| Miller, Jeffrey |
| Completed | N/A | 140 | Canada, US | DrugSorb-ATR system, Sorbent hemoperfusion system, Sham comparator | CytoSorbents, Inc | Hemorrhage, Surgical, Blood Loss, Surgical, Blood Loss, Postoperative, Hemorrhage Postoperative | 08/23 | 08/23 | | |
| Active, not recruiting | N/A | 400 | US | SpineJack system, Balloon kyphoplasty, Vertebroplasty | Stryker Instruments, Talosix | Osteoporotic Vertebral Compression Fractures | 12/24 | 12/24 | | |
STAND, NCT04835428: - Study of the AGN1 LOEP SV Kit Compared to PMMA in Patients With Vertebral Compression Fractures |
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| Recruiting | N/A | 408 | US | Treatment Group: AGN1 LOEP SV Kit, Control Group: PMMA bone cement | AgNovos Healthcare, LLC | Vertebral Compression Fracture, Compression Fracture, Vertebral Compression | 12/25 | 12/27 | | |
| Nowak-Wegrzyn, Anna |
| Active, not recruiting | 1/2 | 264 | US, RoW | STMC-103H, Placebo | Siolta Therapeutics, Inc. | Atopic Dermatitis, Type 1 Hypersensitivity | 11/24 | 10/25 | | |
| Reddy, Vivek Y |
| Terminated | 3 | 248 | US, RoW | Coherex WaveCrest® Left Atrial Appendage Occlusion System, Watchman® LAA Closure Device | Coherex Medical, Biosense Webster, Inc. | Stroke | 12/23 | 12/23 | | |
NCT05026866: A Donanemab (LY3002813) Prevention Study in Participants With Alzheimer's Disease (TRAILBLAZER-ALZ 3) |
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| Recruiting | 3 | 2600 | Japan, US | Donanemab, LY3002813, Placebo | Eli Lilly and Company | Alzheimer Disease | 11/27 | 11/27 | | |
| Recruiting | 2 | 300 | US | TS23 | Translational Sciences, Inc., University of Cincinnati, National Institute of Neurological Disorders and Stroke (NINDS), Medical University of South Carolina, University of Arizona | Ischemic Stroke | 07/27 | 12/27 | | |
| Terminated | N/A | 109 | US | MFAM | Vivek Reddy, Biosense Webster, Inc. | Paroxysmal Atrial Fibrillation, Persistent Atrial Fibrillation | 10/22 | 10/22 | | |
ADVENT, NCT04612244: The FARAPULSE PIVOTAL Trial PFA System vs SOC Ablation for Paroxysmal Atrial Fibrillation |
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| Active, not recruiting | N/A | 900 | US | FARAPULSE Pulsed Field Ablation System, RadioFrequency and Cryoballoon Ablation | Farapulse, Inc. | Paroxysmal Atrial Fibrillation | 06/23 | 03/24 | | |
| Recruiting | N/A | 206 | US | cryoablation procedure | Adagio Medical | Sustained VT | 12/25 | 03/26 | | |
| Recruiting | N/A | 435 | Europe, Canada, US, RoW | Pulsed Field Ablation | Abbott Medical Devices | Atrial Arrhythmia, Atrial Fibrillation, Paroxysmal Atrial Fibrillation, Persistent Atrial Fibrillation | 01/26 | 01/26 | | |
| Recruiting | N/A | 300 | US | OPTIMIZER® Integra CCM-D System (Treatment Arm) | Impulse Dynamics | Heart Failure, Heart Failure With Reduced Ejection Fraction, Implantable Defibrillator User, CCM Therapy, Non-ischemic Cardiomyopathy, Ischemic Cardiomyopathy, Sudden Cardiac Arrest, Arrhythmias, Cardiac, Ventricular Tachycardia, Ventricular Fibrillation | 06/24 | 12/25 | | |
CorCinch-HF, NCT04331769: Clinical Evaluation of the AccuCinch® Ventricular Restoration System in Patients Who Present With Symptomatic Heart Failure With Reduced Ejection Fraction (HFrEF): The CORCINCH-HF Study |
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| Recruiting | N/A | 400 | Europe, US, RoW | AccuCinch Ventricular Restoration System, Guideline-Directed Medical Therapy | Ancora Heart, Inc. | Heart Failure With Reduced Ejection Fraction (HFrEF), Dilated Cardiomyopathy | 06/24 | 12/30 | | |
| Recruiting | N/A | 2650 | Europe, Canada, Japan, US, RoW | Left Atrial Appendage Occlusion (Amplatzer Amulet LAA Occluder), Amplatzer Amulet LAA Occluder, Non-Vitamin K Oral Antagonists, NOAC | Abbott Medical Devices | Atrial Fibrillation, Stroke, Bleeding | 08/27 | 08/30 | | |
ADVANTAGE AF, NCT05443594: A Prospective Single Arm Open Label Study of the FARAPULSE Pulsed Field Ablation System in Subjects With Persistent Atrial Fibrillation |
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| Active, not recruiting | N/A | 669 | Europe, Canada, US | Phase 1: FARAPULSE Ablation System, Phase 2: FARAPULSE Ablation System | Boston Scientific Corporation | Persistent Atrial Fibrillation | 03/25 | 03/25 | | |
MODULAR ATP, NCT04798768: Effectiveness of the EMPOWER™ Modular Pacing System and EMBLEM™ Subcutaneous ICD to Communicate Antitachycardia Pacing |
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| Active, not recruiting | N/A | 297 | Europe, Canada, US, RoW | mCRM Therapy System, Communication of S-ICD to Leadless Cardiac Pacemaker (LCP) | Boston Scientific Corporation | Tachycardia, Ventricular, Arrhythmia, Ventricular | 02/25 | 12/30 | | |
| Active, not recruiting | N/A | 481 | Europe, Canada, US, RoW | WATCHMAN LAAC Device Implant, Single Antiplatelet Therapy or No Therapy (Control) | Boston Scientific Corporation | Stroke | 12/25 | 12/25 | | |
INTERCEPT, NCT05723926: Carotid Implants for PreveNtion of STrokE ReCurrEnce From Large Vessel Occlusion in Atrial Fibrillation Patients Treated With Oral Anticoagulation |
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| Not yet recruiting | N/A | 2000 | NA | Vine Filter, Vine Embolic Protection System | Javelin Medical, Population Health Research Institute | Atrial Fibrillation, Oral Anticoagulation, Stroke, Implant | 12/28 | 10/30 | | |
| Lam, David CL |
| Recruiting | 1/2 | 360 | Europe, US | MCLA-158, petosemtamab, MCLA-158 +Pembrolizumab | Merus N.V., Chiltern International Inc., Q2 Solutions, Oncology Therapeutic Development (OTD), 4Clinics | Advanced/Metastatic Solid Tumors, Colorectal Cancer, Gastric Cancer, Gastroesophageal-junction Cancer, NSCLC, HNSCC, Head and Neck Squamous Cell Carcinoma | 06/24 | 06/25 | | |
| Active, not recruiting | 1/2 | 334 | Europe, Japan, US, RoW | TAK-788, AP32788 | Takeda | Carcinoma, Non-Small-Cell Lung | 03/25 | 03/25 | | |
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NCT05198284: Prospective Decision Impact Clinical Utility Trial of KidneyIntelX |
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| Active, not recruiting | N/A | 2000 | US | KidneyIntelX | Renalytix AI, Inc. | Diabetic Kidney Disease, Chronic Kidney Diseases, Chronic Kidney Disease Stage 1, Chronic Kidney Disease Stage 2, Chronic Kidney Disease Stage 3 | 12/23 | 11/26 | | |
NCT05762731: Screening for Lung Cancer in Subjects With Family History of Lung Cancer |
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| Recruiting | N/A | 1520 | RoW | Low dose CT thorax | The University of Hong Kong, The Queen Elizabeth Hospital, Kwong Wah Hospital, Hong Kong Sanatorium & Hospital | Lung Cancer | 12/24 | 12/25 | | |
| Contact, Central |
NCT03641560: A Safety and Efficacy Study of Enzalutamide in Indian Patients With Progressive Metastatic Castration-Resistant Prostate Cancer (mCRPC) Previously Treated With Docetaxel-Based Chemotherapy |
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| Completed | 4 | 52 | RoW | Enzalutamide, MDV3100, Xtandi, Androgen deprivation therapy (ADT) | Astellas Pharma Inc | Metastatic Castration Resistant Prostate Cancer | 02/24 | 02/24 | | |
NCT02294461: An Asian Study to Evaluate Efficacy and Safety of Oral Enzalutamide in Progressive Metastatic Prostate Cancer Participants |
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| Active, not recruiting | 3 | 395 | RoW | Enzalutamide, Xtandi, MDV3100, Placebo | Astellas Pharma Inc | Progressive Metastatic Prostate Cancer | 09/15 | 06/24 | | |
TAP, NCT05568888: Evaluation of BE1116 in Patients With Traumatic Injury and Acute Major Bleeding to Improve Survival ( Study ) |
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| Recruiting | 3 | 8000 | Europe, US, RoW | BE1116, 4-Factor Prothrombin Complex, Kcentra®, Beriplex®, Placebo | CSL Behring | Traumatic Injury | 09/26 | 09/26 | | |
NCT02430220: The Safety and Efficacy Study of Regorafenib (CT) Compared With Regorafenib (STIVARGA) in Patients With Solid Tumors |
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| Active, not recruiting | 2 | 152 | RoW | Regorafenib (CT), BAY 73-4506, Regorafenib (STIVARGA) | Cancer Centre of Monoclonal Therapy, LLC, Clinical Cancer Hospital, Bayer | Solid Tumors, Colorectal Cancer | 04/18 | 09/18 | | |
| Active, not recruiting | 2 | 100 | US | ALG-055009, Placebo | Aligos Therapeutics | NASH, MASH, Metabolic Dysfunction-Associated Steatohepatitis, Nonalcoholic Steatohepatitis | 11/24 | 12/24 | | |
PRL-02-1001, NCT04729114: Open-label, Multicenter Study of Intramuscular PRL-02 Depot in Patients With Advanced Prostate Cancer |
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| Recruiting | 1/2 | 100 | US | PRL-02 injection, prednisone, dexamethasone, docetaxel infusion | Astellas Pharma Global Development, Inc. | Prostate Cancer, mCRPC, mCSPC | 12/24 | 04/25 | | |
NCT06285214: Study of V117957 in Interstitial Cystitis/Bladder Pain Syndrome |
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| Recruiting | 1 | 44 | US | V117957, Placebo | Imbrium Therapeutics, Purdue Pharma LP | Interstitial Cystitis/Bladder Pain Syndrome | 06/26 | 06/26 | | |
NCT04285827: Safety of Single Doses of CSL889 in Adult Patients With Sickle Cell Disease |
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| Completed | 1 | 28 | Europe, US | CSL889 | CSL Behring | Sickle Cell Disease | 07/23 | 07/23 | | |
NCT06364696: A Study to Find a Suitable Dose of ASP4396 in Adults With Solid Tumors |
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| Recruiting | 1 | 175 | US | ASP4396 | Astellas Pharma Inc | Solid Tumor | 04/27 | 04/27 | | |
NCT06248086: A Study to Find a Suitable Dose of ASP2802 in People With CD20-positive B-cell Lymphomas |
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| Recruiting | 1 | 21 | RoW | ASP2802, MACT, MA-20, ASP101G, MicAbody | Astellas Pharma Global Development, Inc. | B-cell Lymphoma | 06/26 | 08/31 | | |
| Recruiting | 1 | 229 | US | ASP1012, Pembrolizumab | Astellas Pharma Global Development, Inc. | Solid Tumor | 06/29 | 06/29 | | |
NCT06024642: Study of V117957 in Overactive Bladder Syndrome |
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| Completed | 1 | 51 | US | V117957, Placebo | Imbrium Therapeutics, Purdue Pharma LP | Overactive Bladder Syndrome | 05/24 | 05/24 | | |
| Completed | N/A | 1332 | US | | Shire | Hunter Syndrome | 02/23 | 02/23 | | |
| Recruiting | N/A | 1257 | US | | Shire | Gaucher Disease | 01/25 | 01/25 | | |
OPTION-VMS, NCT06049797: A Study Following Women in Menopause Treated With a Non-hormonal Therapy for Hot Flashes and Night Sweats |
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| Recruiting | N/A | 1000 | US | Fezolinetant, ESN364, VEOZAH, Paroxetine, Citalopram, Escitalopram, Desvenlafaxine, Venlafaxine, Gabapentin, Clonidine, Pregabalin, Oxybutynin, Any other SSRI/SNRI not already specified, Any other non-hormonal pharmacologic therapy prescribed for the treatment of VMS not included in a category above | Astellas Pharma Global Development, Inc. | Hot Flashes | 09/25 | 09/25 | | |
NCT03971253: Japan Post-Marketing Surveillance for Peficitinib to Assess Safety and Effectiveness in the Patients With Rheumatoid Arthritis |
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| Recruiting | N/A | 3000 | Japan | Peficitinib, ASP015K, Smyraf | Astellas Pharma Inc | Rheumatoid Arthritis (RA) | 12/25 | 12/25 | | |
NCT05886348: The Evaluation of Safety and Myopia Progression Control Using Novel Spectacle Lens |
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| Recruiting | N/A | 285 | RoW | Model-A Novel spectacle lens, Model-B Novel spectacle lens, Single vision spectacle lens | HOYA Lens Thailand LTD. | Myopia | 05/26 | 05/27 | | |
NCT06011954: A Study to Survey Adults in South Korea With Cancer Who Receive PADCEV Injection |
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| Recruiting | N/A | 235 | RoW | Enfortumab Vedotin, PADCEV, ASG-22CE | Astellas Pharma Korea, Inc., Seagen Inc. | Urothelial Cancer | 07/27 | 07/27 | | |
| Levy, Carol |
MKC-TI-193, NCT05904743: INHALE-3: Afrezza® Combined With Insulin Degludec Versus Usual Care in Adults With Type 1 Diabetes |
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| Active, not recruiting | 4 | 141 | US | Afrezza, Technosphere Insulin, insulin degludec, Rapid-acting Insulin Analog, any FDA approved Rapid-acting Insulin Analog, Basal Insulin, any FDA approved Basal Insulin | Mannkind Corporation, Jaeb Center for Health Research | Diabetes Mellitus, Type 1 | 06/24 | 10/24 | | |
NCT04905628: Performance of the Dexcom Continuous Glucose Monitoring (CGM) System in Pregnant Women With Diabetes Mellitus |
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| Recruiting | N/A | 100 | US | Dexcom CGM System | DexCom, Inc. | Diabetes Mellitus | 03/22 | 04/22 | | |
NCT05403502: Safety Evaluation of an Advanced Hybrid Closed Loop System Using Lyumjev With the Tandem t:Slim X2 Insulin Pump With Control-IQ Technology in Adults, Adolescents and Children With Type 1 Diabetes |
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| Completed | N/A | 183 | US | t:slim X2 insulin pump with Control-IQ technology 1.5 | Tandem Diabetes Care, Inc., Eli Lilly and Company, Jaeb Center for Health Research | Type 1 Diabetes | 08/23 | 08/23 | | |
2IQP, NCT05785832: A Randomized Trial Evaluating Control-IQ Technology in Adults With Type 2 Diabetes |
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| Active, not recruiting | N/A | 335 | Canada, US | t:slim X2 insulin pump with Control-IQ technology 1.5 and Dexcom G6 CGM, Standard Therapy plus continuous glucose monitoring (CGM) | Tandem Diabetes Care, Inc., Jaeb Center for Health Research | Type 2 Diabetes Treated With Insulin | 09/24 | 09/24 | | |
CGM-DTx, NCT06111508: The Effect and Safety of a Novel CGM-Based Titration Algorithm for Basal Insulin in T2DM Participants. |
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| Recruiting | N/A | 30 | US | Continuous Glucose Monitoring (CGM)-based titration algorithm implemented in DiAs, Degludec | University of Virginia, Novo Nordisk A/S | Type 2 Diabetes | 08/24 | 08/24 | | |
| Nagula, Satish |
NCT04404101: Evaluation of Pancreatic Cystic Lesions Via EUS-guided Fine Needle Aspiration With and Without Micro Forceps Biopsies |
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| Recruiting | N/A | 300 | US | 1). EUS-FNA plus MFB, 2). EUS-FNA Alone | University of Colorado, Denver, US Endoscopy | Pancreatic Cyst | 04/25 | 04/25 | | |
| Morrell, Martha J |
| Active, not recruiting | 3 | 100 | US | Responsive stimulation, Sham stimulation | NeuroPace | Epilepsy, Idiopathic Generalized Epilepsy, Generalized Tonic Clonic Seizure | 06/25 | 12/26 | | |
| Recruiting | 2 | 24 | US | RNS System | NeuroPace, National Institute of Neurological Disorders and Stroke (NINDS), University of Florida | Epilepsy, Lennox Gastaut Syndrome, Lennox-Gastaut Syndrome, Intractable, Seizures, Seizures, Generalized | 05/26 | 12/26 | | |
| Active, not recruiting | N/A | 375 | US | RNS System | NeuroPace | Epilepsy | 12/23 | 01/26 | | |
| Recruiting | N/A | 200 | US | RNS System | NeuroPace | Epilepsy, Partial Seizure, Neurostimulator; Complications, Drug Resistant Epilepsy, Focal Epilepsy | 07/26 | 12/27 | | |
| Ahuja, Mukesh |
| Recruiting | N/A | 160 | US | InSpace Subacromial Tissue Spacer | Stryker Endoscopy | Rotator Cuff Tears | 04/24 | 04/25 | | |
NCT02501733: Medacta GMK Sphere® Multicenter Post-Market Outcomes Study |
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| Active, not recruiting | N/A | 260 | US | Medacta GMK Sphere® Medial Knee Prosthesis, Total Knee Arthroplasty, Total Knee Prosthesis | Medacta USA | Osteoarthritis | 07/24 | 12/24 | | |
STAND, NCT04835428: - Study of the AGN1 LOEP SV Kit Compared to PMMA in Patients With Vertebral Compression Fractures |
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| Recruiting | N/A | 408 | US | Treatment Group: AGN1 LOEP SV Kit, Control Group: PMMA bone cement | AgNovos Healthcare, LLC | Vertebral Compression Fracture, Compression Fracture, Vertebral Compression | 12/25 | 12/27 | | |
NCT03211663: Performance of MOTO Medial® Unicompartmental Knee Arthroplasty |
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| Active, not recruiting | N/A | 269 | US | MOTO Medial® UKA, Medial Unicondylar Knee Replacement | Medacta USA | Knee Osteoarthritis, Knee Arthritis, Knee Pain Chronic | 08/25 | 12/25 | | |
NCT02583113: Bilateral Total Knee Arthroplasty vs Unicompartment Arthroplasty Retrospective and Clinical Outcome Study |
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| Withdrawn | N/A | 200 | US | Total and Unicompartment Knee Replacement, TKA UKA | Medacta USA | Osteoarthritis | 12/26 | 12/26 | | |
| DiMaio, Christopher J |
PROTACT, NCT01676259: A Phase 2 Study of siG12D LODER in Combination With Chemotherapy in Patients With Locally Advanced Pancreatic Cancer |
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| Recruiting | 2 | 80 | US, RoW | siG12D-LODER, Gemcitabine+nab-Paclitaxel, Chemotherapy, Folfirinox | Silenseed Ltd | Pancreatic Ductal Adenocarcinoma, Pancreatic Cancer | 10/22 | 08/23 | | |
| Busse, Paula |
PANDA, NCT05347771: Prevention of Asthma Exacerbations Using Dupilumab in Urban Children and Adolescents |
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| Recruiting | 2 | 240 | US | Dupilumab, Dupixent, IL4Ra mAb, Placebo, Placebo for Dupilumab | National Institute of Allergy and Infectious Diseases (NIAID), Childhood Asthma in Urban Settings (CAUSE), Regeneron Pharmaceuticals, Rho Federal Systems Division, Inc. | Asthma | 08/25 | 12/25 | | |
NCT04583007: Expanded Access for the Prevention of Acute Attacks of 1) Hereditary Angioedema (HAE) in Children and 2) Non-histaminergic Angioedema With Normal C1-Inhibitor (C1-INH) in Teenagers and Adults |
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| No Longer Available | N/A | | Europe, Canada, US | Lanadelumab 150 mg, TAK-743, SHP643, DX-2930, Lanadelumab 300 mg | Shire, Takeda Development Center Americas, Inc. | Hereditary Angioedema (HAE), Angioedema | | | | |
| Leacy, Reade De |
| Recruiting | 3 | 400 | US | SB-01 For Injection, Sham Needle | Spine BioPharma, Inc, MCRA | Lumbar Degenerative Disc Disease | 12/24 | 06/25 | | |
| Recruiting | N/A | 26 | US | Vertebral Body Augmentation, Manual Surgical Instruments | Lenoss Medical, MCRA, LLC | Vertebral Body Compression Fracture(s) | 08/22 | 12/22 | | |
NCT04129125: The Imperative Trial: Treatment of Acute Ischemic Stroke With the Zoom Reperfusion System |
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| Recruiting | N/A | 262 | US | Zoom Reperfusion System | Imperative Care, Inc. | Ischemic Stroke, Acute Stroke | 07/24 | 08/24 | | |
STAND, NCT04835428: - Study of the AGN1 LOEP SV Kit Compared to PMMA in Patients With Vertebral Compression Fractures |
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| Recruiting | N/A | 408 | US | Treatment Group: AGN1 LOEP SV Kit, Control Group: PMMA bone cement | AgNovos Healthcare, LLC | Vertebral Compression Fracture, Compression Fracture, Vertebral Compression | 12/25 | 12/27 | | |
CLASS, NCT05636124: Kaneka iED Coil System for the Treatment of Wide Necked Ruptured and Unruptured Intracranial Aneurysms |
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| Recruiting | N/A | 50 | US | Kaneka i-ED coil | Icahn School of Medicine at Mount Sinai, Kaneka Corporation | Intracranial Aneurysms, Wide Neck Intracranial Aneurysms | 07/25 | 07/25 | | |
STERLING, NCT03642639: A Study to Look at Performance of MICRUSFRAME and GALAXY Coils for the Treatment of Intracranial Aneurysms |
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| Recruiting | N/A | 850 | Europe, US | MICRUSFRAME and GALAXY coils | Cerenovus, Part of DePuy Synthes Products, Inc. | Aneurysms | 12/25 | 06/26 | | |
| Harb, Armand |
| Active, not recruiting | 3 | 100 | US | Responsive stimulation, Sham stimulation | NeuroPace | Epilepsy, Idiopathic Generalized Epilepsy, Generalized Tonic Clonic Seizure | 06/25 | 12/26 | | |
| Completed | N/A | 1057 | Canada, US | NeuroBlate System | Monteris Medical | Metastatic Brain Tumor, Primary Brain Tumor, Epileptic/Seizure Foci, Movement Disorders | 09/23 | 09/23 | | |
| Deeba, Serina |
STAND, NCT04835428: - Study of the AGN1 LOEP SV Kit Compared to PMMA in Patients With Vertebral Compression Fractures |
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| Recruiting | N/A | 408 | US | Treatment Group: AGN1 LOEP SV Kit, Control Group: PMMA bone cement | AgNovos Healthcare, LLC | Vertebral Compression Fracture, Compression Fracture, Vertebral Compression | 12/25 | 12/27 | | |
| Doshi, Amish |
STAND, NCT04835428: - Study of the AGN1 LOEP SV Kit Compared to PMMA in Patients With Vertebral Compression Fractures |
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| Recruiting | N/A | 408 | US | Treatment Group: AGN1 LOEP SV Kit, Control Group: PMMA bone cement | AgNovos Healthcare, LLC | Vertebral Compression Fracture, Compression Fracture, Vertebral Compression | 12/25 | 12/27 | | |
| Szentirmai, Oszkar |
STAND, NCT04835428: - Study of the AGN1 LOEP SV Kit Compared to PMMA in Patients With Vertebral Compression Fractures |
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| Recruiting | N/A | 408 | US | Treatment Group: AGN1 LOEP SV Kit, Control Group: PMMA bone cement | AgNovos Healthcare, LLC | Vertebral Compression Fracture, Compression Fracture, Vertebral Compression | 12/25 | 12/27 | | |
RESTORE, NCT04803214: ReActiv8 Stimulation Therapy vs Optimal Medical Management: A Randomized Evaluation |
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| Active, not recruiting | N/A | 228 | US | ReActiv8 | Mainstay Medical | Chronic Low-back Pain | 07/25 | 07/25 | | |
