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7 Active 6 Inactive 13 All	Not yet recruiting Recruiting Enrolling by invitation Active, not recruiting Available No longer recruiting	Industry lead sponsor Industry collaborator Coop Other	US Canada Japan Europe RoW	N/A 1 2 3 4	Highlight changes:- Show only changed items Enrollment:

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Trial + Data / Events	Status	Ph	N	Region	Interventions	Sponsor	Conditions	Primary compl	Study compl
Bagshaw, Sean M
PLEXSIS, NCT05093075: Therapeutic Plasma Exchange in Septic Shock: a Pilot Study	Recruiting	2	80	NA	Therapeutic Plasma Exchange	University of Manitoba, Canadian Institutes of Health Research (CIHR), Health Sciences Centre Foundation, Manitoba, McMaster University, University of Toronto	Septic Shock	03/26	12/26
NCT04744298: Identification and Treatment of Hypoxemic Respiratory Failure and ARDS With Protection, Paralysis, and Proning Pathway	Active, not recruiting	N/A	19916	Canada	TheraPPP	University of Calgary, Alberta Health services	Acute Respiratory Distress Syndrome, Hypoxemic Respiratory Failure, ARDS, Human	03/24	10/25
ULTIMATE, NCT04832789: Ultra-Low Tidal Volume Mechanical Ventilation in ARDS Through ECMO	Not yet recruiting	N/A	72	Canada, US	Venovenous ECMO	University of Toronto, University Health Network, Toronto	ARDS	06/23	12/23
BALANCE, NCT03005145: Bacteremia Antibiotic Length Actually Needed for Clinical Effectiveness	Completed	N/A	3622	Europe, Canada, US, RoW	7 days of adequate antibiotic treatment, 14 days of adequate antibiotic treatment.	Sunnybrook Health Sciences Centre	Bacteremia, Intensive Care, Critically Ill, Sepsis, Mortality, Antimicrobial	05/23	08/23
HONOUR, NCT05078034: HNFO With or Without Helmet NIV for Oxygenation Support in Acute Respiratory Failure Pilot RCT	Recruiting	N/A	200	Canada	Helmet Non-Invasive Ventilation (HNIV), HNIV, High Flow Nasal Oxygen, HFNO	Sunnybrook Health Sciences Centre	Acute Hypoxemic Respiratory Failure	02/25	02/25
Probe-Fluid, NCT05473143: Proactive Prescription-based Fluid Management vs Usual Care in Critically Ill Patients on Kidney Replacement Therapy	Recruiting	N/A	150	Canada	Protocol-based fluid management, Usual care	Centre hospitalier de l'Université de Montréal (CHUM)	Acute Kidney Injury, Kidney Replacement, Critical Illness	09/24	01/25
WISDOM, NCT06446739: LoW Dose-Intensity vs. Standard Dose-Intensity COntinuous Renal ReplaceMent Therapy in Critically Ill Patients	Recruiting	N/A	100	Canada	Continuous Renal Replacement Therapy (CRRT)	University of Alberta	Acute Kidney Injury, Dialysis; Complications	04/25	07/25