| Annema, Jouke |
| Recruiting | N/A | 25 | Europe | needle-based confocal laser endomicroscopy, cone beam computed tomography navigation bronchoscopy | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Lung Neoplasm, Peripheral Lung Parenchyma Tumor, Lung Cancer | 07/25 | 07/25 | | |
| Not yet recruiting | N/A | 30 | Europe | Ablation | Creo Medical Limited | Lung Cancer | 12/25 | 02/26 | | |
| Recruiting | N/A | 208 | Europe, US, RoW | Neelde Based Confocal Laser Endomicroscopy, Conventional diagnostic bronchoscopy | Amsterdam University Medical Centers (UMC), Location Academic Medical Center (AMC), Mauna Kea Technologies | Lung Cancer, Lung Neoplasm Malignant, Carcinoma, Non-Small-Cell Lung, Neoplasm of Lung | 10/25 | 10/25 | | |
| Laarhoven, Hanneke WM |
| Active, not recruiting | 2 | 41 | Europe | Tocilizumab 20 Mg/mL Intravenous Solution, RoActemra, L04AC07, Paclitaxel, L01CD01, Carboplatin, L01XA02, External beam radiotherapy | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Noordwest Ziekenhuisgroep | Esophageal Adenocarcinoma, Oesophageal Adenocarcinoma, Resectable Carcinoma | 10/22 | 04/28 | | |
TAPESTRY, NCT04595149: Tapestry: Addition of TGF-β and PDL-1 Inhibition to Definitive Chemoradiation in Esophageal Squamous Cell Carcinoma |
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| Recruiting | 2 | 52 | Europe | Bintrafusp alfa, M7824 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Neoplasm, Esophagus, Malignant Esophagus Tumor, Neoplasm, Esophageal | 11/23 | 11/28 | | |
| Active, not recruiting | 2 | 207 | Europe | Docetaxel, Taxotere, Oxaliplatin, Eloxatin, Capecitabine, Xeloda, gastrectomy, radiotherapy of gastric cancer, Paclitaxel, Carboplatin | The Netherlands Cancer Institute | Gastric Cancer | 04/25 | 03/29 | | |
MEMENTO, NCT06687876: Metformin as a Metabolic Intervention in Oesophageal Adenocarcinomas to Improve Response to Neoadjuvant Chemoradiotherapy |
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| Not yet recruiting | 2 | 14 | Europe | Metformin, Glucient | Amsterdam UMC, location VUmc, Cancer Center Amsterdam Research Foundation | Oesophageal Adenocarcinoma, Tumor Microenvironment | 12/26 | 12/30 | | |
| Recruiting | 2 | 25 | Europe | Capecitabine, Xeloda, Oxaliplatin, Oxaliplatin Accord, Retifanlimab, INCMGA00012 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Incyte Corporation | Gastric Adenocarcinoma, Esophageal Adenocarcinoma | 05/25 | 11/29 | | |
PRIDE, NCT03474341: Preoperative Image-guided Identification of Response to Neoadjuvant Chemoradiotherapy in Esophageal Cancer |
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| Recruiting | N/A | 200 | Europe | MRI, Magnetic Resonance Imaging, DW-MRI, DCE-MRI, T2W, PET-CT, 18-F FDG PET-CT, PET, Endoscopy, Endoscopic assessment, EUS, Blood samples, ctDNA | UMC Utrecht, University Medical Center Groningen, The Netherlands Cancer Institute, Koningin Wilhelmina Fonds, Amsterdam UMC, location VUmc | Esophageal Cancer, Esophageal Adenocarcinoma, Esophageal Squamous Cell Carcinoma, Esophageal Neoplasms | 09/21 | 01/22 | | |
TAPESTRY, NCT04481256: TGF-β And PDL-1 Inhibition in Esophageal Squamous Cell Carcinoma Combined With Chemoradiation TheRapY |
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| Recruiting | N/A | 49 | Europe | External beam radiotherapy, Bintrafusp alfa, M7824, Paclitaxel, Taxol, Carboplatin | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), UMC Utrecht, Catharina Ziekenhuis Eindhoven, Institute Verbeeten, Elisabeth-TweeSteden Ziekenhuis, Leiden University Medical Center, Radiotherapeutic Institute Friesland, Medical Centre Leeuwarden, Radiotherapy Group Deventer, Deventer Ziekenhuis, Rijnstate Hospital, Erasmus Medical Center, The Netherlands Cancer Institute, Isala, University Medical Center Groningen, Ziekenhuisgroep Twente | Carcinoma, Squamous Cell, Oesophageal Cancer | 09/25 | 09/30 | | |
SOURCE, NCT04232735: Evidence Based Information Provision to Improve Decision Making After Oesophagogastric Cancer Diagnosis |
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| Recruiting | N/A | 126 | Europe | Tool and training | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Dutch Cancer Society | Oesophageal Cancer, Gastric Cancer | 09/23 | 09/23 | | |
RADICES, NCT06138223: The Effect of exeRcise And Diet on Quality of Life in Patients With Incurable Cancer of Esophagus and Stomach |
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| Recruiting | N/A | 196 | Europe | Exercise intervention, Nutrition intervention | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), UMC Utrecht | GastroEsophageal Cancer, Incurable Disease | 09/28 | 09/28 | | |
NICI, NCT04534543: MAESTRO Study: Metabolic Imaging to Improve Patient-Specific Therapy Outcomes |
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| Recruiting | N/A | 70 | Europe | MRI/Spectroscopy | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), UMC Utrecht | Gastrointestinal Cancer Metastatic | 02/27 | 02/27 | | |
| Tanis, PJ |
| Recruiting | N/A | 478 | Europe | XELOX regimen according to standard procedures, FOLFOX regimen according to standard procedures, Surgery, radiofrequency ablation (RFA), transarterial chemo-embolization using irinotecan drug-eluted beads ((DEBIRI-)TACE), stereotactic body radiation therapy (SBRT), Bevacizumab, tumor biopsy | Radboud University Medical Center, Erasmus Medical Center | Multi-organ Metastatic Colorectal Cancer | 07/23 | 07/25 | | |
| Recruiting | N/A | 50000 | Europe | | Dutch Colorectal Cancer Group | Colorectal Cancer | 01/50 | 01/51 | | |
| Knops, Reinoud E |
PRAETORIAN, NCT01296022: A PRospective, rAndomizEd Comparison of subcuTaneOous and tRansvenous ImplANtable Cardioverter Defibrillator Therapy |
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| Active, not recruiting | N/A | 850 | Europe, US, RoW | Implantation of subcutaneous ICD, Implantation of transvenous ICD | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Boston Scientific Corporation | Ventricular Arrhythmias | 12/19 | 12/23 | | |
CRT-DRIVE, NCT05327062: Cardiac Resynchronization Therapy Delivery Guided Non-Invasive Electrical and Venous Anatomy Assessment |
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| Recruiting | N/A | 150 | Europe, US | CRT implantation guided by XSpline, a non-invasive electrical and venous anatomy assessment | XSpline S.p.A. | Cardiac Resynchronization Therapy, Chronic Heart Failure, Left Bundle-Branch Block | 03/25 | 09/25 | | |
| Active, not recruiting | N/A | 1686 | Europe, Canada, Japan, US, RoW | SyncAV programmed ON, Fixed AV delay | Abbott Medical Devices | Congestive Heart Failure | 06/25 | 12/25 | | |
| Active, not recruiting | N/A | 965 | Europe, US | ommitence of defibrillation testing | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Boston Scientific Corporation | Ventricular Arrythmia | 10/24 | 10/24 | | |
MODULAR ATP, NCT04798768: Effectiveness of the EMPOWER™ Modular Pacing System and EMBLEM™ Subcutaneous ICD to Communicate Antitachycardia Pacing |
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| Active, not recruiting | N/A | 297 | Europe, Canada, US, RoW | mCRM Therapy System, Communication of S-ICD to Leadless Cardiac Pacemaker (LCP) | Boston Scientific Corporation | Tachycardia, Ventricular, Arrhythmia, Ventricular | 03/25 | 12/30 | | |
NCT06048731: Enlighten Study: The EV-ICD Post Approval Registry |
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| Recruiting | N/A | 1000 | Europe, Canada, US, RoW | Defibrillation using EV-ICD | Medtronic | Ventricular Arrhythmia, Tachycardia | 05/30 | 10/37 | | |
| D'Haens, Geert |
| Completed | 4 | 260 | Europe | vedolizumab, Entyvio | Geert D'Haens, Takeda | Crohn Disease | 05/23 | 05/23 | | |
| Active, not recruiting | 4 | 672 | Europe, Canada, US, RoW | Treatment Algorithm A, vedolizumab, Treatment Algorithm B, Treatment Algorithm C | Alimentiv Inc., Takeda Development Center Americas, Inc. | Colitis, Ulcerative | 03/26 | 03/26 | | |
| Recruiting | 3 | 612 | Europe, Canada, US, RoW | ABX464, Obefazimod, Placebo | Abivax S.A. | Ulcerative Colitis | 03/25 | 04/25 | | |
| Recruiting | 3 | 1050 | Europe, Canada, Japan, US, RoW | ABX464, Obefazimod, Placebo | Abivax S.A. | Ulcerative Colitis | 01/26 | 01/30 | | |
NCT06233461: A Study on the Safety of TAK-279 and Whether it Can Reduce Inflammation in the Bowel of Participants With Moderately to Severely Active Crohn's Disease |
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| Recruiting | 2 | 268 | Europe, Canada, Japan, US, RoW | TAK-279, Zasocitinib, Placebo | Takeda | Crohn's Disease | 09/26 | 07/27 | | |
DIVE-23, NCT06006039: The Role of IL-23-Responsive Immune Cell Subsets in Post-Operative Recurrence in Patients With Crohn's Disease. |
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| Recruiting | N/A | 40 | Europe, Canada | | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Crohn´s Disease | 01/26 | 11/26 | | |
| Laarhoven, H WM van |
| Recruiting | 3 | 376 | Europe | Trastuzumab, Pertuzumab, Paclitaxel, Carboplatin | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Esophageal Cancer, Esophageal Adenocarcinoma | 07/27 | 02/37 | | |
| Recruiting | 2 | 122 | Europe | S1 + Nal-IRI, Nal-IRI+Leucovorin+5-FU | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), UMC Utrecht, Isala, Maastricht University Medical Center, Vall de Hebron, Barcelona, Spain, University Hospital Verona, Italy, Odense University Hospital, Medical University of Vienna | Metastatic Pancreatic Cancer | 01/22 | 01/22 | | |
| Recruiting | 2 | 320 | Europe | Liposomal Irinotecan, Carboplatin, Capecitabine, Xeloda, Oxaliplatin, 5-fluorouracil, Leucovorin | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Servier | Esophageal Cancer | 07/25 | 07/26 | | |
| Recruiting | 2 | 25 | Europe | Capecitabine, Xeloda, Oxaliplatin, Oxaliplatin Accord, Retifanlimab, INCMGA00012 | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Incyte Corporation | Gastric Adenocarcinoma, Esophageal Adenocarcinoma | 05/25 | 11/29 | | |
OPT-1, NCT03500068: Establishing Organoids From Metastatic Pancreatic Cancer Patients, the OPT-I Study. |
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| Recruiting | N/A | 30 | Europe | biopsies & blood analyses | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Erasmus Medical Center | Carcinoma, Pancreatic Ductal | 09/22 | 09/22 | | |
TAPESTRY, NCT04481256: TGF-β And PDL-1 Inhibition in Esophageal Squamous Cell Carcinoma Combined With Chemoradiation TheRapY |
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| Recruiting | N/A | 49 | Europe | External beam radiotherapy, Bintrafusp alfa, M7824, Paclitaxel, Taxol, Carboplatin | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), UMC Utrecht, Catharina Ziekenhuis Eindhoven, Institute Verbeeten, Elisabeth-TweeSteden Ziekenhuis, Leiden University Medical Center, Radiotherapeutic Institute Friesland, Medical Centre Leeuwarden, Radiotherapy Group Deventer, Deventer Ziekenhuis, Rijnstate Hospital, Erasmus Medical Center, The Netherlands Cancer Institute, Isala, University Medical Center Groningen, Ziekenhuisgroep Twente | Carcinoma, Squamous Cell, Oesophageal Cancer | 09/25 | 09/30 | | |
SOURCE, NCT04232735: Evidence Based Information Provision to Improve Decision Making After Oesophagogastric Cancer Diagnosis |
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| Recruiting | N/A | 126 | Europe | Tool and training | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Dutch Cancer Society | Oesophageal Cancer, Gastric Cancer | 09/23 | 09/23 | | |
| Dieleman, Edith |
HALO, NCT03984019: Cardiac Changes After Stereotactic Radiotherapy for Early Stage NSCLC Cancer or Lung Metastasis |
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| Terminated | N/A | 10 | Europe | Cardiac condition measurements | The Netherlands Cancer Institute, Dutch Cancer Society | Lung Cancer Stage I, Lung Cancer Stage II, Lung Metastases | 04/23 | 04/23 | | |
| Recruiting | N/A | 94 | Europe | LINAC-based Stereotactic Radiotherapy | Maastricht Radiation Oncology, Maastricht University Medical Center, UMC Utrecht, Amsterdam University Medical Center, ZonMw: The Netherlands Organisation for Health Research and Development | Epilepsy | 01/28 | 01/28 | | |
| Bonta, Peter I |
| Recruiting | N/A | 600 | Europe | | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Bispebjerg Hospital, University Hospitals, Leicester, Karolinska Institutet, University Medical Center Groningen | Severe Asthma | | | | |
NCT02975284: Unraveling Targets of Therapy in Bronchial Thermoplasty in Severe Asthma (TASMA) Extension Study |
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| Active, not recruiting | N/A | 30 | Europe | | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), University Medical Center Groningen | Severe Asthma | 09/24 | 09/24 | | |
| Active, not recruiting | N/A | 464 | Europe, US | Targeted Lung Denervation (TLD), TLD, TLD Therapy, Optimal Medical Care | Nuvaira, Inc. | COPD | 10/24 | 09/28 | | |
| Recruiting | N/A | 25 | Europe | needle-based confocal laser endomicroscopy, cone beam computed tomography navigation bronchoscopy | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Lung Neoplasm, Peripheral Lung Parenchyma Tumor, Lung Cancer | 07/25 | 07/25 | | |
| Recruiting | N/A | 208 | Europe, US, RoW | Neelde Based Confocal Laser Endomicroscopy, Conventional diagnostic bronchoscopy | Amsterdam University Medical Centers (UMC), Location Academic Medical Center (AMC), Mauna Kea Technologies | Lung Cancer, Lung Neoplasm Malignant, Carcinoma, Non-Small-Cell Lung, Neoplasm of Lung | 10/25 | 10/25 | | |
| Bemelman, Willem A |
PISA-II, NCT06441526: Surgical Closure vs Anti-TNF in the Treatment of Perianal Fistulas in Crohn's Disease (): a Comprehensive Cohort Design |
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| Completed | 3 | 94 | Europe | anti-tumour necrosis factor α antibodies, Advancement plasty, Ligation of the intersphincteric tract (LIFT) | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Perianal Fistula, Crohn Disease | 12/19 | 06/21 | | |
SPICY, NCT04538638: Mesenteric SParIng Versus Central mesenterectomY in Ileocolic Resection for Terminal Ileitis in Crohn's Disease |
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| Completed | N/A | 139 | Europe | Mesenteric sparing ileocolic resection, Central mesenterectomy ileocolic resection | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Crohn's Disease | 05/23 | 11/23 | | |
| Recruiting | N/A | 298 | Europe | Ciprofloxacin 500 mg, Metronidazole 500 mg, Placebo | dr. IJM Han-Geurts, Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Perianal Fistula, Perianal Abscess, Drain Abscess | 12/24 | 08/25 | | |
HollAND, NCT04621695: Comparison of Rubber Band Ligation and Haemorrhoidectomy in Patients With Symptomatic Haemorrhoids Grade III |
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| Recruiting | N/A | 360 | Europe | RBL, Hemorrhoidectomy | Proctos Kliniek | Hemorrhoids, Hemorrhoids, Internal, PROM, Rectal Diseases | 11/23 | 11/23 | | |
| Dekker, Evelien |
| Completed | N/A | 52 | Europe | SCALE EYE | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Polyp of Colon | 03/23 | 03/23 | | |
mtFIT, NCT05314309: Prospective Clinical Validation of a Novel Multitarget FIT in CRC Screening |
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| Active, not recruiting | N/A | 14712 | Europe | Comparison of two tests (FIT and mtFIT) in the same bowel movement | The Netherlands Cancer Institute, Amsterdam University Medical Centres (AUMC), Erasmus Medical Center | CRC, Advanced Neoplasia | 05/23 | 05/23 | | |
| Recruiting | N/A | 50 | Europe | NEXPOWDER-ENDOHS | Erasme University Hospital | Gastro Intestinal Bleeding, Polyps | 04/24 | 07/24 | | |
NCT04678011: A Personalized Surveillance and Intervention Protocol for Patients With Familial Adenomatous Polyposis That Have Undergone (Procto)Colectomy |
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| Recruiting | N/A | 1000 | Europe | Personalized surveillance and intervention protocol | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Leiden University Medical Center, The Netherlands Cancer Institute, St Mark's Hospital Foundation, Hospital Clinic of Barcelona, Hôpital Edouard Herriot, Maria Sklodowska-Curie Institute - Oncology Center, Hospital General Universitario de Alicante, University Medical Center Mainz, St. Orsola Hospital | Familial Adenomatous Polyposis | 11/25 | 11/25 | | |
NCT04677998: A Personalized Surveillance and Intervention Protocol for Duodenal and Gastric Polyposis in Patients With Familial Adenomatous Polyposis |
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| Recruiting | N/A | 1000 | Europe | Personalized surveillance and intervention protocol | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Leiden University Medical Center, The Netherlands Cancer Institute, St Mark's Hospital Foundation, Hospital Clinic of Barcelona, Hôpital Edouard Herriot, Maria Sklodowska-Curie Institute - Oncology Center, Hospital General Universitario de Alicante, University Medical Center Mainz, St. Orsola Hospital | Familial Adenomatous Polyposis | 11/25 | 11/25 | | |
| Hooft, Jeanin van |
| Recruiting | N/A | 200 | Europe | Endoscopic Ultrasound registration | Erasmus Medical Center | Hilar Cholangiocarcinoma, Intrahepatic Cholangiocarcinoma, Common Bile Duct Neoplasms, Cholangiocarcinoma, Adenocarcinoma | 02/25 | 02/26 | | |
| Ganzevoort, Wessel |
| Completed | 1 | 257 | Europe, Canada | Aspirin 81 mg, acetylsalicylic acid, ASA, Placebo | University of Calgary, Canadian Institutes of Health Research (CIHR), Canadian Venous Thromboembolism Clinical Trials and Outcomes Research (CanVECTOR) Network | Venous Thromboembolism, Postpartum Period, Aspirin | 09/23 | 09/23 | | |
| Not yet recruiting | N/A | 800 | NA | Short term variation, Visual interpretation | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Fetal Growth Retardation | 01/27 | 01/29 | | |
| lowenberg, mark |
| Recruiting | 3 | 1063 | Europe, Canada, Japan, US, RoW | Mirikizumab, LY3074828 | Eli Lilly and Company | Ulcerative Colitis | 07/26 | 12/27 | | |
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| Recruiting | 2/3 | 10 | Europe | Fibroblast Activation Protein Inhibitor, FAPi PET CT scan | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Ulcerative Colitis (UC), Inflammatory Bowel Disease (IBD), Fibroblast Activation Protein Inhibitor | 10/25 | 04/26 | | |
| Recruiting | 2 | 20 | Europe | 68Ga-FAPi-46, FAPi-scan | Dalia Lartey | IBD (Inflammatory Bowel Disease), Crohn Disease (CD), Ulcerative Colitis (UC) | 12/24 | 12/24 | | |
| D'Haens, G |
| Recruiting | 4 | 120 | Europe | Infliximab, Remicade, Inflectra and Remsima | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Pfizer | Colitis, Ulcerative | 12/24 | 12/24 | | |
| Recruiting | 3 | 158 | Europe | Infliximab subcutaneous, Remsima 120mg solution s.c., Immunosuppressive Agents, 6-mercaptopurine 1-1.5 mg/kg oral, or, if already on oral azathioprine or thioguanine continuous dosing 2-2.5mg/kg, or 20mg once daily respectively, In case of adverse events or investigator's individual consideration, instead of thiopurine, methotrexate 15 mg/week s.c. (or oral) in combination with oral folic acid 5 mg/week | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Celltrion | Inflammatory Disease, Disease Crohn, Bowel Disease | 01/24 | 07/24 | | |
| Roos, Yvo B |
| Recruiting | 3 | 776 | Europe | Acetylsalicylic acid, aspirin, intensive blood pressure control | Universitätsmedizin Mannheim, UMC Utrecht, Schwiete Stiftung, Mannheim, Germany, KKS Netzwerk, University of Hamburg-Eppendorf | Unruptured Intracranial Aneurysms | 10/22 | 10/22 | | |
| Completed | 3 | 850 | Europe, Canada, US, RoW | Placebo, Nerinetide, NA-1 | NoNO Inc., University of Calgary | Stroke, Acute | 08/23 | 08/23 | | |
| Beuers, Ulrich |
CAMARO, NCT02900443: Mycophenolate Mofetil Versus Azathioprine in Treatment Naive Autoimmune Hepatitis |
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| Active, not recruiting | 4 | 70 | Europe | Mycophenolate mofetil, Azathioprine | Radboud University Medical Center, Leiden University Medical Center | Autoimmune Hepatitis | 06/23 | 06/23 | | |
NCT01618890: Hepatic Venous Pressure Gradient-guided Versus Standard Beta-blocker Therapy in Primary Prevention of Variceal Bleeding |
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| Recruiting | 3 | 78 | Europe | Hepatic venous pressure gradient measurement, Hepatic venous pressure measurement, Endoscopic variceal band ligation, Propranolol | Leiden University Medical Center, Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Free University Medical Center, Haga Hospital, Universitaire Ziekenhuizen Leuven, Ziekenhuis Netwerk Antwerpen (ZNA) | Acute Bleeding Esophageal Varices, Liver Cirrhosis | 12/20 | 12/22 | | |
PACIFIC, NCT05525520: Study to Evaluate EP547 in Subjects With Cholestatic Pruritus Due to Primary Biliary Cholangitis or Primary Sclerosing Cholangitis |
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| Completed | 2 | 62 | Europe, Canada, US, RoW | EP547, Placebo | Escient Pharmaceuticals, Inc | Pruritus | 07/24 | 09/24 | | |
| Active, not recruiting | 2 | 72 | Europe, RoW | Obeticholic acid, Bezafibrate 200 MG, OCA Placebo, Bezafibrate 200 mg Placebo, Bezafibrate 400 MG, Bezafibrate 400 mg Placebo, OCA, Bezafibrate | Intercept Pharmaceuticals | Primary Biliary Cholangitis | 10/25 | 10/25 | | |
| Recruiting | 1/2 | 17 | Europe | GNT0003 | Genethon | Crigler-Najjar Syndrome | 03/26 | 03/30 | | |
| Recruiting | N/A | 10000 | Europe | | Newcastle University, Newcastle-upon-Tyne Hospitals NHS Trust, Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Institute of Cardiometabolism and Nutrition, France, University of Cambridge, Örebro University, Sweden, University of Bern, University of Oxford, University of Turin, Italy, University of Angers, University Hospital, Antwerp, Linkoeping University, University of Helsinki, UMC Utrecht, National and Kapodistrian University of Athens, University of Lisbon, University of Milan, University of Palermo, Catholic University of the Sacred Heart, Wuerzburg University Hospital, RWTH Aachen University, University of Nottingham, Medical University of Vienna, University of Birmingham, University of Florence, Assistance Publique - Hôpitaux de Paris, University Medical Center Mainz | NAFLD, NASH, NASH - Nonalcoholic Steatohepatitis, Fibrosis, Liver, Steatosis of Liver, Hepatocellular Carcinoma, Cardiovascular Diseases, Type 2 Diabetes, Dyslipidaemia, Hypertension, Obesity, Other Associated Comorbidities | 12/30 | 12/30 | | |
| Vlaar, Alexander |
| Active, not recruiting | 2 | 280 | Europe | Anakinra or rhIFNγ, Imukin, Kineret, Placebo | Hellenic Institute for the Study of Sepsis | Sepsis | 01/25 | 04/25 | | |
| Completed | 1 | 10 | Europe | M6229 | A.P.J. Vlaar, Matisse Pharmaceuticals, Maastricht University, Maastricht University Medical Center | Sepsis, Septic Shock, Critical Illness | 09/23 | 09/23 | | |
| Not yet recruiting | N/A | 210 | NA | Blood sample collection, Blood draw | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Transfusion-Related Acute Lung Injury, ARDS, Human | 09/25 | 12/25 | | |
| Not yet recruiting | N/A | 526 | Europe | Red Blood Cell transfusion, RBC transfusion, pRBCs, packed Red Blood Cells | Amsterdam University Medical Centers (UMC), Location Academic Medical Center (AMC), ZonMw: The Netherlands Organisation for Health Research and Development | Transfusion, Red Blood Cell, Extracorporeal Membrane Oxygenation, Anemia, ECMO | 12/27 | 12/28 | | |
NOTICE, NCT05303363: Monitoring of Cerebral Blood Flow in Patients on Extracorporeal Membrane Oxygenation |
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| Recruiting | N/A | 15 | Europe | VV-ECMO | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Extracorporeal Membrane Oxygenation Complication, Cerebral Circulatory Failure | 06/25 | 08/25 | | |
| Schultz, Marcus J |
| Completed | N/A | 2793 | Europe, RoW | intraoperative mechanical ventilation with hypocapnia (etCO2 < 35 mm Hg) | NMC Specialty Hospital, Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Hospital Israelita Albert Einstein, University Hospital Carl Gustav Carus, Hospital Clínico Universitario de Valencia | Mechanical Ventilation Complication, Surgery, Pulmonary Complication, Intraoperative Complications, Postoperative Complications | 01/23 | 03/23 | | |
| Completed | N/A | 96 | Europe | Procedure: INTELLiVENT-ASV, Procedure: Conventional ventilation | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Reinier de Graaf Groep, Dijklander Ziekenhuis, University of Zurich | Mechanical Ventilation, Mechanical Power | 04/23 | 07/23 | | |
| Recruiting | N/A | 1000 | Europe | Lung ultrasound guided deresuscitation | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), ZonMw: The Netherlands Organisation for Health Research and Development | Mechanical Ventilation, Fluid Overload, Deresuscitation, Ventilator-free Days | 12/24 | 12/25 | | |
| Recruiting | N/A | 1468 | Europe | Individualized high PEEP strategy | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Amsterdam UMC, location VUmc, Noord West Ziekenhuizen location Alkmaar, University Medical Center Groningen, Radboud University Medical Center, HagaZiekenhuis, Rijnstate Hospital, Medical Center Haaglanden, Bernhoven Hospital, Onze Lieve Vrouwe Gasthuis, Albert Schweitzer Hospital, Medical Centre Leeuwarden, Leiden University Medical Center, Maastricht University Medical Center, Martini Hospital Groningen, Erasmus Medical Center, Spaarne Gasthuis, University Hospital Carl Gustav Carus, Bermanntrost BG Klinikum Halle, Heinrich-Heine University, Duesseldorf, Ospedale Policlinico San Martino, Jeroen Bosch Ziekenhuis, Meander Medical Center, Isala, Alrijne Hospital, Antoni van Leeuwenhoek Ziekenhuis, Medisch Spectrum Twente, Campus Bio-Medico University, Istituto Nazionale Tumori IRCCS - Fondazione G. Pascale, University of Roma La Sapienza, University of Campania "Luigi Vanvitelli", Hospital Universitario La Fe, Medical University Innsbruck | Postoperative Respiratory Complication | 06/25 | 06/25 | | |
| Completed | N/A | 3270 | Europe | Invasive ventilation | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Invasive Ventilation | 07/24 | 07/24 | | |
| Completed | N/A | 8000 | Europe | Invasive ventilation., Respiratory support. | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Invasive Ventilation | 07/24 | 07/24 | | |
| Recruiting | N/A | 10000 | Europe, RoW | | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Mechanical Ventilation Complication, Pediatric ALL, Pulmonary Complication, Perioperative/Postoperative Complications | 04/25 | 05/25 | | |
NCT05345743: The Incidence of Postoperative Pulmonary Complications in Patients With a Positive and Negative AIR-Test During General Anesthesia |
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| Completed | N/A | 632 | Europe | Surgery | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Surgery--Complications, Atelectasis, Anesthesia | 06/24 | 06/24 | | |
| Not yet recruiting | N/A | 2500 | NA | | University Medical Center Groningen, Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Critical Illness, Respiratory Failure | 04/34 | 04/34 | | |
| Not yet recruiting | N/A | 10000 | NA | Intraoperative mechanical ventilation for surgery | Azienda Ospedaliero Universitaria Maggiore della Carita, University Of Perugia, University of Chieti, Medical University of Vienna, The Netherlands Cancer Institute, Monash University | Surgery, Ventilator Lung, Postoperative Complications | 10/24 | 03/25 | | |
| Recruiting | N/A | 2500 | Europe | | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Mahidol Oxford Tropical Medicine Research Unit, Amsterdam UMC, location VUmc, University Hospital, Antwerp | Fluid Therapy, Vasopressor Therapy, Critical Illness, Invasive Ventilation | 07/25 | 07/25 | | |
| Completed | N/A | 137 | Europe | | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Centre Hospitalier Universitaire de Brussels, Brussels, Belgium, Miulli Regional Hospital, Acquaviva delle Fonti, Italy, University of Foggia, University of Bari Aldo Moro | Covid19, Ultrasound, ARDS | 12/20 | 12/20 | | |
ACTiVE, NCT04593810: Effect of Automated Closed-Loop Ventilation Versus Conventional Ventilation on Duration and Quality of Ventilation |
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| Recruiting | N/A | 1200 | Europe | INTELLiVENT-ASV, CONVENTIONAL VENTILATION | Prof. Dr. Marcus J. Schultz, ZonMw: The Netherlands Organisation for Health Research and Development, Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Catharina Ziekenhuis Eindhoven, Reinier de Graaf Groep, Flevoziekenhuis, Leiden University Medical Center, Canisius-Wilhelmina Hospital, Elisabeth-TweeSteden Ziekenhuis, Diakonessenhuis, Utrecht, Ospedale Policlinico San Martino, Fondazione IRCCS Policlinico San Matteo di Pavia | Ventilator-free Days, Quality of Breathing | 03/25 | 06/25 | | |
| Recruiting | N/A | 50 | Europe | Mechanical Insufflation-Exsufflation, Cough assist | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA) | Critically Ill | 05/25 | 06/25 | | |
| Recruiting | N/A | 1806 | Europe | Intraoperative ventilation with individualized high PEEP titrated to the lowest ΔP with RMs, Individualized high PEEP strategy with recruitment maneuvers | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), Onze Lieve Vrouwe Gasthuis, HagaZiekenhuis, Dijklander Ziekenhuis, The Netherlands Cancer Institute, Isala, Maasstad Hospital, Medisch Spectrum Twente, University Medical Center Groningen, Leiden University Medical Center, Hospital Universitario La Fe, Ospedale Policlinico San Martino, University Hospital Carl Gustav Carus, Medical University Innsbruck, Spaarne Gasthuis, Zaans Medical Center, Alrijne Hospital, Albert Schweitzer Hospital, Maastricht University Medical Center, Noordwest Ziekenhuisgroep | Postoperative Complications, Surgery | 06/27 | 09/27 | | |
| Baan, Jan |
TRACE-NL, NCT05628779: Evaluating Edge-to-edge Transcatheter Tricuspid Valve Repair in Patients With Severe Symptomatic Tricuspid Regurgitation |
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| Enrolling by invitation | N/A | 150 | Europe | TriClip TTVr system (Abbott Vascular), PASCAL TTVr system (Edwards Lifesciences) | St. Antonius Hospital, ZonMw: The Netherlands Organisation for Health Research and Development | Tricuspid Valve Regurgitation, Nonrheumatic, Cardiac Catheterization, Heart Failure, Right Sided, Valve Regurgitation, Tricuspid | 11/27 | 11/27 | | |
| Nollet, Frans |
| Completed | N/A | 21 | Europe | 3D-printed hand orthosis | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), ZonMw: The Netherlands Organisation for Health Research and Development | Hand Injuries and Disorders | 02/23 | 02/23 | | |
| Recruiting | N/A | 10 | Europe | NEURO SWING AFO (Fior& Gentz, Lüneburg In Duderstadt, Germany), WalkOn Reaction® (Ottobock, Duderstadt), Matrix Max2® (TruLife, Dublin, Ireland), Matrix® (TruLife, Dublin, Ireland) | Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA), FIOR & GENTZ | Neuromuscular Disorders | 02/25 | 02/25 | | |
| Coordinator, Site |
NCT05069597: Study to Evaluate Symptoms of Exocrine Pancreatic Insufficiency in Adult Participants With Cystic Fibrosis or Chronic Pancreatitis Treated With Creon |
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| Completed | 4 | 30 | US | CREON, Pancrelipase | AbbVie | Cystic Fibrosis, Chronic Pancreatitis | 07/23 | 08/23 | | |
NCT05647551: A Study to Evaluate Satisfaction in Adult Participants With the Aesthetics of the Periorbital Area After JUVÉDERM® Fillers and BOTOX®/VISTABEL® Injections |
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| Completed | 4 | 73 | Europe, RoW | BOTOX®/VISTABEL®, Juvéderm® VOLBELLA® with Lidocaine, Juvéderm® VOLIFT® with Lidocaine, Juvéderm® VOLUMA® with Lidocaine | AbbVie | Facial Corrections, Facial Lines | 10/23 | 10/23 | | |
NCT01192568: Safety and Efficacy Evaluation of Oxybutynin Topical Gel In Children With Neurogenic Bladder |
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| Completed | 4 | 52 | US | Oxybutynin, Gelnique, Placebo | AbbVie | Overactive Detrusor, Neurogenic Bladder | 08/23 | 10/23 | | |
NCT06218251: A Study to Evaluate Participant Satisfaction and Natural Outcomes Following Administration of BOTOX Cosmetic Injections in Adult Participants for Treatment of Upper Facial Lines |
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| Active, not recruiting | 4 | 100 | Canada, US | BOTOX, Botulinum Toxin Type A, OnabotulinumtoxinA | AbbVie | Upper Facial Lines | 07/24 | 04/25 | | |
IMMpactful, NCT06333860: A Study to Learn How Safe and Effective Risankizumab is When Compared to Deucravacitinib to Treat Participants With Moderate Plaque Psoriasis and Who Need to Try Systemic Treatment (Works Throughout the Whole Body) |
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| Recruiting | 4 | 336 | Europe, Canada, US, RoW | Risankizumab, Deucravacitinib | AbbVie | Moderate Plaque Psoriasis | 03/25 | 03/26 | | |
NCT05969223: Study to Assess the Safety and Efficacy of Subcutaneously Injected Risankizumab in Adult Participants With Genital or Scalp Psoriasis |
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| Active, not recruiting | 4 | 214 | US | Risankizumab, Skyrizi, ABBV-066, Placebo for Risankizumab | AbbVie | Genital Psoriasis, Scalp Psoriasis | 01/25 | 10/25 | | |
| Completed | 4 | 461 | Europe, Canada, Japan, RoW | Upadacitinib, RINVOQ, ABT-494 | AbbVie, AbbVie Inc. | Atopic Dermatitis | 07/24 | 08/24 | | |
VIALE-M, NCT04102020 / 2019-002217-19: A Study of Oral Venetoclax Tablets and Oral Azacitidine as Maintenance Therapy in Adult Participants With Acute Myeloid Leukemia in First Remission After Conventional Chemotherapy |
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| Active, not recruiting | 3 | 112 | Europe, Canada, Japan, US, RoW | Venetoclax, ABT-199, GDC-0199, Venclexta, Azacitidine | AbbVie, Roche-Genentech | Acute Myeloid Leukemia (AML) | 09/22 | 04/25 | | |
NCT04994535: A Study To Assess the Safety and Effects of OnabotulinumtoxinA (BOTOX) Intramuscular Injection in Adult Participants With Platysma Prominence |
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| Completed | 3 | 426 | Europe, Canada, US | OnabotulinumtoxinA, BOTOX, Placebo | AbbVie | Platysma Prominence | 06/23 | 06/23 | | |
NCT05139121: Study of the Safety and Efficacy of MR-100A-01 in Approximately 1200 Healthy Women for up to 13 Cycles |
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| Active, not recruiting | 3 | 1321 | Canada, US | MR-100A-01, Transdermal contraceptive delivery system | Mylan Technologies Inc., Mylan Inc. | Contraception | 01/25 | 01/25 | | |
NCT02814916 / 2014-005281-30: Dalbavancin for the Treatment of Acute Bacterial Skin and Skin Structure Infections in Children, Known or Suspected to be Caused by Susceptible Gram-positive Organisms, Including MRSA |
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| Completed | 3 | 199 | Europe, US, RoW | Dalbavancin, Xydalba, Vancomycin, Oxacillin, Flucloxacillin, Cefadroxil, Clindamycin | AbbVie | Methicillin-Resistant Staphylococcus Aureus, Bacterial Infections, Staphylococcal Skin Infections | 01/24 | 01/24 | | |
