| Galle, Peter R |
| Recruiting | 3 | 434 | Europe, Japan | Atezolizumab, Tecentriq, Bevacizumab, Avastin, TACE, transarterial chemoembolization | Institut für Klinische Krebsforschung IKF GmbH at Krankenhaus Nordwest, F. Hoffmann-La Roche Ltd | Hepatocellular Carcinoma | 07/27 | 07/27 | | |
| Recruiting | 3 | 496 | Europe, Japan, US, RoW | Regorafenib in combination with pembrolizumab, Stivarga® (regorafenib), Keytruda® (pembrolizumab), Loco-regional therapy, Convention transarterial chemoembolization (cTACE), Drug-eluting bead transarterial chemoembolization (DEB-TACE), Transarterial Chemoembolization (TACE), Transarterial radioembolization (TARE) | Translational Research in Oncology, Bayer | Carcinoma, Hepatocellular | 10/25 | 04/27 | | |
NCT05733598: Study of RP2 in Combination With Second-line Therapy in Patients With Locally Advanced Unresectable or Metastatic HCC |
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| Recruiting | 2 | 30 | US | RP2, Bevacizumab, Avastin, Atezolizumab, Tecentriq | Replimune Inc., Roche Pharma AG | Hepatocellular Carcinoma | 12/27 | 07/28 | | |
| Recruiting | N/A | 1000 | Europe | Physician's choice according to patient's needs. | iOMEDICO AG | Hepatocellular Carcinoma (HCC), Cholangiocarcinoma | 12/26 | 12/26 | | |
| Neumann, Helmut |
| Active, not recruiting | N/A | 600 | Europe | CAD with LCI for colorectal polyp detection | Johannes Gutenberg University Mainz | Focus of the Study is to Evaluate a New Developed Deep-learning Computer-aided Detection System in Combination With LCI for Colorectal Polyp Detection | 08/20 | 09/20 | | |
NCT04457934: Effectiveness of PLENVU in the General Screening Population and Patients With IBD |
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| Recruiting | N/A | 290 | Europe | Plenvu | Johannes Gutenberg University Mainz | IBD, Healthy | 01/21 | 08/21 | | |
| Recruiting | N/A | 404 | Europe | Plenvu | Johannes Gutenberg University Mainz | Quality Standards in Colonoscopy, Patient Education, Acceptance of Bowel-preparation | 01/21 | 06/21 | | |
NCT04734912: Evaluation of Transnasal Endoscopy During COVID-19 Pandemic |
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| Recruiting | N/A | 500 | Europe | gastroscopy in transnasal techique | Johannes Gutenberg University Mainz | Endoscopy | 06/21 | 12/21 | | |
| Completed | N/A | 830 | Europe, US | Computer Aided Detection (CADe) | NEC Corporation, Meditrial Europe Ltd., Meditrial USA Inc. | Colorectal Cancer, Adenoma Colon, Polyp of Colon | 09/24 | 09/24 | | |
Fuji AI, NCT04894708: Study on the Use of Artificial Intelligence (Fujifilm) for Polyp Detection in Colonoscopy |
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| Recruiting | N/A | 1572 | Europe | colonoscopy | Universitätsklinikum Hamburg-Eppendorf, FUJIFILM Deutschland, Branch office of FUJIFILM Europe GmbH | Screening Colonoscopy, Colonoscopic Control After Polypectomy, Suspected Colon Polyps | 05/24 | 09/24 | | |
| Schnorbus, Boris |
MICAT, NCT02180178: Mainz Intracoronary Database. The Coronary Slow-flow and Microvascular Diseases Registry |
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| Recruiting | N/A | 1000 | Europe | observational only- no intervention | Johannes Gutenberg University Mainz | Coronary Artery Disease, Microvascular Dysfunction | 09/28 | 09/28 | | |
| Gori, Tommaso |
| Completed | 4 | 200 | Europe | Quantitative flow ratio, Assessment of angiographic severity of the stenosis | Johannes Gutenberg University Mainz | Coronary Artery Disease | 04/23 | 04/24 | | |
| Completed | 4 | 1105 | Europe | Iron, Saline, salin | Universitätsklinikum Hamburg-Eppendorf, Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK), Charite University, Berlin, Germany | Systolic Heart Failure, Iron Deficiency | 05/24 | 05/24 | | |
EXAMINE-CAD, NCT05294887: Randomized Trial to Examine a Differential Therapeutic Response in Symptomatic Patients With Non-obstructive Coronary Artery Disease |
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| Recruiting | 4 | 132 | Europe | Bisoprolol, beta blocker, Diltiazem, Placebo | Charite University, Berlin, Germany, Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK) | Coronary Microvascular Dysfunction, Microvascular Angina, Vasospasm, Coronary, Vasospastic Angina, Prinzmetal Angina, Coronary Artery Disease | 06/24 | 06/24 | | |
EPIDAURUS, NCT04981041: Escalated Single Platelet Inhibition for One Month Plus NOAC in Patients With Atrial Fibrillation and ACS Undergoing PCI |
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| Recruiting | 4 | 2334 | Europe | Prasugrel or Ticagrelor, Clopidogrel | Ludwig-Maximilians - University of Munich | Acute Coronary Syndrome, Atrial Fibrillation | 12/24 | 06/25 | | |
| Recruiting | 4 | 100 | Europe | RFR, FFR | Johannes Gutenberg University Mainz | Coronary Artery Disease | 06/25 | 06/25 | | |
| Recruiting | 4 | 2500 | Europe, RoW | Pressure Microcatheter guided strategy - PIOS MC, Pressure Wire guided strategy - PIOS - PW, Pressure Microcatheter guided strategy - Standard of care, Pressure Wire guided strategy - Standard of care | CoreAalst BV, Insight Lifetech Co., Ltd. | Coronary Artery Disease, Acute Coronary Syndrome | 06/26 | 06/30 | | |
| Completed | N/A | 185 | Europe | Comprehensive Cardiovascular magnetic resonance (CMR), Blood sampling, TTE (EchoErgo), Invasive pressure-volume (PV) Loops, Left ventricular (LV) biopsy | Goethe University, Deutsches Zentrum für Herz-Kreislauf-Forschung (DZHK) | Heart Failure With Normal Ejection Fraction | 12/22 | 12/22 | | |
| Completed | N/A | 20 | Europe | Swan-Ganz catheter placed in the coronary sinus - deflated, Swan-Ganz catheter placed in the coronary sinus - inflated | Johannes Gutenberg University Mainz | Microvascular Coronary Artery Disease | 08/23 | 08/23 | | |
MICAT, NCT02180178: Mainz Intracoronary Database. The Coronary Slow-flow and Microvascular Diseases Registry |
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| Recruiting | N/A | 1000 | Europe | observational only- no intervention | Johannes Gutenberg University Mainz | Coronary Artery Disease, Microvascular Dysfunction | 09/28 | 09/28 | | |
TIPTAP-I, NCT03714750: Treatment of Coronary Bifurcation Lesions: Comparing Reverse T and Protrusion Versus Double-kissing and Crush Stenting |
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| Completed | N/A | 50 | Europe | DK crush, Reverse TAP | Tommaso Gori | Coronary Artery Disease | 04/24 | 04/24 | | |
| Recruiting | N/A | 1000 | Europe | Assessment of microvascular function with intracoronary hemodilution | Johannes Gutenberg University Mainz | Microvascular Disease | 10/24 | 10/29 | | |
| Active, not recruiting | N/A | 399 | Europe, US | Shockwave Medical Coronary IVL System | Shockwave Medical, Inc. | Coronary Artery Disease | 12/24 | 04/28 | | |
| Recruiting | N/A | 144 | Europe | Coronary sinus reducer, Optimal medical therapy | Johannes Gutenberg University Mainz, Neovasc Inc. | Coronary Microvascular Disease, Refractory Angina | 10/25 | 10/29 | | |
| Not yet recruiting | N/A | 40 | Europe | microvascular function assessment | Johannes Gutenberg University Mainz | Microvascular Coronary Artery Disease | 07/27 | 08/27 | | |
| Recruiting | N/A | 1000 | Europe | Coronary physiology assessment, Parameters of coronary physiology in response to microvascular vasodilators (adenosine, papaverine) and acetylcholine | Johannes Gutenberg University Mainz | Coronary Microvascular Disease, Coronary Vasospasm | 08/28 | 08/28 | | |
| Schattenberg, Jörn M |
NATiV3, NCT04849728: A Phase 3 Study Evaluating Efficacy and Safety of Lanifibranor Followed by an Active Treatment Extension in Adult Patients With (NASH) and Fibrosis Stages F2 and F3 ( ) |
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| Recruiting | 3 | 1000 | Europe, Canada, US, RoW | IVA337, Lanifibranor, Placebo | Inventiva Pharma | NASH - Nonalcoholic Steatohepatitis | 09/25 | 09/26 | | |
| Recruiting | N/A | 100 | Europe | Intermittent fasting, Time restricted feeding, DGE diet | Johannes Gutenberg University Mainz, University of Turin, Italy | Fatty Liver Disease, Fatty Liver, Fatty Liver, Nonalcoholic | 09/24 | 12/24 | | |
| Recruiting | N/A | 1200 | Europe | UDCA, ursodeoxycholic acid, Ocaliva, obeticholic acid | University of Leipzig, RWTH Aachen University, Zentrum für Klinische Studien Leipzig, Intercept Pharma Europe Limited (IPEL), Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), University Hospital Erlangen, Medical care center for Gastroenterology, Berlin, Institute for Interdisciplinary Medicine, Hamburg, Leberhilfe Projekt gUG, Cologne, Hannover Medical School | PBC, Primary Biliary Cholangitis | 03/24 | 03/24 | | |
| Recruiting | N/A | 10000 | Europe | | Newcastle University, Newcastle-upon-Tyne Hospitals NHS Trust, Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Institute of Cardiometabolism and Nutrition, France, University of Cambridge, Örebro University, Sweden, University of Bern, University of Oxford, University of Turin, Italy, University of Angers, University Hospital, Antwerp, Linkoeping University, University of Helsinki, UMC Utrecht, National and Kapodistrian University of Athens, University of Lisbon, University of Milan, University of Palermo, Catholic University of the Sacred Heart, Wuerzburg University Hospital, RWTH Aachen University, University of Nottingham, Medical University of Vienna, University of Birmingham, University of Florence, Assistance Publique - Hôpitaux de Paris, University Medical Center Mainz | NAFLD, NASH, NASH - Nonalcoholic Steatohepatitis, Fibrosis, Liver, Steatosis of Liver, Hepatocellular Carcinoma, Cardiovascular Diseases, Type 2 Diabetes, Dyslipidaemia, Hypertension, Obesity, Other Associated Comorbidities | 12/30 | 12/30 | | |
| Grambihler, Annette |
| Active, not recruiting | 3 | 150 | Europe, US, RoW | Peginterferon Lambda-1a, Lambda, Peginterferon Lambda, Pegylated Interferon Lambda | Eiger BioPharmaceuticals, Eiger BioPharmaceuticals, Inc. | Hepatitis Delta Virus | 06/24 | 01/25 | | |
| Schattenberg, Joern |
| Terminated | 2b | 98 | Europe, Canada, US, RoW | EDP-305 1.5 mg, EDP-305, EDP-305 2 mg, Placebo | Enanta Pharmaceuticals, Inc, Enanta Pharmaceuticals, Inc. | Non-Alcoholic Steatohepatitis | 10/21 | 11/21 | | |
| Completed | 2 | 186 | Europe | ZED1227, Placebo | Dr. Falk Pharma GmbH, Dr. Falk Pharma GmbH | NAFLD, Liver Fibrosis | 06/23 | 07/23 | | |
| Active, not recruiting | N/A | 450 | Europe, US | | University of Oxford, Newcastle University, University of Nottingham, University of Cambridge, University of Seville, Pinnacle Clinical Research, PLLC, ICAN Nutrition Education and Research, Assistance Publique - Hôpitaux de Paris, University of Angers, University of Palermo, University of Turin, Italy, University Medical Center Mainz, University of Helsinki, University of Bern, Linkoeping University, Perspectum, Antaros Medical, Resoundant Inc, Pfizer, Novartis, Takeda, Boehringer Ingelheim, Intercept Pharmaceuticals, Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | NAFLD, NASH, NASH - Nonalcoholic Steatohepatitis, Fibrosis, Liver, Steatosis of Liver | 10/24 | 10/24 | | |
NASH-Biomarker, NCT05312853: Evaluating the Diagnostic and Predictive Value of Non-invasive Tests (NITs) on the Progression of Chronic Liver Disease. |
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| Not yet recruiting | N/A | 250 | Europe | | Johannes Gutenberg University Mainz, Boehringer Ingelheim, Nordic Bioscience A/S | Chronic Liver Disease | 04/34 | 12/34 | | |
