| Rodes-Cabau, Josep |
ANDES, NCT03568890: Short-Term Anticoagulation Versus Antiplatelet Therapy for Preventing Device Thrombosis Following Left Atrial Appendage Closure |
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| Recruiting | 4 | 510 | Canada | Rivaroxaban, dabigatran, apixaban, or edoxaban, Clopidogrel -75 mg/day, Low dose aspirin -80 to 125 mg/day- | Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec | Left Atrial Appendage Closure, Thrombosis, Stroke, TIA, Bleeding | 12/25 | 09/26 | | |
NCT03383445: Transcatheter Aortic Valve Replacement Versu Surgical Aortix Valve Replacement for Treating Elderly Patients With Severe Aortic Stenosis and Small Aortic Annuli: A Prospective Randomized Study The VIVA Trial |
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| Active, not recruiting | N/A | 300 | Canada | Edwards, CoreValve, Acurate neo, Standard | Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec | Degenerative Aortic Valve Disease, Aortic Stenosis, Aortic Regurgitation | 10/23 | 05/24 | | |
| Recruiting | N/A | 200 | Europe, Canada, US | AVP III | Abbott Medical Devices | Paravalvular Aortic Regurgitation | 07/25 | 06/26 | | |
PROMOTE, NCT04139616: Prospective Validation of a Pre-Specified Algorithm for the Management of Conduction Disturbances Following TAVR |
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| Recruiting | N/A | 2000 | Canada | | Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec | Conduction Disturbances, Transcatheter Aortic Valve Replacement, Permanent Pacemaker Implantation | 12/24 | 02/25 | | |
HALTI, NCT04475510: Discontinuation of Antithrombotic Treatment Following Patent Foramen Ovale Closure in Young Patients With Cryptogenic Stroke |
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| Recruiting | N/A | 100 | Canada | Antiplatelet treatment discontinuation | Josep Rodes-Cabau | Patent Foramen Ovale, Ischemic Stroke, Bleeding Ulcer | 06/25 | 08/32 | | |
| Recruiting | N/A | 50 | Canada, US | Cephea Mitral Valve System | Abbott Medical Devices | Mitral Regurgitation | 03/26 | 03/31 | | |
ECHOCATH, NCT05459233: Valve Hemodynamic Optimization Based on Doppler-Echocardiography vs Catheterization Measurements Following ViV TAVR |
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| Recruiting | N/A | 310 | Canada, US | Doppler-echocardiography, Invasive hemodynamic measurements | Institut universitaire de cardiologie et de pneumologie de Québec, University Laval | Aortic Valve Stenosis, Aortic Valve Regurgitation, Prosthesis Failure | 09/25 | 09/29 | | |
| Recruiting | N/A | 650 | Europe, Canada, Japan, US, RoW | Medtronic Evolut PRO+ TAVR System, or Evolut FX TAVR System, and guideline-directed management and therapy (GDMT) | Medtronic Cardiovascular | Moderate Aortic Valve Stenosis | 02/26 | 12/34 | | |
| Tremblay, Angelo |
NCT05417347: Full-fat Dairy Products, Body Weight Control and Metabolic Health |
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| Recruiting | N/A | 300 | Canada | Low-fat dairy products, Full-fat dairy products | Laval University | Obesity | 08/24 | 08/24 | | |
| Morin, Charles M |
| Completed | 2 | 70 | Canada | Probiotic formulation, Placebo | Lallemand Health Solutions | Sleep Disturbance, Sleep Patterns | 05/23 | 05/23 | | |
| Recruiting | N/A | 120 | Canada | Web-based cognitive-behavioral therapy for insomnia (CBT-I), Self-administered, Professionally-administered booster face-to-face CBT-I sessions | CHU de Quebec-Universite Laval, Canadian Institutes of Health Research (CIHR), Canadian Cancer Society (CCS) | Insomnia | 05/25 | 05/25 | | |
NCT03633305: Optimization of Insomnia Treatment in Primary Care |
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| Recruiting | N/A | 300 | Canada | Hypnotics, Online CBT, Face-to-face CBT | Laval University, Canadian Institutes of Health Research (CIHR) | Insomnia Disorder | 12/23 | 12/23 | | |
NCT06779149: Efficacy of CBT-I and Lemborexant Medication for Different Subtypes of Chronic Insomnia |
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| Not yet recruiting | N/A | 90 | NA | Cognitive Behavioral Treatment for Insomnia (CBT-I), Lemborexant, Placebo | Laval University, Toronto Metropolitan University, The Royal Ottawa Mental Health Centre | Insomnia Disorder | 02/27 | 02/27 | | |
| Champagne, Jean |
| Active, not recruiting | 4 | 1284 | Europe, Canada, RoW | Rivaroxaban, Xarelto, Acetylsalicylic acid, Aspirin, ASA | Ottawa Heart Institute Research Corporation, Canadian Institutes of Health Research (CIHR), Bayer, Biotronik Canada Inc | Atrial Fibrillation, Stroke | 07/25 | 08/25 | | |
AVANT GUARD, NCT06096337: Pulsed Field Ablation (PFA) Vs Anti-Arrhythmic Drug (AAD) Therapy As a First Line Treatment for Persistent Atrial Fibrillation |
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| Recruiting | N/A | 520 | Europe, Canada, US, RoW | FARAPULSE™ Pulsed Field Ablation (PFA) System, Anti-Arrhythmic Drug (AAD): Flecainide, Sotalol, Propafenone, Dofetilide, and Dronedarone | Boston Scientific Corporation | Persistent Atrial Fibrillation | 12/25 | 12/27 | | |
| Recruiting | N/A | 220 | Canada, US, RoW | FARAPULSE™ Pulsed Field Ablation System, FARAWAVE™ Pulsed Field Ablation Catheter | Boston Scientific Corporation | Paroxysmal Atrial Fibrillation | 10/28 | 10/29 | | |
| Active, not recruiting | N/A | 617 | Europe, Canada, Japan, US, RoW | Wide Circumferential Pulmonary Vein Antrum Isolation (PVAI), Pulmonary Vein Antrum Isolation Plus Driver Ablation (PVAI+drivers), Pulmonary Vein Antrum Isolation Plus Box Isolation of Posterior Wall (PVAI+box) | McGill University Health Centre/Research Institute of the McGill University Health Centre, Montreal Heart Institute | Atrial Fibrillation | 09/27 | 12/27 | | |
ADVANTAGE AF, NCT05443594: A Prospective Single Arm Open Label Study of the FARAPULSE Pulsed Field Ablation System in Subjects with Persistent Atrial Fibrillation |
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| Active, not recruiting | N/A | 669 | Europe, Canada, US | Phase 1: FARAPULSE Ablation System, Phase 2: FARAPULSE Ablation System | Boston Scientific Corporation | Persistent Atrial Fibrillation | 03/25 | 03/25 | | |
| Recruiting | N/A | 4000 | Europe, Canada, US | WATCHMAN device | Hamilton Health Sciences Corporation, McMaster University, Population Health Research Institute, Boston Scientific Corporation | Atrial Fibrillation, Stroke, Ischemic, Systemic Embolism | 09/29 | 12/29 | | |
| Bapat, Vinayak |
| Recruiting | N/A | 1247 | Europe, Canada, US | Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System | Edwards Lifesciences | Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation | 01/25 | 04/30 | | |
| Recruiting | N/A | 225 | US | Medtronic TAV, Edwards TAV | Medtronic Cardiovascular | Aortic Stenosis | 03/29 | 07/33 | | |
| Recruiting | N/A | 15 | US | AltaValve | 4C Medical Technologies, Inc. | Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Incompetence, Mitral Valve Regurgitation, Mitral Incompetence | 09/25 | 09/25 | | |
| Recruiting | N/A | 500 | Europe, Canada, US | MitraClip™ device implantation, Mitral Valve Repair Surgery | Abbott Medical Devices | Mitral Valve Regurgitation | 04/26 | 04/34 | | |
APOLLO, NCT03242642: Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation. |
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| Recruiting | N/A | 1056 | Europe, Canada, US | Medtronic Intrepid Transcatheter Mitral Valve Replacement System (TMVR) | Medtronic Cardiovascular | Mitral Valve Regurgitation | 10/26 | 09/36 | | |
| Recruiting | N/A | 6500 | Europe, Canada, US | AtriClip LAA Exclusion System | AtriCure, Inc., Population Health Research Institute | Ischemic Stroke, Systemic Embolism | 12/31 | 04/32 | | |
| Gagnon, Marie-Pierre |
| Recruiting | N/A | 120 | Canada | Web-based cognitive-behavioral therapy for insomnia (CBT-I), Self-administered, Professionally-administered booster face-to-face CBT-I sessions | CHU de Quebec-Universite Laval, Canadian Institutes of Health Research (CIHR), Canadian Cancer Society (CCS) | Insomnia | 05/25 | 05/25 | | |
| Dagenais, Francois |
| Recruiting | 4 | 766 | Canada, US | Evolocumab, Repatha®, Placebo, Control | Unity Health Toronto, Applied Health Research Centre | Coronary Artery Bypass Graft Surgery, Atherosclerosis, Vein Occlusion | 12/23 | 12/23 | | |
| Recruiting | N/A | 1247 | Europe, Canada, US | Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System | Edwards Lifesciences | Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation | 01/25 | 04/30 | | |
| Recruiting | N/A | 282 | Canada, US | Hypothermic circulatory arrest | Ottawa Heart Institute Research Corporation | Thoracic Aortic Disease | 02/25 | 09/25 | | |
| Biertho, Laurent |
| Recruiting | N/A | 120 | Canada | Standard Duodenal Switch, BPD-DS, Single Anastomosis Duodenal Switch, SADI | Laval University, Institut universitaire de cardiologie et de pneumologie de Québec, University Laval | Obesity, Morbid Obesity | 09/25 | 09/26 | | |
NCT04627103: Procedure for Duodenal-Ileal Diversion With a Sleeve Gastrectomy for Patients With Obesity and Type 2 Diabetes Mellitus |
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| Active, not recruiting | N/A | 18 | Canada | Self Forming Magnetic (SFM) Anastomosis System | GI Windows, Inc. | Obesity, Type 2 Diabetes Mellitus | 07/24 | 11/24 | | |
REMISSION, NCT02390973: Surgery Versus Best Medical Management for the Long Term Remission of Type 2 Diabetes and Related Diseases |
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| Recruiting | N/A | 408 | Canada | Sleeve Gastrectomy, Roux-en-Y Gastric Bypass, Biliopancreatic Diversion with Duodenal Switch, Medical management | Laval University, Johnson & Johnson Medical Products, Institut universitaire de cardiologie et de pneumologie de Québec, University Laval | Bariatric Surgery Candidate, Diabetes | 03/25 | 03/29 | | |
NCT05242835: Management of Sleeve Gastrectomy Failure Using Single-anastomosis Metabolic Surgery |
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| Recruiting | N/A | 151 | Canada | Standard duodenal switch, BPD-DS, Single-anastomosis duodenal switch, SADI | Laval University, Institut universitaire de cardiologie et de pneumologie de Québec, University Laval | Obesity, Obesity, Morbid | 01/27 | 03/27 | | |
| Tremblay, Hugo |
| Recruiting | 4 | 766 | Canada, US | Evolocumab, Repatha®, Placebo, Control | Unity Health Toronto, Applied Health Research Centre | Coronary Artery Bypass Graft Surgery, Atherosclerosis, Vein Occlusion | 12/23 | 12/23 | | |
| Withdrawn | 2 | 206 | NA | Warfarin, Coumadin, Dabigatran, Pradaxa, Rivaroxaban, Xarelto, Apixaban, Eliquis, Edoxaban, Lixiana | Laval University | Anticoagulant-induced Bleeding | 01/23 | 03/23 | | |
| Recruiting | N/A | 15 | Europe, Canada, RoW | VenTouch System | Mardil Medical | Functional Mitral Regurgitation | 05/21 | 12/23 | | |
NCT03302195: Optimal Cardiopulmonary Bypass and Anticoagulation Management Strategies in Obese Patients Undergoing Cardiac Surgery |
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| Recruiting | N/A | 410 | Canada | Heparin, cardiopulmonary bypass pump flow rate | Laval University, Centre de Recherche de l'Institut Universitaire de Cardiologie et de Pneumologie de Quebec | Cardiopulmonary Bypass, Obesity | 12/24 | 12/27 | | |
| Genereux, Philippe |
NCT02661451: Transcatheter Aortic Valve Replacement to UNload the Left Ventricle in Patients With ADvanced Heart Failure (TAVR UNLOAD) |
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| Active, not recruiting | N/A | 178 | Europe, Canada, US | SAPIEN 3 THV, Optimal Heart Failure Therapy | Cardiovascular Research Foundation, New York, Cardialysis BV, Avania | Aortic Valve Stenosis | 02/23 | 02/25 | | |
| Recruiting | N/A | 1247 | Europe, Canada, US | Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System | Edwards Lifesciences | Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation | 01/25 | 04/30 | | |
CorCinch-HF, NCT04331769: Clinical Evaluation of the AccuCinch® Ventricular Restoration System in Patients Who Present with Symptomatic Heart Failure with Reduced Ejection Fraction (HFrEF): the CORCINCH-HF Study |
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| Recruiting | N/A | 400 | Europe, US, RoW | AccuCinch Ventricular Restoration System, Guideline-Directed Medical Therapy | Ancora Heart, Inc. | Heart Failure with Reduced Ejection Fraction (HFrEF), Dilated Cardiomyopathy | 12/26 | 12/30 | | |
| Active, not recruiting | N/A | 50 | US | Shortcut | Pi-cardia | Valve-in-valve Procedures, Aortic Stenosis, Coronary; Obstruction | 04/25 | 09/25 | | |
NCT03523416: Early Feasibility Study - Edwards APTURE Transcatheter Shunt System |
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| Active, not recruiting | N/A | 71 | US | Transcatheter Atrial Shunt System | Edwards Lifesciences | Heart Failure | 12/23 | 11/28 | | |
NCT06680427: Siegel™ Transcatheter Aortic Valve Replacement System (TAVR) Early Feasibility Study |
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| Recruiting | N/A | 15 | US | Siegel Transcatheter Aortic Valve (TAVR) | MiRus | Aortic Stenosis Symptomatic | 01/26 | 01/26 | | |
| Recruiting | N/A | 15 | US | AltaValve | 4C Medical Technologies, Inc. | Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Incompetence, Mitral Valve Regurgitation, Mitral Incompetence | 09/25 | 09/25 | | |
| Recruiting | N/A | 500 | Europe, Canada, US | MitraClip™ device implantation, Mitral Valve Repair Surgery | Abbott Medical Devices | Mitral Valve Regurgitation | 04/26 | 04/34 | | |
APOLLO, NCT03242642: Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation. |
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| Recruiting | N/A | 1056 | Europe, Canada, US | Medtronic Intrepid Transcatheter Mitral Valve Replacement System (TMVR) | Medtronic Cardiovascular | Mitral Valve Regurgitation | 10/26 | 09/36 | | |
| Halperin, Ilana |
| Recruiting | 2 | 42 | Canada | Dex4/ dextrose, Glucose beverage | Sunnybrook Health Sciences Centre | Diabetes, Gestational | 12/24 | 12/24 | | |
| Completed | N/A | 345 | Canada | Home-based Physical Activity Program with Health Coach, Home-based Low-GI Diet Program with Health Coach | Women's College Hospital, The Lawson Foundation, Diabetes Canada, Unity Health Toronto, Sunnybrook Health Sciences Centre, Mount Sinai Hospital, Canada, Michael Garron Hospital, Canadian Institutes of Health Research (CIHR), Scarborough Rouge Hospital, J.P. Bickell Foundation | Diabetes | 10/22 | 01/23 | | |
NCT04098679: Childhood Adiposity and Neurodevelopmental Outcomes Among Offspring of Women With Type 1 Diabetes (CONCEPTT Kids) |
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| Recruiting | N/A | 174 | Canada | | University of Calgary, SRI International, Juvenile Diabetes Research Foundation | Neurologic Disorder, Adiposity | 12/23 | 12/23 | | |
| Active, not recruiting | N/A | 227 | Canada | Resource bank, ePlatform, Health coach | McGill University Health Centre/Research Institute of the McGill University Health Centre, The Lawson Foundation | Gestational Diabetes | 06/24 | 06/24 | | |
| Recruiting | N/A | 500 | Canada | Diabetes Exercise and Healthy Lifestyle Program, Outpatient care | Sunnybrook Health Sciences Centre, University Health Network, Toronto, University of Toronto | Type 2 Diabetes, PreDiabetes | 12/25 | 12/26 | | |
| Active, not recruiting | N/A | 94 | Canada, RoW | Tandem t:slim X2 insulin pump with Control IQ technology | University of Calgary | Type 1 Diabetes Mellitus, Pregnancy Related, Glucose Metabolism Disorders, Metabolic Disease, Endocrine System Diseases | 01/25 | 03/25 | | |
| Lamy, Manon |
| Completed | 2 | 70 | Canada | Probiotic formulation, Placebo | Lallemand Health Solutions | Sleep Disturbance, Sleep Patterns | 05/23 | 05/23 | | |
NCT06281756: Cognitive Behavioral Therapy and Trazodone Effects on Sleep and Blood Pressure in Insomnia |
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| Recruiting | 1 | 600 | Canada, US | Cognitive Behavioral Treatment for Insomnia (CBT-I), Trazodone, Placebo | Milton S. Hershey Medical Center, National Heart, Lung, and Blood Institute (NHLBI) | Insomnia, Insomnia Chronic, Insomnia, Primary, Blood Pressure, Blood Pressure, High | 02/27 | 02/28 | | |
NCT03633305: Optimization of Insomnia Treatment in Primary Care |
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| Recruiting | N/A | 300 | Canada | Hypnotics, Online CBT, Face-to-face CBT | Laval University, Canadian Institutes of Health Research (CIHR) | Insomnia Disorder | 12/23 | 12/23 | | |
| Jacques, Frederic |
| Recruiting | 4 | 396 | Canada | a wearable adhesive cardiac monitoring device | St. Michael's Hospital, Toronto, Southlake Regional Health Centre, University Health Network, Toronto | Cardiac Arrhythmias, Atrial Fibrillation | 12/20 | 12/20 | | |
DEPOSITION, NCT03954314: - Decreasing Postoperative Blood Loss by Topical vs. Intravenous Tranexamic Acid in Open Cardiac Surgery |
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| Terminated | 3 | 3242 | Canada, RoW | Tranexamic Acid, Cyklokapron | Population Health Research Institute | Bleeding, Surgical Blood Loss, Seizures | 11/23 | 11/23 | | |
| Lemieux, Patricia |
PREDISPOSE, NCT04972955: Predicting Dysglycemia in Individuals With Gestational Diabetes Immediately Postpartum Using Continuous Glucose Monitoring |
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| Recruiting | N/A | 240 | Canada | Freestyle Libre 2 | University of Manitoba | Gestational Diabetes, Prediabetes; Complicating Pregnancy, Type 2 Diabetes, Pregnancy Related, Glucose Metabolism Disorders, Metabolic Disease, Endocrine System Diseases | 02/25 | 02/28 | | |
| Active, not recruiting | N/A | 94 | Canada, RoW | Tandem t:slim X2 insulin pump with Control IQ technology | University of Calgary | Type 1 Diabetes Mellitus, Pregnancy Related, Glucose Metabolism Disorders, Metabolic Disease, Endocrine System Diseases | 01/25 | 03/25 | | |
