| Gonzalez, Maria Jesus |
ASPIRE, NCT04118088: A Study of Darvadstrocel in Adults With Crohn's Disease and Complex Perianal Fistula |
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| Active, not recruiting | 4 | 50 | Europe, RoW | Darvadstrocel, Alofisel, Cx601 | Takeda, Takeda Development Center Americas, Inc. | Crohn's Disease, Complex Perianal Fistula | 03/26 | 03/26 | | |
NCT05357989: A Double-blind Study to Investigate Efficacy and Safety of Buntanetap Compared With Placebo in Participants With Early PD |
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| Completed | 3 | 523 | Europe, US | buntanetap/posiphen, Posiphen Tartrate, ANVS401, Placebo | Annovis Bio Inc., TFS Trial Form Support | Parkinson's Disease, Idiopathic | 12/23 | 12/23 | | |
| Recruiting | 2 | 70 | Europe | Ascorbic acid, Vitamin C, 0.9% Saline solution, Saline | Hospital Universitario Ramon y Cajal | Liver Transplantation, Postreperfusion Syndrome, Ascorbic Acid | 06/23 | 07/23 | | |
NCT04845178: Investigation of Safety and Efficacy of ABP-450 for Migraine Prevention in Adults |
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| Active, not recruiting | 2 | 797 | Canada, US, RoW | ABP-450, prabotulinumtoxinA, Placebo, 0.9% sodium chloride, saline | AEON Biopharma, Inc., PPD | Migraine | 06/24 | 09/24 | | |
NCT03340129: Anti-PD 1 Brain Collaboration + Radiotherapy Extension (ABC-X Study) |
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| Recruiting | 2 | 218 | Europe, RoW | Ipilimumab, Yervoy, Nivolumab, Opdivo, Stereotactic Radiotherapy, Salvage therapy | Melanoma Institute Australia, Bristol-Myers Squibb | Melanoma Stage Iv | 08/24 | 08/25 | | |
| Recruiting | 2 | 68 | Europe | Adagrasib | ETOP IBCSG Partners Foundation, Mirati Therapeutics Inc. | NSCLC Stage IV, KRAS P.G12C | 10/25 | 03/26 | | |
STX-001-01, NCT06249048: Study of IT STX-001 in Patients With Advanced Solid Tumors as Monotherapy or in Combination With Pembrolizumab |
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| Recruiting | 1/2 | 108 | US, RoW | STX-001, Keytruda®, Pembrolizumab | Strand Therapeutics Inc. | Advanced Solid Tumor | 05/27 | 11/28 | | |
NCT04232696: Neuspera's Implantable Sacral Nerve Stimulation System in Patients With Symptoms of Urinary Urgency Incontinence (UUI) |
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| Active, not recruiting | N/A | 242 | Europe, US | Neuspera Implantable Sacral Nerve Stimulation System | Neuspera Medical, Inc. | Urinary Urgency Incontinence | 07/24 | 12/26 | | |
| Recruiting | N/A | 639 | Europe | | University Hospital, Strasbourg, France | COVID-19 | 12/23 | 12/23 | | |
| Recruiting | N/A | 80 | Europe, US | Oxygen | Boston Children's Hospital, Massachusetts General Hospital, Massachusetts Institute of Technology, National Institute for Biomedical Imaging and Bioengineering (NIBIB), Madrid-MIT M+Visión Consortium | Intrauterine Growth Restriction | 09/25 | 09/26 | | |
| Completed | N/A | 5694 | Europe | | University Hospital, Strasbourg, France | COVID-19 | 04/22 | 06/22 | | |
| Long, Georgina |
| Active, not recruiting | 3 | 423 | Europe, US, RoW | Neoadjuvant ipilimumab + nivolumab, Yervoy + Opdivo, Adjuvant nivolumab, Opdivo | The Netherlands Cancer Institute, Bristol-Myers Squibb | Malignant Melanoma Stage III | 01/24 | 12/28 | | |
ACTRN12613000737730: An open label, single centre, phase II pilot study of neoadjuvant dabrafenib + trametinib in patients with resectable AJCC Stage IIIB-C BRAF V600 mutation positive melanoma |
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| Active, not recruiting | 2 | 35 | | | Melanoma Institute Australia, GlaxoSmithKline Australia | Melanoma | | | | |
ACTRN12614001315606: A phase II study of nivolumab and nivolumab combined with ipilimumab in patients with melanoma brain metastases (ABC - Anti-PD1 Brain Collaboration Study) |
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| Active, not recruiting | 2 | 75 | | | Melanoma Institute Australia , Melanoma Institute Australia | Melanoma Brain Metastases, Melanoma | | | | |
Neo Combi, NCT01972347: Neoadjuvant Dabrafenib + Trametinib for AJCC Stage IIIB-C BRAF V600 Mutation Positive Melanoma |
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| Active, not recruiting | 2 | 35 | RoW | Dabrafenib, GSK2118436, Trametinib, GSK1120212 | Melanoma Institute Australia | Melanoma | 05/17 | 05/24 | | |
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| Active, not recruiting | 2 | 76 | RoW | Nivolumab, Opdivo, BMS-936558, Ipilimumab, Yervoy, BMS-734016 | Melanoma Institute Australia, Melanoma and Skin Cancer Trials Limited, Bristol-Myers Squibb | Melanoma, Brain Metastases | 09/17 | 12/28 | | |
NeoTrio, NCT02858921: Neoadjuvant Dabrafenib, Trametinib and/or Pembrolizumab in BRAF Mutant Resectable Stage III Melanoma |
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| Active, not recruiting | 2 | 60 | RoW | Dabrafenib, Tafinlar, Trametinib, Mekinist, Pembrolizumab, Keytruda | Melanoma Institute Australia, Merck Sharp & Dohme LLC, Novartis | Melanoma | 01/22 | 11/24 | | |
Neo PeLe, NCT04207086: A Phase II Study of Neoadjuvant Pembrolizumab & Lenvatinib for Resectable Stage III Melanoma |
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| Active, not recruiting | 2 | 21 | RoW | Pembrolizumab, Keytruda, Lenvatinib, Lenvima | Melanoma Institute Australia, Merck Sharp & Dohme LLC | Melanoma Stage III | 01/23 | 01/33 | | |
| Recruiting | 2 | 20 | RoW | Nivolumab 240 mg / Relatlimab 80 mg in a fixed dose combination, Opdualag | Melanoma Institute Australia, Bristol-Myers Squibb | Merkel Cell Carcinoma | 04/26 | 04/34 | | |
| Terminated | 2 | 205 | Europe, US, RoW | ladiratuzumab vedotin, SGN-LIV1A, pembrolizumab, Keytruda | Seagen Inc., Merck Sharp & Dohme LLC | Small Cell Lung Cancer, Non-small Cell Lung Cancer, Squamous, Non-small Cell Lung Cancer, Non-squamous, Head and Neck Squamous Cell Carcinoma, Esophageal Squamous Cell Carcinoma, Gastric Adenocarcinoma, Gastroesophageal Junction Adenocarcinoma, Prostate Cancer, Melanoma | 11/23 | 11/23 | | |
NCT03340129: Anti-PD 1 Brain Collaboration + Radiotherapy Extension (ABC-X Study) |
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| Recruiting | 2 | 218 | Europe, RoW | Ipilimumab, Yervoy, Nivolumab, Opdivo, Stereotactic Radiotherapy, Salvage therapy | Melanoma Institute Australia, Bristol-Myers Squibb | Melanoma Stage Iv | 08/24 | 08/25 | | |
Neo ReNi II, NCT05418972: A Phase 2 Clinical Trial of Neoadjuvant Relatlimab and Nivolumab in High Risk, Clinical Stage II Cutaneous Melanoma |
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| Recruiting | 2 | 20 | RoW | Relatlimab and nivolumab fixed dose combination (FDC), Opdualag | Melanoma Institute Australia, Bristol-Myers Squibb | Stage II Melanoma | 12/24 | 12/34 | | |
KEYNOTE-D36, NCT05309421: A Single Arm Trial Evaluating the Efficacy and Safety of EVX-01 in Combination With Pembrolizumab in Adults With Unresectable or Metastatic Melanoma |
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| Recruiting | 2 | 90 | RoW | EVX-01, Pembrolizumab 25 MG/ML, Keytruda | Evaxion Biotech A/S, Merck Sharp & Dohme LLC | Melanoma Stage III, Melanoma Stage IV | 06/25 | 07/25 | | |
KEYNOTE-E40, NCT05280314: Phase II Trial of Neoadjuvant and Adjuvant IO102-IO103 and Pembrolizumab KEYTRUDA® in Patients With Resectable Tumors |
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| Recruiting | 2 | 60 | Europe, US, RoW | IO102-IO103, Pembrolizumab KEYTRUDA® | IO Biotech, Theradex, Almac, Merck Sharp & Dohme LLC | Melanoma, Squamous Cell Carcinoma of Head and Neck | 04/25 | 01/27 | | |
I-MAT, NCT04291885: Immunotherapy Adjuvant Trial in Patients With Stage I-III Merkel Cell Carcinoma |
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| Recruiting | 2 | 132 | RoW | Avelumab, anti-PD-L1, Bavencio, Placebo | Melanoma and Skin Cancer Trials Limited | Merkel Cell Carcinoma, Merkel Cell Carcinoma, Stage I, Merkel Cell Carcinoma, Stage II, Merkel Cell Carcinoma, Stage III, Neuroendocrine Tumors, Carcinoma Neuroendocrine Skin | 04/27 | 04/28 | | |
| Withdrawn | 2 | 44 | RoW | Pembrolizumab, Keytruda, Lenvatinib, Lenvima | Melanoma Institute Australia, Merck Sharp & Dohme LLC | Mucosal Melanoma | 05/26 | 05/36 | | |
| Recruiting | 2 | 1000 | RoW | Standard therapy or clinical trial, Immunotherapy, Biological agent, Matched targeted therapy, ALK - Ceritinib, BRAF fusion - Trametinib, CCND1 - Ribociclib + Trametinib, CDK4/6 - Ribociclib + Trametinib, CDKN2A - Ribociclib + Trametinib, GNA11 - Trametinib, GNAQ - Trametinib, HRAS - Trametinib, KIT - Pazopanib, KRAS - Trametinib, MAP2K1 - Trametinib, NF1 - Trametinib, MET - Ceritinib, RAS - Ribociclib + Trametinib, ROS1 - Ceritinib, Trametinib and / or supportive care, Trametinib, Supportive care, CDK4/6 and MEK inhibitor, Ribociclib + Trametinib, Compassionate Access Targeted Therapy, Off label use of a matched targeted therapy currently unavailable to the study | Melanoma Institute Australia, Novartis | Melanoma | 07/27 | 12/28 | | |
NCT04834973: A Trial of Tigilanol Tiglate in Combination With Pembrolizumab in Stage IIIB to IV M1c-melanoma |
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| Terminated | 1/2 | 3 | RoW | tigilanol tiglate, EBC-46, pembrolizumab, Keytruda | QBiotics Group Limited, Merck Sharp & Dohme LLC | Melanoma | 07/22 | 07/22 | | |
| Guitera, Pascale |
ACTRN12615000266561: A randomised controlled multicentre trial of imiquimod versus radiotherapy for lentigo maligna (LM) when staged surgical excision with 5mm margins is not possible, is refused, or fails. |
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| Active, not recruiting | 3 | 266 | | | Melanoma and Skin Cancer (MASC) Trials, Cancer Australia | Lentigo maligna (LM) | | | | |
| Completed | 3 | 126 | RoW | Imiquimod, Aldara, Radiotherapy | Melanoma and Skin Cancer Trials Limited, Melanoma Institute Australia | Lentigo Maligna | 12/21 | 03/23 | | |
SONIB, NCT03534947: A Study to Evaluate Neoadjuvant Sonidegib Followed by Surgery or Imiquimod in the Management of Basal Cell Carcinoma |
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| Recruiting | 2 | 20 | RoW | Sonidegib, LDE225, Odomzo, Imiquimod, Aldara, Surgery, Excision of remnant invasive basal cell carcinoma, Best supportive care | Melanoma Institute Australia | Basal Cell Carcinoma, Basal Cell Carcinoma of Skin, Site Unspecified, Skin Cancer, Invasive Carcinoma | 06/24 | 06/24 | | |
IMAGE, NCT04385732: Melanoma Surveillance Photography (MSP) to Improve Early Detection of Melanoma in Ultra-high and High Risk Patients |
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| Active, not recruiting | N/A | 670 | RoW | 2D or 3D Melanoma Surveillance Photography | Melanoma and Skin Cancer Trials Limited, Monash University, University of Sydney, The University of Queensland | Melanoma, Skin Cancer, Anxiety and Fear | 02/25 | 02/25 | | |
| Meniawy, Tarek |
ACTRN12618000109202: A Phase II Study of Durvalumab and Tremelimumab in combination with Neoadjuvant Carboplatin and Paclitaxel in newly diagnosed women with advanced high grade Serous Ovarian, Fallopian Tube and Peritoneal Cancers “iPRIME”. |
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| Active, not recruiting | 2 | 75 | | | Australia New Zealand Gynaecological Oncology Group (ANZGOG), Australia New Zealand Gynaecological Oncology Group (ANZGOG) | Ovarian cancer, Fallopian tube cancer, Peritoneal cancer | | | | |
| Active, not recruiting | 2 | 76 | Canada, US, RoW | ZN-c3, azenosertib, KP-2638 | K-Group, Beta, Inc., a wholly owned subsidiary of Zentalis Pharmaceuticals, Inc | Uterine Serous Carcinoma | 11/24 | 05/25 | | |
DENALI, NCT05128825: A Study of ZN-c3 in Subjects With High-Grade Serous Ovarian, Fallopian Tube or Primary Peritoneal Cancer |
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| Active, not recruiting | 2 | 102 | Europe, US, RoW | ZN-c3, azenosertib | K-Group, Beta, Inc., a wholly owned subsidiary of Zentalis Pharmaceuticals, Inc | High-Grade Serous Ovarian, Fallopian Tube or Primary Peritoneal Cancer | 04/25 | 10/25 | | |
KEYNOTE-D36, NCT05309421: A Single Arm Trial Evaluating the Efficacy and Safety of EVX-01 in Combination With Pembrolizumab in Adults With Unresectable or Metastatic Melanoma |
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| Recruiting | 2 | 90 | RoW | EVX-01, Pembrolizumab 25 MG/ML, Keytruda | Evaxion Biotech A/S, Merck Sharp & Dohme LLC | Melanoma Stage III, Melanoma Stage IV | 06/25 | 07/25 | | |
Keynote-942, NCT03897881: An Efficacy Study of Adjuvant Treatment With the Personalized Cancer Vaccine mRNA-4157 and Pembrolizumab in Participants With High-Risk Melanoma (KEYNOTE-942) |
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| Recruiting | 2 | 267 | US, RoW | mRNA-4157, Pembrolizumab | ModernaTX, Inc., Merck Sharp & Dohme LLC | Melanoma | 09/29 | 09/29 | | |
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| Recruiting | 1/2 | 38 | RoW | Avelumab, Bavencio, Anti-PD-L1, External Beam Radiation Therapy (EBRT), Radiotherapy, Lutetium-177 (177Lu)-DOTATATE, Peptide Receptor Radionuclide Therapy (PRRT), Lutathera | Melanoma and Skin Cancer Trials Limited | Metastatic Merkel Cell Carcinoma | 07/25 | 07/27 | | |
NCT04814875: A Study to Evaluate the Combination of ATX-101 and Platinum-based Chemotherapy |
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| Terminated | 1/2 | 16 | RoW | ATX-101 + Carboplatin + Pegylated liposomal doxorubicin (ACD) | THERAPIM PTY LTD, Novotech (Australia) Pty Limited | Ovarian Cancer, Fallopian Tube Cancer, Primary Peritoneal Carcinoma, High Grade Serious or Endometrioid Carcinoma of the Ovary, Fallopian Tube, or Primary Peritoneal Cancer | 11/23 | 11/23 | | |
| Active, not recruiting | 1 | 500 | Europe, Japan, US, RoW | LY3484356, Imlunestrant, Abemaciclib, LY2835219, Everolimus, Alpelisib, Trastuzumab, Aromatase Inhibitor (AI), Pertuzumab | Eli Lilly and Company | Breast Cancer, Advanced Breast Cancer, Metastatic Breast Cancer, Endometrial Cancer | 06/20 | 12/27 | | |
| Active, not recruiting | 1 | 449 | US, RoW | Ociperlimab, Tislelizumab, Pemetrexed, Paclitaxel, Nab paclitaxel, Carboplatin, Cisplatin, Etoposide, 5fluorouracil, Oxaliplatin, Capecitabine | BeiGene | Locally Advanced and Metastatic Solid Tumors | 08/24 | 08/24 | | |
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| Guitera, Pascal |
SONIB, NCT03534947: A Study to Evaluate Neoadjuvant Sonidegib Followed by Surgery or Imiquimod in the Management of Basal Cell Carcinoma |
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| Recruiting | 2 | 20 | RoW | Sonidegib, LDE225, Odomzo, Imiquimod, Aldara, Surgery, Excision of remnant invasive basal cell carcinoma, Best supportive care | Melanoma Institute Australia | Basal Cell Carcinoma, Basal Cell Carcinoma of Skin, Site Unspecified, Skin Cancer, Invasive Carcinoma | 06/24 | 06/24 | | |
