The Ohio State University Wexner Medical Center
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 512 Trials 
1938 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Carbone, David P
NCT05376891: Met Non Small Cell Cancer Registry (MOMENT)

Recruiting
N/A
700
Europe, Canada, US, RoW
EMD Serono Research & Development Institute, Inc., Merck KGaA, Darmstadt, Germany
Cancer
03/27
03/27
Otterson, Gregory A
ALCHEMIST, NCT02201992: Crizotinib in Treating Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been Removed by Surgery and ALK Fusion Mutations (An Treatment Trial)

Recruiting
3
168
US, RoW
Clinical Observation, Crizotinib, MET tyrosine kinase inhibitor PF-02341066, PF-02341066, PF-2341066, Xalkori, Laboratory Biomarker Analysis
ECOG-ACRIN Cancer Research Group, National Cancer Institute (NCI)
ALK Gene Rearrangement, ALK Gene Translocation, ALK Positive, Stage IB Non-Small Cell Lung Carcinoma AJCC v7, Stage II Non-Small Cell Lung Cancer AJCC v7, Stage IIA Non-Small Cell Lung Carcinoma AJCC v7, Stage IIB Non-Small Cell Lung Carcinoma AJCC v7, Stage IIIA Non-Small Cell Lung Cancer AJCC v7
05/36
05/36
ETCTN Study 10166, NCT03600701: Atezolizumab and Cobimetinib in Treating Patients With Metastatic, Recurrent, or Refractory Non-small Cell Lung Cancer

Active, not recruiting
2
48
US
Atezolizumab, MPDL 3280A, MPDL 328OA, MPDL-3280A, MPDL3280A, MPDL328OA, RG 7446, RG-7446, RG7446, RO 5541267, RO-5541267, RO5541267, Tecentriq, Biopsy, BIOPSY_TYPE, Bx, Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Cobimetinib, Cotellic, GDC 0973, GDC-0973, GDC0973, MEK Inhibitor GDC-0973, XL 518, XL-518, XL518, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Magnetic Resonance Imaging, Magnetic Resonance, Magnetic Resonance Imaging (MRI), Magnetic resonance imaging (procedure), Magnetic Resonance Imaging Scan, Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance, MR, MR Imaging, MRI, MRI Scan, MRIs, NMR Imaging, NMRI, Nuclear Magnetic Resonance Imaging, sMRI, Structural MRI
National Cancer Institute (NCI)
Metastatic Lung Non-Small Cell Carcinoma, Recurrent Lung Non-Small Cell Carcinoma, Refractory Lung Non-Small Cell Carcinoma, Stage IV Lung Cancer AJCC v8
07/25
07/25
A151804, NCT04242095: Collection of Research Data and Samples from Patients Who Experience Immunotherapy Side Effects

Recruiting
N/A
240
US
Biospecimen Collection, Medical Chart Review
Alliance for Clinical Trials in Oncology, National Cancer Institute (NCI)
Malignancy
10/26
10/26
ALCHEMIST Screening, NCT02194738: Genetic Testing in Screening Patients With Stage IB-IIIA Non-small Cell Lung Cancer That Has Been or Will Be Removed by Surgery (The Trial)

Recruiting
N/A
8300
US, RoW
Biospecimen Collection, Biological Sample Collection, Biospecimen Collected, Specimen Collection, Carboplatin, Blastocarb, Carboplat, Carboplatin Hexal, Carboplatino, Carboplatinum, Carbosin, Carbosol, Carbotec, CBDCA, Displata, Ercar, JM-8, JM8, Nealorin, Novoplatinum, Paraplatin, Paraplatin AQ, Paraplatine, Platinwas, Ribocarbo, Cisplatin, Abiplatin, Blastolem, Briplatin, CDDP, Cis-diammine-dichloroplatinum, Cis-diamminedichloridoplatinum, Cis-diamminedichloro Platinum (II), Cis-diamminedichloroplatinum, Cis-dichloroammine Platinum (II), Cis-platinous Diamine Dichloride, Cis-platinum, Cis-platinum II, Cis-platinum II Diamine Dichloride, Cismaplat, Cisplatina, Cisplatinum, Cisplatyl, Citoplatino, Citosin, Cysplatyna, DDP, Lederplatin, Metaplatin, Neoplatin, Peyrone's Chloride, Peyrone's Salt, Placis, Plastistil, Platamine, Platiblastin, Platiblastin-S, Platinex, Platinol, Platinol- AQ, Platinol-AQ, Platinol-AQ VHA Plus, Platinoxan, Platinum, Platinum Diamminodichloride, Platiran, Platistin, Platosin, Clinical Observation, observation, Computed Tomography, CAT, CAT Scan, Computed Axial Tomography, Computerized Axial Tomography, Computerized axial tomography (procedure), Computerized Tomography, Computerized Tomography (CT) scan, CT, CT Scan, tomography, Crizotinib, Alkixen, Crizocent, MET Tyrosine Kinase Inhibitor PF-02341066, PF 02341066, PF-02341066, PF-2341066, PF02341066, Xalkori, Cytology Specimen Collection Procedure, Cytologic Sampling, Echocardiography, EC, Erlotinib, Gemcitabine Hydrochloride, dFdCyd, Difluorodeoxycytidine Hydrochloride, Gemcitabine HCI, Gemzar, LY 188011, LY-188011, LY188011, Nivolumab, ABP 206, BCD-263, BMS 936558, BMS-936558, BMS936558, CMAB819, MDX 1106, MDX-1106, MDX1106, NIVO, Nivolumab Biosimilar ABP 206, Nivolumab Biosimilar BCD-263, Nivolumab Biosimilar CMAB819, ONO 4538, ONO-4538, ONO4538, Opdivo, Paclitaxel, Anzatax, Asotax, Bristaxol, Praxel, Taxol, Taxol Konzentrat, Pembrolizumab, BCD-201, GME 751, GME751, Keytruda, Lambrolizumab, MK 3475, MK-3475, MK3475, Pembrolizumab Biosimilar BCD-201, Pembrolizumab Biosimilar GME751, Pembrolizumab Biosimilar QL2107, Pembrolizumab Biosimilar RPH-075, QL2107, RPH 075, RPH-075, RPH075, SCH 900475, SCH-900475, SCH900475, Pemetrexed, MTA, Multitargeted Antifolate, Pemfexy, Pemetrexed Disodium, Alimta, Almita, LY231514, N-[4-[2-(2-Amino-4,7-dihydro-4-oxo-1H-pyrrolo[2,3-d]pyrimidin-5-yl)ethyl]benzoyl]-L-glutamic Acid Disodium Salt, Placebo Administration, Positron Emission Tomography, Medical Imaging, Positron Emission Tomography, PET, PET Scan, Positron emission tomography (procedure), Positron Emission Tomography Scan, Positron-Emission Tomography, proton magnetic resonance spectroscopic imaging, PT
National Cancer Institute (NCI)
Stage IB Lung Non-Small Cell Carcinoma AJCC v7, Stage II Lung Non-Small Cell Cancer AJCC v7, Stage IIA Lung Cancer AJCC v8, Stage IIB Lung Cancer AJCC v8, Stage IIIA Lung Cancer AJCC v8, Stage IIIA Lung Non-Small Cell Cancer AJCC v7, Stage IIIB Lung Cancer AJCC v8
09/26
09/26
Coccaro, Emil F
LPSS, NCT06665074: Inflammatory Challenge in Human Aggression.

Not yet recruiting
2
112
US
Endotoxin (E. coli O:113, Reference Endotoxin), Saline (Placebo)
Ohio State University, National Institute of Mental Health (NIMH)
Intermittent Explosive Disorder
07/29
01/30
NCT06118567: Effect of Nitrous Oxide on Aggression.

Recruiting
2
50
US
Nitrous oxide, Room Air
Ohio State University, National Institute of Mental Health (NIMH)
Intermittent Explosive Disorder
08/25
08/25
NCT06118580: Neural Correlates During Alcohol Intoxication

Recruiting
2
144
US
Alcohol (Ethanol), Placebo
Ohio State University, National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Alcohol Use Disorder, Intermittent Explosive Disorder
08/25
08/26
NCT05895513: Pimavanserin and Aggression and Social Cognition.

Recruiting
2
35
US
Pimavanserin 34 mg, Nuplazid, Placebo
Ohio State University, ACADIA Pharmaceuticals Inc.
Intermittent Explosive Disorder
01/26
01/26
Lasky, Joseph L
TETON, NCT04708782: Study of Efficacy and Safety of Inhaled Treprostinil in Subjects With Idiopathic Pulmonary Fibrosis

Hourglass May 2024 - Aug 2024 : Topline data for IPF
Hourglass Jan 2023 - Mar 2023 : Enrollment completion of TETON trial for IPF
Recruiting
3
576
Canada, US
Placebo, Inhaled Treprostinil, Tyvaso, Treprostinil Ultrasonic Nebulizer
United Therapeutics
Idiopathic Pulmonary Fibrosis, Interstitial Lung Disease
06/25
06/25
RedeS, NCT03037164: INTERCEPT Blood System for RBCs Study in Regions at Potential Risk for Zika Virus Transfusion-Transmitted Infections

Recruiting
3
800
US
INTERCEPT Blood System for Red Blood Cells, Conventional (Control)
Cerus Corporation
Anemia
10/25
01/26
PRECISIONS, NCT04300920: Prospective Treatment Efficacy in IPF Using Genotype for Nac Selection () Trial

Active, not recruiting
3
202
US
N-acetyl cysteine, NAC, Placebo
Weill Medical College of Cornell University, University of Virginia, University of Michigan, Pulmonary Fibrosis Foundation, University of Washington, National Heart, Lung, and Blood Institute (NHLBI), Three Lakes Foundation
Idiopathic Pulmonary Fibrosis
02/26
02/26
TETON-PPF, NCT05943535: Study of the Efficacy and Safety of Inhaled Treprostinil in Subjects With Progressive Pulmonary Fibrosis

Recruiting
3
698
Canada, US, RoW
Placebo, Inhaled Treprostinil, Tyvaso, Treprostinil Ultrasonic Nebulizer
United Therapeutics
Progressive Pulmonary Fibrosis, Interstitial Lung Disease
11/27
11/27
GKT137831, NCT03865927: in IPF Patients with Idiopathic Pulmonary Fibrosis

Hourglass Jul 2024 - Dec 2024 : Data from trial for IPF
Completed
2
58
US
Placebo Oral Tablet, GKT137831
University of Alabama at Birmingham, Temple University, Tulane University, University of Michigan
Idiopathic Pulmonary Fibrosis
11/24
11/24
NCT05671835: Study of TTI-101 in Participants With Idiopathic Pulmonary Fibrosis

Recruiting
2
75
US
TTI-101, Placebo
Tvardi Therapeutics, Incorporated
Idiopathic Pulmonary Fibrosis
03/25
07/25
Zeuzem, Stefan
D-LIVR, NCT03719313 / 2018-003167-54: Study of the Efficacy and Safety of Lonafarnib / Ritonavir With and Without Pegylated Interferon -Alfa-2a

Completed
3
407
Europe, Canada, US, RoW
Lonafarnib, EBP994, Sarasar, LNF, Ritonavir, Norvir, RTV, PEG IFN-alfa-2a, Pegasys, pegylated interferon-alfa, Placebo Lonafarnib, Placebo Ritonavir
Eiger BioPharmaceuticals
Hepatitis Delta Virus
10/22
03/23
NCT03866187 / 2017-001452-55: Safety, Efficacy, Immunogenicity Study of GSK Biologicals' HBV Viral Vector and Adjuvanted Proteins Vaccine (GSK3528869A) in Adult Patients With Chronic Hepatitis B Infection

Terminated
1/2
135
Europe, RoW
ChAd155-hIi-HBV low dose formulation, ChAd155-hIi-HBV high dose formulation, HBc-HBs/AS01B-4 low dose formulation, HBc-HBs/AS01B-4 high dose formulation, MVA-HBV low dose formulation, MVA-HBV high dose formulation, Placebo
GlaxoSmithKline, GlaxoSmithKline Biologicals
Hepatitis B, Chronic
10/24
10/24
PBC-Cohort, NCT04076527 / 2016-004141-90: Prospective, Multicenter Cohort Study on Primary Biliary Cholangitis

Recruiting
N/A
1200
Europe
UDCA, ursodeoxycholic acid, Ocaliva, obeticholic acid
University of Leipzig, RWTH Aachen University, Zentrum für Klinische Studien Leipzig, Intercept Pharma Europe Limited (IPEL), Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), University Hospital Erlangen, Medical care center for Gastroenterology, Berlin, Institute for Interdisciplinary Medicine, Hamburg, Leberhilfe Projekt gUG, Cologne, Hannover Medical School
PBC, Primary Biliary Cholangitis
03/24
03/24
NCT04721665: German SLD-Registry (Deutsches SLD-Register)

Recruiting
N/A
5000
Europe
Leberstiftungs-GmbH Deutschland
Steatotic Liver Disease
11/26
11/36
NCT02815891: A Longitudinal Observational Study of Patients With Nonalcoholic Steatohepatitis (NASH) and Related Conditions Across the Entire Spectrum of Nonalcoholic Fatty Liver Disease (NAFLD)

Recruiting
N/A
15000
Europe, US
Target PharmaSolutions, Inc.
Nonalcoholic Fatty Liver, Nonalcoholic Steatohepatitis
07/36
07/36
Conen, David
ASPIRE-AF, NCT03968393 / 2019-001336-62: Anticoagulation for Stroke Prevention In Patients With Recent Episodes of Perioperative AF After Noncardiac Surgery

Recruiting
4
2270
Europe, Canada, RoW
Non-vitamin K oral anticoagulant (NOAC), Apixaban, Dabigatran, Edoxaban, Rivaroxaban
Population Health Research Institute, Hamilton Health Sciences Corporation
Stroke, Atrial Fibrillation
12/26
12/28
NCT03310125 / 2017-003836-35: Colchicine For The Prevention Of Perioperative Atrial Fibrillation In Patients Undergoing Thoracic Surgery (COP-AF)

Completed
3
3209
Europe, Canada, US, RoW
Colchicine, Placebo
Population Health Research Institute, Hamilton Health Sciences Corporation
Atrial Fibrillation, Atrial Flutter, Myocardial Injury After Non-Cardiac Surgery
07/23
07/23
PROTECT-HF, NCT03541616: Prevalence of Subclinical Atrial Fibrillation in Heart Failure Patients and Its Relationship With Hospital Readmission

Completed
N/A
242
Canada
ECG Patch, pocket ECG monitor
Population Health Research Institute, Heart and Stroke Foundation of Canada, Canadian Cardiovascular Society
Heart Failure, Atrial Fibrillation
01/22
03/23
DETECT-POAF, NCT06519747: DETECTion of PeriOperative Atrial Fibrillation After Noncardiac Surgery

Recruiting
N/A
750
Canada
Cardiac monitoring device
Population Health Research Institute
Atrial Fibrillation, Atrial Flutter
08/26
12/26
SWISS-AF, NCT02105844: Swiss Atrial Fibrillation Cohort Study

Active, not recruiting
N/A
2415
Europe
University Hospital, Basel, Switzerland, Swiss National Science Foundation, Medical Image Analysis Center (MIAC) Basel, Schiller AG Baar, Clinical Trial Unit, University Hospital Basel, Switzerland, Cardiovascular Research Institute (CRIB) Basel, Cardiocentro Ticino
Atrial Fibrillation
03/30
03/30
Evans, David
NCT06178679: Safety and Efficacy of ST-100 (Vezocolmitide) Ophthalmic Solution 60 μg/ml Ophthalmic Solution in Subjects Diagnosed With Dry Eye Disease (DED)

Recruiting
3
175
US
ST-100 (vezocolmitide), Vehicle
ORA, Inc., Stuart Therapeutics, Inc.
Dry Eye Disease
06/24
07/24
NCT05927753: Study to Evaluate the Clinical Performance of Deseyne (Vifilcon C) Daily Disposable Soft Contact Lens

Completed
N/A
81
US
Deseyne Daily Disposable Contact Lens (Test Device)
Bruno Vision Care
Refractive Error - Myopia Bilateral
01/24
01/24
Devereaux, PJ
ASPIRE-AF, NCT03968393 / 2019-001336-62: Anticoagulation for Stroke Prevention In Patients With Recent Episodes of Perioperative AF After Noncardiac Surgery

Recruiting
4
2270
Europe, Canada, RoW
Non-vitamin K oral anticoagulant (NOAC), Apixaban, Dabigatran, Edoxaban, Rivaroxaban
Population Health Research Institute, Hamilton Health Sciences Corporation
Stroke, Atrial Fibrillation
12/26
12/28
POISE-3, NCT03505723 / 2018-000539-29: PeriOperative ISchemic Evaluation-3 Trial

Completed
3
9535
Europe, Canada, US, RoW
Tranexamic Acid, TXA, Placebo (Saline), saline, Perioperative hypotension-avoidance strategy, Perioperative hypertension-avoidance strategy
Population Health Research Institute
Perioperative Bleeding, Venous Thrombosis, Arterial Thrombosis
11/21
02/23
NCT03310125 / 2017-003836-35: Colchicine For The Prevention Of Perioperative Atrial Fibrillation In Patients Undergoing Thoracic Surgery (COP-AF)

Completed
3
3209
Europe, Canada, US, RoW
Colchicine, Placebo
Population Health Research Institute, Hamilton Health Sciences Corporation
Atrial Fibrillation, Atrial Flutter, Myocardial Injury After Non-Cardiac Surgery
07/23
07/23
PLAN, NCT04874038: Prevention of Persistent Pain With LidocAine iNfusions in Breast Cancer Surgery

Recruiting
3
1602
Canada, RoW
Lidocaine 20mg/ml, Lidocaine 2%, Placebo, 0.9% sodium chloride solution
University Health Network, Toronto, Canadian Institutes of Health Research (CIHR)
Post-mastectomy Pain Syndrome, Breast Cancer, Pain, Postoperative, Pain, Chronic
06/25
06/26
ACHIEVE, NCT03020303 / 2020-001882-36: Aldosterone BloCkade for Health Improvement EValuation in End-stage Renal Disease

Recruiting
3
2750
Europe, Canada, RoW
Spironolactone 25Mg Tablet, Placebo Oral Tablet
Population Health Research Institute, Canadian Institutes of Health Research (CIHR)
Endstage Renal Disease
07/25
04/26
NCT04540276: Intraoperative Hyperoxia and MINS

Active, not recruiting
N/A
7700
Europe, Canada, US, RoW
Inspiratory oxygen fraction
University Hospital Bispebjerg and Frederiksberg, Population Health Research Institute
Hyperoxia, Myocardial Infarction, Myocardial Injury
10/20
03/21
PVC-RAM, NCT04344665: Post Discharge After Surgery Virtual Care With Remote Automated Monitoring Technology () Trial

Completed
N/A
905
Canada
Virtual Care and Remote Automated Monitoring
Population Health Research Institute, Hamilton Health Sciences Corporation, McMaster University
Surgery, Perioperative Complication, COVID
10/20
06/21
NCT01842568: Vascular Events In Surgery patIents cOhort evaluatioN - Cardiac Surgery

Active, not recruiting
N/A
15989
Europe, Canada, US, RoW
Population Health Research Institute, Abbott Diagnostics Division
Vascular Death, Myocardial Infarction, Stroke, Cardiac Surgery
05/22
12/25
PVC-RAM-3, NCT05171569: Post Discharge After Surgery Virtual Care With Remote Automated Monitoring Technology-3 Trial

Recruiting
N/A
2500
Canada
Virtual care with remote automated monitoring (RAM)
Population Health Research Institute, Hamilton Health Sciences Corporation
Surgery
01/25
02/25
PVC-RAM-2, NCT04876950: Post Discharge After Surgery Virtual Care with Remote Automated Monitoring Technology-2 () Trial

Recruiting
N/A
2000
Canada
Virtual care with remote automated monitoring
Population Health Research Institute
Surgery, Perioperative Complication
12/25
03/26
HIP ATTACK-2, NCT04743765: HIP Fracture Accelerated Surgical TreaTment and Care TracK 2 Trial

Recruiting
N/A
1100
Europe, Canada, US, RoW
Accelerated medical clearance and surgery
Population Health Research Institute, Canadian Institutes of Health Research (CIHR), National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Hip Fractures, Myocardial Injury
02/27
05/27
Hill, Michael D
PLATINUM, NCT04443608: Patiromer Utility as an Adjunct Treatment in Patients Needing Urgent Hyperkalemia Management

Terminated
4
115
US
Patiromer Powder for Oral Suspension [Veltassa], Active drug, Placebo, Inactive substance
Comprehensive Research Associates
Hyperkalemia
03/23
06/23
ESCAPE-NEXT, NCT04462536 / 2020-002360-30: Efficacy and Safety of Nerinetide in Participants With Acute Ischemic Stroke Undergoing Endovascular Thrombectomy Excluding Thrombolysis

Completed
3
850
Europe, Canada, US, RoW
Placebo, Nerinetide, NA-1
NoNO Inc., University of Calgary
Stroke, Acute
08/23
08/23
ACT-WHEN, NCT06320431: ACT-GLOBAL THROMBOLYSIS (-001) Domain Within the ACT-GLOBAL Adaptive Platform Trial-NCT06352632

Recruiting
3
4000
Canada, RoW
Tenecteplase, TNKase, Metalyse
University of Calgary, The George Institute for Global Health, Australia
Acute Ischemic Stroke AIS, Stroke Acute, Stroke, Acute, Stroke Ischemic
09/30
12/30
ACT-GLOBAL, NCT06352632: Adaptive Platform Trial for Stroke

Recruiting
3
20000
Canada, RoW
Standard-dose intravenous tenecteplase, Low-dose intravenous tenecteplase, No intravenous tenecteplase, Conservative Blood Pressure Control, Moderate Blood Pressure Control, Intensive Blood Pressure Control, Placebo, NoNO-42, No deferoxamine mesylate and no colchicine, Deferoxamine mesylate only, Colchicine only, Both deferoxamine mesylate and colchicine
The George Institute, University of Calgary, Berry Consultants
Stroke
09/34
09/34
TEMPO-2, NCT02398656: A Randomized Controlled Trial of TNK-tPA Versus Standard of Care for Minor Ischemic Stroke With Proven Occlusion

Completed
3
1274
Europe, Canada, RoW
Tenecteplase, TNK-tPA, Antiplatelet treatment, ASA, Clopidogrel
University of Calgary
Stroke, Acute
01/24
04/24
ENDOLOW, NCT04167527: Endovascular Therapy for Low NIHSS Ischemic Strokes

Recruiting
2/3
200
Europe, Canada, US
Immediate mechanical thrombectomy(iMT) using EmboTrap Revascularization Device, EmboTrap III, Initial medical management (iMM)
Emory University, University of Calgary, University of Cincinnati, Heidelberg University, Children's Hospital Medical Center, Cincinnati
Cerebral Ischemia
12/24
12/24
NCT05123755: Phase 2a Multiple Ascending Dose Study in Hospitalized Patients With Pneumonia.

Recruiting
2a
120
US
AV-001 Injection, AV-001 Placebo Injection
Vasomune Therapeutics, Inc.
Acute Respiratory Distress Syndrome, Viral or Bacterial Infections, Pneumonia, Pneumonia, Viral, Respiratory Infection, COVID-19 Acute Respiratory Distress Syndrome
12/24
03/25
KOURAGE, NCT06374797: A Study of Auxora in Patients with AKI and Injurious Lung "Crosstalk"

Recruiting
2
150
US
Auxora, Placebo
CalciMedica, Inc.
Acute Kidney Injury
08/25
08/25
RAISE, NCT06226805: Study of BB-031 in Acute Ischemic Stroke Patients

Recruiting
2
156
US, RoW
BB-031, DTRI-031, Placebo, Saline
Basking Biosciences, Inc.
Acute Ischemic Stroke
12/26
03/27
CARPO, NCT04681066: A Study of Auxora in Patients With Acute Pancreatitis and Accompanying SIRS

Completed
2
216
US, RoW
CM-4620 Injectable Emulsion or CM-4620-IE, Auxora, Placebo
CalciMedica, Inc.
Acute Pancreatitis, Systemic Inflammatory Response Syndrome
05/24
05/24
NCT06403267: NoNO-42 Trial in Acute Ischemic Stroke Patients Selected for Thrombolysis with or Without Endovascular Thrombectomy

Recruiting
2
600
Canada
NoNO-42, Placebo, Control
NoNO Inc.
Acute Ischemic Stroke
05/26
05/26
ACST-2, NCT00883402: Carotid Endarterectomy Versus Carotid Artery Stenting in Asymptomatic Patients

Active, not recruiting
N/A
3638
Europe, Canada, Japan, US, RoW
CEA, CAS
University of Oxford, NHS Health Technology Assessment Programme, BUPA Foundation, British Heart Foundation
Carotid Stenosis
12/20
12/25
Tension, NCT03094715: Efficacy and Safety of Thrombectomy in Stroke With Extended Lesion and Extended Time Window

Terminated
N/A
253
Europe, Canada, RoW
Thrombectomy, Mechanical thrombectomy, Best medical care, Control group
University Hospital Heidelberg, Karolinska University Hospital, Eppdata GmbH Hamburg, Germany, Aarhus University Hospital, Medical University Innsbruck, Groupe Hospitalier Pitie-Salpetriere, Oslo University Hospital, University Hospital, Martin, Charles University, Czech Republic, Hospices Civils de Lyon, CHU de Reims, Epidemiological and Clinical Research Information Network, STROKE ALLIANCE FOR EUROPE, International Consortium for Health Outcome Measurement, Inc., Europan Society for Minimally Invasive Neurological Therapy, Universitätsklinikum Hamburg-Eppendorf
Stroke, Acute, Cerebral Stroke, Cerebrovascular Stroke, Apoplexy; Brain
05/23
11/23
ENCHANTED3/MT, NCT06352619: Third Enhanced Control of Hypertension and Thrombectomy Stroke Domain Within ACT-GLOBAL Adaptive Platform Trial

Recruiting
N/A
2000
Canada, RoW
Conservative SBP Control, Moderate SBP Control, Intensive SBP Control
The George Institute, University of Calgary, Changhai Hospital
Ischemic Stroke, Acute
05/26
05/26
Heathcock, Jill C
I-ACQUIRE, NCT03910075: Perinatal Arterial Stroke: A Multi-site RCT of Intensive Infant Rehabilitation

Active, not recruiting
3
216
US
I-ACQUIRE - High Dosage, ACQUIRE, Pediatric Constraint-Induced Movement Therapy, P-CIMT, I-ACQUIRE - Moderate Dosage, Usual & Customary Treatment (U&CT)
Virginia Polytechnic Institute and State University, Ohio State University, Nationwide Children's Hospital, Stanford University, University of Cincinnati, Medical University of South Carolina
Perinatal Stroke, Hemiparesis
10/25
05/26
DRIVE, NCT02857933: Daily and Weekly Rehabilitation Delivery for Young Children With Gross Motor Delays

Active, not recruiting
N/A
75
US
Physical Therapy
Ohio State University
Gross Motor Development Delay
10/24
04/26
NCT06810063: Feasibility and Reliability of the Melbourne Assessment-2 (MA-2) for Telehealth

Recruiting
N/A
35
US
Assessment only, no intervention
Ohio State University
Cerebral Palsy, Hemiplegic Cerebral Palsy
05/26
05/26
CHAMP-T, NCT05303883: Feasibility of Pediatric CIMT by Televideo

Completed
N/A
12
US
Pediatric Constrained Induced Movement Therapy
Ohio State University, Nationwide Children's Hospital, Virginia Polytechnic Institute and State University
Hemiplegic Cerebral Palsy
10/23
10/23
NCT06486987: CHAMP T 2 Pilot of CIMT by Tele-Video

Recruiting
N/A
10
US
Constraint induced movement therapy delivered by televideo
Warren Lo, Ohio State University, Virginia Polytechnic Institute and State University
Hemiplegic Cerebral Palsy
12/26
06/27
Lee, Peter J Barrett
PERT-AP, NCT06477159: Pancreatic Enzyme Replacement Therapy for Acute Pancreatitis-Associated Exocrine Pancreatic Insufficiency

Recruiting
4
60
US
Pancrelipase Capsules, CREON
Ohio State University, University of Pittsburgh, University of Illinois Chicago, University of Southern California, New York University, AbbVie
Exocrine Pancreatic Insufficiency
12/26
07/27
SHINE-ON, NCT04844606 / 2020-005311-49: A Master Protocol (AMAZ): A Study of Mirikizumab (LY3074828) in Pediatric Participants With Ulcerative Colitis or Crohn's Disease

Recruiting
3
150
Europe, Japan, US, RoW
Mirikizumab, LY3074828
Eli Lilly and Company, Eli Lilly and Company
Ulcerative Colitis, Ulcerative Colitis Chronic, Inflammatory Bowel Diseases, Crohn's Disease
07/30
07/30
EQuiPP, NCT05012150: A Pilot Study in Endoscopic Therapy on Quality of Life and Pain in Chronic Pancreatitis

Recruiting
N/A
32
US
Ohio State University, American Society for Gastrointestinal Endoscopy
Chronic Pancreatitis
06/24
06/25
MoSAIC, NCT05878236: iMmune SignAtures and Clinical outComes in AP

Recruiting
N/A
198
US
CyTOF Analysis
Ohio State University, University of Pittsburgh, University of Illinois at Chicago, University of Southern California, Benaroya Research Institute
Acute Pancreatitis
12/26
12/27
Hill, Nicholas
NCT03992755: Extension Study for Participants in LIQ861 Trials to Evaluate the Long-term Safety of Dry Powder Inhalation of Treprostinil

Active, not recruiting
3
92
US
LIQ861 Inhaled Treprostinil, Inhaled treprostinil, Inhaled prostacyclin
Liquidia Technologies, Inc., Nuventra, Inc.
Primary Pulmonary Hypertension
05/25
05/25
NCT03626688 / 2018-001187-33: A Study Evaluating the Efficacy and Safety of Ralinepag to Improve Treatment Outcomes in PAH Patients

Recruiting
3
1000
Europe, Canada, US, RoW
Ralinepag, APD811, Placebo
United Therapeutics
PAH, Pulmonary Hypertension, Pulmonary Arterial Hypertension, Hypertension, Connective Tissue Diseases, Familial Primary Pulmonary Hypertension, Vascular Diseases, Cardiovascular Diseases, Hypertension, Pulmonary, Lung Diseases, Respiratory Tract Disease
12/25
12/25
TETON, NCT04708782: Study of Efficacy and Safety of Inhaled Treprostinil in Subjects With Idiopathic Pulmonary Fibrosis

Hourglass May 2024 - Aug 2024 : Topline data for IPF
Hourglass Jan 2023 - Mar 2023 : Enrollment completion of TETON trial for IPF
Recruiting
3
576
Canada, US
Placebo, Inhaled Treprostinil, Tyvaso, Treprostinil Ultrasonic Nebulizer
United Therapeutics
Idiopathic Pulmonary Fibrosis, Interstitial Lung Disease
06/25
06/25
IMPAHCT-FUL, NCT05557942 / 2021-006864-25: Inhaled Imatinib Pulmonary Arterial Hypertension Clinical Trial - Follow Up Long Term Extension

Terminated
3
186
Europe, Canada, US, RoW
AV-101
Aerovate Therapeutics, Aerovate Therapeutics Inc
Pulmonary Arterial Hypertension
08/24
08/24
TETON-PPF, NCT05943535: Study of the Efficacy and Safety of Inhaled Treprostinil in Subjects With Progressive Pulmonary Fibrosis

Recruiting
3
698
Canada, US, RoW
Placebo, Inhaled Treprostinil, Tyvaso, Treprostinil Ultrasonic Nebulizer
United Therapeutics
Progressive Pulmonary Fibrosis, Interstitial Lung Disease
11/27
11/27
IMPAHCT, NCT05036135 / 2021-001910-13: A Study of AV-101 (Dry Powder Inhaled Imatinib) in Patients With Pulmonary Arterial Hypertension (PAH)

Terminated
2/3
202
Europe, Canada, US, RoW
AV-101, Placebo
Aerovate Therapeutics, Aerovate Therapeutics, Inc.
Pulmonary Arterial Hypertension
08/24
08/24
ELEVATE 2, NCT04712669 / 2020-004971-42: A Study of Rodatristat Ethyl in Patients With Pulmonary Arterial Hypertension

Completed
2
108
Europe, Canada, US, RoW
rodatristat ethyl 300 mg tablet BID, rodatristat ethyl 600 mg BID, Placebo
Altavant Sciences GmbH
Pulmonary Arterial Hypertension
06/23
08/23
NCT02114944: Treatment of Dyspnea in Do-not-intubate Patients

Active, not recruiting
N/A
400
Europe, US
NIV, CPAP, Standard oxygen, HFNC, High-flow nasal cannula
Tufts Medical Center, Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Acute Respiratory Failure, Acute on Chronic Respiratory Failure, Dyspnea
09/20
12/23
NCT04217746: Effects of High Flow Nasal Cannula on Sputum Clearance in Acute Exacerbation of Chronic Obstructive Pulmonary Disease

Active, not recruiting
N/A
40
US
High Flow Nasal Cannula, Fisher and Paykel AIRVO humidified high flow system
Tufts Medical Center, Virginia Commonwealth University
Chronic Obstructive Pulmonary Disease, COPD Exacerbation, Airflow Obstruction
02/25
02/25
NCT05108896: Aspiration in Acute Respiratory Failure Survivors 2

Recruiting
N/A
855
US
3-Screenings Protocol, Modified bedside swallow exam (BSE), Three Screening Tests, FEES, Fiberoptic Endoscopic Evaluation of Swallowing, Tracheal Ultrasound
University of Colorado, Denver, National Institute of Nursing Research (NINR)
Dysphagia, Aspiration
12/25
12/25
NCT05204888: MyAirvo 3 (High Flow Nasal Therapy; HFNT) for COPD Patients in the Home

Recruiting
N/A
642
Canada, US
myAirvo3, Pulse oximeter
Temple University, Fisher and Paykel Healthcare
COPD
01/27
03/27
PVDOMICS, NCT02980887: Pulmonary Vascular Disease Phenomics Program

Active, not recruiting
N/A
1195
US
No Intervention
The Cleveland Clinic, Brigham and Women's Hospital, Columbia University, Weill Medical College of Cornell University, Johns Hopkins University, Mayo Clinic, University of Arizona, Vanderbilt University
Pulmonary Arterial Hypertension
12/29
12/29
Girgis, Reda E
NCT03626688 / 2018-001187-33: A Study Evaluating the Efficacy and Safety of Ralinepag to Improve Treatment Outcomes in PAH Patients

Recruiting
3
1000
Europe, Canada, US, RoW
Ralinepag, APD811, Placebo
United Therapeutics
PAH, Pulmonary Hypertension, Pulmonary Arterial Hypertension, Hypertension, Connective Tissue Diseases, Familial Primary Pulmonary Hypertension, Vascular Diseases, Cardiovascular Diseases, Hypertension, Pulmonary, Lung Diseases, Respiratory Tract Disease
12/25
12/25
LAMBDA 002, NCT05170425: (Lung Registry) Study

Active, not recruiting
N/A
154
US
Prospera
Natera, Inc.
Lung Transplant Rejection
08/26
05/27
Cohen, Jonathan
NCT05894577: ACTIV-6: COVID-19 Study of Repurposed Medications - Arm F (Montelukast)

Completed
3
1453
US
Placebo, Montelukast
Susanna Naggie, MD, National Center for Advancing Translational Sciences (NCATS), Vanderbilt University Medical Center
Covid19
07/23
01/24
NCT04885530: ACTIV-6: COVID-19 Study of Repurposed Medications

Completed
3
10956
US
Ivermectin, Ivermectin Tablets, Fluvoxamine, Fluvoxamine Maleate Tablets, Fluticasone, Fluticasone Furoate, Placebo, Montelukast, Metformin
Susanna Naggie, MD, National Center for Advancing Translational Sciences (NCATS), Vanderbilt University Medical Center
Covid19
04/24
04/24
RECONNECT, NCT04977986 / 2021-002542-33: Clinical Study of Cannabidiol in Children, Adolescents, and Young Adults with Fragile X Syndrome

Recruiting
3
250
Europe, US, RoW
ZYN002 - transdermal gel, cannabidiol formulated as a clear gel that can be applied to the skin (transdermal delivery), Placebo, Placebo Comparator, Matching Placebo
Zynerba Pharmaceuticals, Inc., Zynerba Pharmaceuticals, Inc.
Fragile X Syndrome
05/25
05/25
NCT06042855: ACTIV-6: COVID-19 Study of Repurposed Medications - Arm G (Metformin)

Completed
3
3214
US
Placebo, Metformin
Susanna Naggie, MD, National Center for Advancing Translational Sciences (NCATS), Vanderbilt University Medical Center
Covid19
06/24
11/24
NCT06389487: A Study on the Immune Response and Safety of Vaccine Against Respiratory Syncytial Virus (RSV) Given to Adults 18 to 49 Years of Age at Increased Risk for Respiratory Syncytial Virus Disease, Compared to Older Adults 60 Years of Age and Above

Active, not recruiting
3
1457
Europe, Canada, Japan, US, RoW
RSVPreF3 OA investigational vaccine
GlaxoSmithKline
Respiratory Syncytial Virus Infections
07/24
04/25
TETON, NCT04708782: Study of Efficacy and Safety of Inhaled Treprostinil in Subjects With Idiopathic Pulmonary Fibrosis

Hourglass May 2024 - Aug 2024 : Topline data for IPF
Hourglass Jan 2023 - Mar 2023 : Enrollment completion of TETON trial for IPF
Recruiting
3
576
Canada, US
Placebo, Inhaled Treprostinil, Tyvaso, Treprostinil Ultrasonic Nebulizer
United Therapeutics
Idiopathic Pulmonary Fibrosis, Interstitial Lung Disease
06/25
06/25
TETON-PPF, NCT05943535: Study of the Efficacy and Safety of Inhaled Treprostinil in Subjects With Progressive Pulmonary Fibrosis

Recruiting
3
698
Canada, US, RoW
Placebo, Inhaled Treprostinil, Tyvaso, Treprostinil Ultrasonic Nebulizer
United Therapeutics
Progressive Pulmonary Fibrosis, Interstitial Lung Disease
11/27
11/27
NECTAR, NCT04924660: Novel Experimental COVID-19 Therapies Affecting Host Response

Completed
2/3
871
US
TXA127, TRV027, Placebo, Fostamatinib
Sean Collins, National Institutes of Health (NIH), National Heart, Lung, and Blood Institute (NHLBI)
COVID-19, SARS-CoV-2 Infection, Coronavirus Infection
10/23
12/23
DAR-UM-2, NCT05987332: IDE196 (Darovasertib) in Combination With Crizotinib as First-line Therapy in Metastatic Uveal Melanoma

Recruiting
2/3
420
Europe, Canada, US, RoW
IDE196, Darovasertib, Crizotinib, XALKORI, Pembrolizumab, Keytruda, Ipilimumab, Yervoy, Nivolumab, Opdivo, Dacarbazine, DTIC-Dome
IDEAYA Biosciences
Metastatic Uveal Melanoma
01/27
01/28
NCT05212818 / 2021-000748-24: Evaluate the Efficacy and Safety of TF0023 in Treatments for COVID-19 in Hospitalized Adults

Terminated
2
19
US, RoW
TF0023, IP, Active drug
Techfields Inc
COVID-19 Pneumonia
02/23
03/23
NCT05130970 / 2021-003162-12: Garadacimab Safety, Pharmacokinetics, and Pharmacodynamics in Idiopathic Pulmonary Fibrosis

Completed
2
81
Europe, Canada, US, RoW
Garadacimab, Factor XIIa antagonist monoclonal antibody, CSL312, Placebo
CSL Behring
Idiopathic Pulmonary Fibrosis
01/24
01/24
IPF COMFORT, NCT05185089 / 2021-006278-22: Efficacy and Safety Study of Orvepitant for Chronic Cough in Patients With Idiopathic Pulmonary Fibrosis

Completed
2
80
Europe, US
Orvepitant Maleate, Placebo
Nerre Therapeutics Ltd., Pharm-Olam International
Cough, Idiopathic Pulmonary Fibrosis
06/24
06/24
RECOVER-VITAL, NCT05595369: Platform Protocol to Measure the Effects of Antiviral Therapies on Long COVID Symptoms

Active, not recruiting
2
964
US
Experimental: Paxlovid 25 day dosing, Experimental: Paxlovid 15 day dosing, Placebo Comparator: Control
Kanecia Obie Zimmerman
Long COVID, Long Covid19
08/24
03/25
NCT06404086: RECOVER-SLEEP: Platform Protocol

Recruiting
2
1074
US
Modafinil, Modafinil Placebo, Solriamfetol, Solriamfetol Placebo, Melatonin, Melantonin Placebo, Tailored lighting (TL) Active, Tailored lighting (TL) Placebo
Duke University
Long COVID, Long COVID-19, Hypersomnia, Sleep Disturbance
07/25
07/25
NCT05584670 / 2022-001239-95: A First-in-human, Dose Escalation and Dose Expansion Study of SAR445877 in Adult Participants With Advanced Solid Tumors

Recruiting
1/2
285
Europe, US, RoW
SAR445877, Cetuximab, Erbitux
Sanofi, Sanofi Aventis Recherche & Développement
Solid Tumor
01/27
09/28
NCT03786926: Trial to Evaluate the Safety and Pharmacokinetics of HMPL-689 in Patients With Lymphomas

Active, not recruiting
1
53
Europe, US
HMPL-689
Hutchmed
Lymphoma
07/24
12/24
NCT04777994: A Phase 1 Study With ABBV-CLS-484 in Subjects With Locally Advanced or Metastatic Tumors

Recruiting
1
248
Europe, Japan, US, RoW
ABBV-CLS-484, Programmed Cell Death-1 (PD-1) Inhibitor, Vascular Endothelial Growth Factor Receptor (VEGFR) Tyrosine Kinase Inhibitor (TKI)
AbbVie, Calico Life Sciences LLC
Advanced Solid Tumor Cancer
08/25
10/26
BND-35-001, NCT06274437: A Study of BND-35 in Participants With Advanced Solid Tumors

Recruiting
1
280
RoW
BND-35, Monoclonal antibody, Nivolumab, Opdivo, Cetuximab, Erbitux
Biond Biologics
Cancer
09/27
11/27
KEYNOTE-E92, NCT05378425: A Study of NTX-1088, a Monoclonal Antibody Targeting the Poliovirus Receptor (PVR, CD155), as Monotherapy and Combined With Pembrolizumab

Recruiting
1
90
US, RoW
NTX-1088, Pembrolizumab, KEYTRUDA®
Nectin Therapeutics Ltd, Merck Sharp & Dohme LLC
Cancer, Tumor, Solid, Advanced Solid Tumor, Metastatic Cancer, Locally Advanced Solid Tumor
06/25
12/25
NCT06404047: RECOVER-ENERGIZE Platform Protocol

Recruiting
N/A
660
US
Personalized Cardiopulmonary Rehabilitation, Structured Pacing, Education, Usual Care
Duke University, National Heart, Lung, and Blood Institute (NHLBI)
Long COVID, Long Covid19, Long Covid-19
10/25
01/26
PROPHETIC, NCT04056247: Predicting Responsiveness in Oncology Patients Based on Host Response Evaluation During Anti Cancer Treatments

Recruiting
N/A
2000
Europe, US, RoW
Plasma sample collection
OncoHost Ltd.
Stage IV Non-small Cell Lung Cancer, Stage IV Malignant Melanoma, Stage IV Small Cell Lung Cancer, Stage III Malignant Melanoma
10/29
10/29
Raman, Subha
NCT03490812: Assessment of Investigational Positron Emission Tomography and Post-Processing Procedures Performed as Add-ons to Standard of Care Imaging

Active, not recruiting
N/A
131
US
PET scan, Retrospective data analysis
University of Cincinnati
PET Imaging
12/24
12/24
NCT03490656: Assessment of Investigational Magnetic Resonance Imaging and Post-Processing Procedures

Active, not recruiting
N/A
77
US
MRI Scan - in addition to standard of care, MRI Scan - not in addition to standard of care
University of Cincinnati
MRI Imaging
12/24
12/24
Grobman, William
ASPIRIN, NCT06468202: Effectiveness of Two Aspirin Doses for Prevention of Hypertensive Disorders of Pregnancy: TRIAL

Recruiting
4
10742
US
Aspirin 81 mg, Aspirin 162 mg
Ohio State University, Patient-Centered Outcomes Research Institute, Northwestern University, Preeclampsia Foundation
Hypertensive Disorders of Pregnancy, Preeclampsia, Gestational Hypertension
01/29
02/30
SELECTION, NCT05838313: Should I Have an Elective Induction?

Completed
N/A
66
US
Elective Induction of Labor Decision Support Tool
University of South Florida, Ohio State University, University of California, San Francisco, Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Labor, Induced, Patient Preference
08/23
09/23
 

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