| O'Toole, Robert |
TOBRA, NCT04597008: Topical Antibiotic Therapy to Reduce Infection After Operative Treatment of Fractures At High Risk of Infection: |
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| Recruiting | 3 | 1900 | US | Treatment group, Treatment, Control group, Control | Major Extremity Trauma Research Consortium, United States Department of Defense | Post Operative Surgical Site Infection | 06/25 | 12/26 | | |
NCT04678154: Evaluation of a New Strategy for Protocolized Antibiotic Care for Severe Open Fractures: SEXTANT |
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| Recruiting | 3 | 1200 | US | Standard of care, Vancomycin and Tobramycin | Major Extremity Trauma Research Consortium, United States Department of Defense | Post Operative Surgical Site Infection | 09/24 | 03/25 | | |
POvIV2, NCT05699174: PO vs IV Antibiotics for the Treatment of Infected Nonunion of Fractures After Fixation |
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| Recruiting | 3 | 250 | US | Standard of Care PO (oral) antibiotics, Standard of Care Intravenous (IV) antibiotics | Major Extremity Trauma Research Consortium, United States Department of Defense | Infections, Infected Wound, Nonunion of Fracture, Injury Leg, Amputation, Internal Fixation; Complications, Infection or Inflammation, Fracture, Lower Extremity Fracture, Antibiotic Side Effect | 09/25 | 09/26 | | |
MBTK, NCT04047030: The Mobility Toolkit: Electronically Augmented Assessment of Functional Recovery Following Lower-extremity Trauma |
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| Recruiting | N/A | 450 | US | None- Observational Study | Major Extremity Trauma Research Consortium | Gait | 12/23 | 08/24 | | |
NCT05595148: Immediate Weightbearing Vs Delayed Weightbearing |
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| Enrolling by invitation | N/A | 100 | US | Immediate WBAT, No Intervention: Delayed WBAT | University of Maryland, Baltimore | Rehabilitation | 12/25 | 12/25 | | |
NCT04028414: Effects of Early Weight Bearing on Rehabilitation Outcomes in Patients With Traumatic Ankle and Tibial Plateau Fractures |
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| Active, not recruiting | N/A | 450 | US | Early Weight Bearing | Major Extremity Trauma Research Consortium | Rehabilitation | 10/24 | 03/25 | | |
| Slobogean, Gerard |
| Completed | 4 | 8485 | Canada, US | DuraPrep, ChloraPrep | University of Maryland, Baltimore, McMaster University, Patient-Centered Outcomes Research Institute | Surgical Site Infection, Unplanned Fracture-Related Reoperation, Open Appendicular Fracture, Closed Lower Extremity Fracture, Pelvic Fracture | 03/23 | 02/24 | | |
| Recruiting | 3 | 312 | Canada, US | Antibiotic Cement Bead Pouch, Negative Pressure Wound Therapy | University of Maryland, Baltimore, McMaster University | Open Tíbia Fracture | 03/25 | 10/25 | | |
NCT04403204: ICG Fluorescence Imaging in Post-traumatic Infection |
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| Recruiting | N/A | 170 | US | Immunofluorescence Imaging, DCE-MRI | Dartmouth-Hitchcock Medical Center, Dartmouth College, University of Maryland, Baltimore, University of California, Irvine | Trauma Injury | 12/24 | 12/25 | | |
COPE, NCT04274530: Cognitive Behavioural Therapy to Optimize Post-Operative Recovery Trial |
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| Recruiting | N/A | 1000 | Canada, US | Cognitive Behavioural Therapy, CBT | McMaster University, Orthopaedic Trauma Association, Canadian Institutes of Health Research (CIHR) | Pain, Postoperative, Pain, Acute, Pain, Chronic, Fractures, Closed, Fractures, Open | 08/25 | 08/25 | | |
NCT06249126: Primary Subtalar Arthrodesis for Calcaneal Fractures |
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| Recruiting | N/A | 218 | US | Primary Fusion (Open Reduction Internal Fixation (ORIF) + Primary Subtalar Arthrodesis (PSTA), Open Reduction Internal Fixation (ORIF) only | Wake Forest University Health Sciences | Calcaneus Fracture | 12/26 | 12/26 | | |
NCT04416412: ICG Fluorescence Imaging in Open Fracture Trauma Patients |
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| Recruiting | N/A | 180 | US | Immunofluorescence Imaging | Dartmouth-Hitchcock Medical Center, Dartmouth College, United States Department of Defense, Brigham and Women's Hospital, University of California, Irvine, University of Maryland, Baltimore | Trauma Injury | 01/25 | 01/26 | | |
| Recruiting | N/A | 1100 | Europe, Canada, US, RoW | Accelerated medical clearance and surgery | Population Health Research Institute, Canadian Institutes of Health Research (CIHR), National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) | Hip Fractures, Myocardial Injury | 02/27 | 05/27 | | |
NCT05947058: Minimally Displaced Femoral Neck Fracture Pilot Study |
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| Recruiting | N/A | 40 | Europe, Canada, US | Arthroplasty, Internal Fixation | University of Maryland, Baltimore, Orthopaedic Trauma Association, McMaster University, University of Southern California | Femoral Neck Fractures | 12/25 | 12/25 | | |
| Sprague, Sheila |
| Completed | 4 | 8485 | Canada, US | DuraPrep, ChloraPrep | University of Maryland, Baltimore, McMaster University, Patient-Centered Outcomes Research Institute | Surgical Site Infection, Unplanned Fracture-Related Reoperation, Open Appendicular Fracture, Closed Lower Extremity Fracture, Pelvic Fracture | 03/23 | 02/24 | | |
| Recruiting | N/A | 100 | Europe, Canada | Antegrade femoral nailing Supine Position, Antegrade Femoral Nailing Lateral Position | Hamilton Health Sciences Corporation, Canadian Institutes of Health Research (CIHR), Hamilton Academic Health Sciences Organization, Canadian Orthopaedic Trauma Society | Femur Fracture | 06/22 | 06/23 | | |
COPE, NCT04274530: Cognitive Behavioural Therapy to Optimize Post-Operative Recovery Trial |
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| Recruiting | N/A | 1000 | Canada, US | Cognitive Behavioural Therapy, CBT | McMaster University, Orthopaedic Trauma Association, Canadian Institutes of Health Research (CIHR) | Pain, Postoperative, Pain, Acute, Pain, Chronic, Fractures, Closed, Fractures, Open | 08/25 | 08/25 | | |
NCT05947058: Minimally Displaced Femoral Neck Fracture Pilot Study |
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| Recruiting | N/A | 40 | Europe, Canada, US | Arthroplasty, Internal Fixation | University of Maryland, Baltimore, Orthopaedic Trauma Association, McMaster University, University of Southern California | Femoral Neck Fractures | 12/25 | 12/25 | | |
| Bhandari, Mohit |
| Completed | 4 | 8485 | Canada, US | DuraPrep, ChloraPrep | University of Maryland, Baltimore, McMaster University, Patient-Centered Outcomes Research Institute | Surgical Site Infection, Unplanned Fracture-Related Reoperation, Open Appendicular Fracture, Closed Lower Extremity Fracture, Pelvic Fracture | 03/23 | 02/24 | | |
| Recruiting | 4 | 120 | Europe, Canada, US, RoW | Metabolic surgery, Bariatric surgery, Roux-en-Y Gastric Bypass (RYGB), Sleeve Gastrectomy (SG), Incretin-Based Therapy, Glucagon-like Peptide-1 Receptor Agonist | Ali Aminian | Metabolic Dysfunction-associated Steatotic Liver Disease (MASLD), Non-Alcoholic Fatty Liver Disease, Metabolic Dysfunction-Associated Steatohepatitis (MASH), Liver Fibrosis, Obesity | 05/29 | 12/29 | | |
| Completed | 3 | 319 | Europe | Apixaban Oral Tablet, Eliquis, Dabigatran, Pradaxa, Edoxaban Tablets, Lixiana, Savaysa, Rivaroxaban, Xarelto | Imperial College London, Wuerzburg University Hospital, Julius-Maximilians University, Medical University of Graz, University of Liverpool, King's College London, Hospital Universitari Vall d'Hebron Research Institute, University of Bordeaux, Azienda Ospedaliera di Perugia, Aalborg University, STROKE ALLIANCE FOR EUROPE, University Hospital Heidelberg, Imperial College Healthcare NHS Trust, Alfried Krupp Krankenhaus, University Hospital, Bordeaux | Atrial Fibrillation, Intracerebral Hemorrhage | 05/24 | 05/24 | | |
| Completed | N/A | 3001 | Europe, Canada, US, RoW | Accelerated medical clearance and surgery | McMaster University, Population Health Research Institute, Hamilton Health Sciences Corporation | Hip Fractures | 08/19 | 09/22 | | |
| Completed | N/A | 39797 | RoW | | McMaster University, Canadian Institutes of Health Research (CIHR), McMaster Surgical Associates, National Health and Medical Research Council, Australia, Hamilton Health Sciences Corporation | Fractures or Dislocations | 11/23 | 11/23 | | |
GIW-SFM, NCT06199635: Early Feasibility for Safety & Device Functionality of SFM Anastomosis Device Used in 3 Procedures (SNAP-S) or (SNAP-PS) or (J-J) |
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| Recruiting | N/A | 30 | RoW | Self-Forming Magnetic Anastomosis Device and Delivery System | GI Windows, Inc. | Morbid Obesity | 12/24 | 03/25 | | |
PREPARE, NCT05918471: PReoperative Very Low Energy Diets for Obese PAtients Undergoing Non-bariatric Surgery |
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| Recruiting | N/A | 88 | Canada | Very Low Energy Diet with Liquid Supplementation, Optifast 900 | McMaster University, Queen's University | Obesity, Non-Bariatric Surgery, Preoperative Weight Loss, Preoperative Optimization | 09/24 | 10/24 | | |
OPTIMAS, NCT03759938: OPtimal TIMing of Anticoagulation After Acute Ischaemic Stroke : a Randomised Controlled Trial |
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| Active, not recruiting | N/A | 3648 | Europe | Direct oral anticoagulant (DOAC), dabigatran, apixaban, edoxaban, rivaroxaban | University College, London | Stroke, Acute, Atrial Fibrillation | 05/24 | 10/24 | | |
| Not yet recruiting | N/A | 200 | NA | Soft Tissue Adapted Biocompatible Hyaluronic Acid | Global Research Solutions, Pendopharm | Elbow Tendinopathy, Ankle Sprains | 05/24 | 05/24 | | |
| Manson, Theodore |
NCT04630262: ATTUNE Cementless FB Tibial Base Clinical Study |
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| Terminated | N/A | 80 | US | ATTUNE Cementless CR Fixed Bearing, ATTUNE Cementless PS Fixed Bearing | DePuy Orthopaedics | Osteoarthritis of the Knee | 03/23 | 03/23 | | |
| Sciadini, Marcus |
NCT04730739: FastFrame Knee Spanning and Damage Control Kit PMCF |
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| Terminated | N/A | 36 | US | FastFrame External Fixation System - Knee Spanning or Damage Control Kit | Zimmer Biomet | Fracture, Fractures, Bone, Fractures, Closed, Fractures, Open | 06/24 | 07/24 | | |
| Phipps, Heather |
| Recruiting | 3 | 312 | Canada, US | Antibiotic Cement Bead Pouch, Negative Pressure Wound Therapy | University of Maryland, Baltimore, McMaster University | Open Tíbia Fracture | 03/25 | 10/25 | | |
NCT04403204: ICG Fluorescence Imaging in Post-traumatic Infection |
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| Recruiting | N/A | 170 | US | Immunofluorescence Imaging, DCE-MRI | Dartmouth-Hitchcock Medical Center, Dartmouth College, University of Maryland, Baltimore, University of California, Irvine | Trauma Injury | 12/24 | 12/25 | | |
NCT04416412: ICG Fluorescence Imaging in Open Fracture Trauma Patients |
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| Recruiting | N/A | 180 | US | Immunofluorescence Imaging | Dartmouth-Hitchcock Medical Center, Dartmouth College, United States Department of Defense, Brigham and Women's Hospital, University of California, Irvine, University of Maryland, Baltimore | Trauma Injury | 01/25 | 01/26 | | |
| Recruiting | N/A | 1100 | Europe, Canada, US, RoW | Accelerated medical clearance and surgery | Population Health Research Institute, Canadian Institutes of Health Research (CIHR), National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS) | Hip Fractures, Myocardial Injury | 02/27 | 05/27 | | |
NCT05947058: Minimally Displaced Femoral Neck Fracture Pilot Study |
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| Recruiting | N/A | 40 | Europe, Canada, US | Arthroplasty, Internal Fixation | University of Maryland, Baltimore, Orthopaedic Trauma Association, McMaster University, University of Southern California | Femoral Neck Fractures | 12/25 | 12/25 | | |
| Patterson, Joseph T |
| Recruiting | 3 | 312 | Canada, US | Antibiotic Cement Bead Pouch, Negative Pressure Wound Therapy | University of Maryland, Baltimore, McMaster University | Open Tíbia Fracture | 03/25 | 10/25 | | |
PIVOT-LC1-Pi, NCT06496867: Early Internal Fixation Versus NonOperative Care with Early Rehabilitation for LC1 Fragility Fractures of the Pelvis |
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| Recruiting | N/A | 48 | US | Early Internal Fixation, Nonoperative Care with Early Rehabilitation | University of Southern California, Orthopaedic Trauma Association, McMaster University, University of Maryland, Baltimore | Multiple Closed Pelvic Fractures with Disruption of Pelvic Ring, Fragility Fracture, Internal Fixation, Nonoperative Care | 12/26 | 12/27 | | |
| Active, not recruiting | N/A | 31 | US | Pelvic Binder Radiography | University of Southern California | Pelvic Fracture | 12/23 | 12/25 | | |
NCT05947058: Minimally Displaced Femoral Neck Fracture Pilot Study |
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| Recruiting | N/A | 40 | Europe, Canada, US | Arthroplasty, Internal Fixation | University of Maryland, Baltimore, Orthopaedic Trauma Association, McMaster University, University of Southern California | Femoral Neck Fractures | 12/25 | 12/25 | | |
