| Wierman, Margaret E |
| Recruiting | 4 | 57 | US | GnRH antagonist, Degarelix Acetate, Estrogen Product, Estrogen transdermal patch, Placebo estradiol, Placebo transdermal patch, Placebo GnRH antagonist, Placebo injection | University of Colorado, Denver, National Institute on Aging (NIA) | Menopause, Obesity, Abdominal, Aging, Weight Gain | 08/24 | 08/24 | | |
| Bowlus, Christopher L |
| Active, not recruiting | 3 | 238 | Europe, Canada, Japan, US, RoW | Linerixibat, Placebo | GlaxoSmithKline | Pruritus | 10/24 | 01/25 | | |
| Recruiting | 3 | 251 | Europe, Canada, Japan, US, RoW | Linerixibat | GlaxoSmithKline, GlaxoSmithKline LLC, GlaxoSmithKline Research & Development Limited | Cholestasis | 02/27 | 02/27 | | |
| Recruiting | 2 | 42 | US | Sulfasalazine, Azulfidine, Placebo | Brigham and Women's Hospital | Primary Sclerosing Cholangitis | 09/24 | 11/24 | | |
| Active, not recruiting | 2 | 60 | US | Bezafibrate 100 mg, Bezafibrate 200 mg, Obeticholic Acid 5 mg, Obeticholic Acid placebo, Bezafibrate Placebo | Intercept Pharmaceuticals, Intercept Pharmaceuticals, Inc. | Primary Biliary Cholangitis | 11/24 | 02/25 | | |
| Active, not recruiting | 2 | 68 | Europe, US, RoW | Anti-human CCL24 monoclonal antibody (CM-101), Placebo | ChemomAb Ltd., ChemomAb Ltd | Primary Sclerosing Cholangitis | 09/24 | 09/25 | | |
VISTAS, NCT04663308 / 2020-003027-41: A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Sclerosing Cholangitis (PSC) |
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| Recruiting | 2 | 200 | Europe, Canada, US, RoW | Volixibat, SHP626, Placebo | Mirum Pharmaceuticals, Inc., Mirum Pharmaceuticals, Inc. | Primary Sclerosing Cholangitis | 09/25 | 12/25 | | |
NCT06699121: A Study to Assess the Safety and Efficacy of LB-P8 in Patients With PSC |
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| Not yet recruiting | 2 | 87 | US | LB-P8 low-dose, LB-P8 high-dose, Placebo | LISCure Biosciences | Primary Sclerosing Cholangitis (PSC) | 03/28 | 02/29 | | |
NCT04505436: Study to Evaluate Efficacy, Safety and Tolerability of HM15211 in Subjects |
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| Recruiting | 2 | 240 | US, RoW | HM15211, Placebo of HM15211 | Hanmi Pharmaceutical Company Limited | NASH - Nonalcoholic Steatohepatitis | 05/26 | 11/26 | | |
| Active, not recruiting | 2 | 271 | Europe, Canada, Japan, US, RoW | GSK4532990, Placebo | GlaxoSmithKline, GlaxoSmithKline Research & Development Limited | Nonalcoholic Fatty Liver Disease, Non-alcoholic Fatty Liver Disease | 12/25 | 03/26 | | |
NCT05104853: Study to Evaluate the Safety, Tolerability, PDs, and Efficacy of CNP-104 in Subjects with Primary Biliary Cholangitis |
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| Active, not recruiting | 1/2 | 42 | US | CNP-104, Placebo | COUR Pharmaceutical Development Company, Inc. | Primary Biliary Cholangitis | 01/26 | 01/26 | | |
| Wagh, Mihir |
| Active, not recruiting | N/A | 1000 | US | AGBS, Allurion Gastric Balloon System (AGBS) | Allurion Technologies | Obesity | 11/24 | 03/25 | | |
NCT04404101: Evaluation of Pancreatic Cystic Lesions Via EUS-guided Fine Needle Aspiration With and Without Micro Forceps Biopsies |
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| Recruiting | N/A | 300 | US | 1). EUS-FNA plus MFB, 2). EUS-FNA Alone | University of Colorado, Denver, US Endoscopy | Pancreatic Cyst | 04/25 | 04/25 | | |
NCT03626194: Prospective Evaluation of the Efficacy and Safety of Endoscopic Tissue Apposition |
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| Recruiting | N/A | 500 | US | | University of Colorado, Denver | Endoscopic Tissue Apposition, Endoscopic Suturing, Endoscopic Clipping, Bariatric Endoscopy, Transoral Outlet Reduction, Endoscopic Sleeve Gastroplasty | 12/25 | 12/26 | | |
SWAT-BE, NCT05530343: Seattle Biopsy Protocol Versus Wide-Area Transepithelial Sampling in Patients With Barrett's Esophagus Undergoing Surveillance |
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| Recruiting | N/A | 2298 | US | Seattle protocol, WATS3D brushings | University of Colorado, Denver | Barrett Esophagus, Barretts Esophagus With Dysplasia, Esophageal Adenocarcinoma | 03/26 | 03/26 | | |
| Mark, Tomer |
| Recruiting | 1 | 35 | US | Venetoclax, ABT-199, Abbvie, CC-486 | University of Colorado, Denver, Bristol-Myers Squibb | AML | 03/27 | 03/29 | | |
| Terminated | N/A | 465 | US | clonoSEQ Assay | Adaptive Biotechnologies | Acute Lymphoblastic Leukemia, Adult B-Cell, Chronic Lymphocytic Leukemia, Multiple Myeloma, Non-hodgkin Lymphoma | 10/23 | 10/23 | | |
| Cho, Steve |
CLARIFY, NCT06056830: Positron Emission Tomography Using 64Cu-SAR-bisPSMA in Participants With High-risk Prostate Cancer Prior to Radical Prostatectomy |
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| Recruiting | 3 | 383 | US, RoW | 64Cu-SAR-bisPSMA | Clarity Pharmaceuticals Ltd | Prostate Cancer, Prostatic Neoplasms | 02/25 | 02/25 | | |
| Terminated | 2 | 15 | US | PSMA-based 18F-DCFPyL PET tracer, PSMA | University of Wisconsin, Madison | Gynecologic Cancer | 01/20 | 01/20 | | |
NCT04573231: Evaluation of PSMA in HER2- AR+ Metastatic Breast Cancer |
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| Recruiting | 2 | 13 | US | 18F-DCFPyL | University of Wisconsin, Madison | Breast Cancer, HER2-negative Breast Cancer, Metastatic Breast Cancer | 11/25 | 11/25 | | |
NCT05293626: Gene Therapy Clinical Trial for the Treatment of Leber's Hereditary Optic Neuropathy Associated With ND4 Mutations |
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| Active, not recruiting | 1/2 | 12 | US | NR082 Injection, Injection needle, Syringe | Neurophth Therapeutics Inc | Leber Hereditary Optic Neuropathy (LHON) | 07/25 | 12/29 | | |
NCT03232164: PSMA-based 18F-DCFPyL PET/CT and PET/MRI Pilot Studies in Prostate Cancer |
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| Completed | 1 | 126 | US | 18F-DCFPyL PET | University of Wisconsin, Madison | Prostate Cancer, Prostate Neoplasm | 11/24 | 11/24 | | |
NCT06122610: Using Novel Imaging to More Safely Treat Neuroendocrine Tumors |
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| Recruiting | 1 | 10 | US | Single Photon Emission Computed Tomography/ Computed Tomography (SPECT/CT), Photon Emission Tomography / CT (PET/CT), 64Cu-Dotatate, Detectnet, 177Lu-Dotatate, Lutathera® | University of Wisconsin, Madison | Neuroendocrine Tumors, Somatostatin Receptor-positive Neuroendocrine Tumor | 04/25 | 04/25 | | |
NCT06199713: Correlating Early FDG PET/CT and ctDNA in Immune Checkpoint Inhibitor (ICI)-Treated Melanoma Patients |
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| Recruiting | N/A | 24 | US | 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography, 18F-FDG PET/CT | University of Wisconsin, Madison | Melanoma, Melanoma Stage III, Melanoma Stage IV, Unresectable Melanoma | 01/26 | 01/29 | | |
VENICE, NCT05280366: STREAMLINE®SURGICAL SYSTEM Compared to iStent Inject W® in Patients With Open-Angle Glaucoma |
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| Active, not recruiting | N/A | 150 | US, RoW | Streamline Surgical System, iStent Inject W | New World Medical, Inc. | Open Angle Glaucoma | 06/26 | 06/26 | | |
| Nowak, Kristen L Jablonski |
NCT04534985: Time Restricted Feeding in Autosomal Dominant Polycystic Kidney Disease |
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| Completed | N/A | 29 | US | Dietary | University of Colorado, Denver, PKD Foundation | Polycystic Kidney, Autosomal Dominant | 03/23 | 03/23 | | |
| Recruiting | N/A | 126 | US | Daily caloric restriction, Standard advice control | University of Colorado, Denver, Mayo Clinic, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Autosomal Dominant Polycystic Kidney, Overweight and Obesity | 07/26 | 07/26 | | |
NCT04911491: Inspiratory Muscle Strength Training in Chronic Kidney Disease |
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| Recruiting | N/A | 108 | US | IMST, Sham Training | University of Colorado, Denver, University of Colorado, Boulder, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Chronic Kidney Diseases, Hypertension, Aging, Blood Pressure | 07/26 | 07/26 | | |
| Lee, Joyce |
| Active, not recruiting | 3 | 202 | US | N-acetyl cysteine, NAC, Placebo | Weill Medical College of Cornell University, University of Virginia, University of Michigan, Pulmonary Fibrosis Foundation, University of Washington, National Heart, Lung, and Blood Institute (NHLBI), Three Lakes Foundation | Idiopathic Pulmonary Fibrosis | 02/26 | 02/26 | | |
BLISSc-ILD, NCT05878717: A Study of the Efficacy and Safety of Belimumab in Adults With Systemic Sclerosis Associated Interstitial Lung Disease |
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| Recruiting | 2/3 | 300 | Europe, Japan, US, RoW | Belimumab, BENLYSTA™, GSK1550188, LymphoStat-B™, BENLYSTATM, GSK1550188, LymphoStat-B™, Placebo | GlaxoSmithKline | Systemic Sclerosis Associated Interstitial Lung Disease, Scleroderma, Systemic | 07/27 | 07/27 | | |
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NCT05671835: Study of TTI-101 in Participants With Idiopathic Pulmonary Fibrosis |
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| Recruiting | 2 | 75 | US | TTI-101, Placebo | Tvardi Therapeutics, Incorporated | Idiopathic Pulmonary Fibrosis | 03/25 | 07/25 | | |
MOUNTAIN, NCT06397677: Defining the Molecular and Radiologic Phenotype of Progressive RA Interstitial Lung Disease |
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| Recruiting | N/A | 450 | US | Research Testing Performed (Laboratory), Information Collected as Standard of Care, Research Testing Performed | University of Colorado, Denver, National Heart, Lung, and Blood Institute (NHLBI), University of California, San Francisco, University of Michigan, University of Kansas | Rheumatoid Arthritis, Interstitial Lung Disease | 01/29 | 01/34 | | |
| Recruiting | N/A | 750 | US | | University of Colorado, Denver | Rheumatoid Arthritis, Interstitial Lung Disease | 06/27 | 06/27 | | |
| Chonchol, Michel B |
NCT03273413: Statin Therapy in Patients With Early Stage ADPKD |
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| Active, not recruiting | 4 | 150 | US | Pravastatin, Placebo | University of Colorado, Denver | ADPKD, Autosomal Dominant Polycystic Kidney | 03/24 | 04/24 | | |
NCT04040959: Nicotinamide Riboside Supplementation for Treating Arterial Stiffness and Elevated Systolic Blood Pressure in Patients With Moderate to Severe CKD |
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| Recruiting | 2 | 118 | US | Nicotinamide riboside | University of Colorado, Denver, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Vascular Diseases, Kidney Disease, Blood Pressure, Oxidative Stress | 05/24 | 09/24 | | |
NCT05510115: Feasibility of Study of Empagliflozin in Patients With Autosomal Dominant Polycystic Kidney Disease |
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| Recruiting | 2 | 50 | US | Empagliflozin, Placebo | University of Colorado, Denver, University of Maryland | Polycystic Kidney, Autosomal Dominant | 03/26 | 03/26 | | |
| Completed | N/A | 139 | US | Active Comparator: peer navigator, Placebo Comparator: Control Arm (standard of care) | University of Colorado, Denver, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Racial/Ethnic Minorities on Dialysis | 07/24 | 07/24 | | |
NCT04911491: Inspiratory Muscle Strength Training in Chronic Kidney Disease |
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| Recruiting | N/A | 108 | US | IMST, Sham Training | University of Colorado, Denver, University of Colorado, Boulder, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Chronic Kidney Diseases, Hypertension, Aging, Blood Pressure | 07/26 | 07/26 | | |
| Taylor, Matthew |
| Active, not recruiting | 2 | 194 | Europe, US, RoW | ISA101b, Cemiplimab, Placebo | ISA Pharmaceuticals, Regeneron Pharmaceuticals | Squamous Cell Carcinoma of the Oropharynx, HPV16 Positive | 09/24 | 06/25 | | |
NCT05308901: Lenvatinib Plus Pembrolizumab In Patients With Immune Checkpoint Inhibitor Naïve Metastatic Uveal Melanoma |
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| Active, not recruiting | 2 | 6 | US | Pembrolizumab, Keytruda, Lenvatinib | Providence Health & Services, Merck Sharp & Dohme LLC, Eisai Inc. | Melanoma, Uveal | 12/24 | 06/27 | | |
CA209-73R, NCT04061980: Encorafenib and Binimetinib With or Without Nivolumab in Treating Patients With Metastatic Radioiodine Refractory BRAF V600 Mutant Thyroid Cancer |
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| Active, not recruiting | 2 | 24 | US | Binimetinib, ARRY-162, ARRY-438162, MEK162, Mektovi, Encorafenib, Braftovi, LGX 818, LGX-818, LGX818, Nivolumab, BMS-936558, MDX-1106, NIVO, ONO-4538, Opdivo | Providence Health & Services, Providence Cancer Center, Earle A. Chiles Research Institute | BRAF NP_004324.2:p.V600M, BRAF V600E Mutation Present, Metastatic Thyroid Gland Carcinoma, Refractory Thyroid Gland Carcinoma, Stage IV Differentiated Thyroid Gland Carcinoma AJCC v8, Stage IVA Differentiated Thyroid Gland Carcinoma AJCC v8, Stage IVB Differentiated Thyroid Gland Carcinoma AJCC v8 | 10/25 | 10/27 | | |
NCT04938609: Neoadjuvant Immunoradiotherapy in Head & Neck Cancer (NIRT 2-HNC) |
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| Recruiting | 2 | 28 | US | Pembrolizumab, Keytruda, Stereotactic Body Radiation Therapy (5 days), Surgical Resection | Providence Health & Services, Providence Cancer Center, Earle A. Chiles Research Institute | Head and Neck Cancer, Head and Neck Squamous Cell Carcinoma | 01/27 | 01/31 | | |
NCT05200143: Study of Ipilimumab, Nivolumab, and Cabozantinib in Patients With Cutaneous Melanoma |
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| Terminated | 2 | 4 | US | Ipilimumab, Nivolumab, BMS-936558, MDX1106, ONO-4538, Cabozantinib, XL184 | Providence Health & Services, Bristol-Myers Squibb, Exelixis | Refractory Cutaneous Melanoma | 09/23 | 07/24 | | |
NCT05913388: GB1211 and Pembrolizumab Versus Pembrolizumab and Placebo in Patients With Metastatic Melanoma and Head and Neck Squamous Cell Carcinoma |
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| Recruiting | 2 | 92 | US | GB1211, Pembrolizumab, Keytruda, Placebo | Providence Health & Services, Providence Cancer Center, Providence Cancer Center, Earle A. Chiles Research Institute, Galecto Biotech AB | Metastatic Melanoma, Head and Neck Squamous Cell Carcinoma | 02/28 | 02/30 | | |
| Recruiting | 1/2 | 320 | US, RoW | BA3071, Nivolumab, Pembrolizumab, Pemetrexed (Alimta) | BioAtla, Inc. | NSCLC, Melanoma | 12/25 | 06/26 | | |
| Recruiting | 1/2 | 316 | US | ST-067, Obinutuzumab 25 MG/1 ML Intravenous Solution [GAZYVA], GAZYVA, pembrolizumab, KEYTRUDA® | Simcha IL-18, Inc., Merck Sharp & Dohme LLC | Cancer, Solid Tumor, Melanoma, Renal Cell Carcinoma, Triple-negative Breast Cancer, Non Small Cell Lung Cancer, Squamous Cell Carcinoma of the Head and Neck, Carcinoma, MSI-High | 06/25 | 12/25 | | |
| Recruiting | 1/2 | 265 | Europe, US, RoW | EP0031 | Ellipses Pharma | Advanced Solid Tumor | 12/26 | 06/27 | | |
IO-108-CL-001, NCT05054348: First-in-human Study of IO-108 as Single Agent and in Combination With a PD-1 Immune Check Point Inhibitor in Patients With Advanced Solid Tumors |
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| Completed | 1 | 91 | US | IO-108, IO-108 + pembrolizumab combination therapy, IO-108 + Keytruda combination therapy, IO-108 + cemiplimab combination therapy, IO-108 + Libtayo combination therapy | Immune-Onc Therapeutics, Regeneron Pharmaceuticals | Solid Tumor, Adult | 04/24 | 05/24 | | |
NCT01107522: Safety and Tolerability of Carboxyamidotriazole Orotate (CTO) in Solid Tumors or With Temodar® in Glioblastoma or Other Recurrent Malignant Gliomas or in Combination With Temodar® and Radiation Therapy for Patients With Newly Diagnosed Glioblastoma and Malignant Gliomas |
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| Active, not recruiting | 1 | 100 | US | CTO, CTO and Temodar®, CTO, Temodar®, Radiation therapy | Tactical Therapeutics, Inc. | Solid Tumors, Glioblastoma, Recurrent Malignant Gliomas | 01/25 | 01/26 | | |
RIDGE-1, NCT06228924: Open-label, Dose Escalation Study of Safety and Preliminary Efficacy of TN-401 in Adults with PKP2 Mutation-associated ARVC |
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| Recruiting | 1 | 15 | US | TN-401 | Tenaya Therapeutics, Johns Hopkins University, Mayo Clinic | Arrhythmogenic Right Ventricular Cardiomyopathy | 05/26 | 10/29 | | |
| Recruiting | 1 | 60 | Canada, US | TBio-4101, TIL, autologous, tumor-reactive, T-cell product, Pembrolizumab, Keytruda | Turnstone Biologics, Corp. | Breast Cancer, Colorectal Cancer, Uveal Melanoma, Cutaneous Melanoma, Non-Small Cell Lung Cancer, Head and Neck Squamous Cell Carcinoma | 12/24 | 06/25 | | |
NCT03882437: Gene Therapy for Male Patients With Danon Disease (DD) Using RP-A501; AAV9.LAMP2B |
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| Active, not recruiting | 1 | 7 | US | RP-A501 | Rocket Pharmaceuticals Inc. | Danon Disease | 03/25 | 03/25 | | |
| Completed | 1 | 91 | US | AGEN2373, Anti-CD137, Botensilimab, AGEN1181, Anti-CTLA-4 | Agenus Inc. | Advanced Cancer | 02/24 | 11/24 | | |
RIDGE, NCT06311708: Non-interventional Study of Seroprevalence of Pre-existing Antibodies Against Adenovirus-associated Virus Vector (AAV9) and the Progression of Disease in Patients With Plakophilin 2 (PKP2)-Associated Arrhythmogenic Right Ventricular Cardiomyopathy (ARVC) |
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| Recruiting | N/A | 200 | Europe, US | | Tenaya Therapeutics, University of California, San Francisco, Brigham and Women's Hospital, New York University, University of Colorado, Denver, Johns Hopkins University, The Cleveland Clinic, Mayo Clinic, Medical University of South Carolina, Hopital Louis Pradel, Istituti Clinici Scientifici Maugeri SpA, The Queen Elizabeth Hospital, St George's University Hospitals NHS Foundation Trust, Royal Brompton & Harefield NHS Foundation Trust, Barts & The London NHS Trust, Skane University Hospital, Centro Cardiologico Monzino, Hôpital Haut-Lévêque, Nantes University Hospital, Pitié-Salpêtrière Hospital, Wuerzburg University Hospital, University Hospital Muenster | Arrhythmogenic Right Ventricular Cardiomyopathy | 03/30 | 07/30 | | |
NCT05389514: Intermediate-size IND for Treatment of KRAS G12V-mutant Tumors |
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| Temporarily Not Available | N/A | | NA | Cyclophosphamide, Cytoxan, Cytoxan Lyophilized, Cy, Gemcitabine, Gemzar, Pembrolizumab, KEYTRUDA, MK-3475, Cell Infusion | Providence Health & Services | KRAS G12V Mutant Advanced Epithelial Cancers | | | | |
| Recruiting | N/A | 46 | Europe, US, RoW | No intervention | Rocket Pharmaceuticals Inc. | Danon Disease | 08/26 | 08/26 | | |
| Recruiting | N/A | 30 | US | Transcutaneous auricular vagus nerve stimulation, Roscoe TENS 7000, Sham device | Northwell Health, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Nephrotic Syndrome in Children, Minimal Change Disease, Focal Segmental Glomerulosclerosis | 08/25 | 08/25 | | |
| Completed | N/A | 20 | US | Creatine Monohydrate | University of Kansas Medical Center, Alzheimer's Association | Alzheimer's Disease | 05/24 | 05/24 | | |
| Recruiting | N/A | 10 | US | trascutaneous auricular vagus nerve stimulation, Roscoe TENS 7000, Sham device | Northwell Health, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Nephrotic Syndrome in Children, Minimal Change Disease, Focal Segmental Glomerulosclerosis | 04/25 | 08/25 | | |
| Bessesen, Daniel H |
| Recruiting | 4 | 57 | US | GnRH antagonist, Degarelix Acetate, Estrogen Product, Estrogen transdermal patch, Placebo estradiol, Placebo transdermal patch, Placebo GnRH antagonist, Placebo injection | University of Colorado, Denver, National Institute on Aging (NIA) | Menopause, Obesity, Abdominal, Aging, Weight Gain | 08/24 | 08/24 | | |
| Active, not recruiting | 3 | 2300 | Europe, Canada, US, RoW | Retatrutide, LY3437943, Placebo | Eli Lilly and Company | Obesity, Overweight, Osteoarthritis, Knee, Obstructive Sleep Apnea | 04/26 | 05/26 | | |
| Recruiting | N/A | 75 | US | Weight Loss, Exercise training, Overfeeding | University of Colorado, Denver, University of Colorado, Boulder | Obesity | 01/24 | 01/24 | | |
| Kaufman, Carol E |
| Completed | N/A | 439 | US | Native WYSE CHOICES | University of Colorado, Denver, National Institute on Alcohol Abuse and Alcoholism (NIAAA) | Alcohol Exposed Pregnancy | 02/24 | 02/24 | | |
| Davis, Shanlee M |
NCT05498090: Interrogating Fatty Acid Metabolism Impairment and Clinical Correlates in Males with Klinefelter Syndrome |
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| Active, not recruiting | 4 | 44 | US | Fenofibrate 145 mg | University of Colorado, Denver, National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Klinefelter Syndrome | 06/25 | 08/25 | | |
NCT06668805: A Phase 2 Basket Study of Vosoritide in Children with Turner Syndrome, SHOX Deficiency and Noonan Syndrome with an Inadequate Response to Human Growth Hormone |
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| Recruiting | 2 | 72 | US | Vosoritide Injection, Human Growth Hormone | BioMarin Pharmaceutical | Short Stature Homeobox- Containing Gene SHOX Deficiency, Noonan Syndrome, Turner Syndrome | 03/27 | 09/41 | | |
| Recruiting | N/A | 5000 | US | no intervention | University of Colorado, Denver, Children's Hospital Colorado | Sex Chromosome Aneuploidy | 04/37 | 04/37 | | |
NCT03396562: The eXtroardinarY Babies Study: Natural History of Health and Neurodevelopment in Infants and Young Children With Sex Chromosome Trisomy |
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| Recruiting | N/A | 300 | US | Assessments of Development and Growth | University of Colorado, Denver | Klinefelter Syndrome, Trisomy X, XYY Syndrome, XXXY and XXXXY Syndrome, Xxyy Syndrome, Xyyy Syndrome, Xxxx Syndrome, Xxxxx Syndrome, Xxxyy Syndrome, Xxyyy Syndrome, Xyyyy Syndrome, Male With Sex Chromosome Mosaicism | 03/28 | 03/28 | | |
| Recruiting | N/A | 5000 | US | No intervention | University of Colorado, Denver | Turner Syndrome | 10/25 | 10/25 | | |
| Webel, Allison R |
| Recruiting | N/A | 850 | US | No intervention | University of Washington, University of Alabama at Birmingham, National Institute of Nursing Research (NINR) | HIV/AIDS | 04/23 | 04/23 | | |
REST, NCT04946994: Relationship of Exercise, Sleep, and Inflammation Markers in People Living with HIV |
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| Recruiting | N/A | 50 | US | HIIT, CME | Christine Horvat Davey, University of Washington, University of Colorado - Anschutz Medical Campus | Hiv, Sleep | 05/25 | 05/25 | | |
NCT04550676: High-Intensity Exercise to Attenuate Limitations and Train Habits in Older Adults With HIV |
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| Active, not recruiting | N/A | 118 | US | HIIT (intervention), CME (active control) | University of Colorado, Denver, Case Western Reserve University, University of Washington | Hiv, Fatigue, Mobility Limitation | 07/25 | 12/25 | | |
HEALTH-COG, NCT06013579: Effect of High-Intensity Exercise to Attenuate Cognitive Function Limitations and Train Exercise Habits in Older People Living With HIV |
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| Recruiting | N/A | 110 | US | Phase 1 Gym Exercise HIIT, Phase 1 Gym Exercise CME, Phase 2 Home Exercise Coaching Text Messages, Phase 2 Home Exercise Control Text Messages | University of Alabama at Birmingham, University of Colorado, Denver, University of Washington, National Institute on Aging (NIA) | HIV Infections, Cognitive Impairment | 09/27 | 03/28 | | |
| Deane, Kevin |
| Recruiting | N/A | 750 | US | | University of Colorado, Denver | Rheumatoid Arthritis, Interstitial Lung Disease | 06/27 | 06/27 | | |
| Erlandson, Kristine |
| Completed | 3 | 602 | US | Pitavastatin, Placebos | Advancing Clinical Therapeutics Globally for HIV/AIDS and Other Infections, National Institute of Allergy and Infectious Diseases (NIAID), National Institute on Aging (NIA) | HIV-1 Infection | 08/23 | 08/23 | | |
NCT04216589: Study of Semaglutide for Non-Alcoholic Fatty Liver Disease (NAFLD), a Metabolic Syndrome With Insulin Resistance, Increased Hepatic Lipids, and Increased Cardiovascular Disease Risk (The SLIM LIVER Study) |
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| Completed | 2 | 51 | US, RoW | Semaglutide | National Institute of Allergy and Infectious Diseases (NIAID), The University of Texas Health Science Center, Houston | HIV Infections, Non-Alcoholic Fatty Liver Disease | 03/23 | 09/23 | | |
| Active, not recruiting | 2 | 51 | US, RoW | Semaglutide | AIDS Clinical Trials Group, National Institute of Allergy and Infectious Diseases (NIAID) | HIV-1-infection, Adiposity, Insulin Resistance, Pre-diabetes, Hepatic Steatosis | 08/23 | 08/23 | | |
| Recruiting | 2 | 380 | US | IVIG + Coordinated Care, IVIG Placebo + Coordinated Care, Ivabradine + Coordinated Care, Ivabradine Placebo + Coordinated Care, IVIG + Usual Care, IVIG Placebo + Usual Care, Ivabradine + Usual Care, Ivabradine Placebo + Usual Care | Kanecia Obie Zimmerman | Long COVID, Long Covid19, Long Covid-19 | 12/25 | 03/26 | | |
| Recruiting | 2 | 1074 | US | Modafinil, Modafinil Placebo, Solriamfetol, Solriamfetol Placebo, Melatonin, Melantonin Placebo, Tailored lighting (TL) Active, Tailored lighting (TL) Placebo | Duke University | Long COVID, Long COVID-19, Hypersomnia, Sleep Disturbance | 07/25 | 07/25 | | |
| Not yet recruiting | 2 | 100 | US | Tesamorelin, Egrifta, TH9507, growth hormone-releasing hormone analogue, Placebo, Exercise | Massachusetts General Hospital, University of Colorado - Anschutz Medical Campus | HIV-1-infection, Frailty, Impaired Physical Function, Abdominal Obesity, Aging | 03/28 | 09/28 | | |
NCT04495348: Explorations Into the Mechanism for INSTI-associated Weight Gain: a Focus on Energy Balance |
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| Completed | N/A | 18 | US | Doravirine | University of Colorado, Denver, Gilead Sciences | HIV-1-infection, Weight Gain | 01/23 | 06/23 | | |
NCT05172024: Understanding the Long-term Impact of COVID-19 in Adults (RECOVER) |
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| Active, not recruiting | N/A | 15178 | US | | NYU Langone Health, National Heart, Lung, and Blood Institute (NHLBI) | SARS-CoV2 Infection | 04/25 | 05/25 | | |
NCT04550676: High-Intensity Exercise to Attenuate Limitations and Train Habits in Older Adults With HIV |
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| Active, not recruiting | N/A | 118 | US | HIIT (intervention), CME (active control) | University of Colorado, Denver, Case Western Reserve University, University of Washington | Hiv, Fatigue, Mobility Limitation | 07/25 | 12/25 | | |
HEALTH-COG, NCT06013579: Effect of High-Intensity Exercise to Attenuate Cognitive Function Limitations and Train Exercise Habits in Older People Living With HIV |
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| Recruiting | N/A | 110 | US | Phase 1 Gym Exercise HIIT, Phase 1 Gym Exercise CME, Phase 2 Home Exercise Coaching Text Messages, Phase 2 Home Exercise Control Text Messages | University of Alabama at Birmingham, University of Colorado, Denver, University of Washington, National Institute on Aging (NIA) | HIV Infections, Cognitive Impairment | 09/27 | 03/28 | | |
| Forman, Lisa |
NCT01846663: Efficacy, Safety, And Pharmacokinetics Of Rifaximin In Subjects With Severe Hepatic Impairment And Hepatic Encephalopathy |
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| Terminated | 4 | 6 | US | Placebo, Rifaximin, XIFAXAN® Tablets | Bausch Health Americas, Inc. | Hepatic Encephalopathy | 02/16 | 02/16 | | |
VISTAS, NCT04663308 / 2020-003027-41: A Study to Evaluate Efficacy and Safety of an Investigational Drug Named Volixibat in Patients With Itching Caused by Primary Sclerosing Cholangitis (PSC) |
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| Recruiting | 2 | 200 | Europe, Canada, US, RoW | Volixibat, SHP626, Placebo | Mirum Pharmaceuticals, Inc., Mirum Pharmaceuticals, Inc. | Primary Sclerosing Cholangitis | 09/25 | 12/25 | | |
NCT05569759: A Study of Zetomipzomib (KZR-616) in Patients With Autoimmune Hepatitis (PORTOLA) |
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| Active, not recruiting | 2 | 24 | US | zetomipzomib, KZR-616, placebo, sterile water for injection, zetomipzomib in open-label extension | Kezar Life Sciences, Inc. | Autoimmune Hepatitis | 02/25 | 08/25 | | |
NCT06699121: A Study to Assess the Safety and Efficacy of LB-P8 in Patients With PSC |
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| Not yet recruiting | 2 | 87 | US | LB-P8 low-dose, LB-P8 high-dose, Placebo | LISCure Biosciences | Primary Sclerosing Cholangitis (PSC) | 03/28 | 02/29 | | |
| Moreau, Kerrie L |
| Recruiting | 4 | 100 | US | Degarelix, GnRH antagonist, Ovarian suppression, Transdermal Estradiol Patch, Transdermal Placebo Patch | University of Colorado, Denver, National Institute on Aging (NIA) | Menopause, Estrogen Deficiency, Aging, Adiposity | 05/28 | 08/28 | | |
| Recruiting | 4 | 57 | US | GnRH antagonist, Degarelix Acetate, Estrogen Product, Estrogen transdermal patch, Placebo estradiol, Placebo transdermal patch, Placebo GnRH antagonist, Placebo injection | University of Colorado, Denver, National Institute on Aging (NIA) | Menopause, Obesity, Abdominal, Aging, Weight Gain | 08/24 | 08/24 | | |
| Active, not recruiting | 1 | 22 | US | MitoQ, Mitoquinol, Placebo, Aerobic exercise | University of Colorado, Denver, National Institute on Aging (NIA) | Aging, Menopause | 09/24 | 11/24 | | |
| Completed | N/A | 232 | US | Acyline, Gonadotropin releasing hormone antagonist, Placebo Gel, Placebo, Placebo Tablet, Testosterone Gel, Transdermal Testosterone Gel, Arimidex, Aromatase inhibitor | University of Colorado, Denver, National Institute on Aging (NIA) | Hypogonadism | 01/23 | 01/23 | | |
NCT05365607: NightWare and Cardiovascular Health in Adults With PTSD |
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| Completed | N/A | 40 | US | NightWare, Sham NightWare | University of Colorado, Denver, National Institute on Aging (NIA) | Posttraumatic Stress Disorder, Cardiovascular Diseases, Autonomic Dysfunction, Vascular Stiffness, Nightmare, Endothelial Dysfunction | 08/24 | 08/24 | | |
NCT06419959: NightWare and Cardiovascular Health in Veterans With PTSD |
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| Not yet recruiting | N/A | 125 | US | NightWare | VA Office of Research and Development | Post-traumatic Stress Disorder (PTSD), Cardiovascular Diseases, Autonomic Dysfunction, Vascular Stiffness, Nightmare, Endothelial Dysfunction, Veteran | 09/26 | 09/26 | | |
| Kohrt, Wendy M |
| Recruiting | 4 | 57 | US | GnRH antagonist, Degarelix Acetate, Estrogen Product, Estrogen transdermal patch, Placebo estradiol, Placebo transdermal patch, Placebo GnRH antagonist, Placebo injection | University of Colorado, Denver, National Institute on Aging (NIA) | Menopause, Obesity, Abdominal, Aging, Weight Gain | 08/24 | 08/24 | | |
| Completed | 2 | 223 | US | Aerobic exercise, Perindopril, Losartan, HCTZ | University of Alabama at Birmingham, University of Colorado, Denver, AdventHealth Translational Research Institute | Hypertension, Aging, Sedentary Lifestyle | 09/24 | 09/24 | | |
| Active, not recruiting | 1 | 22 | US | MitoQ, Mitoquinol, Placebo, Aerobic exercise | University of Colorado, Denver, National Institute on Aging (NIA) | Aging, Menopause | 09/24 | 11/24 | | |
| Active, not recruiting | N/A | 18 | US | Endurance exercise intervention | VA Office of Research and Development | Exercise, Bone Resorption, Bone Formation | 04/25 | 12/25 | | |
| Moss, Marc |
| Not yet recruiting | 2 | 80 | US | Methylprednisolone, Normal Saline | University of Colorado, Denver, National Institute on Aging (NIA) | Dysphagia, Laryngeal Edema | 11/26 | 05/27 | | |
| Completed | N/A | 247 | US | Mobile mindfulness-based training | Duke University, University of Washington, University of Colorado, Denver, National Center for Complementary and Integrative Health (NCCIH) | Cardiorespiratory Failure | 05/23 | 07/23 | | |
| Recruiting | N/A | 4000 | US | Blood collection, Urine Collection, Nasal, oral, and rectal swabs, Stool collection, Heat Moisture Exchange Filter collection, Tracheal Aspirate sample collection, Non-bronchoscopic bronchoalveolar lavage (NBBAL), Surveys, Short physical performance battery, Hand grip strength, CNS Vital Signs, Muscle Ultrasound, Muscle Strength, Spirometry, Lung Diffusion Testing (DLCO), Chest CT Scan | Vanderbilt University Medical Center | ARDS, Sepsis, Pneumonia | 04/28 | 04/28 | | |
