| Clemons, Mark J |
REaCT-ZOL, NCT03664687: Comparing a Single-Dose vs. Twice Yearly Zoledronate in Patients With Early Stage Breast Cancer |
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| Active, not recruiting | 4 | 211 | Canada | Zoledronate, Zoledronic acid | Ottawa Hospital Research Institute | Early-stage Breast Cancer | 04/20 | 12/24 | | |
NCT05365230: A Randomized Trial Evaluating Personalized vs Guideline-based Well Follow-up Strategies for Patients With Early-stage Breast Cancer |
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| Active, not recruiting | 4 | 264 | Canada | On-demand personalized follow-up care, Guideline-based follow-up care (standard of care) | Ottawa Hospital Research Institute | Breast Cancer | 07/26 | 07/26 | | |
| Knoll, Greg A |
NCT03206801: Urine CXCL10 Monitoring Trial in Kidney Transplant |
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| Active, not recruiting | 2/3 | 420 | Canada, RoW | Kidney transplant biopsy, Protocol biopsy | University of Manitoba, Canadian Institutes of Health Research (CIHR), Canadian National Transplant Research Program | Kidney Transplant; Complications, Rejection of Renal Transplant | 06/24 | 09/25 | | |
CARSK, NCT03674307: Screening for Asymptomatic Coronary Artery Disease in Kidney Transplant Candidates |
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| Recruiting | N/A | 3306 | Europe, Canada, US | No screening, Regular Screening | University of British Columbia, University of Sydney | Cardiovascular Diseases, End Stage Renal Disease, Kidney Transplantation, Dialysis Related Complication | 12/25 | 12/25 | | |
| Freedman, Mark S |
| Active, not recruiting | 2 | 450 | Europe, Canada, US, RoW | IMU-838, Vidofludimus calcium, Placebo matching IMU-838, Placebo Arm | Immunic AG | Multiple Sclerosis | 01/25 | 01/25 | | |
PAT-MS, NCT04267185: A Dyadic Approach for Promoting Physical Activity Among People with MS and Their Support Partners |
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| Completed | N/A | 22 | Canada | Physical Activity Together for PwMS and their CGs (PAT-MS) | University of Ottawa, The Ottawa Hospital, Consortium of Multiple Sclerosis Centers, Queen's University | Multiple Sclerosis | 06/22 | 10/22 | | |
| Recruiting | N/A | 314 | Europe, Canada, US | MSCopilot® Detect mobile application | Ad scientiam | Multiple Sclerosis | 12/26 | 12/26 | | |
| McIsaac, Daniel I |
TRACTION, NCT04803747: A Trial of a Hospital Policy of Tranexamic Acid Use to Reduce Transfusion in Major Non-cardiac Surgery |
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| Active, not recruiting | 4 | 8440 | Canada | Tranexamic acid (TXA), Placebo (0.9 % Saline) | University of Manitoba, Canadian Institutes of Health Research (CIHR), Health Sciences Centre Foundation, Manitoba, The Ottawa Hospital | Major Non-cardiac Surgeries | 03/24 | 10/24 | | |
PLAN, NCT04874038: Prevention of Persistent Pain With LidocAine iNfusions in Breast Cancer Surgery |
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| Recruiting | 3 | 1602 | Canada, RoW | Lidocaine 20mg/ml, Lidocaine 2%, Placebo, 0.9% sodium chloride solution | University Health Network, Toronto, Canadian Institutes of Health Research (CIHR) | Post-mastectomy Pain Syndrome, Breast Cancer, Pain, Postoperative, Pain, Chronic | 06/25 | 06/26 | | |
| Active, not recruiting | N/A | 413 | Canada | Prehabilitation | Ottawa Hospital Research Institute | Surgery-Complications, Cancer, Frailty, Disability Physical | 05/29 | 05/30 | | |
NCT04221295: The PREPARE Trial: Exercise Before Surgery to Improve Recovery in Older People With Frailty |
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| Active, not recruiting | N/A | 850 | Canada | Exercise Group | Ottawa Hospital Research Institute | Frailty, Surgery--Complications, Disability Physical | 06/24 | 05/25 | | |
| Recruiting | N/A | 902 | Canada | Prehabilitation | Ottawa Hospital Research Institute, Canadian Institutes of Health Research (CIHR) | Surgery-Complications, Disability Physical | 01/27 | 12/31 | | |
| Recruiting | N/A | 270 | Canada | Protective "open-lung" extubation, Conventional extubation | Centre hospitalier de l'Université de Montréal (CHUM), CHU de Quebec-Universite Laval, The Ottawa Hospital, University Health Network, Toronto, Canadian Institutes of Health Research (CIHR) | Intra-abdominal Surgery, Anesthesia, Lung Injury, Ventilator-Induced Lung Injury, Atelectasis | 12/25 | 04/26 | | |
| Active, not recruiting | N/A | 144 | Canada | Prehabilitation intervention | Ottawa Hospital Research Institute, Canadian Institutes of Health Research (CIHR) | Surgery-Complications, Disability Physical | 01/25 | 09/25 | | |
| Not yet recruiting | N/A | 190 | Canada | | Ottawa Hospital Research Institute | Preoperative Care, Patient Education, Anesthesia, Artificial Intelligence | 05/25 | 06/25 | | |
| Recruiting | N/A | 90 | Canada | neuraxial anesthesia | Ottawa Hospital Research Institute, Canadian Institutes of Health Research (CIHR), The Ottawa Hospital Academic Medical Association, University of Ottawa | Vascular Diseases, Peripheral Artery Disease, Surgery | 12/25 | 01/27 | | |
| Carrier, Marc |
SAFE-SSPE, NCT04263038: Clinical Surveillance vs. Anticoagulation for Low-risk Patients With Isolated Subsegmental Pulmonary Embolism |
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| Recruiting | 4 | 276 | Europe, Canada | Rivaroxaban, Placebo | Drahomir Aujesky, University of Bern, Schweizerischer Nationalfonds, Leiden University Medical Center, The Ottawa Hospital, Bayer | Pulmonary Embolism, Embolism, Embolism and Thrombosis, Lung Diseases, Cardiovascular Diseases, Respiratory Tract Diseases, Venous Thromboembolism, Anticoagulant-induced Bleeding, Bleeding | 05/26 | 05/26 | | |
NCT05255003: STrategies for Anticoagulation in Patients With thRombocytopenia and Cancer-associated Thrombosis |
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| Recruiting | 4 | 50 | Canada | Enoxaparin, Lovenox, Dalteparin, Fragmin, Tinzaparin, Innohep | Ottawa Hospital Research Institute | Cancer-associated Thrombosis, Thrombocytopenia | 10/24 | 03/25 | | |
CONQUER-DVT, NCT06440694: Colchicine to Quench the Inflammatory Response After Deep Vein Thrombosis (The Conquer-DVT Pilot Trial) |
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| Not yet recruiting | 3 | 150 | Canada | Colchicine 0.5 mg po, Myinfla tablet 0.5 mg po daily, Placebo 0.5 mg po, Placebo 0.5 mg po daily | Ottawa Hospital Research Institute | Venous Thromboembolism | 12/27 | 12/27 | | |
| Completed | 3 | 1767 | Europe, Canada | Apixaban 5 MG, Apixaban 2.5 MG | Assistance Publique - Hôpitaux de Paris, Bristol-Myers Squibb | Cancer-associated Thrombosis | 09/24 | 10/24 | | |
| Recruiting | 3 | 1828 | Canada | Rivaroxaban 10 MG, Placebo | Ottawa Hospital Research Institute | Venous Thromboembolism, Cancer | 12/26 | 12/27 | | |
| Recruiting | 3 | 4000 | Canada, US, RoW | Heparin | University of Manitoba, Canadian Institutes of Health Research (CIHR), Research Manitoba, Ozmosis Research Inc., Canadian Venous Thromboembolism Clinical Trials and Outcomes Research (CanVECTOR) Network, Canadian Critical Care Trials Group, AVANTI | Community-acquired Pneumonia | 03/28 | 03/29 | | |
PrOVE iT, NCT06662253: Anti-Xa Guided Dosing of Low Molecular Weight Heparin for Prevention of Venous Thromboembolism Following Traumatic Injury: a Multicentre Pilot Randomized Trial |
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| Not yet recruiting | 2/3 | 150 | NA | Anti-Xa Guided Dosing of Low Molecular Weight Heparin, Standard of Care Dosing | Alexandre Tran | Venous Thromboembolism (VTE), Trauma Related Injuries | 06/26 | 09/26 | | |
| Recruiting | 2/3 | 120 | Canada | Rivaroxaban 10 MG, Xarelto, Placebo control | Ottawa Hospital Research Institute, Canadian Institutes of Health Research (CIHR), Canadian Venous Thromboembolism Clinical Trials and Outcomes Research (CanVECTOR) Network, Kidney Cancer Research Network of Canada | Venous Thromboembolism, Urologic Cancer | 10/26 | 10/26 | | |
WAVe, NCT03297359: Study - Weight Adjusted Dalteparin for Patients Over 90 kg With Acute Cancer Associated Venous Thromboembolism |
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| Terminated | 2 | 92 | Canada | Dalteparin | Ottawa Hospital Research Institute, Canadian Venous Thromboembolism Clinical Trials and Outcomes Research (CanVECTOR) Network | Cancer, Venous Thromboembolism, Obesity | 11/23 | 11/23 | | |
| Recruiting | N/A | 1276 | Europe, Canada | Limited cancer screening, Limited cancer screening + FDG PET/CT | University Hospital, Brest, Ministry of Health, France, Canadian Institutes of Health Research (CIHR), Ottawa Hospital Research Institute | Embolism and Thrombosis | 09/26 | 09/30 | | |
| Dowlatshahi, Dariush |
| Completed | 3 | 850 | Europe, Canada, US, RoW | Placebo, Nerinetide, NA-1 | NoNO Inc., University of Calgary | Stroke, Acute | 08/23 | 08/23 | | |
TEMPO-2, NCT02398656: A Randomized Controlled Trial of TNK-tPA Versus Standard of Care for Minor Ischemic Stroke With Proven Occlusion |
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| Completed | 3 | 886 | Europe, Canada, RoW | Tenecteplase, TNK-tPA, Antiplatelet treatment, ASA, Clopidogrel | University of Calgary | Stroke, Acute | 01/24 | 04/24 | | |
| Completed | 2 | 100 | Canada | Colchicine Pill, Placebo | Population Health Research Institute | Intracranial Hemorrhages | 12/24 | 12/24 | | |
| Hladkowicz, Emily |
TRACTION, NCT04803747: A Trial of a Hospital Policy of Tranexamic Acid Use to Reduce Transfusion in Major Non-cardiac Surgery |
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| Active, not recruiting | 4 | 8440 | Canada | Tranexamic acid (TXA), Placebo (0.9 % Saline) | University of Manitoba, Canadian Institutes of Health Research (CIHR), Health Sciences Centre Foundation, Manitoba, The Ottawa Hospital | Major Non-cardiac Surgeries | 03/24 | 10/24 | | |
NCT04221295: The PREPARE Trial: Exercise Before Surgery to Improve Recovery in Older People With Frailty |
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| Active, not recruiting | N/A | 850 | Canada | Exercise Group | Ottawa Hospital Research Institute | Frailty, Surgery--Complications, Disability Physical | 06/24 | 05/25 | | |
| Recruiting | N/A | 902 | Canada | Prehabilitation | Ottawa Hospital Research Institute, Canadian Institutes of Health Research (CIHR) | Surgery-Complications, Disability Physical | 01/27 | 12/31 | | |
| Recruiting | N/A | 90 | Canada | neuraxial anesthesia | Ottawa Hospital Research Institute, Canadian Institutes of Health Research (CIHR), The Ottawa Hospital Academic Medical Association, University of Ottawa | Vascular Diseases, Peripheral Artery Disease, Surgery | 12/25 | 01/27 | | |
| Dowlatshahi, Dar |
| Active, not recruiting | 4 | 948 | Europe, Canada, US, RoW | Edoxaban, Lixiana, Savaysa, Non-anticoagulant medical therapy | Population Health Research Institute | Intracranial Hemorrhages, Atrial Fibrillation | 04/26 | 10/26 | | |
| Recruiting | 3 | 860 | Europe, Canada, Japan, US | Recombinant Activated Factor VII (rFVIIa), NovoSeven, NiaStase, Placebo | Joseph Broderick, MD, Novo Nordisk A/S, National Institute of Neurological Disorders and Stroke (NINDS) | Intracerebral Hemorrhage | 01/28 | 01/28 | | |
| Recruiting | 2/3 | 200 | Europe, Canada, US | Immediate mechanical thrombectomy(iMT) using EmboTrap Revascularization Device, EmboTrap III, Initial medical management (iMM) | Emory University, University of Calgary, University of Cincinnati, Heidelberg University, Children's Hospital Medical Center, Cincinnati | Cerebral Ischemia | 12/24 | 12/24 | | |
| Terminated | 2 | 142 | Canada | labetalol/hydralazine/enalapril | University of Alberta | Intracerebral Hemorrhage | 11/21 | 12/21 | | |
| Recruiting | N/A | 45 | Canada | FDG PET/CT, Usual Care | Ottawa Hospital Research Institute, Brain Canada, Heart and Stroke Foundation of Canada, Canadian Stroke Consortium (CSC) | Occult Cancer | 01/25 | 01/26 | | |
| Active, not recruiting | N/A | 530 | Europe, Canada, US | endovascular thrombectomy (EVT), solitaire X, Standarad medical care | Dr. Michael D Hill, University of Calgary | Acute Ischemic Stroke | 12/25 | 06/26 | | |
| Kendzerska, Tetyana |
NCT03383354: The Link Between Clinical and Physiological Sleep Data and Health-related Outcomes |
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| Active, not recruiting | N/A | 5000 | Canada | Sleep-related disturbances (exposure) | Sunnybrook Health Sciences Centre, Institute for Clinical Evaluative Sciences, Ottawa Hospital Research Institute | Sleep Apnea Syndromes, Cardiovascular Diseases, Sleep Initiation and Maintenance Disorders, Nocturnal Myoclonus Syndrome, Hospitalizations, Mortality, Cancer | 06/25 | 06/25 | | |
NCT03834792: Adverse Long-term Consequences of Sleep Disordered Breathing: The Ottawa Hospital (TOH) Sleep Database |
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| Active, not recruiting | N/A | 5155 | Canada | No intervention but exposure | Ottawa Hospital Research Institute, University of Ottawa, University of Toronto, University of Western Ontario, Canada | Polysomnography, Sleep Apnea Syndromes, Risk Factors, Prognosis, Restless Legs Syndrome, Periodic Limb Movement Sleep Disorder, Sleep Arousal Disorders, Opioid Use | 12/25 | 12/28 | | |
| Gill, Jagbir |
CARSK, NCT03674307: Screening for Asymptomatic Coronary Artery Disease in Kidney Transplant Candidates |
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| Recruiting | N/A | 3306 | Europe, Canada, US | No screening, Regular Screening | University of British Columbia, University of Sydney | Cardiovascular Diseases, End Stage Renal Disease, Kidney Transplantation, Dialysis Related Complication | 12/25 | 12/25 | | |
| Thomas, Erin |
COBRRA, NCT03266783: Comparison of Bleeding Risk Between Rivaroxaban and Apixaban for the Treatment of Acute Venous Thromboembolism |
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| Recruiting | 4 | 2760 | Europe, Canada, RoW | Apixaban, Eliquis, Rivaroxaban, Xarelto | Ottawa Hospital Research Institute, Canadian Venous Thromboembolism Clinical Trials and Outcomes Research (CanVECTOR) Network, Canadian Institutes of Health Research (CIHR) | Venous Thromboembolism | 12/24 | 12/24 | | |
COBRRA AF, NCT04642430: COmparison of Bleeding Risk Between Rivaroxaban and Apixaban in Patients With Atrial Fibrillation |
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| Recruiting | 4 | 3018 | Canada | Apixaban, Eliquis, Rivaroxaban, Xarelto | Ottawa Hospital Research Institute, Canadian Venous Thromboembolism Clinical Trials and Outcomes Research (CanVECTOR) Network, Canadian Institutes of Health Research (CIHR) | Atrial Fibrillation | 12/26 | 12/26 | | |
CARSK, NCT03674307: Screening for Asymptomatic Coronary Artery Disease in Kidney Transplant Candidates |
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| Recruiting | N/A | 3306 | Europe, Canada, US | No screening, Regular Screening | University of British Columbia, University of Sydney | Cardiovascular Diseases, End Stage Renal Disease, Kidney Transplantation, Dialysis Related Complication | 12/25 | 12/25 | | |
| McGee, Sharon |
REaCT-HER TIME, NCT04928261: Evaluating 6-months of HER2-targeted Therapy in Patients With HER2 Positive Early-stage Breast Cancer That Achieve a Pathological Complete Response to Neoadjuvant Systemic Therapy |
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| Recruiting | 4 | 50 | Canada | Trastuzumab, Herceptin | Ottawa Hospital Research Institute | Breast Cancer | 09/25 | 09/25 | | |
| Sampaio, Roney O |
| Recruiting | 3 | 2625 | Europe, Canada, RoW | Warfarin, Coumadin | Population Health Research Institute, Hamilton Health Sciences Corporation | Bleeding Post-mechanical Valve Replacement, Thromboembolism Post-mechanical Valve Replacement | 03/25 | 12/26 | | |
| Fisette-Paulhus, Isabelle |
| Terminated | 3 | 260 | Europe, Canada, US | Losmapimod, Placebo oral tablet | Fulcrum Therapeutics | Facioscapulohumeral Muscular Dystrophy (FSHD) | 11/24 | 11/24 | | |
| Recruiting | N/A | 450 | Europe, Canada, US | | University of Kansas Medical Center, FSHD Society, Inc., Friends Research Institute, Inc., University of Rochester, University of Nevada, Reno, FSHD Canada, Avidity Biosciences, Inc., AMRA Medical, Seattle Children's Hospital, Dyne Therapeutics, Hoffmann-La Roche | FSHD | 12/26 | 01/27 | | |
