Wake Forest Baptist Health
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 28 Trials 
48 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Miller, Scott
NCT06383390: The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Kidney Outcomes in Adults Living With Obesity (TRIUMPH-Outcomes)

Recruiting
3
10000
Europe, Canada, US, RoW
Retatrutide, LY3437943, Placebo
Eli Lilly and Company
Atherosclerotic Cardiovascular Disease (ASCVD), Chronic Kidney Disease (CKD)
02/29
02/29
NCT05440643: Peanut Sublingual Immunotherapy (SLIT)-Tablet for Treatment of Peanut Allergy

Recruiting
1/2
192
Canada, US
Peanut SLIT-tablet, Placebo
ALK-Abelló A/S, Parexel
Peanut Allergy
01/26
02/26
BA3011-001, NCT03425279: CAB-AXL-ADC Safety and Efficacy Study in Adult and Adolescent Patients with Sarcoma

Active, not recruiting
1/2
300
US, RoW
CAB-AXL-ADC, PD-1 inhibitor
BioAtla, Inc.
Undifferentiated Pleomorphic Sarcoma, Myxofibrosarcoma
01/25
01/25
Craft, Suzanne
MAP, NCT04098666: Metformin in Alzheimer's Dementia Prevention

Active, not recruiting
2/3
326
US
Placebo oral tablet, Placebo, extended release metformin, Metformin
Columbia University, Johns Hopkins University, National Institute on Aging (NIA), University of Rochester, University of Iowa, Boston University, Wake Forest University, Rush University, Pennington Biomedical Research Center, University of Miami, Emory University, Georgetown University, NYU Langone Health, University of California, Berkeley, The University of Texas Health Science Center at San Antonio, University of Washington, State University of New York - Upstate Medical University, University of Texas Southwestern Medical Center, University at Buffalo, University of Cincinnati, Eastern Virginia Medical School, Medical College of Wisconsin, University of Kansas Medical Center, University of New Mexico, Stanford University, University of California, Irvine, Cornell University
Mild Cognitive Impairment
04/26
04/27
NCT03857321: Study of Nasal Insulin to Fight Forgetfulness - Device Study

Active, not recruiting
2
30
US
Insulin, Humulin® R U-100, Placebo, placebo to Humulin® R U-100, Sterile saline, intranasal nebulizer-like device
Wake Forest University Health Sciences
Mild Cognitive Impairment, Cognitive Impairment
08/25
08/25
NCT04199767: SNIFF Multi-Device Study 2

Suspended
2
30
US
20 IU Humulin® R U-100 (NDC: 0002-8215, Eli Lilly & Company), Humulin® R U-100, 40 IU Humulin® R U-100 (NDC: 0002-8215, Eli Lilly & Company)
Wake Forest University Health Sciences
Mild Cognitive Impairment, Cognitive Impairment
10/26
10/27
NCT05081219: SNIFF - Combo INI+EMPA Trial

Completed
2
30
US
Insulin (Humulin® R U-100), Empagliflozin 10 MG, Aptar Pharma CPS Intranasal Delivery Device, Placebo (Insulin Diluent), Placebo (Capsules)
Wake Forest University Health Sciences
Mild Cognitive Impairment, Cognitive Impairment, Alzheimer Disease
09/24
09/24
SToMP-AD, NCT04685590: Senolytic Therapy to Modulate the Progression of Alzheimer's Disease () Study

Active, not recruiting
2
48
Europe, US
Dasatinib + Quercetin, Placebo Capsules
Washington University School of Medicine, The University of Texas Health Science Center at San Antonio, Wake Forest University Health Sciences
Alzheimer Disease, Early Onset, Mild Cognitive Impairment
01/28
01/29
START, NCT05531656: A Study to Evaluate the Safety and Efficacy of CT1812 in Early Alzheimer's Disease

Recruiting
2
540
US
CT1812, Study Drug Active, Placebo, Matching Placebo
Cognition Therapeutics, National Institute on Aging (NIA), Alzheimer's Clinical Trials Consortium
Early Alzheimer's Disease
04/27
04/27
NCT05006599: SNIFF - 3-Week Aptar CPS Device

Not yet recruiting
2
40
NA
Insulin (Humulin® R U-100), Placebo, Insulin Diluent, Aptar Pharma CPS Intranasal Delivery Device
Wake Forest University Health Sciences
Mild Cognitive Impairment, Cognitive Impairment, Alzheimer Disease, Early Onset
05/29
05/31
AcAc PET, NCT03130036: Biodistribution of [11C]Acetoacetate/[18F]Fluorodeoxyglucose in Subjects With Risk Factors for Alzheimer's Disease

Completed
N/A
42
US
[11C]Acetoacetate[18F]Fluorodeoxyglucose positron emission tomography scan
Wake Forest University Health Sciences
Mild Cognitive Impairment
06/24
06/24
TRC-PAD, NCT04004767: Program: In-Clinic Trial-Ready Cohort

Completed
N/A
220
US
University of Southern California, National Institute on Aging (NIA), Alzheimer's Therapeutic Research Institute, Alzheimer's Clinical Trials Consortium, Brigham and Women's Hospital, Cleveland Clinic Lou Ruvo Center for Brain Health
Preclinical Alzheimer's Disease, Prodromal Alzheimer's Disease, Alzheimer Disease, Dementia
04/24
04/24
NCT03089827: Biodistribution of [11C]PIB in Patients With Risk Factors for Alzheimer's Disease

Enrolling by invitation
N/A
800
US
Wake Forest University Health Sciences
Alzheimer Disease, Mild Cognitive Impairment
04/30
04/31
BEAT-AD, NCT03472664: Brain Energy for Amyloid Transformation in Alzheimer's Disease Study

Recruiting
N/A
120
US
low carbohydrate/high fat diet, low fat/high carbohydrate diet
Wake Forest University Health Sciences, National Institute on Aging (NIA)
Alzheimer Disease, Mild Cognitive Impairment
04/25
04/26
Baker, Laura
POINTER, NCT03688126: U.S. Study to Protect Brain Health Through Lifestyle Intervention to Reduce Risk

Active, not recruiting
N/A
2000
US
Self-Guided Lifestyle Intervention, Self-Guided, Structured Lifestyle Intervention
Wake Forest University Health Sciences, Alzheimer's Association
Alzheimer Disease
07/25
07/25
Kitzman, Dalane W
Met-PEFpilot, NCT05093959: Metformin for Older Patients With Heart Failure With Preserved Ejection Fraction

Recruiting
2
80
US
Metformin, metformin XR, Placebo
Wake Forest University Health Sciences, University of South Florida, National Institute on Aging (NIA)
Heart Failure With Preserved Ejection Fraction
12/25
12/25
NCT06517186: Myocardial Mechanisms in Heart Failure With Preserved Ejection Fraction

Recruiting
N/A
180
US
Northwestern University, National Heart, Lung, and Blood Institute (NHLBI), Massachusetts General Hospital, Brigham and Women's Hospital, Mayo Clinic, Wake Forest University Health Sciences, University of Pennsylvania
Heart Failure, Heart Failure With Preserved Ejection Fraction
06/26
06/26
NCT05873634: HeartShare: Combining Omics, Deep Phenotyping, and Electronic Health Records for Heart Failure Subtypes and Treatment Targets

Recruiting
N/A
1000
US
Northwestern University, National Heart, Lung, and Blood Institute (NHLBI), Massachusetts General Hospital, Brigham and Women's Hospital, Mayo Clinic, University of California, Davis, Wake Forest University Health Sciences, University of Pennsylvania
Heart Failure, Heart Failure with Preserved Ejection Fraction
06/26
06/26
REHAB-HFpEF, NCT05525663: Physical Rehabilitation for Older Patients With Acute Heart Failure With Preserved Ejection Fraction

Recruiting
N/A
880
US
Rehabilitation Intervention
Wake Forest University Health Sciences, National Institute on Aging (NIA)
Heart Failure With Preserved Ejection Fraction
11/27
01/28
Kritchevsky, Stephen B
NCT06819254: Pilot Study of Fisetin to Improve Fatigue Among Older Adult Cancer Survivors

Not yet recruiting
4
60
US
Fisetin followed by Placebo, Placebo followed by Fisetin
Wake Forest University Health Sciences, The Ambrose Monell Foundation
Fatigue
12/26
12/26
SYNERGY, NCT03430648: Is Tau Protein Linked to Mobility Function?

Completed
N/A
37
US
Wake Forest University Health Sciences, National Institute on Aging (NIA)
Alzheimer Disease, Physical Activity
09/21
09/21
B-NET, NCT03430427: Brain Networks and Mobility Function:

Completed
N/A
192
US
Wake Forest University Health Sciences, National Institute on Aging (NIA)
Central Nervous System, White Matter Disease
07/23
07/23
HALLO-P, NCT05424042: Health, Aging and Later-Life Outcomes

Completed
N/A
90
US
In-Person Caloric Restriction, Remote Caloric Restriction, Time-restricted
Wake Forest University Health Sciences, National Institute on Aging (NIA)
Aging
07/24
07/24
Eisenach, James C
NCT05179421: Dose Ranging Study of Intravenous Oxytocin for Analgesia to Heat Pain

Completed
2
25
US
Low dose oxytocin, Pitocin, High dose oxytocin
Wake Forest University Health Sciences
Healthy Volunteer Study
02/23
02/23
NCT04431206: Generate a Pharmacodynamic Model of Oxytocin for Peripheral Analgesic Effects

Recruiting
2
38
US
Oxytocin, Pitocin
Wake Forest University Health Sciences
Osteoarthritis, Knee
02/26
02/26
NCT04433741: Apply the PD Model of Peripheral Oxytocin Action to a Multimodal Stimulus

Withdrawn
2
30
US
Oxytocin, Pitocin, Placebo
Wake Forest University Health Sciences
Pain, Chronic
12/25
12/25
NCT05929339: Defining a PK and PD Model for Peripheral Analgesia After IV Oxytocin

Completed
2
25
US
Oxytocin, Pitocin
Wake Forest University Health Sciences, National Institute of Neurological Disorders and Stroke (NINDS)
Acute Pain, Chronic Pain, Healthy Volunteer
10/24
10/24
NCT06651476: A Randomized Controlled Trial to Test the Effects Oxytocin and Vibration Have on Heat Pain Threshold After UV-B Burn

Recruiting
2
36
US
oxytocin, placebo
Wake Forest University Health Sciences, National Institute of Neurological Disorders and Stroke (NINDS)
Sunburn
08/25
08/25
NCT04427709: Generate and Test the Reliability of a PD Model of OXT on Pupillary Hippus as a Measure of CNS Activity

Recruiting
2
38
US
Oxytocin, Pitocin, Placebo
Wake Forest University Health Sciences, National Institute of Neurological Disorders and Stroke (NINDS)
Chronic Pain, Osteoarthritis, Knee
01/26
01/26
NCT04435704: Validate a Pharmacodynamic Model of Oxytocin for Peripheral Analgesic Effects

Withdrawn
2
26
US
Oxytocin, Pitocin
Wake Forest University Health Sciences
Osteoarthritis, Knee
01/27
01/27
NCT05672667: A Pharmacokinetic Study of Intravenous and Intranasal Oxytocin in Healthy Subjects

Completed
1
25
US
intravenous oxytocin, Pitocin, intranasal oxytocin, TNX-1900
Wake Forest University Health Sciences, National Institute of Neurological Disorders and Stroke (NINDS)
Healthy Volunteer Study
11/23
11/23
NCT02628314: Reliability of Pupil Response to Acute Pain

Recruiting
N/A
80
US
Wake Forest University Health Sciences
Pain, Osteoarthritis
12/25
12/25
Ard, Jamy D
LEAP, NCT05176626: Long-term Effectiveness of the Antiobesity Medication Phentermine

Active, not recruiting
4
870
US
Online Lifestyle Behavioral Therapy, Phentermine Hydrochloride 8 MG, Lomaira
Wake Forest University Health Sciences, Johns Hopkins University, Kaiser Permanente, HealthPartners Institute, The University of Texas Health Science Center, Houston, Biomedical Research Institute of New Mexico, WW International Inc, KVK-Tech, Inc., National Heart, Lung, and Blood Institute (NHLBI)
Obesity, Obesity; Drug, Lifestyle, Healthy
12/26
12/26
ACHIEVE-3, NCT06045221: A Study of Orforglipron (LY3502970) Compared With Semaglutide in Participants With Type 2 Diabetes Inadequately Controlled With Metformin

Active, not recruiting
3
1576
Japan, US, RoW
Orforglipron, LY3502970, Semaglutide
Eli Lilly and Company
Type 2 Diabetes
09/25
09/25
WE RISE U01, NCT04922333: Bisphosphonate Use to Mitigate Bone Loss Secondary to Bariatric Surgery

Recruiting
3
200
US
Risedronate, Actonel, Atelvia, Placebo
Wake Forest University Health Sciences, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Bone Loss
04/28
04/28
NCT04994769: The Effect of Extended Use of the EPITOMEE CAPSULE (ELECT)

Completed
N/A
33
US
Epitomee Capsule, The MODEL IBT Program
Epitomee medical
Overweight and Obesity
12/23
03/24
NCT05348395: Monocyte Priming When Consuming a Western Diet

Completed
N/A
8
US
Experimental diet
Wake Forest University Health Sciences, National Institutes of Health (NIH), National Heart, Lung, and Blood Institute (NHLBI)
Heart Diseases
10/24
10/24
NCT04663061: Diabetes Data-Assisted Remission Trial (DDART)

Completed
N/A
65
US
Medical weight loss, Diabetes education, Continuous glucose monitoring
Wake Forest University Health Sciences, UnitedHealth Group
Type 2 Diabetes, Obesity
11/24
11/24
VITAL-CGM, NCT05935514: Improving Glycemic Control Using a Virtual Weight Control Program and Continuous Glucose Monitoring

Active, not recruiting
N/A
152
US
WW Intervention, Usual Care
Pennington Biomedical Research Center, WW International Inc
Diabetes Mellitus, Type 2 Diabetes, Obesity
11/25
11/25
Evans, John A
NCT05065450: Amygdala Memory Enhancement

Recruiting
N/A
90
US
Intracranial Stimulation, Device: ACTIVE basal lateral amygdala electrical stimulation (Active-BLAES), Device: SHAM basal lateral amygdala electrical stimulation (Sham-BLAES)
Washington University School of Medicine
Brain Diseases, Epilepsy, Memory Disorders, Traumatic Brain Injury, Cognitive Impairment, Post Traumatic Stress Disorder
11/26
11/27
Shaltout, Hossam A
PEPC3, NCT04026776: Uric Acid, Klotho and Salt Sensitivity in Young Adults Born Preterm

Recruiting
1
165
US
Allopurinol, Zyloprim, Dietary Intervention
Wake Forest University Health Sciences, National Heart, Lung, and Blood Institute (NHLBI)
Salt; Excess, Blood Pressure Disorders
06/25
06/25
Mintz, Akiva
NCT05109728: A Dose Finding Study of [177Lu]Lu-DOTA-TATE in Newly Diagnosed Glioblastoma in Combination With Standard of Care and in Recurrent Glioblastoma as a Single Agent.

Recruiting
1
60
Europe, US
[177Lu]Lu-DOTA-TATE, Lutathera, Lutetium (177Lu)oxodotreotide, Lutetium Lu 177dotatate, [68Ga]Ga-DOTA-TATE, Temozolomide, Radiotherapy
Novartis Pharmaceuticals
Glioblastoma
03/27
04/28
NCT04575727: Exploratory Evaluation of [11C]MPC6827

Recruiting
1
40
US
[11C]MPC6827, [11C]MPC
Columbia University
Neurodegenerative Diseases, Alzheimer Disease, Amyotrophic Lateral Sclerosis
09/24
09/25
NCT03705819: Exploratory Evaluation of [11C]-NOP46

Recruiting
1
40
US
[11C]-NOP46, PET/CT scan
Akiva Mintz
Chronic Pain
03/25
03/25
Parker-Autry, Candace Y
NCT05723601: Preference of Women With Recurrent Urinary Tract Infection for Vaginal Estradiol Tablet vs Cream

Recruiting
4
24
US
Estradiol vaginal cream, Estradiol Vaginal Tablet
Wake Forest University Health Sciences
Recurrent Urinary Tract Infection
01/26
01/26
NCT03333811: Sexual Function After Vaginal Repair With Perineorrhaphy

Not yet recruiting
N/A
65
NA
Perineorrhaphy, Surgical repair of vaginal prolapse
Wake Forest University Health Sciences
Vaginal Prolapse
02/18
06/18
RadPFD, NCT04623515: Radiation Therapy on Pelvic Floor Disorders in Women

Terminated
N/A
49
US
REDCap Questionnaires
Wake Forest University Health Sciences, National Cancer Institute (NCI)
Colorectal Cancer
04/22
04/22
NCT06335797: Optimization of Postoperative Bowel Habits

Recruiting
N/A
88
US
Senna Tab, Senokot, Dulcolax Suppositories, Bisacodyl Suppositories
Wake Forest University Health Sciences
Constipation
08/25
02/26
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
Miller, Scott
NCT06383390: The Effect of Retatrutide Once Weekly on Cardiovascular Outcomes and Kidney Outcomes in Adults Living With Obesity (TRIUMPH-Outcomes)

Recruiting
3
10000
Europe, Canada, US, RoW
Retatrutide, LY3437943, Placebo
Eli Lilly and Company
Atherosclerotic Cardiovascular Disease (ASCVD), Chronic Kidney Disease (CKD)
02/29
02/29
NCT05440643: Peanut Sublingual Immunotherapy (SLIT)-Tablet for Treatment of Peanut Allergy

Recruiting
1/2
192
Canada, US
Peanut SLIT-tablet, Placebo
ALK-Abelló A/S, Parexel
Peanut Allergy
01/26
02/26
BA3011-001, NCT03425279: CAB-AXL-ADC Safety and Efficacy Study in Adult and Adolescent Patients with Sarcoma

Active, not recruiting
1/2
300
US, RoW
CAB-AXL-ADC, PD-1 inhibitor
BioAtla, Inc.
Undifferentiated Pleomorphic Sarcoma, Myxofibrosarcoma
01/25
01/25
Craft, Suzanne
MAP, NCT04098666: Metformin in Alzheimer's Dementia Prevention

Active, not recruiting
2/3
326
US
Placebo oral tablet, Placebo, extended release metformin, Metformin
Columbia University, Johns Hopkins University, National Institute on Aging (NIA), University of Rochester, University of Iowa, Boston University, Wake Forest University, Rush University, Pennington Biomedical Research Center, University of Miami, Emory University, Georgetown University, NYU Langone Health, University of California, Berkeley, The University of Texas Health Science Center at San Antonio, University of Washington, State University of New York - Upstate Medical University, University of Texas Southwestern Medical Center, University at Buffalo, University of Cincinnati, Eastern Virginia Medical School, Medical College of Wisconsin, University of Kansas Medical Center, University of New Mexico, Stanford University, University of California, Irvine, Cornell University
Mild Cognitive Impairment
04/26
04/27
NCT03857321: Study of Nasal Insulin to Fight Forgetfulness - Device Study

Active, not recruiting
2
30
US
Insulin, Humulin® R U-100, Placebo, placebo to Humulin® R U-100, Sterile saline, intranasal nebulizer-like device
Wake Forest University Health Sciences
Mild Cognitive Impairment, Cognitive Impairment
08/25
08/25
NCT04199767: SNIFF Multi-Device Study 2

Suspended
2
30
US
20 IU Humulin® R U-100 (NDC: 0002-8215, Eli Lilly & Company), Humulin® R U-100, 40 IU Humulin® R U-100 (NDC: 0002-8215, Eli Lilly & Company)
Wake Forest University Health Sciences
Mild Cognitive Impairment, Cognitive Impairment
10/26
10/27
NCT05081219: SNIFF - Combo INI+EMPA Trial

Completed
2
30
US
Insulin (Humulin® R U-100), Empagliflozin 10 MG, Aptar Pharma CPS Intranasal Delivery Device, Placebo (Insulin Diluent), Placebo (Capsules)
Wake Forest University Health Sciences
Mild Cognitive Impairment, Cognitive Impairment, Alzheimer Disease
09/24
09/24
SToMP-AD, NCT04685590: Senolytic Therapy to Modulate the Progression of Alzheimer's Disease () Study

Active, not recruiting
2
48
Europe, US
Dasatinib + Quercetin, Placebo Capsules
Washington University School of Medicine, The University of Texas Health Science Center at San Antonio, Wake Forest University Health Sciences
Alzheimer Disease, Early Onset, Mild Cognitive Impairment
01/28
01/29
START, NCT05531656: A Study to Evaluate the Safety and Efficacy of CT1812 in Early Alzheimer's Disease

Recruiting
2
540
US
CT1812, Study Drug Active, Placebo, Matching Placebo
Cognition Therapeutics, National Institute on Aging (NIA), Alzheimer's Clinical Trials Consortium
Early Alzheimer's Disease
04/27
04/27
NCT05006599: SNIFF - 3-Week Aptar CPS Device

Not yet recruiting
2
40
NA
Insulin (Humulin® R U-100), Placebo, Insulin Diluent, Aptar Pharma CPS Intranasal Delivery Device
Wake Forest University Health Sciences
Mild Cognitive Impairment, Cognitive Impairment, Alzheimer Disease, Early Onset
05/29
05/31
AcAc PET, NCT03130036: Biodistribution of [11C]Acetoacetate/[18F]Fluorodeoxyglucose in Subjects With Risk Factors for Alzheimer's Disease

Completed
N/A
42
US
[11C]Acetoacetate[18F]Fluorodeoxyglucose positron emission tomography scan
Wake Forest University Health Sciences
Mild Cognitive Impairment
06/24
06/24
TRC-PAD, NCT04004767: Program: In-Clinic Trial-Ready Cohort

Completed
N/A
220
US
University of Southern California, National Institute on Aging (NIA), Alzheimer's Therapeutic Research Institute, Alzheimer's Clinical Trials Consortium, Brigham and Women's Hospital, Cleveland Clinic Lou Ruvo Center for Brain Health
Preclinical Alzheimer's Disease, Prodromal Alzheimer's Disease, Alzheimer Disease, Dementia
04/24
04/24
NCT03089827: Biodistribution of [11C]PIB in Patients With Risk Factors for Alzheimer's Disease

Enrolling by invitation
N/A
800
US
Wake Forest University Health Sciences
Alzheimer Disease, Mild Cognitive Impairment
04/30
04/31
BEAT-AD, NCT03472664: Brain Energy for Amyloid Transformation in Alzheimer's Disease Study

Recruiting
N/A
120
US
low carbohydrate/high fat diet, low fat/high carbohydrate diet
Wake Forest University Health Sciences, National Institute on Aging (NIA)
Alzheimer Disease, Mild Cognitive Impairment
04/25
04/26
Baker, Laura
POINTER, NCT03688126: U.S. Study to Protect Brain Health Through Lifestyle Intervention to Reduce Risk

Active, not recruiting
N/A
2000
US
Self-Guided Lifestyle Intervention, Self-Guided, Structured Lifestyle Intervention
Wake Forest University Health Sciences, Alzheimer's Association
Alzheimer Disease
07/25
07/25
Kitzman, Dalane W
Met-PEFpilot, NCT05093959: Metformin for Older Patients With Heart Failure With Preserved Ejection Fraction

Recruiting
2
80
US
Metformin, metformin XR, Placebo
Wake Forest University Health Sciences, University of South Florida, National Institute on Aging (NIA)
Heart Failure With Preserved Ejection Fraction
12/25
12/25
NCT06517186: Myocardial Mechanisms in Heart Failure With Preserved Ejection Fraction

Recruiting
N/A
180
US
Northwestern University, National Heart, Lung, and Blood Institute (NHLBI), Massachusetts General Hospital, Brigham and Women's Hospital, Mayo Clinic, Wake Forest University Health Sciences, University of Pennsylvania
Heart Failure, Heart Failure With Preserved Ejection Fraction
06/26
06/26
NCT05873634: HeartShare: Combining Omics, Deep Phenotyping, and Electronic Health Records for Heart Failure Subtypes and Treatment Targets

Recruiting
N/A
1000
US
Northwestern University, National Heart, Lung, and Blood Institute (NHLBI), Massachusetts General Hospital, Brigham and Women's Hospital, Mayo Clinic, University of California, Davis, Wake Forest University Health Sciences, University of Pennsylvania
Heart Failure, Heart Failure with Preserved Ejection Fraction
06/26
06/26
REHAB-HFpEF, NCT05525663: Physical Rehabilitation for Older Patients With Acute Heart Failure With Preserved Ejection Fraction

Recruiting
N/A
880
US
Rehabilitation Intervention
Wake Forest University Health Sciences, National Institute on Aging (NIA)
Heart Failure With Preserved Ejection Fraction
11/27
01/28
Kritchevsky, Stephen B
NCT06819254: Pilot Study of Fisetin to Improve Fatigue Among Older Adult Cancer Survivors

Not yet recruiting
4
60
US
Fisetin followed by Placebo, Placebo followed by Fisetin
Wake Forest University Health Sciences, The Ambrose Monell Foundation
Fatigue
12/26
12/26
SYNERGY, NCT03430648: Is Tau Protein Linked to Mobility Function?

Completed
N/A
37
US
Wake Forest University Health Sciences, National Institute on Aging (NIA)
Alzheimer Disease, Physical Activity
09/21
09/21
B-NET, NCT03430427: Brain Networks and Mobility Function:

Completed
N/A
192
US
Wake Forest University Health Sciences, National Institute on Aging (NIA)
Central Nervous System, White Matter Disease
07/23
07/23
HALLO-P, NCT05424042: Health, Aging and Later-Life Outcomes

Completed
N/A
90
US
In-Person Caloric Restriction, Remote Caloric Restriction, Time-restricted
Wake Forest University Health Sciences, National Institute on Aging (NIA)
Aging
07/24
07/24
Eisenach, James C
NCT05179421: Dose Ranging Study of Intravenous Oxytocin for Analgesia to Heat Pain

Completed
2
25
US
Low dose oxytocin, Pitocin, High dose oxytocin
Wake Forest University Health Sciences
Healthy Volunteer Study
02/23
02/23
NCT04431206: Generate a Pharmacodynamic Model of Oxytocin for Peripheral Analgesic Effects

Recruiting
2
38
US
Oxytocin, Pitocin
Wake Forest University Health Sciences
Osteoarthritis, Knee
02/26
02/26
NCT04433741: Apply the PD Model of Peripheral Oxytocin Action to a Multimodal Stimulus

Withdrawn
2
30
US
Oxytocin, Pitocin, Placebo
Wake Forest University Health Sciences
Pain, Chronic
12/25
12/25
NCT05929339: Defining a PK and PD Model for Peripheral Analgesia After IV Oxytocin

Completed
2
25
US
Oxytocin, Pitocin
Wake Forest University Health Sciences, National Institute of Neurological Disorders and Stroke (NINDS)
Acute Pain, Chronic Pain, Healthy Volunteer
10/24
10/24
NCT06651476: A Randomized Controlled Trial to Test the Effects Oxytocin and Vibration Have on Heat Pain Threshold After UV-B Burn

Recruiting
2
36
US
oxytocin, placebo
Wake Forest University Health Sciences, National Institute of Neurological Disorders and Stroke (NINDS)
Sunburn
08/25
08/25
NCT04427709: Generate and Test the Reliability of a PD Model of OXT on Pupillary Hippus as a Measure of CNS Activity

Recruiting
2
38
US
Oxytocin, Pitocin, Placebo
Wake Forest University Health Sciences, National Institute of Neurological Disorders and Stroke (NINDS)
Chronic Pain, Osteoarthritis, Knee
01/26
01/26
NCT04435704: Validate a Pharmacodynamic Model of Oxytocin for Peripheral Analgesic Effects

Withdrawn
2
26
US
Oxytocin, Pitocin
Wake Forest University Health Sciences
Osteoarthritis, Knee
01/27
01/27
NCT05672667: A Pharmacokinetic Study of Intravenous and Intranasal Oxytocin in Healthy Subjects

Completed
1
25
US
intravenous oxytocin, Pitocin, intranasal oxytocin, TNX-1900
Wake Forest University Health Sciences, National Institute of Neurological Disorders and Stroke (NINDS)
Healthy Volunteer Study
11/23
11/23
NCT02628314: Reliability of Pupil Response to Acute Pain

Recruiting
N/A
80
US
Wake Forest University Health Sciences
Pain, Osteoarthritis
12/25
12/25
Ard, Jamy D
LEAP, NCT05176626: Long-term Effectiveness of the Antiobesity Medication Phentermine

Active, not recruiting
4
870
US
Online Lifestyle Behavioral Therapy, Phentermine Hydrochloride 8 MG, Lomaira
Wake Forest University Health Sciences, Johns Hopkins University, Kaiser Permanente, HealthPartners Institute, The University of Texas Health Science Center, Houston, Biomedical Research Institute of New Mexico, WW International Inc, KVK-Tech, Inc., National Heart, Lung, and Blood Institute (NHLBI)
Obesity, Obesity; Drug, Lifestyle, Healthy
12/26
12/26
ACHIEVE-3, NCT06045221: A Study of Orforglipron (LY3502970) Compared With Semaglutide in Participants With Type 2 Diabetes Inadequately Controlled With Metformin

Active, not recruiting
3
1576
Japan, US, RoW
Orforglipron, LY3502970, Semaglutide
Eli Lilly and Company
Type 2 Diabetes
09/25
09/25
WE RISE U01, NCT04922333: Bisphosphonate Use to Mitigate Bone Loss Secondary to Bariatric Surgery

Recruiting
3
200
US
Risedronate, Actonel, Atelvia, Placebo
Wake Forest University Health Sciences, National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Bone Loss
04/28
04/28
NCT04994769: The Effect of Extended Use of the EPITOMEE CAPSULE (ELECT)

Completed
N/A
33
US
Epitomee Capsule, The MODEL IBT Program
Epitomee medical
Overweight and Obesity
12/23
03/24
NCT05348395: Monocyte Priming When Consuming a Western Diet

Completed
N/A
8
US
Experimental diet
Wake Forest University Health Sciences, National Institutes of Health (NIH), National Heart, Lung, and Blood Institute (NHLBI)
Heart Diseases
10/24
10/24
NCT04663061: Diabetes Data-Assisted Remission Trial (DDART)

Completed
N/A
65
US
Medical weight loss, Diabetes education, Continuous glucose monitoring
Wake Forest University Health Sciences, UnitedHealth Group
Type 2 Diabetes, Obesity
11/24
11/24
VITAL-CGM, NCT05935514: Improving Glycemic Control Using a Virtual Weight Control Program and Continuous Glucose Monitoring

Active, not recruiting
N/A
152
US
WW Intervention, Usual Care
Pennington Biomedical Research Center, WW International Inc
Diabetes Mellitus, Type 2 Diabetes, Obesity
11/25
11/25
Evans, John A
NCT05065450: Amygdala Memory Enhancement

Recruiting
N/A
90
US
Intracranial Stimulation, Device: ACTIVE basal lateral amygdala electrical stimulation (Active-BLAES), Device: SHAM basal lateral amygdala electrical stimulation (Sham-BLAES)
Washington University School of Medicine
Brain Diseases, Epilepsy, Memory Disorders, Traumatic Brain Injury, Cognitive Impairment, Post Traumatic Stress Disorder
11/26
11/27
Shaltout, Hossam A
PEPC3, NCT04026776: Uric Acid, Klotho and Salt Sensitivity in Young Adults Born Preterm

Recruiting
1
165
US
Allopurinol, Zyloprim, Dietary Intervention
Wake Forest University Health Sciences, National Heart, Lung, and Blood Institute (NHLBI)
Salt; Excess, Blood Pressure Disorders
06/25
06/25
Mintz, Akiva
NCT05109728: A Dose Finding Study of [177Lu]Lu-DOTA-TATE in Newly Diagnosed Glioblastoma in Combination With Standard of Care and in Recurrent Glioblastoma as a Single Agent.

Recruiting
1
60
Europe, US
[177Lu]Lu-DOTA-TATE, Lutathera, Lutetium (177Lu)oxodotreotide, Lutetium Lu 177dotatate, [68Ga]Ga-DOTA-TATE, Temozolomide, Radiotherapy
Novartis Pharmaceuticals
Glioblastoma
03/27
04/28
NCT04575727: Exploratory Evaluation of [11C]MPC6827

Recruiting
1
40
US
[11C]MPC6827, [11C]MPC
Columbia University
Neurodegenerative Diseases, Alzheimer Disease, Amyotrophic Lateral Sclerosis
09/24
09/25
NCT03705819: Exploratory Evaluation of [11C]-NOP46

Recruiting
1
40
US
[11C]-NOP46, PET/CT scan
Akiva Mintz
Chronic Pain
03/25
03/25
Parker-Autry, Candace Y
NCT05723601: Preference of Women With Recurrent Urinary Tract Infection for Vaginal Estradiol Tablet vs Cream

Recruiting
4
24
US
Estradiol vaginal cream, Estradiol Vaginal Tablet
Wake Forest University Health Sciences
Recurrent Urinary Tract Infection
01/26
01/26
NCT03333811: Sexual Function After Vaginal Repair With Perineorrhaphy

Not yet recruiting
N/A
65
NA
Perineorrhaphy, Surgical repair of vaginal prolapse
Wake Forest University Health Sciences
Vaginal Prolapse
02/18
06/18
RadPFD, NCT04623515: Radiation Therapy on Pelvic Floor Disorders in Women

Terminated
N/A
49
US
REDCap Questionnaires
Wake Forest University Health Sciences, National Cancer Institute (NCI)
Colorectal Cancer
04/22
04/22
NCT06335797: Optimization of Postoperative Bowel Habits

Recruiting
N/A
88
US
Senna Tab, Senokot, Dulcolax Suppositories, Bisacodyl Suppositories
Wake Forest University Health Sciences
Constipation
08/25
02/26

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