| Defer, Gilles |
| Active, not recruiting | 3 | 134 | Europe | Apomorphine, Apokinon, Best Medical Treatment | Rennes University Hospital | Parkinson's Disease | 12/23 | 01/25 | | |
TRIO, NCT05758831: RItuximab Versus Ocrelizumab in Relapsing-remitting Multiple Sclerosis. |
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| Recruiting | 3 | 386 | Europe | Perfusion of treatment Rituximab, Perfusion of treatment Ocrelizumab | Rennes University Hospital | Multiple Sclerosis, Relapsing-remitting Multiple Sclerosis | 03/30 | 05/30 | | |
SEPIA, NCT03471338: Neuropsychological Management of Multiple Sclerosis: Benefits of a Computerised Semi-autonomous At-home Cognitive Rehabilitation Programme |
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| Active, not recruiting | N/A | 40 | Europe | Cognitive rehabilitation, Standard Psychological care | University Hospital, Caen | Relapsing Remitting Multiple Sclerosis, Secondary Progressive Multiple Sclerosis | 12/24 | 12/24 | | |
NeurofilMS, NCT03981003: Serum Neurofilament-light Chain and GFAP Levels in Patients From the OFSEP Cohort at Different Landmarks of Multiple Sclerosis |
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| Recruiting | N/A | 1150 | Europe, RoW | Blood sample | Centre Hospitalier Universitaire de Nīmes, Hospices Civils de Lyon | Multiple Sclerosis | 06/28 | 06/28 | | |
| Recruiting | N/A | 1000 | Europe, RoW | No intervention | Hospices Civils de Lyon | Sclerosis, Multiple, Neuromyelitis Optica Spectrum Disorder, Myelin Oligodendrocyte Glycoprotein (MOG)-Antibody Related Disorders, Pregnancy Abnormal | 08/36 | 08/36 | | |
NCT05516303: Pharmacogenetics of Liver Toxicity in Patients With Multiple Sclerosis Treated With Fingolimod |
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| Recruiting | N/A | 65 | Europe | Genetic polymorphism, Measurement of fingolimod and fingolimod-phosphate concentrations | University Hospital, Caen | Multiple Sclerosis | 10/22 | 10/22 | | |
| MINCKES, Odile |
CAALL-F01, NCT02716233: A French Protocol for the Treatment of Acute Lymphoblastic Leukemia (ALL) in Children and Adolescents |
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| Recruiting | 3 | 1578 | Europe | pegaspargase 1250 IU/m2 x 2, ONCASPAR 1250 IU/m2 x 2, pegaspargase 2500 IU/m2 x 1, ONCASPAR 2500 IU/m2 x 1 | Assistance Publique - Hôpitaux de Paris, Shire | Acute Lymphoblastic Leukemia | 04/26 | 04/26 | | |
| Active, not recruiting | 2 | 133 | Europe | VP16, carboplatin, etoposide, vepesid, chemotherapy, Melphalan, Alkeran, chemotherapy, VP16, carboplatin, vincristin, etoposide, vepesid, leurocristine, Oncovin, chemotherapy, Carboplatin + laser day 1 (chemothermotherapy), Carbo-laser, platinum-based chemotherapy, Laser (local treatment), Laser diode, cryoapplication (local treatment), I125 radioactive plaques (local treatment), intravitreal Melphalan (local treatment) | Institut Curie, Fondation Rothschild Paris | Retinoblastoma, Children, Retinal Neoplasm | 01/23 | 09/35 | | |
| RENARD, Eric |
ISLET CHIP, NCT03067324: Quality Control of Pancreatic Islet Intended to Islet Graft Cells Intended to Stabilot Islet Graft Protocol |
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| Recruiting | N/A | 40 | Europe | | University Hospital, Grenoble, University Hospital, Bordeaux | Pancreatic Islet Quality Control | 12/20 | 07/21 | | |
| Active, not recruiting | N/A | 122 | Europe | Closed-loop insulin infusion driven by continuous glucose monitoring through an algorithm, in free-life conditions, Artificial pancreas | University Hospital, Montpellier | Type 1 Diabetes Mellitus in Prepubertal Children | 09/22 | 05/23 | | |
| Recruiting | N/A | 72 | Europe | Closed-loop insulin infusion driven by continuous glucose monitoring through an algorithm, in free-life conditions, Artificial Pancreas, Continuous Subcutaneous Insulin Infusion and Continuous Glucose Monitoring, Sensor Augmented Pump, CSII and CGM | University Hospital, Montpellier, Tandem Diabetes Care, Inc., DexCom, Inc., National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), University of Virginia | Type 1 Diabetes Mellitus With Hypoglycemia | 11/22 | 02/23 | | |
| Completed | N/A | 304 | Europe | assessment of biomarkers of insulin resistance | University Hospital, Montpellier, Centre National de la Recherche Scientifique, France, Sys2Diag, Mixt laboratory CNRS/Alcediag, Montpellier | Insulin Resistance | 09/23 | 07/24 | | |
| Active, not recruiting | N/A | 200 | Europe, US | Omnipod 5 System | Insulet Corporation | Type 1 Diabetes | 09/23 | 01/25 | | |
NCT02808572: New Biomarkers of Bone Mineral Metabolism as Cardiovascular Risk Factors in Chronic Kidney Disease Patients |
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| Recruiting | N/A | 250 | Europe | Plasma osteoprotegerin level, Plasma fibroblast growth factor 23 level, Vascular calcification score | University Hospital, Montpellier | Chronic Kidney Disease | 03/24 | 06/31 | | |
NCT05597605: The SHINE Study: Safety of Implant and Preliminary Performance of the SHINE SYSTEM in Diabetic Subjects |
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| Completed | N/A | 6 | Europe | The SHINE SYSTEM | Indigo Diabetes NV | Diabetes Mellitus, Diabetes Mellitus, Type 1, Diabetes Mellitus, Type 2, Ketoacidosis, Diabetic, Hyperglycaemia (Diabetic), Hypoglycemia | 12/23 | 01/24 | | |
| Active, not recruiting | N/A | 200 | Europe | Omnipod 5 System | Insulet Corporation | Diabetes Mellitus, Type 1 | 08/24 | 08/25 | | |
TELXCODIA, NCT04769765: Feasability of a Care Pathway Integrating Collaborative Tele-expertise to Prevent Recurring Hospitalisations for Diabetic Patients |
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| Recruiting | N/A | 200 | Europe | Definition of the Individualized Care Pathway | Centre Hospitalier Universitaire de Nīmes, University Hospital, Montpellier, Hospital Center, Alès, CH Bagnols sur Cèze, CH Béziers, HOPITAL ST CLAIR HBT SETE, Centre Hospitalier Saint Jean Perpignan, CH Narbonne HÔTEL DIEU | Diabetes Mellitus | 05/24 | 05/24 | | |
APATDIAGNOSIS, NCT06283797: Efficacy of Automated Insulin Therapy Early Initiated After Diagnosis on Blood Glucose Control in Children and Adolescents with Type 1 Diabetes |
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| Recruiting | N/A | 112 | Europe | OmniPod 5, Dexcom G6, PAID questionnaires | University Hospital, Montpellier, Hopital Universitaire Robert-Debre, University Hospital, Tours, University Hospital, Angers, University of Virginia | Diabetes | 06/26 | 06/27 | | |
NCT06738849: EkiYou-Study-2 : a National Multicentric Trial of the EkiYou Application for Insulin Bolus Calculation |
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| Recruiting | N/A | 154 | Europe | EkiYou V2 | DiappyMed, Sanoia | Diabetes Type 1, Diabetes Type 2 on Insulin, Pancreatogenous Diabetes | 05/25 | 11/25 | | |
| Dollfus, Sonia |
PSYCARE, NCT05796401: Efficiency of a Composite Personalised Care on Functional Outcome in Early Psychosis |
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| Not yet recruiting | 3 | 500 | Europe | Cognitive training, Personalized neuroprotective strategies : Vitamin B12, folinic acid, Omega 3, NAC, Treatment as usual (TAU) | Centre Hospitalier St Anne | Psychosis | 07/26 | 06/28 | | |
| Recruiting | N/A | 61 | Europe | Magstim® Active TBS, Magstim® Sham TBS | University Hospital, Caen, University Hospital, Rouen, Centre Hospitalier Universitaire Dijon, Poitiers University Hospital | Social Cognition in Patients With Schizophrenia | 03/23 | 03/23 | | |
| Recruiting | N/A | 64 | Europe | Electroconvulsive therapy | Centre Hospitalier du Rouvray, University Hospital, Rouen, University Hospital, Bordeaux, Nantes University Hospital, University Hospital, Toulouse, University Hospital, Caen, Centre Hospitalier Henri Laborit, Centre Hospitalier St Anne, Centre Hospitalier de Cadillac, Hôpital Louis Mourier, University Hospital, Montpellier, University Hospital, Clermont-Ferrand, Centre hospitalier de Ville-Evrard, France | Schizophrenia, Electroconvulsive Therapy | 10/23 | 10/23 | | |
MAINSTIM, NCT05550155: Efficacy of Maintenance Repetitive Transcranial Magnetic Stimulation (rTMS) in Auditory Verbal Hallucinations |
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| Not yet recruiting | N/A | 120 | Europe | Repetitive Transcranial Magnetic Stimulation (rTMS) Treatment, Sham Repetitive Transcranial Magnetic Stimulation (rTMS) | University Hospital, Caen | Schizophrenia; Psychosis | 11/25 | 04/26 | | |
| ROUPIE, Eric |
| Recruiting | N/A | 500 | Europe | Guidance of the External Chest Compression, CPRmeter's feedback, Rhythm of a relay 4 minutes | University Hospital, Caen | Cardiac Arrest, Cardiopulmonary Resuscitation | 11/24 | 01/25 | | |
| Reznik, Yves |
| Completed | N/A | 51 | Europe | Patient group, Remission control group, Bilateral surrenalectomy control group | University Hospital, Bordeaux | Cushing Disease | 06/22 | 06/22 | | |
IMPLIQUE, NCT04939766: Impact of the Use of a Closed-loop Insulin Therapy on the Burden of the Diabetes and the Quality of Life |
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| Not yet recruiting | N/A | 250 | NA | Activation of a closed loop device in an insulin pump device with GCM | VitalAire | Quality of Life, Burden, Dependency | 09/22 | 12/22 | | |
DAPS, NCT05640128: Determination of Threshold Values of Aldosterone in HPLC-MS/MS, of Renin and of the Aldosterone / Renin Ratio for the Diagnosis of Primary Hyperaldosteronism |
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| Recruiting | N/A | 300 | Europe | Aldosterone in HPLC-MS/MS | University Hospital, Caen | Hyperaldosteronism; Primary | 01/23 | 01/24 | | |
ACTIDIANE, NCT03184662: Efficacy of a High-intensity Physical Activity Program on Renal Function in High Risk Patients With Type 2 Diabetes |
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| Recruiting | N/A | 300 | Europe | HIPA, Counseling PA | Poitiers University Hospital, University Hospital, Bordeaux, University Hospital, Clermont-Ferrand, Centre Hospitalier Universitaire Dijon, Centre Hospitalier Universitaire de Besancon, Hopital Lariboisière, Bichat Hospital, Centre Hospitalier Sud Francilien, University Hospital, Lille, Centre Hospitalier Universitaire de Nice, University Hospital, Caen, University Hospital, Toulouse, University Hospital, Tours, Nantes University Hospital, Groupe Hospitalier Pitie-Salpetriere, Hospices Civils de Lyon, University Hospital, Montpellier, University Hospital, Strasbourg, Central Hospital, Nancy, France, HOSPITAL, CHARTRES, University of Liege | Type2 Diabetes, Diabetic Kidney Disease | 09/23 | 12/23 | | |
| Recruiting | N/A | 348 | Europe | DBLG1 System | Diabeloop | Type1diabetes | 07/25 | 01/26 | | |
| Recruiting | N/A | 1000 | Europe, RoW | | University Hospital, Bordeaux, Fondation Francophone pour la Recherche sur le Diabete | Diabetic Foot Ulcer | 11/29 | 11/29 | | |
| Not yet recruiting | N/A | 400 | Europe | | University Hospital, Lille | Gender Dysphoria | 04/30 | 04/30 | | |
| Recruiting | N/A | 3000 | Europe | No intervention | European Georges Pompidou Hospital, Oscar - Filière Santé Maladies Rares | Hypoparathyroidism | 09/30 | 09/31 | | |
| Sayette, Vincent de La |
NCT02810197: Resilience and Modification of Brain Control Network Following November 13 |
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| Recruiting | N/A | 180 | Europe | Psychopathological assessment, Neuropsychological assessment, Functional magnetic resonance imaging (fMRI) | Institut National de la Santé Et de la Recherche Médicale, France | Post-Traumatic Stress Disorder | 04/22 | 04/23 | | |
| Recruiting | N/A | 75 | Europe | Functional Magnetic Resonance Imaging at rest and in activation with attentional task, Spatial memory task, Cognitive battery, quality of life questionnaires | Centre Francois Baclesse, UMR_S 1077 Inserm-EPHE-Normandie Université | Breast Cancer, Sleep, Quality of Life | 03/27 | 09/27 | | |
| EUSTACHE, francis |
Program14-7, NCT03356028: Pedopsychiatric and Multidisciplinary Research Devoted to Children Exposed to the Attack in Nice on July 14, 2016 |
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| Active, not recruiting | N/A | 728 | Europe | Child and adolescent psychiatry and Epidemiology, salivary biological collection, qualitative analysis of the discourse, Parenthood, Cognitive alterations, Impact on schooling, Sleep disorders and associated somatizations | Fondation Lenval | Psychiatric Disorder, Trauma, Psychological | 12/44 | 12/44 | | |
| FELLAHI, Jean-Luc |
| Active, not recruiting | N/A | 1113 | Europe | | Centre Hospitalier Universitaire, Amiens | Vasoplegic Syndrome of Cardiac Surgery | 12/23 | 12/24 | | |
| Recruiting | N/A | 570 | Europe | Autotransfusion | University Hospital, Bordeaux | On-pump Cardiac Surgery, High Risk for Bleeding, Autotransfusion | 02/26 | 02/26 | | |
EPIC-ECMO, NCT06038162: Evaluation of Integrated Versus Parallel Connection for Renal Replacement Therapy in ECMO Patients |
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| Recruiting | N/A | 158 | Europe | Parallel connection, Integrated connection | Hospices Civils de Lyon | Venoarterial Extracorporeal Membrane Oxygenation, Renal Replacement Therapy, Acute Kidney Injury | 09/25 | 09/26 | | |
| OLLIVIER, Isabelle |
ProPILARifax, NCT03069131: Two Strategies of Primary Prophylaxis of Spontaneous Bacterial Peritonitis in Severe Cirrhotic Patients With Ascites |
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| Completed | 3 | 160 | Europe | Rifaximin, Placebo | Centre Hospitalier Universitaire de Besancon, Alfasigma S.p.A., LC2 PHARMA | Cirrhosis, Ascites, Peritonitis | 06/22 | 03/23 | | |
| Completed | N/A | 104 | Europe | Transjugular Portosytemic Shunt (TIPS), glue obliteration | Centre Hospitalier Universitaire de Besancon | Bleeding Gastric Varices, Cirrhosis | 03/23 | 02/24 | | |
NCT06032754: PortoSinusoidal Vascular Diseases and Systemic Sclerosis |
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| Completed | N/A | 180 | Europe | | University Hospital, Caen | PSVD With or Without SSc | 03/24 | 03/24 | | |
| Hanouz, Jean-Luc |
| Recruiting | N/A | 70 | Europe | alveolar recruitment manoeuver | University Hospital, Caen | Alveolar Recruitment Manoeuver, Anesthesia | 10/21 | 04/22 | | |
soliso-2, NCT05080309: Effect of Oral Carbohydrate Intake > 44kCal Per Hour During Labour on the Rate of Instrumental Vaginal Delivery |
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| Not yet recruiting | N/A | 600 | NA | carbohydrate oral intake, free water only | University Hospital, Caen | Delivery Complication, Labor Long, Pregnancy Related | 09/22 | 09/22 | | |
| Recruiting | N/A | 220 | Europe | preoperative stroke volume optimization, Post induction stroke volume optimization | University Hospital, Caen | Anesthesia, Anesthesia Complication, Anesthesia Induction, Arterial Hypotension | 12/26 | 12/27 | | |
| Not yet recruiting | N/A | 250 | NA | standardized dose, standardized dose of bupivacaine, adjusted dose, adjusted dose of bupivacaine | University Hospital, Caen | Regional Anesthesia Morbidity, Cesarean Section Complications, Local Anesthetic Complication | 12/24 | 12/24 | | |
| MACREZ, Richard |
RIVACAST, NCT06195540: RIVAroxaban Versus Low-molecular Weight Heparin in Patients with Lower Limb Trauma Requiring Brace or CASTing |
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| Recruiting | 3 | 1424 | Europe | Rivaroxaban 10 MG, Low Heparin Molecular Weight | University Hospital, Angers | Venous Thromboembolism, Deep Vein Thrombosis, Pulmonary Embolism, Lower Limb Trauma, Thromboprophylaxis, Immobilisation | 11/26 | 11/26 | | |
PRESTO-F, NCT04121013: PREhospital Routage of Acute STroke Patients With Suspected Large Vessel Occlusion: Mothership Versus Drip and Ship |
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| Recruiting | N/A | 800 | Europe | mothership | University Hospital, Caen | Stroke | 01/22 | 01/22 | | |
NCT04870684: Thromboelastometry and Ischemic Stroke (ThromboPredict) |
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| Not yet recruiting | N/A | 200 | Europe | thromboelastometry test | University Hospital, Caen | Cerebrovascular Stroke, Thrombolytic Therapy, Mechanical Thrombectomy | 04/24 | 05/24 | | |
| HALBOUT, Laurent |
| Recruiting | N/A | 500 | Europe | Guidance of the External Chest Compression, CPRmeter's feedback, Rhythm of a relay 4 minutes | University Hospital, Caen | Cardiac Arrest, Cardiopulmonary Resuscitation | 11/24 | 01/25 | | |
| ARROT, Xavier |
| Recruiting | N/A | 500 | Europe | Guidance of the External Chest Compression, CPRmeter's feedback, Rhythm of a relay 4 minutes | University Hospital, Caen | Cardiac Arrest, Cardiopulmonary Resuscitation | 11/24 | 01/25 | | |
| BULEON, Clement |
| Recruiting | N/A | 500 | Europe | Guidance of the External Chest Compression, CPRmeter's feedback, Rhythm of a relay 4 minutes | University Hospital, Caen | Cardiac Arrest, Cardiopulmonary Resuscitation | 11/24 | 01/25 | | |
| GABEREL, Thomas |
| Suspended | 3 | 440 | Europe | EVD + IVF with Alteplase, Intraventricular fibrinolysis with Alteplase | University Hospital, Caen | Subarachnoid Hemorrhage | 03/24 | 03/24 | | |
| Completed | N/A | 201 | Europe | Decompressive craniectomy (DC) and best medical treatment, Best medical treatment | Insel Gruppe AG, University Hospital Bern | Cerebral Hemorrhage | 10/23 | 05/24 | | |
| HODZIC, Amir |
| Recruiting | N/A | 32 | Europe | Cardiovascular and Baroreflex stimulation by Tilting, Tilt, Cardiovascular and Baroreflex stimulation by Lower Body Negative Pressure, LBNP | University Hospital, Caen, INSERM UMR-S 1075 COMETE, Caen, France, CNRS UMR 5220 INSERM U1294 CREATIS ,Université Lyon 1, INSA Lyon, France, Jozef Stefan Institute | Diabetes type1, Healthy | 11/24 | 01/25 | | |
| Brucato, Sylvie |
| Completed | 2 | 108 | Europe, Canada, US, RoW | rodatristat ethyl 300 mg tablet BID, rodatristat ethyl 600 mg BID, Placebo | Altavant Sciences GmbH | Pulmonary Arterial Hypertension | 06/23 | 08/23 | | |
| TOUZE, Emmanuel |
PRESTO-F, NCT04121013: PREhospital Routage of Acute STroke Patients With Suspected Large Vessel Occlusion: Mothership Versus Drip and Ship |
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| Recruiting | N/A | 800 | Europe | mothership | University Hospital, Caen | Stroke | 01/22 | 01/22 | | |
| Recruiting | N/A | 4000 | Europe | | Hopital Foch | Stroke, Acute | 12/22 | 12/22 | | |
| BULEON, Clément |
| Recruiting | N/A | 500 | Europe | Guidance of the External Chest Compression, CPRmeter's feedback, Rhythm of a relay 4 minutes | University Hospital, Caen | Cardiac Arrest, Cardiopulmonary Resuscitation | 11/24 | 01/25 | | |
| ALEXANDRE, Cénéric |
LaparoDAN, NCT04174807: Prospective Study of Antenatal Diagnostic Criteria for Digestive Complications of Gastroschisis |
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| Recruiting | N/A | 200 | Europe, RoW | | University Hospital, Angers | Gastroschisis, Intestinal Occlusion | 05/22 | 05/22 | | |
| Fauvet |
MISC-TRAIN, NCT06647849: Interest of Simulation Training on the Announcement of Early Pregnancy Loss on the Psychological Impact of the Patients |
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| Recruiting | N/A | 1000 | Europe | centers whose interns receive simulation training in the announcement of early spontaneous miscarriage between the 2 inclusion phases, centers with standard in-house management of spontaneous miscarriage/pregnancy arrested in the emergency department | University Hospital, Angers, Direction Générale de l'Offre de Soins | Early Pregnancy Loss, Spontaneous Miscarriage | 05/25 | 06/26 | | |
