Wits Reproductive Health and HIV Institute
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 11 Trials 
20 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Celum, Connie
NCT06446752: BIYELA - Bexsero Immunisation in Young Women in Africa

Not yet recruiting
3
1100
RoW
Bexsero, 4MenB-4C, Placebo, Saline
University of Washington, Bill and Melinda Gates Foundation, University of Witwatersrand, South Africa
Gonorrhea, Gonorrhea of Pharynx, Gonorrhea of Anus, Gonorrhea of Cervix
05/26
08/26
NCT04038060: The PrEP (Pre-exposure Prophylaxis) SMART Study

Completed
N/A
350
RoW
WhatsApp Group, 2-way SMS, Drug level feedback, Monthly counseling sessions
University of Washington, Wits Reproductive Health and HIV Institute, National Institute of Mental Health (NIMH)
HIV/AIDS
10/21
01/22
Okutuuka, NCT05388084: Peer Led Outreach to Engage Male Partners of Pregnant Women in Uganda ( Study)

Completed
N/A
150
RoW
Male peer engagement, SOC and delayed intervention
University of Washington, National Institute of Mental Health (NIMH)
Engagement, Patient, Male Peer Recruitment, HIV Testing, Linkage to Care
05/23
07/23
INSIGHT, NCT05746065: A Cohort for Evaluation of Open-label PrEP Use and PreP Preferences Among African Women

Completed
N/A
3087
RoW
PrEP, Truvada
University of Washington, Bill and Melinda Gates Foundation
HIV Infections
08/23
08/23
Sebe, Modulakgotla A
panTB-HM, NCT05686356: A Pan-TB Regimen Targeting Host and Microbe

Recruiting
2/3
352
RoW
Sutezolid, N-acetyl cysteine, NAC, Pretomanid, Bedaquiline, Rifafour
The Aurum Institute NPC, Ludwig-Maximilians - University of Munich, Stichting Katholieke Universiteit, Wits Health Consortium (Pty) Ltd, Instituto Nacional de Saúde, Mozambique, National Institute for Medical Research, Tanzania, University of Stellenbosch, Sequella, Inc., Global Alliance for TB Drug Development
Tuberculosis
09/25
09/25
AUR1-8-341, NCT05515042: Phase 2a Trial to Evaluate Safety and Immunogenicity of COVID-19 Vaccine Strategies in HIV-infected/Uninfected Adults.

Active, not recruiting
2
694
RoW
Ad26.COV2.S (VAC31518, JNJ-78436735) Vaccine, SARS-CoV-2 rS (CovovaxTM), BNT162b2 (Pfizer)
The Aurum Institute NPC, Coalition for Epidemic Preparedness Innovations
COVID-19
06/24
12/24
NCT05221502: Safety and Efficacy Evaluation of 4-month Regimen of OPC-167832, Delamanid and Bedaquiline in Participants With Drug-Susceptible Pulmonary TB

Completed
2
122
RoW
Delamanid + Bedaquiline + OPC-167832 10 mg, Delamanid + Bedaquiline + OPC-167832 30 mg, Delamanid + Bedaquiline + OPC-167832 90 mg, RHEZ
Otsuka Pharmaceutical Development & Commercialization, Inc., Bill and Melinda Gates Foundation
Pulmonary TB
04/24
05/24
DOLPHIN Moms, NCT05122026: Safety and Tolerability of 1 Month Daily (1HP) and 3 Months Weekly (3HP) Isoniazid and Rifapentine With Pharmacokinetics of Dolutegravir (DTG) in Pregnant People With HIV

Recruiting
1/2
252
RoW
Rifapentine, Priftin, Isoniazid, Winthrop Isoniazid
The Aurum Institute NPC, Johns Hopkins University, Weill Medical College of Cornell University, University of Washington
HIV Seropositivity, Pregnancy, Tuberculosis Infection
12/24
03/25
Venter, Francois
PICASSO, NCT06485154: Post-Injectable Cabotegravir Antiretroviral Salvage Strategy Options Trial

Active, not recruiting
4
100
RoW
TLD - Tenofovir Disoproxil Fumarate / Lamivudine / Dolutegravir, Acriptega
University of Witwatersrand, South Africa, Bill and Melinda Gates Foundation
HIV Prevention
06/26
08/26
AXIS, NCT06138600: Acceptability and Feasibility of Injectable Cabotegravir Pre-exposure Prophylaxis (PrEP) Versus Oral PrEP in Routine Care up to 15 Months in Private Pharmacies in South Africa

Active, not recruiting
3
200
RoW
Cabotegravir Injection [Apretude], Apretude, Tenofovir disoproxil fumarate / emtricitabine (or lamivudine), Tenemine
University of Witwatersrand, South Africa, ViiV Healthcare
HIV Infections
10/25
01/26
CoTeT, NCT05459532: A Randomised, Multi-centre, Double-blind, Phase 3 Study to Observe the Effectiveness, Safety and Tolerability of Molnupiravir Compared to Placebo Administered Orally to High-risk Adult Outpatients With Mild COVID-19 Receiving Local Standard of Care in South Africa

Recruiting
3
4000
RoW
Molnupiravir 200 mg
University of Witwatersrand, South Africa, Bill and Melinda Gates Foundation
COVID-19
07/24
07/27
NCT04746183: AGILE (Early Phase Platform Trial for COVID-19)

Hourglass Jan 2022 - Jun 2022 : Data from AGILE trial for COVID-19
Active, not recruiting
1/2
600
Europe, RoW
CST-2: EIDD-2801, MK-4482, Molnupiravir, CST-2: Placebo, Placebo, Nitazoxanide, VIR-7832, VIR-7831, Sotrovimab, CST-5: Placebo, Favipiravir, Lagevrio, Paxlovid, nirmatrelvir and ritonavir
University of Liverpool, University of Southampton, Liverpool School of Tropical Medicine, Liverpool University Hospitals NHS Foundation Trust, University of Cambridge
Covid19
07/25
07/25
ChaLOC, NCT05445713: A Cross-sectional, Observational Study to Characterise Long COVID-19 in an Urban Sample of South African Adults

Active, not recruiting
N/A
400
RoW
University of Witwatersrand, South Africa
Long COVID
10/24
11/24
Delany-Moretlwe, Sinead
HOPE II, NCT06436274: Efficacy of Human Papillomavirus (HPV) Vaccination to Prevent Infection Among Women Living With HIV.

Recruiting
4
750
RoW
GARDASIL®9, Menveo®/Menactra®
Massachusetts General Hospital, University of Witwatersrand, South Africa, Botswana Harvard Health Partnership, Ministry of Health, Rwanda, Fred Hutchinson Cancer Center, National Cancer Institute (NCI), Karolinska Institutet
Human Papilloma Virus, Hiv
04/26
06/27
HPTN 084, NCT03164564: Evaluating the Safety and Efficacy of Long-Acting Injectable Cabotegravir Compared to Daily Oral TDF/FTC for Pre-Exposure Prophylaxis in HIV-Uninfected Women

Active, not recruiting
3
3224
RoW
Oral CAB, Cabotegravir, Oral TDF/FTC, Tenofovir disoproxil fumarate/emtricitabine, Truvada, Placebo for oral CAB, Placebo for oral TDF/FTC, CAB LA, Cabotegravir long-acting injectable, Placebo for CAB LA
National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
11/20
11/24
NCT06446752: BIYELA - Bexsero Immunisation in Young Women in Africa

Not yet recruiting
3
1100
RoW
Bexsero, 4MenB-4C, Placebo, Saline
University of Washington, Bill and Melinda Gates Foundation, University of Witwatersrand, South Africa
Gonorrhea, Gonorrhea of Pharynx, Gonorrhea of Anus, Gonorrhea of Cervix
05/26
08/26
HVTN143, NCT05959707: Evaluating the Safety, Tolerability, and Pharmacokinetics of Monoclonal Antibodies in Healthy Participants

Suspended
1
77
RoW
VRC01.23LS, PGT121.414.LS, PGDM1400LS
HIV Vaccine Trials Network, National Institute of Allergy and Infectious Diseases (NIAID)
HIV Infections
01/25
01/25
NCT04038060: The PrEP (Pre-exposure Prophylaxis) SMART Study

Completed
N/A
350
RoW
WhatsApp Group, 2-way SMS, Drug level feedback, Monthly counseling sessions
University of Washington, Wits Reproductive Health and HIV Institute, National Institute of Mental Health (NIMH)
HIV/AIDS
10/21
01/22
INSIGHT, NCT05746065: A Cohort for Evaluation of Open-label PrEP Use and PreP Preferences Among African Women

Completed
N/A
3087
RoW
PrEP, Truvada
University of Washington, Bill and Melinda Gates Foundation
HIV Infections
08/23
08/23
NCT05664490: Friendship Bench Mental Health Intervention for Adolescent Girls and Young Women in South African PrEP Delivery Settings

Recruiting
N/A
110
RoW
Youth Friendship Bench SA
University of California, San Francisco, National Institute of Mental Health (NIMH), University of Witwatersrand, South Africa
Depression, Pre-Exposure Prophylaxis
02/25
02/25
Delaney-Moretlwe, Sinead
No trials found

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