| Waksman, Ron |
NCT06292013: A Study to Investigate the Effect of Lepodisiran on the Reduction of Major Adverse Cardiovascular Events in Adults With Elevated Lipoprotein(a) - ACCLAIM-Lp(a) |
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| Recruiting | 3 | 12500 | Europe, Canada, Japan, US, RoW | Lepodisiran Sodium, LY3819469, Placebo | Eli Lilly and Company | Atherosclerotic Cardiovascular Disease (ASCVD), Elevated Lp(a) | 03/29 | 03/29 | | |
V-PLAQUE, NCT05360446: Coronary Computed Tomography Study to Assess the Effect of Inclisiran in Addition to Maximally Tolerated Statin Therapy on Atherosclerotic Plaque Progression in Participants With a Diagnosis of Non-obstructive Coronary Artery Disease Without Previous Cardiovascular Events |
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| Recruiting | 3 | 600 | Europe, Canada, Japan, US, RoW | Inclisiran sodium 300 mg, Placebo | Novartis Pharmaceuticals | Coronary Artery Disease | 01/27 | 01/27 | | |
VICTORION-2P, NCT05030428: Study of Inclisiran to Prevent Cardiovascular (CV) Events in Participants With Established Cardiovascular Disease |
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| Active, not recruiting | 3 | 17006 | Europe, Canada, Japan, US, RoW | Inclisiran sodium 300 mg, Placebo | Novartis Pharmaceuticals | Atherosclerotic Cardiovascular Disease | 10/27 | 10/27 | | |
| Recruiting | N/A | 1150 | US, RoW | Portico transcatheter aortic valve, Commercially available transcatheter aortic valve | Abbott Medical Devices | Aortic Valve Stenosis | 10/19 | 07/25 | | |
NCT02799823: Transfemoral Replacement of Aortic Valve With HLT MeriDIAN Valve Early Feasibility Trial |
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| Terminated | N/A | 11 | US | HLT Transcatheter Aortic Valve System | HLT Inc. | Aortic Valve Stenosis | 01/23 | 01/23 | | |
NCT03557242: Strategies to Prevent Transcatheter Heart Valve Dysfunction in Low Risk Transcatheter Aortic Valve Replacement |
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| Active, not recruiting | N/A | 124 | US | TAVR, Warfarin plus Aspirin, Aspirin Only | Medstar Health Research Institute | Aortic Stenosis | 07/23 | 07/23 | | |
CAMEO, NCT04076813: Cangrelor in Acute Myocardial Infarction: Effectiveness and Outcomes Registry |
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| Recruiting | N/A | 4000 | US | | Chiesi USA, Inc., Duke University | Myocardial Infarction | 10/24 | 10/24 | | |
| Recruiting | N/A | 418 | Europe, US, RoW | SELUTION SLR™ DEB, Control | M.A. Med Alliance S.A., Iqvia Pty Ltd | Coronary Restenosis | 07/24 | 11/27 | | |
| Recruiting | N/A | 1247 | Europe, Canada, US | Edwards PASCAL System, Transcatheter Mitral Valve repair (TMVr), Abbott Mitraclip System | Edwards Lifesciences | Degenerative Mitral Valve Disease, Mitral Regurgitation, Mitral Insufficiency, Functional Mitral Regurgitation | 01/25 | 04/30 | | |
NCT03002272: Transcatheter Aortic Prosthesis Function: A Long-term Follow-up Study |
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| Recruiting | N/A | 100 | US | TAVR, SAVR | Medstar Health Research Institute | Aortic Valve Replacement | 01/24 | 01/28 | | |
| Recruiting | N/A | 25 | US | J-Valve TF System | JC Medical, Inc. | Aortic Valve Disease, Aortic Valve Insufficiency, Aortic Regurgitation | 03/24 | 06/29 | | |
| Not yet recruiting | N/A | 264 | NA | TAVR-explant, Redo-TAVR, Valve-in-Valve, TAV-in-TAV | Medstar Health Research Institute | Symptomatic Patients Who Have Had Transcatheter Heart Valve (THV) Failure, Prosthetic Valve Malfunction, Prosthesis Failure | 05/34 | 05/36 | | |
ECLIPSE, NCT03108456: Evaluation of Treatment Strategies for Severe CaLcIfic Coronary Arteries: Orbital Atherectomy vs. Conventional Angioplasty Technique Prior to Implantation of Drug-Eluting StEnts: The Trial |
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| Active, not recruiting | N/A | 2005 | US | Orbital Atherectomy, Balloon | Abbott Medical Devices, Cardiovascular Research Foundation, New York | Coronary Artery Disease, Ischemic Heart Disease, Non ST Segment Elevation Myocardial Infarction | 06/24 | 06/25 | | |
NCT05966662: Shockwave C2+ 2Hz Coronary IVL Catheter in Calcified Coronary Arteries (Disrupt CAD DUO) |
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| Recruiting | N/A | 145 | US | IVL with Shockwave C2+ 2Hz Coronary IVL Catheter | Shockwave Medical, Inc. | Coronary Artery Disease, Myocardial Infarction | 12/24 | 11/25 | | |
| Recruiting | N/A | 910 | US | PCI with SELUTION SLR DCB, PCI with FDA approved "-limus" DES | M.A. Med Alliance S.A. | Coronary Artery Disease | 08/25 | 08/29 | | |
| Recruiting | N/A | 15 | US | AltaValve | 4C Medical Technologies, Inc. | Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Incompetence, Mitral Valve Regurgitation, Mitral Incompetence | 09/25 | 09/25 | | |
| Recruiting | N/A | 650 | Europe, Canada, Japan, US, RoW | Medtronic Evolut PRO+ TAVR System, or Evolut FX TAVR System, and guideline-directed management and therapy (GDMT) | Medtronic Cardiovascular | Moderate Aortic Valve Stenosis | 02/26 | 12/34 | | |
APOLLO, NCT03242642: Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation. |
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| Recruiting | N/A | 1056 | Europe, Canada, US | Medtronic Intrepid Transcatheter Mitral Valve Replacement System (TMVR) | Medtronic Cardiovascular | Mitral Valve Regurgitation | 10/26 | 09/36 | | |
| Recruiting | N/A | 1000 | Canada, US | | Medstar Health Research Institute | Mitral Valve Disease | 02/27 | 02/27 | | |
| Recruiting | N/A | 1000 | US | Outcomes for Patients with CMD | Medstar Health Research Institute | Coronary Microvascular Dysfunction | 01/33 | 01/33 | | |
| Chawla, Atul |
APOLLO, NCT03242642: Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation. |
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| Recruiting | N/A | 1056 | Europe, Canada, US | Medtronic Intrepid Transcatheter Mitral Valve Replacement System (TMVR) | Medtronic Cardiovascular | Mitral Valve Regurgitation | 10/26 | 09/36 | | |
| Recruiting | N/A | 1000 | Canada, US | | Medstar Health Research Institute | Mitral Valve Disease | 02/27 | 02/27 | | |
| Hoff, Steven |
| Recruiting | N/A | 142 | Europe, US | AtriCure ISOLATOR Synergy Surgical Ablation System | AtriCure, Inc. | Inappropriate Sinus Tachycardia | 06/26 | 06/27 | | |
| Recruiting | N/A | 6500 | Europe, Canada, US | AtriClip LAA Exclusion System | AtriCure, Inc., Population Health Research Institute | Ischemic Stroke, Systemic Embolism | 12/31 | 04/32 | | |
| Cobb, Jessica |
| Recruiting | 3 | 1000 | US, RoW | Cold Stored Platelets, Room Temperature Platelets | Philip Spinella, University of Utah, University of Minnesota, Washington University School of Medicine, United States Department of Defense, University of Pittsburgh | Acute Blood Loss | 01/25 | 01/25 | | |
| Recruiting | 2/3 | 200 | US | Human platelets | Cellphire Therapeutics, Inc., U.S. Army Medical Research and Development Command | Cardiac Surgery | 01/25 | 02/25 | | |
| Active, not recruiting | N/A | 30 | US | penetrating atherosclerotic ulcer, aorta branch cardiovascular implant, Relay Branch System, system, endovascular graft, aortic aneurysm treatment | Bolton Medical | Thoracic Aorta Aneurysm, Aneurysm, Ruptured, Aortic Aneurysm | 09/23 | 08/28 | | |
| Recruiting | N/A | 93 | US | AMDS | Artivion Inc., Syneos Health | Acute Aortic Dissection | 03/24 | 03/28 | | |
SUMMIT, NCT03433274: Clinical Trial to Evaluate the Safety and Effectiveness of Using the Tendyne Transcatheter Mitral Valve System for the Treatment of Symptomatic Mitral Regurgitation |
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| Recruiting | N/A | 958 | Canada, US | Tendyne Mitral Valve System, MitraClip System | Abbott Medical Devices | Mitral Regurgitation, Mitral Insufficiency, Mitral Valve Insufficiency, Cardiovascular Diseases, Valve Disease, Heart, Heart Valve Diseases, Functional Mitral Regurgitation, Degenerative Mitral Valve Disease | 06/24 | 06/28 | | |
| Recruiting | N/A | 75 | US | Experimental: Preserving of Donor Lungs | University of Florida | To Compare Lung Transplant Outcomes Between Study Patients and Standard Patients Who Have Already Undergone Lung Transplantation by Conventional Procedures, Lung Transplant | 07/24 | 07/24 | | |
| Recruiting | N/A | 142 | Europe, US | AtriCure ISOLATOR Synergy Surgical Ablation System | AtriCure, Inc. | Inappropriate Sinus Tachycardia | 06/26 | 06/27 | | |
| Suspended | N/A | 50 | US | Subjects previously implanted with INSPIRIS RESILIA Model 11500A and are undergoing planned valve-in-valve treatment. | Edwards Lifesciences | Aortic Valve Replacement | 12/30 | 01/31 | | |
| Recruiting | N/A | 6500 | Europe, Canada, US | AtriClip LAA Exclusion System | AtriCure, Inc., Population Health Research Institute | Ischemic Stroke, Systemic Embolism | 12/31 | 04/32 | | |
| McAllister, David |
DTU-STEMI, NCT03947619: Primary Unloading and Delayed Reperfusion in ST-Elevation Myocardial Infarction: The STEMI-DTU Trial |
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| Recruiting | N/A | 668 | Europe, Canada, US | Impella CP® placement prior to reperfusion with Primary PCI | Abiomed Inc. | ST Elevation (STEMI) Myocardial Infarction of Anterior Wall | 11/24 | 10/30 | | |
| Jenson, Bart |
APOLLO, NCT03242642: Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation. |
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| Recruiting | N/A | 1056 | Europe, Canada, US | Medtronic Intrepid Transcatheter Mitral Valve Replacement System (TMVR) | Medtronic Cardiovascular | Mitral Valve Regurgitation | 10/26 | 09/36 | | |
| Vallabhajosyula, Prashanth |
| Recruiting | N/A | 93 | US | AMDS | Artivion Inc., Syneos Health | Acute Aortic Dissection | 03/24 | 03/28 | | |
APOLLO, NCT03242642: Transcatheter Mitral Valve Replacement With the Medtronic Intrepid™ TMVR System in Patients With Severe Symptomatic Mitral Regurgitation. |
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| Recruiting | N/A | 1056 | Europe, Canada, US | Medtronic Intrepid Transcatheter Mitral Valve Replacement System (TMVR) | Medtronic Cardiovascular | Mitral Valve Regurgitation | 10/26 | 09/36 | | |
| Tuttle, Kendra |
| Recruiting | N/A | 1000 | Canada, US | | Medstar Health Research Institute | Mitral Valve Disease | 02/27 | 02/27 | | |
| Ishida, Yuichi |
| Recruiting | N/A | 6500 | Europe, Canada, US | AtriClip LAA Exclusion System | AtriCure, Inc., Population Health Research Institute | Ischemic Stroke, Systemic Embolism | 12/31 | 04/32 | | |
| Garner, Cayla |
| Active, not recruiting | 3 | 125 | Canada, US | Autologous cell therapy, Sham | BioCardia, Inc. | Heart Failure, Systolic | 12/24 | 12/26 | | |
| Recruiting | N/A | 1500 | US | Cardiac Contractility Modulation Therapy via OPTIMIZER™ Smart Mini System, CCM Group (CCM ON), OPTIMIZER™ Smart Mini System, Sham Group (CCM OFF) | Impulse Dynamics | Heart Failure, Heart Failure With Preserved Ejection Fraction, Heart Failure With Mid Range Ejection Fraction, Heart Failure With Moderately Reduced Ejection Fraction, Diastolic Heart Failure | 02/25 | 02/26 | | |
| Recruiting | N/A | 6500 | Europe, Canada, US | AtriClip LAA Exclusion System | AtriCure, Inc., Population Health Research Institute | Ischemic Stroke, Systemic Embolism | 12/31 | 04/32 | | |
| Beaver, Tom |
| Recruiting | N/A | 6500 | Europe, Canada, US | AtriClip LAA Exclusion System | AtriCure, Inc., Population Health Research Institute | Ischemic Stroke, Systemic Embolism | 12/31 | 04/32 | | |
| Alfonso, Yanet |
| Recruiting | N/A | 6500 | Europe, Canada, US | AtriClip LAA Exclusion System | AtriCure, Inc., Population Health Research Institute | Ischemic Stroke, Systemic Embolism | 12/31 | 04/32 | | |
