Active, not recruiting

N/A

600

Europe

CAD with LCI for colorectal polyp detection

Johannes Gutenberg University Mainz

Focus of the Study is to Evaluate a New Developed Deep-learning Computer-aided Detection System in Combination With LCI for Colorectal Polyp Detection

08/20

09/20

Recruiting

N/A

404

Europe

Plenvu

Johannes Gutenberg University Mainz

Quality Standards in Colonoscopy, Patient Education, Acceptance of Bowel-preparation

01/21

06/21

Completed

N/A

830

Europe, US

Computer Aided Detection (CADe)

NEC Corporation, Meditrial Europe Ltd., Meditrial USA Inc.

Colorectal Cancer, Adenoma Colon, Polyp of Colon

09/24

09/24

Active, not recruiting

3

500

Europe, Canada, Japan, US, RoW

Pirtobrutinib, LOXO-305, LY3527727, Ibrutinib, Imbruvica, Acalabrutinib, Calquence, Zanubrutinib, Brukinsa

Loxo Oncology, Inc., Eli Lilly and Company

Lymphoma, Mantle-Cell

12/25

07/26

Recruiting

3

612

Europe, Canada, US, RoW

Tazemetostat, EPZ-6438, IPN60200, Placebo oral tablet, Lenalidomide, Rituximab

Epizyme, Inc.

Relapsed/Refractory Follicular Lymphoma, Follicular Lymphoma, Refractory Follicular Lymphoma

03/26

03/29

Completed

N/A

68

Europe

BIOVALVE prosthesis

Biotronik AG, Medstar Health Research Institute

Heart Valve Diseases, Aortic Valve Stenosis

03/18

05/23

Not yet recruiting

N/A

600

Europe

Transcatheter Aortic Valve Implantation (TAVI)

JenaValve Technology, Inc.

Aortic Valve Stenosis, Aortic Valve Regurgitation, Aortic Valve Stenosis With Insufficiency, Constriction, Pathologic, Aortic Valve Disease, Heart Valve Diseases, Cardiovascular Diseases in Old Age, Ventricular Outflow Obstruction, Aortic Stenosis, Severe

10/23

10/27

Not yet recruiting

N/A

1016

NA

Transcatheter Aortic Valve Replacement (TAVR) using Trilogy THV System, SAVR

JenaValve Technology, Inc.

Aortic Regurgitation, Aortic Valve Insufficiency, Aortic Insufficiency

02/26

02/36

Recruiting

N/A

500

Europe, Canada, US

MitraClip™ device implantation, Mitral Valve Repair Surgery

Abbott Medical Devices

Mitral Valve Regurgitation

04/26

04/34

Completed

4

200

Europe

Quantitative flow ratio, Assessment of angiographic severity of the stenosis

Johannes Gutenberg University Mainz

Coronary Artery Disease

04/23

04/24

Recruiting

4

132

Europe

Bisoprolol, beta blocker, Diltiazem, Placebo

Charite University, Berlin, Germany, Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK)

Coronary Microvascular Dysfunction, Microvascular Angina, Vasospasm, Coronary, Vasospastic Angina, Prinzmetal Angina, Coronary Artery Disease

06/24

06/24

Recruiting

4

100

Europe

RFR, FFR

Johannes Gutenberg University Mainz

Coronary Artery Disease

06/25

06/25

Completed

N/A

185

Europe

Comprehensive Cardiovascular magnetic resonance (CMR), Blood sampling, TTE (EchoErgo), Invasive pressure-volume (PV) Loops, Left ventricular (LV) biopsy

Goethe University, Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK)

Heart Failure With Normal Ejection Fraction

12/22

12/22

Recruiting

N/A

1000

Europe

observational only- no intervention

Johannes Gutenberg University Mainz

Coronary Artery Disease, Microvascular Dysfunction

09/28

09/28

Recruiting

N/A

1000

Europe

Assessment of microvascular function with intracoronary hemodilution

Johannes Gutenberg University Mainz

Microvascular Disease

10/24

10/29

Recruiting

N/A

144

Europe

Coronary sinus reducer, Optimal medical therapy

Johannes Gutenberg University Mainz, Neovasc Inc.

Coronary Microvascular Disease, Refractory Angina

10/25

10/29

Recruiting

N/A

1000

Europe

Coronary physiology assessment, Parameters of coronary physiology in response to microvascular vasodilators (adenosine, papaverine) and acetylcholine

Johannes Gutenberg University Mainz

Coronary Microvascular Disease, Coronary Vasospasm

08/28

08/28

Completed

2

203

Europe, US, RoW

Olorofim, F901318

F2G Biotech GmbH, Iqvia Pty Ltd

Invasive Fungal Infections

02/23

02/23

Completed

1/2

15

Europe, Canada, US, RoW

Modakafusp Alfa, TAK-573, Daratumumab

Takeda, Takeda Development Center Americas, Inc.

Multiple Myeloma

05/24

05/24

Recruiting

N/A

99999

US

A multicenter access and distribution protocol for unlicensed cryopreserved cord blood units (CBUs)

Center for International Blood and Marrow Transplant Research, National Marrow Donor Program

Hematologic Malignancies, Inherited Disorders of Metabolism, Inherited Abnormalities of Platelets, Histiocytic Disorders, Acute Myelogenous Leukemia (AML or ANLL), Acute Lymphoblastic Leukemia (ALL), Other Acute Leukemia, Chronic Myelogenous Leukemia (CML), Myelodysplastic (MDS) / Myeloproliferative (MPN) Diseases, Other Leukemia, Hodgkin Lymphoma, Non-hodgkin Lymphoma, Multiple Myeloma/ Plasma Cell Disorder (PCD), Inherited Abnormalities of Erythrocyte Differentiation or Function, Disorders of the Immune System, Autoimmune Diseases, Severe Aplastic Anemia

10/41

10/41

Completed

N/A

505

Europe, RoW

MitraClip, standard of care

University Medical Center Goettingen, University Medical Center Goettingen

Mitral Valve Insufficiency

04/24

04/24

Recruiting

N/A

800

Europe, Canada, US, RoW

Universitätsklinikum Hamburg-Eppendorf, Montreal Heart Institute, University Hospital, Bordeaux

Mitral Regurgitation

03/25

12/30

Recruiting

N/A

590

Europe, RoW

Navitor Transcatheter Aortic Valve and FlexNav Delivery System

Abbott Medical Devices

Symptomatic Severe Aortic Stenosis

06/25

02/36

Recruiting

N/A

400

Europe

Medtronic Intrepid™ TMVR TF System

Medtronic Cardiovascular

Mitral Regurgitation

08/29

12/38

Recruiting

N/A

100

Europe

Intermittent fasting, Time restricted feeding, DGE diet

Johannes Gutenberg University Mainz, University of Turin, Italy

Fatty Liver Disease, Fatty Liver, Fatty Liver, Nonalcoholic

09/24

12/24

Recruiting

N/A

10000

Europe

Newcastle University, Newcastle-upon-Tyne Hospitals NHS Trust, Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Institute of Cardiometabolism and Nutrition, France, University of Cambridge, Örebro University, Sweden, University of Bern, University of Oxford, University of Turin, Italy, University of Angers, University Hospital, Antwerp, Linkoeping University, University of Helsinki, UMC Utrecht, National and Kapodistrian University of Athens, University of Lisbon, University of Milan, University of Palermo, Catholic University of the Sacred Heart, Wuerzburg University Hospital, RWTH Aachen University, University of Nottingham, Medical University of Vienna, University of Birmingham, University of Florence, Assistance Publique - Hôpitaux de Paris, University Medical Center Mainz

NAFLD, NASH, NASH - Nonalcoholic Steatohepatitis, Fibrosis, Liver, Steatosis of Liver, Hepatocellular Carcinoma, Cardiovascular Diseases, Type 2 Diabetes, Dyslipidaemia, Hypertension, Obesity, Other Associated Comorbidities

12/30

12/30

Recruiting

3

100

Europe

Edoxaban

Erasmus Medical Center, Daiichi Sankyo, Inc.

Aortic Valve Stenosis

06/23

09/23

Active, not recruiting

N/A

4

US, RoW

Millipede Transcatheter Annuloplasty Ring System (Millipede System)

Boston Scientific Corporation

Mitral Regurgitation Functional, Mitral Valve Disease, Cardiovascular Diseases

12/21

11/26

Active, not recruiting

N/A

1525

Europe

Percutaneous coronary intervention, PCI

Erasmus Medical Center, Biotronik SE & Co. KG

Acute Coronary Syndrome

10/22

10/26

Active, not recruiting

N/A

252

Europe, Canada

Transcatheter Aortic Valve Implantation with ACURATE Neo Aortic Bioprosthesis

Erasmus Medical Center, Boston Scientific Corporation

Aortic Valve Stenosis

12/22

02/24

Recruiting

N/A

90

Europe

Percutaneous arterial closure device

Vivasure Medical Limited

Percutaneous Arteriotomy Closure

01/23

03/23

Active, not recruiting

N/A

178

Europe, Canada, US

SAPIEN 3 THV, Optimal Heart Failure Therapy

Cardiovascular Research Foundation, New York, Cardialysis BV, Avania

Aortic Valve Stenosis

02/23

02/25

Recruiting

N/A

20

Europe

Pressure-volume loop measurements

Erasmus Medical Center

Extracorporeal Membrane Oxygenation, Cardio/Pulm: Heart Failure

11/24

12/24

Not yet recruiting

N/A

400

Europe

Intra-Aortic Balloon Pump

Erasmus Medical Center, Arrow International LCC (Subsidiary of Teleflex Inc.)

Cardiogenic Shock

06/27

06/27

Active, not recruiting

N/A

527

Europe, Canada, US

Impella CP® placement prior to reperfusion with Primary PCI

Abiomed Inc.

ST Elevation (STEMI) Myocardial Infarction of Anterior Wall

09/24

10/30

Recruiting

N/A

590

Europe, RoW

Navitor Transcatheter Aortic Valve and FlexNav Delivery System

Abbott Medical Devices

Symptomatic Severe Aortic Stenosis

06/25

02/36

Recruiting

N/A

650

Europe, Canada, Japan, US, RoW

Medtronic Evolut PRO+ TAVR System, or Evolut FX TAVR System, and guideline-directed management and therapy (GDMT)

Medtronic Cardiovascular

Moderate Aortic Valve Stenosis

02/26

12/34

Recruiting

N/A

400

Europe

Medtronic Intrepid™ TMVR TF System

Medtronic Cardiovascular

Mitral Regurgitation

08/29

12/38

Not yet recruiting

N/A

456

Europe

Impella 5.5, Inotropes

Amsterdam UMC, location VUmc, Abiomed Inc.

Cardiogenic Shock

10/27

07/28

Recruiting

N/A

1500

Europe, Canada, RoW

Universitätsklinikum Hamburg-Eppendorf, Institut universitaire de cardiologie et de pneumologie de Québec

Low-Flow, Low-Gradient Aortic Stenosis

12/22

12/25

Recruiting

4

108

Europe

Ontruzant, SB3, Chemotherapy, Pertuzumab

Institut fuer Frauengesundheit, Samsung Bioepis Co., Ltd.

Breast Cancer, Breast Neoplasms, Breast Cancer Female, HER2-positive Breast Cancer

04/23

07/23

Active, not recruiting

3

1332

Europe

Capecitabine, Xeloda, Carboplatin, Paraplatin, Cisplatin, Platinol, Sacituzumab govitecan, Trodelvy

German Breast Group, Gilead Sciences, Austrian Breast & Colorectal Cancer Study Group, Spanish Breast Cancer Research Group (GEICAM), ETOP IBCSG Partners Foundation, Cancer Trials Ireland, UNICANCER

HER2-negative Breast Cancer, Triple Negative Breast Cancer

03/27

03/29

Completed

2

416

Europe

Atezolizumab 840 MG in 14 ML Injection, Tecentriq, Atezolizumab 1200 MG in 20 ML Injection, Carboplatin, Paclitaxel, Epirubicin, Cyclophosphamide, Biopsy Arm A, Biopsy Arm B, Surgery

Palleos Healthcare GmbH, Roche Pharma AG, Phaon Scientific GmbH, University Hospital, Essen, University Hospital Erlangen

Triple-negative Breast Cancer

07/23

10/24

Recruiting

3

251

Europe, Canada, Japan, US, RoW

Linerixibat

GlaxoSmithKline, GlaxoSmithKline LLC, GlaxoSmithKline Research & Development Limited

Cholestasis

02/27

02/27

Recruiting

2

200

Europe, Canada, US, RoW

Volixibat, SHP626, Placebo

Mirum Pharmaceuticals, Inc., Mirum Pharmaceuticals, Inc.

Primary Sclerosing Cholangitis

09/25

12/25

Not yet recruiting

N/A

630

Europe

Standardized assessments, guided tumor biopsy and biobanking, Standardized assessments and biobanking

Assistance Publique - Hôpitaux de Paris, University Luxembourg (UNILU) - ELIXIR, Hospital Universitario La Fe, ECRIN EUROPEAN CLINICAL RESEARCH INFRASTRUCTURE NETWORK (ECRIN), Ophiomics - Precision Medicine, EF CLIF, INSERM 1149, INSERM U1052

Decompensated Liver Cirrhosis, Primary Biliary Cholangitis, Primary Sclerosing Cholangitis, Hepato-cellular Carcinoma

01/27

10/27

Recruiting

N/A

3000

Europe, Canada, Japan, US, RoW

Observational Protocol

European Foundation for Study of Chronic Liver Failure

Liver Diseases, Liver Cirrhosis, Acute-On-Chronic Liver Failure, Liver Transplant; Complications

12/25

12/26

Recruiting

N/A

500

Europe

HCCRecurrencePrognosticScore, HCCRecurrenceDiagnosticScore

University Hospital, Ghent, University Hospital, Antwerp, Universitaire Ziekenhuizen KU Leuven, Cliniques universitaires Saint-Luc- Université Catholique de Louvain

Prognostic Biomarker, Liver Transplantation, Diagnostic Biomarker, Hepatocellular Carcinoma

01/27

01/38

Recruiting

N/A

8000

Europe

Johann Wolfgang Goethe University Hospital, Kerckhoff Klinik, Johannes Gutenberg University Mainz

Heart Failure, Cardiomyopathies, Inflammatory Disease, Coronary Artery Disease, Chronic Kidney Diseases

02/30

02/30

Recruiting

N/A

30

Europe

Cardiovalve Transfemoral Mitral Valve

Cardiovalve Ltd., Meditrial Europe Ltd., Meditrial SrL

Mitral Regurgitation, Mitral Valve Disease

12/24

12/29