Fondation Institut Curie
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 14 Trials 
17 Trials

   

 
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
BRIANDET, Claire
HR-NBL2, NCT04221035 / 2019-001068-31: High-Risk Neuroblastoma Study 2 of SIOP-Europa-Neuroblastoma (SIOPEN)

Recruiting
3
800
Europe, RoW
Vincristine, L01CA02, Carboplatin, LO1XA02, Etoposide, L01CB01, Vindesine, L01CA03, Dacarbazine, L01AX04, Ifosfamide, Doxorubicin, L01DB01, Busulfan, L01AB01, Melphalan, L01AA03, Thiotepa, L01AC01, Radiotherapy, Dinutuximab Beta, L01XC16, Cisplatin, L01XA01, Temozolomide 100 MG, Irinotecan, Cyclophosphamid
Gustave Roussy, Cancer Campus, Grand Paris, PHRC, Solving Kids' Cancer Europe, Neuroblastoma UK, , BSPHO, Instituto de Investigación Sanitaria La Fe, Deutsche Krebshilfe
High-Risk Neuroblastoma, Patient With Insufficient Response Chemoimmunotherapy
11/26
11/32
BIOMEDE 2, NCT05476939: Biological Medicine for Diffuse Intrinsic Pontine Glioma (DIPG) Eradication 2.0

Recruiting
3
409
Europe
Everolimus, VOTUBIA, AFINITOR, ONC201, Radiotherapy
Gustave Roussy, Cancer Campus, Grand Paris, Chimerix, Innovative Therapies For Children with Cancer Consortium, Ministry of Health, France
Diffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma, H3 K27M-Mutant
09/28
09/31
SIOP-EP-II, NCT02265770 / 2013-002766-39: An International Clinical Program for the Diagnosis and Treatment of Children With Ependymoma

Recruiting
2/3
536
Europe, RoW
16 weeks of VEC + CDDP, Vincristine, Etoposide, Cyclophosphamide, Cisplatin, VEC + HD-MTX, Methotrexate, Chemotherapy + Valproate, Carboplatin, Valproate, Conformal radiotherapy, VEC, Chemotherapy, conformal radiotherapy +/- boost
Centre Leon Berard
Childhood Ependymoma
06/28
08/31
RETINO2018, NCT04681417 / 2019-005039-94: Ocular Conservative Treatment for Retinoblastoma : Efficacy of the New Management Strategies and Visual Outcome

Recruiting
2/3
225
Europe
Melphalan or Melphalan + Topotecan, Alkeran, Topotecan Accord; Topotecan Hospira chemotherapy, etoposide, carboplatin and vincristine or local ophthalmological treatment without IV chemotherapy, etoposide, carboplatin and vincristine chemotherapy, Carboplatin administered on Day 1, platinum-based chemotherapy, Thermotherapy (local treatment), Thermotherapy after carboplatin administered on Day 1, Cryotherapy (local treatment), Iodine-125 plaques (local treatment), Intravitreal Melphalan chemotherapy injections (local treatment)
Institut Curie, Fondation Rothschild Paris
Retinoblastoma
01/35
01/36
RETINO2011, NCT02866136: Conservative Treatments of Retinoblastoma

Active, not recruiting
2
133
Europe
VP16, carboplatin, etoposide, vepesid, chemotherapy, Melphalan, Alkeran, chemotherapy, VP16, carboplatin, vincristin, etoposide, vepesid, leurocristine, Oncovin, chemotherapy, Carboplatin + laser day 1 (chemothermotherapy), Carbo-laser, platinum-based chemotherapy, Laser (local treatment), Laser diode, cryoapplication (local treatment), I125 radioactive plaques (local treatment), intravitreal Melphalan (local treatment)
Institut Curie, Fondation Rothschild Paris
Retinoblastoma, Children, Retinal Neoplasm
01/23
09/35
NCT02870907 / 2009-016448-38: Adjuvant Treatment in Extensive Unilateral Retinoblastoma Primary Enucleated (RB SFCE 2009)

Recruiting
2
185
Europe
Observation, Low risk group, Etoposide, Intermediate risk sub group 1, Vincristine, Intermediate risk sub group 2, Orbital irradiation, High risk group, Carboplatin, Cyclophosphamide, Thiotepa, Cytapheresis, Peripheral bood stem cell transplantation
Institut Curie
Retinoblastoma
03/30
09/30
NEUROBLU 02, NCT03966651 / 2020-002996-36: A Clinical Study Evaluating the Safety of Peptide Receptor Radionuclide Therapy (PRRT) With 177Lu-DOTA0-Tyr3-Octreotate in Children With Refractory or Recurrent Neuroblastoma Expressing Somatostatin Receptors.

Recruiting
1
18
Europe
PRRT with 177Lu-DOTATATE
Institut Claudius Regaud, Advanced Accelerator Applications
Neuroblastoma
10/25
02/26
NCT03306251: National Cohort of Children Born to HIV-positive Mothers

Recruiting
N/A
5200
Europe, RoW
ANRS, Emerging Infectious Diseases
Mother to Child Transmission of HIV
03/23
03/23
SACHA, NCT04477681: Securing Access to Innovative Molecules in Oncology and Hematology for Children, Adolescents and Young Adults

Recruiting
N/A
1000
Europe
Data collection
Gustave Roussy, Cancer Campus, Grand Paris, Société Française des Cancers de l'Enfant (SFCE)
Pediatric Cancer
04/26
04/27
MICCHADO, NCT03496402: Biological Characterisation of High Risk CHildhood Cancer in Children, Adolescents and Young Adults

Active, not recruiting
N/A
600
Europe
Sampling on blood, bone marrow and cerebrospinal fluid
Institut Curie
Neuroblastoma, Rhabdomyosarcoma, Ewing Sarcoma Family of Tumors, Osteosarcoma, Leukemia, Central Nervous System Tumor
04/27
08/27
BIOPORTAL, NCT05192980: SIOPEN , an International Registry Linked to a Virtual Biobank for Patients with Peripheral Neuroblastic Tumours

Recruiting
N/A
600
Europe
No Intervention NA, Bio-sampling
Institut Curie
Neuroblastoma, Ganglioneuroblastoma, Ganglioneuroma
11/38
11/38
PTB, NCT05660499: Impact of the Development of Pediatric Palliative Care

Recruiting
N/A
40
Europe
University Hospital, Strasbourg, France
Primary Brain Tumor
12/23
12/23
Doz, François
SIOP-EP-II, NCT02265770 / 2013-002766-39: An International Clinical Program for the Diagnosis and Treatment of Children With Ependymoma

Recruiting
2/3
536
Europe, RoW
16 weeks of VEC + CDDP, Vincristine, Etoposide, Cyclophosphamide, Cisplatin, VEC + HD-MTX, Methotrexate, Chemotherapy + Valproate, Carboplatin, Valproate, Conformal radiotherapy, VEC, Chemotherapy, conformal radiotherapy +/- boost
Centre Leon Berard
Childhood Ependymoma
06/28
08/31
MS100070_0087, NCT05081180 / 2020-004397-22: Study of Avelumab in Combination With Lenvatinib for Children With Primary CNS Tumors

Active, not recruiting
1
17
Europe, Canada, RoW
Avelumab, Lenvatinib
EMD Serono Research & Development Institute, Inc., Merck KGaA, Darmstadt, Germany
Central Nervous System Tumors
12/25
12/25
SCOOP, NCT04544995 / 2020-002359-39: Dose Escalation and Cohort Expansion Study of Niraparib and Dostarlimab in Paediatric Participants With Solid Tumors

Recruiting
1
116
Europe, RoW
Niraparib (Tablet for oral suspension), Dostarlimab, Niraparib (Tablet)
GlaxoSmithKline
Neoplasms
10/29
05/30
CervIRM, NCT04174820: Child's Study of the Impact of PF Lesion on Motor Skills, Language, Cognitive Functioning and Social Cognition

Recruiting
N/A
145
Europe
Functional Magnetic Resonance Imaging (fMRI), Speech Therapy Tests, Neuropsychological Tests, Balance and Dexterity Tests
University Hospital, Angers, Assistance Publique - Hôpitaux de Paris, National Cancer Institute, France
Medulloblastoma, Childhood, Healthy Volunteers, Fossa Posterior Tumor, Low-grade Glioma
11/22
11/22
RISP-OTOTOX, NCT06957132: Analysis of Risk Factors for Hearing Loss in Survivors of Cancer Occurred During Childhood, Adolescence or Young Adulthood

Not yet recruiting
N/A
500
Europe
Audiogram, iAudiogram medical device
Gustave Roussy, Cancer Campus, Grand Paris
Ototoxicity, Drug-Induced, Ototoxicity, Radiation-Induced, Pediatric Cancer
04/26
04/26
Trial + Data / EventsStatusPhNRegionInterventionsSponsorConditionsPrimary complStudy compl
BRIANDET, Claire
HR-NBL2, NCT04221035 / 2019-001068-31: High-Risk Neuroblastoma Study 2 of SIOP-Europa-Neuroblastoma (SIOPEN)

Recruiting
3
800
Europe, RoW
Vincristine, L01CA02, Carboplatin, LO1XA02, Etoposide, L01CB01, Vindesine, L01CA03, Dacarbazine, L01AX04, Ifosfamide, Doxorubicin, L01DB01, Busulfan, L01AB01, Melphalan, L01AA03, Thiotepa, L01AC01, Radiotherapy, Dinutuximab Beta, L01XC16, Cisplatin, L01XA01, Temozolomide 100 MG, Irinotecan, Cyclophosphamid
Gustave Roussy, Cancer Campus, Grand Paris, PHRC, Solving Kids' Cancer Europe, Neuroblastoma UK, , BSPHO, Instituto de Investigación Sanitaria La Fe, Deutsche Krebshilfe
High-Risk Neuroblastoma, Patient With Insufficient Response Chemoimmunotherapy
11/26
11/32
BIOMEDE 2, NCT05476939: Biological Medicine for Diffuse Intrinsic Pontine Glioma (DIPG) Eradication 2.0

Recruiting
3
409
Europe
Everolimus, VOTUBIA, AFINITOR, ONC201, Radiotherapy
Gustave Roussy, Cancer Campus, Grand Paris, Chimerix, Innovative Therapies For Children with Cancer Consortium, Ministry of Health, France
Diffuse Intrinsic Pontine Glioma, Diffuse Midline Glioma, H3 K27M-Mutant
09/28
09/31
SIOP-EP-II, NCT02265770 / 2013-002766-39: An International Clinical Program for the Diagnosis and Treatment of Children With Ependymoma

Recruiting
2/3
536
Europe, RoW
16 weeks of VEC + CDDP, Vincristine, Etoposide, Cyclophosphamide, Cisplatin, VEC + HD-MTX, Methotrexate, Chemotherapy + Valproate, Carboplatin, Valproate, Conformal radiotherapy, VEC, Chemotherapy, conformal radiotherapy +/- boost
Centre Leon Berard
Childhood Ependymoma
06/28
08/31
RETINO2018, NCT04681417 / 2019-005039-94: Ocular Conservative Treatment for Retinoblastoma : Efficacy of the New Management Strategies and Visual Outcome

Recruiting
2/3
225
Europe
Melphalan or Melphalan + Topotecan, Alkeran, Topotecan Accord; Topotecan Hospira chemotherapy, etoposide, carboplatin and vincristine or local ophthalmological treatment without IV chemotherapy, etoposide, carboplatin and vincristine chemotherapy, Carboplatin administered on Day 1, platinum-based chemotherapy, Thermotherapy (local treatment), Thermotherapy after carboplatin administered on Day 1, Cryotherapy (local treatment), Iodine-125 plaques (local treatment), Intravitreal Melphalan chemotherapy injections (local treatment)
Institut Curie, Fondation Rothschild Paris
Retinoblastoma
01/35
01/36
RETINO2011, NCT02866136: Conservative Treatments of Retinoblastoma

Active, not recruiting
2
133
Europe
VP16, carboplatin, etoposide, vepesid, chemotherapy, Melphalan, Alkeran, chemotherapy, VP16, carboplatin, vincristin, etoposide, vepesid, leurocristine, Oncovin, chemotherapy, Carboplatin + laser day 1 (chemothermotherapy), Carbo-laser, platinum-based chemotherapy, Laser (local treatment), Laser diode, cryoapplication (local treatment), I125 radioactive plaques (local treatment), intravitreal Melphalan (local treatment)
Institut Curie, Fondation Rothschild Paris
Retinoblastoma, Children, Retinal Neoplasm
01/23
09/35
NCT02870907 / 2009-016448-38: Adjuvant Treatment in Extensive Unilateral Retinoblastoma Primary Enucleated (RB SFCE 2009)

Recruiting
2
185
Europe
Observation, Low risk group, Etoposide, Intermediate risk sub group 1, Vincristine, Intermediate risk sub group 2, Orbital irradiation, High risk group, Carboplatin, Cyclophosphamide, Thiotepa, Cytapheresis, Peripheral bood stem cell transplantation
Institut Curie
Retinoblastoma
03/30
09/30
NEUROBLU 02, NCT03966651 / 2020-002996-36: A Clinical Study Evaluating the Safety of Peptide Receptor Radionuclide Therapy (PRRT) With 177Lu-DOTA0-Tyr3-Octreotate in Children With Refractory or Recurrent Neuroblastoma Expressing Somatostatin Receptors.

Recruiting
1
18
Europe
PRRT with 177Lu-DOTATATE
Institut Claudius Regaud, Advanced Accelerator Applications
Neuroblastoma
10/25
02/26
NCT03306251: National Cohort of Children Born to HIV-positive Mothers

Recruiting
N/A
5200
Europe, RoW
ANRS, Emerging Infectious Diseases
Mother to Child Transmission of HIV
03/23
03/23
SACHA, NCT04477681: Securing Access to Innovative Molecules in Oncology and Hematology for Children, Adolescents and Young Adults

Recruiting
N/A
1000
Europe
Data collection
Gustave Roussy, Cancer Campus, Grand Paris, Société Française des Cancers de l'Enfant (SFCE)
Pediatric Cancer
04/26
04/27
MICCHADO, NCT03496402: Biological Characterisation of High Risk CHildhood Cancer in Children, Adolescents and Young Adults

Active, not recruiting
N/A
600
Europe
Sampling on blood, bone marrow and cerebrospinal fluid
Institut Curie
Neuroblastoma, Rhabdomyosarcoma, Ewing Sarcoma Family of Tumors, Osteosarcoma, Leukemia, Central Nervous System Tumor
04/27
08/27
BIOPORTAL, NCT05192980: SIOPEN , an International Registry Linked to a Virtual Biobank for Patients with Peripheral Neuroblastic Tumours

Recruiting
N/A
600
Europe
No Intervention NA, Bio-sampling
Institut Curie
Neuroblastoma, Ganglioneuroblastoma, Ganglioneuroma
11/38
11/38
PTB, NCT05660499: Impact of the Development of Pediatric Palliative Care

Recruiting
N/A
40
Europe
University Hospital, Strasbourg, France
Primary Brain Tumor
12/23
12/23
Doz, François
SIOP-EP-II, NCT02265770 / 2013-002766-39: An International Clinical Program for the Diagnosis and Treatment of Children With Ependymoma

Recruiting
2/3
536
Europe, RoW
16 weeks of VEC + CDDP, Vincristine, Etoposide, Cyclophosphamide, Cisplatin, VEC + HD-MTX, Methotrexate, Chemotherapy + Valproate, Carboplatin, Valproate, Conformal radiotherapy, VEC, Chemotherapy, conformal radiotherapy +/- boost
Centre Leon Berard
Childhood Ependymoma
06/28
08/31
MS100070_0087, NCT05081180 / 2020-004397-22: Study of Avelumab in Combination With Lenvatinib for Children With Primary CNS Tumors

Active, not recruiting
1
17
Europe, Canada, RoW
Avelumab, Lenvatinib
EMD Serono Research & Development Institute, Inc., Merck KGaA, Darmstadt, Germany
Central Nervous System Tumors
12/25
12/25
SCOOP, NCT04544995 / 2020-002359-39: Dose Escalation and Cohort Expansion Study of Niraparib and Dostarlimab in Paediatric Participants With Solid Tumors

Recruiting
1
116
Europe, RoW
Niraparib (Tablet for oral suspension), Dostarlimab, Niraparib (Tablet)
GlaxoSmithKline
Neoplasms
10/29
05/30
CervIRM, NCT04174820: Child's Study of the Impact of PF Lesion on Motor Skills, Language, Cognitive Functioning and Social Cognition

Recruiting
N/A
145
Europe
Functional Magnetic Resonance Imaging (fMRI), Speech Therapy Tests, Neuropsychological Tests, Balance and Dexterity Tests
University Hospital, Angers, Assistance Publique - Hôpitaux de Paris, National Cancer Institute, France
Medulloblastoma, Childhood, Healthy Volunteers, Fossa Posterior Tumor, Low-grade Glioma
11/22
11/22
RISP-OTOTOX, NCT06957132: Analysis of Risk Factors for Hearing Loss in Survivors of Cancer Occurred During Childhood, Adolescence or Young Adulthood

Not yet recruiting
N/A
500
Europe
Audiogram, iAudiogram medical device
Gustave Roussy, Cancer Campus, Grand Paris
Ototoxicity, Drug-Induced, Ototoxicity, Radiation-Induced, Pediatric Cancer
04/26
04/26

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