowerment Program | Nova Scotia Health Authority | Prostate Cancer | 09/25 | 10/25 | | |
| Niu, Junqi |
| Active, not recruiting | 4 | 640 | RoW | Tenofovir Amibufenamide（TMF）, HS-10234 | Jiangsu Hansoh Pharmaceutical Co., Ltd. | Hepatitis B, Chronic | 06/24 | 09/29 | | |
NCT06715319: Obeticholic Acid Versus Placebo, in Combination with Ursodeoxycholic Acid in Patients with Primary Biliary Cirrhosis |
|
|
| Completed | 3 | 100 | RoW | OCA, Obeticholic Acid, UDCA, Placebo | Shanghai Fudan-Zhangjiang Bio-Pharmaceutical Co., Ltd. | PBC | 10/23 | 04/24 | | |
NCT04543565: Pradefovir Treatment for the Patients With Chronic Hepatitis B Virus Infections: a Phase3 Study |
|
|
| Recruiting | 3 | 900 | RoW | Pradefovir Mesylate;Placebo of Tenofovir disoproxil fumarate tablet, Tenofovir disoproxil fumarate tablet;Placebo of Pradefovir Mesylate | Xi'an Xintong Pharmaceutical Research Co.,Ltd. | Chronic Hepatitis b | 10/22 | 12/24 | | |
NCT04956328: Study of Obeticholic Acid（OCA） Combination With Ursodeoxycholic Acid (UDCA) in Patients With Primay Biliary Cirrhosis (PBC) |
|
|
| Recruiting | 3 | 120 | RoW | Obeticholic Acid Tablets, UDCA, Placebo | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Primary Biliary Cirrhosis | 09/23 | 09/23 | | |
NATiV3, NCT04849728: A Phase 3 Study Evaluating Efficacy and Safety of Lanifibranor Followed by an Active Treatment Extension in Adult Patients With (NASH) and Fibrosis Stages F2 and F3 ( ) |
|
|
| Recruiting | 3 | 1000 | Europe, Canada, US, RoW | IVA337, Lanifibranor, Placebo | Inventiva Pharma | NASH - Nonalcoholic Steatohepatitis | 09/25 | 09/26 | | |
| Active, not recruiting | 3 | 871 | Europe, Canada, Japan, US, RoW | Bepirovirsen, Placebo | GlaxoSmithKline, GlaxoSmithKline Research & Development Limited | Chronic Hepatitis B, Hepatitis B, Chronic | 11/25 | 05/26 | | |
NCT05395416: Antaitavir Hasophate Capsules Combined With Yiqibuvir Tablets in Treatment Adult Patients With Chronic Hepatitis C |
|
|
| Recruiting | 2/3 | 520 | RoW | HEC74647PA+HEC110114, Antaitavir Hasophate+Yiqibuvir, Placebo | Sunshine Lake Pharma Co., Ltd. | Chronic HCV Infection | 04/23 | 04/23 | | |
NCT04278820: A Study of TQA3526 in the Treatment of Primary Biliary Cirrhosis (PBC) |
|
|
| Not yet recruiting | 2a | 130 | RoW | TQA3526, Placebo to match TQA3526 | Chia Tai Tianqing Pharmaceutical Group Co., Ltd. | Primary Biliary Cirrhosis | 11/22 | 11/22 | | |
NCT05484466: A Study to Evaluate the Efficacy and Safety of ZM-H1505R in Combination With ETV Compared With ETV Monotherapy in Patients With CHB |
|
|
| Recruiting | 2a | 90 | RoW | ZM-H1505R, ZM-H1505R placebo, Baraclude | Shanghai Zhimeng Biopharma, Inc., Tigermed Consulting Co., Ltd | Hepatitis B, Chronic | 12/22 | 12/24 | | |
NCT04157257: An Study to Evaluate Safety and Efficacy of QL-007 Tablets in Combination With Entecavir or Tenofovir in Patients With Chronic Hepatitis b Who Have Received Nucleoside (Acid) Therapy |
|
|
| Recruiting | 2 | 60 | RoW | TDF tablet, Tenofovir dipirofurate fumarate tablet, Entecavir Tablet, Entecavir, QL-007, QL-007 tablet | Qilu Pharmaceutical Co., Ltd. | Chronic Hepatitis b | 12/20 | 10/22 | | |
NCT04157699: An Study to Evaluate Safety and Efficacy of QL-007 Tablets in Combination With Tenofovir in Naive Patients With Chronic Hepatitis b |
|
|
| Recruiting | 2 | 100 | RoW | TDF tablet, Tenofovir disoproxil fumarate tablet, QL-007 | Qilu Pharmaceutical Co., Ltd. | Chronic Hepatitis b | 12/20 | 10/22 | | |
NCT05734807: A Study to Evaluate the Antiviral Activity and Safety of HH-003 in Chronic Hepatitis B Subjects With Low-level Viremia |
|
|
| Completed | 2 | 74 | RoW | Nucleoside/nucleotide reverse transcriptase inhibitors (NrtIs), HH-003 and NrtIs, HH-003, NrtIs and PEG-IFN-α | Huahui Health | Chronic HBV Infection | 04/24 | 04/24 | | |
NCT04147208: Evaluate the Safety, Tolerability, and Antiviral Activity of GLS4 With Ritonavir in Patients With Chronic HBV Infection |
|
|
| Completed | 2 | 250 | RoW | GLS4, Morphothiadine Mesilate Capsules, RTV, Ritonavir tablet, ETV, Entecavir table | Sunshine Lake Pharma Co., Ltd. | Chronic HBV Infection | 06/22 | 09/23 | | |
NCT05637541: Evaluation of The Safety, Efficacy and Pharmacokinetic Characteristics of GST-HG141 Tablets |
|
|
| Recruiting | 2 | 90 | RoW | GST-HG141 | Fujian Akeylink Biotechnology Co., Ltd. | Chronic Hepatitis b | 08/23 | 12/23 | | |
NCT05827146: Study of Hepalatide in Chronic Hepatitis D(CHD) Patients |
|
|
| Completed | 2 | 23 | RoW | Hepalatide, L47, Hepalatide Placebo, Placebo | Shanghai HEP Pharmaceutical Co., Ltd. | Chronic Hepatitis D Infection | 01/24 | 02/24 | | |
NCT05193916: A Phase II Clinical Trial of Chiglitazar for NASH |
|
|
| Completed | 2 | 104 | RoW | chiglitazar sodium tablets, Bilessglu®, CS-038, Carfloglitazar, Placebo, simulant of chiglitazar | Chipscreen Biosciences, Ltd. | NASH | 01/24 | 01/24 | | |
